propranolol and Pyrexia studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Research Excerpts

Excerpt	Relevance	Reference
" The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation."	7.70	Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999)
"The propranolol was continued until all signs of autonomic dysfunction abated."	5.29	Fever of central origin in traumatic brain injury controlled with propranolol. ( Meythaler, JM; Stinson, AM, 1994)
" The beta-blocker propranolol, known for its effectiveness on cutaneous hemangiomas, is also proving useful for the treatment of subglottic or visceral hemangiomas."	3.78	[Pediatrics]. ( Chevallay, M; de Buys Roessingh, A; El Ezzi, O; Fischer, CJ; Gehri, M; Giannoni, E; Hauschild, M; Hohlfeld, J; Pauchard, JY; Seneggen, E; Tolsa, JF; Truttmann, AC, 2012)
" The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation."	3.70	Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999)
" Yohimbine, in small doses, but not prazosin and propranolol, when injected into the cerebral ventricles, attenuated the hypothermia evoked by i."	3.67	Nature of hypo- and hyperthermia induced by the calcium antagonist nicardipine. ( Beleslin, DB; Jovanović-Micić, D; Samardzić, R, 1987)
" Hypothyroidism was induced by treatment with propylthiouracil (100 or 200 mg/kg body wt."	3.67	The development of a febrile response to pyrogen in the thyroid-deficient rabbit. ( Macari, M; Pelá, IR; Silva, CA, 1987)
"Treatment with prazosin (1mg/kg, i."	1.36	Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain. ( Bhide, N; Gudelsky, GA; Pachmerhiwala, R; Straiko, M, 2010)
"Propranolol pretreatment blunted the initial decrease in blood glutamate, and thereafter had no effect when compared with control and treatment groups."	1.36	The effect of hyperthermia on blood glutamate levels. ( Artru, AA; Dubilet, M; Gruenbaum, SE; Gurevich, B; Leibowitz, A; Ohayon, S; Shaked, G; Shapira, Y; Teichberg, VI; Zlotnik, A, 2010)
"Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent."	1.31	Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001)
"The propranolol was continued until all signs of autonomic dysfunction abated."	1.29	Fever of central origin in traumatic brain injury controlled with propranolol. ( Meythaler, JM; Stinson, AM, 1994)
" After adrenalectomy, neither 5 mg/kg nor chronic administration of 20 mg/kg morphine produced previously demonstrated hyperthermia."	1.26	Bole of adrenals in morphine-induced hyperthermia in restrained rats. ( Wallenstein, MC, 1982)
"Propranolol prevented the increase in PRA."	1.26	Renal vascular response to heat stress in baboons--role of renin-angiotensin. ( Eisman, MM; Rowell, LB, 1977)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (63.46)	18.7374
1990's	10 (19.23)	18.2507
2000's	4 (7.69)	29.6817
2010's	4 (7.69)	24.3611
2020's	1 (1.92)	2.80

Authors	Studies
Kessler, RR	1
Schiml, PA	1
McGraw, SM	1
Tomlin, EN	1
Hoeferlin, MJ	1
Deak, T	1
Hennessy, MB	1
Alawi, KM	1
Aubdool, AA	1
Liang, L	1
Wilde, E	1
Vepa, A	1
Psefteli, MP	1
Brain, SD	1
Keeble, JE	1
Marks, A	1
Vianna, DM	1
Carrive, P	1
Pachmerhiwala, R	1
Bhide, N	1
Straiko, M	1
Gudelsky, GA	1
Zlotnik, A	1
Gurevich, B	1
Artru, AA	1
Gruenbaum, SE	1
Dubilet, M	1
Leibowitz, A	1
Shaked, G	1
Ohayon, S	1
Shapira, Y	1
Teichberg, VI	1
Fischer, CJ	1
Giannoni, E	1
Truttmann, AC	1
Tolsa, JF	1
Chevallay, M	1
El Ezzi, O	1
Seneggen, E	1
Hohlfeld, J	1
de Buys Roessingh, A	1
Pauchard, JY	1
Gehri, M	1
Hauschild, M	1
Charles, RA	1
Goh, SY	1
Oh, SJ	1
Hong, YK	1
Song, EK	1
Groza, P	1
Ardeleanu, S	1
Lazăr, I	1
Lin, MT	1
Wu, JJ	1
Chandra, A	1
