Page last updated: 2024-11-03

propranolol and Hyperglycemia

propranolol has been researched along with Hyperglycemia in 114 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
"To study the involvement of the adrenergic system in nickel-induced hyperglycemia and hepatic glutathione depletion in rats, several adrenergic antagonists (phentolamine, prazosin, yohimbine, and propranolol) were administered in a single ip injection before acute nickel treatment (ip injection)."7.68Alpha 2-adrenergic blockade prevents hyperglycemia and hepatic glutathione depletion in nickel-injected rats. ( Alvarez, C; Bladé, C; Cartañà, J, 1993)
"We previously reported that neostigmine injected into the third cerebral ventricle stimulated adrenal secretion of epinephrine, secretion of glucagon from the pancreas, and direct neural innervation of the liver, resulting in hepatic venous plasma hyperglycemia in anesthetized fed rats."7.68Neostigmine-induced hyperglycemia is mediated by central muscarinic receptor in fed rats. ( Gotoh, M; Iguchi, A; Matsunaga, H; Miura, H; Sakamoto, N; Satake, T; Tamagawa, T; Uemura, K; Yatomi, A, 1990)
"Intracranial injection of D-mannitol (MA) or D-glucose (GL) caused photoperiodic hyperglycemia in rats; MA injection elicited hyperglycemia only in the light period, while GL injection induced it only in the dark period."7.67Role of autonomic nervous system in the time-dependent hyperglycemia induced by intracranial injection of D-mannitol and D-glucose. ( Nagai, K; Nakagawa, H; Yamamoto, H, 1984)
"Diazinon, an organophosphorous compound, produced hyperglycemia and reduced the glycogen content of the brain 2 h after its administration to rats (40 mg/kg, i."7.67Influence of cholinergic and adrenergic blocking drugs on hyperglycemia and brain glycogenolysis in diazinon-treated animals. ( Ansari, RA; Husain, K, 1988)
"Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol."7.66Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy. ( Bouma, DJ; Nardone, DA, 1979)
"Sepsis is accompanied by an enormous increase in catecholamine expression, leading to metabolism of lipids and glucose, changes in cardiovascular output, immunomodulatory effects, and changes in protein metabolism, all of which push the body into a catabolic state."6.44Metabolism modulators in sepsis: propranolol. ( Herndon, DN; Jeschke, MG; Norbury, WB, 2007)
"Pretreatment with propranolol suppressed olanzapine-induced elevations in the serum concentration of glucose, but did not affect the serum concentration of olanzapine or olanzapine-induced increase in the serum concentration of epinephrine."5.43Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine. ( Ishiwata, Y; Nagata, M; Nakajima, M; Negishi, K; Takahashi, H; Takahashi, Y; Yasuhara, M, 2016)
"Carvedilol treatment reversed thyroxin induced hypertriglyceridemia, whereas propranolol treatment had no effect."5.34Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study. ( Bhatt, P; Goyal, R; Makwana, D; Santani, D, 2007)
" We have provided experimental evidence showing the suppressive effects of the nonselective β-adrenoreceptor antagonist propranolol on hyperglycemia, inflammation, and brain injury in a rat model experiencing cerebral ischemia."3.96Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke. ( Chang, CY; Chen, CJ; Chen, WY; Kuan, YH; Liao, SL; Lin, SY; Wang, YY; Wu, CC, 2020)
" Pre-treatment of rats with mifepristone (glucocorticoid receptor antagonist) prevented induction of liver tyrosine aminotransferase activity (TAT), but was ineffective in attenuating hyperglycemia induced by monocrotophos."3.78Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with monocrotophos, an organophosphorus insecticide. ( Joshi, AK; Nagaraju, R; Rajini, PS, 2012)
" Addition of eugenosedin-A to the high-fat diet resulted in less weight gain and reduced hyperglycaemia, hyperinsulinaemia and hyperlipidaemia."3.75Eugenosedin-A prevents hyperglycaemia, hyperlipidaemia and lipid peroxidation in C57BL/6J mice fed a high-fat diet. ( Chen, IJ; Hsieh, SL; Kwan, AL; Lin, HL; Shen, KP; Wu, BN, 2009)
"The effect of adrenoceptor blockers on nicotine induced hyperglycemia were studied in fasted normal and thyroidectomised rats."3.70Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats. ( Fasanmade, AA; Ogwumike, OO, 2000)
" By elevating Epi concentration and/or blocking beta-adrenoreceptors with propranolol (Prop), our goals were to investigate the mechanism for Epi-induced hyperglycemia to determine the possible role played by basal Epi concentration in maintaining resting R(a) glucose and to assess indirect effects of Epi in the intact animal."3.70Regulation of glucose production in rainbow trout: role of epinephrine in vivo and in isolated hepatocytes. ( Shanghavi, DS; Weber, JM, 2000)
"We previously reported that neostigmine injected into the third cerebral ventricle stimulated adrenal secretion of epinephrine, secretion of glucagon from the pancreas, and direct neural innervation of the liver, resulting in hepatic venous plasma hyperglycemia in anesthetized fed rats."3.68Neostigmine-induced hyperglycemia is mediated by central muscarinic receptor in fed rats. ( Gotoh, M; Iguchi, A; Matsunaga, H; Miura, H; Sakamoto, N; Satake, T; Tamagawa, T; Uemura, K; Yatomi, A, 1990)
"To study the involvement of the adrenergic system in nickel-induced hyperglycemia and hepatic glutathione depletion in rats, several adrenergic antagonists (phentolamine, prazosin, yohimbine, and propranolol) were administered in a single ip injection before acute nickel treatment (ip injection)."3.68Alpha 2-adrenergic blockade prevents hyperglycemia and hepatic glutathione depletion in nickel-injected rats. ( Alvarez, C; Bladé, C; Cartañà, J, 1993)
"Intracranial injection of D-mannitol (MA) or D-glucose (GL) caused photoperiodic hyperglycemia in rats; MA injection elicited hyperglycemia only in the light period, while GL injection induced it only in the dark period."3.67Role of autonomic nervous system in the time-dependent hyperglycemia induced by intracranial injection of D-mannitol and D-glucose. ( Nagai, K; Nakagawa, H; Yamamoto, H, 1984)
"Previously we found that in rats, electrical stimulation of the suprachiasmatic nucleus (SCN) of the hypothalamus elicited hyperglycemia associated with hyperglucagonemia without immediate hyperinsulinemia."3.67Involvement of adrenergic mechanism in hyperglycemia due to SCN stimulation. ( Fujii, T; Inoue, S; Nagai, K; Nakagawa, H, 1989)
