Page last updated: 2024-11-03

propranolol and Growth Disorders

propranolol has been researched along with Growth Disorders in 26 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Growth Disorders: Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.

Research Excerpts

ExcerptRelevanceReference
"Donohue syndrome (leprechaunism; OMIM *246200) is a rare, recessively inherited disorder of extreme insulin resistance due to mutations in the insulin receptor gene (INSR) causing either defects in insulin binding or receptor autophosphorylation and tyrosine kinase activity."1.39Severe progressive obstructive cardiomyopathy and renal tubular dysfunction in Donohue syndrome with decreased insulin receptor autophosphorylation due to a novel INSR mutation. ( Battelino, T; Bratanič, N; Bratina, N; Hovnik, T; Kovač, J; Paro, D; Podkrajšek, KT; Podnar, T, 2013)
"A report is presented of a girl with Graves' disease, which was diagnosed at the age of 1."1.30Graves' disease associated with exophthalmos, cerebral ventricular dilatation and accelerated growth. ( Arai, H; Arisaka, O; Fujiwara, S; Hosaka, A; Tadokoro, R; Yabuta, K, 1997)
"Graves' disease in a girl with Turner's syndrome (karyotype 46,Xdel(Xp)) is described."1.28Hyperthyroidism accelerates growth in Turner's syndrome. ( de Zegher, F; Dooms, L; Massa, G; Vanderschueren-Lodeweyckx, M, 1992)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199011 (42.31)18.7374
1990's8 (30.77)18.2507
2000's3 (11.54)29.6817
2010's4 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tasat, DR1
Lezón, CE2
Astort, F1
Pintos, PM2
Macri, EV1
Friedman, SM1
Boyer, PM3
Herndon, DN1
Voigt, CD1
Capek, KD1
Wurzer, P1
Guillory, A1
Kline, A1
Andersen, CR1
Klein, GL1
Tompkins, RG1
Suman, OE1
Finnerty, CC1
Meyer, WJ1
Sousse, LE1
Olivera, MI1
Bozzini, C2
Mandalunis, P1
Alippi, RM1
Esteban Lezón, C1
Itatí Olivera, MI1
Hovnik, T1
Bratanič, N1
Podkrajšek, KT1
Kovač, J1
Paro, D1
Podnar, T1
Bratina, N1
Battelino, T1
Colle, M1
Battin, J1
Coquelin, JP1
Rochiccioli, P3
Pombo Arias, M1
Morla-Baez, E1
García de Coen, J1
Beltré, M1
García, M1
Lim, YJ1
Kwan, E1
Low, LC1
Enjaume, C1
Tauber, MT1
Pienkowski, C1
Oliver, I1
Dickerman, Z1
Guyda, H1
Tannenbaum, GS1
Arisaka, O1
Hosaka, A1
Arai, H1
Fujiwara, S1
Tadokoro, R1
Yabuta, K1
Philippi, H1
Pohlenz, J1
Grimm, W1
Koffler, T1
Schönberger, W1
Muñoz-Hoyos, A1
Hubber, E1
Escames, G1
Molina-Carballo, A1
Macías, M1
Valenzuela-Ruiz, A1
Fernández-García, JM1
Acuña-Castroviejo, D1
Fass, B1
Lippe, BM1
Kaplan, SA1
Enjeaume, P1
Dutau, G1
Ribot, C1
Augier, D1
Bernasconi, S2
Giovannelli, G1
Andler, W2
Biro, G1
Giovanelli, G1
Fine, RN1
Yadin, O1
Moulten, L1
Nelson, PA1
Boechat, MI1
Lippe, BH1
Massa, G1
de Zegher, F1
Dooms, L1
Vanderschueren-Lodeweyckx, M1
Palayew, K1
Crock, P1
Pianosi, P1
Coates, A1
Weitzner, G1
Schiffrin, A1
Casanova Fernández, M1
Chihara, K1
Kodama, H1
Kaji, H1
Kita, T1
Kashio, Y1
Okimura, Y1
Abe, H1
Fujita, T1
Lee, PA1
Thompson, RG1
Blizzard, RM1
Parks, JS2
Amrhein, JA1
Vaidya, V2
Moshang, T2
Bongiovanni, AM2

