Page last updated: 2024-11-03

propranolol and Hyperkalemia

propranolol has been researched along with Hyperkalemia in 37 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Propranolol has been widely used in the treatment of infantile hemangiomas since 2008."9.22Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas. ( Chang, L; Chen, H; Hu, L; Huang, H; Jin, Y; Li, W; Lin, X; Ma, G; Qiu, Y; Xu, X; Zhou, B, 2016)
"A 33-day-old female with an ulcerated infantile hemangioma (IH) undergoing oral therapy with propranolol 2 mg/kg per day developed hyperkalemia and hyperphosphatemia 24 h after starting medication."7.78Tumor lysis syndrome after propranolol therapy in ulcerative infantile hemangioma: rare complication or incidental finding? ( Buffon, RB; Cavalli, R; Colli, AM; de Souza, M; Gelmetti, C, 2012)
"Propranolol treatment was recently reported to be successful for the management of severe infantile hemangioma."7.76Hyperkalemia complicating propranolol treatment of an infantile hemangioma. ( Kietz, S; Lakomek, M; Lauerer, P; Pavlakovic, H; Zutt, M, 2010)
"We describe the occurrence of hyperkalemia in a stable hemodialysis patient who developed digoxin toxicity."7.67Hyperkalemia complicating digoxin toxicity in a patient with renal failure. ( Fraser, C; Papadakis, MA; Sedlacek, SM; Wexman, MP, 1985)
"A case of severe hypertension resistant to multiple drug therapy was controlled with minoxidil, captopril, and propranolol hydrochloride after treatment with these drugs alone or in other combinations had failed."7.66Interaction of minoxidil and captopril in the treatment of refractory hypertension. ( Matson, JR; Norby, LH; Robillard, JE, 1981)
"Propranolol has been widely used in the treatment of infantile hemangiomas since 2008."5.22Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas. ( Chang, L; Chen, H; Hu, L; Huang, H; Jin, Y; Li, W; Lin, X; Ma, G; Qiu, Y; Xu, X; Zhou, B, 2016)
"A 33-day-old female with an ulcerated infantile hemangioma (IH) undergoing oral therapy with propranolol 2 mg/kg per day developed hyperkalemia and hyperphosphatemia 24 h after starting medication."3.78Tumor lysis syndrome after propranolol therapy in ulcerative infantile hemangioma: rare complication or incidental finding? ( Buffon, RB; Cavalli, R; Colli, AM; de Souza, M; Gelmetti, C, 2012)
"Propranolol treatment was recently reported to be successful for the management of severe infantile hemangioma."3.76Hyperkalemia complicating propranolol treatment of an infantile hemangioma. ( Kietz, S; Lakomek, M; Lauerer, P; Pavlakovic, H; Zutt, M, 2010)
" After propranolol, CaCl2 was given during acidosis and hyperkalemia."3.69Role of Ca2+ in protecting the heart from hyperkalemia and acidosis in the rabbit: implications for exercise. ( Leitch, SP; Paterson, DJ, 1994)
"We describe the occurrence of hyperkalemia in a stable hemodialysis patient who developed digoxin toxicity."3.67Hyperkalemia complicating digoxin toxicity in a patient with renal failure. ( Fraser, C; Papadakis, MA; Sedlacek, SM; Wexman, MP, 1985)
"A case of severe hypertension resistant to multiple drug therapy was controlled with minoxidil, captopril, and propranolol hydrochloride after treatment with these drugs alone or in other combinations had failed."3.66Interaction of minoxidil and captopril in the treatment of refractory hypertension. ( Matson, JR; Norby, LH; Robillard, JE, 1981)
"Isoproterenol and propranolol, in a single dose, caused hyperglycemia after 15 and 30 min, either in the conscious rat or in the anesthetized dog."3.65Metabolic responses to catecholamines. ( Aramendía, P; Márquez, MT; Puntoni de Mikulic, LE, 1976)
