propranolol has been researched along with Long QT Syndrome in 86 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We describe two cases where a switch to bisoprolol resulted in worsening of arrhythmia control: A man with LQT2, asymptomatic on propranolol, experienced syncope after switching to bisoprolol 5 mg daily." | 7.83 | Two Cases of LQT Syndrome with Malignant Syncope after Switch from Propranolol to Bisoprolol. ( Jensen, SM; Kesek, M; Rydberg, A, 2016) |
| " This positive lidocaine challenge prompted clinical suspicion of long QT syndrome type 3 (LQT3) and early initiation of mexiletine therapy." | 7.76 | Neonatal long QT syndrome type 3 predicted by positive lidocaine challenge. ( Bailey, A; DI Maria, M; Howley, LW; Schaffer, MS, 2010) |
| "The effects of adrenergic activity and beta-blockade were studied in a canine experimental model of type-3 long QT syndrome (LQT3) induced by application of anthopleurin-A." | 7.74 | Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome. ( Ahara, S; Aizawa, Y; Chinushi, M; Furushima, H; Hosaka, Y; Iijima, K; Izumi, D; Komura, S, 2008) |
| "This study used monophasic action potentials to investigate the effects of verapamil and propranolol on epinephrine-induced repolarization abnormalities in congenital long QT syndrome." | 7.69 | Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome. ( Aihara, N; Arakaki, Y; Kamakura, S; Kamiya, T; Kawade, M; Kurita, T; Ohe, T; Shimizu, W; Shimomura, K, 1995) |
| " In the present study, the effects of intravenous administration of prostacyclin (PGI2) and prostaglandin E2 (PGE2) on early afterdepolarizations and ventricular tachycardia induced by cesium chloride (0." | 7.68 | Prostaglandin modulation of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium chloride combined with efferent cardiac sympathetic stimulation in dogs. ( Miyazaki, T; Pride, HP; Zipes, DP, 1990) |
| " After propranolol iv it was no more possible to induce major ventricular arrhythmias anymore." | 7.67 | [Torsade de pointes during an atropine sulfate test in a patient with congenital long QT syndrome]. ( Beccaria, E; Brun, S; Conti, M; Gaita, F; Giustetto, C, 1989) |
| "Propranolol has a significantly better QTc shortening effect compared to metoprolol and nadolol, especially in patients with prolonged QTc." | 5.38 | Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. ( Ackerman, MJ; Beckmann, BM; Blom, NA; Chockalingam, P; Clur, SA; Crotti, L; Fischer, M; Girardengo, G; Harris, KM; Hauer, RN; Johnson, JN; Kääb, S; Rordorf, R; Rydberg, A; Schwartz, PJ; Spazzolini, C; van den Heuvel, F; van der Heijden, JF; Wilde, AA, 2012) |
| " We describe two cases where a switch to bisoprolol resulted in worsening of arrhythmia control: A man with LQT2, asymptomatic on propranolol, experienced syncope after switching to bisoprolol 5 mg daily." | 3.83 | Two Cases of LQT Syndrome with Malignant Syncope after Switch from Propranolol to Bisoprolol. ( Jensen, SM; Kesek, M; Rydberg, A, 2016) |
| "Beta-adrenergic receptor antagonists (β-blockers) are the therapy of choice for the long QT syndrome but their efficacy is not homogeneous: propranolol and nadolol are the most effective, whereas metoprolol is associated with more treatment failures." | 3.78 | Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome. ( Besana, A; George, AL; Schwartz, PJ; Wang, DW, 2012) |
| " This positive lidocaine challenge prompted clinical suspicion of long QT syndrome type 3 (LQT3) and early initiation of mexiletine therapy." | 3.76 | Neonatal long QT syndrome type 3 predicted by positive lidocaine challenge. ( Bailey, A; DI Maria, M; Howley, LW; Schaffer, MS, 2010) |
| "The effects of adrenergic activity and beta-blockade were studied in a canine experimental model of type-3 long QT syndrome (LQT3) induced by application of anthopleurin-A." | 3.74 | Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome. ( Ahara, S; Aizawa, Y; Chinushi, M; Furushima, H; Hosaka, Y; Iijima, K; Izumi, D; Komura, S, 2008) |
