propranolol and Glaucoma studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)

Research Excerpts

Excerpt	Relevance	Reference
"The effect of propranolol (Inderal) on the intraocular pressure (IOP) in glaucoma has been measured."	9.04	The treatment of glaucoma with propranolol (Inderal). A clinical trial. ( Borthne, A, 1976)
"A 78-year-old woman with bilateral exfoliation glaucoma who was receiving warfarin, 2 mg daily, for systemic anticoagulation developed acute visual loss in the right eye several hours after pupillary dilation."	7.70	Hyphema associated with pupillary dilation in a patient with exfoliation glaucoma and warfarin therapy. ( Greenfield, DS; Liebmann, JM; Ritch, R, 1999)
"The intraocular pressure-lowering effect of the beta-blocker Propranolol, in a concentration of 0."	7.66	[Long-term treatment of glaucoma with propranolol ophthalmic solution (author's transl)]. ( Merkle, W; Merté, HJ, 1980)
"Oral doses of propranolol and metoprolol were tested on 24 patients without glaucoma."	7.66	[Effect of a single oral dose of propranolol or metoprolol on the intraocular pressure of persons without glaucoma (author's transl)]. ( Merkle, W; Merté, HJ, 1980)
"In 17 patients with glaucoma and in two with ocular hypertension, all of whom had not responded satisfactorily to any conventional therapy, treatment was extended to include propranolol systemically."	7.66	Long-term treatment of glaucoma with systemic propranolol. ( Ohrström, A; Pandolfi, M, 1978)
"In a long-term multicenter open randomized study of 103 patients with glaucoma or intraocular hypertension, oral propranolol combined with 2% pilocarpine was compared with 0."	5.05	Oral and topical adrenergic beta-receptor blockers in glaucoma treatment. A multicenter study. ( Kättström, O; Mortensen, J; Ohrström, A; Polland, W; Stenström, B, 1984)
"In a controlled double-blind cross-over trial in 10 patients comprising six with open-angle glaucoma, three with closed-angle glaucoma, and one with ocular hypertension, a single oral dose of atenolol (50 mg) was significantly more effective than propranolol (40 mg) in reducing ocular tension."	5.04	Atenolol versus propranolol. A comparison of ocular hypotensive effect of an oral dose. ( Cullen, PM; Macdonald, MJ; Phillips, CI, 1976)
"The effect of propranolol (Inderal) on the intraocular pressure (IOP) in glaucoma has been measured."	5.04	The treatment of glaucoma with propranolol (Inderal). A clinical trial. ( Borthne, A, 1976)
"The main purpose of this study was to describe a unique case of retro-orbital infantile hemangioma (IH) simulating a congenital glaucoma requiring prompt management with systemic propranolol."	3.91	Secondary Congenital Glaucoma Associated With Retro-orbital Infantile Hemangioma: A Masquerade Syndrome. ( Beylerian, M; Dambricourt, L; Denis, D; Matonti, F; Ramtohul, P, 2019)
"A 78-year-old woman with bilateral exfoliation glaucoma who was receiving warfarin, 2 mg daily, for systemic anticoagulation developed acute visual loss in the right eye several hours after pupillary dilation."	3.70	Hyphema associated with pupillary dilation in a patient with exfoliation glaucoma and warfarin therapy. ( Greenfield, DS; Liebmann, JM; Ritch, R, 1999)
"It has been shown in experiments on rabbits that alpha-and beta-adrenoblockers, and lithium chloride solution exert different effect on intraocular tension of healthy animals with experimental glaucoma and transitory hypertension."	3.66	[Role of the sympathetic nervous system in the pathogenesis of experimental glaucoma]. ( Kopp, OP; Kryzhanovskiĭ, GN; Lipovetskaia, EM, 1980)
"The intraocular pressure-lowering effect of the beta-blocker Propranolol, in a concentration of 0."	3.66	[Long-term treatment of glaucoma with propranolol ophthalmic solution (author's transl)]. ( Merkle, W; Merté, HJ, 1980)