"Propranolol has been reported to be used as a successful treatment of severe symptomatic infantile haemangiomas."1.40A complication to be aware of: hyperkalaemia following propranolol therapy for an infant with intestinal haemangiomatozis. ( Belen, B; Dalgic, B; Oguz, A; Okur, A, 2014)
"In acute respiratory acidosis, pH-induced plasma potassium elevation is suppressed by simultaneously increased catecholamines, especially epinephrine."1.29[The effect of beta-adrenergic blockade on the plasma potassium elevation induced by acute respiratory acidosis during halothane or fentanyl anesthesia]. ( Amagasa, S; Karube, T; Kato, A; Miura, Y; Sakai, M; Takahashi, T, 1994)
" In potassium loaded, ureter-ligated dogs, heparin increases transmembrane potassium transfer as effectively as does a dosage of atropine large enough to cross the blood-brain barrier and its influence on potassium transfer, like that of atropine, is suppressed by beta-adrenoreceptor blockade."1.28Heparin mediates transmembrane potassium transfer in hyperkalemic dogs. ( Hiatt, JR; Hiatt, N, 1990)
" Treatment of K loaded pancreatectomized dogs with glucagon or a B receptor blockading dosage of propranolol does not alter the proportion transferred, but treatment with glucagon and propranolol reduces it."1.27Kaluresis independent K-homeostasis: glucagon and B receptor blockade in pancreatectomized dogs. ( Chapman, LW; Davidson, MB; Hiatt, N; Mack, H, 1986)
"When hypokalemia was discovered, potassium was administered, resulting in the development of hyperkalemia."1.27Thyrotoxic periodic paralysis. ( Bergeron, L; Sternbach, GL, 1988)
"A case of hyperkalaemic cardiac arrest occurring in a 50-year-old woman after bilateral femoral embolectomies is presented."1.27Hyperkalaemic cardiac arrest following intravenous hydralazine and propranolol therapy post-embolectomy. ( Harrison, L; Hickey, DR; Ramsay, JG; Wynands, JE, 1986)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199025 (67.57)18.7374
1990's6 (16.22)18.2507
2000's1 (2.70)29.6817
2010's5 (13.51)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Belen, B1
Oguz, A1
Okur, A1
Dalgic, B1
Ganigara, A1
Ravishankar, C1
Ramavakoda, C1
Nishtala, M1
Hu, L1
Zhou, B1
Huang, H1
Chang, L1
Qiu, Y1
Ma, G1
Chen, H1
Jin, Y1
Xu, X1
Lin, X1
Li, W1
Pavlakovic, H1
Kietz, S1
Lauerer, P1
Zutt, M1
Lakomek, M1
Cavalli, R1
Buffon, RB1
de Souza, M1
Colli, AM1
Gelmetti, C1
Tassone, H1
Moulin, A1
Henderson, SO1
Rosa, RM1
Silva, P1
Young, JB1
Landsberg, L1
Brown, RS1
Rowe, JW1
Epstein, FH1
Martinez Vea, A1
Montoliu, J1
Andreu, L1
Torras, A1
Gaya, J1
López-Pedret, J1
Revert, L1
Matson, JR1
Norby, LH1
Robillard, JE1
Leitch, SP1
Paterson, DJ2
Takahashi, T1
Kato, A1
Miura, Y1
Karube, T1
Sakai, M1
Amagasa, S1
Allon, M2
Takeshian, A1
Shanklin, N2
Dansby, L1
Bethune, DW1
McKay, R1
Carlsson, E1
Fellenius, E1
Lundborg, P1
Svensson, L1
Hiatt, N3
Chapman, LW2
Davidson, MB2
Dwornikiewicz, W1
Puntoni de Mikulic, LE1
Márquez, MT1
Aramendía, P1
Holland, RP1
Brooks, H1
Pacini, DJ1
Boachie-Ansah, G1
Kane, KA1
Hiatt, JR1
Lehr, D1
Mack, H1
Cox, J1
Starbuck, M1
Nye, PC1
Bergeron, L1
Sternbach, GL1
Hickey, DR1
Harrison, L1
Ramsay, JG1
Wynands, JE1
Kobrin, VI1
Papadakis, MA1
Wexman, MP1
Fraser, C1
Sedlacek, SM1
Guthrie, SD1
Murphy, QR1
Sharma, PL1
Logic, JR1
Lockwood, RH1
Lum, BK1
Lewartowski, B1
Kwiatkowska, B1
Asplund, J1
Edhag, O1
Mogensen, L1
Nyquist, O1
Orinius, E1
Sjögren, A1
Hashimoto, K1
Suzuki, Y1
Chiba, S1
Hayakawa, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Viscous Fiber on Postprandial Kalemic Response in Hemodialysis Patients[NCT05086185]20 participants (Anticipated)Observational2021-06-29Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for propranolol and Hyperkalemia

