propranolol and Uremia studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.

Research Excerpts

Excerpt	Relevance	Reference
"Propranolol is widely employed in hemodialysis patients for the control of renin-dependent hypertension."	7.66	Propranolol-associated hypoglycemia in patients on maintenance hemodialysis. ( Gelfand, M; Knepshield, J; Novello, A; Preuss, HG; Zarate, A, 1981)
" The common factor in all 5 patients was propranolol administration for the treatment of hypertension."	7.66	Hypoglycemia in chronic hemodialysis patients: association with propranolol use. ( Albin, J; Grajower, MM; Walter, L, 1980)
"The hemodynamic mechanism of the hypotensive effect of propranolol was studied by quantitative radiocardiography in 8 patients with dialysis-resistant hypertension."	7.66	Chronic hemodynamic effects of propranolol treatment in dialysis-refractory hypertension. ( Contini, C; Maggiore, Q; Monzani, G; Zoccali, C, 1978)
"Propranolol was the only antihypertensive drug common to all 16 patients."	5.26	Spurious hyperbilirubinemia in uremic patients on propranolol therapy. ( McKinney, TD; Stone, WJ; Warnock, LG, 1979)
"Propranolol is widely employed in hemodialysis patients for the control of renin-dependent hypertension."	3.66	Propranolol-associated hypoglycemia in patients on maintenance hemodialysis. ( Gelfand, M; Knepshield, J; Novello, A; Preuss, HG; Zarate, A, 1981)
" The common factor in all 5 patients was propranolol administration for the treatment of hypertension."	3.66	Hypoglycemia in chronic hemodialysis patients: association with propranolol use. ( Albin, J; Grajower, MM; Walter, L, 1980)
"The hemodynamic mechanism of the hypotensive effect of propranolol was studied by quantitative radiocardiography in 8 patients with dialysis-resistant hypertension."	3.66	Chronic hemodynamic effects of propranolol treatment in dialysis-refractory hypertension. ( Contini, C; Maggiore, Q; Monzani, G; Zoccali, C, 1978)
" In contrast, acute uremia did elicit a change in the bioavailability of orally administered S(-)-propranolol."	1.27	Altered S(--)-propranolol disposition in bilateral ureter-ligated rats. ( Laganière, S; Shen, DD, 1987)
" Steady-state daily dosage of propranolol averaged 225 +/- 36 mg (range, 80 to 400)."	1.26	Massive propranolol metabolite retention during maintenance hemodialysis. ( Stone, WJ; Walle, T, 1980)
"Propranolol was the only antihypertensive drug common to all 16 patients."	1.26	Spurious hyperbilirubinemia in uremic patients on propranolol therapy. ( McKinney, TD; Stone, WJ; Warnock, LG, 1979)
" A significant increase in the fraction of the dose available to the systemic circulation was also found, together with a modification of apparent plasma half-life and volume of distribution in regular dialysis patients during the dialysis day as compared with the after-dialysis day."	1.26	Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. ( Bianchetti, G; Brancaccio, D; Gomeni, R; Graziani, G; Leonetti, G; Manfrin, M; Morganti, A; Morselli, PL; Ponticelli, C; Sega, R, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	51 (98.08)	18.7374
1990's	1 (1.92)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Bianchetti, G	2
Brancaccio, D	4
Forette, F	1
Henry, JF	1
Hervy, MP	1
Ganansia, J	1
Gomeni, R	2
Kilborn, JR	1
Morselli, PL	2
Coevoet, B	6
Lambrey, G	1
de Frémont, JF	3
Hardin, JM	1
Desplan, C	4
Calmette, C	4
Makdassi, R	5
Andrejak, M	4
Moukhtar, MS	4
Fournier, A	6
Riegel, W	1
Stepinski, J	1
Hörl, WH	1
Heidland, A	1
Morinière, P	2
Sebert, JL	3
Decourt, S	2
Guéris, J	2
Fichtl, B	1
Gerdsmeier, W	1
Feinroth, MV	1
Goldstein, EJ	1
Josephson, A	1
Friedman, EA	1
Zarate, A	1
Gelfand, M	1
Novello, A	1
Knepshield, J	1
