propranolol and Fetal Hypoxia

propranolol has been researched along with Fetal Hypoxia in 12 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Fetal Hypoxia: Deficient oxygenation of FETAL BLOOD.

Research

Studies (12)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Median Apgar Score at 5 Minutes

The Apgar score is a simple method of quickly assessing the health and vital signs of a newborn baby created by and named after Dr. Virginia Apgar. Apgar testing assesses Appearance, Pulse, Grimace and Activity in a newborn and is typically done at one and five minutes after a baby is born, and it may be repeated at 10, 15, and 20 minutes if the score is low. The five criteria are each scored as 0, 1, or 2 (two being the best), and the total score is calculated by then adding the five values obtained. Agar scores of 0-3 are critically low, 4-6 are below normal, and indicate that the baby likely requires medical intervention, scores of 7+ are considered normal. The lower the Apgar score, the more alert the medical team should be to the possibility of the baby requiring intervention. Some components of the Apgar score are subjective, and there are cases in which a baby requires urgent medical treatment despite having a high Apgar score. (NCT01131260)
Timeframe: 5 minutes after Delivery

Median Duration of Labor Post-randomization

Duration of labor in hours after randomization through delivery (NCT01131260)
Timeframe: Onset of Labor through delivery

Median Length of Hospital Stay

Days of stay in the hospital (NCT01131260)
Timeframe: From admission to labor and delivery through hospital discharge

Number of Infants Admitted to Special Care Nursery

Intermediate care nursery or neonatal intensive care (anything more than well-baby nursery) (NCT01131260)
Timeframe: Delivery and 1 month of age

Number of Infants Experiencing Neonatal Encephalopathy (Primary Outcome Component)

Neonatal encephalopathy experienced between delivery and discharge (NCT01131260)
Timeframe: Delivery through hospital discharge

Number of Infants Who Experienced Neonatal Seizure (Primary Outcome Component)

Number of infants who experienced Neonatal Seizure (NCT01131260)
Timeframe: Birth through hospital discharge

Number of Infants With a Major Congenital Malformation

Major congenital malformation (NCT01131260)
Timeframe: Delivery

Number of Infants With Apgar Score < = 3 at 5 Minutes (Primary Outcome Component)

The Apgar score is a simple method of quickly assessing the health and vital signs of a newborn baby created by and named after Dr. Virginia Apgar. Apgar testing assesses Appearance, Pulse, Grimace and Activity in a newborn and is typically done at one and five minutes after a baby is born, and it may be repeated at 10, 15, and 20 minutes if the score is low. The five criteria are each scored as 0, 1, or 2 (two being the best), and the total score is calculated by then adding the five values obtained. Agar scores of 0-3 are critically low, 4-6 are below normal, and indicate that the baby likely requires medical intervention, scores of 7+ are considered normal. The lower the Apgar score, the more alert the medical team should be to the possibility of the baby requiring intervention. Some components of the Apgar score are subjective, and there are cases in which a baby requires urgent medical treatment despite having a high Apgar score. The lowest score is 0, the highest score is 10. (NCT01131260)
Timeframe: 5 minutes after delivery

Number of Infants With Meconium Aspiration Syndrome

Meconium aspiration syndrome (NCT01131260)
Timeframe: Delivery through discharge

Number of Infants With Umbilical-artery Blood pH < = 7.05 and Base Deficit in Extracellular Fluid > = 12 mmol/Liter (Primary Outcome Component)

Umbilical-artery blood pH < = 7.05 and base deficit in extracellular fluid > = 12 mmol/liter (NCT01131260)
Timeframe: Delivery

Number of Intrapartum Fetal Deaths (Primary Outcome Component)

Death of the fetus during the intrapartum period. (NCT01131260)
Timeframe: During labor and through delivery of the baby

Number of Neonatal Deaths (Primary Outcome Component)

Death of the newborn between delivery and1 month of age (NCT01131260)
Timeframe: Delivery through1 month of age

Number of Neonates Intubated for Ventilation at Delivery (Primary Outcome Component)

Neonatal intubation for ventilation in the delivery room (NCT01131260)
Timeframe: Delivery

Number of Neonates With Shoulder Dystocia During Delivery

Presence of shoulder dystocia during delivery (NCT01131260)
Timeframe: Delivery

Number of Participants Experiencing Postpartum Endometritis

Postpartum endometritis (NCT01131260)
Timeframe: Delivery through hospital discharge

Number of Participants Who Had a Postpartum Blood Transfusion

Blood transfusion from delivery and through hospital stay until discharge (NCT01131260)
Timeframe: Delivery through hospital discharge

Number of Participants With Chorioamnionitis

Chorioamnionitis (NCT01131260)
Timeframe: Any time from Randomization through Delivery

Number of Participants With Primary Composite Outcome

Composite primary outcome of intrapartum fetal death, neonatal death, Apgar score <=3 at 5 minutes, neonatal seizure, umbilical artery blood pH <= 7.05 with base deficit >=12 mmol/L in extra-cellular fluid, intubation for ventilation at delivery, neonatal encelphalopathy (NCT01131260)
Timeframe: From Delivery through 1 month of age

Number of Participants With an Indication for Forceps or Vacuum Delivery

Indication for delivery by forceps or vacuum (NCT01131260)
Timeframe: During labor through delivery

Reviews

1 review available for propranolol and Fetal Hypoxia

Other Studies

11 other studies available for propranolol and Fetal Hypoxia