"Diazinon, an organophosphorous compound, produced hyperglycemia and reduced the glycogen content of the brain 2 h after its administration to rats (40 mg/kg, i."3.67Influence of cholinergic and adrenergic blocking drugs on hyperglycemia and brain glycogenolysis in diazinon-treated animals. ( Ansari, RA; Husain, K, 1988)
"Electrical stimulation of the lateral part of the dorsal parabrachial nucleus (PBD) induces hyperglycemia by enhancing glucagon secretion and suppressing insulin secretion in rats."3.67Hyperglycemia induced by electrical stimulation of lateral part of dorsal parabrachial nucleus. ( Fujiwara, T; Nagai, K; Nakagawa, H; Takagi, S, 1988)
"To determine the mechanism of time-dependent hyperglycemia due to intracranial injection of 2-deoxy-D-glucose (2DG), we examined the effects of various blockers of the autonomic nervous system on the hyperglycemia and hyperglucagonemia induced by intracranial injection of 2DG in male Wistar rats in light and dark periods."3.67Time-dependent involvement of autonomic nervous system in hyperglycemia due to 2-deoxy-D-glucose. ( Nagai, K; Nakagawa, H; Yamamoto, H, 1988)
" The beta-endorphin-induced hyperglycemia was reduced by naloxone (+0."3.67Hypoinsulinemic and hyperglycemic effects of beta-endorphin in rabbits. ( Knudtzon, J, 1986)
" Administration of the beta-adrenergic agonist isoproterenol during the period of insulin resistance (days 26-40 after primary immunization), largely restored fat cell responsiveness to insulin, and eliminated the appearance of fasting hyperglycemia."3.67Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists. ( Cohen, IR; Elias, D; Rapoport, M; Shechter, Y, 1988)
"5-2 mg/kg), chlorpheniramine (1-4 mg/kg) and promethazine (1-4 mg/kg), inhibited dose-dependently the HA-induced hyperglycemia, whereas an H2-receptor antagonist, cimetidine (80 nmol i."3.67Mechanism of the central hyperglycemic action of histamine in mice. ( Itoh, Y; Nishibori, M; Oishi, R; Saeki, K, 1987)
" On the other hand, this hyperglycemia was partially blocked either by the treatment of intact rats with propranolol, beta-adrenergic blocker, or by adrenalectomy."3.66Hyperglycemic effect of hydralazine in rats. ( Hara, S; Kitagawa, H; Satoh, T; Takashima, M, 1980)
"Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol."3.66Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy. ( Bouma, DJ; Nardone, DA, 1979)
" These five groups were then compared on the basis of their insulin response during the oral glucose tolerance test and on the ability of exogenously infused insulin to limit hyperglycemia during a continuous infusion of glucose and insulin, while endogenous insulin was inhibited by the infusion of epinephrine and propranolol."3.65Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? ( Bernstein, R; Davis, B; Olefsky, JM; Reaven, GM, 1976)
"Isoproterenol and propranolol, in a single dose, caused hyperglycemia after 15 and 30 min, either in the conscious rat or in the anesthetized dog."3.65Metabolic responses to catecholamines. ( Aramendía, P; Márquez, MT; Puntoni de Mikulic, LE, 1976)
"The insulin resistance is due to beta-adrenergic stimulation and can be prevented by propranolol."2.66Insulin resistance in type 1 (insulin-dependent) diabetes following hypoglycaemia--evidence for the importance of beta-adrenergic stimulation. ( Attvall, S; Fowelin, J; Lager, I; Smith, U; von Schenck, H, 1987)
"Sepsis is accompanied by an enormous increase in catecholamine expression, leading to metabolism of lipids and glucose, changes in cardiovascular output, immunomodulatory effects, and changes in protein metabolism, all of which push the body into a catabolic state."2.44Metabolism modulators in sepsis: propranolol. ( Herndon, DN; Jeschke, MG; Norbury, WB, 2007)
"Pretreatment with propranolol suppressed olanzapine-induced elevations in the serum concentration of glucose, but did not affect the serum concentration of olanzapine or olanzapine-induced increase in the serum concentration of epinephrine."1.43Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine. ( Ishiwata, Y; Nagata, M; Nakajima, M; Negishi, K; Takahashi, H; Takahashi, Y; Yasuhara, M, 2016)
"Therapeutic potential of agomelatine on neuropathic pain was suppressed with α-methyl-para-tyrosine methyl ester (an inhibitor of catecholamine synthesis), phentolamine (a nonselective α-adrenoceptor antagonist), and propranolol (a nonselective β-adrenoceptor antagonist) administrations."1.43Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms. ( Aydın, TH; Can, ÖD; Demir Özkay, Ü; Turan, N, 2016)
"Carvedilol treatment reversed thyroxin induced hypertriglyceridemia, whereas propranolol treatment had no effect."1.34Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study. ( Bhatt, P; Goyal, R; Makwana, D; Santani, D, 2007)
" 5-CT above the dosage of 0."1.30Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. ( Noma, T; Sugimoto, Y; Yamada, J; Yoshikawa, T, 1998)
" Dose-response curves with epinephrine from lean mice were best fit to a two-component model comprised of 23% high affinity (K(act) = 1."1.29Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. ( Collins, S; Daniel, KW; Gettys, TW; Ramkumar, V; Rohlfs, EM; Taylor, IL, 1994)
" Toxic levels of theophylline were associated with hypokalemia, hypophosphatemia, hyperglycemia, metabolic acidosis, and hypotension in both the patient and the experimental series."1.27Theophylline toxicity and the beta-adrenergic system. ( Curtis, GP; Kearney, TE; Manoguerra, AS; Ziegler, MG, 1985)
"Xylazine was administered intravenously (0."1.26Effect of adrenergic drugs on glucose and plasma glucagon and insulin responses to xylazine in sheep. ( Brockman, RP; Muggaberg, J, 1982)
"Insulin resistance was estimated by measuring the steady-state plasma glucose response to a continuous infusion of insulin, glucose, epinephrine, and propranolol."1.26Locating the site(s) of insulin resistance in patients with nonketotic diabetes mellitus. ( Javorski, C; Kimmerling, G; Olefsky, JM; Reaven, GM, 1976)
"Propranolol pretreatment (5 mg/kg) does not affect the DPH-induced changes in blood glucose, plasma insulin and plasma glucagon."1.26Studies on the hyperglycemic effect of diphenylhydantoin in normal golden hamsters. ( Lefebvre, PJ; Luyckx, AS; Tamburrano, S, 1976)
"Glycogen was depleted only by amphetamine-like compounds or by bemegride-induced convulsions."1.25Physiological and drug-induced changes in the glycogen content of mouse brain. ( Hutchins, DA; Rogers, KJ, 1970)

