Page last updated: 2024-11-03

propranolol and Endothelioma, Vascular

propranolol has been researched along with Endothelioma, Vascular in 21 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Research Excerpts

ExcerptRelevanceReference
"Transcatheter arterial embolization combined with propranolol is an effective treatment for life-threatening infantile hepatic hemangioendothelioma."7.96Infantile hepatic hemangioendothelioma associated with pulmonary artery hypertension and cardiac insufficiency successfully treated with transcatheter arterial embolization and propranolol: A case report. ( Guo, L; Li, J; Song, D; Wang, L; Wu, C; Yin, J, 2020)
"A newborn with unresectable kaposiform hemangioendothelioma associated with Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second-line treatment with propranolol at a dose of 2 mg/kg/day, starting at 2 months of life and continued for 13 months."7.83Successful Propranolol Treatment of a Kaposiform Hemangioendothelioma Apparently Resistant to Propranolol. ( Berti, E; Calvani, M; Defilippi, C; Della Bona, ML; Donzelli, G; Favre, C; Filippi, L; la Marca, G; Perrone, A; Tamburini, A, 2016)
"There is currently no consensus on the second-line management of Kaposiform hemangioendothelioma (KHE) that was resistant to prednisolone and vincristine."7.81Successful treatment of Kaposiform hemangioendothelioma with everolimus. ( Ito, S; Miyazaki, O; Mori, T; Nakazawa, A; Terashima, K; Uno, T, 2015)
"Propranolol is a non-selective beta-adrenergic antagonist successfully used in a case of kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon (KMP)."7.78Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon. ( Blei, F; Carcao, M; Chiu, YE; Drolet, BA; Fangusaro, J; Kelly, ME; Krol, A; Lofgren, S; Mancini, AJ; Metry, DW; Pope, E; Recht, M; Silverman, RA; Tom, WL, 2012)
"A brief comment on efficacy and safety of propranolol in the treatment of parotid hemangioma is presented, with illustration of a typical case."7.77Comment on efficacy and safety of propranolol in the treatment of parotid hemangioma. ( Zheng, JW, 2011)
"Kaposiform hemangioendothelioma is a rare vascular tumor in children."5.37Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: a new indication for propranolol treatment. ( de Blaauw, I; Hermans, DJ; Kool, LJ; van Beynum, IM; van der Vijver, RJ; van der Vleuten, CJ, 2011)
"Consumptive hypothyroidism due to cutaneous hemangioma and hepatic hemangioendothelioma can be managed with propranolol and low-dose sirolimus."4.12Severe consumptive hypothyroidism in hepatic hemangioendothelioma. ( Dubinski, I; Häberle, B; Küppers, J; Lurz, E; Schmid, I; Schmidt, H; Walther, A, 2022)
"Transcatheter arterial embolization combined with propranolol is an effective treatment for life-threatening infantile hepatic hemangioendothelioma."3.96Infantile hepatic hemangioendothelioma associated with pulmonary artery hypertension and cardiac insufficiency successfully treated with transcatheter arterial embolization and propranolol: A case report. ( Guo, L; Li, J; Song, D; Wang, L; Wu, C; Yin, J, 2020)
"Sirolimus is an effective therapy for children with kaposiform hemangioendothelioma with or without the Kasabach-Merritt phenomenon."3.88 ( Dillingham, CS; Givner, LB; McLean, TW; Rinker, EK; Russell, TB, 2018)
"A newborn with unresectable kaposiform hemangioendothelioma associated with Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second-line treatment with propranolol at a dose of 2 mg/kg/day, starting at 2 months of life and continued for 13 months."3.83Successful Propranolol Treatment of a Kaposiform Hemangioendothelioma Apparently Resistant to Propranolol. ( Berti, E; Calvani, M; Defilippi, C; Della Bona, ML; Donzelli, G; Favre, C; Filippi, L; la Marca, G; Perrone, A; Tamburini, A, 2016)
"There is currently no consensus on the second-line management of Kaposiform hemangioendothelioma (KHE) that was resistant to prednisolone and vincristine."3.81Successful treatment of Kaposiform hemangioendothelioma with everolimus. ( Ito, S; Miyazaki, O; Mori, T; Nakazawa, A; Terashima, K; Uno, T, 2015)
"Propranolol is a non-selective beta-adrenergic antagonist successfully used in a case of kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon (KMP)."3.78Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon. ( Blei, F; Carcao, M; Chiu, YE; Drolet, BA; Fangusaro, J; Kelly, ME; Krol, A; Lofgren, S; Mancini, AJ; Metry, DW; Pope, E; Recht, M; Silverman, RA; Tom, WL, 2012)
"A brief comment on efficacy and safety of propranolol in the treatment of parotid hemangioma is presented, with illustration of a typical case."3.77Comment on efficacy and safety of propranolol in the treatment of parotid hemangioma. ( Zheng, JW, 2011)
"The patient has hypoxemia due to abdominal distention during the follow-up period."1.46Beta blocker and steroid therapy in the treatment of infantile hepatic hemangioendothelioma. ( Bör, Ö; Düzenli Kar, Y; Kebapçı, M; Özdemir, ZC; Şöhret, NC, 2017)
"Kaposiform hemangioendothelioma is a rare vascular tumor in children."1.37Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: a new indication for propranolol treatment. ( de Blaauw, I; Hermans, DJ; Kool, LJ; van Beynum, IM; van der Vijver, RJ; van der Vleuten, CJ, 2011)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's17 (80.95)24.3611
2020's4 (19.05)2.80

