propranolol and Infant, Newborn, Diseases studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.

Research Excerpts

Excerpt	Relevance	Reference
"A number of clinical trials evaluated the effect of topical timolol in the treatment of infantile hemangioma and provided inconsistent results."	8.98	Effect of topical timolol on response rate and adverse events in infantile hemangioma: a meta-analysis. ( Li, Y; Zheng, L, 2018)
"A newborn with unresectable kaposiform hemangioendothelioma associated with Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second-line treatment with propranolol at a dose of 2 mg/kg/day, starting at 2 months of life and continued for 13 months."	7.83	Successful Propranolol Treatment of a Kaposiform Hemangioendothelioma Apparently Resistant to Propranolol. ( Berti, E; Calvani, M; Defilippi, C; Della Bona, ML; Donzelli, G; Favre, C; Filippi, L; la Marca, G; Perrone, A; Tamburini, A, 2016)
"A combination of propranolol and hydrallazine was administered to 13 patients with longstanding hypertension during 15 pregnancies."	7.66	Propranolol and hydrallazine in the management of essential hypertension in pregnancy. ( Bott-Kanner, G; Joel-Cohen, SJ; Reisner, SH; Rosenfeld, JB; Schweitzer, A, 1980)
"The administration of 160 mg of propranolol during pregnancy, labor, and delivery was associated with profound hypoglycemia and respiratory depression in a newborn infant."	7.65	Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition. ( Cottrill, CM; Gettes, L; McAllister, RG; Noonan, JA, 1977)
"Propranolol was added to the medical treatment and was administered orally in doses ranging from 7 to 14 mg/kg/day (average 9 mg/kg/day)."	5.26	High-dose propranolol therapy in the management of supraventricular tachycardia. ( Ferrer, PL; Garcia, O; Gelband, H; Pickoff, AS; Tamer, D; Wolff, G; Zies, L, 1979)
"A number of clinical trials evaluated the effect of topical timolol in the treatment of infantile hemangioma and provided inconsistent results."	4.98	Effect of topical timolol on response rate and adverse events in infantile hemangioma: a meta-analysis. ( Li, Y; Zheng, L, 2018)
"A newborn with unresectable kaposiform hemangioendothelioma associated with Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second-line treatment with propranolol at a dose of 2 mg/kg/day, starting at 2 months of life and continued for 13 months."	3.83	Successful Propranolol Treatment of a Kaposiform Hemangioendothelioma Apparently Resistant to Propranolol. ( Berti, E; Calvani, M; Defilippi, C; Della Bona, ML; Donzelli, G; Favre, C; Filippi, L; la Marca, G; Perrone, A; Tamburini, A, 2016)
"A combination of propranolol and hydrallazine was administered to 13 patients with longstanding hypertension during 15 pregnancies."	3.66	Propranolol and hydrallazine in the management of essential hypertension in pregnancy. ( Bott-Kanner, G; Joel-Cohen, SJ; Reisner, SH; Rosenfeld, JB; Schweitzer, A, 1980)
"The administration of 160 mg of propranolol during pregnancy, labor, and delivery was associated with profound hypoglycemia and respiratory depression in a newborn infant."	3.65	Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition. ( Cottrill, CM; Gettes, L; McAllister, RG; Noonan, JA, 1977)
"In both cancer and embryo, β3-ARs exert similar functions by exploiting a metabolic shift known as the Warburg effect, by acquiring resistance against xenobiotics, and by inducing a local immune tolerance."	2.82	β3-Adrenoceptor, a novel player in the round-trip from neonatal diseases to cancer: Suggestive clues from embryo. ( Bagnoli, P; Cammalleri, M; Dal Monte, M; Filippi, L; Pini, A, 2022)
"Propranolol was detected by use of a spectrofluorometer equipped with a 20-microL flow-through cell, at excitation and emission wavelengths of 250 and 336 nm."	1.27	Determination of propranolol in plasma by radial compression liquid chromatography with fluorometric detection. ( el-Yazigi, A; Martin, CR, 1985)
"Propranolol was added to the medical treatment and was administered orally in doses ranging from 7 to 14 mg/kg/day (average 9 mg/kg/day)."	1.26	High-dose propranolol therapy in the management of supraventricular tachycardia. ( Ferrer, PL; Garcia, O; Gelband, H; Pickoff, AS; Tamer, D; Wolff, G; Zies, L, 1979)

