propranolol has been researched along with Trypanosomiasis, African in 2 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compound was orally bioavailable and displayed good plasma and brain exposure in mice." | 1.40 | Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis. ( Brun, R; Buckner, FS; Chatterjee, AK; Creason, SA; Duster, NA; Gelb, MH; Gillespie, JR; Glynne, R; Hulverson, MA; McQueen, J; Molteni, V; Nagendar, P; Nagle, A; Norcross, NR; Ranade, RM; Supek, F; Tatipaka, HB; Wenzler, T, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tatipaka, HB | 1 |
| Gillespie, JR | 1 |
| Chatterjee, AK | 1 |
| Norcross, NR | 1 |
| Hulverson, MA | 1 |
| Ranade, RM | 1 |
| Nagendar, P | 1 |
| Creason, SA | 1 |
| McQueen, J | 1 |
| Duster, NA | 1 |
| Nagle, A | 1 |
| Supek, F | 1 |
| Molteni, V | 1 |
| Wenzler, T | 1 |
| Brun, R | 1 |
| Glynne, R | 1 |
| Buckner, FS | 1 |
| Gelb, MH | 1 |
| Thompson, AM | 1 |
| Marshall, AJ | 1 |
| Maes, L | 1 |
| Yarlett, N | 1 |
| Bacchi, CJ | 1 |
| Gaukel, E | 1 |
| Wring, SA | 1 |
| Launay, D | 1 |
| Braillard, S | 1 |
| Chatelain, E | 1 |
| Mowbray, CE | 1 |
| Denny, WA | 1 |
2 other studies available for propranolol and Trypanosomiasis, African
| Article | Year |
|---|---|
Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.
Topics: Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Cell Membrane Permeability | 2014 |
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mic | 2018 |