propranolol has been researched along with Disease Models, Animal in 461 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This focused review emphasizes the results of clinical trials using β-blocker, losartan potassium, and irbesartan in patients with Marfan syndrome and comments briefly on mechanisms of aortic remodeling, including fibrosis and transforming growth factor β signaling." | 9.01 | Update on Clinical Trials of Losartan With and Without β-Blockers to Block Aneurysm Growth in Patients With Marfan Syndrome: A Review. ( Eagle, KA; Hofmann Bowman, MA; Milewicz, DM, 2019) |
| "Propranolol can reduce the formation of abnormal retinal neovascularization in oxygen-induced retinopathy (OIR) models, and reduce leaking, tortuous, and abnormally expanding retinal blood vessels." | 8.31 | Propranolol ameliorates retinopathy of prematurity in mice by downregulating HIF-1α via the PI3K/Akt/ERK pathway. ( Ding, Y; Liu, L; Liu, Y; Su, S; Wang, Y; Yang, G; Zhang, J; Zou, P, 2023) |
| " There are some reports have shown that curcumin, the major component of curcuma, has a good curative effect on psoriasis, but the mechanism is still unknown, so the present study was designed to investigate the effect of curcuma's extraction on psoriasis-like mouse, and to explore the mechanisms of therapy." | 7.96 | Curcuma's extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin, proliferating cell nuclear antigen and toll-like receptor expression. ( He, D; Li, JQ; She, SY; Tong, RS; Zhang, SH; Zhong, ZD, 2020) |
| "Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats." | 7.91 | Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats. ( Araujo, IG; Império, GE; Marassi, MP; Mecawi, AS; Olivares, EL; Reis, LC; Seara, FAC; Silva, ACM, 2019) |
| "To investigate the effect of acupuncture at PC6 on cardiac hypertrophy in isoproterenol (ISO)-treated mice." | 7.91 | Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice. ( Du, Q; Guo, Y; Hou, Y; Yang, F; Zhang, M; Zhu, P, 2019) |
| "Propranolol is an approved non-selective β-adrenergic blocker that is first line therapy for infantile hemangioma." | 7.91 | R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. ( Andelfinger, G; Bischoff, J; Chiang, IK; Fontaine, F; Francois, M; Gambin, Y; Hamdan, M; Huang, L; Khosrotehrani, K; Lesieur, E; Meurer, M; Moustaqil, M; Overman, J; Pasquier, E; Patel, J; Sierecki, E; Wylie-Sears, J; Zuegg, J, 2019) |
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 7.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| "Astilbin has anti-inflammatory and immunoregulatory effects, and is frequently used in prescriptions treating psoriasis; however, the mechanism remains to be fully elucidated." | 7.88 | Astilbin emulsion improves guinea pig lesions in a psoriasis-like model by suppressing IL-6 and IL-22 via p38 MAPK. ( Lu, C; Xiao, Z; Yu, J; Zhang, Y; Zhao, R, 2018) |
| "We sought to evaluate effect of propranolol in the treatment of infantile hemangiomas by quantifying the amount of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and hypoxia-inducible factor-1α (HIF-1α)." | 7.88 | Propranolol inhibits the activity of PI3K, AKT, and HIF-1α in infantile hemangiomas. ( Huang, G; Lin, H; Lin, Z; Wang, L; Wang, W, 2018) |
| "Propranolol is a vasoactive drug that shows antiangiogenic and antitumour activities in melanoma." | 7.85 | Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. ( Bearzi, C; Buoncervello, M; Catalano, L; Gabriele, L; Giordani, L; Maccari, S; Macchia, D; Marano, G; Rampin, A; Rizzi, R; Spada, M; Stati, T, 2017) |
| "In this work, we evaluated the antitumor effect of metronomic treatment with a combination of two repositioned drugs, metformin and propranolol, in triple negative breast cancer models." | 7.85 | Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. ( André, N; Baglioni, M; Bondarenko, M; Carré, M; Laluce, NC; Menacho Márquez, M; Rico, M; Rozados, V; Scharovsky, OG, 2017) |
| " Using a clinically relevant rodent model of lung contusion (LC), hemorrhagic shock (HS), and chronic stress (CS), we hypothesize that daily propranolol (BB), a nonselective β blocker, restores BM function and improves iron homeostasis." | 7.85 | Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress. ( Alamo, IG; Bible, LE; Efron, PA; Kannan, KB; Loftus, TJ; Mohr, AM; Ramos, H, 2017) |
| "Propranolol could effectively inhibit the formation of retinal neovascularization in mice; the eye drops was more effective than the IP injection." | 7.83 | [Effects of propranolol on oxygen-induced retinal neovascularization in mouse]. ( Huang, X; Wang, Y; Yang, G; Yang, Z; Zhang, J, 2016) |
| "To evaluate the inhibitory effects of propranolol, a nonselective and lipophilic β-adrenergic receptor blocker, on alkali-induced corneal neovascularization (NV)." | 7.80 | The effect of β receptor blockade through propranolol on corneal neovascularization. ( Bucak, YY; Erdurmus, M; Kükner, AŞ; Önder, Hİ; Simavli, H; Terzi, EH, 2014) |
| "To determine whether propranolol has an inhibitory effect on the angiogenesis of endometriosis in an experimental rat model or not." | 7.80 | Effects of repeated propranolol administration in a rat model of surgically induced endometriosis. ( Caydere, M; Engin-Ustun, Y; Gulerman, HC; Keskin, SM; Mollamahmutoglu, L; Moraloglu, O; Ozyer, S; Uzunlar, O, 2014) |
| "We demonstrated that propranolol reduced the incidence of arrhythmias in a rat model of myocardial infarction by coronary artery occlusion." | 7.75 | MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. ( Dong, D; Li, B; Li, X; Lu, Y; Pan, Z; Qiao, G; Shan, H; Song, W; Xu, C; Yang, B; Zhang, B; Zhang, F; Zhang, Y, 2009) |
| "Propranolol-induced hypotension is ameliorated by Intralipid infusion in this intact rabbit model." | 7.74 | Intralipid infusion ameliorates propranolol-induced hypotension in rabbits. ( Cave, GR; Harvey, MG, 2008) |
| "In this study, we evaluated the performance of dopamine beta-hydroxylase knockout (Dbh -/-) mice, which lack norepinephrine (NE), in the elevated plus maze (EPM) to examine the contribution of noradrenergic signaling to cocaine-induced anxiety." | 7.74 | Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety. ( Liles, LC; Schank, JR; Weinshenker, D, 2008) |
| "The effects of adrenergic activity and beta-blockade were studied in a canine experimental model of type-3 long QT syndrome (LQT3) induced by application of anthopleurin-A." | 7.74 | Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome. ( Ahara, S; Aizawa, Y; Chinushi, M; Furushima, H; Hosaka, Y; Iijima, K; Izumi, D; Komura, S, 2008) |
| "Heart failure (HF) may be produced by sustained beta-adrenoceptor stimulation by causing changes in the expression of endothelin-1 (ET-1), the leptin system, calcineurin and sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) underlying cardiac dysfunction." | 7.74 | Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. ( Dai, DZ; Dai, Y; Ji, H; Tang, XY; Xu, M, 2008) |
| "In this model, pretreatment with propranolol prevented the increase in portal venous inflow, which occurs following hemorrhage and volume restitution with Haemaccel." | 7.71 | Systemic and splanchnic hemodynamics following hemorrhage and volume restitution with Haemaccel in portal hypertensive rats: the effect of propranolol. ( Arish, A; Hilzenrat, N; Sikuler, E; Yaari, A, 2001) |
| "Although carvedilol attenuates left ventricular (LV) remodeling in coronary occlusion-reperfusion, it is not known whether it attenuates ischemic LV remodeling because of coronary stenosis (CS) or permanent coronary occlusion (CO)." | 7.71 | Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats. ( Maehara, K; Maruyama, Y; Sakabe, A; Yaoita, H, 2002) |
| " The purpose of this study was first to determine the arrhythmogenic properties of cromakalim in the baboon and second to determine whether N-omega-nitro-L-arginine methyl ester (L-NAME) has any effect on the induced arrhythmia." | 7.70 | The role of cromakalim and a nitric oxide synthase blocker in cardiac arrhythmia in the intact baboon model. ( Du Plooy, WJ; Hay, L; Kahler, CP; Schutte, PJ, 2000) |
| "The mechanisms of digoxin-induced ventricular arrhythmias were studied in vivo using a novel experimental model." | 7.69 | Digoxin-induced ventricular arrhythmias in the guinea pig heart in vivo: evidence for a role of endogenous catecholamines in the genesis of delayed afterdepolarizations and triggered activity. ( Hurt, CM; Pelleg, A; Xu, J, 1995) |
| "A new experimental model of acute congestive heart failure was established in open-chest dogs, and it was employed to examine the effects of dobutamine, propranolol and nitroglycerin." | 7.69 | The effects of dobutamine, propranolol and nitroglycerin on an experimental canine model of congestive heart failure. ( Kamijo, T; Kido, H; Miwa, AY; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y, 1994) |
| "Azimilide exhibited antiarrhythmic activity in several rodent models of ventricular arrhythmias." | 7.69 | Efficacy of the class III antiarrhythmic agent azimilide in rodent models of ventricular arrhythmia. ( Brooks, RR; Carpenter, JF; Maynard, AE; Miller, KE, 1996) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 7.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 7.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "All Wistar rats showed hypertension when they were given heat-stress and administered metyrapone (200 micrograms/kg/day), a cholesterol-11-beta-hydroxylase inhibitor." | 7.67 | [Hypertension in rats caused by metyrapone and heat-stress treatment]. ( Arakawa, K, 1985) |
| "The effect of timolol, propranolol, epinephrine, and isoproterenol on intraocular pressure (IOP) (measured by tonometry) were compared after topical administration in conscious rabbits." | 7.65 | Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. ( Le Douarec, JC; Plazonnet, B; Sears, ML; Silverstone, D; Stone, CA; Vareilles, P, 1977) |
| "The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer." | 5.62 | Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021) |
| "Propranolol is an ADRB2 blocker that regulates heart muscle contractions, smooth muscle relaxation, and glycogenolysis." | 5.56 | Propranolol Is an Effective Topical and Systemic Treatment Option for Experimental Epidermolysis Bullosa Acquisita. ( Bieber, K; Ghorbanalipoor, S; Gupta, Y; Hartmann, V; Kaiser, G; Kalies, K; Krause, M; Künzel, S; Ludwig, RJ; Matsumoto, K; Petersen, F; Schulze Dieckhoff, K; Stüssel, P; Veldkamp, W; Vidarsson, G; Visser, R, 2020) |
| "Propranolol is a β-adrenergic antagonist commonly used in the treatment of hypertension or acute anxiety." | 5.39 | Propranolol reduces cognitive deficits, amyloid β levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration. ( Aguirre, N; Dobarro, M; Orejana, L; Ramírez, MJ, 2013) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 5.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "Oxprenolol and carteolol were observed to have mild effects on the abnormal ECG as compared with propranolol." | 5.27 | [The abnormal ECG and the appearance of methacholine-induced arrhythmias in SART mice and effects of beta-blockers, oxprenolol, propranolol, and carteolol]. ( Harada, N; Hata, T; Itoh, E; Kita, T, 1984) |
| " This focused review emphasizes the results of clinical trials using β-blocker, losartan potassium, and irbesartan in patients with Marfan syndrome and comments briefly on mechanisms of aortic remodeling, including fibrosis and transforming growth factor β signaling." | 5.01 | Update on Clinical Trials of Losartan With and Without β-Blockers to Block Aneurysm Growth in Patients With Marfan Syndrome: A Review. ( Eagle, KA; Hofmann Bowman, MA; Milewicz, DM, 2019) |
| "Propranolol can reduce the formation of abnormal retinal neovascularization in oxygen-induced retinopathy (OIR) models, and reduce leaking, tortuous, and abnormally expanding retinal blood vessels." | 4.31 | Propranolol ameliorates retinopathy of prematurity in mice by downregulating HIF-1α via the PI3K/Akt/ERK pathway. ( Ding, Y; Liu, L; Liu, Y; Su, S; Wang, Y; Yang, G; Zhang, J; Zou, P, 2023) |
| "Resveratrol significantly decreased thermal allodynia (and not anxiety) in all experimental days." | 4.02 | Intracerebroventricular injection of propranolol blocked analgesic and neuroprotective effects of resveratrol following L ( Bahari, Z; Bahrami, F; Ghasemi, M; Hosseini, M; Iman, M; Mohammadi, MT; Zabihian, MA, 2021) |