Research

Studies (114)

TimeframeStudies, this research(%)All Research%
pre-199087 (76.32)18.7374
1990's9 (7.89)18.2507
2000's10 (8.77)29.6817
2010's7 (6.14)24.3611
2020's1 (0.88)2.80

Authors

AuthorsStudies
Lin, SY1
Wang, YY1
Chang, CY1
Wu, CC1
Chen, WY1
Kuan, YH1
Liao, SL1
Chen, CJ1
Kayano, R1
Morofuji, Y1
Nakagawa, S1
Fukuda, S1
Watanabe, D1
Ozawa, H1
Niwa, M2
Matsuo, T1
Shepherd, SJ1
Newman, R1
Brett, SJ1
Griffith, DM1
Nagata, M1
Nakajima, M1
Ishiwata, Y1
Takahashi, Y1
Takahashi, H1
Negishi, K1
Yasuhara, M1
Aydın, TH1
Can, ÖD1
Demir Özkay, Ü1
Turan, N1
Shen, KP1
Lin, HL1
Hsieh, SL1
Kwan, AL1
Chen, IJ1
Wu, BN1
Salahdeen, HM1
Alada, AR3
Wintergerst, KA1
Rogers, ES1
Foster, MB1
Joshi, AK1
Nagaraju, R1
Rajini, PS1
Ruohonen, ST1
Ruohonen, S1
Gilsbach, R1
Savontaus, E1
Scheinin, M1
Hein, L1
Ekhelar, AI1
Oyebola, OD1
Park, C1
Yang, I1
Woo, J1
Kim, S1
Kim, J1
Kim, Y1
Park, S1
Bhatt, P1
Makwana, D1
Santani, D1
Goyal, R1
Norbury, WB1
Jeschke, MG1
Herndon, DN1
Salvador, RA1
April, SA1
Lemberger, L1
Opie, LH1
Acheson, K1
Jéquier, E2
Wahren, J1
Cryer, PE4
Tse, TF1
Clutter, WE1
Shah, SD1
Yamamoto, H2
Nagai, K5
Nakagawa, H4
Rizza, RA2
Haymond, MW2
Gerich, JE4
Satoh, T1
Hara, S1
Takashima, M1
Kitagawa, H1
Johansson, SR1
Andersson, RG1
Ribes, G1
Blayac, JP1
Loubatieres-Mariani, MM1
Goldstein, RA1
Mullani, NA1
Marani, SK1
Fisher, DJ1
Gould, KL1
O'Brien, HA1
Muggaberg, J1
Brockman, RP1
Miles, JM1
Verdonk, CA1
Chevaux, F1
Shapiro, AP1
Traub, YM1
Nonogaki, K1
Iguchi, A3
Sakamoto, N3
Oyebola, DD1
Collins, S1
Daniel, KW1
Rohlfs, EM1
Ramkumar, V1
Taylor, IL1
Gettys, TW1
Alvarez, C1
Bladé, C1
Cartañà, J1
Yamada, J2
Sugimoto, Y2
Noma, T1
Yoshikawa, T2
Weber, JM1
Shanghavi, DS1
Rashid, S1
Shi, ZQ1
Mathoo, JM1
Vandelangeryt, ML1
Bilinski, D1
Lewis, GF1
Vranic, M1
Ogwumike, OO1
Fasanmade, AA1
Gürün, MS1
Ilçöl, YO1
Taga, Y1
Ulus, IH1
Bouvenot, G1
Escande, M1
Jouve, R1
Delboy, C1
Bercher, H1
Grisk, A1
Dehaye, JP1
Winand, J1
Christophe, J1
Lager, I2
Blohmé, G1
Smith, U2
McCloy, RF1
Dawson, VA1
Baron, JH1
Inglis, RJ1
Clissiounis, N1
Reaven, GM6
Nardone, DA1
Bouma, DJ1
Koch-Weser, J1
Bernstein, R1
Davis, B1
Olefsky, JM3
Kimmerling, G2
Javorski, C1
Frohman, LA2
Puntoni de Mikulic, LE1
Márquez, MT1
Aramendía, P1
Lorenzi, M1
Tsalikian, E1
Karam, JH1
Ginsberg, H1
Skikama, H1
Ui, M1
Holland, OB1
Kaplan, NM1
Tamburrano, S1
Luyckx, AS1
Lefebvre, PJ1
Foss, A1
Ahrén, B2
Albertini, R1
Vargas, L1
Yatomi, A1
Gotoh, M2
Matsunaga, H2
Uemura, K1
Miura, H1
Satake, T1
Tamagawa, T1
Fujii, T1
Inoue, S1
Yü, CC1
Hua, HA1
Tong, C1
Attvall, S1
Fowelin, J1
von Schenck, H1
Moratinos, J1
Carpene, C1
de Pablos, I1
Reverte, M1
Husain, K1
Ansari, RA1
Dornhorst, A1
Powell, SH1
Pensky, J1
Marubashi, S1
Tominaga, M1
Katagiri, T1
Yamatani, K1
Yawata, Y1
Hara, M1
Sasaki, H1
Campbell, PJ1
Bolli, GB1
Ohuchi, M1
Nomura, T1
Fujiwara, T1
Takagi, S1
Brunicardi, FC1
Druck, P1
Seymour, NE1
Sun, YS1
Gingerich, RL1
Elahi, D1
Andersen, DK1
Knudtzon, J1
Kearney, TE1
Manoguerra, AS1
Curtis, GP1
Ziegler, MG1
Beylot, M1
Sautot, G1
Dechaud, H1
Cohen, R1
Riou, JP1
Serusclat, P1
Mornex, R1
Lindskog, S1
Tatemoto, K1
Efendić, S1
Elias, D1
Rapoport, M1
Cohen, IR1
Shechter, Y1
Nishibori, M1
Itoh, Y1
Oishi, R1
Saeki, K1
Keller, R1
Beeger, I1
Berlan, M1
Baïsset, MA1
Agid, MR1
Antonis, A1
Clark, ML1
Hodge, RL1
Molony, M1
Pilkington, TR1
Pinter, EJ1
Pattee, CJ1
Peterfy, G1
Cleghorn, JM1
Reveno, WS1
Rosenbaum, H1
Opitz, K1
Chu, H1
Cronholm, LS1
Fishel, CW1
Nakamura, Y1
Takemura, Y1
Yamada, T1
Baïsset, A1
Dang-Tran, L1
Montastruc, P1
Jori, A1
Carrara, MC1
Sato, T1
Wagner, J1
Mennear, JH1
Spratto, GR1
Miya, TS1
Duyckaerts, C1
Atkins, T1
Matty, AJ1
Kokka, N1
Eisenberg, RM1
Garcia, J1
George, R1
Nash, CB1
Smith, RD1
Perrier, H1
Perrier, C1
Gras, J1
Gothelf, B1
Ellis, S1
Khosla, P1
Garg, KN1
Cerchio, GM1
Persico, PA1
Müller, EE1
Cocchi, D1
Olefsky, J1
Farquhar, JW2
Reaven, G1
Swenson, RS1
Peterson, DT1
Eshleman, M1
Timsit, J1
Giroud, JP1
Dechezleprĕtre, S1
Lechat, P1
Kersh, ES1
Schwartz, LK1
Mendizabal, EM1
Steinbock, MW1
Sapira, JD1
Avruskin, TW1
Tang, SC1
Juan, CS1
Oneda, A1
Adnitt, PI1
Hutchins, DA1
Rogers, KJ1
Massara, F1
Strumia, E1
Walfish, PG1
Natale, R1
Chang, C1
Shen, SW1
Vinik, A1
Pimstone, B1
Buchanan-Lee, B1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by the Funny Channel Current (If) Inhibitor Ivabradine"[NCT01186783]Phase 270 participants (Anticipated)Interventional2010-05-31Recruiting
Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling[NCT02437084]Phase 4115 participants (Actual)Interventional2015-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Fasting Plasma Glucose