Tsay, BL	1
Mittleman, HS	1
Mittleman, RE	1
Elser, B	1
Ferguson, AV	1
Bauce, L	1
Veale, WL	2
Cooper, KE	2
Wallenstein, MC	1
Duncan, AW	1
Tibballs, J	1
Sutherland, SK	1
Nonogaki, K	1
Iguchi, A	1
Sakamoto, N	1
Meythaler, JM	2
Stinson, AM	1
Melnikov, AL	1
Løkebø, JE	1
Lathrop, DA	1
Helgesen, KG	1
Kappel, M	2
Poulsen, TD	2
Hansen, MB	2
Galbo, H	2
Pedersen, BK	2
Wilkinson, R	1
Guin-Renfroe, S	1
Nisijima, K	1
Yoshino, T	1
Yui, K	1
Katoh, S	1
Bantutova, I	1
Székely, M	1
Eisman, MM	1
Rowell, LB	1
King, J	1
Barnett, PS	1
Kew, MC	1
Gronert, GA	1
Theye, RA	1
Milde, JH	1
Tinker, JH	1
Blatteis, CM	1
Burks, TF	1
VanInwegen, RG	1
Horwitz, BA	1
Hanes, GE	1
Cooper, AL	2
Horan, MA	1
Little, RA	1
Rothwell, NJ	2
Nezhentsev, MV	1
Aleksandrov, SI	1
Fyda, DM	1
Beleslin, DB	1
Jovanović-Micić, D	1
Samardzić, R	1
Benzi, RH	1
Shibata, M	1
Seydoux, J	1
Girardier, L	1
Gordon, NF	1
Myburgh, DP	1
Schwellnus, MP	1
van Rensburg, JP	1
Nissen, LR	1
Storm, K	1
Christensen, P	1
Bernsen, A	1
Lee, KS	1
Kim, K	1
Hur, KB	1
Kim, CK	1
Macari, M	1
Pelá, IR	1
Silva, CA	1
Frick, MH	1
Heikkilä, J	1
Kahanpää, A	1
Simmons, AV	1
Carr, D	1
Ross, EJ	1
Jori, A	2
Carrara, C	1
Paglialunga, S	2
Garattini, S	2
Dixit, KS	2
Dhasmana, KM	2
Sinha, JN	2
Bhargava, KP	2
Varagić, VM	1
Zugić, M	1
Kazić, T	1
Newmark, SR	1
Himathongkam, T	1
Shane, JM	1
Warner, H	1
Ovcharov, R	1
Aleksieva, S	1
van Miert, AS	1
Veninga, TS	1
Moia, B	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Controlling Hyperadrenergic Activity in Neurologic Injury[NCT01343329]			Phase 1/Phase 2	0 participants (Actual)	Interventional	2011-07-31	Withdrawn (stopped due to Unable to enroll subjects that fit study criteria.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration. European journal of applied physiology and occupational physiology, 1998, Volume: 77, Issue:1-2 Topics: Adult; Cross-Over Studies; Fever; Hot Temperature; Humans; Immersion; Killer Cells, Natural; Kinetic	1998
Immune changes during whole body hot water immersion: the role of growth hormone. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 1997, Volume: 4, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Body Temperature; Endorphins; Fever; Growth Hormone; Hormone Ant	1997
The role of propranolol in the preoperative preparation of patients with Graves' disease. Surgery, gynecology & obstetrics, 1986, Volume: 162, Issue:4 Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fever; Follow-Up Studies; Graves	1986

Article	Year
Examination of the role of adrenergic receptor stimulation in the sensitization of neuroinflammatory-based depressive-like behavior in isolated Guinea pig pups. Stress (Amsterdam, Netherlands), 2023, Volume: 26, Issue:1 Topics: Animals; Behavior, Animal; Fever; Guinea Pigs; Hydrocortisone; Mice; Propranolol; Rats; Receptors, A	2023
The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:10 Topics: Acrylamides; Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Body Tem	2015
Nonshivering thermogenesis without interscapular brown adipose tissue involvement during conditioned fear in the rat. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:4 Topics: Adipose Tissue, Brown; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Cold Temperature; Con	2009
Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain. European journal of pharmacology, 2010, Oct-10, Volume: 644, Issue:1-3 Topics: Animals; Brain; Fever; Fluoxetine; Glucose; Glycogenolysis; Male; N-Methyl-3,4-methylenedioxyampheta	2010
The effect of hyperthermia on blood glutamate levels. Anesthesia and analgesia, 2010, Volume: 111, Issue:6 Topics: Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Bicarbonates; Blood Glucose; Body Te	2010
