propranolol has been researched along with Long Sleeper Syndrome in 24 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propranolol has been widely used in the treatment of infantile hemangiomas since 2008." | 9.22 | Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas. ( Chang, L; Chen, H; Hu, L; Huang, H; Jin, Y; Li, W; Lin, X; Ma, G; Qiu, Y; Xu, X; Zhou, B, 2016) |
| "Sleep problems are frequently reported in infants treated with propranolol for infantile hemangiomas, possibly serving as a marker for a negative impact on central nervous system function." | 8.02 | Sleep behavior of infants with infantile hemangioma treated with propranolol-a cohort study. ( Gnannt, R; Kernland-Lang, K; Knöpfel, N; Kohler, M; Kurth, S; Luchsinger, I; Neuhaus, K; Schoch, SF; Schwieger-Briel, A; Smith, A; Theiler, M; von der Heydt, S; Waelchli, R; Weibel, L, 2021) |
| "We treated 28 patients (16 women and 12 men) who had essential tremor with methazolamide." | 7.68 | Treatment of essential tremor with methazolamide. ( Caviness, JN; Daube, JR; Miller, PM; Muenter, MD, 1991) |
| "Propranolol appears to be an effective treatment option for IH even in the nonproliferative phase and after the first year of life." | 5.37 | Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants. ( Breugem, CC; Breur, JMPJ; de Graaf, M; Pasmans, SGMA; Raphaël, MF; Vos, M, 2011) |
| "Propranolol has been widely used in the treatment of infantile hemangiomas since 2008." | 5.22 | Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas. ( Chang, L; Chen, H; Hu, L; Huang, H; Jin, Y; Li, W; Lin, X; Ma, G; Qiu, Y; Xu, X; Zhou, B, 2016) |
| "Sleep problems are frequently reported in infants treated with propranolol for infantile hemangiomas, possibly serving as a marker for a negative impact on central nervous system function." | 4.02 | Sleep behavior of infants with infantile hemangioma treated with propranolol-a cohort study. ( Gnannt, R; Kernland-Lang, K; Knöpfel, N; Kohler, M; Kurth, S; Luchsinger, I; Neuhaus, K; Schoch, SF; Schwieger-Briel, A; Smith, A; Theiler, M; von der Heydt, S; Waelchli, R; Weibel, L, 2021) |
| "We treated 28 patients (16 women and 12 men) who had essential tremor with methazolamide." | 3.68 | Treatment of essential tremor with methazolamide. ( Caviness, JN; Daube, JR; Miller, PM; Muenter, MD, 1991) |
| "An elderly, mildly demented, hypertensive male patient developed hypersomnolence on administration of propranolol for treatment of hypertension; no other cause for hypersomnolence was detected." | 3.67 | Hypersomnolence with beta-adrenergic blockers. ( Kochar, MS; Thachil, J; Zeller, JR, 1987) |
| "Propranolol appears to be an effective treatment option for IH even in the nonproliferative phase and after the first year of life." | 1.37 | Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants. ( Breugem, CC; Breur, JMPJ; de Graaf, M; Pasmans, SGMA; Raphaël, MF; Vos, M, 2011) |
| "Cardiomegaly was seen in 9/23 patients with nocturnal angina and 22/141 without (p less than 0." | 1.26 | Significance and treatment of nocturnal angina preceding myocardial infarction. ( Alosilla, C; Chadda, KD; Gupta, PK; Lichstein, E, 1977) |
| "Diarrhoea, impotence, failure of ejaculation, blurred vision, depression, and the symptoms of postural hypotension were not related to methyldopa therapy." | 1.25 | Side effects of hypotensive agents evaluated by a self-administered questionnaire. ( Bulpitt, CJ; Dollery, CT, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (62.50) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Xerfan, EMS | 1 |
| Andersen, ML | 1 |