| " Prenatal treatment with beta-adrenergic blocker (propranolol) and digitalis glycosides was prescribed because of suspicion of long QT syndrome occurring with fetal congestive heart failure." | 3.71 | Prenatal diagnosis and treatment of fetal long QT syndrome: a case report. ( Chang, IK; Chow, SN; Hsieh, FJ; Kau, ML; Ko, YH; Lee, CN; Shyu, MK, 2002) |
| "This study used monophasic action potentials to investigate the effects of verapamil and propranolol on epinephrine-induced repolarization abnormalities in congenital long QT syndrome." | 3.69 | Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome. ( Aihara, N; Arakaki, Y; Kamakura, S; Kamiya, T; Kawade, M; Kurita, T; Ohe, T; Shimizu, W; Shimomura, K, 1995) |
| " In the present study, the effects of intravenous administration of prostacyclin (PGI2) and prostaglandin E2 (PGE2) on early afterdepolarizations and ventricular tachycardia induced by cesium chloride (0." | 3.68 | Prostaglandin modulation of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium chloride combined with efferent cardiac sympathetic stimulation in dogs. ( Miyazaki, T; Pride, HP; Zipes, DP, 1990) |
| " After propranolol iv it was no more possible to induce major ventricular arrhythmias anymore." | 3.67 | [Torsade de pointes during an atropine sulfate test in a patient with congenital long QT syndrome]. ( Beccaria, E; Brun, S; Conti, M; Gaita, F; Giustetto, C, 1989) |
| "Long QT syndrome is an inherited malignant channelopathy which leads to life-threatening arrhythmia, with multiple genotypes." | 1.91 | Left cardiac sympathetic denervation in children with Jervell Lange-Nielsen syndrome and drug refractory torsades - A case series. ( Bhattacharya, D; Dharan, BS; Menon, S; Namboodiri, N; Prabhu, MA; Sreelekshmi, MP; Sreevilasam Pushpangadhan, A; Valaparambil, A, 2023) |
| " Gastric involvement and achlorhydria may be present, with subsequent alteration of medication bioavailability which can trigger severe arrhythmic complications." | 1.62 | Propranolol syrup to tablets change triggers electrical storm in Jervell-Lange-Nielsen syndrome. ( Moreno-Mata, N; Moreno-Planas, J; Ramos-Jiménez, J; Sánchez-Perez, I, 2021) |
| " Chronic dosing of propranolol may be required for efficacy; therefore, we tested the efficacy of chronic treatment with either propranolol or phenytoin on RTT mice." | 1.42 | Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. ( Glaze, DG; Herrera, JA; Kaufmann, WE; Neul, JL; Percy, AK; Pitcher, MR; Skinner, S; Ward, CS; Wehrens, XH, 2015) |
| "Hypoglycemia is a potential side effect of beta-blockers; however, no cases have been reported in children with long QT syndrome (LQTS)." | 1.42 | Frequency and severity of hypoglycemia in children with beta-blocker-treated long QT syndrome. ( Ackerman, MJ; Bos, JM; Cannon, BC; Poterucha, JT, 2015) |
| "Propranolol has a significantly better QTc shortening effect compared to metoprolol and nadolol, especially in patients with prolonged QTc." | 1.38 | Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol. ( Ackerman, MJ; Beckmann, BM; Blom, NA; Chockalingam, P; Clur, SA; Crotti, L; Fischer, M; Girardengo, G; Harris, KM; Hauer, RN; Johnson, JN; Kääb, S; Rordorf, R; Rydberg, A; Schwartz, PJ; Spazzolini, C; van den Heuvel, F; van der Heijden, JF; Wilde, AA, 2012) |
| "Carvedilol has a class III antiarrhythmic effect, which may provide the rationale for a favourable clinical outcome compared with other beta-blockers as suggested in the recent COMET (Carvedilol Or Metoprolol European Trial) substudy." | 1.33 | Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. ( Abe, H; Anson, BD; Delisle, BP; January, CT; Kawakami, K; Kikuchi, K; Nagatomo, T; Nakashima, Y; Takemasa, H, 2006) |
