propylene glycol has been researched along with Acidosis in 28 studies
Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis." | 8.12 | Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022) |
| "Hyperosmolar increased-anion-gap metabolic acidosis without hyperglycemia has been reported after infusions of etomidate and other medications containing propylene glycol." | 7.74 | Hyperosmolar, increased-anion-gap metabolic acidosis and hyperglycemia after etomidate infusion. ( Audu, P; Ganesh, A, 2008) |
| " He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap metabolic acidosis, and acute kidney injury on his eighth day of hospitalization." | 7.74 | Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. ( Graeber, C; Sullivan, A; Yusufzai, I; Zar, T, 2007) |
| "A case of propylene glycol poisoning is described in a 39 year old woman which resulted in her admission to hospital in status epilepticus." | 7.67 | Cerebral depression due to propylene glycol in a patient with chronic epilepsy--the value of the plasma osmolal gap in diagnosis. ( Flanagan, RJ; Francis, DA; Lascelles, PT; Little, P; Lolin, Y, 1988) |
| " Serum propylene glycol concentrations were drawn at 48 hrs into the high-dose lorazepam infusion, and the presence of propylene glycol accumulation, as evidenced by a high anion gap (> or =15 mmol/L) metabolic acidosis with elevated osmol gap (> or =10 mOsm/L), was assessed at that time." | 5.11 | Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults. ( Arroliga, AC; Gonzales, JP; McCarthy, K; Shehab, N, 2004) |
| "I searched MEDLINE for articles published between 1969 and 2014 using the terms: toxic alcohols, serum osmolality, serum osmol gap, serum anion gap, metabolic acidosis, methanol, ethylene glycol, diethylene glycol, propylene glycol, and fomepizole." | 4.91 | Diagnosis of toxic alcohols: limitations of present methods. ( Kraut, JA, 2015) |
| "The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis." | 4.12 | Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022) |
| "While some case reports indicate that high doses of propylene glycol (PG) may result in metabolic acidosis, there has been no large-scale study that evaluated the risk of metabolic acidosis in patients receiving PG-containing benzodiazepines for acute alcohol withdrawal." | 3.88 | Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model. ( Bodreau, C; Elbarbry, F; Farthing, K; Jahn, A, 2018) |
| "Hyperosmolar increased-anion-gap metabolic acidosis without hyperglycemia has been reported after infusions of etomidate and other medications containing propylene glycol." | 3.74 | Hyperosmolar, increased-anion-gap metabolic acidosis and hyperglycemia after etomidate infusion. ( Audu, P; Ganesh, A, 2008) |
| " He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap metabolic acidosis, and acute kidney injury on his eighth day of hospitalization." | 3.74 | Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. ( Graeber, C; Sullivan, A; Yusufzai, I; Zar, T, 2007) |
| "5 degrees C, lethargy, polypnea; propylene glycol intoxication through disposable cleansing towels chewing was ascertained by anamnesis and blood urine analyses which revealed metabolic acidosis and serum propylene glycol peak." | 3.71 | [Home environment and acute propylene glycol intoxication in a two-year old. An unusual case report]. ( Amiour, M; Bocquet, G; Eckart, P; el-Hachem, C; Galliot-Guilley, M; Garnier, R; Guillot, M; Haguenoer, JM, 2002) |
| "A case of propylene glycol poisoning is described in a 39 year old woman which resulted in her admission to hospital in status epilepticus." | 3.67 | Cerebral depression due to propylene glycol in a patient with chronic epilepsy--the value of the plasma osmolal gap in diagnosis. ( Flanagan, RJ; Francis, DA; Lascelles, PT; Little, P; Lolin, Y, 1988) |
