propranolol has been researched along with Leukemia in 7 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Furthermore, in human leukemia U937 cells, it induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage." | 3.81 | A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. ( Balzano, AL; Castellano, S; Feoli, A; La Pietra, V; Mai, A; Marinelli, L; Milite, C; Novellino, E; Sasaki, K; Sbardella, G; Tosco, A, 2015) |
| "Treatment with propranolol slightly enhanced the proliferation of the RC-2A cells but did not markedly alter the growth rate of two other cell lines, regardless of their beta-adrenoceptor status." | 1.28 | Expression and function of beta-adrenergic receptors in human hematopoietic cell lines. ( Andersson, LC; Kontula, KK; Mäki, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Milite, C | 1 |
| Feoli, A | 1 |
| Sasaki, K | 1 |
| La Pietra, V | 1 |
| Balzano, AL | 1 |
| Marinelli, L | 1 |
| Mai, A | 1 |
| Novellino, E | 1 |
| Castellano, S | 1 |
| Tosco, A | 1 |
| Sbardella, G | 1 |
| Yuan, Y | 1 |
| Du, L | 1 |
| Tan, R | 1 |
| Yu, Y | 1 |
| Jiang, J | 1 |
| Yao, A | 1 |
| Luo, J | 1 |
| Tang, R | 1 |
| Xiao, Y | 1 |
| Sun, H | 1 |
| Hajighasemi, F | 1 |
| Hajighasemi, S | 1 |
| Domer, FR | 1 |
| Wigler, PW | 1 |
| Patterson, FK | 1 |
| Mäki, T | 1 |
| Andersson, LC | 1 |
| Kontula, KK | 1 |
| Cotias, CT | 1 |
| de Santana, CF | 1 |
| Pinto, Kde V | 1 |
7 other studies available for propranolol and Leukemia
| Article | Year |
|---|---|
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.
Topics: Acetylation; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Enzyme | 2015 |
Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL.
Topics: Histone-Lysine N-Methyltransferase; Humans; Leukemia; Methyltransferases; Myeloid-Lymphoid Leukemia | 2022 |
Effect of propranolol on angiogenic factors in human hematopoietic cell lines in vitro.
Topics: Adrenergic beta-Antagonists; Carcinogens; Enzyme Activation; Humans; Jurkat Cells; Leukemia; Matrix | 2009 |
Priapism in children with leukemia.
Topics: Humans; Leukemia; Male; Priapism; Propranolol | 1982 |
Reversal agent inhibition of the multidrug resistance pump in human leukemic lymphoblasts.
Topics: Amiodarone; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; | 1994 |
Expression and function of beta-adrenergic receptors in human hematopoietic cell lines.
Topics: Blood Cells; Blotting, Southern; Cell Division; Cell Line; Cyclic AMP; DNA; DNA, Neoplasm; Humans; I | 1992 |
[Prevention of arrhythmia caused by chronic retamycin (complex) poisoning by using adrenergic blokaders].
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Arrhythmias, Cardiac; Body Weight; Chron | 1971 |