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multicenter Benchmarking of Functional and Psychosocial Outcomes of Pediatric Burn Survivors[NCT00239668]3,000 participants (Anticipated)Observational2000-03-31Completed
Assessment of the Treatment of the Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation[NCT00675714]Phase 2/Phase 31,126 participants (Actual)Interventional2004-01-31Terminated (stopped due to At the request of the study site, this study has been closed and access to study-related data is unavailable. We are unable to submit the results-data.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for propranolol and Growth Disorders

ArticleYear
[Progress in the study of growth retardation].
    Anales espanoles de pediatria, 1984, Oct-15, Volume: 21, Issue:5

    Topics: Adolescent; Age Determination by Skeleton; Child; Child, Preschool; Chromosome Aberrations; Chromoso

1984

Trials

4 trials available for propranolol and Growth Disorders

ArticleYear
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
    Annals of surgery, 2016, Volume: 264, Issue:3

    Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord

2016
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
    Annals of surgery, 2016, Volume: 264, Issue:3

    Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord

2016
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
    Annals of surgery, 2016, Volume: 264, Issue:3

    Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord

2016
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
    Annals of surgery, 2016, Volume: 264, Issue:3

    Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord

2016
Betaxolol and propranolol in glucagon stimulation of growth hormone.
    Archives of disease in childhood, 1984, Volume: 59, Issue:7

    Topics: Adolescent; Adrenergic beta-Antagonists; Betaxolol; Child; Child, Preschool; Female; Glucagon; Growt

1984
Pretreatment with somatostatin analog SMS 201-995 potentiates growth hormone (GH) responsiveness to GH-releasing factor in short children.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:3

    Topics: Adolescent; Arginine; Blood Glucose; Child; Drug Synergism; Female; Growth Disorders; Growth Hormone

1993
Extended recombinant human growth hormone treatment after renal transplantation in children.
    Journal of the American Society of Nephrology : JASN, 1992, Volume: 2, Issue:12 Suppl

    Topics: Adolescent; Adrenal Cortex Hormones; Age Determination by Skeleton; Anthropometry; Child; Female; Gr

1992

Other Studies

21 other studies available for propranolol and Growth Disorders

ArticleYear
mRNA of cytokines in bone marrow and bone biomarkers in response to propranolol in a nutritional growth retardation model.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:5

    Topics: Animals; Biomarkers; Bone Marrow; Bone Remodeling; Disease Models, Animal; Femur; Food Deprivation;

2014
Improved bone status by the beta-blocker propranolol in an animal model of nutritional growth retardation.
    The British journal of nutrition, 2009, Volume: 101, Issue:11

    Topics: Adrenergic beta-Antagonists; Animals; Bone and Bones; Disease Models, Animal; Drug Evaluation, Precl

2009
[Effect of different propranolol doses on skeletal structural and mechanic efficiency in an animal model of growth retardation].
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2012, Volume: 59, Issue:1

    Topics: Animals; Biometry; Bone Density; Bone Development; Disease Models, Animal; Dose-Response Relationshi

2012
Severe progressive obstructive cardiomyopathy and renal tubular dysfunction in Donohue syndrome with decreased insulin receptor autophosphorylation due to a novel INSR mutation.
    European journal of pediatrics, 2013, Volume: 172, Issue:8

    Topics: Cardiomyopathy, Hypertrophic; Donohue Syndrome; Fatal Outcome; Growth Disorders; Humans; Insulin Res

2013
[Propranolol-exercise test for the study of growth hormone levels in children].
    Boletin medico del Hospital Infantil de Mexico, 1983, Volume: 40, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Exercise Test; Female; Growth Disorders; Growth Hormone; Humans

1983
Screening test for growth hormone deficiency: usefulness of L-dopa-propranolol provocative test.
    Journal of paediatrics and child health, 1994, Volume: 30, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Female; Growth Disorders; Growth Hormone; Humans; Infant; Levod

1994
[Statistic study of 5,473 somatotropin secretion stimulation pharmacologic tests (n=9). Proposed weighting coefficient].
    Annales de pediatrie, 1993, Volume: 40, Issue:7

    Topics: Adolescent; Age Determination by Skeleton; Arginine; Betaxolol; Child; Child, Preschool; Clonidine;