[Pediatrics]. Revue medicale suisse, 2012, Jan-11, Volume: 8, Issue:323 Topics: Adrenergic beta-Agonists; Bacterial Infections; Breast Feeding; Enterocolitis, Necrotizing; Fever; G	2012
Not just gastroenteritis: thyroid storm unmasked. Emergency medicine Australasia : EMA, 2004, Volume: 16, Issue:3 Topics: Anti-Arrhythmia Agents; Antithyroid Agents; Chills; Diabetes Complications; Diabetes Mellitus; Diagn	2004
Paroxysmal autonomic dysregulation with fever that was controlled by propranolol in a brain neoplasm patient. The Korean journal of internal medicine, 2007, Volume: 22, Issue:1 Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Autonomic Nervous System Diseases; Body Temperatur	2007
Plasma renin activity in hyperthermic rats. Physiologie (Bucarest), 1981, Volume: 18, Issue:2 Topics: Aldosterone; Animals; Fever; Hexamethonium; Hexamethonium Compounds; Male; Propranolol; Rats; Renin	1981
A norepinephrine-cyclic AMP link in the hypothalamic pathways which mediate fever induced by endotoxin and prostaglandin E2 in the rat. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:1 Topics: Aminophylline; Animals; Body Temperature Regulation; Bucladesine; Cyclic AMP; Dinoprostone; Endotoxi	1982
Cocaine. The American journal of nursing, 1984, Volume: 84, Issue:9 Topics: Cocaine; Emergencies; Fever; Humans; Hypertension; Propranolol; Seizures; Substance-Related Disorder	1984
An investigation of the age-related deficits in the febrile response of the rabbit. The American journal of physiology, 1983, Volume: 245, Issue:3 Topics: Aging; Animals; Body Temperature; Body Temperature Regulation; Endotoxins; Fever; Kinetics; Norepine	1983
Bole of adrenals in morphine-induced hyperthermia in restrained rats. Life sciences, 1982, Apr-12, Volume: 30, Issue:15 Topics: Adrenal Glands; Animals; Body Temperature; Female; Fever; Guanethidine; Male; Morphine; Pentolinium	1982
Effects of Sydney funnel-web spider envenomation in monkeys, and their clinical implications. The Medical journal of Australia, 1980, Oct-18, Volume: 2, Issue:8 Topics: Acidosis; Acute Disease; Animals; Arrhythmias, Cardiac; Catecholamines; Cats; Dogs; Fever; Hypertens	1980
Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha in rats. European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2 Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Body Temperature; Dinoprost; Fever; Hyperglyce	1994
Fever of central origin in traumatic brain injury controlled with propranolol. Archives of physical medicine and rehabilitation, 1994, Volume: 75, Issue:7 Topics: Accidents, Traffic; Adolescent; Adult; Body Temperature Regulation; Brain Injuries; Female; Fever; H	1994
Alteration of the cardiac effects of isoproterenol and propranolol by hypothermia in isolated rat atrium. General pharmacology, 1996, Volume: 27, Issue:4 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atrial Function; Electric Stimulatio	1996
Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. Brain injury, 1999, Volume: 13, Issue:12 Topics: Adolescent; Amantadine; Brain Injuries; Dopamine Agents; Dopamine Antagonists; Fever; Haloperidol; H	1999
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain research, 2001, Jan-26, Volume: 890, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature	2001
[Effect of pharmacological agents and coagulation of the n. raphe dorsalis on morphine effects]. Eksperimentalna meditsina i morfologiia, 1979, Volume: 18, Issue:4 Topics: Animals; Brain Stem; Catalepsy; Cyproheptadine; Dimenhydrinate; Electrocoagulation; Female; Fencloni	1979
