propranolol has been researched along with Down Syndrome in 3 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Down syndrome has long been associated with a variety of autoimmune conditions." | 2.38 | Hyperthyroidism and Down syndrome. ( Cheah, JS; Tambyah, PA, 1993) |
| "Karyotyping proved trisomy 21." | 1.36 | Hyperthyroidism in a case of Down syndrome. ( Barhate, KS; Dedhia, CR; Londhey, VA; More, AV; Rajadhyaksh, GC, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Londhey, VA | 1 |
| Rajadhyaksh, GC | 1 |
| Barhate, KS | 1 |
| More, AV | 1 |
| Dedhia, CR | 1 |
| Tambyah, PA | 1 |
| Cheah, JS | 1 |
| Mir, GH | 1 |
| Cumming, GR | 1 |
1 review available for propranolol and Down Syndrome
| Article | Year |
|---|---|
Hyperthyroidism and Down syndrome.
Topics: Adolescent; Adult; Carbimazole; Down Syndrome; Drug Therapy, Combination; HLA-B Antigens; Humans; Hy | 1993 |
2 other studies available for propranolol and Down Syndrome
| Article | Year |
|---|---|
Hyperthyroidism in a case of Down syndrome.
Topics: Adolescent; Carbimazole; Down Syndrome; Echocardiography; Humans; Hyperthyroidism; Male; Propranolol | 2010 |
Response to atropine in Down's syndrome.
Topics: Adult; Atropine; Brain Damage, Chronic; Child; Child, Preschool; Dilatation; Down Syndrome; Electroc | 1971 |