| " We have provided experimental evidence showing the suppressive effects of the nonselective β-adrenoreceptor antagonist propranolol on hyperglycemia, inflammation, and brain injury in a rat model experiencing cerebral ischemia." | 3.96 | Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke. ( Chang, CY; Chen, CJ; Chen, WY; Kuan, YH; Liao, SL; Lin, SY; Wang, YY; Wu, CC, 2020) |
| " There are some reports have shown that curcumin, the major component of curcuma, has a good curative effect on psoriasis, but the mechanism is still unknown, so the present study was designed to investigate the effect of curcuma's extraction on psoriasis-like mouse, and to explore the mechanisms of therapy." | 3.96 | Curcuma's extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin, proliferating cell nuclear antigen and toll-like receptor expression. ( He, D; Li, JQ; She, SY; Tong, RS; Zhang, SH; Zhong, ZD, 2020) |
| "Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic blocking agents in a myocardial infarction (MI) model induced by left coronary occlusion in rats." | 3.91 | Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats. ( Araujo, IG; Império, GE; Marassi, MP; Mecawi, AS; Olivares, EL; Reis, LC; Seara, FAC; Silva, ACM, 2019) |
| "To investigate the effect of acupuncture at PC6 on cardiac hypertrophy in isoproterenol (ISO)-treated mice." | 3.91 | Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice. ( Du, Q; Guo, Y; Hou, Y; Yang, F; Zhang, M; Zhu, P, 2019) |
| "Propranolol is an approved non-selective β-adrenergic blocker that is first line therapy for infantile hemangioma." | 3.91 | R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. ( Andelfinger, G; Bischoff, J; Chiang, IK; Fontaine, F; Francois, M; Gambin, Y; Hamdan, M; Huang, L; Khosrotehrani, K; Lesieur, E; Meurer, M; Moustaqil, M; Overman, J; Pasquier, E; Patel, J; Sierecki, E; Wylie-Sears, J; Zuegg, J, 2019) |
| " We hypothesized that early and unselective beta-blockade with propranolol alone or in combination with the alfa2-agonist clonidine would decrease brain edema, blood-brain barrier permeability, and glycocalyx disruption at 24 hours after trauma." | 3.88 | Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat. ( Bentzer, P; Genét, GF; Hansen, MB; Johansson, PI; Ostrowski, SR, 2018) |
| " Results VL-102-evoked acute and chronic mechanical cephalic and hind-paw allodynia in a dose-dependent manner, which was blocked by the migraine medications sumatriptan, propranolol, and topiramate." | 3.88 | Soluble guanylyl cyclase is a critical regulator of migraine-associated pain. ( Ben Aissa, M; Bennett, BM; Bertels, Z; Gaisina, IN; Gandhi, R; Lee, SH; Litosh, V; Moye, LS; Novack, M; Pradhan, AA; Thatcher, GR; Tipton, AF; Wang, Y, 2018) |
| "Astilbin has anti-inflammatory and immunoregulatory effects, and is frequently used in prescriptions treating psoriasis; however, the mechanism remains to be fully elucidated." | 3.88 | Astilbin emulsion improves guinea pig lesions in a psoriasis-like model by suppressing IL-6 and IL-22 via p38 MAPK. ( Lu, C; Xiao, Z; Yu, J; Zhang, Y; Zhao, R, 2018) |
| "We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors." | 3.88 | Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. ( Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S, 2018) |
| "We sought to evaluate effect of propranolol in the treatment of infantile hemangiomas by quantifying the amount of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and hypoxia-inducible factor-1α (HIF-1α)." | 3.88 | Propranolol inhibits the activity of PI3K, AKT, and HIF-1α in infantile hemangiomas. ( Huang, G; Lin, H; Lin, Z; Wang, L; Wang, W, 2018) |
| " The in vivo anti-psoriasis effects of ZnPc-F7-PDT were evaluated using a mouse vagina model, a propranolol-induced cavy psoriasis model and an imiquimod (IMQ)-induced nude mouse psoriasis model." | 3.85 | Anti-Psoriasis Effects and Mechanisms of Α-(8-Quinolinoxy) Zinc Phthalocyanine-Mediated Photodynamic Therapy. ( Bao, J; Jiang, ZH; Jin, HT; Li, C; Li, WF; Liu, HQ; Wang, AP; Wang, YM; Wei, JF, 2017) |
| "Propranolol is a vasoactive drug that shows antiangiogenic and antitumour activities in melanoma." | 3.85 | Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. ( Bearzi, C; Buoncervello, M; Catalano, L; Gabriele, L; Giordani, L; Maccari, S; Macchia, D; Marano, G; Rampin, A; Rizzi, R; Spada, M; Stati, T, 2017) |
| "In this work, we evaluated the antitumor effect of metronomic treatment with a combination of two repositioned drugs, metformin and propranolol, in triple negative breast cancer models." | 3.85 | Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. ( André, N; Baglioni, M; Bondarenko, M; Carré, M; Laluce, NC; Menacho Márquez, M; Rico, M; Rozados, V; Scharovsky, OG, 2017) |
| " Using a clinically relevant rodent model of lung contusion (LC), hemorrhagic shock (HS), and chronic stress (CS), we hypothesize that daily propranolol (BB), a nonselective β blocker, restores BM function and improves iron homeostasis." | 3.85 | Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress. ( Alamo, IG; Bible, LE; Efron, PA; Kannan, KB; Loftus, TJ; Mohr, AM; Ramos, H, 2017) |
| "Propranolol could effectively inhibit the formation of retinal neovascularization in mice; the eye drops was more effective than the IP injection." | 3.83 | [Effects of propranolol on oxygen-induced retinal neovascularization in mouse]. ( Huang, X; Wang, Y; Yang, G; Yang, Z; Zhang, J, 2016) |
| "To evaluate the inhibitory effects of propranolol, a nonselective and lipophilic β-adrenergic receptor blocker, on alkali-induced corneal neovascularization (NV)." | 3.80 | The effect of β receptor blockade through propranolol on corneal neovascularization. ( Bucak, YY; Erdurmus, M; Kükner, AŞ; Önder, Hİ; Simavli, H; Terzi, EH, 2014) |
| "To determine whether propranolol has an inhibitory effect on the angiogenesis of endometriosis in an experimental rat model or not." | 3.80 | Effects of repeated propranolol administration in a rat model of surgically induced endometriosis. ( Caydere, M; Engin-Ustun, Y; Gulerman, HC; Keskin, SM; Mollamahmutoglu, L; Moraloglu, O; Ozyer, S; Uzunlar, O, 2014) |
| "Iron overload was generated by intraperitoneal injections of iron dextran (1g/kg) administered once a week for 8 weeks in male C57bl/6 mice, while propranolol was administered in drinking water at the dose of 40 mg/kg/day." | 3.79 | The C57BL/6 genetic background confers cardioprotection in iron-overloaded mice. ( Catalano, L; Corritore, E; Maccari, S; Marano, G; Massimi, A; Musumeci, M; Sestili, P, 2013) |
| " Propranolol, a nonselective β-adrenergic receptor blocker, was reported to protect against pathologic retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR)." | 3.78 | Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. ( Chen, J; Hatton, CJ; Hellstrom, A; Hurst, CG; Joyal, JS; Juan, AM; Pei, DT; Smith, LE; Stahl, A; Xu, D, 2012) |
| "Droxidopa might be an effective therapeutic agent for hemodynamic and renal alterations of liver cirrhosis and should be tested in cirrhosis patients." | 3.78 | Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats. ( Augustin, S; Brull, A; Coll, M; Esteban, R; Ezkurdia, N; Genescà, J; Guardia, J; Martell, M; Raurell, I; Rodriguez, S, 2012) |
| " The ACR, LS, and CS were compared with those by sonomicrometry at baseline and during pharmacological stress tests (dobutamine and propranolol infusion) and acute myocardial ischemia induced by occlusion of mid-left ascending artery." | 3.77 | Endocardial surface area tracking for assessment of regional LV wall deformation with 3D speckle tracking imaging. ( Aonuma, K; Enomoto, Y; Ishizu, T; Seo, Y; Sugimori, H, 2011) |
| "We demonstrated that propranolol reduced the incidence of arrhythmias in a rat model of myocardial infarction by coronary artery occlusion." | 3.75 | MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection. ( Dong, D; Li, B; Li, X; Lu, Y; Pan, Z; Qiao, G; Shan, H; Song, W; Xu, C; Yang, B; Zhang, B; Zhang, F; Zhang, Y, 2009) |
| " Thirty-six Langendorff-perfused rabbit hearts were used to analyze the effects of the Na(+)/Ca(2+) exchanger blocker KB-R7943, propranolol, and the adenosine A(2) receptor antagonist SCH-58261 on the acceleration of ventricular fibrillation (VF) produced by acute myocardial stretching." | 3.75 | Pharmacological modifications of the stretch-induced effects on ventricular fibrillation in perfused rabbit hearts. ( Alberola, A; Cánoves, J; Chorro, FJ; Cinca, J; Hove-Madsen, L; Mainar, L; Pelechano, F; Such, L; Such-Miquel, L; Tormos, A; Trapero, I, 2009) |
| "Propranolol-induced hypotension is ameliorated by Intralipid infusion in this intact rabbit model." | 3.74 | Intralipid infusion ameliorates propranolol-induced hypotension in rabbits. ( Cave, GR; Harvey, MG, 2008) |
| "3 to 30 mg/kg), a new anticonvulsant drug, in a model of essential tremor in comparison to the reference compounds propranolol and primidone." | 3.74 | Lacosamide, the new anticonvulsant, effectively reduces harmaline-induced tremors in rats. ( Freitag, J; Lekieffre, D; Stöhr, T, 2008) |
| " We hypothesized that CPU86017, derived from berberine, which possesses multi-channel blocking activity, could suppress inflammatory factors, resulting in inhibition of over-expression of ether-a-go-go (ERG) and an augmented incidence of ventricular fibrillation (VF) in ischaemia/reperfusion (I/R)." | 3.74 | Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent. ( Dai, DZ; Dai, Y; Du, RH; Tang, WH; Yi, HW, 2008) |
| "In this study, we evaluated the performance of dopamine beta-hydroxylase knockout (Dbh -/-) mice, which lack norepinephrine (NE), in the elevated plus maze (EPM) to examine the contribution of noradrenergic signaling to cocaine-induced anxiety." | 3.74 | Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety. ( Liles, LC; Schank, JR; Weinshenker, D, 2008) |
| "The effects of adrenergic activity and beta-blockade were studied in a canine experimental model of type-3 long QT syndrome (LQT3) induced by application of anthopleurin-A." | 3.74 | Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome. ( Ahara, S; Aizawa, Y; Chinushi, M; Furushima, H; Hosaka, Y; Iijima, K; Izumi, D; Komura, S, 2008) |
| "The results provide no evidence that the beta-blocker propranolol may stimulate bone formation, and do not justify its use for clinical treatment of osteoporosis." | 3.74 | A trial study of propranolol and Zhigancao decoction on the central depressant and anti-osteoporosic action in ovariectomized rats. ( Guo, Y; Ishida, T; Kanehara, M; Murakami, T; Nakazawa, H; Takeda, A; Urata, S; Zhang, W; Zhang, Y, 2008) |
| "Heart failure (HF) may be produced by sustained beta-adrenoceptor stimulation by causing changes in the expression of endothelin-1 (ET-1), the leptin system, calcineurin and sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) underlying cardiac dysfunction." | 3.74 | Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. ( Dai, DZ; Dai, Y; Ji, H; Tang, XY; Xu, M, 2008) |
| " The elevated ST segments of electrocardiogram (ECG), cardiac arrhythmias, and ratio of infarct size/risk zone were compared among the normal control (NC), ischemia and reperfusion (IR), electro-acupuncture (EA), electro-acupuncture plus propranolol (EAP), and EA at nonacupoint (EAN) groups." | 3.73 | A preliminary study on the cardioprotection of acupuncture pretreatment in rats with ischemia and reperfusion: involvement of cardiac beta-adrenoceptors. ( Fu, W; Gao, J; Jin, Z; Yu, X, 2006) |
| "The beta1-selective blocker metoprolol was effective to prevent coronary vasospasm." | 3.73 | Differing effects of metoprolol and propranolol on large vessel and microvessel responsiveness in a porcine model of coronary spasm. ( Aikawa, K; Ishibashi, T; Maruyama, Y; Matsumoto, K; Muto, M; Onogi, F; Osugi, T; Saitoh, S, 2006) |
| "In this model, pretreatment with propranolol prevented the increase in portal venous inflow, which occurs following hemorrhage and volume restitution with Haemaccel." | 3.71 | Systemic and splanchnic hemodynamics following hemorrhage and volume restitution with Haemaccel in portal hypertensive rats: the effect of propranolol. ( Arish, A; Hilzenrat, N; Sikuler, E; Yaari, A, 2001) |