ArticleYear
The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature.
    The Journal of emergency medicine, 2004, Volume: 26, Issue:2

    Topics: Adult; Anti-Arrhythmia Agents; Emergency Medical Services; Humans; Hyperkalemia; Hyperthyroidism; Hy

2004
[Cellular mechanisms of the etiology of cardiac rhythm disturbances and of the action of basic anti-arrhythmia drugs].
    Kardiologia polska, 1970, Volume: 13, Issue:4

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biological Transport; Biological Transport, Active; Ce

1970

Trials

4 trials available for propranolol and Hyperkalemia

ArticleYear
Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas.
    The Journal of dermatology, 2016, Volume: 43, Issue:10

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Blood Glucose; Body Height; Body Weight; Child; C

2016
Effect of insulin-plus-glucose infusion with or without epinephrine on fasting hyperkalemia.
    Kidney international, 1993, Volume: 43, Issue:1

    Topics: Adult; Blood Glucose; Epinephrine; Fasting; Female; Glucose; Humans; Hyperkalemia; Infusions, Intrav

1993
Glucose modulation of the disposal of an acute potassium load in patients with end-stage renal disease.
    The American journal of medicine, 1993, Volume: 94, Issue:5

    Topics: Adult; Analysis of Variance; Blood Glucose; Female; Glucose; Humans; Hyperkalemia; Insulin; Kidney F

1993
beta-Adrenoceptor blockers, plasma-potassium, and exercise.
    Lancet (London, England), 1978, Aug-19, Volume: 2, Issue:8086

    Topics: Clinical Trials as Topic; Humans; Hyperkalemia; Metoprolol; Physical Exertion; Placebos; Potassium;

1978

Other Studies

31 other studies available for propranolol and Hyperkalemia

ArticleYear
A complication to be aware of: hyperkalaemia following propranolol therapy for an infant with intestinal haemangiomatozis.
    BMJ case reports, 2014, May-19, Volume: 2014

    Topics: Albuterol; Angiography; Biopsy, Needle; Drug Therapy, Combination; Fluid Therapy; Follow-Up Studies;

2014
Fatal hyperkalemia following succinylcholine administration in a child on oral propranolol.
    Drug metabolism and personalized therapy, 2015, Volume: 30, Issue:1

    Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Drug Interactions; Fatal Outcome; Fem

2015
Hyperkalemia complicating propranolol treatment of an infantile hemangioma.
    Pediatrics, 2010, Volume: 126, Issue:6

    Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Albuterol; Female; Fluid Therapy;

2010
Tumor lysis syndrome after propranolol therapy in ulcerative infantile hemangioma: rare complication or incidental finding?
    Dermatology (Basel, Switzerland), 2012, Volume: 224, Issue:2

    Topics: Antineoplastic Agents; Female; Hemangioma, Capillary; Humans; Hyperkalemia; Hyperphosphatemia; Infan

2012
Adrenergic modulation of extrarenal potassium disposal.
    The New England journal of medicine, 1980, Feb-21, Volume: 302, Issue:8

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aldosterone; Catecholamines; Epinephrine; Female; Homeosta

1980
Beta adrenergic modulation of extrarenal potassium disposal in terminal uraemia.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1983, Volume: 19

    Topics: Adrenergic beta-Agonists; Adult; Aged; Epinephrine; Female; Humans; Hyperkalemia; Kidney Failure, Ch

1983
Interaction of minoxidil and captopril in the treatment of refractory hypertension.
    American journal of diseases of children (1960), 1981, Volume: 135, Issue:3

    Topics: Acidosis; Adolescent; Aldosterone; Captopril; Creatinine; Drug Interactions; Female; Humans; Hyperka

1981
Role of Ca2+ in protecting the heart from hyperkalemia and acidosis in the rabbit: implications for exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:5

    Topics: Acidosis; Analysis of Variance; Animals; Calcium; Calcium Chloride; Female; Heart; Hemodynamics; Hyd

1994
[The effect of beta-adrenergic blockade on the plasma potassium elevation induced by acute respiratory acidosis during halothane or fentanyl anesthesia].
    Masui. The Japanese journal of anesthesiology, 1994, Volume: 43, Issue:4

    Topics: Acidosis, Respiratory; Anesthesia, Inhalation; Animals; Dogs; Epinephrine; Fentanyl; Halothane; Hype

1994
Paradoxical changes in serum-potassium during cardiopulmonary bypass in association with non-cardioselective beta blockade.
    Lancet (London, England), 1978, Aug-12, Volume: 2, Issue:8085

    Topics: Cardiopulmonary Bypass; Coronary Vessels; Humans; Hyperkalemia; Oxprenolol; Preoperative Care; Propr

1978
Influence of epinephrine and propranolol on transmembrane K transfer in anuric dogs with hyperkalemia.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:2

    Topics: Animals; Anuria; Cell Membrane; Dogs; Drug Interactions; Epinephrine; Female; Hyperkalemia; Ligation

1979
[Effect of electrolyte imbalance and drugs on the function of artificial pacemakers].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1979, Dec-15, Volume: 32, Issue:24

    Topics: Digitalis Glycosides; Heart; Humans; Hyperkalemia; Pacemaker, Artificial; Propranolol

1979
Metabolic responses to catecholamines.
    Acta physiologica latino americana, 1976, Volume: 26, Issue:4

    Topics: Animals; Catecholamines; Dogs; Drug Interactions; Epinephrine; Hyperglycemia; Hyperkalemia; Hypokale

