Page last updated: 2024-11-03

propranolol and Injuries

propranolol has been researched along with Injuries in 15 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Injuries: Used with anatomic headings, animals, and sports for wounds and injuries. Excludes cell damage, for which pathology is used.

Research Excerpts

ExcerptRelevanceReference
"Forty-five severely injured trauma patients were studied in a prospective, randomized pilot trial."2.79Early propranolol administration to severely injured patients can improve bone marrow dysfunction. ( Alzate, WD; Bible, LE; Gore, AV; Livingston, DH; Mohr, AM; Pasupuleti, LV; Sifri, ZC; Song, KJ, 2014)
"Six-week PTSD symptoms and heart rate were assessed."2.75The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: a pilot study. ( Browne, L; Christopher, NC; Crow, JP; Delahanty, DL; Nugent, NR; Ostrowski, S, 2010)
"Propranolol and clonidine were administered by daily intraperitoneal injection until sacrifice on day seven."1.56Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress. ( Brakenridge, SC; Efron, PA; Kannan, KB; Loftus, TJ; Mira, JC; Mohr, AM, 2020)
"Propranolol (βB) was given immediately following resuscitation."1.37β-blockade protection of bone marrow following trauma: the role of G-CSF. ( Alzate, WD; Baranski, GM; Elhassan, IO; Hannoush, EJ; Livingston, DH; Mohr, AM; Offin, MD; Rameshwar, P; Sifri, ZC, 2011)
"Propranolol pretreatment blocked macrophage arginase activity induced by epinephrine (10 mumol/L) in vitro (P < ."1.31Beta adrenoceptor regulation of macrophage arginase activity. ( Arden, WA; Bernard, AC; Boulanger, BR; Fitzpatrick, EA; Gellin, GL; Kearney, PA; Maley, ME; Ochoa, JB; Tsuei, BJ, 2000)
"This increased resistance to a lethal trauma in rats conditioned by drummings with concurrent administration of propranolol was confirmed in another lot of rats."1.27Effect of beta-receptor blockade on the development of resistance to trauma in rats. ( Asoh, T; Shirasaka, C; Takeuchi, Y; Tsuji, H, 1983)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19904 (26.67)18.7374
1990's0 (0.00)18.2507
2000's4 (26.67)29.6817
2010's6 (40.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Loftus, TJ1
Kannan, KB1
Mira, JC1
Brakenridge, SC1
Efron, PA1
Mohr, AM3
Bible, LE1
Pasupuleti, LV1
Alzate, WD2
Gore, AV1
Song, KJ1
Sifri, ZC2
Livingston, DH2
Xu, L1
Yu, WK1
Lin, ZL1
Tan, SJ1
Bai, XW1
Ding, K1
Li, N1
Romana-Souza, B3
Nascimento, AP1
Monte-Alto-Costa, A3
Nugent, NR1
Christopher, NC1
Crow, JP1
Browne, L1
Ostrowski, S1
Delahanty, DL1
Porto, LC1
Bryant, RA1
Baranski, GM1
Offin, MD1
Elhassan, IO1
Hannoush, EJ1
Rameshwar, P1
Stein, MB1
Kerridge, C1
Dimsdale, JE1
Hoyt, DB1
Asoh, T1
Tsuji, H1
Shirasaka, C1
Takeuchi, Y1
Tischler, ME1
Palma, JA1
Enders, J1
de Oliva, PP1
Bernard, AC1
Fitzpatrick, EA1
Maley, ME1
Gellin, GL1
Tsuei, BJ1
Arden, WA1
Boulanger, BR1
Kearney, PA1
Ochoa, JB1
Vigas, M1
Németh, S1
Kvetnanský, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Protocol for a Controlled Trial of Early Intervention With Children and Adolescents Exposed to Nonrelational Traumatic Events Comparing Trauma-informed and Usual Health Care Practice[NCT02299583]684 participants (Anticipated)Interventional2014-10-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for propranolol and Injuries