Research

Studies (35)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Duration of Latent

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (85.71)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (8.57)	24.3611
2020's	2 (5.71)	2.80

Authors	Studies
Filippi, L	3
Pini, A	2
Cammalleri, M	2
Bagnoli, P	2
Dal Monte, M	2
Scaramuzzo, RT	1
Ballini, S	1
Bendinelli, A	1
Desideri, I	1
Ciantelli, M	1
Zheng, L	1
Li, Y	1
Samuels, SL	1
Namoc, SM	1
Bauer, AJ	1
Tamburini, A	1
Berti, E	1
Perrone, A	1
Defilippi, C	1
Favre, C	1
Calvani, M	1
Della Bona, ML	1
la Marca, G	1
Donzelli, G	1
Burr, WA	1
de Sarasqueta, P	1
Clavijo, F	1
Valencia, G	1
Kaufman, S	1
Gardner, LI	1
Eason, E	1
Costom, B	1
Papageorgiou, AN	1
Saraiva, LR	1
Raposo, L	1
Rodrigues, R	1
Brandt, C	1
Villachan, R	1
Bott-Kanner, G	1
Schweitzer, A	1
Reisner, SH	1
Joel-Cohen, SJ	1
Rosenfeld, JB	1
Newman, TJ	1
Virnig, NL	1
Athinarayanan, PR	1
Eibschitz, I	1
Abinader, EG	1
Klein, A	1
Sharf, M	1
Serup, J	1
Beitzke, A	1
Pruyn, SC	1
Phelan, JP	1
Buchanan, GC	1
Ayabe, T	1
Chiemmongkoltip, P	1
Adelman, RD	1
Merten, D	1
Vogel, J	1
Goetzman, BW	1
Wennberg, RP	1
Pickoff, AS	1
Zies, L	1
Ferrer, PL	1
Tamer, D	1
Wolff, G	1
Garcia, O	1
Gelband, H	2
Sung, RJ	1
Ferrer, P	1
Garcia, OL	1
Castellanos, A	1
Habib, A	1
McCarthy, JS	1
Cottrill, CM	1
McAllister, RG	1
Gettes, L	1
Noonan, JA	1
Kostrzewski, JM	1
Kościelniak, W	1
Mitchell, I	1
Shenfield, G	1
Brash, J	1
Frey, H	1
Siegler, RL	1
el-Yazigi, A	1
Martin, CR	1
Hurwitz, RA	1
Fiddler, GI	1
Pemberton, PJ	1
McConnell, B	1
Shanks, RG	1
Greig, WR	1
Wanderman, KL	1
Faber, J	1
Smith, CS	1
Howard, NJ	1
Tunstall, ME	1
Gallez, A	1
Polis, O	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients: a Double-blind Randomized Controlled Trial[NCT03348683]	Phase 2	240 participants (Actual)	Interventional	2017-12-11	Completed
Propranolol for Prolonged Labor: A Randomized Controlled Trial (PRO-Labor Trial)[NCT04741698]	Phase 1	80 participants (Actual)	Interventional	2021-07-27	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Time of latent labor defined as <6cm of cervical dilation. (NCT03348683)
Timeframe: average of 24 hours

Number of Fetus With Fetal Bradycardia

Intervention	hours (Mean)
Propranolol	11.0
Placebo	11.2

Count of fetus with fetal bradycardia (<110bpm for >10 minutes within 30 minutes of study drug administration) (NCT03348683)
Timeframe: 30 minutes from drug administration

Number of Fetus With Heart Rate Decelerations

Intervention	Participants (Count of Participants)
Propranolol	1
Placebo	0

Count of fetus with fetal heart rate decelerations within 30 minutes of study drug administration (NCT03348683)
Timeframe: 30 minutes from drug administration