| "Propranolol was started on all children with LQTS." | 1.31 | The congenital long QT syndrome. ( Govindakumar, PT; Joshi, V; Shahid, SK; Shanbag, P; Vaidya, M, 2002) |
| "However, the incidence of sudden death and aborted sudden death (24% in all patients and 17% in compliant patients) strongly suggests the use of a "back-up" defibrillator, particularly in noncompliant adolescent patients." | 1.30 | Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing. ( Belhassen, B; Dorostkar, PC; Eldar, M; Scheinman, MM, 1999) |
| "The right bundle branch block group had normal JT and JTc measurements, despite having prolonged QT and QTc intervals compared with controls." | 1.29 | Use of the rate-corrected JT interval for prediction of repolarization abnormalities in children. ( Berul, CI; Dubin, AM; Shah, MJ; Sweeten, TL; Vetter, VL, 1994) |
| "Torsade de pointes (TdP) syncopal episodes were almost invariably precipitated by emotional stress or menstruation in a 17-year-old girl." | 1.28 | Role of early afterdepolarization in familial long QTU syndrome and torsade de pointes. ( Liu, WY; Zheng, LR; Zhou, JT, 1992) |
| "The treatment with propranolol was most effective." | 1.28 | [A case of congenital long QT syndrome associated with T wave alternans]. ( Aoki, T; Kakuta, Y; Kasai, A; Motoyasu, M; Nishikawa, H; Ono, N; Shimizu, Y; Unno, M; Yamakado, T; Yazu, T, 1992) |
| " Prazosin produced a dose-response decrease in EAD amplitude and reduced the prevalence of VT." | 1.28 | Alpha-adrenoceptor stimulation and blockade modulates cesium-induced early afterdepolarizations and ventricular tachyarrhythmias in dogs. ( Ben-David, J; Zipes, DP, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (11.63) | 18.7374 |
| 1990's | 27 (31.40) | 18.2507 |
| 2000's | 27 (31.40) | 29.6817 |
| 2010's | 18 (20.93) | 24.3611 |
| 2020's | 4 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Comollo, TW | 1 |
| Zou, X | 1 |
| Zhang, C | 1 |
| Kesters, D | 1 |
| Hof, T | 1 |
| Sampson, KJ | 1 |
| Kass, RS | 2 |
| Bhattacharya, D | 1 |
| Namboodiri, N | 1 |
| Sreelekshmi, MP | 1 |
| Prabhu, MA | 1 |
| Sreevilasam Pushpangadhan, A | 1 |
| Menon, S | 1 |
| Dharan, BS | 1 |
| Valaparambil, A | 1 |
| Ramos-Jiménez, J | 1 |
| Sánchez-Perez, I | 1 |
| Moreno-Mata, N | 1 |
| Moreno-Planas, J | 1 |
| Vaksmann, G | 1 |
| Lucidarme, S | 1 |
| Henriet, E | 1 |
| Asatryan, B | 1 |
| Schaller, A | 1 |
| Bartholdi, D | 1 |
| Medeiros-Domingo, A | 1 |
| Wang, Y | 1 |
| Shen, T | 1 |
| Fang, P | 1 |
| Zhou, J | 2 |
| Lou, K | 1 |
| Cen, Z | 1 |
| Qian, H | 1 |
| Liu, N | 1 |
| Lian, J | 1 |
| Montnach, J | 1 |
| Chizelle, FF | 1 |
| Belbachir, N | 1 |
| Castro, C | 1 |
| Li, L | 2 |
| Loussouarn, G | 1 |
| Toumaniantz, G | 1 |
| Carcouët, A | 1 |
| Meinzinger, AJ | 1 |
| Shmerling, D | 1 |
| Benitah, JP | 1 |
| Gómez, AM | 1 |
| Charpentier, F | 1 |
| Baró, I | 1 |
| Calvillo, L | 1 |
| Spazzolini, C | 2 |
| Vullo, E | 1 |
| Insolia, R | 1 |
| Crotti, L | 4 |
| Schwartz, PJ | 8 |
| Fabritz, L | 1 |
| Franz, MR | 1 |
| Carmeliet, E | 1 |
| Kirchhof, P | 1 |
| Abu-Zeitone, A | 1 |
| Peterson, DR | 1 |
| Polonsky, B | 1 |
| McNitt, S | 1 |
| Moss, AJ | 2 |
| Herrera, JA | 1 |
| Ward, CS | 1 |
| Pitcher, MR | 1 |
| Percy, AK | 1 |
| Skinner, S | 1 |
| Kaufmann, WE | 1 |
| Glaze, DG | 1 |
| Wehrens, XH | 1 |
| Neul, JL | 1 |
| Poterucha, JT | 1 |
| Bos, JM | 1 |
| Cannon, BC | 1 |
| Ackerman, MJ | 2 |
| Kesek, M | 1 |
| Rydberg, A | 2 |
| Jensen, SM | 1 |
| Mine, T | 1 |
| Shimizu, H | 1 |
| Hiromoto, K | 1 |
| Furukawa, Y | 1 |
| Kanemori, T | 1 |
| Nakamura, H | 1 |
| Masuyama, T | 1 |
| Ohyanagi, M | 1 |
| Ahrens-Nicklas, RC | 1 |
| Clancy, CE | 1 |
| Christini, DJ | 1 |
| Bankston, JR | 1 |
| Howley, LW | 1 |
| DI Maria, M | 1 |
| Bailey, A | 1 |
| Schaffer, MS | 1 |
| Wang, DW | 2 |
| Shimizu, W | 7 |
