propylene glycol has been researched along with Acute Liver Injury, Drug-Induced in 3 studies
Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ganetsky, M | 2 |
| Berg, AH | 1 |
| Solano, JJ | 1 |
| Salhanick, S | 1 |
| Böhlke, M | 1 |
| Pereira, L | 1 |
| Williams, D | 1 |
| LeDuc, B | 1 |
| Guatam, S | 1 |
| Salhanick, SD | 1 |
| Zhao, YZ | 1 |
| Zhang, L | 1 |
| Gupta, PK | 1 |
| Tian, FR | 1 |
| Mao, KL | 1 |
| Qiu, KY | 1 |
| Yang, W | 1 |
| Lv, CZ | 1 |
| Lu, CT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect on Acetaminophen Metabolism by Liquid Formulations: Do Excipients in Liquid Formulation Prevent Production of Toxic Metabolites?[NCT01246713] | 15 participants (Actual) | Interventional | 2010-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Area-under-curve from time zero to 8 hours for APAP-cysteinate metabolite. Serum was collected just prior to and at hours 1, 2, 4, 6, and 8 after administration of the APAP dose. (NCT01246713)
Timeframe: 8 hours
| Intervention | mcg.hr/ml (Mean) |
|---|---|
| Acetaminophen Solid Formulation | 2.411 |
| Acetaminophen Liquid Formulation | 2.009 |
2 trials available for propylene glycol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Inhibition of CYP2E1 With Propylene Glycol Does Not Protect Against Hepatocellular Injury in Human Acetaminophen Daily-Dosing Model.
Topics: Acetaminophen; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; C | 2019 |
Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Chemical and Drug I | 2013 |
1 other study available for propylene glycol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease.
Topics: Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Delivery Systems; Ethanol; H | 2016 |