propylene glycol has been researched along with Acidosis, Lactic in 14 studies
Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.
Acidosis, Lactic: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis." | 8.12 | Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022) |
| "To report a case of probable propylene glycol (PG) toxicity in a patient receiving continuous infusion of pentobarbital for refractory status epilepticus." | 7.74 | Propylene glycol-induced lactic acidosis in a patient receiving continuous infusion pentobarbital. ( Forni, A; Miller, MA; Yogaratnam, D, 2008) |
| "To report a case of severe propylene glycol-induced lactic acidosis not attributable to renal dysfunction that was secondary to administration of high-dose intravenous lorazepam." | 7.73 | Propylene glycol-induced lactic acidosis in a patient with normal renal function: a proposed mechanism and monitoring recommendations. ( Mesler, EL; Neale, BW; Rebuck, JA; Weise, WJ; Young, M, 2005) |
| "Propylene glycol is a diluent found in many intravenous and oral drugs, including phenytoin, diazepam, and lorazepam." | 5.36 | Severe lactic acidosis after an iatrogenic propylene glycol overdose. ( Egelhoff, E; Heard, K; Zosel, A, 2010) |
| "The combination of propylene glycol ingestion and alcoholic ketoacidosis may have contributed to the severity of lactic acidosis." | 4.12 | Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. ( Boland, L; de Landsheere, F; Dewulf, JP; Dulaurent, S; Hantson, P; Haufroid, V; Laterre, PF; Saint-Marcoux, F, 2022) |
| " High PG levels can cause lactic acidosis." | 3.91 | Spectroscopic detection of brain propylene glycol in neonates: Effects of different pharmaceutical formulations of phenobarbital. ( Pouwels, PJW; van de Lagemaat, M; van de Pol, LA; Witjes, BCM; Zonnenberg, IA, 2019) |
| "To report a case of probable propylene glycol (PG) toxicity in a patient receiving continuous infusion of pentobarbital for refractory status epilepticus." | 3.74 | Propylene glycol-induced lactic acidosis in a patient receiving continuous infusion pentobarbital. ( Forni, A; Miller, MA; Yogaratnam, D, 2008) |
| "To report a case of severe propylene glycol-induced lactic acidosis not attributable to renal dysfunction that was secondary to administration of high-dose intravenous lorazepam." | 3.73 | Propylene glycol-induced lactic acidosis in a patient with normal renal function: a proposed mechanism and monitoring recommendations. ( Mesler, EL; Neale, BW; Rebuck, JA; Weise, WJ; Young, M, 2005) |
| "Ingestion of massive doses of propylene glycol, previously not reported as a cause of D-lactic acidosis, should be added to the differential diagnosis of this rare condition." | 3.72 | Unusual D-lactic acid acidosis from propylene glycol metabolism in overdose. ( Coucke, V; Couttenye, MM; Demey, HE; Jorens, PG; Schepens, PJ; Van Hoof, V; Verpooten, GA, 2004) |
| "For the treatment of postoperative seizures and prevention of brain edema, an etomidate drip was used in conjunction with phenytoin, diazepam, pentobarbital, and phenobarbital in a 70-year-old woman." | 3.68 | A case of propylene glycol toxic reaction associated with etomidate infusion. ( Bedichek, E; Kirschbaum, B, 1991) |
| " We found that this solvent, used in a commercially available IV nitroglycerin solution, may cause hyperosmolality, hemolysis and lactic acidosis." | 3.67 | Propylene glycol-induced side effects during intravenous nitroglycerin therapy. ( Bossaert, LL; Daelemans, RA; De Broe, ME; Demey, HE; Lakiere, FV; Schepens, PJ; Van Campenhout, CM; Verpooten, GA, 1988) |
| "Propylene glycol is a diluent found in many intravenous and oral drugs, including phenytoin, diazepam, and lorazepam." | 1.36 | Severe lactic acidosis after an iatrogenic propylene glycol overdose. ( Egelhoff, E; Heard, K; Zosel, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| de Landsheere, F | 1 |
| Saint-Marcoux, F | 1 |
| Haufroid, V | 1 |
| Dulaurent, S | 1 |