| "A new case of alcoholic ketoacidosis (AKA) is presented because of unusual clinical and biochemical features." | 1.32 | Major ketogenesis and the absence of an osmolar gap in an atypical case of alcoholic ketoacidosis. ( Azar, R; Dehon, B; Kim, I; Maisonneuve, N; Renom, G, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| de Landsheere, F | 1 |
| Saint-Marcoux, F | 1 |
| Haufroid, V | 1 |
| Dulaurent, S | 1 |
| Dewulf, JP | 1 |
| Boland, L | 1 |
| Laterre, PF | 1 |
| Hantson, P | 1 |
| Leibson, T | 1 |
| Davies, P | 1 |
| Nickel, C | 1 |
| Koren, G | 1 |
| Jahn, A | 1 |
| Bodreau, C | 1 |
| Farthing, K | 1 |
| Elbarbry, F | 1 |
| Schneir, AB | 1 |
| Rentmeester, L | 1 |
| Clark, RF | 1 |
| Cantrell, FL | 1 |
| Alavala, A | 1 |
| Ulliman, E | 1 |
| Shirazi, M | 1 |
| Szerlip, HM | 1 |
| Lim, R | 1 |
| Forward, KE | 1 |
| Kraut, JA | 1 |
| Beauchamp, GA | 1 |
| Valento, M | 1 |
| Ganesh, A | 1 |
| Audu, P | 1 |
| Yan, MT | 1 |
| Chau, T | 1 |
| Cheng, CJ | 1 |
| Lin, SH | 1 |
| Fung, EC | 1 |
| Crook, MA | 1 |
| Mullins, ME | 1 |
| Barnes, BJ | 1 |
| Renom, G | 1 |
| Maisonneuve, N | 1 |
| Kim, I | 1 |
| Dehon, B | 1 |
| Azar, R | 1 |
| JOHNSON, RB | 1 |
| Arroliga, AC | 1 |
| Shehab, N | 1 |
| McCarthy, K | 1 |
| Gonzales, JP | 1 |
| Bouchard, NC | 1 |
| Fulton, JA | 1 |
| Hoffman, RS | 1 |
| Maloney, G | 1 |
| Thompson, T | 1 |
| Mycyk, M | 1 |
| Zar, T | 1 |
| Yusufzai, I | 1 |
| Sullivan, A | 1 |
| Graeber, C | 1 |
| Parmar, MS | 1 |
| Tsao, YT | 1 |
| Tsai, WC | 1 |
| Yang, SP | 1 |
| Kauppinen, K | 1 |
| Gröhn, Y | 1 |
| Hamada, T | 1 |
| Ishii, T | 1 |
| Taguchi, S | 1 |
| Arbour, RB | 1 |
| Wilson, KC | 1 |
| Reardon, C | 1 |
| Farber, HW | 1 |
| Guillot, M | 1 |
| Bocquet, G | 1 |
| Eckart, P | 1 |
| Amiour, M | 1 |
| el-Hachem, C | 1 |
| Garnier, R | 1 |
| Galliot-Guilley, M | 1 |
| Haguenoer, JM | 1 |
| Lolin, Y | 1 |
| Francis, DA | 1 |
| Flanagan, RJ | 1 |
| Little, P | 1 |
| Lascelles, PT | 1 |
| Wierda, A | 1 |
| Verhoeff, J | 1 |
| Dorresteijn, J | 1 |
| Wensing, T | 1 |
| van Dijk, S | 1 |
| Ruegsegger, GJ | 1 |
| Schultz, LH | 1 |
3 reviews available for propylene glycol and Acidosis
| Article | Year |
|---|---|
Hyperosmolar metabolic acidosis in burn patients exposed to glycol based topical antimicrobials-A systematic review.
Topics: Acidosis; Anti-Infective Agents, Local; Glycols; Humans; Osmolar Concentration; Pharmaceutical Vehic | 2018 |
Diagnosis of toxic alcohols: limitations of present methods.
Topics: Acid-Base Equilibrium; Acidosis; Alcohols; Ethylene Glycol; Ethylene Glycols; Fomepizole; Humans; Me | 2015 |
Toxic Alcohol Ingestion: Prompt Recognition And Management In The Emergency Department.
Topics: 2-Propanol; Acidosis; Alcohols; Antidotes; Diagnosis, Differential; Disease Management; Emergency Se | 2016 |
1 trial available for propylene glycol and Acidosis
| Article | Year |
|---|---|
Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Critical Illness; Dose-Response Relationship, Drug; Female; | 2004 |
24 other studies available for propylene glycol and Acidosis
| Article | Year |
|---|---|
Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity.
Topics: Acidosis; Acidosis, Lactic; Ethanol; Ethylene Glycol; Female; Humans; Ketosis; Lactic Acid; Methanol | 2022 |
Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
Topics: Acid-Base Equilibrium; Acidosis; Alcoholism; Benzodiazepines; Diazepam; Female; Humans; Injections, | 2018 |
Toxicity following laundry detergent pod ingestion.
Topics: Acidosis; Alcohols; Consciousness Disorders; Deglutition Disorders; Detergents; Emergencies; Esophag | 2013 |
Quiz page October 2013: When things are not as they seem: a woman with anion gap metabolic acidosis after ingesting antifreeze.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Diagnosis, Differential; Female; Humans; Propylene Glycol; S | 2013 |
Laundry detergent pod ingestion.