| Facina, AS | 1 |
| Tufik, S | 1 |
| Tomimori, J | 1 |
| Theiler, M | 1 |
| Knöpfel, N | 1 |
| von der Heydt, S | 1 |
| Schwieger-Briel, A | 1 |
| Luchsinger, I | 1 |
| Smith, A | 1 |
| Kernland-Lang, K | 1 |
| Waelchli, R | 1 |
| Neuhaus, K | 1 |
| Kohler, M | 1 |
| Gnannt, R | 1 |
| Schoch, SF | 1 |
| Weibel, L | 1 |
| Kurth, S | 1 |
| Gumina, ME | 1 |
| Yan, AC | 1 |
| Hu, L | 1 |
| Zhou, B | 1 |
| Huang, H | 1 |
| Chang, L | 1 |
| Qiu, Y | 1 |
| Ma, G | 1 |
| Chen, H | 1 |
| Jin, Y | 1 |
| Xu, X | 1 |
| Lin, X | 1 |
| Li, W | 1 |
| Moyakine, AV | 1 |
| Kerstjens, JM | 1 |
| Spillekom-van Koulil, S | 1 |
| van der Vleuten, CJ | 1 |
| de Graaf, M | 1 |
| Breur, JMPJ | 1 |
| Raphaël, MF | 1 |
| Vos, M | 1 |
| Breugem, CC | 1 |
| Pasmans, SGMA | 1 |
| Kuo, TB | 1 |
| Chen, CY | 1 |
| Lai, CT | 1 |
| Chuan, TY | 1 |
| Wu, WY | 1 |
| Tsai, SC | 1 |
| Yang, CC | 1 |
| Harris, E | 1 |
| Rowe, JW | 1 |
| Troen, BR | 1 |
| Hepner, SI | 1 |
| Davoli, E | 1 |
| Katerndahl, DA | 1 |
| Snisarenko, AA | 1 |
| Sjöholm, TT | 1 |
| Lehtinen, I | 1 |
| Piha, SJ | 1 |
| Lichstein, E | 1 |
| Alosilla, C | 1 |
| Chadda, KD | 1 |
| Gupta, PK | 1 |
| Robert, M | 1 |
| Muenter, MD | 1 |
| Daube, JR | 1 |
| Caviness, JN | 1 |
| Miller, PM | 1 |
| Hauri, PJ | 1 |
| Friedman, M | 1 |
| Ravaris, CL | 1 |
| Koella, WP | 1 |
| Brismar, K | 1 |
| Hylander, B | 1 |
| Eliasson, K | 1 |
| Rössner, S | 1 |
| Wetterberg, L | 1 |
| Thachil, J | 1 |
| Zeller, JR | 1 |
| Kochar, MS | 1 |
| Rackensperger, W | 1 |
| Gaupp, R | 1 |
| Mattke, DJ | 1 |
| Schwarz, D | 1 |
| Stutte, KH | 1 |
| Bulpitt, CJ | 1 |
| Dollery, CT | 1 |
| Wheatley, D | 1 |
| O'Brien, ET | 1 |
| MacKinnon, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Study of Sildenafil for the Treatment of Lymphatic Malformations[NCT02335242] | Phase 2 | 22 participants (Actual) | Interventional | 2015-05-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants will be followed for the duration of the study, an expected average of 20 weeks. (NCT02335242)
Timeframe: Baseline, week 20
| Intervention | percentage of volume (Mean) |
|---|---|
| Double-Blind Placebo | 5.89 |
| Open-Label Sildenafil | -8.54 |
| Double-blind Sildenafil | -0.642 |
"Subject's evaluation of the overall change in lymphatic malformation. Participants will be followed from baseline to 20 weeks.~Patients rated change as no improvement, minimal improvement (1-25% change), fair improvement (25-50% change), good improvement (50-75% change), and excellent improvement (75-100% change)." (NCT02335242)
Timeframe: Baseline, week 20
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| No improvement | Minimal improvement | Fair improvement | Good improvement | Excellent improvement | |
| Double-Blind Placebo | 1 | 2 | 0 | 2 | 0 |
| Double-Blind Sildenafil | 2 | 4 | 1 | 1 | 0 |
3 reviews available for propranolol and Long Sleeper Syndrome
| Article | Year |
|---|---|
Sleep disturbances as an adverse effect of propranolol use in children with infantile hemangioma.
Topics: Adrenergic beta-Antagonists; Hemangioma; Humans; Infant; Propranolol; Sleep Wake Disorders | 2020 |
Sympathetic nervous system and aging in man.
Topics: Adolescent; Adrenal Medulla; Adult; Aged; Aging; Animals; Blood Pressure; Child; Circadian Rhythm; C | 1980 |
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys | 1985 |
5 trials available for propranolol and Long Sleeper Syndrome
| Article | Year |
|---|---|
Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Blood Glucose; Body Height; Body Weight; Child; C | 2016 |
Sleep in patients with spontaneous panic attacks.