Central and peripheral adrenergic mechanisms in endotoxin fever and newborn guinea pigs. Acta physiologica Academiae Scientiarum Hungaricae, 1979, Volume: 54, Issue:3 Topics: alpha-Methyltyrosine; Animals; Animals, Newborn; Body Temperature; Endotoxins; Escherichia coli; Fev	1979
Renal vascular response to heat stress in baboons--role of renin-angiotensin. Journal of applied physiology: respiratory, environmental and exercise physiology, 1977, Volume: 43, Issue:4 Topics: Angiotensin II; Animals; Blood Pressure; Body Temperature; Fever; Haplorhini; Hot Temperature; Kidne	1977
Drug-induced hyperpyrexia. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Aug-04, Volume: 56, Issue:5 Topics: Bromazepam; Diazepam; Female; Fever; Heat Exhaustion; Humans; Middle Aged; Monoamine Oxidase Inhibit	1979
Catecholamine stimulation of myocardial oxygen consumption in porcine malignant hyperthermia. Anesthesiology, 1978, Volume: 49, Issue:5 Topics: Animals; Cardiomyopathies; Catecholamines; Fever; Halothane; Isoproterenol; Oxygen Consumption; Prop	1978
Effect of propranolol on endotoxin-induced pyrogenesis in newborn and adult guinea pigs. Journal of applied physiology, 1976, Volume: 40, Issue:1 Topics: Adipose Tissue, Brown; Age Factors; Animals; Body Temperature; Cold Temperature; Endotoxins; Female;	1976
Phentolamine inhibition of morphine induced hyperthermia in cats. Proceedings of the Western Pharmacology Society, 1975, Volume: 18 Topics: Animals; Cats; Female; Fever; Haloperidol; Hydroxydopamines; Male; Morphine; Phentolamine; Propranol	1975
Propranolol and pyrogen effects of shivering and nonshivering thermogenesis in rats. The American journal of physiology, 1976, Volume: 230, Issue:3 Topics: Animals; Body Temperature; Depression, Chemical; Electrodes, Implanted; Endotoxins; Fever; Injection	1976
Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade. Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 72, Issue:6 Topics: Acute-Phase Reaction; Adolescent; Adult; Female; Fever; Heart Rate; Humans; Male; Metabolism; Propra	1992
[Febrifugal activity of acupuncture and its strengthening by the effects of anaprilin]. Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 113, Issue:3 Topics: Acupuncture Therapy; Animals; Fever; Lipopolysaccharides; Male; Propranolol; Pyrogens; Rabbits	1992
Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats. The American journal of physiology, 1991, Volume: 261, Issue:6 Pt 1 Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antibodies; Capsaicin; Central Nervous S	1991
Contribution of brown adipose tissue to central PGE1-evoked hyperthermia in rats. The American journal of physiology, 1991, Volume: 260, Issue:1 Pt 2 Topics: Adipose Tissue; Adipose Tissue, Brown; Alprostadil; Animals; Blood Pressure; Cardiovascular Physiolo	1991
Nature of hypo- and hyperthermia induced by the calcium antagonist nicardipine. Archives internationales de physiologie et de biochimie, 1987, Volume: 95, Issue:4 Topics: Animals; Body Temperature Regulation; Cats; Fever; Hypothermia; Injections, Intraventricular; Ion Ch	1987
Prepontine knife cut-induced hyperthermia in the rat. Effect of chemical sympathectomy and surgical denervation of brown adipose tissue. Pflugers Archiv : European journal of physiology, 1988, Volume: 411, Issue:6 Topics: Adipose Tissue, Brown; Animals; Body Temperature; Body Temperature Regulation; Colon; Denervation; D	1988
