propranolol has been researched along with Innate Inflammatory Response in 78 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| "rhGH in combination with propranolol attenuates hypermetabolism and inflammation without the adverse side effects found with rhGH therapy alone." | 9.13 | Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children. ( Finnerty, CC; Herndon, DN; Jeschke, MG; Kulp, GA; Mlcak, RP; Przkora, R, 2008) |
| " The aim of this study was to determine the effects of the beta adrenergic agonist terbutaline on NGF increase caused by allergic inflammation in rats." | 7.71 | Effects of terbutaline on NGF formation in allergic inflammation of the rat. ( Amann, R; Peskar, BA; Schuligoi, R, 2001) |
| " To examine this hypothesis, we induced mild and severe adjuvant arthritis (AA) in rats and daily doses of the NSAID, ketoprofen (KT), were given to half of these rats." | 7.69 | Influence of severity of inflammation on the disposition kinetics of propranolol enantiomers in ketoprofen-treated and untreated adjuvant arthritis. ( Jamali, F; Piquette-Miller, M, 1995) |
| "Plasma concentrations after oral administration of the high extraction drug propranolol are increased in patients and animals with inflammation." | 7.67 | Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat. ( Belpaire, FM; Bogaert, MG; Chindavijak, B; de Smet, F; Fraeyman, N, 1989) |
| "A decrease of the hepatic intrinsic clearance could contribute to the increase of the plasma concentrations of alpha 1-acid glycoprotein-bound drugs such as propranolol in animals and humans with inflammation." | 7.67 | Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes. ( Belpaire, FM; Bogaert, MG; Chindavijak, B, 1988) |
| "Low doses of propranolol suppress bone resorption by inhibiting RANKL-mediated osteoclastogenesis as well as inflammatory markers without affecting haemodynamic parameters." | 5.38 | Low dose of propranolol down-modulates bone resorption by inhibiting inflammation and osteoclast differentiation. ( Barbosa-Neto, O; Clemente-Napimoga, JT; da Silva, TA; Dias-da-Silva, VJ; Lopes, AH; Madeira, MF; Miguel, CB; Napimoga, MH; Rodrigues, WF, 2012) |
| "Infantile hemangioma is a common benign pediatric tumor which shares many features with epulis, such as rich vascularity, high incidence of female patients, high hormone level and similar treatments." | 5.38 | New treatment strategy for granulomatous epulis: intralesional injection of propranolol. ( Fan, ZN; Li, KL; Liu, C; Liu, SH; Qin, ZP; Wang, YM; Wei, FC; Zhao, WJ, 2012) |
| " Kinetic parameters were derived from a two-phase physiologically based organ pharmacokinetic model." | 5.33 | Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation. ( Chang, P; Crawford, DH; Fletcher, L; Hung, DY; Roberts, MS; Siebert, GA; Whitehouse, MW, 2006) |
| "Propranolol treatment only lowered the von Willebrand factor propeptide, and slightly increased plasminogen." | 5.31 | Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol. ( Burggraaf, J; Cohen, AF; de Meyer, PH; Emeis, JJ; Lalezari, S; Pijl, H; Vischer, UM, 2001) |
| " In this study, to our knowledge, we present the first report of the effects of perioperative propranolol and/or parecoxib on peripheral regulatory T cells (Tregs) in breast cancer patients." | 5.22 | Propranolol Attenuates Surgical Stress-Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy. ( Chen, G; Li, X; Li, Y; Liang, H; Ouyang, W; Tong, J; Wu, Y; Zhou, L, 2016) |