ArticleYear
Early intervention for post-traumatic stress disorder.
    Early intervention in psychiatry, 2007, Volume: 1, Issue:1

    Topics: Cognitive Behavioral Therapy; Humans; Primary Prevention; Propranolol; Randomized Controlled Trials

2007
Hormonal regulation of protein degradation in skeletal and cardiac muscle.
    Life sciences, 1981, Jun-08, Volume: 28, Issue:23

    Topics: Adrenalectomy; Alanine; Animals; Corticosterone; Diabetes Mellitus, Experimental; Epinephrine; Fasti

1981

Trials

3 trials available for propranolol and Injuries

ArticleYear
Early propranolol administration to severely injured patients can improve bone marrow dysfunction.
    The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:1

    Topics: Adult; Bone Marrow; Female; Heart Rate; Hematopoietic Stem Cell Mobilization; Humans; Injury Severit

2014
The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: a pilot study.
    Journal of traumatic stress, 2010, Volume: 23, Issue:2

    Topics: Adolescent; Adrenergic beta-Antagonists; Child; Double-Blind Method; Emergencies; Female; Humans; Li

2010
Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients.
    Journal of traumatic stress, 2007, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Amines; Anti-Anxiety Agents; California; Cyclohexanecarboxylic Acids; Female; Gab

2007

Other Studies

10 other studies available for propranolol and Injuries

ArticleYear
Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
    Shock (Augusta, Ga.), 2020, Volume: 54, Issue:4

    Topics: Animals; Clonidine; Corticosterone; Enzyme-Linked Immunosorbent Assay; Hematopoietic Stem Cells; Hep

2020
Impact of β-adrenoceptor blockade on systemic inflammation and coagulation disturbances in rats with acute traumatic coagulopathy.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, Feb-12, Volume: 21

    Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Blood Coagulation Disorders; Blotting, W

2015
Propranolol improves cutaneous wound healing in streptozotocin-induced diabetic rats.
    European journal of pharmacology, 2009, Jun-02, Volume: 611, Issue:1-3

    Topics: Animals; Cell Proliferation; Collagen; Diabetes Mellitus, Experimental; Granulation Tissue; Inflamma

2009
Simultaneous blockade of alpha and beta adrenoceptors impairs cutaneous wound healing in rats.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2010, Volume: 24, Issue:3

    Topics: Administration, Cutaneous; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cell

2010
Cutaneous wound healing of chronically stressed mice is improved through catecholamines blockade.
    Experimental dermatology, 2010, Volume: 19, Issue:9

    Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Cell Proliferation; Drug Evaluation, Preclinic

2010
β-blockade protection of bone marrow following trauma: the role of G-CSF.
    The Journal of surgical research, 2011, Volume: 170, Issue:2

    Topics: Adrenergic beta-Antagonists; Anemia; Animals; Bone Marrow; Catecholamines; Contusions; Granulocyte C

2011
Effect of beta-receptor blockade on the development of resistance to trauma in rats.
    Circulatory shock, 1983, Volume: 11, Issue:3

    Topics: Adaptation, Physiological; Adrenergic beta-Antagonists; Animals; Male; Propranolol; Rats; Rats, Inbr

1983
Effects of epinephrine on plasma fibrinogen levels in rats submitted to tissue injury.
    Experientia, 1981, Jul-15, Volume: 37, Issue:7

    Topics: Adrenal Medulla; Adrenalectomy; Animals; Epinephrine; Female; Fibrinogen; Laparotomy; Male; Phenoxyb

1981
Beta adrenoceptor regulation of macrophage arginase activity.
    Surgery, 2000, Volume: 127, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Anima

2000
Lack of effects of adrenergic blockade, adrenal medullectomy and medullectomy combined with reserpine treatment on the metabolic response to injury.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1973, Volume: 5, Issue:1

    Topics: Adrenal Medulla; Animals; Catecholamines; Ergotamine; Glycogen Storage Disease; Lactates; Liver Glyc

1973