" Paradoxically, one of these agents, timolol, causes a fall in intraocular pressure when administered locally even in patients responding to beta-agonists with a reduction in intraocular pressure."	3.66	beta-Blockers and the eye: an overview. ( Katz, IM, 1978)
"Topical administration of Isoproterenol reduces the intraocular pressure in glaucomatous eyes, but produces systemic side-effects (tachycardia arterial hypotension) that make its clinical use unadvisable."	3.65	[On the possibility of reducing systemic side-effects of isoproterenol eyedrops by means of topical propranolol (author's transl)]. ( Bucci, MG; Pescosolido, N, 1977)
"Ten patients with glaucoma or ocular hypertension (totally 15 pathological eyes and 5 healthy) who had had topical timolol for at least 2 months received the coded oral treatment."	2.65	A combination of oral and topical beta-blockers with additive effects on intraocular pressure. ( Kättström, O; Ohrström, A, 1983)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (92.45)	18.7374
1990's	1 (1.89)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (5.66)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Nocentini, A	1
Ceruso, M	1
Bua, S	1
Lomelino, CL	1
Andring, JT	1
McKenna, R	1
Lanzi, C	1
Sgambellone, S	1
Pecori, R	1
Matucci, R	1
Filippi, L	1
Gratteri, P	1
Carta, F	1
Masini, E	1
Selleri, S	1
Supuran, CT	1
Ramtohul, P	1
Beylerian, M	1
Dambricourt, L	1
Matonti, F	1
Denis, D	1
Kaushik, S	1
Kaur, S	1
Pandav, SS	1
Gupta, A	1
Phillips, CI	5
Howitt, G	1
Rowlands, DJ	1
Kryzhanovskiĭ, GN	1
Lipovetskaia, EM	1
Kopp, OP	1
Koch-Weser, J	1
Frishman, WH	1
Belen'kiĭ, KR	1
Kiĭko, IuI	1
Akhmetshina, NS	1
Reibaldi, A	1
Giummarra, C	1
Ciracì, G	1
Merkle, W	3
Ohrström, A	5
Kättström, O	2
Polland, W	1
Mortensen, J	1
Stenström, B	1
Merté, HJ	3
Greenfield, DS	1
Liebmann, JM	1
Ritch, R	1
Macdonald, MJ	1
Cullen, PM	1
Wettrell, K	4
Katz, IM	1
Boger, WP	1
Virno, M	4
Pellegrino, N	1
Pecori-Giraldi, J	1
Cozza, R	1
Pandolfi, M	4
Tieri, O	2
Rossini, L	1
Goś, R	2
Stankiewicz, A	3
Kudliński, W	1
Borthne, A	1
Bucci, MG	3
Pescosolido, N	1
Bietti, GB	3
De Caro, G	1
Giraldi, JP	2
Romani, E	1
Takase, M	1
Chrzanowska-Srzednicka, K	1
Osterczy-Sliwińska, H	1
Dubielowa, J	1
Srebro, A	1
Krawczykowa, Z	1
Polzella, A	1
Holland, MG	1
Weinstein, P	1
Vale, J	2
Musini, A	1
Fabbri, B	1
Bergamaschi, M	1
Mandelli, V	1
Shanks, RG	1
Gibbs, AC	1
Quaranta, CA	1
Missiroli, A	3
Langham, ME	1
el-Shewy, TM	1
Amin, E	1
Marinosci, F	1
Pivetti-Pezzi, P	1
Coté, G	1
Drance, SM	1
Pecori Giraldi, J	1
McDonald, TO	1
Hodges, JW	1
Borgmann, AR	1
Leaders, FE	1

Article	Year
beta-Adrenoceptor antagonists: new drugs and new indications. The New England journal of medicine, 1981, Aug-27, Volume: 305, Issue:9 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Glaucoma; Humans; Hypertension; Kinetics; Me	1981
Autonomic drugs in ophthalmology: Some problems and promises. Section IV: Sympatholytic and sympathetic blocking agents--alpha adrenergic antagonists and beta adrenergic antagonists. Annals of ophthalmology, 1974, Volume: 6, Issue:11 Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Dibenzocycloheptenes;	1974
[Selected problems of pharmacology and toxicology of the eye]. Klinika oczna, 1970, Volume: 40, Issue:2 Topics: Acetazolamide; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Drug-Related Side Effects an	1970
Role of adrenergic mechanisms in development and therapy of open-angled glaucoma. Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:6 Topics: Adolescent; Adult; Animals; Aqueous Humor; Dibenzocycloheptenes; Drug Synergism; Epinephrine; Glauco	1971

Article	Year
[Results with new beta receptor blockaders in the therapy of glaucoma]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1983, Volume: 79, Issue:5 Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Glaucoma; Humans; Levobunolol; Metipranolol;	1983
A combination of oral and topical beta-blockers with additive effects on intraocular pressure. Acta ophthalmologica, 1983, Volume: 61, Issue:6 Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Clinical Trials as Topic; Double-Blind Meth	1983
