Page last updated: 2024-11-03

propranolol and Drug Overdose

propranolol has been researched along with Drug Overdose in 37 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"The cases of two asthmatic adolescents who overdosed on albuterol are presented."7.68Propranolol treatment of albuterol poisoning in two asthmatic patients. ( Henretig, F; Joffe, M; Ramoska, EA; Spiller, HA, 1993)
"Hypertension is a potential complication following ephedrine and pseudoephedrine overdoses."7.68Intravenous propranolol reverses hypertension after sympathomimetic overdose: two case reports. ( Burkhart, KK, 1992)
"We describe a case of massive propranolol overdose in a healthy 19-year-old woman associated with isolated mesenteric ischemia following shock."7.68Nonocclusive mesenteric ischemia associated with propranolol overdose: implications regarding splanchnic circulation. ( Abramson, S; Levy, J; Pettei, MJ, 1990)
"Propranolol was successfully tapered over 3 weeks by reducing the dose by 50% weekly until it reached the therapeutic dose."5.91Excessively High Chronic Propranolol Overdose in Infantile Hemangioma: A Case Report. ( Alessa, A; Alghanem, A; Alhammad, AM; Alshammari, H; Elsharawy, Y, 2023)
"Propranolol is a highly lipid-soluble beta-blocker."5.37Severe propranolol and ethanol overdose with wide complex tachycardia treated with intravenous lipid emulsion: a case report. ( Brajkovic, G; Gligic, B; Jovic-Stosic, J; Putic, V; Spasic, R, 2011)
"1 kg) was admitted to a hospital emergency department with lethargy and bradycardia after an unintentional overdose of propranolol suspension, which had been prescribed several days previously for treatment of a scalp hemangioma."3.83Intravenous lipid emulsion and high-dose insulin as adjunctive therapy for propranolol toxicity in a pediatric patient. ( Franco Palacios, CR; Henriksen, MN; Thompson, AM, 2016)
"The cases of two asthmatic adolescents who overdosed on albuterol are presented."3.68Propranolol treatment of albuterol poisoning in two asthmatic patients. ( Henretig, F; Joffe, M; Ramoska, EA; Spiller, HA, 1993)
"Hypertension is a potential complication following ephedrine and pseudoephedrine overdoses."3.68Intravenous propranolol reverses hypertension after sympathomimetic overdose: two case reports. ( Burkhart, KK, 1992)
"A case of refractory hypotension following propranolol overdose is reported."3.68Extracorporeal circulation in the management of massive propranolol overdose. ( Corke, CF; McVey, FK, 1991)
"We describe a case of massive propranolol overdose in a healthy 19-year-old woman associated with isolated mesenteric ischemia following shock."3.68Nonocclusive mesenteric ischemia associated with propranolol overdose: implications regarding splanchnic circulation. ( Abramson, S; Levy, J; Pettei, MJ, 1990)
"Propranolol was successfully tapered over 3 weeks by reducing the dose by 50% weekly until it reached the therapeutic dose."1.91Excessively High Chronic Propranolol Overdose in Infantile Hemangioma: A Case Report. ( Alessa, A; Alghanem, A; Alhammad, AM; Alshammari, H; Elsharawy, Y, 2023)
"Amphotericin B was the only other antifungal that demonstrated a 2D SDR with CHF-related events."1.39A quantitative analysis of the spontaneous reporting of congestive heart failure-related adverse events with systemic anti-fungal drugs. ( Hauben, M; Hung, EY, 2013)
" In patients with life-saving use in suicide attempts important role in addition to medication dosage plays an elapsed time of their consumption and speed of action taken to remove and prevent absorbtion the poison", as well as close supervision in the intensive care unit."1.38[Drugs acting on the heart-conductive system in suicide attempts]. ( Dabek, J; Jakubowski, D; Rychlik, W; Stachoń, K, 2012)