| "rhGH in combination with propranolol attenuates hypermetabolism and inflammation without the adverse side effects found with rhGH therapy alone." | 5.13 | Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children. ( Finnerty, CC; Herndon, DN; Jeschke, MG; Kulp, GA; Mlcak, RP; Przkora, R, 2008) |
| " We have provided experimental evidence showing the suppressive effects of the nonselective β-adrenoreceptor antagonist propranolol on hyperglycemia, inflammation, and brain injury in a rat model experiencing cerebral ischemia." | 3.96 | Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke. ( Chang, CY; Chen, CJ; Chen, WY; Kuan, YH; Liao, SL; Lin, SY; Wang, YY; Wu, CC, 2020) |
| "Clonidine increased VEGF and VEGF-receptor expression, decreased HMGB1 expression, decreased lung inflammation, and improved lung tissue repair." | 3.85 | Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma. ( Alamo, IG; Efron, PA; Kannan, KB; Loftus, TJ; Millar, JK; Mohr, AM; Plazas, JM; Thomson, AJ; Whitley, EE, 2017) |
| " Simultaneous use of the beta(2)-AR antagonist propranolol augmented LPS-induced liver failure, suggesting a role of endogenous adrenoceptor-agonists in prevention of organ-failure during systemic inflammation." | 3.72 | Endotoxin-induced liver damage in rats is minimized by beta 2-adrenoceptor stimulation. ( Grootendorst, AF; Hoebe, KH; Izeboud, CA; Nijmeijer, SM; Rodenburg, RJ; van Miert, AS; Witkamp, RR, 2004) |
| " The aim of this study was to determine the effects of the beta adrenergic agonist terbutaline on NGF increase caused by allergic inflammation in rats." | 3.71 | Effects of terbutaline on NGF formation in allergic inflammation of the rat. ( Amann, R; Peskar, BA; Schuligoi, R, 2001) |
| " To examine this hypothesis, we induced mild and severe adjuvant arthritis (AA) in rats and daily doses of the NSAID, ketoprofen (KT), were given to half of these rats." | 3.69 | Influence of severity of inflammation on the disposition kinetics of propranolol enantiomers in ketoprofen-treated and untreated adjuvant arthritis. ( Jamali, F; Piquette-Miller, M, 1995) |
| "The influence of endotoxin-induced inflammation on the enantioselective pharmacokinetics of propranolol, oxprenolol, and verapamil, which bind to alpha 1-acid glycoprotein, was studied in the rat." | 3.69 | Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat. ( Belpaire, FM; Bogaert, MG; Laethem, ME; Rosseel, MT; Wijnant, P, 1994) |
| "Plasma concentrations after oral administration of the high extraction drug propranolol are increased in patients and animals with inflammation." | 3.67 | Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat. ( Belpaire, FM; Bogaert, MG; Chindavijak, B; de Smet, F; Fraeyman, N, 1989) |
| "A decrease of the hepatic intrinsic clearance could contribute to the increase of the plasma concentrations of alpha 1-acid glycoprotein-bound drugs such as propranolol in animals and humans with inflammation." | 3.67 | Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes. ( Belpaire, FM; Bogaert, MG; Chindavijak, B, 1988) |
| "Propranolol treatment did not modify obesogenic effect of HFD feeding." | 1.46 | Propranolol treatment lowers blood pressure, reduces vascular inflammatory markers and improves endothelial function in obese mice. ( Brum, PC; Carneiro, EM; da Silva Franco, N; Davel, AP; Guizoni, DM; Lubaczeuski, C; Santos-Silva, JC; Victorio, JA, 2017) |
| "We found that breast cancer is related to age greater than 50 (P ≤ 0." | 1.42 | Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2-STAT3, NF-κB, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions. ( Bañales, JM; Becerril, JL; Benítez, JG; Juárez, JJ; Navarro, MD; Zerón, HM, 2015) |