| Dewulf, JP | 1 |
| Boland, L | 1 |
| Laterre, PF | 1 |
| Hantson, P | 1 |
| Shah, H | 1 |
| Datta, D | 1 |
| Pouwels, PJW | 1 |
| van de Lagemaat, M | 1 |
| van de Pol, LA | 1 |
| Witjes, BCM | 1 |
| Zonnenberg, IA | 1 |
| Bulathsinghala, M | 1 |
| Keefer, K | 1 |
| Van de Louw, A | 1 |
| Miller, MA | 1 |
| Forni, A | 1 |
| Yogaratnam, D | 1 |
| Zosel, A | 1 |
| Egelhoff, E | 1 |
| Heard, K | 1 |
| Jorens, PG | 1 |
| Demey, HE | 2 |
| Schepens, PJ | 2 |
| Coucke, V | 1 |
| Verpooten, GA | 2 |
| Couttenye, MM | 1 |
| Van Hoof, V | 1 |
| Neale, BW | 1 |
| Mesler, EL | 1 |
| Young, M | 1 |
| Rebuck, JA | 1 |
| Weise, WJ | 1 |
| Arbour, R | 1 |
| Esparis, B | 1 |
| Parker, MG | 1 |
| Fraser, GL | 1 |
| Watson, DM | 1 |
| Riker, RR | 1 |
| Bedichek, E | 1 |
| Kirschbaum, B | 1 |
| Christopher, MM | 2 |
| Eckfeldt, JH | 1 |
| Eaton, JW | 2 |
| Perman, V | 1 |
| White, JG | 1 |
| Daelemans, RA | 1 |
| De Broe, ME | 1 |
| Van Campenhout, CM | 1 |
| Lakiere, FV | 1 |
| Bossaert, LL | 1 |
1 review available for propylene glycol and Acidosis, Lactic
| Article | Year |
|---|---|
Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature.
Topics: Acidosis, Lactic; Adult; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Administratio | 2016 |
13 other studies available for propylene glycol and Acidosis, Lactic
| Article | Year |
|---|---|
Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity.
Topics: Acidosis; Acidosis, Lactic; Ethanol; Ethylene Glycol; Female; Humans; Ketosis; Lactic Acid; Methanol | 2022 |
Acute-Onset Metabolic Acidosis in a Woman with
Topics: Acidosis, Lactic; Aged; Dermatomyositis; Female; Humans; Pneumonia, Pneumocystis; Propylene Glycol; | 2020 |
Spectroscopic detection of brain propylene glycol in neonates: Effects of different pharmaceutical formulations of phenobarbital.
Topics: Acidosis, Lactic; Brain; Drug Compounding; Female; Humans; Infant, Newborn; Intensive Care, Neonatal | 2019 |
Propylene glycol-induced lactic acidosis in a patient receiving continuous infusion pentobarbital.
Topics: Acidosis, Lactic; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Middle Aged; Pent | 2008 |
Severe lactic acidosis after an iatrogenic propylene glycol overdose.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Iatrogenic Disease; Infusions, Intravenous; Male; Pharmaceu | 2010 |
Unusual D-lactic acid acidosis from propylene glycol metabolism in overdose.
Topics: Acidosis, Lactic; Aged; Brain Diseases, Metabolic; Drug Overdose; Fatal Outcome; Humans; Male; Propy | 2004 |
Propylene glycol-induced lactic acidosis in a patient with normal renal function: a proposed mechanism and monitoring recommendations.
Topics: Acidosis, Lactic; Adult; Drug Carriers; Fatal Outcome; Female; Humans; Hypnotics and Sedatives; Kidn | 2005 |
Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure.
Topics: Acidosis, Lactic; Drug Combinations; Humans; Hypnotics and Sedatives; Hypoxia; Infusions, Intravenou | 2000 |
Removal of propylene glycol and correction of increased osmolar gap by hemodialysis in a patient on high dose lorazepam infusion therapy.
Topics: Acidosis, Lactic; Adult; Female; Humans; Infusions, Intravenous; Lorazepam; Osmolar Concentration; P | 2002 |
A case of propylene glycol toxic reaction associated with etomidate infusion.
Topics: Acidosis, Lactic; Aged; Anticonvulsants; Brain Edema; Drug Therapy, Combination; Epilepsy, Tonic-Clo | 1991 |
Propylene glycol ingestion causes D-lactic acidosis.
Topics: Acidosis, Lactic; Animals; Cats; Dose-Response Relationship, Drug; Female; Lactates; Lactic Acid; Ma | 1990 |
Propylene glycol-induced Heinz body formation and D-lactic acidosis in cats.
Topics: Acidosis, Lactic; Animal Feed; Animals; Cat Diseases; Cats; Erythrocyte Aging; Erythrocyte Deformabi | 1989 |
Propylene glycol-induced side effects during intravenous nitroglycerin therapy.
Topics: Acidosis, Lactic; Adult; Aged; Coronary Disease; Female; Hemolysis; Humans; Kidney; Male; Middle Age | 1988 |