Page last updated: 2024-11-03

propranolol and Neoplasm Metastasis

propranolol has been researched along with Neoplasm Metastasis in 20 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Research Excerpts

ExcerptRelevanceReference
" In this study, we investigated the effect of propranolol, a non-selective beta-blocker on overall survival (OS) in unresectable/metastatic hepatocellular carcinoma (HCC) and on recurrence-free survival (RFS) in resectable, curable HCC."7.91The effect of propranolol on the prognosis of hepatocellular carcinoma: A nationwide population-based study. ( Chang, PY; Chang, WC; Chien, WC; Chung, CH; Dai, MS; Ho, CL; Lin, CS; Lin, HH, 2019)
" In this study, we investigated the effect of propranolol, a non-selective beta-blocker on overall survival (OS) in unresectable/metastatic hepatocellular carcinoma (HCC) and on recurrence-free survival (RFS) in resectable, curable HCC."3.91The effect of propranolol on the prognosis of hepatocellular carcinoma: A nationwide population-based study. ( Chang, PY; Chang, WC; Chien, WC; Chung, CH; Dai, MS; Ho, CL; Lin, CS; Lin, HH, 2019)
"Different pharmacologic drugs (isadrin, obsidan, phentolamine) changing adrenergic processes are shown to have different effect on the growth and development of lung metastases."3.67[Changes in the metastasis of experimental tumors and in the antimetastatic effect of cytostatics in their pharmacological action on adrenergic processes]. ( Balitskiĭ, KP; Riabukha, VN; Smelkova, MI; Veksler, IG, 1984)
"However, β -adrenergic action in breast cancer is controversial."1.46The β 2-Adrenergic Agonist Salbutamol Inhibits Migration, Invasion and Metastasis of the Human Breast Cancer MDA-MB- 231 Cell Line. ( Bruzzone, A; Entschladen, F; Gargiulo, L; Lüthy, IA; Piñero, CP; Rivero, EM; Zänker, K, 2017)
"Propranolol treatment delayed primary tumor growth and metastases development in MT/Ret mice."1.43Propranolol induces a favourable shift of anti-tumor immunity in a murine spontaneous model of melanoma. ( Bod, L; Jean Wrobel, L; Kato, M; Le Gal, FA; Lengagne, R; Prévost-Blondel, A, 2016)
"Furthermore, we report that breast cancer cell migration is decreased by the FDA-approved β-blocker, propranolol."1.42β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells. ( Lorimer, E; Tyburski, MD; Williams, CL; Wilson, JM, 2015)
"When tumors reached 100 mm, mice were treated with CpG-C/vehicle, and 24 hours later the tumor was excised along with P+E/vehicle treatment."1.37Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses. ( Ben-Eliyahu, S; Benish, M; Goldfarb, Y; Levi, B; Melamed, R; Sorski, L, 2011)
"Propranolol users were significantly less likely to present with a T4 (odds ratio [OR], 0."1.37Beta blockers and breast cancer mortality: a population- based study. ( Barron, TI; Bennett, K; Connolly, RM; Sharp, L; Visvanathan, K, 2011)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19908 (40.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rivero, EM1
Piñero, CP1
Gargiulo, L1
Entschladen, F2
Zänker, K1
Bruzzone, A1
Lüthy, IA1
Chang, PY1
Chung, CH1
Chang, WC1
Lin, CS1
Lin, HH1
Dai, MS1
Ho, CL1
Chien, WC1
Barbieri, A1
Bimonte, S1
Palma, G1
Luciano, A1
Rea, D1
Giudice, A1
Scognamiglio, G1
La Mantia, E1
Franco, R1
Perdonà, S1
De Cobelli, O1
Ferro, M1
Zappavigna, S1
Stiuso, P1
Caraglia, M1
Arra, C1
Wilson, JM1
Lorimer, E1
Tyburski, MD1
Williams, CL1
Duff, S1
Connolly, C1
Buggy, DJ1
Jean Wrobel, L1
Bod, L1
Lengagne, R1
Kato, M1
Prévost-Blondel, A1
Le Gal, FA1
Glasner, A1
Avraham, R1
Rosenne, E1
Benish, M2
Zmora, O1
Shemer, S1
Meiboom, H1
Ben-Eliyahu, S2
Schuller, HM1
Goldfarb, Y1
Sorski, L1
Levi, B1
Melamed, R1
Ganz, PA1
Cole, SW1
Barron, TI1
Connolly, RM1
Sharp, L1
Bennett, K1
Visvanathan, K1
Strell, C1
Niggemann, B1
Voss, MJ1
Powe, DG1
Zänker, KS1
Balitskiĭ, KP2
Veksler, IG1
Riabukha, VN1
Smelkova, MI1
Shaklai, M1
Aderka, D1
Blum, I1
Laron, Z1
Asherov, J1
Doron, M1
Atsmon, A1
Pinkhas, J1
van den Broek, PJ1
de Graeff, J1
Wade, H1
Scharf, Y1
Nahir, AM1
Better, OS1
Koten, A1
Arieh, YB1
Gellei, B1
Harrison, TS1
Freier, DT1
Cohen, EL1
Storstein, O1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Improving Perioperative Pain Management for Laparoscopic Surgery Due to Colon Cancer Using the Ultrasound-guided Transmuscular Quadratus Lumborum Block. A Double Blind, Randomized, Placebo Controlled Trial.[NCT03570541]Phase 469 participants (Actual)Interventional2018-06-28Completed
Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery[NCT03974984]0 participants (Actual)Observational2020-06-04Withdrawn (stopped due to Not feasable due to logistics)
Impact of Novel Thoracic Wall Blocks With Dexmetomidine on Inflammatory Markers Following Breast Cancer Surgery[NCT04860115]120 participants (Anticipated)Interventional2021-11-01Not yet recruiting
Melablock: A Multicentre Randomized, Double---blinded and Placebo---controlled Clinical Trial on the Efficacy and Safety of Once Daily Propranolol 80 mg Retard for the Prevention of Cutaneous Malignant Melanoma Recurrence[NCT02962947]Phase 2/Phase 3546 participants (Anticipated)Interventional2017-06-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for propranolol and Neoplasm Metastasis