1976
The QRS complex during myocardial ischemia. An experimental analysis in the porcine heart.
    The Journal of clinical investigation, 1976, Volume: 57, Issue:3

    Topics: Animals; Coronary Disease; Coronary Vessels; Electrocardiography; Extracellular Space; Hyperkalemia;

1976
Modification by hypoxia, hyperkalaemia and acidosis of the cardiac electrophysiological effects of a range of antiarrhythmic drugs.
    British journal of pharmacology, 1992, Volume: 107, Issue:3

    Topics: Acidosis; Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Ele

1992
Heparin mediates transmembrane potassium transfer in hyperkalemic dogs.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1990, Volume: 195, Issue:2

    Topics: Animals; Biological Transport; Cell Membrane; Dogs; Female; Heparin; Hyperkalemia; Male; Phentolamin

1990
Treadmill stress testing under beta-adrenoreceptor blockade.
    The New England journal of medicine, 1985, Mar-28, Volume: 312, Issue:13

    Topics: Adrenergic beta-Antagonists; Exercise Test; Humans; Hyperkalemia; Propranolol

1985
Kaluresis independent K-homeostasis: glucagon and B receptor blockade in pancreatectomized dogs.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1986, Volume: 18, Issue:11

    Topics: Animals; Dogs; Female; Glucagon; Homeostasis; Hyperkalemia; Insulin; Male; Pancreatectomy; Potassium

1986
Hyperkalemic cardiac arrest during an infusion of potassium chloride following an overdose of propranolol.
    Resuscitation, 1986, Volume: 14, Issue:4

    Topics: Adult; Heart Arrest; Humans; Hyperkalemia; Infusions, Parenteral; Male; Potassium Chloride; Proprano

1986
The effect of beta adrenergic blockade on the carotid body response to hyperkalaemia in the cat.
    Respiration physiology, 1988, Volume: 74, Issue:2

    Topics: Animals; Atenolol; Carotid Body; Cats; Dose-Response Relationship, Drug; Hyperkalemia; Hypoxia; Pota

1988
Thyrotoxic periodic paralysis.
    Annals of emergency medicine, 1988, Volume: 17, Issue:8

    Topics: Adult; Humans; Hyperkalemia; Hypokalemia; Male; Methimazole; Paralyses, Familial Periodic; Potassium

1988
Hyperkalaemic cardiac arrest following intravenous hydralazine and propranolol therapy post-embolectomy.
    Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 1

    Topics: Embolism; Female; Heart Arrest; Humans; Hydralazine; Hyperkalemia; Postoperative Complications; Prop

1986
[Prepotentials of cells of the contractile myocardium].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1986, Volume: 72, Issue:5

    Topics: Action Potentials; Animals; Columbidae; Coronary Disease; Electric Stimulation; Female; Guinea Pigs;

1986
Hyperkalemia complicating digoxin toxicity in a patient with renal failure.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1985, Volume: 5, Issue:1

    Topics: Aged; Digoxin; Dose-Response Relationship, Drug; Humans; Hyperkalemia; Kidney Failure, Chronic; Male

1985
Influences of splanchnic blood flow on epinephrine-induced hyperkalemia.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 144, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Blood Flow Velocity; Celiac Artery; Cyclopropanes;

1973
Role of adrenaline-induced hyperkalemia in the genesis of ventricular arrhythmia in dogs under cyclopropane anaesthesia.
    The Indian journal of medical research, 1974, Volume: 62, Issue:11

    Topics: Anesthesia, Inhalation; Animals; Cyclopropanes; Dogs; Epinephrine; Female; Hyperkalemia; Male; Pindo

1974
Experimental effects of anti-arrhythmic drugs on ventricular fibrillation thresholds altered by regional hyperkalemia.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 204, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Dogs; Drug Evaluation, Preclinical; Electrocar

1973
Effects of adrenergic agonists and antagonists on potassium metabolism.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 189, Issue:1

    Topics: Albuterol; Animals; Blood Glucose; Blood Pressure; Butoxamine; Cats; Epinephrine; Ethanolamines; Hea

1974
Four cases of massive digitalis poisoning.
    Acta medica Scandinavica, 1971, Volume: 189, Issue:4

    Topics: Adolescent; Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Coronary Care Units; Di

1971
Effect of potassium excess on pacemaker activity of canine sinoatrial node in vivo.
    The American journal of physiology, 1970, Volume: 218, Issue:1

    Topics: Acetylcholine; Animals; Atrial Fibrillation; Atropine; Blood Pressure; Bradycardia; Dogs; Female; He

1970
Effects of propranolol and some coronary vasodilators on digitalis-induced arrhythmia and hyperkalemia in the dog.
    The Kumamoto medical journal, 1968, Dec-30, Volume: 21, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Digitalis Glycosides; Dogs; Electrocardiography; Guinea Pigs; Heart;

1968