Preuss, HG	1
Decourcelle, PH	1
Kassouf, J	1
Roussel, A	1
Gheerbrand, JD	1
Schneck, DW	1
Pritchard, JF	1
Gibson, TP	2
Vary, JE	1
Hayes, AH	1
Grim, CE	1
Gheerbrant, JD	1
Tolani, M	2
Stone, WJ	2
Walle, T	1
Grajower, MM	1
Walter, L	1
Albin, J	1
Iaina, A	1
Solomon, S	1
Eliahou, H	1
Harken, AH	1
Roux, A	1
Baglin, A	1
Domart, M	1
Aubert, P	1
Flouvat, B	1
Fritel, D	1
Gherbrand, JD	1
Caillens, G	1
Galmozzi, C	2
Casati, S	2
Ponticelli, C	3
Eastwood, JB	1
Mogensen, CE	1
Lhoste, F	2
Drüeke, T	1
Larno, S	1
Man, NK	1
Zingraff, J	1
Jlngers, P	1
Boissier, JR	1
Cecchettin, M	1
Albertini, A	1
Luisetto, G	1
Heynen, G	1
Franchimont, P	1
Nivatpumin, T	2
Yipintsoi, T	2
Penpargkul, S	1
Scheuer, J	2
Wauters, JP	1
Schaller, MD	1
Brunner, HR	1
McKinney, TD	1
Warnock, LG	1
Kimata, S	1
Takahashi, S	1
Noda, H	1
Nakao, H	1
Hirosawa, K	1
Rurale, D	1
Belloli, S	1
Aroldi, A	1
Graziani, G	2
Maggiore, Q	2
Zoccali, C	2
Monzani, G	1
Contini, C	1
Kikawada, R	2
Noro, C	2
Morganti, A	1
Leonetti, G	1
Manfrin, M	1
Sega, R	1
Pessina, AC	1
Palatini, P	1
Pigato, R	1
Hlede, M	1
Tsuyusaki, T	1
Muramatsu, J	1
Kakubari, Y	1
Briggs, WA	1
Lowenthal, DT	1
Cirksena, WJ	1
Price, WE	1
Flamenbaum, W	1
Biagini, M	1
Misefari, M	1
Castellino, P	1
Bia, MJ	1
DeFronzo, RA	1
Bree, F	1
Souchet, T	1
Baatard, R	1
Fontenaille, C	1
Tillement, JP	1
Zawada, ET	1
Baylor, P	1
Shilo, S	1
Zonszein, J	1
Shamoon, H	1
Laganière, S	1
Shen, DD	2
Tiula, E	1
Neuvonen, PJ	1
Terao, N	1
Watt, DA	1
Smith, EC	1
Dhar, SK	1
Freedman, P	1
Onesti, G	1
Skrabal, F	1
Acchiardo, SR	1
Black, WD	1
Britt, L	1
McKeown, JW	1
Johnson, JG	1
Hatch, F	1
Seedat, YK	1
Naidoo, DN	1
Swenson, RS	2
Peterson, DT	1
Eshleman, M	1
Reaven, GM	2
Weisinger, J	1
Greene, W	1
Taylor, JB	1
Jameson, S	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pharmacokinetic Study of Propranolol, Losartan, and Eprosartan in Healthy Volunteers and Patients With Chronic Kidney Disease[NCT01087749]			Phase 1	24 participants (Actual)	Interventional	2010-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Pharmacokinetics of SL 75212 and propranolol in old age, uraemia and in healthy young adults [proceedings]. British journal of clinical pharmacology, 1980, Volume: 9, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Betaxolol; Female; Humans; Male; Propanolamines; Pr	1980
Adrenergic modulation of potassium metabolism in uremia. Kidney international, 1990, Volume: 37, Issue:2 Topics: Adult; Blood Pressure; Heart Rate; Humans; Metoprolol; Potassium; Propranolol; Uremia	1990
Renal hemodynamic changes after beta-blocker-diuretic combination therapy in azotemic hypertensive patients. The International journal of artificial organs, 1986, Volume: 9, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Aged; Drug Therapy, Combination; Glomerular Filtration Rate; Hum	1986

Article	Year
[Evidence, in uremic man, of the role of beta 2 adrenergic receptors in the secretion of parathyroid hormone and calcitonin (author's transl)]. Nephrologie, 1980, Volume: 1, Issue:1 Topics: Adult; Calcitonin; Female; Heart Rate; Humans; Kidney Diseases; Male; Metoprolol; Parathyroid Hormon	1980
Effect of hormones on hepatocyte gluconeogenesis in different models of acute uraemia. Nephron, 1982, Volume: 32, Issue:1 Topics: Acute Kidney Injury; Animals; Blood Glucose; Bucladesine; Dihydroxyacetone; Disease Models, Animal;	1982
Comparison of propranolol and atenolol in the control of hyperparathyroidism in uremia. Advances in experimental medicine and biology, 1982, Volume: 151 Topics: Adult; Aged; Atenolol; Bicarbonates; Female; Humans; Hyperparathyroidism, Secondary; Male; Middle Ag	1982