| "Rats with cerebral ischemia developed higher blood glucose, and insulin levels, and insulin resistance index, as well as hepatic gluconeogenic enzyme expression compared with the sham-treated group." | 1.40 | Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. ( Chen, CJ; Chuang, YH; Lin, SY; Sheu, WH; Tung, KC; Wang, YY, 2014) |
| "injection abolished carrageenan-evoked hyperalgesia at the doses, at which the drugs failed to alter the hypersensitivity when they were given alone." | 1.39 | Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats. ( Hong, Y; Wang, D; Zhou, X, 2013) |
| "Low doses of propranolol suppress bone resorption by inhibiting RANKL-mediated osteoclastogenesis as well as inflammatory markers without affecting haemodynamic parameters." | 1.38 | Low dose of propranolol down-modulates bone resorption by inhibiting inflammation and osteoclast differentiation. ( Barbosa-Neto, O; Clemente-Napimoga, JT; da Silva, TA; Dias-da-Silva, VJ; Lopes, AH; Madeira, MF; Miguel, CB; Napimoga, MH; Rodrigues, WF, 2012) |
| "Infantile hemangioma is a common benign pediatric tumor which shares many features with epulis, such as rich vascularity, high incidence of female patients, high hormone level and similar treatments." | 1.38 | New treatment strategy for granulomatous epulis: intralesional injection of propranolol. ( Fan, ZN; Li, KL; Liu, C; Liu, SH; Qin, ZP; Wang, YM; Wei, FC; Zhao, WJ, 2012) |
| "Obesity is associated with endothelial dysfunction and inflammation." | 1.35 | Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism. ( Fagan, K; Frye, M; McMurtry, I; Orton, EC, 2009) |
| " Kinetic parameters were derived from a two-phase physiologically based organ pharmacokinetic model." | 1.33 | Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation. ( Chang, P; Crawford, DH; Fletcher, L; Hung, DY; Roberts, MS; Siebert, GA; Whitehouse, MW, 2006) |
| "Propranolol treatment only lowered the von Willebrand factor propeptide, and slightly increased plasminogen." | 1.31 | Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol. ( Burggraaf, J; Cohen, AF; de Meyer, PH; Emeis, JJ; Lalezari, S; Pijl, H; Vischer, UM, 2001) |
| "Mechanical hyperalgesia, however, was less sensitive to inhibition by propranolol and guanethedine but significantly inhibited by phentolamine." | 1.31 | The role of the sympathetic efferents in endotoxin-induced localized inflammatory hyperalgesia and cytokine upregulation. ( Haddad, JJ; Jabbur, SJ; Massaad, CA; Poole, S; Saadé, NE; Safieh-Garabedian, B, 2002) |
| "Bradykinin-induced hyperalgesia was abolished by HOE 140 and by treatment of the paws with anti-TNF-alpha antisera." | 1.29 | Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia. ( Cunha, FQ; Ferreira, SH; Lorenzetti, BB; Poole, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (30.77) | 18.7374 |
| 1990's | 12 (15.38) | 18.2507 |
| 2000's | 17 (21.79) | 29.6817 |
| 2010's | 18 (23.08) | 24.3611 |
| 2020's | 7 (8.97) | 2.80 |
| Authors | Studies |
|---|---|
| Albrecht, W | 1 |
| Unger, A | 1 |
| Bauer, SM | 1 |
| Laufer, SA | 1 |
| Li, Y | 2 |
| Thelen, KM | 1 |
| Fernández, KM | 1 |
| Nelli, R | 1 |
| Fardisi, M | 1 |
| Rajput, M | 1 |
| Trottier, NL | 1 |
| Contreras, GA | 1 |
| Moeser, AJ | 1 |
| Albiñana, V | 1 |
| Recio-Poveda, L | 1 |
| González-Peramato, P | 1 |
| Martinez-Piñeiro, L | 1 |
| Botella, LM | 1 |
| Cuesta, AM | 1 |
| Freiha, M | 1 |
| Achim, M | 1 |
| Gheban, BA | 1 |
| Moldovan, R | 1 |
| Filip, GA | 1 |
| Gus, EI | 1 |
| Shahrokhi, S | 1 |
| Jeschke, MG | 2 |
| Lin, SY | 2 |
| Wang, YY | 2 |
| Chang, CY | 1 |
| Wu, CC | 1 |