Baseline and end-of-treatment fasting plasma glucose (mg/dL) values represent average of up to 3 measurements for each value (obtained at baseline weeks -2, -1, and 0 and at the end of study at weeks 8, 9, and 10). (NCT02437084)
Timeframe: 10 weeks

Interventionmg/dL (Median)
BaselineEnd of Study
Individuals Without Diabetes Eligible to Receive Statin Therapy99100

Fasting Plasma Insulin

Baseline and end-of-treatment fasting plasma insulin (mU/L) values represent average of up to 3 measurements for each value (obtained at baseline weeks -2, -1, and 0 and at the end of study at weeks 8, 9, and 10). (NCT02437084)
Timeframe: 10 weeks

InterventionmU/L (Median)
BaselineEnd of Study
Individuals Without Diabetes Eligible to Receive Statin Therapy10.110.6

Insulin Secretion Rate Area Under the Curve (ISR-AUC)

Insulin secretion measured by ISR-AUC (pmol/min x 4 h) during the graded glucose infusion test. (NCT02437084)
Timeframe: baseline, week 9 or 10

Interventionpmol/min x 4 h (Median)
BaselineEnd of Study
Individuals Without Diabetes Eligible to Receive Statin Therapy18241942

OGTT Glucose AUC

Glucose area under the curve (AUC) (mg/dL x 2 h) measured during a 75-gram oral glucose tolerance test (OGTT). (NCT02437084)
Timeframe: baseline, week 8

Interventionmg/dL x 2 h (Median)
BaselineEnd of Study
Individuals Without Diabetes Eligible to Receive Statin Therapy295299

OGTT Insulin AUC

Insulin area under the curve (AUC) (mU/L x 2h) measured during a 75-gram oral glucose tolerance test (OGTT). (NCT02437084)
Timeframe: baseline, week 8

InterventionmU/L x 2 h (Median)
BaselineEnd of Study
Individuals Without Diabetes Eligible to Receive Statin Therapy127133

Steady-state Plasma Glucose (SSPG)

Insulin sensitivity measured by SSPG concentration (mg/dL) during the insulin suppression test. (NCT02437084)
Timeframe: baseline, week 9 or 10

Interventionmg/dL (Median)
BaselineEnd of Study
Individuals Without Diabetes Eligible to Receive Statin Therapy130139

Reviews

7 reviews available for propranolol and Hyperglycemia

ArticleYear
Pharmacological Therapy for the Prevention and Treatment of Weakness After Critical Illness: A Systematic Review.
    Critical care medicine, 2016, Volume: 44, Issue:6

    Topics: Adrenergic beta-Antagonists; Anabolic Agents; Critical Illness; Glutamine; Growth Hormone; Humans; H

2016
Metabolism modulators in sepsis: propranolol.
    Critical care medicine, 2007, Volume: 35, Issue:9 Suppl

    Topics: Adrenergic beta-Antagonists; Cytokines; Energy Metabolism; Humans; Hyperglycemia; Lipolysis; Propran

2007
Myocardial infarct size. Part 2. Comparison of anti-infarct effects of beta-blockade, glucose-insulin-potassium, nitrates, and hyaluronidase.
    American heart journal, 1980, Volume: 100, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Glucose; Heart Rate; Heparin; Humans; Hyaluron

1980
Diazoxide.
    The New England journal of medicine, 1976, Jun-03, Volume: 294, Issue:23

    Topics: Blood Pressure; Cardiac Output; Diazoxide; Diuretics; Drug Synergism; Emergencies; Female; Half-Life

1976
Is the basic lesion in diabetes insulin deficiency or insulin resistance?
    Nutrition reviews, 1976, Volume: 34, Issue:11

    Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Epinephrine; Glucose; Humans; Hyperglycemi

1976
[Contribution to the pharmacology of the beta-adrenolytics].
    Deutsche medizinische Wochenschrift (1946), 1970, Nov-27, Volume: 95, Issue:48

    Topics: Adrenergic beta-Antagonists; Anesthesia, Local; Animals; Arousal; Arrhythmias, Cardiac; Asthma; Card

1970
[Growth hormone and carbohydrate metabolism].
    Horumon to rinsho. Clinical endocrinology, 1971, Volume: 19, Issue:8

    Topics: Acromegaly; Animals; Carbohydrate Metabolism; Diabetes Mellitus; Dogs; Glucagon; Growth Hormone; Hum

1971

Trials

4 trials available for propranolol and Hyperglycemia

ArticleYear
Acute hyperglycemia and activation of the beta-adrenergic system exhibit synergistic inhibitory actions on growth hormone (GH) releasing hormone-induced GH release.
    European journal of endocrinology, 2003, Volume: 148, Issue:6

    Topics: Acute Disease; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Drug Synergism; Growth

2003
Effect of cardioselective and non-selective beta-blockade on the hypoglycaemic response in insulin-dependent diabetics.
    Lancet (London, England), 1979, Mar-03, Volume: 1, Issue:8114

    Topics: Adult; Blood Glucose; Blood Pressure; Bradycardia; Clinical Trials as Topic; Diabetes Mellitus; Dias

1979
Insulin resistance in type 1 (insulin-dependent) diabetes following hypoglycaemia--evidence for the importance of beta-adrenergic stimulation.
    Diabetologia, 1987, Volume: 30, Issue:9

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Heart Rate; Humans; Hyperglycemia; Hypoglyc

1987
Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion.
    Lancet (London, England), 1985, Jan-19, Volume: 1, Issue:8421

    Topics: Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug Synergism; Drug Thera

1985

Other Studies

103 other studies available for propranolol and Hyperglycemia

ArticleYear
Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke.
    Cells, 2020, 06-01, Volume: 9, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Brain Injuries; Cell Line; Cytokines; Disease Models, Animal;