| "Although carvedilol attenuates left ventricular (LV) remodeling in coronary occlusion-reperfusion, it is not known whether it attenuates ischemic LV remodeling because of coronary stenosis (CS) or permanent coronary occlusion (CO)." | 3.71 | Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats. ( Maehara, K; Maruyama, Y; Sakabe, A; Yaoita, H, 2002) |
| " The purpose of this study was first to determine the arrhythmogenic properties of cromakalim in the baboon and second to determine whether N-omega-nitro-L-arginine methyl ester (L-NAME) has any effect on the induced arrhythmia." | 3.70 | The role of cromakalim and a nitric oxide synthase blocker in cardiac arrhythmia in the intact baboon model. ( Du Plooy, WJ; Hay, L; Kahler, CP; Schutte, PJ, 2000) |
| "The effect of adrenoceptor blockers on nicotine induced hyperglycemia were studied in fasted normal and thyroidectomised rats." | 3.70 | Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats. ( Fasanmade, AA; Ogwumike, OO, 2000) |
| "The mechanisms of digoxin-induced ventricular arrhythmias were studied in vivo using a novel experimental model." | 3.69 | Digoxin-induced ventricular arrhythmias in the guinea pig heart in vivo: evidence for a role of endogenous catecholamines in the genesis of delayed afterdepolarizations and triggered activity. ( Hurt, CM; Pelleg, A; Xu, J, 1995) |
| "A new experimental model of acute congestive heart failure was established in open-chest dogs, and it was employed to examine the effects of dobutamine, propranolol and nitroglycerin." | 3.69 | The effects of dobutamine, propranolol and nitroglycerin on an experimental canine model of congestive heart failure. ( Kamijo, T; Kido, H; Miwa, AY; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y, 1994) |
| "All animals of group 2 (which received propranolol orally and in addition intradermal injections of adjuvant) developed psoriasiform epidermal hyperplasia with acanthosis." | 3.69 | Induction of psoriasiform changes in guinea pig skin by propranolol. ( Brenner, S; Shechter, H; Wolf, R, 1994) |
| " Garlic dialysate suppressed premature ventricular contractions (PVC) and ventricular tachycardia (VT) in ouabain-intoxicated dogs as well as the ectopic rhythms induced by isoprenaline (10(-6) M) and aconitine (10(-8) M) on electrically driven left rat atria." | 3.69 | Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations. ( Bardisa, L; Martín, N; Pantoja, C; Quezada, P; Valenzuela, J; Vargas, M, 1994) |
| "Azimilide exhibited antiarrhythmic activity in several rodent models of ventricular arrhythmias." | 3.69 | Efficacy of the class III antiarrhythmic agent azimilide in rodent models of ventricular arrhythmia. ( Brooks, RR; Carpenter, JF; Maynard, AE; Miller, KE, 1996) |
| " At a final experiment, acute cardiac failure was induced by administration of propranolol." | 3.69 | Hemodynamic effects of different pacing ratios in chronic dynamic double cardiomyoplasty. ( Earle, NR; Glaeser, DH; Hartley, CJ; Lawrie, GM; Li, Z; Michael, LH; Soltero, ER, 1996) |
| "Administration of propranolol can provoke bronchoconstriction in asthmatic patients." | 3.69 | Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs. ( Fujimura, M; Matsuda, T; Myou, S; Songür, N; Tsujiura, M, 1996) |
| " Eight anesthetized open chest dogs suffering from atrial fibrillation and heart failure, obtained by topic acetylcholine and propranolol, were treated by a cardiomyoplasty procedure performed with an electrostimulated latissimus dorsi muscle flap (LDMF)." | 3.69 | Hemodynamic effects of cardiomyoplasty in an experimental model of acute heart failure and atrial fibrillation. ( Cabrera Fischer, EI; Carpentier, A; Chachques, JC; Christen, AI; Risk, MR, 1996) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 3.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "The anti-asthmatic effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a specific thromboxane A2 (TXA2) synthase inhibitor, were investigated in the ovalbumin-sensitized guinea pig asthmatic model." | 3.68 | Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response. ( Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Terada, A; Yamaguchi, T, 1993) |
| ") of 13 tended to decrease left ventricular end-diastolic pressure (LVEDP) in a propranolol-induced heart failure model (dogs) and showed a potent protective effect against reperfusion arrhythmia in rats." | 3.68 | 1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives. ( Hayashi, H; Ikeda, J; Kubo, K; Kuroda, T; Sano, T; Suzuki, F, 1993) |
| "After chronic administration of propranolol (1 and 5 mg/kg, 14 days) to rats time-course of forced swimming changed with the decrease of rhythmical index of depression." | 3.68 | [The antidepressive properties of anaprilin]. ( Arushanian, EB; Beĭer, EV, 1992) |
| "The aim was to evaluate in a minipig model of acute myocardial infarction the cardioprotection provided by the beta adrenoceptor blocking and vasodilating activities present in carvedilol; comparison was made to the pure beta adrenoceptor antagonist, propranolol." | 3.68 | Cardioprotective effects of carvedilol, a novel beta adrenoceptor antagonist with vasodilating properties, in anaesthetised minipigs: comparison with propranolol. ( Bril, A; DiMartino, MJ; Feuerstein, GZ; Linee, P; Poyser, RH; Ruffolo, RR; Slivjak, M; Smith, EF, 1992) |
| "The efficacy of a controlled-release topical dosage form of glyceryl trinitrate (Nitroglycerin Transdermal Therapeutic System, Nitroderm TTS, NTG-TTS; CAS 55-63-0) was studied in the experimental model of congestive heart failure in beagles." | 3.68 | Efficacy of the glyceryl trinitrate transdermal therapeutic system in a dog model of heart failure. ( Inukai, T; Katahira, J; Nakao, K; Tanaka, M, 1991) |
| " Serum angiotensin converting enzyme activity (ACEA) and plasma renin activity (PRA) were determined in rats under different experimental conditions such as: nephrotic syndrome (NS), bilateral nephrectomy (BN), renovascular hypertension (RH), dehydration (DEH), anaesthesia (AN), low sodium diet (LSD) and high sodium diet (HSD), and injection with propranolol (PRO) and isoprenaline (ISO)." | 3.68 | Serum angiotensin converting enzyme activity and plasma renin activity in experimental models of rats. ( Cruz, C; Ibarra-Rubio, ME; Pedraza-Chaverrí, J; Peña, JC; Tapia, E, 1990) |
| "The effects of rilmenidine [(N-dicyclopropylmethyl) amino-2-oxazoline; S 3341], an alpha 2 agonist, on the hypertensive rat heart have been compared with those of propranolol, using a model of deoxycorticosterone acetate (DOCA)-salt hypertension." | 3.67 | Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine. ( Callens-el Amrani, F; Paolaggi, F; Swynghedauw, B, 1989) |
| "To determine the relationship between hepatic glucose clearance and elevated epinephrine levels in sepsis, dogs with gangrenous cholecystitis were anesthetized and received either propranolol hydrochloride (mean dose, 0." | 3.67 | Beta-adrenergic blockade increases the hepatic extraction of glucose in sepsis. ( Caruana, JA; Chen, HH; Maben, WC; Whalen, DA, 1986) |
| "Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration." | 3.67 | Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death. ( Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL, 1986) |
| "Latex-induced transmural myocardial infarction or epicardial application of phenol interrupts sympathetic fibers innervating myocardium apical to the infarction or to the phenol-painted area." | 3.67 | Results of sympathetic denervation in the canine heart: supersensitivity that may be arrhythmogenic. ( Inoue, H; Zipes, DP, 1987) |
| "All Wistar rats showed hypertension when they were given heat-stress and administered metyrapone (200 micrograms/kg/day), a cholesterol-11-beta-hydroxylase inhibitor." | 3.67 | [Hypertension in rats caused by metyrapone and heat-stress treatment]. ( Arakawa, K, 1985) |
| "Ventricular arrhythmias due to myocardial infarct were produced in 14 dogs, and the antiarrhytmic effects of quinidine (Qd), lidocaine (Lid), aprindine (Apr), and dl-propranolol (dl-Prop) were investigated." | 3.66 | [Effects of antiarrhythmic agents on ventricular arrhythmias following myocardial infarct induced with glass beads in dogs (author's transl)]. ( Haruna, M; Kimoto, S; Nakao, T; Ueda, M, 1981) |
| "The effect of timolol, propranolol, epinephrine, and isoproterenol on intraocular pressure (IOP) (measured by tonometry) were compared after topical administration in conscious rabbits." | 3.65 | Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. ( Le Douarec, JC; Plazonnet, B; Sears, ML; Silverstone, D; Stone, CA; Vareilles, P, 1977) |
| "The effects of electrical stimulation of the vagus nerves and the administration of atropine on ventricular fibrillation threshold (VFT) were studied in open-chest hearts of 15 dogs anesthetized by alpha-chloralose." | 3.65 | Effects of vagal stimulation, atropine, and propranolol on fibrillation threshold of normal and ischemic ventricles. ( Han, J; Rogers, R; Tse, WW; Yoon, MS, 1977) |
| "Posttraumatic stress disorder (PTSD) has been described as the only neuropsychiatric disorder with a known cause, yet effective behavioral and pharmacotherapies remain elusive for many afflicted individuals." | 2.53 | Revisiting propranolol and PTSD: Memory erasure or extinction enhancement? ( Fitzgerald, PJ; Giustino, TF; Maren, S, 2016) |
| "Isoproterenol signaling was inhibited by administration of propranolol." | 1.91 | Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer. ( Drage, MG; Fleming, FJ; Garrett-Larsen, J; Gavras, NW; Gerber, SA; Gradzewicz, LB; Johnston, CJ; Kintzel, SA; Lesch, ML; Linehan, DC; Lord, EM; Love, TMT; Mills, BN; Murphy, JD; Qiu, H; Repasky, EA; Uccello, TP; Ullman, NA; Velagaleti, T; Ye, J, 2023) |
| "Propranolol has shown clinical benefit in head injuries; however, the underlying mechanism is also unknown." | 1.91 | Propranolol Reduces p-tau Accumulation and Improves Behavior Outcomes in a Polytrauma Murine Model. ( Collins, SM; England, LG; Goodman, MD; McGlone, ED; Morris, MC; Robson, MJ; Schuster, RM; Singer, KE; Wallen, TE, 2023) |
| "Brain edema was determined by hemispheric wet-to-dry ratios." | 1.72 | Beta blockade in TBI: Dose-dependent reductions in BBB leukocyte mobilization and permeability in vivo. ( Ahmed, S; Culkin, MC; ElSaadani, M; Georges, A; Jacovides, CL; Kaplan, LJ; Kumar, MA; Lopez, AJ; Pascual, JL; Smith, DH, 2022) |
| "Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg." | 1.72 | MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022) |
| "Propranolol treatment abrogated the elaboration of inflammatory cytokine mRNA expression in the brain instigated in our model, having no treatment effects in non-DFP exposed groups." | 1.62 | The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness. ( Kelly, KA; Michalovicz, LT; Miller, DB; O'Callaghan, JP; Sullivan, K, 2021) |
| "Pretreatment with propranolol or nor-BNI prior to restraint stress prevented both transient cutaneous allodynia and priming, demonstrated by a lack of umbellulone-induced cutaneous allodynia." | 1.62 | A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain. ( Chessell, IP; Dodick, DW; Kopruszinski, CM; Navratilova, E; Porreca, F; Swiokla, J, 2021) |
| "The multistep process of oral carcinogenesis provides a biological rationale for the use of chemoprevention in individuals at increased risk of developing oral cancer." | 1.62 | Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study. ( Carrard, VC; Castilho, RM; Gaio, EJ; Nör, F; Rösing, CK; Spuldaro, TR; Wagner, VP, 2021) |
| "Amitriptyline-induced lower post-TBI HR and improved functional outcomes without affecting inflammatory response." | 1.62 | Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. ( Earnest, R; Goodman, MD; McGlone, E; Morris, MC; Singer, KE; Stevens-Topie, S; Wallen, TE, 2021) |
| "A mouse model of endometriosis recurrence caused by spillage and dissemination was first established using 24 female Balb/c mice." | 1.62 | Preoperative and perioperative intervention reduces the risk of recurrence of endometriosis in mice caused by either incomplete excision or spillage and dissemination. ( Chen, Y; Guo, SW; Liu, X, 2021) |
