Page last updated: 2024-11-03

propranolol and Leukemia

propranolol has been researched along with Leukemia in 7 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
" Furthermore, in human leukemia U937 cells, it induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage."3.81A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. ( Balzano, AL; Castellano, S; Feoli, A; La Pietra, V; Mai, A; Marinelli, L; Milite, C; Novellino, E; Sasaki, K; Sbardella, G; Tosco, A, 2015)
"Treatment with propranolol slightly enhanced the proliferation of the RC-2A cells but did not markedly alter the growth rate of two other cell lines, regardless of their beta-adrenoceptor status."1.28Expression and function of beta-adrenergic receptors in human hematopoietic cell lines. ( Andersson, LC; Kontula, KK; Mäki, T, 1992)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19902 (28.57)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Milite, C1
Feoli, A1
Sasaki, K1
La Pietra, V1
Balzano, AL1
Marinelli, L1
Mai, A1
Novellino, E1
Castellano, S1
Tosco, A1
Sbardella, G1
Yuan, Y1
Du, L1
Tan, R1
Yu, Y1
Jiang, J1
Yao, A1
Luo, J1
Tang, R1
Xiao, Y1
Sun, H1
Hajighasemi, F1
Hajighasemi, S1
Domer, FR1
Wigler, PW1
Patterson, FK1
Mäki, T1
Andersson, LC1
Kontula, KK1
Cotias, CT1
de Santana, CF1
Pinto, Kde V1

Other Studies

7 other studies available for propranolol and Leukemia

ArticleYear
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.
    Journal of medicinal chemistry, 2015, Mar-26, Volume: 58, Issue:6

    Topics: Acetylation; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Enzyme

2015
Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL.
    Journal of medicinal chemistry, 2022, 06-09, Volume: 65, Issue:11

    Topics: Histone-Lysine N-Methyltransferase; Humans; Leukemia; Methyltransferases; Myeloid-Lymphoid Leukemia

2022
Effect of propranolol on angiogenic factors in human hematopoietic cell lines in vitro.
    Iranian biomedical journal, 2009, Volume: 13, Issue:4

    Topics: Adrenergic beta-Antagonists; Carcinogens; Enzyme Activation; Humans; Jurkat Cells; Leukemia; Matrix

2009
Priapism in children with leukemia.
    Urology, 1982, Volume: 19, Issue:4

    Topics: Humans; Leukemia; Male; Priapism; Propranolol

1982
Reversal agent inhibition of the multidrug resistance pump in human leukemic lymphoblasts.
    Biochimica et biophysica acta, 1994, Jan-03, Volume: 1189, Issue:1

    Topics: Amiodarone; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine;

1994
Expression and function of beta-adrenergic receptors in human hematopoietic cell lines.
    European journal of haematology, 1992, Volume: 49, Issue:5

    Topics: Blood Cells; Blotting, Southern; Cell Division; Cell Line; Cyclic AMP; DNA; DNA, Neoplasm; Humans; I

1992
[Prevention of arrhythmia caused by chronic retamycin (complex) poisoning by using adrenergic blokaders].
    Revista do Instituto de Antibioticos, Universidade Federal de Pernambuco, 1971, Volume: 11, Issue:1

    Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Arrhythmias, Cardiac; Body Weight; Chron

1971