ArticleYear
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
    International anesthesiology clinics, 2016,Fall, Volume: 54, Issue:4

    Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr

2016

Other Studies

19 other studies available for propranolol and Neoplasm Metastasis

ArticleYear
The β 2-Adrenergic Agonist Salbutamol Inhibits Migration, Invasion and Metastasis of the Human Breast Cancer MDA-MB- 231 Cell Line.
    Current cancer drug targets, 2017, Volume: 17, Issue:8

    Topics: Adrenergic Agonists; Albuterol; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Pro

2017
The effect of propranolol on the prognosis of hepatocellular carcinoma: A nationwide population-based study.
    PloS one, 2019, Volume: 14, Issue:5

    Topics: Adult; Aged; Carcinoma, Hepatocellular; Disease-Free Survival; Female; Humans; Liver Neoplasms; Male

2019
The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo.
    International journal of oncology, 2015, Volume: 47, Issue:2

    Topics: Animals; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Gene Expression Regulati

2015
β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
    Cancer biology & therapy, 2015, Volume: 16, Issue:9

    Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Aminopyridines; Breast Neoplasms;

2015
Propranolol induces a favourable shift of anti-tumor immunity in a murine spontaneous model of melanoma.
    Oncotarget, 2016, Nov-22, Volume: 7, Issue:47

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Lymphocytes, Tumor-Infiltrating; Melanoma, Exper

2016
Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Mar-01, Volume: 184, Issue:5

    Topics: Adrenergic beta-Antagonists; Amputation, Surgical; Animals; Antineoplastic Combined Chemotherapy Pro

2010
Beta-adrenergic signaling, a novel target for cancer therapy?
    Oncotarget, 2010, Volume: 1, Issue:7

    Topics: Adrenergic beta-Antagonists; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Female; Humans; Hyp

2010
Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses.
    Annals of surgery, 2011, Volume: 253, Issue:4

    Topics: Analysis of Variance; Animals; Chemotherapy, Adjuvant; Disease Models, Animal; Etodolac; Female; Imm

2011
Expanding our therapeutic options: Beta blockers for breast cancer?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jul-01, Volume: 29, Issue:19

    Topics: Adrenergic beta-Antagonists; Atenolol; Breast Neoplasms; Diabetes Complications; Disease-Free Surviv

2011
Beta blockers and breast cancer mortality: a population- based study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jul-01, Volume: 29, Issue:19

    Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Breast Neoplasms; Disease Progression; Female; Humans;

2011
Norepinephrine promotes the β1-integrin-mediated adhesion of MDA-MB-231 cells to vascular endothelium by the induction of a GROα release.
    Molecular cancer research : MCR, 2012, Volume: 10, Issue:2

    Topics: Adrenergic beta-Antagonists; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Chemokine CXCL1; End

2012
[Methods of directly influencing the metastatic process].
    Voprosy onkologii, 1984, Volume: 30, Issue:10

    Topics: Animals; Growth Inhibitors; Interferons; Isoproterenol; Macrophages; Mice; Mice, Inbred Strains; Neo

1984
[Changes in the metastasis of experimental tumors and in the antimetastatic effect of cytostatics in their pharmacological action on adrenergic processes].
    Eksperimental'naia onkologiia, 1984, Volume: 6, Issue:6

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Evaluation, Preclinical; Drug Therapy, Combin

1984
Suppression of hypoglycemic attacks and insulin release by propranolol in a patient with metastatic malignant insulinoma.
    Diabete & metabolisme, 1977, Volume: 3, Issue:3

    Topics: Adenoma, Islet Cell; Female; Humans; Hypoglycemia; Insulin; Insulin Secretion; Middle Aged; Neoplasm

1977
Prolonged survival in a patient with pulmonary metastases of a malignant pheochromocytoma.
    The Netherlands journal of medicine, 1978, Volume: 21, Issue:6

    Topics: Adrenal Gland Neoplasms; Adult; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Middle Ag

1978
The surgical management of thyroid disorders.
    Transactions of the Medical Society of London, 1972, Volume: 88

    Topics: Adenocarcinoma; Age Factors; Calcitonin; Carbimazole; Goiter; Humans; Hyperthyroidism; Neoplasm Meta

1972
Prolonged survival in malignant pheochromocytoma of the organ of Zuckerkandl with pharmacological treatment.
    Cancer, 1973, Volume: 31, Issue:3

    Topics: Adrenal Gland Neoplasms; Adult; Chromaffin System; Cyclophosphamide; Female; Follow-Up Studies; Huma

1973
Proceedings: Recurrent pheochromocytoma.
    Archives of surgery (Chicago, Ill. : 1960), 1974, Volume: 108, Issue:4

    Topics: Abdominal Neoplasms; Adolescent; Adrenal Gland Neoplasms; Adult; Child; Epinephrine; Female; Hormone

1974
Hemodynamic studies in primary myocardial disease.
    Acta medica Scandinavica. Supplementum, 1967, Volume: 472

    Topics: Adolescent; Adult; Amyloidosis; Angiography; Aortic Valve Stenosis; Beriberi; Blood Pressure; Carcin

1967