propranolol has been researched along with Glioblastoma in 5 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Propranolol evolved as the strongest TLX agonist and promoted TLX-regulated gene expression in human glioblastoma cells." | 8.02 | Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. ( Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R, 2021) |
| "Norepinephrine, epinephrine, and histamine cause a rapid increase in the concentration of adenosine 3':5'-cyclic monophosphate (cAMP) in a tumor astrocyte cell line derived from a primary culture of a human glioblastoma multiforme." | 7.65 | Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine. ( Clark, RB; Perkins, JP, 1971) |
| " Propranolol evolved as the strongest TLX agonist and promoted TLX-regulated gene expression in human glioblastoma cells." | 4.02 | Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. ( Bischoff-Kont, I; Chaikuad, A; Faudone, G; Fürst, R; Heering, J; Kaiser, A; Knapp, S; Merk, D; Rachor, L; Willems, S; Zhubi, R, 2021) |
| "Norepinephrine, epinephrine, and histamine cause a rapid increase in the concentration of adenosine 3':5'-cyclic monophosphate (cAMP) in a tumor astrocyte cell line derived from a primary culture of a human glioblastoma multiforme." | 3.65 | Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine. ( Clark, RB; Perkins, JP, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haugaard-Kedström, LM | 1 |
| Clemmensen, LS | 1 |
| Sereikaite, V | 1 |
| Jin, Z | 1 |
| Fernandes, EFA | 1 |
| Wind, B | 1 |
| Abalde-Gil, F | 1 |
| Daberger, J | 1 |
| Vistrup-Parry, M | 1 |
| Aguilar-Morante, D | 1 |
| Leblanc, R | 1 |
| Egea-Jimenez, AL | 1 |
| Albrigtsen, M | 1 |
| Jensen, KE | 1 |
| Jensen, TMT | 1 |
| Ivarsson, Y | 1 |
| Vincentelli, R | 1 |
| Hamerlik, P | 1 |
| Andersen, JH | 1 |
| Zimmermann, P | 1 |
| Lee, W | 1 |
| Strømgaard, K | 1 |
| Faudone, G | 1 |
| Bischoff-Kont, I | 1 |
| Rachor, L | 1 |
| Willems, S | 1 |
| Zhubi, R | 1 |
| Kaiser, A | 1 |
| Chaikuad, A | 1 |
| Knapp, S | 1 |
| Fürst, R | 1 |
| Heering, J | 1 |
| Merk, D | 1 |
| Annabi, B | 1 |
| Lachambre, MP | 1 |
| Plouffe, K | 1 |
| Moumdjian, R | 1 |
| Béliveau, R | 1 |
| Caciagli, F | 1 |
| Ciccarelli, R | 1 |
| Ciancetta, S | 1 |
| Di Iorio, P | 1 |
| Caciagli, P | 1 |
| Clark, RB | 1 |
| Perkins, JP | 1 |
5 other studies available for propranolol and Glioblastoma
| Article | Year |
|---|---|
A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Glioblasto | 2021 |
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; HEK293 Cells; Humans; Molecular S | 2021 |
Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion.
Topics: Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Animals; Brain; Brain Neoplasms; Cell Line; En | 2009 |
Adenosine--norepinephrine interactions on cyclic AMP generating system in human tumoral brain slices.
Topics: Adenosine; Adult; Aged; Brain Neoplasms; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; | 1982 |
Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine.
Topics: Astrocytoma; Cells, Cultured; Clone Cells; Cyclic AMP; Depression, Chemical; Epinephrine; Glioblasto | 1971 |