| Pedrazzini, M | 1 |
| Cantu, F | 1 |
| De Filippo, P | 1 |
| Kishiki, K | 1 |
| Miyazaki, A | 1 |
| Ikeda, T | 1 |
| George, AL | 2 |
| Aziz, PF | 1 |
| Tanel, RE | 1 |
| Zelster, IJ | 1 |
| Pass, RH | 1 |
| Wieand, TS | 1 |
| Vetter, VL | 2 |
| Vogel, RL | 1 |
| Shah, MJ | 2 |
| Besana, A | 1 |
| Vahedi, F | 1 |
| Odenstedt, J | 1 |
| Hartford, M | 1 |
| Gilljam, T | 1 |
| Bergfeldt, L | 1 |
| Daubert, JP | 1 |
| Grant, AO | 1 |
| Nilsson, KR | 1 |
| Chockalingam, P | 1 |
| Girardengo, G | 1 |
| Johnson, JN | 1 |
| Harris, KM | 1 |
| van der Heijden, JF | 1 |
| Hauer, RN | 1 |
| Beckmann, BM | 1 |
| Rordorf, R | 1 |
| Clur, SA | 1 |
| Fischer, M | 1 |
| van den Heuvel, F | 1 |
| Kääb, S | 1 |
| Blom, NA | 1 |
| Wilde, AA | 1 |
| Chang, IK | 1 |
| Shyu, MK | 1 |
| Lee, CN | 1 |
| Kau, ML | 1 |
| Ko, YH | 1 |
| Chow, SN | 1 |
| Hsieh, FJ | 1 |
| Bosi, G | 1 |
| Cappato, R | 1 |
| Priori, SG | 3 |
| Stramba-Badiale, M | 2 |
| Farhangi, V | 1 |
| Sansone, RA | 1 |
| Li, C | 1 |
| Hu, D | 1 |
| Qin, X | 1 |
| Li, Y | 1 |
| Li, P | 1 |
| Liu, W | 1 |
| Li, Z | 1 |
| Wang, L | 1 |
| Henriksen, JH | 2 |
| Bendtsen, F | 2 |
| Hansen, EF | 1 |
| Møller, S | 2 |
| Fuglsang, S | 1 |
| Christensen, E | 1 |
| Nakagawa, M | 1 |
| Ooie, T | 1 |
| Ou, B | 1 |
| Ichinose, M | 1 |
| Takahashi, N | 1 |
| Hara, M | 1 |
| Yonemochi, H | 1 |
| Saikawa, T | 1 |
| Kawakami, K | 1 |
| Nagatomo, T | 1 |
| Abe, H | 1 |
| Kikuchi, K | 1 |
| Takemasa, H | 1 |
| Anson, BD | 1 |
| Delisle, BP | 1 |
| January, CT | 1 |
| Nakashima, Y | 1 |
| Kano, M | 1 |
| Toyoshi, T | 1 |
| Iwasaki, S | 1 |
| Kato, M | 1 |
| Shimizu, M | 1 |
| Ota, T | 1 |
| Jayakrishnan, MP | 1 |
| Krishnakumar, P | 1 |
| Drago, F | 1 |
| Fazio, G | 1 |
| Silvetti, MS | 1 |
| Oricchio, G | 1 |
| Michelon, G | 1 |
| Smith, AH | 1 |
| Norris, KJ | 1 |
| Roden, DM | 1 |
| Kannankeril, PJ | 1 |
| Thomas, G | 1 |
| Killeen, MJ | 1 |
| Grace, AA | 1 |
| Huang, CL | 1 |
| Chinushi, M | 2 |
| Izumi, D | 1 |
| Iijima, K | 1 |
| Ahara, S | 1 |
| Komura, S | 1 |
| Furushima, H | 2 |
| Hosaka, Y | 1 |
| Aizawa, Y | 2 |
| Jeyaraj, D | 1 |
| Abernethy, DP | 1 |
| Natarajan, RN | 1 |
| Dettmer, MM | 1 |
| Dikshteyn, M | 1 |
| Meredith, DM | 1 |
| Patel, K | 1 |
| Allareddy, RR | 1 |
| Lewis, SA | 1 |
| Kaufman, ES | 1 |
| Stengl, M | 1 |
| Ohe, T | 4 |
| Kurita, T | 4 |
| Tokuda, T | 1 |
| Shimomura, K | 3 |
| Kawade, M | 2 |
| Arakaki, Y | 1 |
| Aihara, N | 3 |
| Kamakura, S | 3 |
| Kamiya, T | 2 |
| Solti, F | 2 |
| Szatmáry, L | 2 |
| Vecsey, T | 2 |
| Bodor, E | 1 |
| Szabolcs, Z | 2 |
| Cieslinski, G | 1 |
| Kadel, C | 1 |
| Schräder, R | 1 |
| Klepzig, H | 1 |
| Berul, CI | 1 |
| Sweeten, TL | 1 |
| Dubin, AM | 1 |
| Noble, WE | 1 |
| Chaudhuri, P | 1 |
| Qazi, MA | 1 |
| Kajinami, K | 1 |
| Takekoshi, N | 1 |
| Mabuchi, H | 1 |
| McCurdy, CM | 1 |
| Rutherford, SE | 1 |
| Coddington, CC | 1 |
| Garson, A | 1 |
| Dick, M | 1 |
| Fournier, A | 1 |
| Gillette, PC | 1 |
| Hamilton, R | 1 |
| Kugler, JD | 1 |
| van Hare, GF | 1 |
| Vetter, V | 1 |
| Vick, GW | 1 |
| García-Rubira, JC | 1 |
| Aramburu, O | 1 |
| Romero, D | 1 |
| Valladolid, J | 1 |
| Arias, JL | 1 |
| Love, JN | 1 |
| Hanfling, D | 1 |
| Howell, JM | 1 |
| Hsieh, MH | 1 |
| Chen, SA | 1 |
| Chiang, CE | 1 |
| Tai, CT | 1 |
| Lee, SH | 1 |
| Wen, ZC | 1 |
| Chang, MS | 1 |
| Grönefeld, G | 1 |
| Höltgen, R | 1 |
| Hohnloser, SH | 1 |
| Hofbeck, M | 1 |
| Ulmer, H | 1 |
| Beinder, E | 1 |
| Sieber, E | 1 |
| Singer, H | 1 |
| Goulene, K | 1 |
| Suyama, K | 2 |
| Koçak, G | 1 |
| Atalay, S | 1 |
| Tutar, E | 1 |
| Imamoğlu, A | 1 |
| Uysalel, A | 1 |
| Güldal, M | 1 |
| Baines, DB | 1 |
| Murrell, D | 1 |
| Dorostkar, PC | 1 |
| Eldar, M | 1 |
| Belhassen, B | 1 |
| Scheinman, MM | 1 |
| Zareba, W | 1 |
| Hall, WJ | 1 |
| Crampton, RS | 1 |
| Benhorin, J | 1 |
| Vincent, GM | 1 |