| "Cardiogenic shock was induced in healthy pigs with a bolus of 0." | 1.56 | Use of a Porcine Model to Evaluate the Risks and Benefits of Vasopressors in Propranolol Poisoning. ( Cole, JB; Corcoran, JN; Engebretsen, KM; Stellpflug, SJ, 2020) |
| "Propranolol is an ADRB2 blocker that regulates heart muscle contractions, smooth muscle relaxation, and glycogenolysis." | 1.56 | Propranolol Is an Effective Topical and Systemic Treatment Option for Experimental Epidermolysis Bullosa Acquisita. ( Bieber, K; Ghorbanalipoor, S; Gupta, Y; Hartmann, V; Kaiser, G; Kalies, K; Krause, M; Künzel, S; Ludwig, RJ; Matsumoto, K; Petersen, F; Schulze Dieckhoff, K; Stüssel, P; Veldkamp, W; Vidarsson, G; Visser, R, 2020) |
| "Atropine has also shown to disrupt memory formation." | 1.56 | Blockade of muscarinic receptors impairs reconsolidation of older fear memory by decreasing cholinergic neurotransmission: A study in rat model of PTSD. ( Batool, Z; Haider, S; Liaquat, L; Rafiq, S, 2020) |
| "In an orthotopic murine model of pancreatic cancer, AES-135 prolongs survival significantly, therefore representing a candidate for further preclinical testing." | 1.51 | Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. ( Adile, AA; Bakhshinyan, D; Berger-Becvar, A; de Araujo, ED; Deininger, MW; Fishel, ML; Gawel, JM; Geletu, M; Grimard, ML; Gunning, PT; Heaton, WL; Konieczny, SF; Luchman, HA; O'Hare, T; Raouf, YS; Shah, F; Shouksmith, AE; Singh, SK; Venugopal, C; Weiss, S, 2019) |
| "β-blockers have been shown to improve survival after traumatic brain injury (TBI); however, the impact of continuous dosage of β-blockers on cognitive function has not been elucidated." | 1.51 | Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury. ( Bae, EH; Friese, RS; Gries, L; Hamidi, M; Hanna, K; Joseph, B; Kulvatunyou, N; OʼKeeffe, T; Tang, A; Zakaria, ER; Zeeshan, M, 2019) |
| "Propranolol was administered at 1 h post-TBI." | 1.51 | Propranolol protects cerebral autoregulation and reduces hippocampal neuronal cell death through inhibition of interleukin-6 upregulation after traumatic brain injury in pigs. ( Armstead, WM; Vavilala, MS, 2019) |
| " In contrast, in Study 2 in which the timing and dosage of propranolol (0." | 1.51 | Voluntary exercise or systemic propranolol ameliorates stress-related maladaptive behaviors in female rats. ( Aldrich, SJ; Cahill, MM; Christ, CC; Robinson, S; Taylor-Yeremeeva, E, 2019) |
| "Background Migraine is a highly prevalent and disabling disorder of the brain with limited therapeutic options, particularly for preventive treatment." | 1.48 | Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation. ( Akerman, S; Goadsby, PJ; Martins-Oliveira, M; Zhao, Y, 2018) |
| "Post-traumatic stress disorder (PTSD) is a common consequence of exposure to a life-threatening event." | 1.48 | Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment. ( Benkahoul, A; Birmes, P; Ferry, B; Roullet, P; Villain, H, 2018) |
| "Post-traumatic stress disorder (PTSD) is a learning-based anxiety disorder with significant public health challenges due to difficulties in treating the complex, multiple symptomology." | 1.48 | Propranolol produces short-term facilitation of extinction in a rabbit model of post-traumatic stress disorder. ( Burhans, LB; Schreurs, BG; Smith-Bell, CA, 2018) |
| "The propranolol +2DG treatment efficiently prevents prostate cancer cell proliferation, induces cell apoptosis, alters mitochondrial morphology, inhibits mitochondrial bioenergetics and aggravates ER stress in vitro and also suppresses tumor growth in vivo." | 1.48 | Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression. ( Brohée, L; Castronovo, V; Colige, AC; Deroanne, CF; Nusgens, B; Peulen, O; Thiry, M, 2018) |
| "Stroke was induced in mice by middle cerebral artery occlusion for 90 minutes, followed by reperfusion." | 1.46 | Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice. ( Berressem, D; Eckert, GP; Klein, J; Koch, K; Konietzka, J; Thinnes, A, 2017) |
| "Propranolol was shown to reduce CO2 production in an experimental DISSUB model in humans but its effects on DCS in a DISSUB rescue scenario are unknown." | 1.46 | Propranolol Effects on Decompression Sickness in a Simulated DISSUB Rescue in Swine. ( Cronin, WA; Forbes, AS; Hall, AA; Mahon, RT; Regis, DP, 2017) |
| "In propranolol-pretreated cats during S1 or S2 stimulation, MTEP (3 mg/kg) significantly (p < 0." | 1.46 | Neurotransmitter Mechanisms Underlying Sacral Neuromodulation of Bladder Overactivity in Cats. ( Bandari, J; Bansal, U; Chang, V; de Groat, WC; Lamm, V; Roppolo, JR; Shen, B; Tai, C; Wang, J; Zhang, Z, 2017) |
| "Background The development of novel migraine therapies has been slow, in part because of the small number of clinically relevant animal models." | 1.43 | The effects of acute and preventive migraine therapies in a mouse model of chronic migraine. ( Charles, A; McGuire, B; Pradhan, AA; Tarash, I; Tipton, AF, 2016) |
| " The bioavailability of IGF-1 at both mRNA and protein levels were measured by quantitative real-time PCR and Western blot respectively." | 1.43 | Decrease of the insulin-like growth factor-1 bioavailability in spontaneously hypertensive rats with erectile dysfunction. ( Cheng, SP; Huang, H; Huang, JB; Liu, RH; Mao, FJ; Pan, H; Sun, YL; Xiao, S; Zhong, GJ; Zhou, ZY, 2016) |
| "In this study, three seizure models, including intravenous pentylenetetrazole (PTZ), intraperitoneal PTZ and electroshock, were examined in mice." | 1.43 | The interaction between morphine and propranolol in chemical and electrical seizure models of mice. ( Fakhrzad, A; Khosravani, E; Moezi, L; Shafaroodi, H, 2016) |
| "Due to the complex nature of Alzheimer's disease, multi-target-directed ligand approaches are one of the most promising strategies in the search for effective treatments." | 1.42 | Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. ( Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K, 2015) |
| "Propranolol is a non-selective β-blocker that is recommended for the treatment of PH." | 1.42 | Comparative portal hypotensive effects as propranolol of vitamin D₃ treatment by decreasing intrahepatic resistance in cirrhotic rats. ( Hsieh, YC; Lee, KC; Lee, PC; Lee, TY; Lee, WP; Lin, HC; Yang, YY, 2015) |
| "Propranolol treatment also significantly (P = 0." | 1.42 | Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats. ( de Groat, WC; Rogers, MJ; Roppolo, JR; Schwen, Z; Shen, B; Tai, C; Wang, J; Xiao, Z, 2015) |
| "Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant." | 1.42 | Effect of propranolol on capsular reaction around silicone implants in guinea pigs. ( Guimarães, SB; Leite Filho, JA; Leite, JA; Maciel, FS; Mesquita, CJ; Rocha, JL, 2015) |
| " Chronic dosing of propranolol may be required for efficacy; therefore, we tested the efficacy of chronic treatment with either propranolol or phenytoin on RTT mice." | 1.42 | Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. ( Glaze, DG; Herrera, JA; Kaufmann, WE; Neul, JL; Percy, AK; Pitcher, MR; Skinner, S; Ward, CS; Wehrens, XH, 2015) |
| "Determine the safe dose of intravitreal propranolol (IVP), and evaluate its inhibitory effect on laser-induced choroidal neovascularization (CNV)." | 1.42 | Ocular Safety of Intravitreal Propranolol and Its Efficacy in Attenuation of Choroidal Neovascularization. ( Ahmadieh, H; Aldavood, SJ; Daftarian, N; Darjatmoko, SR; Gurel, Z; Kaharkaboudi, A; Lavine, JA; Nourinia, R; Rezaei Kanavi, M; Safi, S; Sheibani, N; Taghavi, SI; Wang, S, 2015) |
| "The aim of this study was to present a deductive compartment pharmacokinetic (PK) model to predict the concentration profiles of drugs in plasma and peritoneal fluid in peritoneal dialysis (PD) rats." | 1.40 | Effects of peritoneal dialysis on pharmacotherapy: a deductive pharmacokinetic-model approach to predict drug concentration profiles in plasma and peritoneal fluid. ( Aiba, T; Horiuchi, M; Kurosaki, Y; Moriyama, S; Takahata, Y, 2014) |
| "Rats with cerebral ischemia developed higher blood glucose, and insulin levels, and insulin resistance index, as well as hepatic gluconeogenic enzyme expression compared with the sham-treated group." | 1.40 | Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. ( Chen, CJ; Chuang, YH; Lin, SY; Sheu, WH; Tung, KC; Wang, YY, 2014) |
| "Pretreatment with propranolol and metoprolol improved survival to 90% and 100% respectively, compared with 60% in the ISO group, but did not reduce the incidence and extent of akinesis or the structural damage." | 1.40 | Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy. ( Dai, W; Kloner, RA; Sachdeva, J, 2014) |
| " Standard recommendations for dosing of insulin vary and the optimal dose of HDI in PICS has not been established." | 1.39 | A blinded, randomized, controlled trial of three doses of high-dose insulin in poison-induced cardiogenic shock. ( Adams, AB; Anderson, CP; Cole, JB; Ellsworth, H; Engebretsen, KM; Holger, JS; Stellpflug, SJ, 2013) |
| "Propranolol, at a lower dose than that used as antihypertensive (5 mg/kg, 6 wk), attenuated cognitive impairments shown by Tg2576 mice aged 9 months in the novel object recognition and fear conditioning tests." | 1.39 | Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice. ( Dobarro, M; Gerenu, G; Ramírez, MJ, 2013) |
| "Propranolol is a β-adrenergic antagonist commonly used in the treatment of hypertension or acute anxiety." | 1.39 | Propranolol reduces cognitive deficits, amyloid β levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration. ( Aguirre, N; Dobarro, M; Orejana, L; Ramírez, MJ, 2013) |
| "Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease leading to cirrhosis and cholangiocellular carcinoma." | 1.39 | Telmisartan plus propranolol improves liver fibrosis and bile duct proliferation in the PSC-like Abcb4-/- mouse model. ( Demir, M; Dienes, HP; Goeser, T; Hunt, H; Mende, S; Nierhoff, D; Odenthal, M; Pryymachuck, G; Quasdorff, M; Schulte, S; Steffen, HM; Strack, I; Töx, U, 2013) |
| "Propranolol-treated mice demonstrated a 50% reduction in laser-induced CNV." | 1.39 | Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. ( Ip, MS; Lavine, JA; Sang, Y; Sheibani, N; Wang, S, 2013) |
| " Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique." | 1.38 | Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012) |
| "Local NE produced premature ventricular complexes (PVCs) from the injection site that were dose-dependent (low-dose [30-60 μmol/L], 0." | 1.38 | Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. ( Bers, DM; Kang, C; Myles, RC; Ripplinger, CM; Wang, L, 2012) |
| "Propranolol treatment did not affect the acute or chronic elevation of corticosterone, the decrease in body weight gain, or adrenal hypertrophy observed in animals exposed to stress." | 1.38 | Fear conditioning can contribute to behavioral changes observed in a repeated stress model. ( Camp, RM; Johnson, JD; Kalburgi, SN; Porterfield, VM; Remus, JL, 2012) |
| "Villous injury and lung injury were graded histologically by a blinded reader." | 1.38 | Is the sympathetic system involved in shock-induced gut and lung injury? ( Alzate, WD; Baranski, GM; Cook, KM; Livingston, DH; Mohr, AM; Sifri, ZC, 2012) |
| " Studies were undertaken using an in situ-perfused rat liver and multiple indicator dilution, and outflow data were analyzed with a physiologically based organ pharmacokinetic model." | 1.37 | Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Thorling, CA; Zhang, Q, 2011) |
| "Propranolol was administered subcutaneously and picropodophyllin (PPP) intraperitoneally." | 1.37 | Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade. ( Bagnoli, P; Cammalleri, M; Dal Monte, M; Filippi, L; Fiorini, P; Fortunato, P; la Marca, G; Martini, D; Ristori, C, 2011) |
| "Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmic syndrome caused by mutations in genes encoding the calcium-regulation proteins cardiac ryanodine receptor (RyR2) or calsequestrin-2 (CASQ2)." | 1.37 | Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation. ( Alcalai, R; Arad, M; Berul, CI; Konno, T; Planer, D; Seidman, CE; Seidman, JG; Wakimoto, H; Wang, L, 2011) |
| "When tumors reached 100 mm, mice were treated with CpG-C/vehicle, and 24 hours later the tumor was excised along with P+E/vehicle treatment." | 1.37 | Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses. ( Ben-Eliyahu, S; Benish, M; Goldfarb, Y; Levi, B; Melamed, R; Sorski, L, 2011) |