Authors

AuthorsStudies
Walther, A1
Häberle, B1
Küppers, J1
Lurz, E1
Schmid, I1
Schmidt, H1
Dubinski, I1
Yu, L2
Wei, L2
Ma, L2
Li, L2
Wang, L1
Song, D1
Wu, C1
Li, J1
Yin, J1
Guo, L1
Maaloul, I1
Aloulou, H1
Hentati, Y1
Kamoun, T1
Mnif, Z1
Hachicha, M1
Özdemir, ZC1
Düzenli Kar, Y1
Şöhret, NC1
Kebapçı, M1
Bör, Ö1
Russell, TB1
Rinker, EK1
Dillingham, CS1
Givner, LB1
McLean, TW1
Emad, A1
Fadel, S1
El Wakeel, M1
Nagy, N1
Zamzam, M1
Kieran, MW1
El Haddad, A1
Stiles, JM1
Amaya, C1
Rains, S1
Diaz, D1
Pham, R1
Battiste, J1
Modiano, JF1
Kokta, V1
Boucheron, LE1
Mitchell, DC1
Bryan, BA1
Tlougan, BE1
Lee, MT1
Drolet, BA2
Frieden, IJ1
Adams, DM1
Garzon, MC1
Wang, Z1
Li, K1
Dong, K1
Xiao, X1
Zheng, S1
Uno, T1
Ito, S1
Nakazawa, A1
Miyazaki, O1
Mori, T1
Terashima, K1
Korsaga-Somé, N1
Maruani, A1
Abdo, I1
Favrais, G1
Lorette, G1
Filippi, L1
Tamburini, A1
Berti, E1
Perrone, A1
Defilippi, C1
Favre, C1
Calvani, M1
Della Bona, ML1
la Marca, G1
Donzelli, G1
Sarialioglu, F1
Erbay, A1
Demir, S1
Morais, P1
Magina, S1
Mateus, M1
Trindade, E1
Jesus, JM1
Azevedo, F1
Hermans, DJ1
van Beynum, IM1
van der Vijver, RJ1
Kool, LJ1
de Blaauw, I1
van der Vleuten, CJ1
Zheng, JW1
Avagyan, S1
Klein, M1
Kerkar, N1
Demattia, A1
Blei, F3
Lee, S1
Rosenberg, HK1
Arnon, R1
Chiu, YE1
Carcao, M1
Fangusaro, J1
Kelly, ME1
Krol, A1
Lofgren, S1
Mancini, AJ1
Metry, DW1
Recht, M1
Silverman, RA1
Tom, WL1
Pope, E1
Hochman, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sirolimus in the Treatment for Propranolol-resistant Infantile Hepatic Hemangioendothelioma[NCT04406870]Phase 436 participants (Anticipated)Interventional2020-07-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for propranolol and Endothelioma, Vascular

ArticleYear
Medical management of vascular anomalies.
    Facial plastic surgery : FPS, 2012, Volume: 28, Issue:6

    Topics: Adrenergic beta-Antagonists; Hemangioendothelioma; Hemangioma; Humans; Kasabach-Merritt Syndrome; Pr

2012
Management of vascular tumors.
    Facial plastic surgery : FPS, 2012, Volume: 28, Issue:6

    Topics: Adrenergic beta-Antagonists; Child; Granuloma, Pyogenic; Hemangioendothelioma; Hemangioma; Humans; K

2012

Other Studies

19 other studies available for propranolol and Endothelioma, Vascular

ArticleYear
Severe consumptive hypothyroidism in hepatic hemangioendothelioma.
    Journal of pediatric endocrinology & metabolism : JPEM, 2022, Dec-16, Volume: 35, Issue:12

    Topics: Hemangioendothelioma; Humans; Hypothyroidism; Infant; Liver Neoplasms; Male; Propranolol; Sirolimus;

2022
First report of oral atenolol for treatment of kaposiform hemangioendothelioma, a viable alternative to propranolol.
    The Journal of dermatology, 2023, Volume: 50, Issue:4

    Topics: Atenolol; Hemangioendothelioma; Humans; Kasabach-Merritt Syndrome; Propranolol; Sarcoma, Kaposi

2023
First report of oral atenolol for treatment of kaposiform hemangioendothelioma, a viable alternative to propranolol.
    The Journal of dermatology, 2023, Volume: 50, Issue:4