Number of Neonates With Hypoglycemia

Intervention	Participants (Count of Participants)
Propranolol	15
Placebo	13

"Neonatal outcome - Number of neonates with hypoglycemia (blood glucose <50).~This population includes only the neonates who had heelsticks to check their blood glucose, which is not a universal practice and was not required by the protocol or IRB. The neonates included were those who met the nursery's risk-based protocol to check blood glucose after birth (ex: infants of diabetic mothers, fetal growth restriction, macrosomia, or symptoms suggestive of hypoglycemia)" (NCT03348683)
Timeframe: Day 1

Number of Neonates With Neonatal Outcome Composite Score = 1

Intervention	Participants (Count of Participants)
Propranolol	11
Placebo	8

"Composite neonatal outcome score was for any of the following morbidity: Neonatal Intensive Care Unit (NICU) admission, respiratory support (CPAP, nasal cannula, intubation), culture proven sepsis, radiographically proven intracranial hemorrhage, necrotizing enterocolitis, hypoglycemia (for those infants who had sugar checked), and neonatal death.~The composite score was computed as a score of 1 for any indication of neonatal morbidity - neonates who experienced at least one morbidity and the components are given equal weights. Patients who had no evidence of the predefined neonatal morbidities are subsequently given a score of 0. The minimum is 0 and maximum is 1." (NCT03348683)
Timeframe: Day 1

Number of Participants With Maternal Morbidity Composite Score = 1

Intervention	Participants (Count of Participants)
Propranolol	21
Placebo	28

"Composite maternal morbidity score consists of a count of postpartum hemorrhage, transfusion, hysterectomy, placental abruption, chorioamnionitis, shoulder dystocia, episiotomy, higher order laceration, and ICU admission.~The composite score was computed as a score of 1 for any indication of maternal morbidity, that is the participant experienced at least one maternal morbidity, and the components are given equal weights. Participants who had no evidence of the predefined maternal morbidities are subsequently given a score of 0. The minimum is 0 and maximum is 1." (NCT03348683)
Timeframe: average of 24 hours

Number of Participants With Postpartum Hemorrhage

Intervention	Participants (Count of Participants)
Propranolol	35
Placebo	49

Greater than 500cc of blood expelled during a vaginal delivery or greater than 1000cc of blood expelled during a cesarean section (NCT03348683)
Timeframe: 30 minutes from drug administration

Time From Beginning of Induction to Delivery

Intervention	Participants (Count of Participants)
Propranolol	15
Placebo	26

The time of induction (based on time of foley balloon placement for cervical ripening or misoprostol administration) to the time of delivery of the infant. (NCT03348683)
Timeframe: average of 24 hours

Number of Participants With Various Mode of Delivery

Intervention	hours (Mean)
Propranolol	13.8
Placebo	14.3

Number of various mode of delivery - count of Vaginal delivery, vacuum assisted vaginal delivery, forceps assisted vaginal delivery, cesarean section (NCT03348683)
Timeframe: average of 24 hours

Article	Year
β3-Adrenoceptor, a novel player in the round-trip from neonatal diseases to cancer: Suggestive clues from embryo. Medicinal research reviews, 2022, Volume: 42, Issue:3 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Neoplasms; Propranolol; Receptors, Adrenergic; R	2022
Effect of topical timolol on response rate and adverse events in infantile hemangioma: a meta-analysis. Archives of dermatological research, 2018, Volume: 310, Issue:4 Topics: Administration, Topical; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions;	2018
Neonatal Thyrotoxicosis. Clinics in perinatology, 2018, Volume: 45, Issue:1 Topics: Adrenergic beta-Antagonists; Antithyroid Agents; Female; Fetal Diseases; Graves Disease; Humans; Hyp	2018
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. American journal of diseases of children (1960), 1980, Volume: 134, Issue:9 Topics: Adult; Bradycardia; Child; Child, Preschool; Female; Fetus; Humans; Hyperthyroidism; Hypoglycemia; I	1980
[Thyrotoxicosis in connection with pregnancy and delivery. Review of obstetric, medical and pediatric aspects]. Ugeskrift for laeger, 1978, Jul-31, Volume: 140, Issue:31 Topics: Antithyroid Agents; Female; Fetal Diseases; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newbor	1978
Cardiac arrhythmias in infants and children. Current problems in pediatrics, 1973, Volume: 3, Issue:6 Topics: Adolescent; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Bradycardi	1973
Treatment of thyrotoxicosis--the current position. 3. Radioiodine therapy. Special considerations. Current medical research and opinion, 1973, Volume: 1, Issue:6 Topics: Adult; Age Factors; Carbimazole; Chlorpromazine; Female; Heart Diseases; Humans; Hyperthyroidism; Hy	1973