Effect of beta-blockade on exercise core temperature in coronary artery disease patients. Medicine and science in sports and exercise, 1987, Volume: 19, Issue:6 Topics: Adult; Blood Pressure; Body Temperature; Body Temperature Regulation; Coronary Disease; Exercise Tes	1987
[Thyrotoxic crisis with fatal course in a child]. Ugeskrift for laeger, 1987, Sep-21, Volume: 149, Issue:39 Topics: Child, Preschool; Dantrolene; Drug Therapy, Combination; Female; Fever; Humans; Propranolol; Propylt	1987
The development of a febrile response to pyrogen in the thyroid-deficient rabbit. Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:6 Topics: Animals; Body Temperature; Fever; Hypothyroidism; Lipopolysaccharides; Male; Propranolol; Propylthio	1987
Combined parasympathetic and beta-receptor blockade as a clinical test. Acta medica Scandinavica, 1967, Volume: 182, Issue:5 Topics: Adolescent; Adult; Age Factors; Aged; Anemia; Anxiety; Atropine; Female; Fever; Heart Diseases; Hear	1967
Case of self-poisoning with multiple antidepressant drugs. Lancet (London, England), 1970, Jan-31, Volume: 1, Issue:7640 Topics: Adult; Antidepressive Agents; Blood Pressure; Cheese; Dibenzocycloheptenes; Fever; Humans; Intubatio	1970
Pharmacological studies on modaline sulphate (w 3207). The Journal of pharmacy and pharmacology, 1965, Volume: 17, Issue:11 Topics: Antidepressive Agents; Desipramine; Dibenzylchlorethamine; Dihydroxyphenylalanine; Fever; Hydrazines	1965
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine. Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 165, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpro	1967
Role of catecholamines in fatal hyperpyrexia induced by imipramine in MAOI treated rabbits. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Chlorisondamine; Chlorpromazine; Drug Antagoni	1970
The hypothermic effect of eserine in the rat. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1971, Volume: 270, Issue:4 Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Body Temperature; Body Temperature Regulation; Fema	1971
Hyperthyroid crisis. JAMA, 1974, Oct-28, Volume: 230, Issue:4 Topics: Adrenal Cortex Hormones; Aspirin; Atrial Fibrillation; Diarrhea; Fever; Guanethidine; Humans; Iodide	1974
[Pharmacologic analysis of some metabolic processes in rabbits during pyrogenic reaction]. Eksperimentalna meditsina i morfologiia, 1973, Volume: 12, Issue:4 Topics: Animals; Blood Glucose; Body Temperature Regulation; Carbohydrate Metabolism; Endotoxins; Fever; Pro	1973
Inhibition of gastric motility by endotoxin (bacterial lipopolysaccharide) in conscious goats and modification of this response by splanchnectomy, adrenalectomy or adrenergic blocking agents. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 193, Issue:2 Topics: Adrenalectomy; Animals; Denervation; Depression, Chemical; Desoxycorticosterone; Dibenzylchlorethami	1971
The role of monoamines in the hyperthermia produced in cats and rabbits by irradiation of the hypothalamic area. British journal of pharmacology, 1972, Volume: 45, Issue:1 Topics: Animals; Catecholamines; Cats; Ergotamine; Fever; Hypothalamus; Injections, Intraperitoneal; Propran	1972
Cardiac neuroses: recognition and management. Cardiovascular clinics, 1971, Volume: 2, Issue:3 Topics: Angina Pectoris; Antidepressive Agents; Aortic Valve; Bromides; Cardiomyopathy, Hypertrophic; Celiac	1971
Antagonism of imipramine induced fatal hyperpyrexia in MAO inhibitor treated rabbits. Japanese journal of pharmacology, 1969, Volume: 19, Issue:4 Topics: Amino Alcohols; Animals; Body Temperature; Drug Antagonism; Female; Fever; Imipramine; Male; Monoami	1969

propranolol and Pyrexia

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