    Topics: Atenolol; Hemangioendothelioma; Humans; Kasabach-Merritt Syndrome; Propranolol; Sarcoma, Kaposi

2023
First report of oral atenolol for treatment of kaposiform hemangioendothelioma, a viable alternative to propranolol.
    The Journal of dermatology, 2023, Volume: 50, Issue:4

    Topics: Atenolol; Hemangioendothelioma; Humans; Kasabach-Merritt Syndrome; Propranolol; Sarcoma, Kaposi

2023
First report of oral atenolol for treatment of kaposiform hemangioendothelioma, a viable alternative to propranolol.
    The Journal of dermatology, 2023, Volume: 50, Issue:4

    Topics: Atenolol; Hemangioendothelioma; Humans; Kasabach-Merritt Syndrome; Propranolol; Sarcoma, Kaposi

2023
Infantile hepatic hemangioendothelioma associated with pulmonary artery hypertension and cardiac insufficiency successfully treated with transcatheter arterial embolization and propranolol: A case report.
    Medicine, 2020, Jun-12, Volume: 99, Issue:24

    Topics: Antihypertensive Agents; Catheterization; Combined Modality Therapy; Embolization, Therapeutic; Hear

2020
Infantile hepatic hemangioendothelioma successfully treated by low dose of propranolol.
    Presse medicale (Paris, France : 1983), 2017, Volume: 46, Issue:4

    Topics: Dose-Response Relationship, Drug; Female; Hemangioendothelioma; Humans; Infant; Liver Neoplasms; Pro

2017
Beta blocker and steroid therapy in the treatment of infantile hepatic hemangioendothelioma.
    Drug discoveries & therapeutics, 2017, Jul-31, Volume: 11, Issue:3

    Topics: Adrenergic beta-Antagonists; Glucocorticoids; Hemangioendothelioma; Hepatomegaly; Humans; Hypothyroi

2017
    Pediatrics, 2018, Volume: 141, Issue:Suppl 5

    Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Drug Therapy,

2018
Outcome of Children Treated for Infantile Hepatic Hemangioendothelioma.
    Journal of pediatric hematology/oncology, 2020, Volume: 42, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Combined Modality Therapy; Female; Follow-Up Studies; Hemangioendot

2020
Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Adrenergic beta-Antagonists; Animals; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement

2013
Medical management of tumors associated with Kasabach-Merritt phenomenon: an expert survey.
    Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:8

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Data Collection; Hemangioendothelioma; Hemangioma; H

2013
Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:8

    Topics: Adrenergic beta-Antagonists; Female; Hemangioendothelioma; Hemangioma; Humans; Kasabach-Merritt Synd

2014
Successful treatment of Kaposiform hemangioendothelioma with everolimus.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Drug Resistance, Neoplasm; Everolimus; Hemang

2015
[Kasabach-Merritt phenomenon (KMP) exacerbated by platelet transfusions].
    Annales de dermatologie et de venereologie, 2015, Volume: 142, Issue:10

    Topics: Aspirin; Axilla; Combined Modality Therapy; Compression Bandages; Disease Progression; Disseminated

2015
Successful Propranolol Treatment of a Kaposiform Hemangioendothelioma Apparently Resistant to Propranolol.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:7

    Topics: Drug Resistance, Neoplasm; Hemangioendothelioma; Humans; Infant, Newborn; Infant, Newborn, Diseases;

2016
Response of infantile hepatic hemangioma to propranolol resistant to high-dose methylprednisolone and interferon-α therapy.
    Pediatric blood & cancer, 2010, Dec-15, Volume: 55, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Hemangioendothelioma; Hum

2010
Efficacy and safety of propranolol in the treatment of parotid hemangioma.
    Cutaneous and ocular toxicology, 2011, Volume: 30, Issue:3

    Topics: Adrenergic beta-Antagonists; Female; Hemangioendothelioma; Hemangioma; Humans; Infant; Liver Neoplas

2011
Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: a new indication for propranolol treatment.
    Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:4

    Topics: Adrenergic beta-Antagonists; Antineoplastic Agents, Phytogenic; Disseminated Intravascular Coagulati

2011
Comment on efficacy and safety of propranolol in the treatment of parotid hemangioma.
    Cutaneous and ocular toxicology, 2011, Volume: 30, Issue:4

    Topics: Adrenergic beta-Antagonists; Female; Hemangioendothelioma; Hemangioma; Humans; Liver Neoplasms; Neop

2011
Propranolol as a first-line treatment for diffuse infantile hepatic hemangioendothelioma.
    Journal of pediatric gastroenterology and nutrition, 2013, Volume: 56, Issue:3

    Topics: Adrenergic beta-2 Receptor Antagonists; Antineoplastic Agents; Congenital Hypothyroidism; Drug Monit

2013
Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon.
    Pediatric blood & cancer, 2012, Volume: 59, Issue:5

    Topics: Adrenergic beta-Antagonists; Child, Preschool; Female; Hemangioendothelioma; Hemangioma; Humans; Inf

2012