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propranolol and Neuroblastoma

propranolol has been researched along with Neuroblastoma in 15 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"Nude mice bearing BE(2) C neuroblastoma xenografts were injected intraperitoneally with propranolol and divided into groups of PROP-2 (n=11), -5 (n=11), and -10 (n=10) according to the treating dosages of 2, 5, and 10 mg kg(-1) day(-1), respectively."7.79Antiangiogenic effect of propranolol on the growth of the neuroblastoma xenografts in nude mice. ( Ji, Y; Xiao, X; Xu, T; Yang, S; Zheng, J; Zheng, S; Zhu, H, 2013)
" We studied the effects of three beta-adrenoceptor blockers propranolol (1-(isoproplyamino)-3-(naphthalene-1-yloxy)propan-2-ol), atenolol (2-[4-[2-hydroxy-3-(1-methylethylamino)propoxyl]phenyl]ehanamide), and ICI 118551 (1-[2,3-(dihydro-7-methyl-1H-iden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol), against staurosporine-induced apoptosis in SH-SY5Y human neuroblastoma cells."7.74beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. ( Goubaeva, F; Lee, HT; Mikami, M; Song, JH; Yang, J, 2008)
"The action of the (-)- and (+)-enantiomers of the beta-adrenoceptor blocking drug propranolol on the inward calcium current (ICa) was studied in single mouse neuroblastoma x rat glioma hybrid cells of clone 108CC5 by suction pipette technique for intracellular perfusion and voltage clamp."7.67[Calcium current effects in the presence and absence of propranolol on cloned neuroblastoma and glioma hybrid cells]. ( Bodewei, R; Fischer, W; Hering, S; Wollenberger, A, 1988)
" We studied the effects of three beta-adrenoceptor blockers propranolol (1-(isoproplyamino)-3-(naphthalene-1-yloxy)propan-2-ol), atenolol (2-[4-[2-hydroxy-3-(1-methylethylamino)propoxyl]phenyl]ehanamide), and ICI 118551 (1-[2,3-(dihydro-7-methyl-1H-iden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol), against staurosporine-induced apoptosis in SH-SY5Y human neuroblastoma cells."3.74beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. ( Goubaeva, F; Lee, HT; Mikami, M; Song, JH; Yang, J, 2008)
"The action of the (-)- and (+)-enantiomers of the beta-adrenoceptor blocking drug propranolol on the inward calcium current (ICa) was studied in single mouse neuroblastoma x rat glioma hybrid cells of clone 108CC5 by suction pipette technique for intracellular perfusion and voltage clamp."3.67[Calcium current effects in the presence and absence of propranolol on cloned neuroblastoma and glioma hybrid cells]. ( Bodewei, R; Fischer, W; Hering, S; Wollenberger, A, 1988)
" Therefore, the veratridine- (or aconitine-)stimulated influx of [14C]guanidinium in neuroblastoma x glioma hybrid cells was measured to characterize the Na+ ionophore of these cells."3.66Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines. ( Günther, A; Hamprecht, B; Reiser, G, 1983)
"1) activity was stimulated by low concentrations of dopamine and apomorphine, but not by low concentrations of norepinephrine in homogenates of malignant mouse neuroblastoma cells."3.65Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells. ( Gilmer, KN; Prasad, KN, 1974)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19906 (40.00)18.7374
1990's3 (20.00)18.2507
2000's1 (6.67)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yee, EM1
Pasquier, E1
Iskander, G1
Wood, K1
Black, DS1
Kumar, N1
Amar, M1
Mallick, BN1
Xu, T1
Xiao, X1
Zheng, S1
Zheng, J1
Zhu, H1
Ji, Y1
Yang, S1
Wolter, JK1
Wolter, NE1
Blanch, A1
Partridge, T1
Cheng, L1
Morgenstern, DA1
Podkowa, M1
Kaplan, DR1
Irwin, MS1
Mikami, M1
Goubaeva, F1
Song, JH1
Lee, HT1
Yang, J1
Alavian, KN1
Dworetzky, SI1
Bonanni, L1
Zhang, P1
Sacchetti, S1
Mariggio, MA1
Onofrj, M1
Thomas, A1
Li, H1
Mangold, JE1
Signore, AP1
Demarco, U1
Demady, DR1
Nabili, P1
Lazrove, E1
Smith, PJ1
Gribkoff, VK1
Jonas, EA1
Reiser, G2
Günther, A1
Hamprecht, B3
Singh, IN2
McCartney, DG1
Kanfer, JN2
Adie, EJ1
Milligan, G1
Sorrentino, G1
Massarelli, R1
Traber, J2
Fischer, K2
Bodewei, R1
Fischer, W1
Hering, S1
Wollenberger, A1
Gilman, AG1
Minna, JD1
Prasad, KN1
Gilmer, KN1
Latzin, S1