| Locati, EH | 1 |
| Napolitano, C | 1 |
| Medina, A | 1 |
| Zhang, L | 1 |
| Robinson, JL | 1 |
| Timothy, K | 1 |
| Towbin, JA | 2 |
| Andrews, ML | 1 |
| Antzelevitch, C | 2 |
| Washizuka, T | 1 |
| Colzani, RM | 1 |
| Emdin, M | 1 |
| Conforti, F | 1 |
| Passino, C | 1 |
| Scarlattini, M | 1 |
| Iervasi, G | 1 |
| Shanbag, P | 1 |
| Govindakumar, PT | 1 |
| Vaidya, M | 1 |
| Joshi, V | 1 |
| Shahid, SK | 1 |
| Subramanyan, R | 1 |
| Venugopalan, P | 1 |
| Tanabe, Y | 1 |
| Aiba, T | 1 |
| Inagaki, M | 1 |
| Nagaya, N | 1 |
| Taguchi, A | 1 |
| Sunagawa, K | 1 |
| Nakamura, K | 1 |
| Yao, CT | 1 |
| Wang, JN | 1 |
| Tsai, YC | 1 |
| Lin, CS | 1 |
| Wu, JM | 1 |
| Zhou, JT | 1 |
| Zheng, LR | 1 |
| Liu, WY | 1 |
| Motoyasu, M | 1 |
| Nishikawa, H | 1 |
| Shimizu, Y | 1 |
| Aoki, T | 1 |
| Ono, N | 1 |
| Unno, M | 1 |
| Kakuta, Y | 1 |
| Yazu, T | 1 |
| Kasai, A | 1 |
| Yamakado, T | 1 |
| Ben-David, J | 1 |
| Zipes, DP | 2 |
| Popov, SV | 2 |
| Plekhanov, IG | 1 |
| Antonchenko, IV | 1 |
| Borisova, EV | 2 |
| Savenkova, GM | 1 |
| Chekhov, AM | 2 |
| Mitiutnev, AN | 1 |
| Timrikh, EO | 1 |
| Sasaki, Y | 1 |
| Hirano, K | 1 |
| Midorikawa, T | 1 |
| Kobayashi, T | 1 |
| Furihata, Y | 1 |
| Furuta, S | 1 |
| Iesaka, Y | 1 |
| Miyazaki, T | 1 |
| Pride, HP | 1 |
| Pekarskiĭ, VV | 1 |
| Gimrikh, EO | 1 |
| Savenkov, GG | 1 |
| Beccaria, E | 1 |
| Brun, S | 1 |
| Gaita, F | 1 |
| Giustetto, C | 1 |
| Conti, M | 1 |
| Pfeiffer, D | 1 |
| Fiehring, H | 1 |
| Henkel, HG | 1 |
| Rostock, KJ | 1 |
| Rathgen, K | 1 |
| Wilton, NC | 1 |
| Hantler, CB | 1 |
| Ward, DE | 1 |
| Camm, AJ | 1 |
| Bassan, J | 1 |
| Lopes, AC | 1 |
| Brilhante, JJ | 1 |
| Knobel, E | 1 |
| Zeballos, R | 1 |
| Pagura, JR | 1 |
| Gebara, M | 1 |
| Wilmer, CI | 1 |
| Stein, B | 1 |
| Morris, DC | 1 |
| Koren, G | 1 |
| Hasin, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Long QT Syndrome-Population Genetics and Cardiac Studies[NCT00005176] | 2,125 participants (Actual) | Observational | 1985-08-31 | Completed | |||
| Electromechanical Profiling of Arrhythmogenic Substrates and Triggers in the Long-QT Syndrome[NCT04074122] | 150 participants (Anticipated) | Observational | 2020-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for propranolol and Long QT Syndrome
| Article | Year |
|---|---|
Acute non-selective beta-adrenergic blockade reduces prolonged frequency-adjusted Q-T interval (QTc) in patients with cirrhosis.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Blood Pressure; Cardiac Output; Female; Heart Rat | 2004 |
Autonomic tone attenuates drug-induced QT prolongation.
Topics: Anti-Arrhythmia Agents; Atropine; Autonomic Nerve Block; Autonomic Nervous System; Dose-Response Rel | 2007 |
Influence of epinephrine, propranolol, and atrial pacing on spatial distribution of recovery time measured by body surface mapping in congenital long QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Body Surface Potential Mapping; Cardiac Pacing, Arti | 1997 |
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Female; Humans; I | 2000 |
Role of alpha1-blockade in congenital long QT syndrome: investigation by exercise stress test.
Topics: Adolescent; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-A | 2001 |
81 other studies available for propranolol and Long QT Syndrome
| Article | Year |
|---|---|
Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers.
Topics: Arrhythmias, Cardiac; Humans; Long QT Syndrome; Muscle Cells; Mutation; NAV1.5 Voltage-Gated Sodium | 2022 |
Left cardiac sympathetic denervation in children with Jervell Lange-Nielsen syndrome and drug refractory torsades - A case series.
Topics: Arrhythmias, Cardiac; Child; Heart; Humans; Infant; Jervell-Lange Nielsen Syndrome; Long QT Syndrome | 2023 |
Propranolol syrup to tablets change triggers electrical storm in Jervell-Lange-Nielsen syndrome.
