propranolol has been researched along with Schistosoma mansoni Infection in 7 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When propranolol was administered orally as 20 mg/kg daily doses for two weeks at 6, 10, 14 and 18 weeks p." | 5.28 | Gastro-vascular and micro-vascular changes in chronic murine schistosomiasis mansoni-response to propranolol. ( el-Aggan, HA; el-Gebaly, WM; Khedr, MM, 1992) |
| "The best results obtained in treatment of portal hypertension were: esophagogastric devascularization and splenectomy (EGDS), although risk of rebleeding persists; classical (proximal) splenorenal shunt (SRS) should be abandoned; distal splenorenal shunt may complicate with hepatic encephalopathy, although later and in a lower percentage than in SRS." | 2.38 | Portal hypertension in schistosomiasis: pathophysiology and treatment. ( Da Silva, LC, 1992) |
| "All of them had high-risk esophageal varices at endoscopy." | 1.35 | Propranolol reduces variceal pressure and wall tension in schistosomiasis presinusoidal portal hypertension. ( Bittencourt, PL; Carrilho, FJ; da Rocha, EC; Dos Santos Bomfim, V; Farias, AQ; Kassab, F; Vezozzo, DC, 2009) |
| "Management of patients with bleeding oesophageal varices comprises of mainly diagnostic endoscopy, sclerotherapy and band ligation." | 1.32 | Can somatostatin control acute bleeding from oesophageal varices in Schistosoma mansoni patients?[ISRCTN63456799]. ( Chatterjee, S; Van Marck, E, 2004) |
| " It was decided that patients whose portal pressure was reduced by 30% with the use of the drug would not undergo surgery and that treatment would consist of the chronic use of propranolol, associated with sclerosis of esophageal varices." | 1.30 | Systemic and hepatic hemodynamics in hepatosplenic Manson's schistosomiasis with and without propranolol. ( Alfieri, F; Baía, CE; Beer, A; Mies, S; Neto, OB; Pereira, LM; Raia, S; Sette, MJ, 1997) |
| "When propranolol was administered orally as 20 mg/kg daily doses for two weeks at 6, 10, 14 and 18 weeks p." | 1.28 | Gastro-vascular and micro-vascular changes in chronic murine schistosomiasis mansoni-response to propranolol. ( el-Aggan, HA; el-Gebaly, WM; Khedr, MM, 1992) |
| "Propranolol was administered in drinking water to 20 animals for a period of 6 wk at a dose of 10 mg." | 1.28 | Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension. ( Bhatnagar, R; Dayal, Y; Groszmann, RJ; Mosca, PG; Reuben, A; Rojkind, M; Sarin, SK; Stadecker, MJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bustinduy, AL | 1 |
| Luzinda, K | 1 |
| Mpoya, S | 1 |
| Gothard, P | 1 |
| Stone, N | 1 |
| Wright, S | 1 |
| Stothard, JR | 1 |
| Farias, AQ | 1 |
| Kassab, F | 1 |
| da Rocha, EC | 1 |
| Dos Santos Bomfim, V | 1 |
| Vezozzo, DC | 1 |
| Bittencourt, PL | 1 |
| Carrilho, FJ | 1 |
| Chatterjee, S | 1 |
| Van Marck, E | 1 |
| Mies, S | 1 |
| Neto, OB | 1 |
| Beer, A | 1 |
| Baía, CE | 1 |
| Alfieri, F | 1 |
| Pereira, LM | 1 |
| Sette, MJ | 1 |
| Raia, S | 1 |
| Da Silva, LC | 1 |
| el-Aggan, HA | 1 |
| el-Gebaly, WM | 1 |
| Khedr, MM | 1 |
| Sarin, SK | 1 |
| Groszmann, RJ | 1 |
| Mosca, PG | 1 |
| Rojkind, M | 1 |
| Stadecker, MJ | 1 |
| Bhatnagar, R | 1 |
| Reuben, A | 1 |
| Dayal, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blind Study of Timolol (A Nonselective Beta-Adrenergic Blocker) vs Placebo to Prevent Complications of Hepatic Portal Hypertension in Patients With Cirrhosis[NCT00006398] | Phase 3 | 213 participants (Actual) | Interventional | 1993-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propranolol and Schistosoma mansoni Infection
| Article | Year |
|---|---|
Portal hypertension in schistosomiasis: pathophysiology and treatment.
Topics: Animals; Cricetinae; Esophageal and Gastric Varices; Follow-Up Studies; Gastrointestinal Hemorrhage; | 1992 |
6 other studies available for propranolol and Schistosoma mansoni Infection
| Article | Year |
|---|---|
Endomyocardial fibrosis (EMF) in a Ugandan child with advanced hepatosplenic schistosomiasis: coincidence or connection?
Topics: Animals; Anthelmintics; Child; Endomyocardial Fibrosis; Feces; Humans; Liver Diseases; Male; Praziqu | 2014 |
Propranolol reduces variceal pressure and wall tension in schistosomiasis presinusoidal portal hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Animals; Endosonography; Esophageal and Gastric Varices; Esophag | 2009 |
Can somatostatin control acute bleeding from oesophageal varices in Schistosoma mansoni patients?[ISRCTN63456799].
Topics: Adolescent; Anthelmintics; Antihypertensive Agents; Child; Drug Therapy, Combination; Esophageal and | 2004 |
Systemic and hepatic hemodynamics in hepatosplenic Manson's schistosomiasis with and without propranolol.
Topics: Adrenergic beta-Antagonists; Adult; Blood Flow Velocity; Esophageal and Gastric Varices; Hemodynamic | 1997 |
Gastro-vascular and micro-vascular changes in chronic murine schistosomiasis mansoni-response to propranolol.
Topics: Animals; Chronic Disease; Gastric Mucosa; Mice; Propranolol; Schistosomiasis mansoni; Stomach | 1992 |
Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension.
Topics: Animals; Blood Pressure; Chronic Disease; Collagen; Granuloma; Heart Rate; Hemodynamics; Hepatic Art | 1991 |