1993
Graves' disease associated with exophthalmos, cerebral ventricular dilatation and accelerated growth.
    Archives of disease in childhood, 1997, Volume: 76, Issue:1

    Topics: Adrenergic beta-Agonists; Antithyroid Agents; Brain Diseases; Cerebral Ventricles; Child, Preschool;

1997
Simultaneous stimulation of growth hormone, adrenocorticotropin and cortisol with L-dopa/L-carbidopa and propranolol in children of short stature.
    Acta paediatrica (Oslo, Norway : 1992), 2000, Volume: 89, Issue:4

    Topics: Adolescent; Adrenocorticotropic Hormone; Carbidopa; Child; Child, Preschool; Dopamine Agents; Drug S

2000
Effect of propranolol plus exercise on melatonin and growth hormone levels in children with growth delay.
    Journal of pineal research, 2001, Volume: 30, Issue:2

    Topics: Adolescent; Adrenergic beta-Antagonists; Child; Exercise; Exercise Test; Female; Growth Disorders; G

2001
Relative usefulness of three growth hormone stimulation screening tests.
    American journal of diseases of children (1960), 1979, Volume: 133, Issue:9

    Topics: Child; False Positive Reactions; Growth Disorders; Growth Hormone; Humans; Levodopa; Propranolol; Sl

1979
[Stimulation by the propranolol-glucagon test of somatotropin secretion in 71 children. Results, statistical study and comparison with the insulin-arginine test].
    Archives francaises de pediatrie, 1976, Volume: 33, Issue:5

    Topics: Adolescent; Arginine; Child; Child, Preschool; Female; Glucagon; Growth Disorders; Growth Hormone; H

1976
[Somatotropic response to a propranolol-glucagon test].
    Minerva pediatrica, 1976, May-12, Volume: 28, Issue:17

    Topics: Child; Glucagon; Growth Disorders; Growth Hormone; Humans; Hypothyroidism; Obesity; Pituitary Gland;

1976
A comparative study of serum growth hormone and plasma cortisol levels in stimulation tests with insulin and propranolol-glucagon.
    Acta endocrinologica, 1975, Volume: 80, Issue:1

    Topics: Adolescent; Adult; Blood Glucose; Child; Child, Preschool; Female; Glucagon; Growth Disorders; Growt

1975
Hyperthyroidism accelerates growth in Turner's syndrome.
    Acta paediatrica (Oslo, Norway : 1992), 1992, Volume: 81, Issue:4

    Topics: Child; Female; Graves Disease; Growth Disorders; Humans; Methimazole; Propranolol; Puberty; Thyroid

1992
Growth hormone response in very short children.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1991, Volume: 14, Issue:4

    Topics: Adolescent; Child; Circadian Rhythm; Diagnosis, Differential; Dwarfism, Pituitary; Exercise Test; Fe

1991
[Treatment of children of short stature].
    Anales espanoles de pediatria, 1990, Volume: 33 Suppl 41

    Topics: Child; Clonidine; Growth Disorders; Growth Hormone; Humans; Propranolol

1990
Augmentation by propranolol of growth hormone-releasing hormone-(1-44)-NH2-induced growth hormone release in normal short and normal children.
    The Journal of clinical endocrinology and metabolism, 1985, Volume: 61, Issue:2

    Topics: Child; Child, Preschool; Female; Growth Disorders; Growth Hormone; Growth Hormone-Releasing Hormone;

1985
Relationship of the adrenergic nervous system and growth hormone release in normal adults and children with various growth disorders.
    Metabolism: clinical and experimental, 1974, Volume: 23, Issue:7

    Topics: Adolescent; Adrenocorticotropic Hormone; Arginine; Child; Child, Preschool; Dwarfism; Epinephrine; G

1974
Growth hormone responses to propranolol-glucagon stimulation: a comparison with other tests of growth hormone reserve.
    The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:1

    Topics: Adolescent; Arginine; Blood Glucose; Child; Child, Preschool; Female; Glucagon; Growth Disorders; Gr

1973
Recovery from probable, acquired growth hormone deficiency.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:3

    Topics: Adolescent; Adult; Androgens; Arginine; Blood Glucose; Child; Glucagon; Growth Disorders; Growth Hor

1974