| Chen, WY | 1 |
| Kuan, YH | 1 |
| Liao, SL | 1 |
| Chen, CJ | 2 |
| Hyoju, SK | 1 |
| Zaborina, O | 1 |
| van Goor, H | 1 |
| Mollá, B | 1 |
| Heredia, M | 1 |
| Sanz, P | 1 |
| da Silva Franco, N | 1 |
| Lubaczeuski, C | 1 |
| Guizoni, DM | 1 |
| Victorio, JA | 1 |
| Santos-Silva, JC | 1 |
| Brum, PC | 2 |
| Carneiro, EM | 1 |
| Davel, AP | 1 |
| Loftus, TJ | 1 |
| Thomson, AJ | 1 |
| Kannan, KB | 1 |
| Alamo, IG | 1 |
| Millar, JK | 1 |
| Plazas, JM | 1 |
| Whitley, EE | 1 |
| Efron, PA | 1 |
| Mohr, AM | 1 |
| Steptoe, A | 1 |
| Ronaldson, A | 1 |
| Kostich, K | 1 |
| Lazzarino, AI | 1 |
| Urbanova, L | 1 |
| Carvalho, LA | 1 |
| Sanaee, F | 1 |
| Jamali, F | 4 |
| Wang, D | 1 |
| Zhou, X | 1 |
| Hong, Y | 1 |
| Chuang, YH | 1 |
| Sheu, WH | 1 |
| Tung, KC | 1 |
| Brunyanszki, A | 1 |
| Olah, G | 1 |
| Coletta, C | 1 |
| Szczesny, B | 1 |
| Szabo, C | 1 |
| Becerril, JL | 1 |
| Benítez, JG | 1 |
| Juárez, JJ | 1 |
| Bañales, JM | 1 |
| Zerón, HM | 1 |
| Navarro, MD | 1 |
| Zhou, L | 1 |
| Li, X | 1 |
| Chen, G | 1 |
| Liang, H | 1 |
| Wu, Y | 1 |
| Tong, J | 1 |
| Ouyang, W | 1 |
| Deng, Q | 1 |
| Chen, H | 1 |
| Liu, Y | 1 |
| Xiao, F | 1 |
| Guo, L | 2 |
| Liu, D | 1 |
| Cheng, X | 1 |
| Zhao, M | 1 |
| Wang, X | 1 |
| Xie, S | 1 |
| Qi, S | 1 |
| Yin, Z | 1 |
| Gao, J | 1 |
| Chen, X | 1 |
| Wang, J | 1 |
| Guo, N | 1 |
| Ma, Y | 1 |
| Shi, M | 1 |
| Duff, S | 1 |
| Connolly, C | 1 |
| Buggy, DJ | 1 |
| Romana-Souza, B | 2 |
| Nascimento, AP | 1 |
| Monte-Alto-Costa, A | 2 |
| Zeinali, F | 1 |
| Stulberg, JJ | 1 |
| Delaney, CP | 1 |
| Frye, M | 1 |
| McMurtry, I | 1 |
| Orton, EC | 1 |
| Fagan, K | 1 |
| Porto, LC | 1 |
| Wohleb, ES | 1 |
| Hanke, ML | 1 |
| Corona, AW | 1 |
| Powell, ND | 1 |
| Stiner, LM | 1 |
| Bailey, MT | 1 |
| Nelson, RJ | 1 |
| Godbout, JP | 1 |
| Sheridan, JF | 1 |
| Rodrigues, WF | 1 |
| Madeira, MF | 1 |
| da Silva, TA | 1 |
| Clemente-Napimoga, JT | 1 |
| Miguel, CB | 1 |
| Dias-da-Silva, VJ | 1 |
| Barbosa-Neto, O | 1 |
| Lopes, AH | 1 |
| Napimoga, MH | 1 |
| Liu, C | 1 |
| Qin, ZP | 1 |
| Fan, ZN | 1 |
| Zhao, WJ | 1 |
| Wang, YM | 1 |
| Wei, FC | 1 |
| Li, KL | 1 |
| Liu, SH | 1 |
| Machado, MP | 1 |
| Rocha, AM | 1 |
| de Oliveira, LF | 1 |
| de Cuba, MB | 1 |
| de Oliveira Loss, I | 1 |
| Castellano, LR | 1 |
| Silva, MV | 1 |
| Machado, JR | 1 |
| Nascentes, GA | 1 |
| Paiva, LH | 1 |
| Savino, W | 1 |
| Junior, VR | 1 |
| Prado, VF | 1 |
| Prado, MA | 1 |
| Silva, EL | 1 |
| Montano, N | 1 |
| Ramirez, LE | 1 |
| Dias da Silva, VJ | 1 |
| Ley, EJ | 1 |
| Clond, MA | 1 |
| Bukur, M | 1 |
| Park, R | 1 |
| Chervonski, M | 1 |
| Dagliyan, G | 1 |
| Margulies, DR | 1 |
| Lyden, PD | 1 |
| Conti, PS | 1 |
| Salim, A | 1 |
| Guirguis, MS | 1 |
| Izeboud, CA | 1 |
| Hoebe, KH | 1 |
| Grootendorst, AF | 1 |
| Nijmeijer, SM | 1 |
| van Miert, AS | 1 |
| Witkamp, RR | 1 |
| Rodenburg, RJ | 1 |
| Takayama, K | 1 |
| Yuhki, K | 1 |
| Ono, K | 1 |
| Fujino, T | 1 |
| Hara, A | 1 |
| Yamada, T | 1 |
| Kuriyama, S | 1 |
| Karibe, H | 1 |
| Okada, Y | 1 |
| Takahata, O | 1 |
| Taniguchi, T | 1 |
| Iijima, T | 1 |
| Iwasaki, H | 1 |
| Narumiya, S | 1 |
| Ushikubi, F | 1 |
| Barker, LA | 1 |
| Dazin, PF | 1 |
| Levine, JD | 1 |
| Green, PG | 1 |
| Hung, DY | 1 |
| Siebert, GA | 1 |
| Chang, P | 1 |
| Whitehouse, MW | 1 |
| Fletcher, L | 1 |
| Crawford, DH | 1 |
| Roberts, MS | 1 |
| Clements, JD | 1 |
| Boost, KA | 1 |
| Flondor, M | 1 |
| Hofstetter, C | 1 |
| Platacis, I | 1 |
| Stegewerth, K | 1 |
| Hoegl, S | 1 |
| Nguyen, T | 1 |
| Muhl, H | 1 |
| Zwissler, B | 1 |
| Manni, M | 1 |
| Maestroni, GJ | 1 |