Increased plasma protein binding of propranolol in rabbits with acute renal failure. Life sciences, 1981, Jan-05, Volume: 28, Issue:1 Topics: Acute Kidney Injury; Animals; Blood Proteins; Creatinine; Female; Glycerol; Male; Phenytoin; Propran	1981
Infection complicating intrapericardial steroid instillation in uremic pericarditis. Clinical nephrology, 1981, Volume: 15, Issue:6 Topics: Adult; Drainage; Humans; Male; Minoxidil; Pericarditis; Propranolol; Staphylococcal Infections; Urem	1981
Propranolol-associated hypoglycemia in patients on maintenance hemodialysis. The International journal of artificial organs, 1981, Volume: 4, Issue:3 Topics: Adult; Humans; Hypertension; Hypoglycemia; Male; Propranolol; Renal Dialysis; Uremia	1981
Blockers of beta and H2 receptors and secondary hyperparathyroidism in uraemia. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1981, Volume: 18 Topics: Adult; Aged; Atenolol; Cimetidine; Female; Guanidines; Humans; Hyperparathyroidism, Secondary; Male;	1981
Effect of dose and uremia on plasma and urine profiles of propranolol metabolites. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:6 Topics: Absorption; Adult; Biotransformation; Half-Life; Humans; Kinetics; Liver; Male; Metabolic Clearance	1980
Management of malignant hypertension. Comprehensive therapy, 1980, Volume: 6, Issue:5 Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Clonidine; Diazoxide; Diuretics; Drug	1980
Effect of propranolol and metoprolol on parathyroid hormone and calcitonin secretions in uraemic patients. British medical journal, 1980, Jun-07, Volume: 280, Issue:6228 Topics: Adult; Calcitonin; Female; Heart Rate; Humans; Male; Metoprolol; Parathyroid Hormone; Propanolamines	1980
Massive propranolol metabolite retention during maintenance hemodialysis. Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:4 Topics: Adult; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Propranolol; Renal Dialysis; Ure	1980
Hypoglycemia in chronic hemodialysis patients: association with propranolol use. Nephron, 1980, Volume: 26, Issue:3 Topics: Adult; Aged; Female; Humans; Hypertension; Hypoglycemia; Male; Propranolol; Renal Dialysis; Uremia	1980
beta-Adrenergic blockade reduces the severity of acute renal failure in rats. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1976, Volume: 12 Topics: Acute Kidney Injury; Adrenergic beta-Antagonists; Angiotensin II; Animals; Creatinine; Disease Model	1976
[Study of the binding of beta blockers to plasma proteins. Therapeutic consequences]. Acquisitions medicales recentes, 1977 Topics: Acebutolol; Adrenergic beta-Antagonists; Blood Proteins; Dose-Response Relationship, Drug; Humans; H	1977
Acute effects of propranolol and metoprolol on plasma concentrations of parathyroid hormone and calcitonin in uraemic patients. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1979, Volume: 16 Topics: Adult; Bicarbonates; Blood Proteins; Calcitonin; Calcium; Female; Heart Rate; Humans; Hydrogen-Ion C	1979
Propranolol therapy for secondary hyperparathyroidism in uraemia. Lancet (London, England), 1978, Jul-01, Volume: 2, Issue:8079 Topics: Calcitonin; Drug Therapy, Combination; Humans; Hyperparathyroidism, Secondary; Metoprolol; Parathyro	1978
Propranolol in uraemic osteodystrophy. Lancet (London, England), 1978, Oct-28, Volume: 2, Issue:8096 Topics: Alkaline Phosphatase; Chronic Kidney Disease-Mineral and Bone Disorder; Humans; Parathyroid Hormone;	1978
Propranolol in uraemic osteodystrophy. Lancet (London, England), 1979, Feb-17, Volume: 1, Issue:8112 Topics: Chronic Kidney Disease-Mineral and Bone Disorder; Humans; Hyperparathyroidism, Secondary; Propranolo	1979
Diabetes and hypertension. Lancet (London, England), 1979, Feb-17, Volume: 1, Issue:8112 Topics: Blood Pressure; Diabetes Mellitus; Diabetic Nephropathies; Furosemide; Glomerular Filtration Rate; H	1979