Oral and topical adrenergic beta-receptor blockers in glaucoma treatment. A multicenter study. Acta ophthalmologica, 1984, Volume: 62, Issue:5 Topics: Administration, Oral; Clinical Trials as Topic; Glaucoma; Glaucoma, Open-Angle; Hemodynamics; Humans	1984
Atenolol versus propranolol. A comparison of ocular hypotensive effect of an oral dose. The British journal of ophthalmology, 1976, Volume: 60, Issue:11 Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Blood Pressure; Clinical Trials as Topic; Female; Glauc	1976
Intraocular pressure reduction during treatment with pilocarpine and systemic propranolol. A comparative double-masked study. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1977, Sep-30, Volume: 204, Issue:1 Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Glaucoma; Humans; Intraocular Pr	1977
Propranolol vs acetazolamide. A long-term double-masked study of the effect on intraocular pressure and blood pressure. Archives of ophthalmology (Chicago, Ill. : 1960), 1979, Volume: 97, Issue:2 Topics: Acetazolamide; Aged; Blood Pressure; Double-Blind Method; Electrolytes; Female; Glaucoma; Heart Rate	1979
The treatment of glaucoma with propranolol (Inderal). A clinical trial. Acta ophthalmologica, 1976, Volume: 54, Issue:3 Topics: Aged; Circadian Rhythm; Clinical Trials as Topic; Drug Evaluation; Female; Glaucoma; Humans; Intraoc	1976
Early dose response analysis of ocular hypotensive effects of propranolol in patients with ocular hypertension. The British journal of ophthalmology, 1976, Volume: 60, Issue:10 Topics: Adult; Aged; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Glaucoma; Humans; I	1976
Receptor paralyzing agents applied in the treatment of glaucoma simplex. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1969, Volume: 2, Issue:4 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Axons; Clinical Trials as Topic; Drug Syn	1969
Topical propranolol and ocular tension in the human. The British journal of ophthalmology, 1972, Volume: 56, Issue:10 Topics: Administration, Topical; Aged; Clinical Trials as Topic; Female; Glaucoma; Humans; Intraocular Press	1972

Article	Year
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. Journal of medicinal chemistry, 2018, 06-28, Volume: 61, Issue:12 Topics: Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystall	2018
Secondary Congenital Glaucoma Associated With Retro-orbital Infantile Hemangioma: A Masquerade Syndrome. Journal of glaucoma, 2019, Volume: 28, Issue:6 Topics: Diagnosis, Differential; Female; Glaucoma; Hemangioma; Humans; Hydrophthalmos; Infant; Intraocular P	2019
Intractable choroidal effusion with exudative retinal detachment in Sturge-Weber syndrome. JAMA ophthalmology, 2014, Volume: 132, Issue:9 Topics: Administration, Oral; Antihypertensive Agents; Child, Preschool; Choroid Neoplasms; Exudates and Tra	2014
Propranolol as ocular hypotensive agent. The British journal of ophthalmology, 1967, Volume: 51, Issue:4 Topics: Glaucoma; Humans; Injections, Intravenous; Intraocular Pressure; Propranolol; Tonometry, Ocular	1967
[Role of the sympathetic nervous system in the pathogenesis of experimental glaucoma]. Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:5 Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Epinephrine; Glaucoma; Intraocular Pressure; Lithiu	1980
[Problem of stabilization of the glaucoma process]. Oftalmologicheskii zhurnal, 1981, Volume: 36, Issue:5 Topics: Adrenergic beta-Antagonists; Glaucoma; Humans; Intraocular Pressure; Propranolol	1981
[The effect of antiglaucoma drugs on the depth of the anterior chamber (I)]. Bollettino della Societa italiana di biologia sperimentale, 1982, Aug-15, Volume: 58, Issue:15 Topics: Adult; Anterior Chamber; Carbachol; Clonidine; Glaucoma; Humans; Middle Aged; Miotics; Moxisylyte; P	1982