| von Montfort, C | 1 |
| Beier, JI | 1 |
| Kaiser, JP | 1 |
| Arteel, GE | 1 |
| Finnerty, CC | 1 |
| Kulp, GA | 1 |
| Przkora, R | 1 |
| Mlcak, RP | 1 |
| Herndon, DN | 1 |
| Schneider, RE | 2 |
| Bishop, H | 2 |
| Kendall, MJ | 1 |
| Quarterman, CP | 1 |
| Basran, GS | 1 |
| Paul, W | 1 |
| Morley, J | 1 |
| Turner-Warwick, M | 1 |
| Waller, DG | 1 |
| Smith, CL | 1 |
| Renwick, AG | 1 |
| George, CF | 1 |
| Nakajima, N | 1 |
| Ichinose, M | 1 |
| Takahashi, T | 1 |
| Yamauchi, H | 1 |
| Igarashi, A | 1 |
| Miura, M | 1 |
| Inoue, H | 1 |
| Takishima, T | 1 |
| Shirato, K | 1 |
| Piquette-Miller, M | 1 |
| Songür, N | 1 |
| Fujimura, M | 1 |
| Mizuhashi, K | 1 |
| Saito, M | 1 |
| Xiu, QY | 1 |
| Matsuda, T | 1 |
| Laethem, ME | 1 |
| Belpaire, FM | 6 |
| Wijnant, P | 1 |
| Rosseel, MT | 2 |
| Bogaert, MG | 6 |
| Jarreau, PH | 1 |
| D'Ortho, MP | 1 |
| Boyer, V | 1 |
| Harf, A | 1 |
| Macquin-Mavier, I | 1 |
| Ferreira, SH | 1 |
| Lorenzetti, BB | 1 |
| Cunha, FQ | 1 |
| Poole, S | 2 |
| Tang, CB | 1 |
| Quan, BW | 1 |
| Wang, XF | 1 |
| Xiong, YX | 1 |
| Wu, GH | 1 |
| Men'shikov, DD | 1 |
| Vasina, TA | 1 |
| Volenko, AV | 1 |
| Zalogueva, GV | 1 |
| Vasil'ev, VA | 1 |
| Teno, S | 1 |
| Tanabe, A | 1 |
| Nomura, K | 1 |
| Demura, H | 1 |
| Doak, GJ | 1 |
| Sawynok, J | 1 |
| Burggraaf, J | 1 |
| Lalezari, S | 1 |
| Emeis, JJ | 1 |
| Vischer, UM | 1 |
| de Meyer, PH | 1 |
| Pijl, H | 1 |
| Cohen, AF | 1 |
| Amann, R | 1 |
| Peskar, BA | 1 |
| Schuligoi, R | 1 |
| Tozawa, Y | 1 |
| Matsushima, K | 1 |
| Safieh-Garabedian, B | 1 |
| Haddad, JJ | 1 |
| Massaad, CA | 1 |
| Jabbur, SJ | 1 |
| Saadé, NE | 1 |
| Babb, J | 1 |
| Hawkins, CF | 1 |
| Hoare, AM | 1 |
| Fletcher, AJ | 1 |
| Sharpe, TJ | 1 |
| Smith, H | 1 |
| Drózdz, M | 1 |
| Kucharz, E | 1 |
| Wieczorek, M | 1 |
| Bengtsson, E | 1 |
| Rainsford, KD | 1 |
| Cooper, AL | 1 |
| Rothwell, NJ | 1 |
| Butchers, PR | 1 |
| Vardey, CJ | 1 |
| Johnson, M | 1 |
| Pfeiffer, D | 1 |
| Fiehring, H | 1 |
| Henkel, HG | 1 |
| Rostock, KJ | 1 |
| Rathgen, K | 1 |
| de Smet, F | 1 |
| Chindavijak, B | 3 |
| Fraeyman, N | 2 |
| Mugabo, P | 1 |
| Ohuchi, K | 1 |
| Hirasawa, N | 1 |
| Takeda, H | 1 |
| Asano, K | 1 |
| Watanabe, M | 1 |
| Tsurufuji, S | 1 |
| Khanna, N | 1 |
| Alkondon, M | 1 |
| Sen, P | 1 |
| Ray, A | 1 |
| Gutnisky, A | 1 |
| Gimeno, AL | 1 |
| De Rick, A | 1 |
| Dello, C | 1 |
| Weisdorf, DJ | 1 |
| Jacob, HS | 1 |
| Bourne, HR | 1 |
| Lichtenstein, LM | 1 |
| Melmon, KL | 1 |
| Henney, CS | 1 |
| Weinstein, Y | 1 |
| Shearer, GM | 1 |
| Green, KL | 2 |
| Kellett, DN | 1 |
| Bhalla, TN | 1 |
| Sinha, JN | 1 |
| Tangri, KK | 1 |
| Bhargava, KP | 1 |
| Ginsburg, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Improving Perioperative Pain Management for Laparoscopic Surgery Due to Colon Cancer Using the Ultrasound-guided Transmuscular Quadratus Lumborum Block. A Double Blind, Randomized, Placebo Controlled Trial.[NCT03570541] | Phase 4 | 69 participants (Actual) | Interventional | 2018-06-28 | Completed | ||
| Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery[NCT03974984] | 0 participants (Actual) | Observational | 2020-06-04 | Withdrawn (stopped due to Not feasable due to logistics) | |||
| Impact of Novel Thoracic Wall Blocks With Dexmetomidine on Inflammatory Markers Following Breast Cancer Surgery[NCT04860115] | 120 participants (Anticipated) | Interventional | 2021-11-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for propranolol and Innate Inflammatory Response
| Article | Year |
|---|---|
Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.
