Page last updated: 2024-11-03

propranolol and Gastric Ulcer

propranolol has been researched along with Gastric Ulcer in 39 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Research Excerpts

ExcerptRelevanceReference
" The results revealed that 100 mg/kg nimesulide produces gastric ulceration in adrenalectomized rats, which is prevented by prednisolone and adrenaline."3.74Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats. ( Cadirci, E; Gocer, F; Hacimuftuoglu, A; Halici, Z; Keles, S; Suleyman, H, 2007)
"The effects of a benzodiazepine receptor inverse agonist (FG 7142) on gastric ulcer formation were studied in restrained rats."3.67A benzodiazepine receptor inverse agonist inhibits stress-induced ulcer formation. ( Ginter, H; Skolnick, P; Trullas, R, 1987)
"1 Effects of graded doses of propranolol have been studied on gastric secretion and gastric ulcers in pylorus-ligated rats."3.65Effects of propranolol on gastric secretion in albino rats. ( Das, DG; Debnath, PK; Gode, KD; Sanyal, AK, 1974)
"Propranolol pretreatment in the highest dose (10 mg/kg) given either intraperitoneally (i."1.29A study of the antiulcer mechanisms of propranolol in rats. ( Cho, CH; Kaan, SK, 1996)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199027 (69.23)18.7374
1990's11 (28.21)18.2507
2000's1 (2.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Suleyman, H1
Halici, Z1
Cadirci, E1
Hacimuftuoglu, A1
Keles, S1
Gocer, F1
Buchel, L1
Gallaire, D1
Lebrec, D1
Nouel, O1
Bernuau, J1
Bouygues, M1
Rueff, B1
Benhamou, JP1
Daly, MJ1
Nobrega, JN1
Wiener, NI1
Ruoff, HJ1
Painz, B1
Gladziwa, U1
Becker, M1
Sewing, KF1
Malchow, H1
Yat, PC1
Cho, CH3
Ray, A1
Henke, PG1
Gulati, K1
Sen, P1
Koriakina, LA1
Kaan, SK2
Mei, QB1
Clementi, G1
Caruso, A1
Cutuli, VM1
de Bernardis, E1
Prato, A1
Mangano, NG1
Amico-Roxas, M1
Dai, S1
Ogle, CW1
Kasuya, Y1
Urushidani, T1
Okabe, S5
Rainsford, KD1
Takeuchi, K2
Takagi, K4
Christensen, KC1
Stadil, F2
Hermansen, K1
Gavrovskaia, LK1
Sedov, VM1
Kharchevnikova, EN1
Morozov, VP1
Kuratani, K1
Yamazaki, M1
Kodama, H1
Yamaguchi, I1
Bispo, DL1
Pereira, OC1
Hidalgo, J1
Gasull, T1
Garcia, A1
Blanquez, A1
Armario, A1
Bhandare, P1
Diniz-D'Souza, R1
Mainker, A1
Dhume, V1
Trullas, R1
Ginter, H1
Skolnick, P1
Basistiuk, II1
Nakane, S1
Sakai, T1
Rosoff, CB1
Goldman, H1
Saziki, R2
Haffner, J1
Aune, S1
Jansson, G1
Stadaas, JO1
Honda, K1
Debnath, PK1
Gode, KD1
Das, DG1
Sanyal, AK1
Bhargava, KP1
Gupta, MB1
Tangri, KK1
Zhuk, EA1
Meves, M1
Meiisel, P1
Kronborg, O1
Pedersen, T1
Rehfeld, JF1
Kohút, A1
Nicák, A1
Danhof, IE1
Geumei, A1
Gáti, T1
Keszler, P1
Zelles, T1
Pucsok, J1
Yano, S1
Kawashima, K1
Rösch, J1
Gray, RK1
Grollman, JH1
Ross, G1
Steckel, RJ1
Weiner, M1

Reviews

1 review available for propranolol and Gastric Ulcer

ArticleYear
The classification of adrenoceptors and their effects on gastric acid secretion.
    Scandinavian journal of gastroenterology. Supplement, 1984, Volume: 89

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Albuterol; Animals; Atropine; Bethanechol

1984

Trials

2 trials available for propranolol and Gastric Ulcer

ArticleYear
Propranolol in prevention of recurrent gastrointestinal bleeding in cirrhotic patients.
    Lancet (London, England), 1981, Apr-25, Volume: 1, Issue:8226

    Topics: Clinical Trials as Topic; Esophageal and Gastric Varices; Humans; Liver Cirrhosis; Peptic Ulcer Hemo

1981
The effect of beta-adrenergic blockade upon gastric acid secretion and gastrin secretion during hypoglycaemia before and after vagotomy.
    Scandinavian journal of gastroenterology, 1974, Volume: 9, Issue:2

    Topics: Blood Glucose; Clinical Trials as Topic; Depression, Chemical; Duodenal Ulcer; Gastric Juice; Gastri