| "Propranolol (10 mg/kg) was given once the mean arterial blood pressure>80 mm Hg and subsequent doses were given daily (LC/HS/BB)." | 1.37 | Does beta blockade postinjury prevent bone marrow suppression? ( Alzate, WD; ElHassan, IO; Hannoush, EJ; Livingston, DH; Mohr, AM; Offin, MD; Rameshwar, P; Sifri, ZC, 2011) |
| "Propranolol treatment enhances cell cycle-related gene expression in pressure overloaded hearts by increasing the number of cycling non-cardiomyocyte cells." | 1.37 | Propranolol enhances cell cycle-related gene expression in pressure overloaded hearts. ( Ambrosio, C; Catalano, L; Colledge, WH; Grace, AA; Maccari, S; Marano, G; Molinari, P; Musumeci, M; Sestili, P; Signore, M; Stati, T, 2011) |
| "Portal hypertension was induced by PVL (portal vein ligation) in Sprague-Dawley rats." | 1.37 | Propranolol modulates the collateral vascular responsiveness to vasopressin via a G(α)-mediated pathway in portal hypertensive rats. ( Chang, CC; Chuang, CL; Huang, HC; Huo, TI; Lee, FY; Lee, JY; Lee, SD; Lin, HC; Wang, SS, 2011) |
| "Propranolol (10 mg/kg) was given either prior to or immediately after HS." | 1.37 | Beta-blockade prevents hematopoietic progenitor cell suppression after hemorrhagic shock. ( Alzate, WD; Elhassan, IO; Hannoush, EJ; Jones, E; Livingston, DH; Mohr, AM; Rameshwar, P; Sifri, ZC, 2011) |
| "Propranolol is a non-selective β adrenergic receptor blocker which antagonises the anti-inflammatory effect of non-steroidal anti-inflammatory drugs via the β1 and β2 adrenergic receptors." | 1.37 | Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats. ( Akcay, F; Albayrak, Y; Karatay, S; Polat, B; Saglam, MB; Suleyman, H; Uslu, T; Yildirim, K, 2011) |
| "In Parkinson's disease (PD), the long term use of L-DOPA results in major adverse effects including dyskinesia or abnormal involuntary movements." | 1.36 | The selective alpha1 adrenoceptor antagonist HEAT reduces L-DOPA-induced dyskinesia in a rat model of Parkinson's disease. ( Buck, K; Ferger, B, 2010) |
| "Treatment with propranolol prevented the increased cAMP/PKA in 1 h MI, whereas propranolol had little effect on decreased cAMP/PKA in 3 months MI." | 1.36 | Propranolol regulates cardiac transient outward potassium channel in rat myocardium via cAMP/PKA after short-term but not after long-term ischemia. ( Cao, YX; Hong, Y; Liu, Y; Lu, YJ; Shan, HL; Xu, CQ; Yang, BF; Zhang, JL; Zhang, L; Zhao, M, 2010) |
| "Periodontal disease is characterised by alveolar bone loss." | 1.36 | Blockade of sympathetic b-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model. ( Hamada, N; Kim, Y; Okada, Y; Ozono, S; Sasaguri, K; Sato, S; Takahashi, Y, 2010) |
| "Propranolol pretreatment blunted the initial decrease in blood glutamate, and thereafter had no effect when compared with control and treatment groups." | 1.36 | The effect of hyperthermia on blood glutamate levels. ( Artru, AA; Dubilet, M; Gruenbaum, SE; Gurevich, B; Leibowitz, A; Ohayon, S; Shaked, G; Shapira, Y; Teichberg, VI; Zlotnik, A, 2010) |
| "Propranolol treatment also had no effects on these outcomes." | 1.35 | Blockade of adrenoreceptors inhibits the splenic response to stroke. ( Ajmo, CT; Collier, LA; Cuevas, J; Green, SM; Hall, AA; Leonardo, CC; Pennypacker, KR; Willing, AE; Womble, TA, 2009) |
| "Propranolol hydrochloride was injected in 1 group during the tracer infusion to decrease heart rate, and the other group without propranolol injection served as a control." | 1.35 | Acute propranolol infusion stimulates protein synthesis in rabbit skin wound. ( Aarsland, A; Chinkes, DL; Finnerty, CC; Herndon, DN; Jeschke, MG; Meng, C; Zhang, XJ, 2009) |
| "Obesity is associated with endothelial dysfunction and inflammation." | 1.35 | Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism. ( Fagan, K; Frye, M; McMurtry, I; Orton, EC, 2009) |
| "In the anesthetized guinea pig, arrhythmias are induced by a slow intravenous infusion of digoxin, which provokes extrasystoles, ventricular tachyarrhythmias, and ultimately cardiac arrest." | 1.35 | Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig. ( Guillaume, P; Lacroix, P; Provost, D, 2009) |
| "Treatment with risperidone for 8 weeks, but not 2 or 4 weeks, significantly improved working memory performance." | 1.34 | Propranolol blocks chronic risperidone treatment-induced enhancement of spatial working memory performance of rats in a delayed matching-to-place water maze task. ( Dawe, GS; Lim, EP; Nagarajah, R; Verma, V, 2007) |
| " Additional mechanisms involving blockade of Ca2+ entry in the vascular smooth muscle and increase in NO bioavailability contributes to beneficial effects of long-term propranolol treatment." | 1.34 | Vascular effects of long-term propranolol administration after chronic nitric oxide blockade. ( Antunes, E; Claudino, MA; De Nucci, G; Priviero, FB; Teixeira, CE; Zanesco, A, 2007) |
| "Essential tremor is the most common movement disorder and has an unknown etiology." | 1.33 | Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. ( Breese, GR; Criswell, HE; Hamre, K; Homanics, GE; Kralic, JE; Matthews, DB; Morrow, AL; O'Buckley, TK; Osterman, JL; Wilkie, ME, 2005) |
| "Ventricular fibrillation was untreated for 7 minutes before the start of precordial compression, mechanical ventilation, and attempted defibrillation." | 1.32 | Evidence favoring the use of an alpha2-selective vasopressor agent for cardiopulmonary resuscitation. ( Checchia, P; Pellis, T; Song, L; Sun, S; Tang, W; Weil, MH; Xie, J, 2003) |
| "To investigate the mechanism responsible for the increased bioavailability of propranolol in bilateral ureter-ligated (BUL) rats, the intestinal absorption and hepatic extraction of propranolol and metoprolol were evaluated." | 1.32 | Intestinal absorption and hepatic extraction of propranolol and metoprolol in rats with bilateral ureteral ligation. ( Hashimoto, Y; Higashi, T; Ohta, T; Okabe, H, 2004) |
| "Hemorrhagic shock is associated with increasing catecholamine plasma concentrations." | 1.31 | Influence of beta-adrenoceptor antagonists on hemorrhage-induced cellular immune suppression. ( Nickel, E; Oberbeck, R; Pape, HC; Tschernig, T; van Griensven, M; Wittwer, T, 2002) |
| "In experiments involving simulation of ischemic heart disease in adult rabbits, morphofunctional aspects were studied of cardioprotective action of propranolol on the contractile myocardium." | 1.31 | [Morphofunctional aspects of cardioprotective effect of propranolol in modelling of chronic ischemic heart disease]. ( Danilishina, MV; Gavrish, AS; Shchul'ts, NV; Verbitskiĭ, VV, 2002) |
| "Hemorrhage was induced in fasted anesthetized rats, and the reduction of blood pressure to 40 mm Hg for a duration of 30 minutes was accomplished by withdrawal or infusion of shed blood." | 1.31 | Regulation of liver and kidney glucose-6-phosphatase gene expression in hemorrhage and resuscitation. ( El-Maghrabi, MR; Henry, MC; Maitra, SR; Wang, S, 2000) |
| "Cardiac hypertrophy was induced in rats by chronic s." | 1.31 | Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation. ( Bokník, P; Fockenbrock, M; Herzig, S; Knapp, J; Linck, B; Lüss, H; Müller, FU; Müller, T; Neumann, J; Schmitz, W; Schröder, F, 2000) |
| "Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent." | 1.31 | Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001) |
| "Ventricular arrhythmias and contractile dysfunction are the main causes of death in human heart failure (HF)." | 1.31 | Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. ( Bers, DM; Li, L; Pogwizd, SM; Schlotthauer, K; Yuan, W, 2001) |
| " This simple and sensitive assay method was feasibly applied to the pharmacokinetic study of propranolol after intravenous administration of 2 mg/kg of propranolol to normal and carbon tetrachloride-induced liver cirrhotic rats." | 1.31 | Determination of propranolol concentration in small volume of rat plasma by HPLC with fluorometric detection. ( Hong, JH; Kang, JS; Kim, HK; Lee, MH; Park, MS, 2001) |
| " Thirty minutes after the development of toxicity, toxic measures were taken (treatment 0 minutes), and then the animals (n = 6 each group) received either sham (saline solution), insulin (4 IU/minute with glucose clamped), glucagon (50 micrograms/kg bolus, then 150 micrograms/kg/hour infusion), or epinephrine (1 microgram/kg/minute)." | 1.30 | Insulin improves survival in a canine model of acute beta-blocker toxicity. ( Kerns, W; Raymond, R; Schroeder, D; Tomaszewski, C; Williams, C, 1997) |
| "Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats." | 1.30 | Hemodynamic effects of chronic tetrandrine and propranolol administration on portal hypertensive rats. ( Hong, CY; Huang, YT; Lin, HC; Liu, TB; Yang, MC, 1997) |
| "Propofol did not produce direct effects on the electrophysiological or electrocardiographical variables at any infusion rates." | 1.30 | Propofol does not affect the canine cardiac conduction system under autonomic blockade. ( Akazawa, S; Ikeno, S; Inoue, S; Ishii, R; Nakaigawa, Y; Satoh, M; Shimizu, R, 1999) |
| "Portal hypertension was induced by partial portal vein ligation (PVL)." | 1.30 | Increased angiogenesis in portal hypertensive rats: role of nitric oxide. ( Battegay, E; Sieber, CC; Stumm, M; Sumanovski, LT; van der Kooij, M, 1999) |
| "Propranolol was inhaled 20 minutes after an antigen challenge in passively sensitized, anesthetized, and artificially ventilated guinea pigs." | 1.30 | Difference in bronchoprotective effects of bronchodilators on postallergic propranolol-induced bronchoconstriction. ( Fujimura, M; Ishiura, Y; Matsuda, T; Mizuhashi, K; Myou, S, 1999) |
| "Nicotine caused an increase in respiratory rate and this effect was abolished by prazosin." | 1.29 | Effects of adrenoceptor blockers on the cardiorespiratory response to nicotine in rats. ( Fasanmade, AA; Oyebola, DD, 1993) |
| " Dose-response curves with epinephrine from lean mice were best fit to a two-component model comprised of 23% high affinity (K(act) = 1." | 1.29 | Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. ( Collins, S; Daniel, KW; Gettys, TW; Ramkumar, V; Rohlfs, EM; Taylor, IL, 1994) |
| "The chronic renal failure was induced by surgical ablation of 75% renal mass." | 1.28 | [Effects of alpha and beta receptor blockaders on urinary excretion of sodium and potassium in healthy rats and in those with chronic renal failure]. ( Jakubowski, Z; Manitius, A; Manitius, J, 1992) |
| "A second spell of arrhythmia of similar intensity and pattern, which had the same latency to onset, was reproduced 60 min after the first spell of arrhythmia." | 1.28 | Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model. ( Thomas, GP; Varma, RK, 1991) |
| "DESIGN - Endotoxin shock was obtained in dogs by giving S Typhimurium endotoxin intravenously (1 mg." | 1.28 | Insulin and beta adrenergic effects during endotoxin shock: in vivo myocardial interactions. ( Law, WR; McLane, MP; Raymond, RM, 1990) |
| "Dopexamine hydrochloride is a new analog of dopamine that lowers systemic vascular resistance and has positive inotropic and chronotropic properties, but lacks the alpha-adrenoceptor agonist activity of dopamine." | 1.28 | Effects of dopexamine hydrochloride on hypoxic pulmonary vasoconstriction in isolated rat lung. ( Barnes, PJ; Evans, TW; McCormack, DG, 1990) |
| "Rats with chronic portal hypertension have an increased gastric mucosal blood flow and an impaired acid secretory response to pentagastrin stimulation." | 1.28 | Effects of propranolol on gastric microcirculation and acid secretion in portal hypertensive rats. ( Bosch, J; Pérez Ayuso, RM; Piqué, JM; Pizcueta, P, 1990) |
| "Hypertension was induced by a methoxamine HCl iv infusion which mimicked the cardiac effects seen in essential hypertension." | 1.28 | Effect of propranolol on the myocardial contractility of normotensive and spontaneously hypertensive rabbits: relationship of pharmacokinetics and pharmacodynamics. ( Chien, YW; Corbo, M; Li, JK; Wang, PR, 1989) |
| "Young turkeys inbred for congestive cardiomyopathy (CCM) were treated with propranolol prior to the development of cardiac enlargement." | 1.27 | Effect of early propranolol treatment in an animal model of congestive cardiomyopathy. II. beta-adrenergic receptors and left ventricular function. ( Einzig, S; Noren, GR; Rublein, TG; Staley, NA, 1984) |