"Propranolol is a highly lipid-soluble beta-blocker."1.37Severe propranolol and ethanol overdose with wide complex tachycardia treated with intravenous lipid emulsion: a case report. ( Brajkovic, G; Gligic, B; Jovic-Stosic, J; Putic, V; Spasic, R, 2011)
"Clenbuterol is a β(2)-adrenergic receptor agonist licensed for veterinary use as a bronchodilator."1.37Clenbuterol toxicosis in three Quarter Horse racehorses after administration of a compounded product. ( Barker, SA; Bauer, RW; McConnico, RS; Mirza, MH; Morgan, TW; Thompson, JA, 2011)
"Brugada syndrome is characterized by the electrocardiographic (ECG) pattern of right bundle-branch block (RBBB) with a high take-off, coved ST-segment elevation in the precordial leads V1 to V3, and the risk of sudden cardiac death."1.36Brugada-pattern electrocardiogram in propranolol intoxication. ( Littmann, L; Rennyson, SL, 2010)
"We report two clinical cases of cardiac arrest, the former due to an adverse effect of intravenous (i."1.33Enoximone in cardiac arrest caused by propranolol: two case reports. ( Antonelli, M; Caricato, A; Cavallaro, F; Fenici, P; Sandroni, C; Scapigliati, A, 2006)
"This child developed significant acute dilated cardiomyopathy and severe CNS depression 2 hours after ingesting 3200 mg of propranolol."1.30Acute dilated cardiomyopathy and central nervous system toxicity following propranolol intoxication. ( Lifshitz, M; Zalzstein, E; Zucker, N, 1999)
" Though acute reversible psychosis has been appreciated after initiating or increasing propranolol dosage therapeutically, this association has not been reported in the literature regarding beta blocker overdose or intoxication."1.29Toxic psychosis: an unusual presentation of propranolol intoxication. ( Handler, JA; Love, JN, 1995)
"Propranolol was the only beta blocker associated with seizure; of those who ingested more than 2 g of propranolol, two thirds had a seizure."1.29Relative toxicity of beta blockers in overdose. ( Buckley, NA; Dawson, AH; Epid, D; Reith, DM; Sayer, GP; Whyte, IM, 1996)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (43.24)18.2507
2000's6 (16.22)29.6817
2010's14 (37.84)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Alshammari, H1
Alessa, A1
Elsharawy, Y1
Alghanem, A1
Alhammad, AM1
Mangiapia, G1
Gvaramia, M1
Kuhrts, L1
Teixeira, J1
Koutsioubas, A1
Soltwedel, O1
Frielinghaus, H1
Xue, J1
Zhang, L1
Qin, Z1
Li, R1
Wang, Y1
Zhu, K1
Li, X1
Gao, X1
Zhang, J1
Macala, KF1
Khadaroo, RG1
Panahi, S1
Gragasin, FS1
Bourque, SL1
Hauben, M1
Hung, EY1
Macala, K1
Tabrizchi, R1
Thompson, AM1
Franco Palacios, CR1
Henriksen, MN1
Le Fevre, P1
Gosling, M1
Acharya, K1
Georgiou, A1
Leppikangas, H1
Ruokonen, E1
Rutanen, J1
Kiviniemi, V1
Lindgren, L1
Kurola, J1
Rennyson, SL1
Littmann, L1
Majlesi, N1
Greller, HA1
McGuigan, MA1
Caraccio, T1
Su, MK1
Chan, GM1
Dean, P1
Ruddy, JP1
Marshall, S1
Samuels, TL1
Uncles, DR1
Willers, JW1
Monteiro, R1
Halloran, C1
Jovic-Stosic, J1
Gligic, B1
Putic, V1
Brajkovic, G1
Spasic, R1
Thompson, JA1
Mirza, MH1
Barker, SA1
Morgan, TW1
Bauer, RW1
McConnico, RS1
Dabek, J1
Stachoń, K1
Jakubowski, D1
Rychlik, W1
Boyd, R1
Ghosh, A1
Farhangi, V1
Sansone, RA1
Sandroni, C1
Cavallaro, F1
Caricato, A1
Scapigliati, A1
Fenici, P1
Antonelli, M1
Sakamoto, T1
Yoshioka, T1
Shirakawa, Y1
Kamei, T1
Murata, A1
Asari, Y1
Okumura, T1
Endo, Y1
Shimazu, T1
Tomioka, J1
Love, JN2
Handler, JA1
Ramoska, EA1
Henretig, F1
Joffe, M1
Spiller, HA1
Duffy, N1
Toet, AE2
te Biesebeek, JD2
Vleeming, W2
Wemer, J2
Meulenbelt, J2
de Wildt, DJ2
Reith, DM1
Dawson, AH1
Epid, D1
Whyte, IM1
Buckley, NA1
Sayer, GP1
Lin, YJ1
Liu, YB1
Wu, CC1
Chen, WJ1
Lee, YT1
Chodorowski, Z1
Sein Anand, J1
Hazouard, E1
Ferrandière, M1
Lesire, V1
Joye, F1
Perrotin, D1
de Toffol, B1
Lifshitz, M1
Zucker, N1
Zalzstein, E1
Fucci, N1
Offidani, C1
Leasure, JA1
Mundt, DJ1
Janz, TG1
Burkhart, KK1
Brimacombe, JR1
Scully, M1
Swainston, R1
McVey, FK1
Corke, CF1
Pettei, MJ1
Levy, J1
Abramson, S1
Mansell, PI1