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Child; Female; Humans; Jervell-Lange Nielsen Synd | 2021 |
Fetal ventricular tachycardia: betablockers should be the first line treatment.
Topics: Adrenergic beta-Antagonists; Adult; Diuretics; Female; Fetal Diseases; Fetal Monitoring; Humans; Inf | 2021 |
Late-onset severe long QT syndrome.
Topics: Aged; Anti-Arrhythmia Agents; Electrocardiography; Humans; Long QT Syndrome; Male; Propranolol; Seve | 2018 |
The role and mechanism of chaperones Calnexin/Calreticulin in which ALLN selectively rescues the trafficking defective of HERG-A561V mutation.
Topics: Calnexin; Calreticulin; ERG1 Potassium Channel; HEK293 Cells; Humans; Leupeptins; Long QT Syndrome; | 2018 |
Arrhythmias precede cardiomyopathy and remodeling of Ca
Topics: Action Potentials; Animals; Calcium; Cardiomyopathies; Disease Models, Animal; Disease Progression; | 2018 |
Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: implications for the clinical management of LQT3 patients.
Topics: Adrenergic beta-Antagonists; Animals; Cardiac Conduction System Disease; Death, Sudden, Cardiac; Dis | 2014 |
To the Editor--Propranolol, a β-adrenoreceptor blocker, prevents arrhythmias also by its sodium channel blocking effect.
Topics: Animals; Death, Sudden, Cardiac; Electrocardiography; Humans; Long QT Syndrome; Propranolol | 2014 |
Reply to the Editor--Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: implications for the clinical management of LQT3 patients.
Topics: Animals; Death, Sudden, Cardiac; Electrocardiography; Humans; Long QT Syndrome; Propranolol | 2014 |
Efficacy of different beta-blockers in the treatment of long QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Child; Child, Preschool; Death, Sudden, Ca | 2014 |
Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Arrhythmias, Cardiac; Disease Models, Animal; | 2015 |
Frequency and severity of hypoglycemia in children with beta-blocker-treated long QT syndrome.
Topics: Adrenergic beta-Antagonists; Blood Glucose; Child; Child, Preschool; Female; Humans; Hypoglycemia; I | 2015 |
Two Cases of LQT Syndrome with Malignant Syncope after Switch from Propranolol to Bisoprolol.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Bisoprolol; Drug Administration Schedule; Humans; L | 2016 |
Beat-to-beat QT interval variability is primarily affected by the autonomic nervous system.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Flutter; Atropine; Autonomic Nervous Syst | 2008 |
Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Computer Simulati | 2009 |
Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Carbazoles; Carvedilol; Cell Line; Electrophysiolog | 2010 |
Neonatal long QT syndrome type 3 predicted by positive lidocaine challenge.
Topics: Anti-Arrhythmia Agents; Bradycardia; Electrocardiography; Female; Humans; Infant, Newborn; Lidocaine | 2010 |
Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel.
Topics: Action Potentials; Anti-Arrhythmia Agents; DNA Mutational Analysis; Dose-Response Relationship, Drug | 2008 |
Congenital long QT syndrome and 2:1 atrioventricular block: an optimistic outcome in the current era.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Atrioventricular Block; Child; Child, Preschool | 2010 |
Pharmacological and non-pharmacological management of the congenital long QT syndrome: the rationale.
Topics: Adrenergic beta-Antagonists; Death, Sudden, Cardiac; Defibrillators, Implantable; Humans; Long QT Sy | 2011 |
Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome.
Topics: Adrenergic beta-Antagonists; Cell Line; Humans; Long QT Syndrome; Metoprolol; Mutation; Nadolol; NAV | 2012 |
Vectorcardiography analysis of the repolarization response to pharmacologically induced autonomic nervous system modulation in healthy subjects.
Topics: Adaptation, Physiological; Adult; Atropine; Autonomic Nervous System; Body Mass Index; Female; Heart | 2012 |
Novel insights into beta-blocker therapy for long QT syndromes.
Topics: Adrenergic beta-Antagonists; Female; Humans; Long QT Syndrome; Male; Metoprolol; Nadolol; Propranolo | 2012 |
Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Child; Disease-Free Survival; Electrocardiography; F | 2012 |
Prenatal diagnosis and treatment of fetal long QT syndrome: a case report.
Topics: Adult; Bradycardia; Bundle-Branch Block; Electrocardiography; Female; Fetal Diseases; Heart Block; H | 2002 |
Complex electrocardiographic findings in a neonate with long QT syndrome.
Topics: Anti-Arrhythmia Agents; DNA Mutational Analysis; Electrocardiography; Humans; Infant, Newborn; Long | 2002 |
QTc prolongation due to propranolol overdose.
Topics: Adolescent; Drug Overdose; Electrocardiography; Female; Humans; Long QT Syndrome; Propranolol; Sever | 2003 |
Clinical features and management of congenital long QT syndrome: a report on 54 patients from a national registry.
Topics: Adrenergic beta-Antagonists; Adult; China; Electrocardiography; Female; Humans; Long QT Syndrome; Ma | 2004 |
[Cirrhotic cardiomyopathy: prolonged QTc-interval and dyssynchronic electrical and mechanical systole in cirrhosis].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiomyopathies; Electrocardiography; Female; Heart; Hemo | 2004 |
Gender differences in autonomic modulation of ventricular repolarization in humans.