Other Studies

15 other studies available for propranolol and Neuroblastoma

ArticleYear
Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents.
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell

2013
Mechanism of noradrenaline-induced α1-adrenoceptor mediated regulation of Na-K ATPase subunit expression in Neuro-2a cells.
    Brain research bulletin, 2018, Volume: 139

    Topics: Adrenergic Agents; Adrenergic alpha-1 Receptor Antagonists; Animals; Calcium; Cell Line, Tumor; Cell

2018
Antiangiogenic effect of propranolol on the growth of the neuroblastoma xenografts in nude mice.
    Journal of pediatric surgery, 2013, Volume: 48, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Biomarkers, Tumor; Blotting, Western; Dose-Response Relationship,

2013
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma.
    Oncotarget, 2014, Jan-15, Volume: 5, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Autonomic Nervous System Diseases; Cell Growth Proc

2014
beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Adrenergic beta-Antagonists; Apoptosis; Atenolol; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Lin

2008
Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency.
    Brain research, 2012, Mar-29, Volume: 1446

    Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Biophysical Phen

2012
Blockade by neurotransmitter antagonists of veratridine-activated ion channels in neuronal cell lines.
    Journal of neurochemistry, 1983, Volume: 40, Issue:2

    Topics: Animals; Atropine; Calcium; Cell Line; Glioma; Guanidine; Guanidines; Hybrid Cells; Ion Channels; Ki

1983
Amyloid beta protein (25-35) stimulation of phospholipases A, C and D activities of LA-N-2 cells.
    FEBS letters, 1995, May-29, Volume: 365, Issue:2-3

    Topics: Amyloid beta-Peptides; Bombesin; Cell Line; Enzyme Activation; Humans; Inositol; Inositol Phosphates

1995
Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade.
    The Biochemical journal, 1994, Nov-01, Volume: 303 ( Pt 3)

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Cloning, Molecular; Enzyme Activation; Glioma; GTP-B

1994
Stimulation of phospholipase C activity by norepinephrine, t-ACPD and bombesin in LA-N-2 cells.
    European journal of pharmacology, 1996, Jul-11, Volume: 308, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine; Bombesin; Cycloleucine; Excitatory A

1996
Measurements of adenosine 3':5'-cyclic monophosphate and membrane potential in neuroblastoma times glioma hybrid cells: opiates and adrenergic agonists cause effects opposite to those of prostaglandin E1.
    FEBS letters, 1975, Apr-01, Volume: 52, Issue:2

    Topics: Animals; Cell Line; Clone Cells; Cyclic AMP; Dopamine; Glioma; Haloperidol; Hybrid Cells; Isoprotere

1975
[Calcium current effects in the presence and absence of propranolol on cloned neuroblastoma and glioma hybrid cells].
    Biomedica biochimica acta, 1988, Volume: 47, Issue:3

    Topics: Alprenolol; Animals; Calcium Channels; Cells, Cultured; Clone Cells; Glioma; Hybrid Cells; Mice; Neu

1988
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. I. Responses to catecholamines in parental and hybrid cells.
    The Journal of biological chemistry, 1973, Oct-10, Volume: 248, Issue:19

    Topics: Adenocarcinoma; Animals; Cell Line; Chromosomes; Clone Cells; Cyclic AMP; Electrophoresis, Starch Ge

1973
Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:6

    Topics: Adenylyl Cyclases; Animals; Apomorphine; Catecholamines; Cell Line; Cyclic AMP; Dopamine; Haloperido

1974
Morphine antagonizes the action of prostaglandin in neuroblastoma cells but not of prostaglandin and noradrenaline in glioma and glioma times fibroblast hybrid cells.
    FEBS letters, 1974, Dec-15, Volume: 49, Issue:2

    Topics: Animals; Cell Fusion; Cell Line; Clone Cells; Cyclic AMP; Fibroblasts; Glioma; Hybrid Cells; Kinetic

1974