Topics: Acidosis; Alcohols; Consciousness Disorders; Deglutition Disorders; Detergents; Esophagitis; Female; | 2013 |
Hyperosmolar, increased-anion-gap metabolic acidosis and hyperglycemia after etomidate infusion.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Anesthetics, Intravenous; Blood Chemical Analysis; Etomidate | 2008 |
Hunting down a double gap metabolic acidosis.
Topics: Acidosis; Aged; Alcoholism; Fatal Outcome; Female; Humans; Kidney Failure, Chronic; Lorazepam; Pneum | 2010 |
Closing in on the gaps.
Topics: Acidosis; Aged; Alcoholism; Female; Humans; Kidney Failure, Chronic; Lorazepam; Pneumonia, Ventilato | 2010 |
Hyperosmolar metabolic acidosis and intravenous Lorazepam.
Topics: Acidosis; Humans; Infusions, Intravenous; Lorazepam; Osmolar Concentration; Pharmaceutical Vehicles; | 2002 |
Major ketogenesis and the absence of an osmolar gap in an atypical case of alcoholic ketoacidosis.
Topics: Acidosis; Adult; Alcoholism; Female; Humans; Ketone Bodies; Ketosis; Osmolar Concentration; Propylen | 2003 |
The treatment of ketosis with glycerol and propylene glycol.
Topics: Acidosis; Animals; Cattle; Cattle Diseases; Glycerol; Glycols; Ketosis; Propylene Glycol | 1954 |
Propylene glycol accumulation after high-dose lorazepam: what have we learned?
Topics: Acid-Base Equilibrium; Acidosis; Critical Illness; Humans; Hypnotics and Sedatives; Infusions, Intra | 2005 |
Case 7-2006: a man with altered mental status and acute renal failure.
Topics: Acid-Base Equilibrium; Acidosis; Adenosine Triphosphatases; Analgesics; Cytochromes; Ethylene Glycol | 2006 |
Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam.
Topics: Acidosis; Acute Kidney Injury; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Drug Compounding; H | 2007 |
Re: Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam.
Topics: Acidosis; Acute Kidney Injury; Anti-Anxiety Agents; Drug Compounding; Humans; Lorazepam; Osmolar Con | 2007 |
A life-threatening double gap metabolic acidosis.
Topics: Acidosis; Alcoholism; Diagnosis, Differential; Humans; Hypnotics and Sedatives; Lorazepam; Male; Mid | 2008 |
Treatment of bovine ketosis with invert sugar, glucocorticoids, and propylene glycol.
Topics: Acidosis; Animals; Cattle; Cattle Diseases; Drug Therapy, Combination; Female; Fructose; Glucocortic | 1984 |
Blood changes of spontaneously ketotic cows before and four hours after administration of glucose, xylitol, 1,2-propanediol, or magnesium propionate.
Topics: Acidosis; Animals; Anti-Inflammatory Agents; Cattle; Cattle Diseases; Female; Glucose; Ketosis; Magn | 1982 |
Propylene glycol toxicity related to high-dose lorazepam infusion: case report and discussion.
Topics: Acidosis; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Male; Metabolic Cleara | 1999 |
Propylene glycol toxicity in a patient receiving intravenous diazepam.
Topics: Acidosis; Alcohol-Induced Disorders; Diazepam; Humans; Infusions, Intravenous; Male; Middle Aged; Ph | 2000 |
[Home environment and acute propylene glycol intoxication in a two-year old. An unusual case report].
Topics: Acidosis; Environment; Fatal Outcome; Feeding Behavior; Household Products; Humans; Infant; Male; Po | 2002 |
Cerebral depression due to propylene glycol in a patient with chronic epilepsy--the value of the plasma osmolal gap in diagnosis.
Topics: Acidosis; Adult; Epilepsy; Female; Humans; Osmolar Concentration; Propylene Glycol; Propylene Glycol | 1988 |
Effects of two glucocorticoids on milk yield and biochemical measurements in healthy and ketotic cows.
Topics: Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Dexamethasone; Female; Glucocorticoids; K | 1987 |
Use of a combination of propylene glycol and niacin for subclinical ketosis.
Topics: Acetates; Acidosis; Animals; Blood Glucose; Cattle; Cattle Diseases; Drug Therapy, Combination; Fatt | 1986 |