Anti-beta adrenoreceptor blockade activity of plasma ultrafiltrate in two uraemic patients: effect of parathyroidectomy. Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1976, Volume: 25, Issue:5 Topics: Animals; Guinea Pigs; Heart; Heart Atria; Heart Rate; Humans; Hyperparathyroidism; In Vitro Techniqu	1976
[Calcitonin, gastrin, parathyroid hormone and the autonomic nervous system]. Minerva medica, 1978, May-26, Volume: 69, Issue:26 Topics: Calcitonin; Gastrins; Humans; Parathyroid Hormone; Propranolol; Receptors, Adrenergic; Receptors, Ad	1978
Increased cardiac contractility in acute uremia: interrelationships with hypertension. The American journal of physiology, 1975, Volume: 229, Issue:2 Topics: Animals; Blood Pressure; Blood Urea Nitrogen; Chlorides; Heart Rate; Hydrogen-Ion Concentration; Hyp	1975
[Discontinuation of chronic hemodialysis due to improved kidney function caused by the control of arterial hypertension]. Schweizerische medizinische Wochenschrift, 1979, Dec-08, Volume: 109, Issue:47 Topics: Adult; Creatinine; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Nitroprusside; Propr	1979
Spurious hyperbilirubinemia in uremic patients on propranolol therapy. Clinical chemistry, 1979, Volume: 25, Issue:10 Topics: Bilirubin; Dose-Response Relationship, Drug; Humans; Hyperbilirubinemia; Propranolol; Renal Dialysis	1979
[HIgh output heart failure (author's transl)]. Kokyu to junkan. Respiration & circulation, 1979, Volume: 27, Issue:12 Topics: Adult; Anemia; Animals; Arteriovenous Fistula; Cardiac Output; Dogs; Female; Hemodynamics; Humans; H	1979
Propranolol and uraemic osteodystrophy. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1979, Volume: 16 Topics: Alkaline Phosphatase; Calcitonin; Chronic Kidney Disease-Mineral and Bone Disorder; Humans; Hydroxyp	1979
Chronic hemodynamic effects of propranolol treatment in dialysis-refractory hypertension. Nephron, 1978, Volume: 22, Issue:4-6 Topics: Adult; Blood Pressure; Cardiac Output; Electrocardiography; Female; Hemodynamics; Humans; Hypertensi	1978
Clinical evaluation of myocardial contractility and its problems. Japanese circulation journal, 1977, Volume: 41, Issue:5 Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Humans; Hypertension; Isoproterenol; Myoc	1977
Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. Clinical pharmacokinetics, 1976, Volume: 1, Issue:5 Topics: Adult; Female; Humans; Kinetics; Male; Middle Aged; Propranolol; Renal Dialysis; Renin; Time Factors	1976
[Changes in kidney function during hypotensive treatment]. Bollettino della Societa italiana di cardiologia, 1976, Volume: 21, Issue:11 Topics: Adult; Aged; Clonidine; Dihydralazine; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazid	1976
Evaluation of myocardial contractility by the non-invasive method. Japanese circulation journal, 1975, Volume: 39, Issue:7 Topics: Aged; Atrial Fibrillation; Blood Pressure; Cardiac Output; Depression, Chemical; Digitalis Glycoside	1975
Propranolol in hypertensive dialysis patients: efficacy and compliance. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:5 Pt 1 Topics: Adolescent; Adult; Aged; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Patient Co	1975
Propranolol treatment of resistant arterial hypertension in patients on chronic dialysis. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1975, Volume: 11 Topics: Body Weight; Heart Rate; Humans; Hypertension, Renal; Propranolol; Renal Dialysis; Renin; Uremia	1975
Effects of moderate uremia on cardiac contractile responses. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 150, Issue:2 Topics: Animals; Blood Pressure; Calcium; Creatinine; Heart; Male; Myocardial Contraction; Organ Size; Phosp	1975
