Page last updated: 2024-10-20

propylene glycol and Allergic Contact Dermatitis

propylene glycol has been researched along with Allergic Contact Dermatitis in 42 studies

Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.

Research Excerpts

ExcerptRelevanceReference
"A woman developed a pruritic exacerbation of her methotrexate-dependent psoriasis after applying topical calcipotriene ointment."7.69Allergic contact dermatitis to propylene glycol in calcipotriene ointment. ( Fisher, DA, 1997)
"Propylene glycol (PG) has widespread use in pharmaceuticals, cosmetics, fragrances and personal care products."7.01Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum. ( Kimber, I; Pemberton, MA, 2023)
"A 63-year-old man with hepatocellular carcinoma consequent to chronic viral hepatitis C presented with severe dermatitis on the lower right side of the back after transcatheter arterial chemoembolization (TACE) via the 10th intercostal artery, because his hepatic artery had already collapsed due to repeated usage for TACE."5.33A case of allergic contact dermatitis from propylene glycol in an ultrasonic gel, sensitized at a leakage skin injury due to transcatheter arterial chemoembolization for hepatocellular carcinoma. ( Fujii, S; Honda, T; Horiguchi, Y; Matsushima, S; Osaki, Y, 2005)
"The low concentration of propylene glycol (PG) in pimecrolimus cream makes it unlikely that the cream will induce a PG-related irritant or allergic contact dermatitis."5.12Skin reactions to pimecrolimus cream 1% in patients allergic to propylene glycol: a double-blind randomized study. ( Douglas, JL; Fowler, JF; Fowler, L; Parneix-Spake, A; Thorn, D, 2007)
"A woman developed a pruritic exacerbation of her methotrexate-dependent psoriasis after applying topical calcipotriene ointment."3.69Allergic contact dermatitis to propylene glycol in calcipotriene ointment. ( Fisher, DA, 1997)
"Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method."3.65Skin reactions to propylene glycol. ( Hannuksela, M; Pirilä, V; Salo, OP, 1975)
"Propylene glycol (PG) has widespread use in pharmaceuticals, cosmetics, fragrances and personal care products."3.01Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum. ( Kimber, I; Pemberton, MA, 2023)
"A 63-year-old man with hepatocellular carcinoma consequent to chronic viral hepatitis C presented with severe dermatitis on the lower right side of the back after transcatheter arterial chemoembolization (TACE) via the 10th intercostal artery, because his hepatic artery had already collapsed due to repeated usage for TACE."1.33A case of allergic contact dermatitis from propylene glycol in an ultrasonic gel, sensitized at a leakage skin injury due to transcatheter arterial chemoembolization for hepatocellular carcinoma. ( Fujii, S; Honda, T; Horiguchi, Y; Matsushima, S; Osaki, Y, 2005)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.38)18.7374
1990's8 (19.05)18.2507
2000's14 (33.33)29.6817
2010's11 (26.19)24.3611
2020's8 (19.05)2.80