2020
In vitro analysis of drugs that improve hyperglycemia-induced blood-brain barrier dysfunction.
    Biochemical and biophysical research communications, 2018, 09-10, Volume: 503, Issue:3

    Topics: Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Cilostazol; Disease Models, Animal

2018
Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:5

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Corticosterone; Epinephrine; Glucagon

2016
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms.
    Fundamental & clinical pharmacology, 2016, Volume: 30, Issue:6

    Topics: Acetamides; Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Diabetic Neurop

2016
Eugenosedin-A prevents hyperglycaemia, hyperlipidaemia and lipid peroxidation in C57BL/6J mice fed a high-fat diet.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:4

    Topics: Adipose Tissue; Animals; Atorvastatin; Blood Glucose; Body Weight; Brain; Dietary Fats; Female; Glut

2009
Role of adrenergic receptors in the caffeine-induced increase in glucose uptake by the canine hindlimb.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2009, Volume: 24, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Biological Transport; Blood Gluc

2009
Hyperthyroidism presenting with hyperglycemia in an adolescent female.
    Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:5-6

    Topics: Adolescent; Adrenergic beta-Antagonists; Antithyroid Agents; Blood Glucose; Female; Graves Disease;

2011
Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with monocrotophos, an organophosphorus insecticide.
    Toxicology, 2012, Mar-29, Volume: 294, Issue:1

    Topics: Animals; Atropine; Blood Glucose; Corticosterone; Enzyme Induction; Epinephrine; Hyperglycemia; Inse

2012
Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia.
    Neuroendocrinology, 2012, Volume: 96, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals

2012
Effect of adrenaline on the glucose uptake by the canine hindlimb.
    African journal of medicine and medical sciences, 2002, Volume: 31, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood

2002
Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study.
    Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Appetite; Blood Glucose; Blood Pressure; Body Mass Index; Body

2007
Inhibition by butoxamine, propranolol and MJ1999 of the glycogenolytic action of the catecholamines in the rat.
    Biochemical pharmacology, 1967, Volume: 16, Issue:10

    Topics: Animals; Butylamines; Catecholamines; Epinephrine; Fasting; Glycogen; Hyperglycemia; Isoproterenol;

1967
Influence of beta-adrenergic blockade on glucose-induced thermogenesis in man.
    The Journal of clinical investigation, 1983, Volume: 72, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Basal Metabolism; Body Temperature Regulation; Energy Metabolism

1983
Roles of glucagon and epinephrine in hypoglycemic and nonhypoglycemic glucose counterregulation in humans.
    The American journal of physiology, 1984, Volume: 247, Issue:2 Pt 1

    Topics: Adrenalectomy; Blood Glucose; Epinephrine; Glucagon; Growth Hormone; Humans; Hyperglycemia; Hypoglyc

1984
Role of autonomic nervous system in the time-dependent hyperglycemia induced by intracranial injection of D-mannitol and D-glucose.
    Chronobiology international, 1984, Volume: 1, Issue:1

    Topics: Animals; Atropine; Autonomic Nervous System; Circadian Rhythm; Darkness; Glucose; Hexamethonium; Hex

1984
Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man.
    The Journal of clinical investigation, 1980, Volume: 65, Issue:3

    Topics: Adult; Blood Glucose; Epinephrine; Glucagon; Humans; Hyperglycemia; Insulin; Male; Phentolamine; Pro

1980
Hyperglycemic effect of hydralazine in rats.
    Journal of pharmacobio-dynamics, 1980, Volume: 3, Issue:8

    Topics: Adrenal Glands; Animals; Cyclic AMP; Female; Glycogen; Hydralazine; Hyperglycemia; Male; Phentolamin

1980
Decrease of some metabolic and physiologic effects of diazoxide by propranolol in rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1981, Volume: 316, Issue:2

    Topics: Animals; Blood Pressure; Cyclic AMP; Diazoxide; Drug Interactions; Female; Hyperglycemia; Liver; Pro

1981
Differences between the effects of adrenaline and noradrenaline on insulin secretion in the dog.
    Diabetologia, 1983, Volume: 24, Issue:2

    Topics: Animals; Blood Glucose; Blood Pressure; Dogs; Duodenum; Epinephrine; Hyperglycemia; Insulin; Insulin

1983
Myocardial perfusion with rubidium-82. II. Effects of metabolic and pharmacologic interventions.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1983, Volume: 24, Issue:10

    Topics: Animals; Coronary Circulation; Digoxin; Dogs; Heart; Hydrogen-Ion Concentration; Hyperglycemia; Meth

1983
Effect of adrenergic drugs on glucose and plasma glucagon and insulin responses to xylazine in sheep.
    Research in veterinary science, 1982, Volume: 33, Issue:1

    Topics: Animals; Blood Glucose; Glucagon; Hyperglycemia; Insulin; Phentolamine; Propranolol; Sheep; Sheep Di

1982
Effect of alpha-adrenergic stimulation and its blockade on glucose turnover in man.
    The American journal of physiology, 1980, Volume: 238, Issue:5

    Topics: Adult; Blood Glucose; Epinephrine; Female; Glucagon; Humans; Hyperglycemia; Insulin; Male; Phentolam

1980
Influence of plasma glucose and insulin concentrations on carbohydrate oxidation in man.
    Diabete & metabolisme, 1982, Volume: 8, Issue:2

    Topics: Adult; Blood Glucose; Carbohydrate Metabolism; Epinephrine; Female; Glucose; Humans; Hyperglycemia;

1982
Complications of antihypertensive therapy.
    American family physician, 1981, Volume: 23, Issue:3

    Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydr

1981
Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha in rats.
    European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Body Temperature; Dinoprost; Fever; Hyperglyce

1994
Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat.
    African journal of medicine and medical sciences, 1993, Volume: 22, Issue:4

    Topics: Animals; Blood Glucose; Disease Models, Animal; Dogs; Epinephrine; Hyperglycemia; Male; Nicotine; Pr

1993
Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice.
    Molecular endocrinology (Baltimore, Md.), 1994, Volume: 8, Issue:4

    Topics: Adenylyl Cyclases; Adipose Tissue; Adipose Tissue, Brown; Adrenergic beta-Agonists; Adrenergic beta-

1994
Alpha 2-adrenergic blockade prevents hyperglycemia and hepatic glutathione depletion in nickel-injected rats.
    Toxicology and applied pharmacology, 1993, Volume: 121, Issue:1

    Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Female; Glucagon; Glutathione; Hypergly

1993
Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.
    European journal of pharmacology, 1998, Oct-16, Volume: 359, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Glucose; Glucagon; Hyperglycemia; Insulin; Ma

1998
p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors.
    European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3