Reviews

2 reviews available for propranolol and Drug Overdose

ArticleYear
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Glucagon for the treatment of symptomatic beta blocker overdose.
    Emergency medicine journal : EMJ, 2003, Volume: 20, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Drug Overdose; Emergencies; Evidence-Based Medicine; Female; Glu

2003
[Guidelines for the treatment of acute chemical poisoning-11-symptomatic therapy 4. Management of circulation for drug overdose and poisoning].
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2007, Volume: 20, Issue:1

    Topics: Acute Disease; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Cardiac

2007

Other Studies

35 other studies available for propranolol and Drug Overdose

ArticleYear
Excessively High Chronic Propranolol Overdose in Infantile Hemangioma: A Case Report.
    The American journal of case reports, 2023, Nov-27, Volume: 24

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Child; Drug Overdose; Female; Hemangioma; Hemangi

2023
Effect of benzocaine and propranolol on phospholipid-based bilayers.
    Physical chemistry chemical physics : PCCP, 2017, Dec-06, Volume: 19, Issue:47

    Topics: Anesthetics, Local; Benzocaine; Cell Membrane; Drug Overdose; Lipid Bilayers; Neutron Diffraction; P

2017
No obvious sympathetic excitation after massive levothyroxine overdose: A case report.
    Medicine, 2018, Volume: 97, Issue:23

    Topics: Adrenergic beta-Antagonists; Adult; Drug Overdose; Female; Humans; Propranolol; Renal Dialysis; Symp

2018
Low dose Intralipid resuscitation improves survival compared to ClinOleic in propranolol overdose in rats.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Animals; Drug Overdose; Emulsions; Fat Emulsions, Intravenous; Hemodynamics; Kaplan-Meier Estimate;

2018
A quantitative analysis of the spontaneous reporting of congestive heart failure-related adverse events with systemic anti-fungal drugs.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:7

    Topics: Adverse Drug Reaction Reporting Systems; Amphotericin B; Antifungal Agents; Databases, Factual; Drug

2013
The effect of fat emulsion on hemodynamics following treatment with propranolol and clonidine in anesthetized rats.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2014, Volume: 21, Issue:11

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Clonidine; D

2014
Intravenous lipid emulsion and high-dose insulin as adjunctive therapy for propranolol toxicity in a pediatric patient.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2016, Jun-15, Volume: 73, Issue:12

    Topics: Administration, Intravenous; Bradycardia; Combined Modality Therapy; Drug Overdose; Fat Emulsions, I

2016
Dramatic resuscitation with Intralipid in an epinephrine unresponsive cardiac arrest following overdose of amitriptyline and propranolol.
    BMJ case reports, 2017, Mar-02, Volume: 2017

    Topics: Adult; Amitriptyline; Drug Overdose; Epinephrine; Fat Emulsions, Intravenous; Female; Heart Arrest;

2017
Levosimendan as a rescue drug in experimental propranolol-induced myocardial depression: a randomized study.
    Annals of emergency medicine, 2009, Volume: 54, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Dobutamine; Double-Blind Method; Drug Over

2009
Brugada-pattern electrocardiogram in propranolol intoxication.
    The American journal of emergency medicine, 2010, Volume: 28, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Brugada Syndrome; Drug Overdose; Electrocardiography; Female; Hu

2010
Thyroid storm after pediatric levothyroxine ingestion.
    Pediatrics, 2010, Volume: 126, Issue:2

    Topics: Adrenergic beta-Antagonists; Child, Preschool; Drug Overdose; Female; Humans; Propranolol; Thyrotoxi

2010
Intravenous lipid emulsion in propranolol [corrected] overdose.
    Anaesthesia, 2010, Volume: 65, Issue:11

    Topics: Adult; Cardiovascular Agents; Drug Overdose; Electrocardiography; Fat Emulsions, Intravenous; Female

2010
Logging the potential for intravenous lipid emulsion in propranolol and other lipophilic drug overdoses.
    Anaesthesia, 2011, Volume: 66, Issue:3

    Topics: Cardiovascular Agents; Drug Overdose; Fat Emulsions, Intravenous; Humans; Propranolol

2011
Severe propranolol and ethanol overdose with wide complex tachycardia treated with intravenous lipid emulsion: a case report.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Drug Overdose; Electrocardiography; Ethanol; Fat Emulsions, Intr

2011
Clenbuterol toxicosis in three Quarter Horse racehorses after administration of a compounded product.
    Journal of the American Veterinary Medical Association, 2011, Sep-15, Volume: 239, Issue:6

    Topics: Animals; Chromatography, Liquid; Clenbuterol; Drug Compounding; Drug Overdose; Fluid Therapy; Horse

2011
[Drugs acting on the heart-conductive system in suicide attempts].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2012, Volume: 33, Issue:194

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Calcium Channel Blockers; Causality; Comorbidity; Dru

2012
QTc prolongation due to propranolol overdose.
    International journal of psychiatry in medicine, 2003, Volume: 33, Issue:2

    Topics: Adolescent; Drug Overdose; Electrocardiography; Female; Humans; Long QT Syndrome; Propranolol; Sever

2003
Enoximone in cardiac arrest caused by propranolol: two case reports.
    Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Advanced Cardiac Life Support; Cardiotonic Agents; Drug Overdose

2006
Toxic psychosis: an unusual presentation of propranolol intoxication.
    The American journal of emergency medicine, 1995, Volume: 13, Issue:5

    Topics: Acute Disease; Adult; Drug Overdose; Emergencies; Female; Humans; Propranolol; Psychoses, Substance-

1995
Propranolol treatment of albuterol poisoning in two asthmatic patients.
    Annals of emergency medicine, 1993, Volume: 22, Issue:9

    Topics: Adolescent; Albuterol; Asthma; Charcoal; Drug Overdose; Female; Gastric Lavage; Humans; Hypokalemia;

1993
A 33-year-old woman with a propranolol and chlorpromazine overdose, with applied nursing diagnoses.
    Journal of emergency nursing, 1993, Volume: 19, Issue:1

    Topics: Adult; Chlorpromazine; Critical Care; Drug Overdose; Education, Nursing, Continuing; Female; Glucago

1993
Reduced survival after isoprenaline/dopamine in d,l-propranolol intoxicated rats.
    Human & experimental toxicology, 1996, Volume: 15, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Blood Gas Analysis; Blood

1996
Relative toxicity of beta blockers in overdose.
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:3

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child, Preschool; Databases, Factual

1996
Experimental study of the detrimental effect of dopamine/glucagon combination in d,l-propranolol intoxication.
    Human & experimental toxicology, 1996, Volume: 15, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Blood Gas Analysis; Blood Pressure; Calcium; Disease Models, A

1996
Painless Prinzmetal's ST elevation related to propranolol: a case report.
    International journal of cardiology, 1997, Aug-08, Volume: 60, Issue:3

    Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Angina Pectoris, Variant; Drug Overdo

1997
Acute poisoning with clenbuterol--a case report.
    Przeglad lekarski, 1997, Volume: 54, Issue:10

    Topics: Adrenergic beta-Agonists; Adult; Clenbuterol; Drug Administration Schedule; Drug Overdose; Humans; M

1997
Peduncular hallucinosis related to propranolol self-poisoning: efficacy of intravenous glucagon.
    Intensive care medicine, 1999, Volume: 25, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Diagnosis, Differential; Drug Overdose; Female; Gastrointestinal Agents;

1999
Acute dilated cardiomyopathy and central nervous system toxicity following propranolol intoxication.
    Pediatric emergency care, 1999, Volume: 15, Issue:4

    Topics: Acute Disease; Adolescent; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Antidotes; Cardiom

1999
An unusual death by propranolol ingestion.
    The American journal of forensic medicine and pathology, 2000, Volume: 21, Issue:1

    Topics: Antihypertensive Agents; Autopsy; Cause of Death; Drug Overdose; Gas Chromatography-Mass Spectrometr

2000
A comparison of amrinone and glucagon therapy for cardiovascular depression associated with propranolol toxicity in a canine model.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:3

    Topics: Amrinone; Animals; Cardiovascular Diseases; Depression, Chemical; Dogs; Drug Overdose; Electrocardio

1992
Intravenous propranolol reverses hypertension after sympathomimetic overdose: two case reports.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:1

    Topics: Adult; Blood Pressure; Charcoal; Drug Overdose; Ephedrine; Female; Gastric Lavage; Heart Rate; Human

1992
Propranolol overdose--a dramatic response to calcium chloride.
    The Medical journal of Australia, 1991, Aug-19, Volume: 155, Issue:4

    Topics: Adult; Calcium Chloride; Drug Overdose; Female; Humans; Propranolol

1991
Extracorporeal circulation in the management of massive propranolol overdose.
    Anaesthesia, 1991, Volume: 46, Issue:9

    Topics: Adult; Drug Overdose; Extracorporeal Circulation; Female; Humans; Hypotension; Propranolol; Suicide,

1991
Nonocclusive mesenteric ischemia associated with propranolol overdose: implications regarding splanchnic circulation.
    Journal of pediatric gastroenterology and nutrition, 1990, Volume: 10, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Drug Overdose; Esophageal and Gastric Varices; Female; Humans; I

1990
Glucagon in the management of deliberate self-poisoning with propranolol.
    Archives of emergency medicine, 1990, Volume: 7, Issue:3

    Topics: Coma; Drug Overdose; Female; Glucagon; Humans; Middle Aged; Propranolol; Suicide, Attempted

1990