| "Propranolol treated inbred birds showed a significantly reduced mortality from 5 to 15 days of age when compared with untreated inbred birds." | 1.27 | Effect of early propranolol treatment in an animal model of congestive cardiomyopathy: I Mortality and Ca2+ transport in sarcoplasmic reticulum. ( Einzig, S; Noren, GR; Rublein, TG; Staley, NA, 1984) |
| "Oxprenolol and carteolol were observed to have mild effects on the abnormal ECG as compared with propranolol." | 1.27 | [The abnormal ECG and the appearance of methacholine-induced arrhythmias in SART mice and effects of beta-blockers, oxprenolol, propranolol, and carteolol]. ( Harada, N; Hata, T; Itoh, E; Kita, T, 1984) |
| " Toxic levels of theophylline were associated with hypokalemia, hypophosphatemia, hyperglycemia, metabolic acidosis, and hypotension in both the patient and the experimental series." | 1.27 | Theophylline toxicity and the beta-adrenergic system. ( Curtis, GP; Kearney, TE; Manoguerra, AS; Ziegler, MG, 1985) |
| "[3H]Yohimbine binding sites were not significantly altered." | 1.27 | Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma. ( Hashimoto, K; Hoffman, BB; Honda, K; Tsujimoto, G, 1987) |
| "Protection from arrhythmias seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation." | 1.27 | The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. ( Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G, 1985) |
| " When keeping the heart rate constant by means of a pace maker, carbocromen even at higher dosage caused a clear-cut improvement." | 1.26 | [The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)]. ( Kunath, B; Nitz, RE; Scholtholt, J; Sirbulescu, R, 1976) |
| "In this model of acute renal failure, renal vasoconstriction plays an important role following the initial ischemic insult." | 1.26 | Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure. ( D'Agostini, RJ; Freedman, MT; Heptinstall, RH; Scott, WW; Siegelman, SS; Solez, K; Stawowy, L, 1977) |
| "Pretreatment with propranolol reduced necrosis from 85 +/- 3% (untreated) to 52 +/- 4% (P less than 0." | 1.26 | Infarct size reduction by propranolol before and after coronary ligation in dogs. ( Jennings, RB; Kloner, RA; Rasmussen, MM; Reimer, KA, 1977) |
| "Myocardial infarction was produced by occlusion of the left circumflex coronary artery for 60 minutes followed by reperfusion and quantitation of infarct volume 24 hours later." | 1.26 | Ischemic changes in the canine heart as affected by the dimethyl quaternary analog of propranolol, UM-272 (SC-27761). ( Abrams, GD; Burmeister, WE; Lomas, TE; Lucchesi, BR, 1976) |
| "Propranolol has been shown to reduce the extent of necrosis that develops after temporary coronary occlusion in dogs." | 1.26 | On the nature of protection by propranolol against myocardial necrosis after temporary coronary occlusion in dogs. ( Jennings, RB; Rasmussen, MM; Reimer, KA, 1976) |
| "Propranolol has been shown to improve bioenergetics and reduce anaerobic glycolysis by a depression of the hemodynamic response of ischemic myocardium." | 1.26 | Metabolic evaluation of agents designed to protect the ischemic myocardium and to reduce infarct size. ( Brachfeld, N, 1976) |
| "When controlled hypotension is added to myocardial depression, aortic dissection is inhibited completely." | 1.25 | Control of acute aortic dissection. ( Carney, WI; Cleveland, RJ; Rheinlander, HF, 1975) |
| "Of particular importance are the arrhythmias observed immediately after experimentally induced acute myocardial infarction (AMI)." | 1.25 | Pharmacological modification of arrhythmias after experimentally induced acute myocardial infarction. Drugs acting on the nervous system. ( Kniffen, FJ; Lucchesi, BR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 131 (28.42) | 18.7374 |
| 1990's | 64 (13.88) | 18.2507 |
| 2000's | 80 (17.35) | 29.6817 |
| 2010's | 158 (34.27) | 24.3611 |
| 2020's | 28 (6.07) | 2.80 |
| Authors | Studies |
|---|---|
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Li, P | 2 |
| Robertson, TA | 2 |
| Thorling, CA | 1 |
| Zhang, Q | 2 |
| Fletcher, LM | 2 |
| Crawford, DH | 2 |
| Roberts, MS | 2 |
| Więckowska, A | 1 |
| Więckowski, K | 1 |
| Bajda, M | 1 |
| Brus, B | 1 |
| Sałat, K | 1 |
| Czerwińska, P | 1 |
| Gobec, S | 1 |
| Filipek, B | 1 |
| Malawska, B | 1 |
| Papadopoulou, MV | 1 |
| Bloomer, WD | 1 |
| Rosenzweig, HS | 1 |
| O'Shea, IP | 1 |
| Wilkinson, SR | 1 |
| Kaiser, M | 1 |
| Chatelain, E | 2 |
| Ioset, JR | 1 |
| Thompson, AM | 1 |
| Marshall, AJ | 1 |
| Maes, L | 1 |
| Yarlett, N | 1 |
| Bacchi, CJ | 1 |
| Gaukel, E | 1 |
| Wring, SA | 1 |
| Launay, D | 1 |
| Braillard, S | 1 |
| Mowbray, CE | 1 |
| Denny, WA | 1 |
| Nocentini, A | 1 |
| Ceruso, M | 1 |
| Bua, S | 1 |
| Lomelino, CL | 1 |
| Andring, JT | 1 |
| McKenna, R | 1 |
| Lanzi, C | 1 |
| Sgambellone, S | 1 |
| Pecori, R | 1 |
| Matucci, R | 1 |
| Filippi, L | 3 |
| Gratteri, P | 1 |
| Carta, F | 1 |
| Masini, E | 1 |
| Selleri, S | 1 |
| Supuran, CT | 1 |
| Shouksmith, AE | 1 |
| Shah, F | 1 |
| Grimard, ML | 1 |
| Gawel, JM | 1 |
| Raouf, YS | 1 |
| Geletu, M | 1 |
| Berger-Becvar, A | 1 |
| de Araujo, ED | 1 |
| Luchman, HA | 1 |
| Heaton, WL | 1 |
| Bakhshinyan, D | 1 |
| Adile, AA | 1 |
| Venugopal, C | 1 |
| O'Hare, T | 1 |
| Deininger, MW | 1 |
| Singh, SK | 1 |
| Konieczny, SF | 1 |
| Weiss, S | 1 |
| Fishel, ML | 1 |
| Gunning, PT | 1 |
| Wu, Y | 1 |
| Zhou, Q | 1 |
| Zhang, T | 1 |
| Li, Z | 2 |
| Chen, YP | 1 |
| Zhang, P | 1 |
| Yu, YF | 1 |
| Geng, H | 1 |
| Tian, YJ | 1 |
| Zhang, C | 2 |
| Wang, Y | 5 |
| Chen, JW | 1 |
| Chen, Y | 3 |
| Luo, HB | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Czopek, A | 1 |
| Bucki, A | 1 |
| Kołaczkowski, M | 1 |
| Zagórska, A | 1 |
| Drop, M | 1 |
| Pawłowski, M | 1 |
| Siwek, A | 1 |
| Głuch-Lutwin, M | 1 |
| Pękala, E | 1 |
| Chrzanowska, A | 1 |
| Struga, M | 1 |
| Partyka, A | 1 |
| Wesołowska, A | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 2 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Michalovicz, LT | 1 |
| Kelly, KA | 1 |
| Miller, DB | 1 |
| Sullivan, K | 1 |
| O'Callaghan, JP | 1 |
| Kodama, T | 1 |
| Kameshima, S | 1 |
| Otani, K | 2 |
| Okada, M | 1 |
| Yamawaki, H | 1 |
| Lopez, AJ | 2 |
| ElSaadani, M | 2 |
| Jacovides, CL | 2 |
| Georges, A | 1 |
| Culkin, MC | 2 |
| Ahmed, S | 1 |
| Kumar, MA | 2 |
| Kaplan, LJ | 2 |
| Smith, DH | 2 |
| Pascual, JL | 2 |
| Su, S | 1 |
| Zou, P | 1 |
| Yang, G | 2 |
| Liu, L | 1 |
| Liu, Y | 4 |
| Zhang, J | 2 |
| Ding, Y | 1 |
| Georges, AP | 1 |
| Song, H | 1 |
| Uccello, TP | 1 |
| Lesch, ML | 1 |
| Ullman, NA | 1 |
| Kintzel, SA | 1 |
| Gradzewicz, LB | 1 |
| Velagaleti, T | 1 |
| Fleming, FJ | 1 |
| Mills, BN | 1 |
| Murphy, JD | 1 |
| Garrett-Larsen, J | 1 |
| Qiu, H | 1 |
| Drage, MG | 1 |
| Ye, J | 1 |
| Gavras, NW | 1 |
| Johnston, CJ | 1 |
| Love, TMT | 1 |
| Repasky, EA | 1 |
| Linehan, DC | 1 |
| Lord, EM | 1 |
| Gerber, SA | 1 |
| Singer, KE | 2 |
| McGlone, ED | 1 |
| Collins, SM | 1 |
| Wallen, TE | 3 |
| Morris, MC | 2 |
| Schuster, RM | 2 |
| England, LG | 2 |
| Robson, MJ | 1 |
| Goodman, MD | 3 |
| Baucom, MR | 1 |
| Pritts, TA | 1 |
| Zeeshan, M | 1 |
| Hamidi, M | 1 |
| OʼKeeffe, T | 1 |
| Bae, EH | 1 |
| Hanna, K | 1 |
| Friese, RS | 1 |
| Kulvatunyou, N | 1 |
| Zakaria, ER | 1 |
| Gries, L | 1 |
| Tang, A | 1 |
| Joseph, B | 1 |
| Armstead, WM | 1 |
| Vavilala, MS | 1 |
| Seara, FAC | 1 |
| Araujo, IG | 1 |
| Império, GE | 1 |
| Marassi, MP | 1 |
| Silva, ACM | 1 |
| Mecawi, AS | 1 |
| Reis, LC | 1 |
| Olivares, EL | 1 |
| Omri, S | 1 |
| Tahiri, H | 1 |
| Pierre, WC | 1 |
| Desjarlais, M | 1 |
| Lahaie, I | 1 |
| Loiselle, SE | 1 |
| Rezende, F | 1 |
| Lodygensky, G | 1 |
| Hebert, TE | 1 |
| Ong, H | 1 |
| Chemtob, S | 1 |
| Droho, S | 1 |
| Cuda, CM | 1 |
| Perlman, H | 1 |
| Lavine, JA | 3 |
| Ciprés-Flores, FJ | 1 |
| Farfán-García, ED | 1 |
| Andrade-Jorge, E | 1 |
| Cuevas-Hernández, RI | 1 |
| Tamay-Cach, F | 1 |
| Martínez-Archundia, M | 1 |
| Trujillo-Ferrara, JG | 1 |
| Soriano-Ursúa, MA | 1 |
| Cole, JB | 2 |
| Corcoran, JN | 1 |
| Engebretsen, KM | 4 |
| Stellpflug, SJ | 3 |
| Tsai, HC | 1 |
| Hsu, CF | 1 |
| Huang, CC | 1 |
| Huang, SF | 1 |
| Li, TH | 1 |
| Yang, YY | 2 |
| Lin, MW | 1 |
| Lee, TY | 2 |
| Liu, CW | 1 |
| Huang, YH | 1 |
| Hou, MC | 1 |
| Lin, HC | 4 |
| Stüssel, P | 1 |
| Schulze Dieckhoff, K | 1 |
| Künzel, S | 1 |
| Hartmann, V | 1 |
| Gupta, Y | 1 |
| Kaiser, G | 1 |
| Veldkamp, W | 1 |
| Vidarsson, G | 1 |
| Visser, R | 1 |
| Ghorbanalipoor, S | 1 |
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| Illner, H | 1 |
| Shires, GT | 1 |
| Ishiura, Y | 2 |
| Faffe, DS | 1 |
| Chagas, PS | 1 |
| Medeiros, AS | 1 |
| Saad, EA | 1 |
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| Morgan, JP | 1 |
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| Suetsugu, M | 1 |
| Hisamatsu, Y | 1 |
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| Scherlag, BJ | 1 |
| Yamanashi, WS | 1 |
| Schauerte, P | 1 |
| Scherlag, M | 1 |
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| Jackman, WM | 1 |
| Lazzara, R | 1 |
| Shatney, CH | 1 |
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| Iaina, A | 3 |
| Solomon, S | 3 |
| Eliahou, H | 1 |
| Vareilles, P | 1 |
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| Le Douarec, JC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds: A Randomized Controlled Trial[NCT03452072] | Phase 2/Phase 3 | 88 participants (Actual) | Interventional | 2018-08-20 | Completed | ||
| Safety and Efficacy of Propranolol Eye Drops in Newborns With Retinopathy of Premature (DROP-PROP)[NCT02014454] | Phase 2 | 23 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Safety and Efficacy of Propranolol 0.2% Eye Drops in Treating Newborn With Retinopathy of Premature: A Pilot Study (DROP-ROP-0.2%)[NCT02504944] | Phase 2 | 98 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Safety and Efficacy of Propranolol Treatment in Newborns With Retinopathy of Prematurity:a Prospective Cohort Study[NCT03038295] | Phase 2 | 100 participants (Anticipated) | Interventional | 2017-03-31 | Not yet recruiting | ||
| Improving Perioperative Pain Management for Laparoscopic Surgery Due to Colon Cancer Using the Ultrasound-guided Transmuscular Quadratus Lumborum Block. A Double Blind, Randomized, Placebo Controlled Trial.[NCT03570541] | Phase 4 | 69 participants (Actual) | Interventional | 2018-06-28 | Completed | ||
| Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery[NCT03974984] | 0 participants (Actual) | Observational | 2020-06-04 | Withdrawn (stopped due to Not feasable due to logistics) | |||
| Impact of Novel Thoracic Wall Blocks With Dexmetomidine on Inflammatory Markers Following Breast Cancer Surgery[NCT04860115] | 120 participants (Anticipated) | Interventional | 2021-11-01 | Not yet recruiting | |||
| Impact of Early CRRT Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality: A Randomized Controlled Trial[NCT03549923] | Phase 4 | 550 participants (Anticipated) | Interventional | 2018-12-18 | Recruiting | ||
| Role of Th1-lymphocytes in the Development of Vascular Cognitive Impairment in Young Stroke Patients[NCT03725137] | 77 participants (Anticipated) | Observational | 2020-01-31 | Not yet recruiting | |||
| Predictors of Early Chest Infection in Acute Ischemic Stroke[NCT00906542] | 530 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Effects of Losartan vs. Nebivolol vs. the Association of Both on the Progression of Aortic Root Dilation in Marfan Syndrome (MFS) With FBN1 Gene Mutations.[NCT00683124] | Phase 3 | 291 participants (Anticipated) | Interventional | 2008-07-31 | Recruiting | ||
| Electromechanical Profiling of Arrhythmogenic Substrates and Triggers in the Long-QT Syndrome[NCT04074122] | 150 participants (Anticipated) | Observational | 2020-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for propranolol and Disease Models, Animal
| Article | Year |
|---|---|
Update on Clinical Trials of Losartan With and Without β-Blockers to Block Aneurysm Growth in Patients With Marfan Syndrome: A Review.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Aneurysm, Thor | 2019 |
[Prophylaxis and therapy of post-traumatic stress disorder with propranolol: evidence and ethical analysis].
