propranolol has been researched along with Morphine Dependence in 19 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine withdrawal was precipitated on day 8 by the injection of naloxone (2 mg/kg s." | 1.38 | Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase. ( Almela, P; Hurle, MA; Laorden, ML; Martínez-Laorden, E; Milanés, MV, 2012) |
| "morphine was suppressed by combined injection of adrenergic blockers, 10 mg/kg i." | 1.28 | Development of physical dependence on morphine not accompanied with tolerance formation. ( Kaneto, H; Ohta, A, 1992) |
| "When propranolol and morphine were administered concurrently the morphine ED50 (on day 5) was twice that of the group receiving morphine alone." | 1.25 | Effect of propranolol on antinociceptive, tolerance- and dependence-producing properties of morphine in rodents and monkeys. ( Cowan, A; Macfarlane, IR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (47.37) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, Y | 1 |
| Li, Y | 1 |
| Yang, X | 1 |
| Sui, N | 1 |
| Martínez-Laorden, E | 1 |
| Hurle, MA | 1 |
| Milanés, MV | 1 |
| Laorden, ML | 1 |
| Almela, P | 1 |
| Nakagawa, T | 1 |
| Nagayasu, K | 1 |
| Nishitani, N | 1 |
| Shirakawa, H | 1 |
| Sekiguchi, K | 1 |
| Ikarashi, Y | 1 |
| Kase, Y | 1 |
| Kaneko, S | 1 |
| Zarrindast, MR | 3 |
| Assadi, E | 1 |
| Oryan, S | 1 |
| Torkaman-Boutorabi, A | 1 |
| Sahebgharani, M | 1 |
| Samanin, R | 1 |
| Cervo, L | 1 |
| Rochat, C | 1 |
| Poggesi, E | 1 |
| Mennini, T | 1 |
| Harris, GC | 1 |
| Aston-Jones, G | 2 |
| Russell, JA | 1 |
| Coombes, JE | 1 |
| Leng, G | 1 |
| Bicknell, RJ | 1 |
| Farzin, D | 1 |
| Rezayat, M | 1 |
| Azizi, N | 1 |
| Delfs, JM | 1 |
| Druhan, J | 1 |
| Zhu, Y | 1 |
| Cowan, A | 1 |
| Macfarlane, IR | 1 |
| Berkowitz, BA | 1 |
| Charalampous, KD | 1 |
| Askew, WE | 1 |
| Drawbaugh, RB | 1 |
| Lal, H | 1 |
| Jacob, RG | 1 |
| Holmstrand, J | 1 |
| Eriksson, JH | 1 |
| Anggård, E | 1 |
| Ohta, A | 1 |
| Kaneto, H | 1 |
| Jhamandas, K | 1 |
| Sutak, M | 1 |
| Bell, S | 1 |
| Cicero, TJ | 1 |
| Meyer, ER | 1 |
| Bell, RD | 1 |
| Martin, WR | 1 |
| Eades, CG | 1 |
| Thompson, WO | 1 |
| Thompson, JA | 1 |
| Flanary, HG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation[NCT05351333] | 66 participants (Anticipated) | Interventional | 2022-08-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propranolol and Morphine Dependence
| Article | Year |
|---|---|
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Fem | 1976 |
1 trial available for propranolol and Morphine Dependence
| Article | Year |
|---|---|
Propranolol in the treatment of opiate dependence -- a controlled study.
Topics: Adolescent; Adult; Clinical Trials as Topic; Euphoria; Female; Heart Rate; Humans; Male; Methadone; | 1975 |
17 other studies available for propranolol and Morphine Dependence
| Article | Year |
|---|---|
Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amygdala; Analysis of Variance; Animals; | 2014 |
Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase.
Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Aminoacetonitrile; Animals; Catechol O-Met | 2012 |
Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptor.
Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; | 2012 |
Influence of histamine, cimetidine and pyrilamine on naloxone-induced jumping in morphine-dependent mice.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 2003 |
Reduction in the number of serotonin receptors in the brainstem of morphine dependent rats: relation to blockade of naloxone precipitated jumping by serotonin agonists.
Topics: Animals; Behavior, Animal; Brain Stem; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Na | 1980 |
Beta-adrenergic antagonists attenuate withdrawal anxiety in cocaine- and morphine-dependent rats.
Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Atenolol; Cocaine; Injections, Intraperitoneal; Male; | 1993 |
Morphine tolerance and inhibition of oxytocin secretion by kappa-opioids acting on the rat neurohypophysis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1993 |
Nicotine attenuates naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: Animals; Atropine; Behavior, Animal; Benzazepines; Hexamethonium; Male; Mecamylamine; Mice; Morphine | 1996 |
On the mechanism(s) of cholecystokinin (CCK): receptor stimulation attenuates morphine dependence in mice.
Topics: Adrenergic Antagonists; Animals; Atropine; Benzazepines; Ceruletide; Dopamine Antagonists; Male; Met | 1997 |
The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal.
Topics: Amygdala; Animals; Axonal Transport; Caudate Nucleus; Male; Microinjections; Morphine Dependence; Na | 1999 |
Effect of propranolol on antinociceptive, tolerance- and dependence-producing properties of morphine in rodents and monkeys.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Female; Haplorhini; Humans; Macaca m | 1975 |
Cerebellar cAMP levels following acute and chronic morphine administration.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cerebellum; Cyclic AMP; Humans; Male; Mice; Morphine; | 1977 |
Effect of pharmacological interference with various neuropathways on blockade of morphine-withdrawal hypothermia by morphine and by conditional stimulus.
Topics: Animals; Benztropine; Conditioning, Classical; Cyproheptadine; Haloperidol; Humans; Hypothermia; Mal | 1976 |
Development of physical dependence on morphine not accompanied with tolerance formation.
Topics: Analgesia; Animals; Drug Interactions; Drug Tolerance; Injections, Intraperitoneal; Injections, Subc | 1992 |
Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms.
Topics: Animals; Atropine; Autonomic Nervous System; Diphenhydramine; Dose-Response Relationship, Drug; Drug | 1973 |
Effects of phenoxybenzamine on the narcotic withdrawal syndrome in the rat.
Topics: Adrenergic beta-Antagonists; Animals; Behavior, Animal; Body Weight; Chlorpromazine; Depression, Che | 1974 |
Morphine physical dependence in the dog.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Dogs; Dose-Response Relationship, Drug; Ha | 1974 |