    Topics: 4-Aminobenzoic Acid; Adrenal Medulla; Adrenalectomy; Aminopyridines; Animals; Blood Glucose; Dose-Re

1998
Regulation of glucose production in rainbow trout: role of epinephrine in vivo and in isolated hepatocytes.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:4

    Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Cell Fractionation; Cells, Cultured; Dose

2000
Beta-blockade, but not normoglycemia or hyperinsulinemia, markedly diminishes stress-induced hyperglycemia in diabetic dogs.
    Diabetes, 2000, Volume: 49, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Blood Glucose; Carbachol; Diabetes Mellitus, Experimental; Dog

2000
Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats.
    African journal of medicine and medical sciences, 2000, Volume: 29, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Disease Models, A

2000
Hyperglycemia induced by intracerebroventricular choline: involvement of the sympatho-adrenal system.
    European journal of pharmacology, 2002, Mar-08, Volume: 438, Issue:3

    Topics: Adrenal Glands; Adrenalectomy; Animals; Atropine; Blood Glucose; Choline; Cholinergic Agents; Dose-R

2002
[Beta blockaders and general pathology].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1977, Mar-09, Volume: 53, Issue:10

    Topics: Acebutolol; Adrenergic beta-Antagonists; Asthma; Female; Humans; Hypercalcemia; Hyperglycemia; Hypog

1977
[The effect of fluoridated phenylethanolamines on hyperglycemia induced by catecholamines in the rat].
    Acta biologica et medica Germanica, 1975, Volume: 34, Issue:4

    Topics: Animals; Catecholamines; Drug Antagonism; Epinephrine; Ethanolamines; Female; Hyperglycemia; Isoprot

1975
Effect of lipolytic agents on calcium uptake in the epididymal adipose tissue of obese-hyperglycemic mice and their lean controls [proceedings].
    Archives internationales de physiologie et de biochimie, 1977, Volume: 85, Issue:2

    Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Bucladesine; Calcium; Epinephrine; Glucagon; H

1977
The effect of salbutamol and propranolol on pentagastrin, histamine and meal-stimulated acid and pepsin secretion in the dog.
    Acta hepato-gastroenterologica, 1979, Volume: 26, Issue:5

    Topics: Albuterol; Animals; Blood Glucose; Dogs; Dose-Response Relationship, Drug; Gastric Fistula; Gastric

1979
Maturity-onset diabetes.
    British medical journal, 1979, Jun-30, Volume: 1, Issue:6180

    Topics: Diabetes Mellitus; Humans; Hyperglycemia; Male; Propranolol

1979
Effect of adrenergic drugs on morphine-induced hyperglycemia.
    Life sciences, 1979, Jul-23, Volume: 25, Issue:4

    Topics: Animals; Dihydroergotoxine; Female; Hyperglycemia; Iproniazid; Male; Monoamine Oxidase Inhibitors; M

1979
Insulin resistance and insulin secretion in patients with chemical diabetes: implications concerning the pathogenesis of idiopathic diabetes mellitus.
    Advances in experimental medicine and biology, 1979, Volume: 119

    Topics: Blood Glucose; Diabetes Mellitus; Epinephrine; Fasting; Glucose Tolerance Test; Humans; Hyperglycemi

1979
Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.
    Southern medical journal, 1979, Volume: 72, Issue:12

    Topics: Diabetic Coma; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hyperglycemia; Hyp

1979
Nonketotic diabetes mellitus: insulin deficiency or insulin resistance?
    The American journal of medicine, 1976, Volume: 60, Issue:1

    Topics: Adult; Diabetes Mellitus; Diabetic Ketoacidosis; Epinephrine; Female; Glucose Tolerance Test; Humans

1976
Locating the site(s) of insulin resistance in patients with nonketotic diabetes mellitus.
    Diabetes, 1976, Volume: 25, Issue:8

    Topics: Adult; Diabetes Mellitus; Epinephrine; Fasting; Glucose; Glucose Tolerance Test; Homeostasis; Humans

1976
Hyperglycemia and hyperglucagonemia following neurotensin administration.
    Life sciences, 1976, Jul-15, Volume: 19, Issue:2

    Topics: Adrenal Medulla; Animals; Dose-Response Relationship, Drug; Glucagon; Hyperglycemia; Hypothalamus; I

1976
Metabolic responses to catecholamines.
    Acta physiologica latino americana, 1976, Volume: 26, Issue:4

    Topics: Animals; Catecholamines; Dogs; Drug Interactions; Epinephrine; Hyperglycemia; Hyperkalemia; Hypokale

1976
Studies on the mechanism of epinephrine-induced hyperglycemia in man. Evidence for participation of pancreatic glucagon secretion.
    Diabetes, 1976, Volume: 25, Issue:1

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Drug Synergism; Epinephrine; Fatty Acids, Nonesteri

1976
Demonstration of insulin resistance in untreated adult onset diabetic subjects with fasting hyperglycemia.
    The Journal of clinical investigation, 1975, Volume: 55, Issue:3

    Topics: Adult; Aged; Chronic Disease; Diabetes Complications; Diabetes Mellitus; Epinephrine; Fasting; Femal

1975
Adrenergic receptor and epinephrine-induced hyperglycemia and glucose tolerance.
    The American journal of physiology, 1975, Volume: 229, Issue:4

    Topics: Animals; Bicarbonates; Blood Glucose; Carbon Radioisotopes; Epinephrine; Glucose; Hyperglycemia; Ind

1975
Propranolol in the treatment of hypertension.
    The New England journal of medicine, 1976, Apr-22, Volume: 294, Issue:17

    Topics: Arrhythmias, Cardiac; Brain; Bronchial Spasm; Depression, Chemical; Diuretics; Drug Synergism; Heart

1976
Studies on the hyperglycemic effect of diphenylhydantoin in normal golden hamsters.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1976, Volume: Suppl 6

    Topics: Animals; Blood Glucose; Cricetinae; Glucagon; Hyperglycemia; Insulin; Male; Phentolamine; Phenytoin;

1976
Insulin secretion and sensitivity after partial hepatectomy in the rat.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1991, Volume: 191, Issue:4

    Topics: Animals; Blood Glucose; Epinephrine; Glucose; Hepatectomy; Hyperglycemia; Insulin; Insulin Resistanc

1991
Intravesical catheterization through the urethra induces stress hyperglycemia in conscious rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1990, Volume: 22, Issue:8

    Topics: Adrenal Medulla; Adrenergic beta-Antagonists; Animals; Female; Hyperglycemia; Injections, Intraventr

1990
Neostigmine-induced hyperglycemia is mediated by central muscarinic receptor in fed rats.
    Brain research, 1990, Jan-22, Volume: 507, Issue:2

    Topics: Adrenergic Fibers; Animals; Atropine; Brain; Hyperglycemia; Injections, Intraventricular; Male; Neos