Topics: Adrenergic beta-Antagonists; Animals; Arousal; Combined Modality Therapy; Disease Models, Animal; Et | 2013 |
[My research on asthma today and in the future].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; D | 2013 |
Revisiting propranolol and PTSD: Memory erasure or extinction enhancement?
Topics: Adrenergic beta-Antagonists; Animals; Behavior, Animal; Disease Models, Animal; Extinction, Psycholo | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Adrenergic, Inflammatory, and Immune Function in the Setting of Oncological Surgery: Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Disease Models, Animal; Disease Progr | 2016 |
Beta-block the septic heart.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Disease Models, Animal; Heart; Humans; Pro | 2010 |
A novel chemically induced animal model of human anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Blood Pressure; Carbolines; Cloni | 1984 |
Myocardial perfusion dependent and independent mechanisms of regional myocardial dysfunction in hypertrophy.
Topics: Animals; Cardiomegaly; Coronary Circulation; Disease Models, Animal; Dogs; Heart; Hemodynamics; Myoc | 1993 |
Cocaine and beta-adrenergic blockers: a remarriage after a decade-long divorce?
Topics: Adrenergic beta-Antagonists; Animals; Cardiovascular Diseases; Cerebrovascular Disorders; Cocaine-Re | 1999 |
beta-Adrenoceptor blocking drugs and hypertension.
Topics: Adrenal Medulla; Adrenergic beta-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Blood Pr | 1979 |
Tissue salvage in acute myocardial infarction.
Topics: Animals; Assisted Circulation; Collateral Circulation; Coronary Circulation; Coronary Disease; Creat | 1979 |
The effects of hypoxaemia in fetal sheep.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Epine | 1977 |
The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blood Volume; Disease Models, Animal; Diuresis | 1975 |
Myocardial ischemia (third of three parts).
Topics: Acute Disease; Animals; Assisted Circulation; Coronary Disease; Disease Models, Animal; Dogs; Glucoc | 1977 |
New concepts of the renin system and of vasoconstriction-volume mechanisms. Diagnosis and treatment of renovascular and renal hypertensions.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Disease Models, Animal; Humans; Hyper | 1975 |
An endocrine experimental model for myofibrillar disarray as found in hypertrophic cardiomyopathy.
Topics: Adrenergic beta-Antagonists; Animals; Calcium; Calcium Channel Blockers; Cardiomyopathy, Hypertrophi | 1985 |
Central nervous system mechanisms in blood pressure control.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Cloni | 1985 |
Importance of receptor regulation in the pathophysiology and therapy of congestive heart failure.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Dogs; | 1986 |
443 other studies available for propranolol and Disease Models, Animal
| Article | Year |
|---|---|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cations; Cytochrome P-450 | 2011 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrie | 2015 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice | 2015 |
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mic | 2018 |
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
Topics: Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystall | 2018 |
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.
Topics: Animals; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease | 2019 |
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Binding Sites; Catalytic Domain; | 2019 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Receptors, Serotonin; St | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Corticosterone | 2021 |
Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic effect via renal vasorelaxation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Diuretics; Elongation Factor 2 Kinase; Humans; Hype | 2021 |
Beta blockade in TBI: Dose-dependent reductions in BBB leukocyte mobilization and permeability in vivo.
Topics: Animals; Blood-Brain Barrier; Body Weight; Brain Edema; Brain Injuries, Traumatic; Chronic Traumatic | 2022 |
Propranolol ameliorates retinopathy of prematurity in mice by downregulating HIF-1α via the PI3K/Akt/ERK pathway.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Humans; Infant, Newborn; MAP Kinase Signaling Sy | 2023 |
Persistent Blunting of Penumbral Leukocyte Mobilization by Beta Blockade Administered for Two Weeks After Traumatic Brain Injury.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Leukoc | 2022 |
Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer.
Topics: Animals; Disease Models, Animal; Humans; Isoproterenol; Mice; Mice, Inbred C57BL; Propranolol; Recta | 2023 |
Propranolol Reduces p-tau Accumulation and Improves Behavior Outcomes in a Polytrauma Murine Model.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Male; Mice; Multiple Trauma; Pro | 2023 |
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th | 2022 |
Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Brain Injuries, Traumatic; CA1 Region, Hippocampal; | 2019 |
Propranolol protects cerebral autoregulation and reduces hippocampal neuronal cell death through inhibition of interleukin-6 upregulation after traumatic brain injury in pigs.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Brain Injuries, Traumatic; Cell Death; Disea | 2019 |
Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
Topics: Adipose Tissue, Brown; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Iodide Peroxida | 2019 |
Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization.
Topics: Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Animals; Blotting, Western; Caspase 3; Cell Li | 2019 |
Monocyte-Derived Macrophages Are Necessary for Beta-Adrenergic Receptor-Driven Choroidal Neovascularization Inhibition.
Topics: Adrenergic beta-Antagonists; Animals; Choroid; Choroidal Neovascularization; Disease Models, Animal; | 2019 |
Identification of two arylimides as cholinesterase inhibitors and testing of propranolol addition on impaired rat memory.
Topics: Amides; Animals; Cholinesterase Inhibitors; Computer Simulation; Disease Models, Animal; Drug Therap | 2020 |
Use of a Porcine Model to Evaluate the Risks and Benefits of Vasopressors in Propranolol Poisoning.
Topics: Adrenergic beta-Antagonists; Animals; Cardiotoxicity; Disease Models, Animal; Drug Administration Sc | 2020 |
Propranolol Suppresses the T-Helper Cell Depletion-Related Immune Dysfunction in Cirrhotic Mice.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Humans; Liver Cirrhosis; Male; Mice; P | 2020 |
Propranolol Is an Effective Topical and Systemic Treatment Option for Experimental Epidermolysis Bullosa Acquisita.
Topics: Administration, Cutaneous; Administration, Oral; Adrenergic beta-Antagonists; Animals; Cells, Cultur | 2020 |
Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke.
Topics: Adrenergic beta-Antagonists; Animals; Brain Injuries; Cell Line; Cytokines; Disease Models, Animal; | 2020 |
Blockade of muscarinic receptors impairs reconsolidation of older fear memory by decreasing cholinergic neurotransmission: A study in rat model of PTSD.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Conditioning, Classical; Disease Models, Animal; Fea | 2020 |
A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; | 2021 |
The role of vimentin, Connexin-43 proteins, and oxidative stress in the protective effect of propranolol against clozapine-induced myocarditis and apoptosis in rats.
Topics: Adrenergic beta-Antagonists; Animals; Antipsychotic Agents; Apoptosis; Cardiotonic Agents; Caspase 3 | 2021 |
Role of β
Topics: Acetanilides; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic b | 2020 |
Can propranolol act as a chemopreventive agent during oral carcinogenesis? An experimental animal study.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Mo | 2021 |
The α1-adrenergic receptors in the amygdala regulate the induction of learned despair through protein kinase C-beta signaling.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Amygdala; Animals; Depressive | 2021 |
Curcuma's extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin, proliferating cell nuclear antigen and toll-like receptor expression.
Topics: Animals; Curcuma; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Epi | 2020 |
Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model.
Topics: Animals; Biomarkers; Brain; Catechin; Disease Models, Animal; Gliosis; Glucans; Hippocampus; Inclusi | 2021 |
Propranolol Reduces the Development of Lesions and Rescues Barrier Function in Cerebral Cavernous Malformations: A Preclinical Study.
Topics: Animals; Central Nervous System Neoplasms; Disease Models, Animal; Female; Hemangioma, Cavernous, Ce | 2021 |
Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes.
Topics: Action Potentials; Animals; Atrioventricular Block; Atrioventricular Node; Atropine; Biopsy; Calcium | 2021 |
Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
Topics: Adenosine; Air Ambulances; Allopurinol; Amitriptyline; Animals; Brain; Brain Chemistry; Brain Injuri | 2021 |
Intracerebroventricular injection of propranolol blocked analgesic and neuroprotective effects of resveratrol following L
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Ligation; Male; Neuroprotective Agents; P | 2021 |
Preoperative and perioperative intervention reduces the risk of recurrence of endometriosis in mice caused by either incomplete excision or spillage and dissemination.
Topics: Animals; Aprepitant; Cell Proliferation; Combined Modality Therapy; Disease Models, Animal; Diterpen | 2021 |
Mechanical mandible competence in rats with nutritional growth retardation.
Topics: Adrenergic beta-Antagonists; Animals; Biomarkers; Biomechanical Phenomena; Body Weight; Bone Disease | 2017 |
Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice.
Topics: 3-Hydroxybutyric Acid; Adrenergic beta-Antagonists; Animals; Brain; Brain Ischemia; Citric Acid; Die | 2017 |
Paeoniflorin suppressed IL-22 via p38 MAPK pathway and exerts anti-psoriatic effect.
Topics: Animals; Blotting, Western; Cell Line; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ge | 2017 |
Effects of Propranolol and Verapamil on Changes in TQ and ST Segment Potentials During Graded Coronary Flow Reduction in a Porcine Myocardial Ischemia Model.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Disease Models, Animal; Electrocardi | 2017 |
Topical 1% propranolol cream promotes cutaneous wound healing in spontaneously diabetic mice.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Antigens; Blotting, Western; Diabetes | 2017 |
Propranolol Effects on Decompression Sickness in a Simulated DISSUB Rescue in Swine.
Topics: Adrenergic beta-Antagonists; Animals; Decompression Sickness; Disease Models, Animal; Diving; Heart | 2017 |
Discrete β-adrenergic mechanisms regulate early and late erythropoiesis in erythropoietin-resistant anemia.
Topics: Adrenergic Antagonists; Anemia; Animals; Burns; Butoxamine; Disease Models, Animal; Erythropoiesis; | 2017 |
Noradrenergic antagonists mitigate amphetamine-induced recovery.
Topics: Adrenergic Antagonists; Amphetamine; Animals; Central Nervous System Stimulants; Cerebral Cortex; Di | 2017 |
Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation.