1974

Other Studies

36 other studies available for propranolol and Gastric Ulcer

ArticleYear
Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:3

    Topics: Adrenalectomy; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; alpha-

2007
[Restraint ulcers in rats. II. Study of protective substances].
    Archives des sciences physiologiques, 1967, Volume: 21, Issue:4

    Topics: Animals; Barbiturates; Bis-Trimethylammonium Compounds; Butyrophenones; Chloral Hydrate; Chlorpromaz

1967
Effects of catecholamine agonist and antagonist drugs on acute stomach ulceration induced by medial hypothalamic lesions in rats.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:5

    Topics: Amphetamine; Animals; Catecholamines; Chlorpromazine; Clozapine; Desipramine; Haloperidol; Hypothala

1983
Adrenaline sensitive adenylate cyclase in human gastric mucosa.
    Pharmacology, 1981, Volume: 23, Issue:3

    Topics: Adenylyl Cyclases; Adult; Aged; Cimetidine; Duodenal Ulcer; Epinephrine; Female; Gastric Mucosa; Hum

1981
Effects of beta-adrenoceptor antagonists on portal vein hypertension and ethanol-induced gastric mucosal damage in rats.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Ethanol; Gastric Mucosa; Hemodynamics; Hypertension, Portal; L

1994
The amygdaloid complex, corticotropin releasing factor and stress-induced gastric ulcerogenesis in rats.
    Brain research, 1993, Oct-08, Volume: 624, Issue:1-2

    Topics: Amygdala; Animals; Benzylamines; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug;

1993
[A comparison of the effects of cyproheptadine and propranolol on the development of poststressor lesions of the gastric mucosa in inbred mice].
    Fiziologicheskii zhurnal imeni I.M. Sechenova, 1993, Volume: 79, Issue:9

    Topics: Animals; Creatinine; Cyproheptadine; Drug Combinations; Gastric Mucosa; Injections, Intraventricular

1993
A study of the antiulcer mechanisms of propranolol in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:8

    Topics: Adrenergic beta-Antagonists; Animals; Anti-Ulcer Agents; Blood Pressure; Ethanol; Gastric Mucosa; He

1996
A mechanistic study of beta-adrenoceptor antagonists on ethanol-induced gastric damage.
    European journal of pharmacology, 1996, Dec-12, Volume: 317, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Butoxamine; Central Nervous System Depressants; Dinoprostone;

1996
Effects of centrally of peripherally injected adrenomedullin on reserpine-induced gastric lesions.
    European journal of pharmacology, 1998, Oct-30, Volume: 360, Issue:1

    Topics: Adrenalectomy; Adrenomedullin; Animals; Anti-Ulcer Agents; Calcitonin Gene-Related Peptide; Calciton

1998
Effects of stress and of autonomic blockers on gastric mucosal microcirculation in rats.
    European journal of pharmacology, 1975, Volume: 30, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Chlorpromazine; Cold T

1975
Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat.
    Japanese journal of pharmacology, 1979, Volume: 29, Issue:4

    Topics: Aluminum Hydroxide; Amylopectin; Animals; Anti-Ulcer Agents; Atropine; Chlorpromazine; Hexamethonium

1979
The role of aspirin in gastric ulceration . Some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions.
    The American journal of digestive diseases, 1978, Volume: 23, Issue:6

    Topics: Animals; Arthritis, Experimental; Aspirin; Atropine Derivatives; Bethanechol Compounds; Cold Tempera

1978
A new model of stress ulcer in the rat with pylorus ligation and its pathogenesis.
    The American journal of digestive diseases, 1976, Volume: 21, Issue:9

    Topics: Amylopectin; Animals; Atropine; Bicarbonates; Chlorpromazine; Disease Models, Animal; Gastric Mucosa

1976
Beta-adrenergic mechanisms and ulcer formation in pylorus-ligated rats.
    Scandinavian journal of gastroenterology, 1975, Volume: 10, Issue:7

    Topics: Animals; Depression, Chemical; Gastric Juice; Gastrins; Ligation; Male; Propranolol; Pylorus; Rats;

1975
[Physiological significance of gastroduodenal blood flow and possibilities of its regulation by drugs].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1992, Issue:8

    Topics: Animals; Clemastine; Duodenum; Gastric Mucosa; Histamine H1 Antagonists; Histamine H2 Antagonists; H

1992
Possible involvement of hyperinsulinemia and adrenergic activation in the pathogenesis of indomethacin-induced antral ulcers in nonfasted hamsters and refed rats.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3

    Topics: Animals; Atropine; Cricetinae; Famotidine; Fasting; Indomethacin; Insulin; Male; Mesocricetus; Prazo

1992
Involvement of swimming-induced acute stress in the sensitivity of rat vs deferens to norepinephrine.
    General pharmacology, 1992, Volume: 23, Issue:6