Topics: Adult; Atropine; Autonomic Nervous System; Disease Susceptibility; Electrophysiologic Techniques, Ca | 2005 |
Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.
Topics: Adrenergic beta-Antagonists; Binding Sites; Carbazoles; Cardiovascular Diseases; Carvedilol; Cell Li | 2006 |
QT PRODACT: usability of miniature pigs in safety pharmacology studies: assessment for drug-induced QT interval prolongation.
Topics: Animals; Blood Pressure; Databases, Factual; Electrocardiography; Haloperidol; Heart Rate; Long QT S | 2005 |
Macroscopic T wave alternans in long QT syndrome.
Topics: Anti-Arrhythmia Agents; Child; Electrocardiography; Female; Humans; Long QT Syndrome; Propranolol; R | 2006 |
A successfully novel ICD implantation and medical treatment in a child with LQT syndrome and self-limiting ventricular fibrillation.
Topics: Anti-Arrhythmia Agents; Child, Preschool; Combined Modality Therapy; Defibrillators, Implantable; El | 2007 |
Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in DeltaKPQ Scn5a murine hearts modelling human long QT 3 syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Electrophysiology; Dose-Response Relatio | 2008 |
Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome.
Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dogs; Epinephrine | 2008 |
I(Kr) channel blockade to unmask occult congenital long QT syndrome.
Topics: Adrenergic beta-Antagonists; Adult; Case-Control Studies; Erythromycin; Female; Humans; Long QT Synd | 2008 |
What is more dangerous in long QT 3 syndrome? Arrhythmogenic trigger or substrate?
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Electrophysiology; Electric Stimulation; Long QT Syndrome; | 2008 |
Epinephrine-induced ventricular premature complexes due to early afterdepolarizations and effects of verapamil and propranolol in a patient with congenital long QT syndrome.
Topics: Action Potentials; Adult; Cardiac Complexes, Premature; Epinephrine; Female; Humans; Long QT Syndrom | 1994 |
Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome.
Topics: Action Potentials; Adolescent; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Blood Pre | 1995 |
Characteristics of long QT with permanent bradycardia.
Topics: Adolescent; Adult; Atropine; Bradycardia; Child; Drug Therapy, Combination; Electrocardiography; Fem | 1994 |
Provocative testing and drug response in a patient with the long QT syndrome.
Topics: Adolescent; Drug Therapy, Combination; Electrocardiography; Epinephrine; Female; Humans; Isoproteren | 1995 |
[Implantable defibrillator in the long QT syndrome].
Topics: Adult; Defibrillators, Implantable; Electrocardiography; Female; Humans; Long QT Syndrome; Propranol | 1995 |
Use of the rate-corrected JT interval for prediction of repolarization abnormalities in children.
Topics: Adolescent; Adult; Bundle-Branch Block; Child; Child, Preschool; Electrocardiography; Heart; Humans; | 1994 |
Idiopathic long q-t syndrome: brief case report and discussion.
Topics: Algorithms; Electrocardiography; Female; Humans; Long QT Syndrome; Middle Aged; Propranolol; Syncope | 1994 |
Propranolol for probucol-induced QT prolongation with polymorphic ventricular tachycardia.
Topics: Electrocardiography; Female; Humans; Long QT Syndrome; Middle Aged; Probucol; Propranolol; Torsades | 1993 |
Syncope and sudden arrhythmic death complicating pregnancy. A case report of Romano-Ward syndrome.
Topics: Adrenergic beta-Antagonists; Adult; Bradycardia; Cesarean Section; Death, Sudden, Cardiac; Electric | 1993 |
The long QT syndrome in children. An international study of 287 patients.
Topics: Adrenergic beta-Antagonists; Child; Death, Sudden, Cardiac; Defibrillators, Implantable; Electrocard | 1993 |
Syncope and long QT syndrome with an initially normal QT interval.
Topics: Adult; Arousal; Electrocardiography; Female; Heart Conduction System; Humans; Long QT Syndrome; Male | 1993 |
Hemodynamic effects of calcium chloride in a canine model of acute propranolol intoxication.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Bradycardia; Calcium Chloride; Disease Models, | 1996 |
Drug-induced torsades de pointes in one patient with congenital long QT syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Astemizole; Cardiac Pacing, Artificial; Electr | 1996 |
Implantable cardioverter defibrillator therapy in a patient with the idiopathic long QT syndrome.
Topics: Adult; Anti-Arrhythmia Agents; Combined Modality Therapy; Defibrillators, Implantable; Electrocardio | 1996 |
Prenatal findings in patients with prolonged QT interval in the neonatal period.
Topics: Anti-Arrhythmia Agents; Bradycardia; Echocardiography; Electrocardiography; Female; Humans; Infant, | 1997 |
Effects of beta-adrenergic blockade on dispersion of ventricular repolarization in newborn infants with prolonged QT interval.
Topics: Adrenergic beta-Antagonists; Female; Heart Conduction System; Humans; Infant, Newborn; Long QT Syndr | 1997 |
Congenital complete atrioventricular block in an infant with long QT syndrome.
Topics: Adrenergic beta-Antagonists; Electrocardiography; Female; Heart Block; Humans; Infant; Long QT Syndr | 1998 |
Preoperative hypoglycaemia, propranolol and the Jervell and Lange-Nielsen syndrome.