Authors

AuthorsStudies
Silverberg, JI1
Hou, A1
Warshaw, EM2
Maibach, HI1
Belsito, DV1
DeKoven, JG1
Zug, KA1
Taylor, JS1
Sasseville, D1
Fransway, AF1
DeLeo, VA1
Pratt, MD1
Reeder, MJ1
Atwater, AR1
Fowler, JF2
Zirwas, MJ2
Marks, JG1
Peterson, MY1
Han, J1
Pemberton, MA1
Kimber, I1
Patel, K1
Palmer, A1
Nixon, R1
Lamouroux, C1
Bertolotti-Potachin, L1
Charbotel, B1
Nosbaum, A1
Nicolas, JF1
Luna-Bastante, L1
Gatica-Ortega, ME1
Pastor-Nieto, MA1
Vergara-de-la-Campa, L1
Gómez-Dorado, BA1
Alonso-Naranjo, L1
Pérez-Hortet, C1
Lee, EB1
Lobl, M1
Ford, A1
DeLeo, V1
Adler, BL1
Wysong, A1
Barakat, L1
Dereure, O1
Raison-Peyron, N1
Hernández, N1
Hernández, Z1
Liuti, F1
Borrego, L1
Özkaya, E1
Kılıç, S1
Brar, KK1
Leung, DYM1
Milam, EC2
Cohen, DE2
Franken, L1
de Groot, A1
Laheij-de Boer, AM1
Aljasser, MI1
Al-Omair, IA1
Watzek, N1
Berger, F1
Kolle, SN1
Kaufmann, T1
Becker, M1
van Ravenzwaay, B1
Motolese, A1
Capriata, S1
Simonelli, M1
Nijhawan, RI1
Molenda, M1
Jacob, SE1
Rühlemann, D1
Kügler, K1
Mydlach, B1
Frosch, PJ1
Foti, C1
Bonamonte, D1
Cassano, N1
Conserva, A1
Vena, GA1
Al Jasser, M1
Mebuke, N1
de Gannes, GC1
Lamb, SR1
Ardley, HC1
Wilkinson, SM1
Eguino, P1
Sánchez, A1
Agesta, N1
Lasa, O1
Ratón, JA1
Díaz-Pérez, JL1
Farrar, CW1
Bell, HK1
King, CM1
Panda, S1
Malakar, S1
Connolly, M1
Buckley, DA1
Horiguchi, Y1
Honda, T1
Fujii, S1
Matsushima, S1
Osaki, Y1
Lessmann, H1
Schnuch, A1
Geier, J1
Uter, W2
Kuznetsov, AV1
Erlenkeuser-Uebelhoer, I1
Thomas, P1
Fowler, L1
Douglas, JL1
Thorn, D1
Parneix-Spake, A1
Ueno, M1
Adachi, A1
Horikawa, T1
Inoue, N1
Mori, A1
Sasaki, K1
Kerre, S1
Corazza, M1
Virgili, A1
Mantovani, L1
La Malfa, W1
Kim, YJ1
Kim, JH1
el Sayed, F1
Bayle-Lebey, P1
Marguery, MC1
Bazex, J1
Schwanitz, HJ1
Fisher, AA1
Fisher, DA1
Lahti, A1
Noponen, SL1
Gonzalo, MA1
de Argila, D1
García, JM1
Alvarado, MI1
Scheman, AJ1
West, DP1
Hordinksy, MK1
Osburn, AH1
West, LE1
Hannuksela, M1
Pirilä, V1
Salo, OP1

Reviews

6 reviews available for propylene glycol and Allergic Contact Dermatitis

ArticleYear
Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum.
    Regulatory toxicology and pharmacology : RTP, 2023, Volume: 138

    Topics: Allergens; Animals; Cosmetics; Dermatitis, Allergic Contact; Guinea Pigs; Humans; Mice; Patch Tests;

2023
What Is New in Occupational Allergic Contact Dermatitis in the Year of the COVID Pandemic?
    Current allergy and asthma reports, 2021, 03-29, Volume: 21, Issue:4

    Topics: Acrylates; Acyclic Monoterpenes; Allergens; Allergy and Immunology; Camphanes; COVID-19; Dermatitis,

2021
Eczema complicated by allergic contact dermatitis to topical medications and excipients.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2018, Volume: 120, Issue:6

    Topics: Administration, Inhalation; Administration, Intranasal; Adrenal Cortex Hormones; Adult; Anti-Inflamm

2018
Contact Dermatitis: Emerging Trends.
    Dermatologic clinics, 2019, Volume: 37, Issue:1

    Topics: Acrylates; Allergens; Dermatitis, Allergic Contact; Humans; Metals; Perfume; Phenylenediamines; Pres

2019
Systemic contact dermatitis.
    Dermatologic clinics, 2009, Volume: 27, Issue:3

    Topics: Allergens; Asteraceae; Balsams; Dermatitis, Allergic Contact; Dermatology; Drug-Related Side Effects

2009
Skin-sensitizing and irritant properties of propylene glycol.
    Contact dermatitis, 2005, Volume: 53, Issue:5

    Topics: Adult; Animals; Case-Control Studies; Dermatitis, Allergic Contact; Dermatitis, Irritant; Dermatitis

2005

Trials

1 trial available for propylene glycol and Allergic Contact Dermatitis

ArticleYear
Skin reactions to pimecrolimus cream 1% in patients allergic to propylene glycol: a double-blind randomized study.
    Dermatitis : contact, atopic, occupational, drug, 2007, Volume: 18, Issue:3

    Topics: Administration, Cutaneous; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Al

2007

Other Studies

35 other studies available for propylene glycol and Allergic Contact Dermatitis

ArticleYear
Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001-2016.
    Archives of dermatological research, 2022, Volume: 314, Issue:9

    Topics: Allergens; Bacitracin; Benzalkonium Compounds; Cosmetics; Dermatitis, Allergic Contact; Eczema; Form

2022
Allergic contact dermatitis from dipropylene glycol in hydrocortisone lotion.
    Contact dermatitis, 2022, Volume: 87, Issue:1

    Topics: Dermatitis, Allergic Contact; Glycols; Humans; Hydrocortisone; Patch Tests; Propylene Glycol

2022
Allergic contact dermatitis from propylene glycol: A case series from Australia.
    Contact dermatitis, 2023, Volume: 89, Issue:2

