propranolol has been researched along with Neuroblastoma in 15 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nude mice bearing BE(2) C neuroblastoma xenografts were injected intraperitoneally with propranolol and divided into groups of PROP-2 (n=11), -5 (n=11), and -10 (n=10) according to the treating dosages of 2, 5, and 10 mg kg(-1) day(-1), respectively." | 7.79 | Antiangiogenic effect of propranolol on the growth of the neuroblastoma xenografts in nude mice. ( Ji, Y; Xiao, X; Xu, T; Yang, S; Zheng, J; Zheng, S; Zhu, H, 2013) |
| " We studied the effects of three beta-adrenoceptor blockers propranolol (1-(isoproplyamino)-3-(naphthalene-1-yloxy)propan-2-ol), atenolol (2-[4-[2-hydroxy-3-(1-methylethylamino)propoxyl]phenyl]ehanamide), and ICI 118551 (1-[2,3-(dihydro-7-methyl-1H-iden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol), against staurosporine-induced apoptosis in SH-SY5Y human neuroblastoma cells." | 7.74 | beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. ( Goubaeva, F; Lee, HT; Mikami, M; Song, JH; Yang, J, 2008) |
| "The action of the (-)- and (+)-enantiomers of the beta-adrenoceptor blocking drug propranolol on the inward calcium current (ICa) was studied in single mouse neuroblastoma x rat glioma hybrid cells of clone 108CC5 by suction pipette technique for intracellular perfusion and voltage clamp." | 7.67 | [Calcium current effects in the presence and absence of propranolol on cloned neuroblastoma and glioma hybrid cells]. ( Bodewei, R; Fischer, W; Hering, S; Wollenberger, A, 1988) |
| " We studied the effects of three beta-adrenoceptor blockers propranolol (1-(isoproplyamino)-3-(naphthalene-1-yloxy)propan-2-ol), atenolol (2-[4-[2-hydroxy-3-(1-methylethylamino)propoxyl]phenyl]ehanamide), and ICI 118551 (1-[2,3-(dihydro-7-methyl-1H-iden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol), against staurosporine-induced apoptosis in SH-SY5Y human neuroblastoma cells." | 3.74 | beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. ( Goubaeva, F; Lee, HT; Mikami, M; Song, JH; Yang, J, 2008) |
| "The action of the (-)- and (+)-enantiomers of the beta-adrenoceptor blocking drug propranolol on the inward calcium current (ICa) was studied in single mouse neuroblastoma x rat glioma hybrid cells of clone 108CC5 by suction pipette technique for intracellular perfusion and voltage clamp." | 3.67 | [Calcium current effects in the presence and absence of propranolol on cloned neuroblastoma and glioma hybrid cells]. ( Bodewei, R; Fischer, W; Hering, S; Wollenberger, A, 1988) |
| " Therefore, the veratridine- (or aconitine-)stimulated influx of [14C]guanidinium in neuroblastoma x glioma hybrid cells was measured to characterize the Na+ ionophore of these cells." | 3.66 | Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines. ( Günther, A; Hamprecht, B; Reiser, G, 1983) |
| "1) activity was stimulated by low concentrations of dopamine and apomorphine, but not by low concentrations of norepinephrine in homogenates of malignant mouse neuroblastoma cells." | 3.65 | Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells. ( Gilmer, KN; Prasad, KN, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yee, EM | 1 |
| Pasquier, E | 1 |
| Iskander, G | 1 |
| Wood, K | 1 |
| Black, DS | 1 |
| Kumar, N | 1 |
| Amar, M | 1 |
| Mallick, BN | 1 |
| Xu, T | 1 |
| Xiao, X | 1 |
| Zheng, S | 1 |
| Zheng, J | 1 |
| Zhu, H | 1 |
| Ji, Y | 1 |
| Yang, S | 1 |
| Wolter, JK | 1 |
| Wolter, NE | 1 |
| Blanch, A | 1 |
| Partridge, T | 1 |
| Cheng, L | 1 |
| Morgenstern, DA | 1 |
| Podkowa, M | 1 |
| Kaplan, DR | 1 |
| Irwin, MS | 1 |
| Mikami, M | 1 |
| Goubaeva, F | 1 |
| Song, JH | 1 |