Inhibition of (-) [125I]-iodocyanopindolol binding to rat lung beta adrenoceptors by uremic plasma ultrafiltrates. Biochemical pharmacology, 1987, Oct-01, Volume: 36, Issue:19 Topics: Animals; Humans; In Vitro Techniques; Iodine Radioisotopes; Iodocyanopindolol; Kinetics; Lung; Male;	1987
Beta-adrenergic contribution to glucagon-induced glucose production and insulin secretion in uremia. The American journal of physiology, 1986, Volume: 251, Issue:3 Pt 1 Topics: Adult; Blood Glucose; Female; Glucagon; Humans; Insulin; Insulin Secretion; Kinetics; Male; Middle A	1986
Altered S(--)-propranolol disposition in bilateral ureter-ligated rats. Nephron, 1987, Volume: 46, Issue:3 Topics: Acute Kidney Injury; Administration, Oral; Animals; Blood Proteins; Injections, Intravenous; Intesti	1987
Effect of total drug concentration on the free fraction in uremic sera. Therapeutic drug monitoring, 1986, Volume: 8, Issue:1 Topics: Adult; Aged; Creatinine; Diazepam; Female; Humans; Male; Middle Aged; Orosomucoid; Pharmaceutical Pr	1986
Reduced extraction of I-propranolol by perfused rat liver in the presence of uremic blood. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:2 Topics: Acute Kidney Injury; Animals; Blood Glucose; Blood Proteins; Kinetics; Liver; Male; Metabolic Cleara	1985
Sensitivity to propranolol after digoxin intoxication. British medical journal, 1968, Aug-17, Volume: 3, Issue:5615 Topics: Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Atropine; Bradycardia; Cardiac Complexes, Premature	1968
Propranolol in the management of hypertension in a long-term dialysis program. JAMA, 1974, Sep-23, Volume: 229, Issue:13 Topics: Administration, Oral; Humans; Hypertension, Renal; Long-Term Care; Propranolol; Renal Dialysis; Urem	1974
Dialysis and volume control. Postgraduate medicine, 1974, Volume: 56, Issue:5 Topics: Humans; Hydralazine; Hypertension; Minoxidil; Nephrectomy; Propranolol; Renal Dialysis; Sodium; Ultr	1974
Half-life of plasma renin activity in normal subjects and in malignant hypertension. Klinische Wochenschrift, 1974, Dec-15, Volume: 52, Issue:24 Topics: Adolescent; Adult; Chronic Disease; Female; Half-Life; Humans; Hypertension, Malignant; Male; Nephre	1974
Experience with hemodialysis and renal transplantation in patients with malignant hypertension. Proceedings of the Clinical Dialysis and Transplant Forum, 1974, Issue:4 Topics: Acute Kidney Injury; Adult; Brain Diseases; Diazoxide; Diet Therapy; Female; Follow-Up Studies; Furo	1974
Evaluation of amiloride combined with hydrochlorothiazide (Moduretic) in the treatment of hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Jul-21, Volume: 47, Issue:28 Topics: Adult; Aged; Amiloride; Benzothiadiazines; Diuretics; Drug Combinations; Female; Guanethidine; Human	1973
Effect of acute uremia on various aspects of carbohydrate metabolism in dogs. Kidney international, 1973, Volume: 4, Issue:4 Topics: Acute Disease; Animals; Blood Glucose; Carbohydrate Metabolism; Creatinine; Dogs; Epinephrine; Fasti	1973
Comparison of the effects of metabolic acidosis and acute uremia on carbohydrate tolerance. Diabetes, 1972, Volume: 21, Issue:11 Topics: Acidosis; Acute Disease; Ammonium Chloride; Animals; Blood Glucose; Dogs; Epinephrine; Female; Gluco	1972
[Effects of Inderal in the treatment of uremic hypertension]. Nordisk medicin, 1971, Nov-08, Volume: 86, Issue:44 Topics: Adult; Allopurinol; Diabetic Coma; Drug Combinations; Drug Interactions; Female; Humans; Hydralazine	1971

propranolol and Uremia

Research Excerpts

Research

Studies (52)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies