propranolol has been researched along with Encephalopathy, Traumatic in 16 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 7.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 3.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| "Propranolol has shown clinical benefit in head injuries; however, the underlying mechanism is also unknown." | 1.91 | Propranolol Reduces p-tau Accumulation and Improves Behavior Outcomes in a Polytrauma Murine Model. ( Collins, SM; England, LG; Goodman, MD; McGlone, ED; Morris, MC; Robson, MJ; Schuster, RM; Singer, KE; Wallen, TE, 2023) |
| "Brain edema was determined by hemispheric wet-to-dry ratios." | 1.72 | Beta blockade in TBI: Dose-dependent reductions in BBB leukocyte mobilization and permeability in vivo. ( Ahmed, S; Culkin, MC; ElSaadani, M; Georges, A; Jacovides, CL; Kaplan, LJ; Kumar, MA; Lopez, AJ; Pascual, JL; Smith, DH, 2022) |
| "Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg." | 1.72 | MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022) |
| "Amitriptyline-induced lower post-TBI HR and improved functional outcomes without affecting inflammatory response." | 1.62 | Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. ( Earnest, R; Goodman, MD; McGlone, E; Morris, MC; Singer, KE; Stevens-Topie, S; Wallen, TE, 2021) |
| "β-blockers have been shown to improve survival after traumatic brain injury (TBI); however, the impact of continuous dosage of β-blockers on cognitive function has not been elucidated." | 1.51 | Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury. ( Bae, EH; Friese, RS; Gries, L; Hamidi, M; Hanna, K; Joseph, B; Kulvatunyou, N; OʼKeeffe, T; Tang, A; Zakaria, ER; Zeeshan, M, 2019) |
| "Propranolol was administered at 1 h post-TBI." | 1.51 | Propranolol protects cerebral autoregulation and reduces hippocampal neuronal cell death through inhibition of interleukin-6 upregulation after traumatic brain injury in pigs. ( Armstead, WM; Vavilala, MS, 2019) |
| "Propranolol was administrated to block the SNS in vivo and NE stimulation was used to imitate the activation of the SNS in vitro." | 1.51 | Acute Traumatic Brain Injury Induces CD4+ and CD8+ T Cell Functional Impairment by Upregulating the Expression of PD-1 via the Activated Sympathetic Nervous System. ( Bai, W; Chen, C; He, X; Kong, C; Su, X; Yang, Y; Ye, Y; Zhang, X, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 11 (68.75) | 2.80 |
| Authors | Studies |
|---|---|
| Dhillon, NK | 1 |
| Hashim, YM | 1 |
| Conde, G | 1 |
| Phillips, G | 1 |
| Fierro, NM | 1 |
| Yong, F | 1 |
| Berezin, N | 1 |
| Ley, EJ | 1 |
| Lopez, AJ | 2 |
| ElSaadani, M | 2 |
| Jacovides, CL | 2 |
| Georges, A | 1 |
| Culkin, MC | 2 |
| Ahmed, S | 1 |
| Kumar, MA | 2 |
| Kaplan, LJ | 2 |
| Smith, DH | 2 |
| Pascual, JL | 2 |
| Baucom, MR | 2 |
| Wallen, TE | 4 |
| Singer, KE | 3 |
| Youngs, J | 1 |
| Schuster, RM | 3 |
| Blakeman, TC | 1 |
| McGuire, JL | 1 |
| Strilka, R | 1 |
| Goodman, MD | 4 |
| Georges, AP | 1 |
| Song, H | 1 |
| McGlone, ED | 1 |
| Collins, SM | 1 |
| Morris, MC | 2 |
| England, LG | 2 |
| Robson, MJ | 1 |
| Pritts, TA | 1 |
| Wang, X | 1 |
| Li, X | 1 |
| Ma, L | 1 |
| Chen, H | 1 |
| You, C | 1 |
| Nordness, MF | 1 |
| Maiga, AW | 1 |
| Wilson, LD | 1 |
| Koyama, T | 1 |
| Rivera, EL | 1 |
| Rakhit, S | 1 |
| de Riesthal, M | 1 |
| Motuzas, CL | 1 |
| Cook, MR | 1 |
| Gupta, DK | 1 |
| Jackson, JC | 1 |
| Williams Roberson, S | 1 |
| Meurer, WJ | 1 |
| Lewis, RJ | 1 |
| Manley, GT | 1 |
| Pandharipande, PP | 1 |
| Patel, MB | 1 |
| Zeeshan, M | 1 |
| Hamidi, M | 1 |
| OʼKeeffe, T | 1 |
| Bae, EH | 1 |
| Hanna, K | 2 |
| Friese, RS | 1 |
| Kulvatunyou, N | 1 |
| Zakaria, ER | 1 |
| Gries, L | 1 |
| Tang, A | 2 |
| Joseph, B | 3 |
| Armstead, WM | 1 |
| Vavilala, MS | 1 |
| Khalili, H | 1 |
| Ahl, R | 1 |
| Paydar, S | 1 |
| Sjolin, G | 1 |
| Cao, Y | 1 |
| Abdolrahimzadeh Fard, H | 1 |
| Niakan, A | 1 |
| Mohseni, S | 1 |
| Asmar, S | 1 |
| Bible, L | 1 |
| Chehab, M | 1 |
| Khurrum, M | 1 |
| Castanon, L | 1 |
| Ditillo, M | 1 |
| Douglas, M | 1 |
| McGlone, E | 1 |
| Stevens-Topie, S | 1 |
| Earnest, R | 1 |
| Genét, GF | 1 |
| Bentzer, P | 1 |
| Hansen, MB | 1 |
| Ostrowski, SR | 1 |
| Johansson, PI | 1 |
| Pucks-Faes, E | 1 |
| Hitzenberger, G | 1 |
| Matzak, H | 1 |
| Verrienti, G | 1 |
| Schauer, R | 1 |
| Saltuari, L | 1 |
| Yang, Y | 1 |
| Ye, Y | 1 |
| Chen, C | 1 |
| Kong, C | 1 |
| Su, X | 1 |
| Zhang, X | 1 |
| Bai, W | 1 |
| He, X | 1 |
1 review available for propranolol and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Pharmacological components with neuroprotective effects in the management of traumatic brain injury: evidence from network meta-analysis.
Topics: Adult; Bayes Theorem; Brain Injuries, Traumatic; Erythropoietin; Humans; Network Meta-Analysis; Neur | 2023 |
2 trials available for propranolol and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial.
Topics: Adrenergic Agents; Brain Injuries, Traumatic; Clonidine; Humans; Pilot Projects; Propranolol; Treatm | 2023 |
Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial.
Topics: Adrenergic beta-Antagonists; Adult; Brain Injuries, Traumatic; Female; Glasgow Outcome Scale; Hospit | 2020 |
13 other studies available for propranolol and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Early Propranolol Is Associated With Lower Risk of Venous Thromboembolism After Traumatic Brain Injury.
Topics: Adult; Aged; Brain Injuries, Traumatic; Female; Humans; Injury Severity Score; Intensive Care Units; | 2021 |
Beta blockade in TBI: Dose-dependent reductions in BBB leukocyte mobilization and permeability in vivo.
Topics: Animals; Blood-Brain Barrier; Body Weight; Brain Edema; Brain Injuries, Traumatic; Chronic Traumatic | 2022 |
Postinjury Treatment to Mitigate the Effects of Aeromedical Evacuation After Traumatic Brain Injury in a Porcine Model.
Topics: Air Ambulances; Allopurinol; Animals; Brain Injuries, Traumatic; Humans; Interleukin-6; Mice; Propra | 2022 |
Persistent Blunting of Penumbral Leukocyte Mobilization by Beta Blockade Administered for Two Weeks After Traumatic Brain Injury.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Leukoc | 2022 |
Propranolol Reduces p-tau Accumulation and Improves Behavior Outcomes in a Polytrauma Murine Model.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Male; Mice; Multiple Trauma; Pro | 2023 |
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th | 2022 |
Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Brain Injuries, Traumatic; CA1 Region, Hippocampal; | 2019 |
Propranolol protects cerebral autoregulation and reduces hippocampal neuronal cell death through inhibition of interleukin-6 upregulation after traumatic brain injury in pigs.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Brain Injuries, Traumatic; Cell Death; Disea | 2019 |
Traumatic brain injury induced temperature dysregulation: What is the role of β blockers?
Topics: Abbreviated Injury Scale; Adrenergic beta-Antagonists; Atenolol; Body Temperature; Brain Injuries, T | 2021 |
Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
Topics: Adenosine; Air Ambulances; Allopurinol; Amitriptyline; Animals; Brain; Brain Chemistry; Brain Injuri | 2021 |
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Blood-Brain Barrier; Bra | 2018 |
Intrathecal baclofen in paroxysmal sympathetic hyperactivity: Impact on oral treatment.
Topics: Administration, Oral; Adolescent; Adult; Antihypertensive Agents; Autonomic Nervous System Diseases; | 2018 |
Acute Traumatic Brain Injury Induces CD4+ and CD8+ T Cell Functional Impairment by Upregulating the Expression of PD-1 via the Activated Sympathetic Nervous System.
Topics: Adrenergic beta-Antagonists; Animals; Brain Contusion; Brain Injuries, Traumatic; CD4-Positive T-Lym | 2019 |