    Topics: Adrenal Glands; Adrenalectomy; Animals; Cocaine; In Vitro Techniques; Male; Muscle, Smooth; Norepine

1992
Role of glucocorticoids and catecholamines on hepatic thiobarbituric acid reactants in basal and stress conditions in the rat.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1991, Volume: 23, Issue:3

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Analysis of Variance; Animals; Corticostero

1991
Protective effect of propranolol on ethanol-induced gastric lesions in mice.
    European journal of pharmacology, 1990, Nov-27, Volume: 191, Issue:2

    Topics: Administration, Oral; Animals; Ethanol; Gastrointestinal Hemorrhage; Indomethacin; Injections, Intra

1990
A benzodiazepine receptor inverse agonist inhibits stress-induced ulcer formation.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:1

    Topics: Animals; Carbolines; Chlordiazepoxide; Male; Propranolol; Rats; Rats, Inbred Strains; Receptors, GAB

1987
[Microcirculatory disorders and their correction in patients with acute ulcer-related gastrointestinal hemorrhage].
    Klinicheskaia khirurgiia, 1988, Issue:4

    Topics: Aged; Gastric Mucosa; Humans; Ischemia; Microcirculation; Middle Aged; Pentoxifylline; Peptic Ulcer

1988
[Effect of several drugs on the development of stress ulcer and seepage of a pigment from the stomach of rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1974, Volume: 70, Issue:1

    Topics: Animals; Atropine; Autonomic Agents; Chlorpromazine; Dibenzylchlorethamine; Gastric Juice; Gastric M

1974
Effect of the intestinal bacterial flora on acute gastric stress ulceration.
    Gastroenterology, 1968, Volume: 55, Issue:2

    Topics: Acute Disease; Animals; Atropine; Endotoxins; Escherichia coli; Gastric Juice; Immobilization; Intes

1968
Effects of adrenergic blocking agents on gastric secretion and stress-induced gastric ulcer in rats.
    Japanese journal of pharmacology, 1970, Volume: 20, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Depression, Chemical; Dibenzylch

1970
[Nervous regulation of gastric motility].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1971, Mar-20, Volume: 91, Issue:8

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Duodenal Ulcer; Epinephrin

1971
Effects of phentolamine mesylate and propranolol hydrochloride on aspirin-induced gastric lesions and gastric secretions in the rat.
    Japanese journal of pharmacology, 1974, Volume: 24, Issue:3

    Topics: Animals; Aspirin; Body Weight; Gastric Mucosa; Male; Phentolamine; Propranolol; Pylorus; Rats; Stoma

1974
Effects of propranolol on gastric secretion in albino rats.
    British journal of pharmacology, 1974, Volume: 51, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Female; Gastric Juice; Gastric Mucosa; Ligation; Male; Pr

1974
Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.
    European journal of pharmacology, 1973, Volume: 22, Issue:2

    Topics: Adrenal Glands; Adrenalectomy; Animals; Atropine; Cordotomy; Dose-Response Relationship, Drug; Femal

1973
[Participation of catecholamines in the development of corticosteroid lesions in the gastric mucous membrane].
    Biulleten' eksperimental'noi biologii i meditsiny, 1972, Volume: 73, Issue:5

    Topics: Animals; Catecholamines; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Mitosis; Parasympatholyt

1972
[Angiographic diagnosis and therapy of acute gastrointestinal hemorrhage].
    Medizinische Klinik, 1972, Apr-07, Volume: 67, Issue:14

    Topics: Aged; Angiography; Epinephrine; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage;

1972
[Stomach ulcer induced by phenylbutazone and its course in adult rats].
    Bratislavske lekarske listy, 1972, Volume: 57, Issue:3

    Topics: Adrenal Glands; Adrenalectomy; Animals; Epinephrine; Metyrapone; Phenylbutazone; Promethazine; Propr

1972
Effect of propranolol on gastric acid secretion in rats.
    British journal of pharmacology, 1972, Volume: 46, Issue:1

    Topics: Animals; Gastric Juice; Male; Propranolol; Rats; Secretory Rate; Stomach Ulcer

1972
Effect of adrenergic receptor blocking agents on the development of experimental ulcer in the rat.
    Acta physiologica Academiae Scientiarum Hungaricae, 1971, Volume: 40, Issue:3

    Topics: Animals; Ligation; Phenoxybenzamine; Propranolol; Pylorus; Rats; Reserpine; Stomach Ulcer; Sympathol

1971
The effect of propranolol on the stress and Shay ulcerations in rats.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:2

    Topics: Animals; Male; Propranolol; Rats; Stomach Ulcer; Stress, Physiological

1969
Selective arterial drug infusions in the treatment of acute gastrointestinal bleeding. A preliminary report.
    Gastroenterology, 1970, Volume: 59, Issue:3

    Topics: Acute Disease; Adult; Aged; Alcoholism; Animals; Colitis; Colitis, Ulcerative; Diverticulum, Colon;

1970