    Topics: Allergens; Dermatitis, Allergic Contact; Dermatologic Agents; Glucocorticoids; Humans; Patch Tests;

2023
Allergic contact dermatitis to diclofenac gel due to propylene glycol sensitization: usefulness of repeated open application tests to determine safer alternatives.
    European journal of dermatology : EJD, 2023, 02-01, Volume: 33, Issue:1

    Topics: Dermatitis, Allergic Contact; Diclofenac; Humans; Patch Tests; Propylene Glycol

2023
Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics.
    Contact dermatitis, 2020, Volume: 82, Issue:5

    Topics: Adult; Dermatitis, Allergic Contact; Eyelid Diseases; Female; Humans; Patch Tests; Phenols; Plant Ex

2020
A police case: Finding propylene glycol guilty as culprit allergen.
    Contact dermatitis, 2021, Volume: 85, Issue:4

    Topics: Dermatitis, Allergic Contact; Female; Humans; Middle Aged; Patch Tests; Pharmaceutical Vehicles; Pro

2021
Intolerance to cosmetics as key to the diagnosis in a patient with allergic contact dermatitis caused by propylene glycol contained in a topical medication.
    Contact dermatitis, 2017, Volume: 76, Issue:4

    Topics: Acyclovir; Administration, Cutaneous; Adult; Cosmetics; Dermatitis, Allergic Contact; Female; Humans

2017
Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey.
    Contact dermatitis, 2018, Volume: 78, Issue:3

    Topics: Adult; Aged; Anti-Infective Agents; Cross-Sectional Studies; Dermatitis, Allergic Contact; Female; H

2018
Clinically relevant contact allergens in the modern era.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2019, Volume: 123, Issue:6

    Topics: Acrylates; Allergens; Dermatitis, Allergic Contact; Food Preservatives; Haptens; Humans; Odorants; P

2019
Allergic contact dermatitis caused by menthoxypropanediol in a lip cosmetic.
    Contact dermatitis, 2013, Volume: 69, Issue:6

    Topics: Cosmetics; Dermatitis, Allergic Contact; Female; Humans; Lip; Middle Aged; Propylene Glycol

2013
Propylene glycol allergic contact dermatitis. A quick reference guide for propylene glycol-free topical corticosteroids in Saudi Arabia.
    Saudi medical journal, 2013, Volume: 34, Issue:12

    Topics: Administration, Topical; Adrenal Cortex Hormones; Dermatitis, Allergic Contact; Humans; Pharmaceutic

2013
Assessment of skin sensitization under REACH: A case report on vehicle choice in the LLNA and its crucial role preventing false positive results.
    Regulatory toxicology and pharmacology : RTP, 2017, Volume: 85

    Topics: Acetone; Allergens; Animals; Cyclohexylamines; Dermatitis, Allergic Contact; Excipients; Female; Hap

2017
Contact sensitivity to 'advanced' wound dressings in 116 patients with leg ulcers.
    Contact dermatitis, 2009, Volume: 60, Issue:2

    Topics: Administration, Topical; Allergens; Dermatitis, Allergic Contact; Female; Humans; Hydrogel, Polyethy

2009
Contact dermatitis to self-adhesive ECG electrodes.
    Contact dermatitis, 2010, Volume: 62, Issue:5

    Topics: Adhesives; Dermatitis, Allergic Contact; Electrocardiography; Electrodes; Female; Humans; Long QT Sy

2010
Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream.
    The Australasian journal of dermatology, 2010, Volume: 51, Issue:2

    Topics: Administration, Topical; Antioxidants; Dermatitis, Allergic Contact; Dermatitis, Seborrheic; Drug Co

2010
Propylene glycol: an often unrecognized cause of allergic contact dermatitis in patients using topical corticosteroids.
    Skin therapy letter, 2011, Volume: 16, Issue:5

    Topics: Administration, Cutaneous; Dermatitis, Allergic Contact; Drug Eruptions; Excipients; Female; Glucoco

2011
Contact allergy to propylene glycol in brassiere padding inserts.
    Contact dermatitis, 2003, Volume: 48, Issue:4

    Topics: Adult; Allergens; Breast; Clothing; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; G

2003
Allergic contact dermatitis due to propylene glycol and parabens in an ultrasonic gel.
    Contact dermatitis, 2003, Volume: 48, Issue:5

    Topics: Administration, Cutaneous; Dermatitis, Allergic Contact; Diagnosis, Differential; Gels; Humans; Leg;

2003
Allergic contact dermatitis from propylene glycol in Efudix cream.
    Contact dermatitis, 2003, Volume: 48, Issue:6

    Topics: Administration, Topical; Aged; Aged, 80 and over; Dermatitis, Allergic Contact; Dermatologic Agents;