Topics: Anabolic Agents; Burns; Clonidine; Growth Hormone-Releasing Hormone; Hormones; Human Growth Hormone; | 2020 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Pharmacological management of postoperative ileus.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Modulation of inflammation and immunity by cyclic AMP.
Topics: Animals; Antibody Formation; B-Lymphocytes; Catecholamines; Cyclic AMP; Enterotoxins; Hemolytic Plaq | 1974 |
3 trials available for propranolol and Innate Inflammatory Response
| Article | Year |
|---|---|
The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Cardiovascular System; Double-Blind Method; Exer | 2018 |
Propranolol Attenuates Surgical Stress-Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Breast Neoplasms; Catecholamines; Cell Proliferation; Cell | 2016 |
Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children.
Topics: Adolescent; Adrenergic beta-Antagonists; Burns; Child; Cytokines; Drug Therapy, Combination; Energy | 2008 |
71 other studies available for propranolol and Innate Inflammatory Response
| Article | Year |
|---|---|
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclic Nucleotide | 2017 |
Developmental alterations of intestinal SGLT1 and GLUT2 induced by early weaning coincides with persistent low-grade metabolic inflammation in female pigs.
Topics: Animals; Blood Glucose; Female; Glucose; Glucose Transport Proteins, Facilitative; Inflammation; Int | 2022 |
Blockade of β2-Adrenergic Receptor Reduces Inflammation and Oxidative Stress in Clear Cell Renal Cell Carcinoma.
Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Hemangiobl | 2022 |
In Vivo Study of the Effects of Propranolol, Timolol, and Minoxidil on Burn Wound Healing in Wistar Rats.
Topics: Animals; Antioxidants; Burns; Female; Fibrosis; Inflammation; Minoxidil; Necrosis; Propranolol; Rats | 2023 |
Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke.
Topics: Adrenergic beta-Antagonists; Animals; Brain Injuries; Cell Line; Cytokines; Disease Models, Animal; | 2020 |
SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol).
Topics: Antihypertensive Agents; Antiviral Agents; Clonidine; Comorbidity; COVID-19; Disease Progression; Hu | 2020 |
Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model.
Topics: Animals; Biomarkers; Brain; Catechin; Disease Models, Animal; Gliosis; Glucans; Hippocampus; Inclusi | 2021 |
Propranolol treatment lowers blood pressure, reduces vascular inflammatory markers and improves endothelial function in obese mice.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Diet, High-Fat; Endot | 2017 |
Clonidine restores vascular endothelial growth factor expression and improves tissue repair following severe trauma.
Topics: Animals; Clonidine; HMGB1 Protein; Inflammation; Lung Injury; Propranolol; Pulmonary Edema; Rats; Ra | 2017 |
Action and disposition of the β3-agonist nebivolol in the presence of inflammation; an alternative to conventional β1-blockers.
Topics: Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-3 Receptor Agonists; A | 2014 |
Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats.
Topics: Analgesics; Animals; Arthritis; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Hy | 2013 |
Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats.
Topics: Adipose Tissue; Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocyt | 2014 |
Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cyclic AMP; Cyclic AMP | 2014 |
Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2-STAT3, NF-κB, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Cells, Cultured; Female; Gene Expression; Humans; In | 2015 |
Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model.
Topics: Adrenergic beta-Antagonists; Animals; Chemokines; Colitis; Disease Models, Animal; Inflammation; Inf | 2016 |
Propranolol improves cutaneous wound healing in streptozotocin-induced diabetic rats.
Topics: Animals; Cell Proliferation; Collagen; Diabetes Mellitus, Experimental; Granulation Tissue; Inflamma | 2009 |
Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Body Weight; Cytokines; Di | 2009 |
Cutaneous wound healing of chronically stressed mice is improved through catecholamines blockade.
Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Cell Proliferation; Drug Evaluation, Preclinic | 2010 |
β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antigens, CD; Anxiety Disorders; Behavio | 2011 |
Low dose of propranolol down-modulates bone resorption by inhibiting inflammation and osteoclast differentiation.
Topics: Acid Phosphatase; Alveolar Bone Loss; Animals; Bone Resorption; Cathepsin K; Cell Differentiation; C | 2012 |
New treatment strategy for granulomatous epulis: intralesional injection of propranolol.
Topics: Adrenergic beta-Antagonists; Female; Gingiva; Gingival Diseases; Granuloma; Hemangioma; Humans; Infa | 2012 |
Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease.
Topics: Acute Disease; Animals; Atenolol; Chagas Disease; Electrocardiography; Heart Rate; Inflammation; Mal | 2012 |
β-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury.