Topics: Adrenergic beta-Antagonists; Fasting; Humans; Hypoglycemia; Infant; Long QT Syndrome; Male; Preopera | 1999 |
Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child; Child, Preschool; Cohort Stud | 1999 |
Differential response of transmural dispersion of repolarization and torsade de pointes to beta-adrenergic agonists and antagonists in three models of the long QT syndrome.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Electrocardiography; Humans; Ion Cha | 1999 |
Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agent | 2000 |
Hyperthyroidism is associated with lengthening of ventricular repolarization.
Topics: Adrenergic beta-Antagonists; Adult; Electrocardiography, Ambulatory; Electrolytes; Female; Follow-Up | 2001 |
The congenital long QT syndrome.
Topics: Child; Combined Modality Therapy; Female; Humans; Infant; Long QT Syndrome; Male; Pacemaker, Artific | 2002 |
Malignant familial long QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Child; Child, Preschool; Consanguinity; Humans; Infa | 2002 |
Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Body Surface Potential Mapping; Female; Heart; Heart | 2002 |
Congenital long QT syndrome with functionally impaired atrioventricular conduction: successful treatment by mexiletine and propranolol.
Topics: Drug Therapy, Combination; Heart Block; Humans; Infant, Newborn; Long QT Syndrome; Male; Mexiletine; | 2002 |
Role of early afterdepolarization in familial long QTU syndrome and torsade de pointes.
Topics: Action Potentials; Adolescent; Cardiac Pacing, Artificial; Epinephrine; Female; Heart Conduction Sys | 1992 |
[A case of congenital long QT syndrome associated with T wave alternans].
Topics: Adrenergic beta-Antagonists; Aged; Electrocardiography; Exercise Test; Female; Humans; Long QT Syndr | 1992 |
Alpha-adrenoceptor stimulation and blockade modulates cesium-induced early afterdepolarizations and ventricular tachyarrhythmias in dogs.
Topics: Adrenergic alpha-Antagonists; Animals; Cardiac Pacing, Artificial; Cesium; Dogs; Electrophysiology; | 1990 |
[Variants of diagnosis and treatment of congenital long QT syndrome].
Topics: Child, Preschool; Diagnosis, Differential; Electrocardiography; Female; Humans; Long QT Syndrome; Pa | 1991 |
[A case of Romano-Ward syndrome effectively treated by propranolol and atrial pacing].
Topics: Adult; Cardiac Pacing, Artificial; Combined Modality Therapy; Electrocardiography; Female; Heart Atr | 1991 |
Prostaglandin modulation of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium chloride combined with efferent cardiac sympathetic stimulation in dogs.
Topics: Animals; Cardiac Pacing, Artificial; Cesium; Chlorides; Dinoprostone; Dogs; Efferent Pathways; Epopr | 1990 |
[Long-term treatment of ventricular arrhythmia caused by electrocardiographic long QT syndrome].
Topics: Arrhythmias, Cardiac; Atropine; Autonomic Nerve Block; Cardiac Complexes, Premature; Child; Combined | 1988 |
[Torsade de pointes during an atropine sulfate test in a patient with congenital long QT syndrome].
Topics: Arrhythmias, Cardiac; Atropine; Cardiac Pacing, Artificial; Humans; Long QT Syndrome; Male; Middle A | 1989 |
Long QT syndrome associated with inflammatory degeneration of the stellate ganglia.
Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Inflammation; Long QT Syndrome; Pr | 1989 |
The effect of sympathetic and parasympathetic activity on QT duration. Clinical study in patients with normal and prolonged QT time.
Topics: Adult; Arrhythmias, Cardiac; Atropine; Cardiac Pacing, Artificial; Electrocardiography; Female; Huma | 1989 |
Congenital long QT syndrome: changes in QT interval during anesthesia with thiopental, vecuronium, fentanyl, and isoflurane.
Topics: Adult; Anesthesia; Arrhythmias, Cardiac; Electrocardiography; Female; Fentanyl; Heart; Humans; Hyste | 1987 |
Q-T interval syndromes.
Topics: Arrhythmias, Cardiac; Child; Child, Preschool; Electrocardiography; Heart Rate; Humans; Long QT Synd | 1988 |
[Hereditary prolonged Q-T interval syndrome: Romano-Ward type].
Topics: Adolescent; Arrhythmias, Cardiac; Combined Modality Therapy; Death, Sudden; Heart Block; Humans; Lon | 1988 |
[Long QT interval syndrome].
Topics: Adolescent; Arrhythmias, Cardiac; Electrocardiography; Humans; Long QT Syndrome; Male; Nerve Block; | 1987 |
Atrioventricular pacemaker placement in Romano-Ward syndrome and recurrent torsades de pointes.
Topics: Adult; Arrhythmias, Cardiac; Female; Humans; Long QT Syndrome; Pacemaker, Artificial; Propranolol; R | 1987 |
[Orthostatic induced ventricular tachycardia in a patient with Romano-Ward syndrome].
Topics: Adult; Arrhythmias, Cardiac; Female; Follow-Up Studies; Heart Ventricles; Humans; Hypotension, Ortho | 1985 |