2003
Lichen nitidus-like allergic contact dermatitis - a clinicopathological study.
    Contact dermatitis, 2003, Volume: 49, Issue:1

    Topics: Case-Control Studies; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Hand Dermatose

2003
Contact dermatitis from propylene glycol in ECG electrodes, complicated by medicament allergy.
    Contact dermatitis, 2004, Volume: 50, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Dermatitis, Allergic Contact; Electrocardiography; Electrodes; Humans;

2004
A case of allergic contact dermatitis from propylene glycol in an ultrasonic gel, sensitized at a leakage skin injury due to transcatheter arterial chemoembolization for hepatocellular carcinoma.
    International journal of dermatology, 2005, Volume: 44, Issue:8

    Topics: Carcinoma, Hepatocellular; Catheterization; Chemoembolization, Therapeutic; Dermatitis, Allergic Con

2005
Contact allergy to propylene glycol and dodecyl gallate mimicking seborrheic dermatitis.
    Contact dermatitis, 2006, Volume: 55, Issue:5

    Topics: Adult; Cosmetics; Dermatitis, Allergic Contact; Dermatitis, Seborrheic; Diagnosis, Differential; Gal

2006
Allergic contact dermatitis caused by poly(adipic acid-co-1,2-propylene glycol) and di-(n-octyl) tin-bis(2-ethylhexylmaleate) in vinyl chloride gloves.
    Contact dermatitis, 2007, Volume: 57, Issue:5

    Topics: Adipates; Adult; Allergens; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; Gloves, P

2007
Allergic contact dermatitis to pentylene glycol in a cosmetic cream.
    Contact dermatitis, 2008, Volume: 58, Issue:2

    Topics: Cosmetics; Cross Reactions; Dermatitis, Allergic Contact; Female; Glycols; Humans; Middle Aged; Patc

2008
Propylene glycol allergy from acyclovir cream with cross-reactivity to hydroxypropyl cellulose in a transdermal estradiol system?
    Contact dermatitis, 1993, Volume: 29, Issue:5

    Topics: Acyclovir; Administration, Cutaneous; Cellulose; Cryoprotective Agents; Dermatitis, Allergic Contact

1993
Allergic contact dermatitis from propylene glycol in Zovirax cream.
    Contact dermatitis, 1994, Volume: 30, Issue:2

    Topics: Acyclovir; Administration, Cutaneous; Dermatitis, Allergic Contact; Herpes Zoster; Humans; Male; Mid

1994
Contact dermatitis from propylene glycol in Rifocine.
    Contact dermatitis, 1995, Volume: 33, Issue:2

    Topics: Administration, Topical; Dermatitis, Allergic Contact; Drug Hypersensitivity; Humans; Male; Middle A

1995
Contact dermatitis from propylene glycol in ECG electrode gel.
    Contact dermatitis, 1996, Volume: 34, Issue:3

    Topics: Dermatitis, Allergic Contact; Electrocardiography, Ambulatory; Electrodes; Erythema; Gels; Humans; M

1996
Systemic contact dermatitis caused by ingestion of certain foods in propylene glycol-sensitive patients.
    American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1996, Volume: 7, Issue:4

    Topics: Antioxidants; Dermatitis, Allergic Contact; Female; Food; Humans; Middle Aged; Patch Tests; Propylen

1996
Allergic contact dermatitis to propylene glycol in calcipotriene ointment.
    Cutis, 1997, Volume: 60, Issue:1

    Topics: Aged; Antioxidants; Calcitriol; Dermatitis, Allergic Contact; Dermatologic Agents; Female; Humans; M

1997
Propylene glycol in an isopropanol vehicle enhances immediate irritant reactions to benzoic acid.
    Contact dermatitis, 1998, Volume: 39, Issue:3

    Topics: 2-Propanol; Adult; Benzoic Acid; Dermatitis, Allergic Contact; Female; Humans; Irritants; Laser-Dopp

1998
Allergic contact dermatitis to propylene glycol.
    Allergy, 1999, Volume: 54, Issue:1

    Topics: Aged; Dermatitis, Allergic Contact; Drug Hypersensitivity; Humans; Male; Patch Tests; Propylene Glyc

1999
Alternative formulation for patients with contact reactions to topical 2% and 5% minoxidil vehicle ingredients.
    Contact dermatitis, 2000, Volume: 42, Issue:4

    Topics: Administration, Topical; Alopecia; Chemistry, Pharmaceutical; Dermatitis, Allergic Contact; Dose-Res

2000
Skin reactions to propylene glycol.
    Contact dermatitis, 1975, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Allergic Contact; Dermatitis, Contact; Drug Eru

1975