[Long-term treatment of glaucoma with propranolol ophthalmic solution (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1980, Volume: 177, Issue:4 Topics: Aged; Blood Pressure; Glaucoma; Humans; Intraocular Pressure; Middle Aged; Propranolol; Pulse	1980
[Effect of a single oral dose of propranolol or metoprolol on the intraocular pressure of persons without glaucoma (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1980, Volume: 176, Issue:1 Topics: Administration, Oral; Glaucoma; Humans; Intraocular Pressure; Metoprolol; Propanolamines; Propranolo	1980
Hyphema associated with pupillary dilation in a patient with exfoliation glaucoma and warfarin therapy. American journal of ophthalmology, 1999, Volume: 128, Issue:1 Topics: Aged; Anticoagulants; Atrial Fibrillation; Carbachol; Cerebrovascular Disorders; Drug Therapy, Combi	1999
Beta-blockers in the treatment of chronic simple glaucoma. British medical journal, 1976, Jan-24, Volume: 1, Issue:6003 Topics: Adrenergic beta-Antagonists; Glaucoma; Humans; Pindolol; Practolol; Propranolol	1976
beta-adrenoceptor antagonism and intraocular pressure. A clinical study on propranolol, practolol and atenolol. Acta ophthalmologica. Supplementum, 1977, Issue:134 Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure	1977
beta-Blockers and the eye: an overview. Annals of ophthalmology, 1978, Volume: 10, Issue:7 Topics: Adrenergic beta-Antagonists; Animals; Drug Synergism; Drug Therapy, Combination; Epinephrine; Glauco	1978
The treatment of glaucoma: role of beta-blocking agents. Drugs, 1979, Volume: 18, Issue:1 Topics: Administration, Topical; Adrenergic beta-Antagonists; Atenolol; Glaucoma; Humans; Intraocular Pressu	1979
Adrenergic drugs: ocular vasomotricity and vascular permeability. Bibliotheca anatomica, 1979, Issue:18 Topics: Aqueous Humor; Capillary Permeability; Epinephrine; Eye; Glaucoma; Humans; Isoproterenol; Osmotic Pr	1979
[Sympathomimetic and sympatholytic drugs in the therapy of glaucoma (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1977, Volume: 171, Issue:4 Topics: Albuterol; Clonidine; Epinephrine; Glaucoma; Humans; Isoproterenol; Norepinephrine; Propranolol; Sym	1977
[Antiglaucomatous therapy with reduced concentrations (author's transl)]. Journal francais d'ophtalmologie, 1978, Volume: 1, Issue:3 Topics: Drug Therapy, Combination; Epinephrine; Glaucoma; Guanethidine; Humans; Intraocular Pressure; Ophtha	1978
[Propranolol in treatment of simple glaucoma (author's transl)]. Klinika oczna, 1978, Volume: 48, Issue:7 Topics: Adult; Aged; Glaucoma; Humans; Middle Aged; Pilocarpine; Propranolol	1978
Long-term treatment of glaucoma with systemic propranolol. American journal of ophthalmology, 1978, Volume: 86, Issue:3 Topics: Blood Pressure; Glaucoma; Humans; Propranolol; Time Factors	1978
[Approaches in medical treatment in glaucoma (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1977, Volume: 170, Issue:2 Topics: Acetazolamide; Antihypertensive Agents; Clonidine; Delayed-Action Preparations; Glaucoma; Guanethidi	1977
[On the possibility of reducing systemic side-effects of isoproterenol eyedrops by means of topical propranolol (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1977, Volume: 170, Issue:4 Topics: Adolescent; Adult; Glaucoma; Humans; Intraocular Pressure; Isoproterenol; Ophthalmic Solutions; Prop	1977
[Special indications for the use of soft contact lenses as a drug-release-system (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1976, Volume: 168, Issue:1 Topics: Alcohols; Antihypertensive Agents; Clonidine; Contact Lenses, Hydrophilic; Delayed-Action Preparatio	1976
[Effects of propranolol on aqueous dynamics in primary open-angle glaucoma (author's transl)]. Nippon Ganka Gakkai zasshi, 1976, Volume: 80, Issue:6 Topics: Adult; Aqueous Humor; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Propranolol	1976