Topics: Adrenergic beta-Antagonists; Animals; Blotting, Western; Brain; Brain Chemistry; Brain Injuries; Glu | 2012 |
Disease-drug interaction: Reduced response to propranolol despite increased concentration in the rat with inflammation.
Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Arthritis, Experimental; Calcium Channels; E | 2003 |
Endotoxin-induced liver damage in rats is minimized by beta 2-adrenoceptor stimulation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Amin | 2004 |
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.
Topics: Animals; Blood Pressure; Dinoprost; Electrocardiography; Heart Atria; Heart Rate; Inflammation; Lipo | 2005 |
Sympathoadrenal-dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat.
Topics: Acoustic Stimulation; Adrenal Glands; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals | 2005 |
Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation.
Topics: Adrenergic beta-Antagonists; Alanine Transaminase; Algorithms; Alkaline Phosphatase; Animals; Arthri | 2006 |
Pravastatin reverses the down-regulating effect of inflammation on beta-adrenergic receptors: a disease-drug interaction between inflammation, pravastatin, and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Biological Availability; C-Reactive | 2007 |
The beta-adrenoceptor antagonist propranolol counteracts anti-inflammatory effects of isoflurane in rat endotoxemia.
Topics: Adrenergic beta-Antagonists; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; Blood Press | 2007 |
Sympathetic nervous modulation of the skin innate and adaptive immune response to peptidoglycan but not lipopolysaccharide: involvement of beta-adrenoceptors and relevance in inflammatory diseases.
Topics: Adaptation, Physiological; Adrenergic beta-Antagonists; Animals; Betaxolol; Cell Movement; Dendritic | 2008 |
Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice.
Topics: Animals; Apoptosis; Carboxylic Ester Hydrolases; Drug Interactions; Epinephrine; Ethanol; Extracellu | 2008 |
Effect of inflammatory disease on plasma concentrations of three beta-adrenoceptor blocking agents.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Proteins; Blood Sedimentation; Female; Humans; Infla | 1981 |
Adrenoceptor-agonist inhibition of the histamine-induced cutaneous response in man.
Topics: Adult; Albuterol; Female; Histamine; Histamine Antagonists; Humans; Inflammation; Male; Middle Aged; | 1982 |
Intravenous propranolol in patients with inflammation.
Topics: Adult; Aged; Arthritis, Rheumatoid; Crohn Disease; Humans; Inflammation; Injections, Intravenous; Ki | 1982 |
Bradykinin-induced airway inflammation. Contribution of sensory neuropeptides differs according to airway site.
Topics: Animals; Asthma; Atropine; Bradykinin; Capillary Permeability; Dipeptides; Evans Blue; Guinea Pigs; | 1994 |
Influence of severity of inflammation on the disposition kinetics of propranolol enantiomers in ketoprofen-treated and untreated adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; Blood Proteins; Drug Interactions; Female; Inflammation; Ketoprofe | 1995 |
Involvement of thromboxane A2 in propranolol-induced bronchoconstriction after allergic bronchoconstriction in guinea pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bridged Bicyclo Compounds; Bronch | 1994 |
Influence of endotoxin on the stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil in the rat.
Topics: Animals; Drug Interactions; Endotoxins; Inflammation; Male; Orosomucoid; Oxprenolol; Propranolol; Pr | 1994 |
Effects of capsaicin on the airway responses to inhaled endotoxin in the guinea pig.
Topics: Administration, Inhalation; Airway Resistance; Analysis of Variance; Animals; Bronchial Hyperreactiv | 1994 |
Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia.
Topics: Animals; Bradykinin; Dose-Response Relationship, Drug; Hindlimb; Hyperalgesia; Indomethacin; Inflamm | 1993 |
Influence of airway inflammatory changes on airway hyperresponsiveness in asthmatics.
Topics: Adult; Albuterol; Asthma; Beclomethasone; Bronchial Hyperreactivity; Bronchial Provocation Tests; Br | 1993 |
[Effect of drugs of various groups on the course of experimental local pyo-inflammatory processes].
Topics: Adrenergic Agents; Adrenergic beta-Antagonists; Animals; Anti-Bacterial Agents; Anticoagulants; Bact | 1995 |
Acutely exacerbated hypertension and increased inflammatory signs due to radiation treatment for metastatic pheochromocytoma.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Bone Neoplasms; Female; Heart Rate; Humans; Hyperten | 1996 |
Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes.
Topics: Animals; Edema; Formaldehyde; Indoles; Inflammation; Ketanserin; Male; Pain; Propranolol; Rats; Rats | 1997 |
Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol.
Topics: Adrenergic beta-Antagonists; Adult; Antithyroid Agents; Biomarkers; Blood Coagulation; Endothelium, | 2001 |
Effects of terbutaline on NGF formation in allergic inflammation of the rat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Antigens; Bronchoalveolar Lavage; Ed | 2001 |
Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atrial Natriuretic Factor; Catecholamin | 2002 |
The role of the sympathetic efferents in endotoxin-induced localized inflammatory hyperalgesia and cytokine upregulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic Antagonists; Adrenergic Fibers; Animals; Cytokines; Dose-Re | 2002 |
Letter: Plasma-propranolol levels in inflammation disease.