Article	Year
Treating infants with 0.2% propranolol eye micro-drops drastically reduced the progression of retinopathy of prematurity. Acta paediatrica (Oslo, Norway : 1992), 2023, Volume: 112, Issue:9 Topics: Disease Progression; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; In	2023
Successful Propranolol Treatment of a Kaposiform Hemangioendothelioma Apparently Resistant to Propranolol. Pediatric blood & cancer, 2016, Volume: 63, Issue:7 Topics: Drug Resistance, Neoplasm; Hemangioendothelioma; Humans; Infant, Newborn; Infant, Newborn, Diseases;	2016
Prescribing in pregnancy. Thyroid disease. Clinics in obstetrics and gynaecology, 1981, Volume: 8, Issue:2 Topics: Antithyroid Agents; Carbimazole; Female; Fetus; Humans; Hyperthyroidism; Hypothyroidism; Infant, New	1981
[Transitory neonatal hyperthyroidism. Report of a case treated with propranolol]. Boletin medico del Hospital Infantil de Mexico, 1982, Volume: 39, Issue:12 Topics: Female; Graves Disease; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Pregnan	1982
Hypertension in neonatal thyrotoxicosis. The Journal of pediatrics, 1982, Volume: 100, Issue:5 Topics: Female; Humans; Hypertension; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Propranol	1982
[Cardiac dysrhythmia in the newborn infant. Observations in the nursery of a general hospital]. Arquivos brasileiros de cardiologia, 1981, Volume: 37, Issue:2 Topics: Arrhythmias, Cardiac; Digoxin; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; H	1981
Propranolol and hydrallazine in the management of essential hypertension in pregnancy. British journal of obstetrics and gynaecology, 1980, Volume: 87, Issue:2 Topics: Adult; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Hypoglycemia; Infant, N	1980
Complications of propranolol use in neonatal thyrotoxicosis. American journal of diseases of children (1960), 1980, Volume: 134, Issue:7 Topics: Bradycardia; Female; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Propranolo	1980
Intrauterine diagnosis and control of fetal ventricular arrhythmia during labor. American journal of obstetrics and gynecology, 1975, Jul-01, Volume: 122, Issue:5 Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electrocardiography; Female; Fetal Diseas	1975
[Multifocal (chaotic) atrial tachycardia in infancy]. Helvetica paediatrica acta, 1979, Volume: 34, Issue:4 Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Electrocardiography; Heart Rate; Humans; Infan	1979
Long-term propranolol therapy in pregnancy: maternal and fetal outcome. American journal of obstetrics and gynecology, 1979, Oct-15, Volume: 135, Issue:4 Topics: Asphyxia Neonatorum; Bradycardia; Female; Fetal Growth Retardation; Fetus; Humans; Hypertension; Hyp	1979
Long-term propranolol therapy in pregnancy: maternal and fetal outcome. American journal of obstetrics and gynecology, 1979, Oct-15, Volume: 135, Issue:4 Topics: Asphyxia Neonatorum; Bradycardia; Female; Fetal Growth Retardation; Fetus; Humans; Hypertension; Hyp	1979
Long-term propranolol therapy in pregnancy: maternal and fetal outcome. American journal of obstetrics and gynecology, 1979, Oct-15, Volume: 135, Issue:4 Topics: Asphyxia Neonatorum; Bradycardia; Female; Fetal Growth Retardation; Fetus; Humans; Hypertension; Hyp	1979
Long-term propranolol therapy in pregnancy: maternal and fetal outcome. American journal of obstetrics and gynecology, 1979, Oct-15, Volume: 135, Issue:4 Topics: Asphyxia Neonatorum; Bradycardia; Female; Fetal Growth Retardation; Fetus; Humans; Hypertension; Hyp	1979
Persistent ventricular tachycardia in a newborn infant. Symptomatic control for over 18 months with propranolol. Clinical pediatrics, 1978, Volume: 17, Issue:1 Topics: Female; Heart Ventricles; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Small	1978