[Propranolol in the treatment of chronic simple glaucoma and juvenile glaucoma]. Klinika oczna, 1975, Volume: 45, Issue:2 Topics: Adolescent; Adult; Age Factors; Aged; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle A	1975
[Propranolol in the treatment of simple glaucoma. Preliminary communication]. Klinika oczna, 1975, Volume: 45, Issue:4 Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Glaucoma; Humans; Middle Aged; Pilocarpine;	1975
[Clinical use and action mechanism of propranolol]. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1975, Volume: 170, Issue:1 Topics: Administration, Topical; Aqueous Humor; Chronic Disease; Depression, Chemical; Glaucoma; Humans; Int	1975
Effect of DL- and D-propranolol on oscular tension in rabbits and patients. Experimental eye research, 1970, Volume: 9, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Blood Pressure; Glaucoma; Humans; Injections, I	1970
Comparison of the effect of propranolol, lignocaine, and other drugs on normal and raised intraocular pressure in man. American journal of ophthalmology, 1971, Volume: 72, Issue:4 Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Anesthetics, Local; C	1971
Treatment of ocular hypertension with oral beta-adrenergic blocking agents. Acta ophthalmologica, 1974, Volume: 52, Issue:4 Topics: Administration, Oral; Aged; Depression, Chemical; Female; Follow-Up Studies; Glaucoma; Humans; Intra	1974
[Significance and therapy of glaucoma]. Klinische Monatsblatter fur Augenheilkunde, 1973, Volume: 162, Issue:3 Topics: Acid-Base Equilibrium; Alkalies; Alkalosis; Animals; Aqueous Humor; Ascorbic Acid; Epinephrine; Glau	1973
[Clinical picture of glucocorticoid-induced glaucoma and its treatment]. Bulletins et memoires de la Societe francaise d'ophtalmologie, 1973, Volume: 86, Issue:0 Topics: Adolescent; Adult; Child; Child, Preschool; Female; Glaucoma; Glucocorticoids; Humans; Hyaluronogluc	1973
Clinical experience with propranolol in the treatment of glaucoma. Acta ophthalmologica, 1973, Volume: 51, Issue:5 Topics: Adult; Aged; Cataract; Cataract Extraction; Depression, Chemical; Female; Glaucoma; Humans; Intraocu	1973
Conservative management of the glaucomas. Transactions of the ophthalmological societies of the United Kingdom, 1966, Volume: 86 Topics: Ascorbic Acid; Echothiophate Iodide; Epinephrine; Glaucoma; Humans; Iris; Pilocarpine; Propranolol;	1966
Effect of beta-adrenergic blockade with propranolol on the intraocular pressure. Bulletin of the Ophthalmological Society of Egypt, 1969, Volume: 62, Issue:66 Topics: Adolescent; Adult; Child; Depression, Chemical; Female; Glaucoma; Humans; Intraocular Pressure; Male	1969
[Study on the mechanism of action of 2 intraocular hypotensive agents: ergotamine and propranolol]. Bollettino d'oculistica, 1969, Volume: 48, Issue:12 Topics: Animals; Ergotamine; Glaucoma; Humans; Intraocular Pressure; Ophthalmic Solutions; Propranolol; Rabb	1969
[Behavior of intraocular pressure in 2 cases of Marchesani's syndrome after treatment with local propranolol (inderal)]. Bollettino d'oculistica, 1970, Volume: 49, Issue:9 Topics: Abnormalities, Multiple; Adolescent; Child; Female; Fingers; Glaucoma; Humans; Propranolol; Toes	1970
The effect of propranolol on human intraocular pressure. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1968, Volume: 3, Issue:3 Topics: Aqueous Humor; Blood Pressure; Epinephrine; Glaucoma; Humans; Intraocular Pressure; Propranolol	1968
[The local administration of propranolo in the therapy of glaucoma]. Bollettino d'oculistica, 1968, Volume: 47, Issue:1 Topics: Glaucoma; Humans; Propranolol	1968
The water-loading test in rabbits. A method to detect potential ocular hypotensive drugs. Archives of ophthalmology (Chicago, Ill. : 1960), 1969, Volume: 82, Issue:3 Topics: Acetazolamide; Animals; Atropine; Carbachol; Dichlorphenamide; Epinephrine; Glaucoma; Hexamethonium	1969

propranolol and Glaucoma

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