Topics: Adolescent; Adult; Alprazolam; Cerebral Cortex; Clinical Trials as Topic; Double-Blind Method; Elect | 1989 |
Melatonin secretion related to side-effects of beta-blockers from the central nervous system.
Topics: Adult; Atenolol; Circadian Rhythm; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertensi | 1988 |
[Treatment of acute schizophrenic psychosis with beta-adrenergic blocking agents (author's transl)].
Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Blood Pressure; Catatonia; Clinical Trials as Top | 1974 |
Comparative effects of propranolol and chlordiazepoxide in anxiety states.
Topics: Anxiety Disorders; Chlordiazepoxide; Clinical Trials as Topic; Depression; Humans; Propranolol; Psyc | 1969 |
16 other studies available for propranolol and Long Sleeper Syndrome
| Article | Year |
|---|---|
Sleep behavior of infants with infantile hemangioma treated with propranolol-a cohort study.
Topics: Adrenergic beta-Antagonists; Cohort Studies; Hemangioma; Humans; Infant; Propranolol; Skin Neoplasms | 2021 |
Atenolol as an alternative to propranolol for the management of sleep disturbances in the treatment of infantile hemangiomas.
Topics: Administration, Oral; Atenolol; Drug Substitution; Female; Hemangioma, Capillary; Humans; Infant; Pa | 2019 |
Propranolol treatment of infantile hemangioma (IH) is not associated with developmental risk or growth impairment at age 4 years.
Topics: Body Height; Body Weight; Case-Control Studies; Child Development; Child, Preschool; Female; Hemangi | 2016 |
Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants.
Topics: Adrenergic beta-Antagonists; Biopsy, Needle; Bronchial Hyperreactivity; Cohort Studies; Dose-Respons | 2011 |
Sleep disturbance among spontaneously hypertensive rats is mediated by an α1-adrenergic mechanism.
Topics: Animals; Atenolol; Blood Pressure; Male; Prazosin; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred | 2012 |
Sedative - hypnotic drugs.
Topics: Anti-Anxiety Agents; Anxiety; Barbiturates; Benzodiazepines; Histamine H1 Antagonists; Humans; Hypno | 1981 |
Successful treatment of supraventricular tachycardia with metoprolol, a cardioselective beta blocker.
Topics: Bronchial Spasm; Digoxin; Drug Therapy, Combination; Female; Humans; Infant; Metoprolol; Propanolami | 1983 |
Panic.
Topics: Adult; Anxiety Disorders; Cardiovascular Diseases; Endocrine System Diseases; Fear; Female; Humans; | 1982 |
[Effect of the beta-adrenoblocker propranolol and the tranquilizer seduxen on natural sleep in cats].
Topics: Animals; Cats; Diazepam; Drug Interactions; Humans; Male; Propranolol; Sleep; Sleep Stages; Sleep Wa | 1981 |
The effect of propranolol on sleep bruxism: hypothetical considerations based on a case study.
Topics: Adrenergic beta-Antagonists; Adult; Bruxism; Electromyography; Female; Humans; Jaw; Masseter Muscle; | 1996 |
Significance and treatment of nocturnal angina preceding myocardial infarction.
Topics: Acute Disease; Angina Pectoris; Cardiomegaly; Digitalis Glycosides; Electrocardiography; Female; Hea | 1977 |
[Intensive care in the elderly patient. Clinical aspects (author's transl)].
Topics: Acute Kidney Injury; Aged; Dyspnea; Female; Humans; Intensive Care Units; Male; Micrognathism; Middl | 1977 |
Treatment of essential tremor with methazolamide.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arm; Female; Head; Humans; Leg; Male; Methazolamide; Mi | 1991 |
Hypersomnolence with beta-adrenergic blockers.
Topics: Aged; Atenolol; Disorders of Excessive Somnolence; Humans; Hypertension; Male; Propranolol; Sleep Wa | 1987 |
Side effects of hypotensive agents evaluated by a self-administered questionnaire.
Topics: Antihypertensive Agents; Defecation; Diuretics; Ejaculation; Erectile Dysfunction; Female; Guanethid | 1973 |
Propranolol and polythiazide in treatment of hypertension.
Topics: Adult; Black or African American; Blood Pressure; Bronchial Spasm; Drug Synergism; Female; Hallucina | 1972 |