| Lee, HT | 1 |
| Yang, J | 1 |
| Alavian, KN | 1 |
| Dworetzky, SI | 1 |
| Bonanni, L | 1 |
| Zhang, P | 1 |
| Sacchetti, S | 1 |
| Mariggio, MA | 1 |
| Onofrj, M | 1 |
| Thomas, A | 1 |
| Li, H | 1 |
| Mangold, JE | 1 |
| Signore, AP | 1 |
| Demarco, U | 1 |
| Demady, DR | 1 |
| Nabili, P | 1 |
| Lazrove, E | 1 |
| Smith, PJ | 1 |
| Gribkoff, VK | 1 |
| Jonas, EA | 1 |
| Reiser, G | 2 |
| Günther, A | 1 |
| Hamprecht, B | 3 |
| Singh, IN | 2 |
| McCartney, DG | 1 |
| Kanfer, JN | 2 |
| Adie, EJ | 1 |
| Milligan, G | 1 |
| Sorrentino, G | 1 |
| Massarelli, R | 1 |
| Traber, J | 2 |
| Fischer, K | 2 |
| Bodewei, R | 1 |
| Fischer, W | 1 |
| Hering, S | 1 |
| Wollenberger, A | 1 |
| Gilman, AG | 1 |
| Minna, JD | 1 |
| Prasad, KN | 1 |
| Gilmer, KN | 1 |
| Latzin, S | 1 |
15 other studies available for propranolol and Neuroblastoma
| Article | Year |
|---|---|
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell | 2013 |
Mechanism of noradrenaline-induced α1-adrenoceptor mediated regulation of Na-K ATPase subunit expression in Neuro-2a cells.
Topics: Adrenergic Agents; Adrenergic alpha-1 Receptor Antagonists; Animals; Calcium; Cell Line, Tumor; Cell | 2018 |
Antiangiogenic effect of propranolol on the growth of the neuroblastoma xenografts in nude mice.
Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Blotting, Western; Dose-Response Relationship, | 2013 |
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Autonomic Nervous System Diseases; Cell Growth Proc | 2014 |
beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells.
Topics: Adrenergic beta-Antagonists; Apoptosis; Atenolol; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Lin | 2008 |
Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Biophysical Phen | 2012 |
Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines.
Topics: Animals; Atropine; Calcium; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; Ki | 1983 |
Amyloid beta protein (25-35) stimulation of phospholipases A, C and D activities of LA-N-2 cells.
Topics: Amyloid beta-Peptides; Bombesin; Cell Line; Enzyme Activation; Humans; Inositol; Inositol Phosphates | 1995 |
Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Cloning, Molecular; Enzyme Activation; Glioma; GTP-B | 1994 |
Stimulation of phospholipase C activity by norepinephrine, t-ACPD and bombesin in LA-N-2 cells.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine; Bombesin; Cycloleucine; Excitatory A | 1996 |
Measurements of adenosine 3':5'-cyclic monophosphate and membrane potential in neuroblastoma times glioma hybrid cells: opiates and adrenergic agonists cause effects opposite to those of prostaglandin E1.
Topics: Animals; Cell Line; Clone Cells; Cyclic AMP; Dopamine; Glioma; Haloperidol; Hybrid Cells; Isoprotere | 1975 |
[Calcium current effects in the presence and absence of propranolol on cloned neuroblastoma and glioma hybrid cells].
Topics: Alprenolol; Animals; Calcium Channels; Cells, Cultured; Clone Cells; Glioma; Hybrid Cells; Mice; Neu | 1988 |
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. I. Responses to catecholamines in parental and hybrid cells.
Topics: Adenocarcinoma; Animals; Cell Line; Chromosomes; Clone Cells; Cyclic AMP; Electrophoresis, Starch Ge | 1973 |
Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Catecholamines; Cell Line; Cyclic AMP; Dopamine; Haloperido | 1974 |
Morphine antagonizes the action of prostaglandin in neuroblastoma cells but not of prostaglandin and noradrenaline in glioma and glioma times fibroblast hybrid cells.
Topics: Animals; Cell Fusion; Cell Line; Clone Cells; Cyclic AMP; Fibroblasts; Glioma; Hybrid Cells; Kinetic | 1974 |