propranolol has been researched along with Porphyrias in 24 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DL-Propranolol was shown to reduce the elevated urinary excretion of porphyrins and their precursors in a patient with variegate porphyria and to improve the patient's symptoms during attacks of the disease." | 7.65 | Reduction of porphyrin excretion in porphyria variegata by propranolol. A case report. ( Atsmon, A; Blum, I, 1976) |
| "Treatment with propranolol hydrochloride (Deralin [Israel]; Inderal, comparable US product) intravenously administered in a total dose of 284 mg during a period of 18 hours, was followed by clinical remission associated with a decline in urinary excretion of porphyrin precursors." | 5.26 | Treatment of acute intermittent porphyria with large doses of propranolol. ( Atsmon, A; Douer, D; Pinkhas, J; Weinberger, A, 1978) |
| "Propranolol, when given in high dosage to rats, did not induce an increase in hepatic delta-aminolaevulic acid synthetase, an enzyme which is raised in human and drug-induced animal porphyria." | 5.25 | Acute intermittent porphyria: response of tachycardia and hypertension to propranolol. ( Beattie, AD; Goldberg, A; Moore, MR; Ward, RL, 1973) |
| "The effect of DL-propranolol on 3',5'-diethoxycarbonyl-1,4-dihydrocollidine-induced experimental porphyria was studied." | 3.65 | The effect of beta-adrenergic blocking agents on experimental porphyria induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo and in vitro. ( Atsmon, A; Epstein, O; Schoenfeld, N, 1976) |
| "DL-Propranolol was shown to reduce the elevated urinary excretion of porphyrins and their precursors in a patient with variegate porphyria and to improve the patient's symptoms during attacks of the disease." | 3.65 | Reduction of porphyrin excretion in porphyria variegata by propranolol. A case report. ( Atsmon, A; Blum, I, 1976) |
| "Treatment with propranolol hydrochloride (Deralin [Israel]; Inderal, comparable US product) intravenously administered in a total dose of 284 mg during a period of 18 hours, was followed by clinical remission associated with a decline in urinary excretion of porphyrin precursors." | 1.26 | Treatment of acute intermittent porphyria with large doses of propranolol. ( Atsmon, A; Douer, D; Pinkhas, J; Weinberger, A, 1978) |
| "Propranolol, when given in high dosage to rats, did not induce an increase in hepatic delta-aminolaevulic acid synthetase, an enzyme which is raised in human and drug-induced animal porphyria." | 1.25 | Acute intermittent porphyria: response of tachycardia and hypertension to propranolol. ( Beattie, AD; Goldberg, A; Moore, MR; Ward, RL, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (91.67) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kostrzewska, E | 1 |
| Catania, A | 1 |
| Caimi, G | 1 |
| Schoenfeld, N | 5 |
| Epstein, O | 3 |
| Atsmon, A | 9 |
| Doss, M | 2 |
| Moore, MR | 2 |
| McColl, KE | 1 |
| Goldberg, A | 2 |
| Menawat, AS | 1 |
| Panwar, RB | 1 |
| Kochar, DK | 1 |
| Joshi, CK | 1 |
| Brezis, M | 1 |
| Ghanem, J | 1 |
| Weiler-Ravell, D | 1 |
| Morris, D | 1 |
| Wetterberg, L | 1 |
| Douer, D | 2 |
| Weinberger, A | 2 |
| Pinkhas, J | 2 |
| Blum, I | 4 |
| Mamet, R | 1 |
| Mevasser, R | 1 |
| Beckh, K | 1 |
| Sieg, I | 1 |
| Stellwaag, M | 1 |
| Blanke, H | 1 |
| Arnold, R | 1 |
| Srugo, I | 1 |
| Said, E | 1 |
| Korman, S | 1 |
| Jaffe, M | 1 |
| Schwarz, D | 1 |
| Mertin, J | 1 |
| Flacks, LM | 1 |
| Bonkowsky, HL | 1 |
| Tschudy, DP | 1 |
| Beattie, AD | 1 |
| Ward, RL | 1 |
| Fischl, J | 1 |
| Schley, G | 2 |
| Bock, KD | 2 |
| Hocevar, V | 2 |
| Merguet, P | 2 |
| Rausch-Stroomann, JG | 2 |
| Schröder, E | 2 |
| Schümann, HJ | 2 |
| Murata, T | 1 |
1 review available for propranolol and Porphyrias
| Article | Year |
|---|---|
The porphyrias.
Topics: 5-Aminolevulinate Synthetase; Chemical Phenomena; Chemistry; Dietary Carbohydrates; Hemin; Humans; P | 1979 |
23 other studies available for propranolol and Porphyrias
| Article | Year |
|---|---|
[Treatment of acute hepatic porphyria].