Topics: Bacterial Infections; Blood Sedimentation; Humans; Inflammation; Propranolol | 1976 |
Letter: Plasma-propranolol in inflammatory disease.
Topics: Humans; Inflammation; Propranolol | 1976 |
Effects of drugs on the acute inflammation following intraperitoneal injection of antigen into actively sensitised rats.
Topics: Adrenergic beta-Agonists; Animals; Antigens; Blood Proteins; Chromones; Ethers; Histamine Release; H | 1979 |
Morphological changes observed after stimulation or inhibition of adrenic system in rats chronically treated with hydrazinophtalazines.
Topics: Animals; Catecholamines; Epinephrine; Heart; Heart Diseases; Hemorrhage; Hydralazine; Inflammation; | 1979 |
The difference between the influence of prostaglandin and alpha-melanocyte stimulating hormone on the blood aqueous barrier.
Topics: Animals; Aqueous Humor; Eye; Eye Diseases; Inflammation; Infrared Rays; Iris; Melanocyte-Stimulating | 1977 |
The role of aspirin in gastric ulceration . Some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions.
Topics: Animals; Arthritis, Experimental; Aspirin; Atropine Derivatives; Bethanechol Compounds; Cold Tempera | 1978 |
Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antibodies; Capsaicin; Central Nervous S | 1991 |
Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung.
Topics: Adrenergic beta-Agonists; Albuterol; Histamine Release; Humans; Hypersensitivity; In Vitro Technique | 1991 |
Long QT syndrome associated with inflammatory degeneration of the stellate ganglia.
Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Inflammation; Long QT Syndrome; Pr | 1989 |
Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat.
Topics: Administration, Oral; Animals; Antipyrine; Inflammation; Injections, Intravenous; Male; Metoprolol; | 1989 |
Binding to serum alpha 1-acid glycoprotein and effect of beta-adrenoceptor antagonists in rats with inflammation.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Heart Rate; Inflammation; Injections, Intravenous; M | 1986 |
Mechanism of antianaphylactic action of beta-agonists in allergic inflammation of air pouch type in rats.
Topics: Adrenergic beta-Antagonists; Anaphylaxis; Animals; Antibodies, Anti-Idiotypic; Capillary Permeabilit | 1987 |
Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver.
Topics: Animals; Antipyrine; In Vitro Techniques; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranol | 1987 |
Mechanisms involved in the modulation of acute inflammatory response in rats by propranolol.
Topics: Acute-Phase Reaction; Animals; Dose-Response Relationship, Drug; Inflammation; Male; Propranolol; Ra | 1987 |
Effect of inflammation on the metabolism of antipyrine, lidocaine and propranolol in isolated rat hepatocytes.
Topics: Animals; Antipyrine; Inflammation; Lidocaine; Liver; Male; Proadifen; Propranolol; Rats; Rats, Inbre | 1988 |
Intestinal iron absorption during turpentine sterile inflammation in the rat. Influences of isoproterenol and propranolol.
Topics: Animals; Female; Inflammation; Intestinal Absorption; Iron; Isoproterenol; Liver; Propranolol; Rats; | 1987 |
Alpha 1-acid glycoprotein and serum binding of drugs in healthy and diseased dogs.
Topics: Animals; Blood Sedimentation; Diazepam; Digitoxin; Dog Diseases; Dogs; Female; Inflammation; Lidocai | 1987 |
Beta-adrenergic blockade: augmentation of neutrophil-mediated inflammation.
Topics: Alprenolol; Animals; Cell Adhesion; Cell Aggregation; Cell Movement; Chemotaxis, Leukocyte; Glucuron | 1987 |
Mechanism of the pro-inflammatory activity of sympathomimetic amines in thermic oedema of the rat paw.
Topics: Animals; Blood Circulation; Bradykinin; Capillary Permeability; Edema; Epinephrine; Foot; Heparin; H | 1974 |
2-Deoxyglucose and inflammation.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Catecholamines; Drug Antagonism; Edema; Female; Hexoses; In | 1966 |
Mechanism of anti-inflammatory activity of -adrenoceptor blocking agents.
Topics: 1-Propanol; Adrenal Glands; Adrenalectomy; Adrenergic beta-Antagonists; Amino Alcohols; Animals; Ant | 1972 |
A pro-inflammatory effect of adrenaline in thermal injury.
Topics: Animals; Blood Circulation; Bradykinin; Burns; Drug Synergism; Duodenum; Edema; Epinephrine; Female; | 1973 |