Nonsurgical management of renovascular hypertension in the neonate. Pediatrics, 1978, Volume: 62, Issue:1 Topics: Adult; Antihypertensive Agents; Diazoxide; Diuretics; Female; Humans; Hydralazine; Hypertension, Ren	1978
High-dose propranolol therapy in the management of supraventricular tachycardia. The Journal of pediatrics, 1979, Volume: 94, Issue:1 Topics: Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; P	1979
Atrioventricular reciprocal rhythm and chronic reciprocating tachycardia in a newborn infant with concealed Wolff-Parkinson-White syndrome. British heart journal, 1977, Volume: 39, Issue:7 Topics: Cardiac Catheterization; Digoxin; Electrophysiology; Heart Block; Heart Conduction System; Humans; I	1977
Effects on the neonate of propranolol administered during pregnancy. The Journal of pediatrics, 1977, Volume: 91, Issue:5 Topics: Bradycardia; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Jaundice, Neo	1977
Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition. The Journal of pediatrics, 1977, Volume: 91, Issue:5 Topics: Adult; Apnea; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Matern	1977
[Cured tetanus in a newborn infant]. Przeglad epidemiologiczny, 1977, Volume: 31, Issue:3 Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Propranolol; Tetanus	1977
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). Archives of disease in childhood, 1976, Volume: 51, Issue:7 Topics: Adult; Female; Fetal Blood; Humans; Hyperthyroidism; Immunoglobulins; Infant; Infant, Newborn; Infan	1976
[Drug treatment of thyrotoxicosis during pregnancy]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Oct-10, Volume: 96, Issue:28 Topics: Female; Fetus; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newborn, Diseases; Iodine; Maternal	1976
Conservative management of neonatal renal artery embolism. Urology, 1976, Volume: 8, Issue:5 Topics: Aortography; Blood Flow Velocity; Catheterization; Drug Therapy, Combination; Embolism; Humans; Hydr	1976
Determination of propranolol in plasma by radial compression liquid chromatography with fluorometric detection. Clinical chemistry, 1985, Volume: 31, Issue:7 Topics: Chromatography, Liquid; Female; Fluorometry; Humans; Hypertension; Infant, Newborn; Infant, Newborn,	1985
Letter: Propranolol and pregnancy. Lancet (London, England), 1974, Sep-21, Volume: 2, Issue:7882 Topics: Adult; Birth Weight; Cardiomegaly; Female; Fetus; Humans; Hypoglycemia; Infant, Newborn; Infant, New	1974
Neonatal thyrotoxicosis treated with propranolol. Archives of disease in childhood, 1974, Volume: 49, Issue:10 Topics: Adult; Female; Heart Rate; Humans; Hyperthyroidism; Infant Nutritional Physiological Phenomena; Infa	1974
[Spontaneous disappearance of Wolff-Parkinson-White syndrome in an infant]. Harefuah, 1973, Apr-15, Volume: 84, Issue:8 Topics: Digitalis Glycosides; Electrocardiography; Humans; Infant; Infant, Newborn; Infant, Newborn, Disease	1973
Propranolol in treatment of neonatal thyrotoxicosis. The Journal of pediatrics, 1973, Volume: 83, Issue:6 Topics: Administration, Oral; Body Weight; Female; Heart Rate; Humans; Hyperthyroidism; Infant, Newborn; Inf	1973
The effect of propranolol on the onset of breathing at birth. British journal of anaesthesia, 1969, Volume: 41, Issue:9 Topics: Anesthesia, Obstetrical; Cesarean Section; Female; Humans; Infant, Newborn; Infant, Newborn, Disease	1969
[Paroxysmal tachycardia in infants and its treatment. Apropos of a case of recurrent paroxysmal tachycardia treated by propranolol]. Malattie cardiovascolari, 1969, Volume: 10, Issue:3 Topics: Age Factors; Chronic Disease; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pr	1969

propranolol and Infant, Newborn, Diseases