1990
Involvement of adrenergic mechanism in hyperglycemia due to SCN stimulation.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1989, Volume: 21, Issue:12

    Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System; Electric Stimulation; Female; Gluca

1989
Hyperglycaemia after burn injury.
    Burns : journal of the International Society for Burn Injuries, 1989, Volume: 15, Issue:3

    Topics: Adrenalectomy; Animals; Burns; Glucose Tolerance Test; Hyperglycemia; Insulin; Male; Phentolamine; P

1989
Role of alpha 1- and alpha 2-adrenoceptors in catecholamine-induced hyperglycaemia, lipolysis and insulin secretion in conscious fasted rabbits.
    British journal of pharmacology, 1988, Volume: 94, Issue:2

    Topics: Animals; Catecholamines; Clonidine; Hyperglycemia; Insulin; Insulin Secretion; Lipolysis; Male; Praz

1988
Influence of cholinergic and adrenergic blocking drugs on hyperglycemia and brain glycogenolysis in diazinon-treated animals.
    Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:9

    Topics: Animals; Atropine; Brain; Diazinon; Female; Glucose-6-Phosphatase; Glycogen; Hyperglycemia; Insectic

1988
Hyperglycaemic effect of glucagon administered intracerebroventricularly in the rat.
    Acta endocrinologica, 1985, Volume: 108, Issue:1

    Topics: Adrenalectomy; Animals; Atropine; Autonomic Nervous System; Blood Glucose; Glucagon; Hexamethonium;

1985
Pathogenesis of the dawn phenomenon in patients with insulin-dependent diabetes mellitus. Accelerated glucose production and impaired glucose utilization due to nocturnal surges in growth hormone secretion.
    The New England journal of medicine, 1985, Jun-06, Volume: 312, Issue:23

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Glucagon; Growth Hormone; Humans; Hype

1985
Increase in plasma glucose concentration after intracerebroventricular injection of N,O'-dibutyryl cyclic adenosine 3',5'-monophosphate.
    Endocrinology, 1986, Volume: 119, Issue:1

    Topics: Adenosine Triphosphate; Animals; Atropine; Blood Glucose; Bucladesine; Cyclic AMP; Dibutyryl Cyclic

1986
Hyperglycemia induced by electrical stimulation of lateral part of dorsal parabrachial nucleus.
    The American journal of physiology, 1988, Volume: 254, Issue:4 Pt 1

    Topics: Animals; Atropine; Blood Glucose; Electric Stimulation; Female; Glucagon; Hexamethonium; Hexamethoni

1988
Time-dependent involvement of autonomic nervous system in hyperglycemia due to 2-deoxy-D-glucose.
    The American journal of physiology, 1988, Volume: 255, Issue:6 Pt 1

    Topics: Animals; Atropine; Autonomic Nervous System; Blood Glucose; Circadian Rhythm; Deoxyglucose; Glucagon

1988
Splanchnic neural regulation of pancreatic polypeptide release in the isolated perfused human pancreas.
    American journal of surgery, 1989, Volume: 157, Issue:1

    Topics: Adolescent; Adult; Aged; Cholinergic Fibers; Electric Stimulation; Female; Humans; Hyperglycemia; Ma

1989
Hypoinsulinemic and hyperglycemic effects of beta-endorphin in rabbits.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1986, Volume: 18, Issue:8

    Topics: Animals; Atropine; beta-Endorphin; Blood Glucose; Endorphins; Female; Glucagon; Hyperglycemia; Injec

1986
Theophylline toxicity and the beta-adrenergic system.
    Annals of internal medicine, 1985, Volume: 102, Issue:6

    Topics: Acidosis; Adolescent; Aminophylline; Animals; Catecholamines; Disease Models, Animal; Dogs; Female;

1985
Lack of beta-adrenergic role for catecholamines in the development of hyperglycemia and ketonaemia following acute insulin withdrawal in type I diabetic patients.
    Diabete & metabolisme, 1985, Volume: 11, Issue:2

    Topics: Adult; Catecholamines; Diabetes Mellitus, Type 1; Epinephrine; Fatty Acids, Nonesterified; Glucagon;

1985
Pancreastatin inhibits insulin secretion and stimulates glucagon secretion in mice.
    Diabetes, 1988, Volume: 37, Issue:3

    Topics: Animals; Blood Glucose; Carbachol; Chromogranin A; Female; Glucagon; Glucose; Hyperglycemia; Insulin

1988
Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists.
    The Journal of clinical investigation, 1988, Volume: 81, Issue:6

    Topics: Adipose Tissue; Aminophylline; Animals; Fasting; Hyperglycemia; Immunoglobulin Idiotypes; Insulin; I

1988
Mechanism of the central hyperglycemic action of histamine in mice.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Adrenalectomy; Animals; Blood Glucose; Chlorpheniramine; Chromatography, High Pressure Liquid; Corti

1987
Increase in the sensitivity of the rat to histamine following injection with Nippostrongylus brasiliensis.
    International archives of allergy and applied immunology, 1971, Volume: 41, Issue:2

    Topics: Allergens; Animals; Blood Glucose; Cortisone; Drug Hypersensitivity; Epinephrine; Histamine; Histami

1971
[Effect of fasting and hypophysectomy on the lipolytic and hyperglycemic action of adrenaline in dogs treated with beta blockaders].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1974, Volume: 168, Issue:1

    Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animals; Blood Glucose; Dogs; Drug Interac

1974
Receptor mechanisms in the hyperglycaemic response to adrenaline in man.
    Lancet (London, England), 1967, May-27, Volume: 1, Issue:7500

    Topics: Drug Synergism; Epinephrine; Gluconeogenesis; Humans; Hyperglycemia; Lactates; Phentolamine; Propran

1967
Metabolic effects of autonomic blockade.
    Lancet (London, England), 1967, Jul-08, Volume: 2, Issue:7506

    Topics: Blood Glucose; Fatty Acids; Humans; Hyperglycemia; Hypoglycemia; Metabolism; Nicotinic Acids; Phenox

1967
Propranolol and hypoglycaemia.
    Lancet (London, England), 1968, Apr-27, Volume: 1, Issue:7548

    Topics: Adult; Diabetes Mellitus; Female; Humans; Hyperglycemia; Hypoglycemia; Insulin; Male; Middle Aged; P

1968
[A study of the calorigenic action of catecholamines].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 259, Issue:4

    Topics: Adipose Tissue; Animals; Desipramine; Epinephrine; Fatty Acids, Nonesterified; Hyperglycemia; Hypoli

1968
Bordetella pertussis-induced alteration of the normal hyperglycemic response of mice to 3',5'-adenosine phosphate.
    Journal of bacteriology, 1968, Volume: 95, Issue:6