Topics: Acute Disease; Adolescent; Adult; Combined Modality Therapy; Dietary Carbohydrates; Dietary Proteins | 1984 |
[Acute intermittent porphyria].
Topics: Acute Disease; Chlorpromazine; Diarrhea; Heme; Hemin; Humans; Intestinal Obstruction; Mitochondria, | 1983 |
The effect of beta-adrenergic blocking agents on experimental porphyria induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo and in vitro.
Topics: 5-Aminolevulinate Synthetase; Adrenergic beta-Antagonists; Aminolevulinic Acid; Animals; Chick Embry | 1976 |
[What is certain in the therapy of porphyrias?].
Topics: Acute Disease; Aspirin; Barbiturates; Chloramphenicol; Chronic Disease; Diazepam; Humans; Porphyrias | 1977 |
Propranolol in acute intermittent porphyria.
Topics: Acute Disease; Blood Pressure; Drug Administration Schedule; Heart Rate; Humans; Porphyrias; Propran | 1979 |
Hematin and propranolol in acute intermittent porphyria. Full recovery from quadriplegic coma and respiratory failure.
Topics: Acute Disease; Adolescent; Coma; Heme; Hemin; Humans; Infusions, Parenteral; Male; Porphyrias; Propr | 1979 |
Clinical importance of melatonin.
Topics: Adolescent; Adult; Aged; Amniotic Fluid; Breast Neoplasms; Child; Circadian Rhythm; Female; Humans; | 1979 |
Treatment of acute intermittent porphyria with large doses of propranolol.
Topics: Administration, Oral; Adult; Female; Humans; Hypertension; Injections, Intravenous; Neurologic Manif | 1978 |
Favourable effect of intravenous propranolol in acute intermittent porphyria.
Topics: Acute Disease; Adult; Humans; Male; Pedigree; Porphyria, Acute Intermittent; Porphyrias; Propranolol | 1978 |
[Mechanism of action of beta-blocking agents in porphyria].
Topics: Animals; Chick Embryo; Liver; Porphyrias; Propranolol; Rats | 1977 |
Reduction of porphyrin excretion in porphyria variegata by propranolol. A case report.
Topics: Adult; Depression, Chemical; Female; Humans; Porphyrias; Porphyrins; Propranolol | 1976 |
Experimental latent and acute porphyria in the non-fasted rat; preventive effect of propranolol.
Topics: Acute Disease; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Coproporphyrins; Dicarbethoxyd | 1991 |
[The coincidence of acute intermittent porphyria and Crohn's disease].
Topics: Acute Disease; Adult; Arginine; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combination; G | 1990 |
Acute intermittent porphyria--an unusual cause of "surgical" abdomen. Response to propranolol therapy.
Topics: Abdomen, Acute; Adolescent; Humans; Liver Diseases; Male; Porphyrias; Propranolol | 1987 |
[Use of propranolol in acute intermittent porphyria].
Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Central Nervous System; Female; Humans; Porphyria | 1973 |
Treatment of acute prophyria variegata with propranolol.
Topics: Acute Disease; Adult; Female; Humans; Porphyrias; Propranolol | 1970 |
Propranolol in acute porphyria.
Topics: Acute Disease; Adolescent; Female; Humans; Porphyrias; Propranolol; Tachycardia | 1970 |
Letter: Hazard of propranolol in treatment of acute prophyria.
Topics: Adult; Bradycardia; Female; Homeostasis; Humans; Hypotension; Porphyrias; Propranolol | 1974 |
Acute intermittent porphyria: response of tachycardia and hypertension to propranolol.
Topics: 5-Aminolevulinate Synthetase; Abdomen, Acute; Adolescent; Adult; Antihypertensive Agents; Blood Pres | 1973 |
The effect of DL-propranolol on delta-aminolevulinic acid synthetase activity and urinary excretion of porphyrins in allylisopropylacetamide-induced experimental porphyria.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chromatography, Ion Exchange; Enzyme | 1973 |
Treatment of an acute attack of porphyria variegata with propranolol.
Topics: Abdomen, Acute; Acute Disease; Adult; Feces; Female; Follow-Up Studies; Humans; Mental Disorders; Ne | 1972 |
[Hypertension and tachycardia in acute intermittent porphyria].
Topics: Adult; Aldosterone; Amino Acids; Anemia; Blood Pressure; Catecholamines; Depression, Chemical; Elect | 1970 |
[On pathogenesis of hypertension and tachycardia in acute thallium poisoning and in acute intermittent porphyria].
Topics: Adult; Female; Humans; Hypertension; Levulinic Acids; Male; Phentolamine; Poisoning; Porphyrias; Pro | 1968 |