    Topics: Adenine Nucleotides; Animals; Blood Glucose; Bordetella pertussis; Cyclic AMP; Dibenzylchlorethamine

1968
Inhibitory effect of propranolol on hyperglycemia induced by dibutyryl 3',5'-cyclic AMP.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 139, Issue:2

    Topics: Animals; Blood Glucose; Butyrates; Cyclic AMP; Drug Antagonism; Hyperglycemia; Liver; Male; Phosphor

1972
[Effect of an adrenergic beta-blocking agent on adrenaline-induced hyperglycemia in hypophysectomized dogs].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1971, Volume: 165, Issue:11

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Animals; Blood Glucose; Dogs; Epinephrine; Hyperglycemia

1971
On the mechanism of the hyperglycaemic effect of chlorpromazine.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:9

    Topics: Animals; Blood Glucose; Chlorpromazine; Drug Synergism; Epinephrine; Ethanolamines; Hyperglycemia; N

1966
Glycemic effects of solanine in rats.
    Japanese journal of pharmacology, 1967, Volume: 17, Issue:4

    Topics: Adrenalectomy; Animals; Blood Glucose; Chlorpromazine; Ergotamine; Female; Glucose Tolerance Test; G

1967
Failure of beta-adrenergic blocking agents to antagonize the hyperglycemic effect of epinephrine in mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1971, Volume: 137, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Adrenergic beta-Antagonists; Animals; Chlorpromazine; Epinephrine; Hy

1971
[Role of catecholamines in hypoxia and hyperglycemia induced by injection of cystamine].
    Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 191, Issue:2

    Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose;

1971
[Six years' experience with a musculoplastic technic].
    The Journal of endocrinology, 1971, Volume: 51, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists

1971
Blood glucose, growth hormone, and cortisol levels after hypothalamic stimulation.
    The American journal of physiology, 1972, Volume: 222, Issue:2

    Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animals; Blood Glucose; Cats; Corticostero

1972
Blood sugar responses to epinephrine in the dog in the presence of dual adrenergic blockade.
    European journal of pharmacology, 1972, Volume: 17, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Dogs; Drug Combin

1972
[Study of adrenoline-induced hyperglycemia in bred rainbow trout (Salmo gairdnerii Richardson): action of adrenolytic agents].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1971, Volume: 165, Issue:11

    Topics: Adrenergic beta-Antagonists; Animals; Blood Glucose; Epinephrine; Hyperglycemia; Phentolamine; Pindo

1971
Effects of propanolol and sotalol on epinephrine-induced hyperglycemia and glycogen depletion of liver and muscle in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 147, Issue:1

    Topics: Animals; Blood Glucose; Epinephrine; Fasting; Female; Glycogen; Hyperglycemia; Injections, Intraperi

1974
Effect of adrenergic blocking agents on sympathomimetic amine induced hyperglycemia and hyperlactacidemia.
    Japanese journal of pharmacology, 1974, Volume: 24, Issue:4

    Topics: Animals; Blood Glucose; Catecholamines; Columbidae; Dogs; Epinephrine; Female; Hyperglycemia; Isopro

1974
Effect of hyperglycemia and adrenergic stimulation on growth hormone response during hypovolemic shock.
    Steroids and lipids research, 1974, Volume: 5, Issue:5-6

    Topics: Animals; Blood Glucose; Growth Hormone; Hyperglycemia; Male; Papio; Phentolamine; Propranolol; Shock

1974
Drug control of hyperglycemia and inhibition of insulin secretion due to centrally administered 2-deoxy-D-glucose.
    The American journal of physiology, 1973, Volume: 224, Issue:5

    Topics: Amphetamine; Animals; Atropine; Autonomic Agents; Drug Synergism; Female; Glucose; Hydroxydopamines;

1973
Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects.
    Diabetes, 1973, Volume: 22, Issue:7

    Topics: Adult; Blood Glucose; Diabetes Mellitus; Epinephrine; Female; Glucose; Glucose Tolerance Test; Human

1973
Effect of acute uremia on various aspects of carbohydrate metabolism in dogs.
    Kidney international, 1973, Volume: 4, Issue:4

    Topics: Acute Disease; Animals; Blood Glucose; Carbohydrate Metabolism; Creatinine; Dogs; Epinephrine; Fasti

1973
[The anti-inflammatory action of adrenaline].
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 205, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Blood Glucose; Capillary Permeabil

1973
Narcotic poisoning: an epidemic disease.
    American family physician, 1973, Volume: 8, Issue:6

    Topics: Diazepam; Glucose; Hospitalization; Humans; Hyperglycemia; Methadone; Myelitis, Transverse; Myoglobi

1973
Letter: Propranolol.
    Annals of internal medicine, 1974, Volume: 80, Issue:2

    Topics: Aged; Female; Humans; Hyperglycemia; Hypoglycemia; Propranolol

1974
Glucagon mediation of growth hormone secretion in juvenile diabetes mellitus.
    The American journal of the medical sciences, 1974, Volume: 267, Issue:6

    Topics: Adolescent; Blood Glucose; Body Weight; Child; Diabetes Mellitus, Type 1; Female; Glucagon; Growth H

1974
Hepatic glycogen and blood glucose control.
    Biochemical pharmacology, 1969, Volume: 18, Issue:10

    Topics: Animals; Blood Glucose; Diet; Drug Synergism; Epinephrine; Ergotamine; Fasting; Glucagon; Hyperglyce

1969
Physiological and drug-induced changes in the glycogen content of mouse brain.
    British journal of pharmacology, 1970, Volume: 39, Issue:1

    Topics: Amphetamine; Animals; Bemegride; Body Temperature; Brain Chemistry; Caffeine; Catecholamines; Circad

1970
Increase in plasma growth hormone concentration in man after infusion of adrenaline-propranolol.
    The Journal of endocrinology, 1970, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Blood Glucose; Epinephrine; Female; Growth Hormone; Humans; Hyperglycemia; Male;

1970
Beta adrenergic receptor mechanisms in the metabolic effects of diazoxide in fasted rats.
    Diabetes, 1970, Volume: 19, Issue:4

    Topics: Animals; Blood Glucose; Diazoxide; Fasting; Glycerides; Hyperglycemia; Lactates; Plasma; Propranolol

1970
Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes.
    The Journal of clinical investigation, 1970, Volume: 49, Issue:12

    Topics: Adult; Antigens; Blood Glucose; Carbon Isotopes; Diabetes Complications; Diabetes Mellitus; Drug Ant

1970
Impairment of hyperglycemic induced growth hormone suppression in hyperthyroidism.
    The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:11

    Topics: Blood Glucose; Catecholamines; Growth Hormone; Humans; Hyperglycemia; Hyperthyroidism; Hypothalamo-H

1968