Topics: Animals; Benzyl Alcohols; Disease Models, Animal; Dura Mater; Glucosides; Levetiracetam; Male; Medic | 2018 |
Role of ghrelin in small intestinal motility following pediatric intracerebral hemorrhage in mice.
Topics: Animals; Atropine; Cerebral Hemorrhage; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immun | 2017 |
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Blood-Brain Barrier; Bra | 2018 |
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Topics: Adrenergic beta-Antagonists; Allosteric Regulation; Animals; Anticonvulsants; Calcitonin Gene-Relate | 2018 |
TRPML1 Participates in the Progression of Alzheimer's Disease by Regulating the PPARγ/AMPK/Mtor Signalling Pathway.
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Amyloid beta-Protein Precur | 2017 |
Anti-Psoriasis Effects and Mechanisms of Α-(8-Quinolinoxy) Zinc Phthalocyanine-Mediated Photodynamic Therapy.
Topics: Aminoquinolines; Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Epidermis; Epitheli | 2017 |
ClC-3 chloride channel is involved in isoprenaline-induced cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Cardiomegaly; Cell Line; Chloride Channels; Dependovirus; Disease Models, | 2018 |
Significant inhibition of infantile hemangioma growth by sustained delivery of urea from liposomes-in-microspheres.
Topics: Administration, Oral; Animals; Cell Proliferation; Cells, Cultured; Delayed-Action Preparations; Dis | 2018 |
Astilbin emulsion improves guinea pig lesions in a psoriasis-like model by suppressing IL-6 and IL-22 via p38 MAPK.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Transformed; Disease Models, Animal; Ear; Emulsions; F | 2018 |
Influence of early stress on memory reconsolidation: Implications for post-traumatic stress disorder treatment.
Topics: Adrenergic beta-Antagonists; Animals; Conditioning, Classical; Corticosterone; Disease Models, Anima | 2018 |
Propranolol can induce PTSD-like memory impairments in rats.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fear | 2018 |
Propranolol produces short-term facilitation of extinction in a rabbit model of post-traumatic stress disorder.
Topics: Adrenergic beta-Antagonists; Animals; Arousal; Blinking; Conditioning, Classical; Conditioning, Eyel | 2018 |
β-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke.
Topics: Animals; beta-Arrestin 2; Brain Infarction; Cell Line, Transformed; Cytokines; Disease Models, Anima | 2018 |
The role of propranolol as a radiosensitizer in gastric cancer treatment.
Topics: Animals; Disease Models, Animal; Humans; Male; Mice, Nude; Neoplasms, Experimental; Propranolol; Rad | 2018 |
Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression.
Topics: Animals; Autophagy; Carbohydrate Metabolism; Cell Line, Tumor; Disease Models, Animal; Disease Progr | 2018 |
β-blockers interfere with cell homing receptors and regulatory proteins in a model of spontaneously hypertensive rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agent | 2018 |
Anti-tumor effects of propranolol: Adjuvant activity on a transplanted murine breast cancer model.
Topics: Adjuvants, Immunologic; Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Breast Neoplasms; C | 2018 |
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbama | 2018 |
Early propranolol treatment ameliorates endothelial dysfunction in experimental septic lung.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Ligation; Lung; Male; Propranolol; Rats; Rats, W | 2019 |
Effects of epinephrine on heart rate variability and cytokines in a rat sepsis model.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-1 Receptor Antagonists; Animals; Cytokines; Disease Model | 2020 |
In vitro analysis of drugs that improve hyperglycemia-induced blood-brain barrier dysfunction.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Cilostazol; Disease Models, Animal | 2018 |
Propranolol increases vascular permeability through pericyte apoptosis and exacerbates oxygen-induced retinopathy.
Topics: Animals; Animals, Newborn; Apoptosis; Capillary Permeability; Coculture Techniques; Disease Models, | 2018 |
Arrhythmias precede cardiomyopathy and remodeling of Ca
Topics: Action Potentials; Animals; Calcium; Cardiomyopathies; Disease Models, Animal; Disease Progression; | 2018 |
Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder.
Topics: Adrenergic Agents; Animals; Anxiety; Cardiovascular Agents; Clonidine; Disease Models, Animal; Disea | 2019 |
Propranolol inhibits the activity of PI3K, AKT, and HIF-1α in infantile hemangiomas.
Topics: Animals; Disease Models, Animal; Hemangioma; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, Nude; | 2018 |
Voluntary exercise or systemic propranolol ameliorates stress-related maladaptive behaviors in female rats.
Topics: Adrenergic beta-Antagonists; Animals; Behavior, Animal; Disease Models, Animal; Female; Motor Activi | 2019 |
Combined Antihypertensive Therapies That Increase Expression of Cardioprotective Biomarkers Associated With the Renin-Angiotensin and Kallikrein-Kinin Systems.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme | 2018 |
Propranolol prevents cerebral blood flow changes and pain-related behaviors in migraine model mice.
Topics: Adrenergic beta-Antagonists; Animals; Cerebrovascular Circulation; Cortical Spreading Depression; Di | 2019 |
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis.
Topics: Adrenergic beta-Antagonists; Adrenergic Fibers; Animals; Bone and Bones; Bone Density; Bone Regenera | 2019 |
A randomized controlled study comparing high-dose insulin to vasopressors or combination therapy in a porcine model of refractory propranolol-induced cardiogenic shock.
Topics: Adrenergic beta-Antagonists; Animals; Arterial Pressure; Disease Models, Animal; Drug Therapy, Combi | 2019 |
Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Atrial Natriuretic Factor; Cardiomegaly; Disease M | 2019 |
Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome.
Topics: Adrenergic beta-Antagonists; Animals; Aorta; Aortic Dissection; Disease Models, Animal; Female; Hydr | 2019 |
R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Enzyme Inhibitors; Hemangioma; Humans; | 2019 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
Eye drop propranolol administration promotes the recovery of oxygen-induced retinopathy in mice.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Infa | 2013 |
A blinded, randomized, controlled trial of three doses of high-dose insulin in poison-induced cardiogenic shock.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Inbred Strains; Arterial Pressure; Blood Glucose; Car | 2013 |
Protective effects of ranolazine and propranolol, alone or combined, on the structural and functional alterations of cardiomyocyte mitochondria in a pig model of ischemia/reperfusion.
Topics: Acetanilides; Animals; Calcium; Cardiotonic Agents; Disease Models, Animal; Drug Therapy, Combinatio | 2014 |
Involvement of transmitters in the anxiolytic action of urocortin 3 in mice.
Topics: Analysis of Variance; Animals; Anxiety; Atropine; Bicuculline; Disease Models, Animal; Dose-Response | 2013 |
Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; | 2013 |
Gβγ-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor α-induced cardiac β-adrenergic receptor dysfunction.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 2; H | 2013 |
Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Tran | 2013 |
Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis.
Topics: Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Apoptosis; Choline; Culture Media; Disea | 2013 |
Effects of peritoneal dialysis on pharmacotherapy: a deductive pharmacokinetic-model approach to predict drug concentration profiles in plasma and peritoneal fluid.
Topics: Acute Kidney Injury; Animals; Ascitic Fluid; Cefazolin; Disease Models, Animal; Male; Models, Biolog | 2014 |
Propranolol prevents life-threatening arrhythmias in LQT3 transgenic mice: implications for the clinical management of LQT3 patients.
Topics: Adrenergic beta-Antagonists; Animals; Cardiac Conduction System Disease; Death, Sudden, Cardiac; Dis | 2014 |
Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats.
Topics: Adipose Tissue; Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocyt | 2014 |
Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Echo | 2014 |
The effect of β receptor blockade through propranolol on corneal neovascularization.
Topics: Adrenergic beta-Antagonists; Animals; Burns, Chemical; Caspase 3; Caustics; Corneal Neovascularizati | 2014 |
mRNA of cytokines in bone marrow and bone biomarkers in response to propranolol in a nutritional growth retardation model.
Topics: Animals; Biomarkers; Bone Marrow; Bone Remodeling; Disease Models, Animal; Femur; Food Deprivation; | 2014 |
Comparative portal hypotensive effects as propranolol of vitamin D₃ treatment by decreasing intrahepatic resistance in cirrhotic rats.
Topics: Adrenergic beta-Antagonists; Animals; Cholecalciferol; Disease Models, Animal; Drug Therapy, Combina | 2015 |
Effects of repeated propranolol administration in a rat model of surgically induced endometriosis.
Topics: Abdominal Wall; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Endometriosis; Endomet | 2014 |
The effect of fat emulsion on hemodynamics following treatment with propranolol and clonidine in anesthetized rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Clonidine; D | 2014 |
Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats.
Topics: Acetic Acid; Adrenergic beta-Antagonists; Animals; Cats; Disease Models, Animal; Electric Stimulatio | 2015 |
The effect of Midazolam and Propranolol on fear memory reconsolidation in ethanol-withdrawn rats: influence of d-cycloserine.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Conditioning, Psychologi | 2015 |
Effect of propranolol on capsular reaction around silicone implants in guinea pigs.
Topics: Adrenergic beta-Antagonists; Animals; Breast Implants; Collagen Type I; Collagen Type III; Disease M | 2015 |
Toll-like receptor 9 plays a key role in the autonomic cardiac and baroreflex control of arterial pressure.
Topics: Animals; Arterial Pressure; Atropine Derivatives; Baroreflex; Behavior, Animal; Bradycardia; Cardiov | 2015 |
Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Arrhythmias, Cardiac; Disease Models, Animal; | 2015 |
Physical exercise affects attentional orienting behavior through noradrenergic mechanisms.
Topics: Adrenergic beta-Antagonists; Animals; Attention Deficit Disorder with Hyperactivity; Blotting, Weste | 2015 |
Memory of a drug lapse: Role of noradrenaline.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Animals; Basolateral | 2015 |
Predictive validity of endpoints used in electrophysiological modelling of migraine in the trigeminovascular system.
Topics: Action Potentials; Animals; Blood Pressure; Disease Models, Animal; Electric Stimulation; Fructose; | 2015 |
Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers.
Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Bupranolol; Disease Models, Animal; Female; Male; | 2015 |
Combined administration of propranolol + AG490 offers better effects on portal hypertensive rats with cirrhosis.
Topics: Acute-Phase Proteins; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Bacterial Trans | 2016 |
Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Cystathionine beta | 2015 |
The effects of acute and preventive migraine therapies in a mouse model of chronic migraine.
Topics: Acute Disease; Amiloride; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclin | 2016 |
Ocular Safety of Intravitreal Propranolol and Its Efficacy in Attenuation of Choroidal Neovascularization.
Topics: Adrenergic beta-Antagonists; Animals; Choroid; Choroidal Neovascularization; Disease Models, Animal; | 2015 |
Decrease of the insulin-like growth factor-1 bioavailability in spontaneously hypertensive rats with erectile dysfunction.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Cyclic GMP; Disease Models, Animal; Enzyme-Link | 2016 |
Pharmacokinetic-pharmacodynamic analyses of antihypertensive drugs, nifedipine and propranolol, in spontaneously hypertensive rats to investigate characteristics of effect and side effects.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Ca | 2016 |
[Effects of propranolol on oxygen-induced retinal neovascularization in mouse].
Topics: Animals; Dextrans; Disease Models, Animal; Endothelial Cells; Fluorescein-5-isothiocyanate; Injectio | 2016 |
The interaction between morphine and propranolol in chemical and electrical seizure models of mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrat | 2016 |
Sympathetic hyper-excitation in obesity and pulmonary hypertension: physiological relevance to the 'obesity paradox'.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Lung | 2016 |
Enhanced noradrenergic activity in the amygdala contributes to hyperarousal in an animal model of PTSD.
Topics: Adrenergic Neurons; Amygdala; Animals; Clenbuterol; Disease Models, Animal; Electroshock; Hippocampu | 2016 |
Psychological stress promotes neutrophil infiltration in colon tissue through adrenergic signaling in DSS-induced colitis model.
Topics: Adrenergic beta-Antagonists; Animals; Chemokines; Colitis; Disease Models, Animal; Inflammation; Inf | 2016 |
Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β2.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals | 2016 |
Neurotransmitter Mechanisms Underlying Sacral Neuromodulation of Bladder Overactivity in Cats.
Topics: Acetic Acid; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Cats; Disease Models, Anima | 2017 |
Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Resp | 2017 |
Immunological consequences of immunization with tumor lysate vaccine and propranolol as an adjuvant: A study on cytokine profiles in breast tumor microenvironment.
Topics: Adjuvants, Immunologic; Animals; Breast Neoplasms; Cancer Vaccines; Cell Line, Tumor; Cytokines; Dis | 2017 |
Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models.
Topics: Animals; Antihypertensive Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell | 2017 |
Physical training associated with Enalapril but not to Losartan, results in better cardiovascular autonomic effects.
Topics: Animals; Antihypertensive Agents; Atropine; Autonomic Nervous System; Baroreflex; Blood Pressure; Co | 2017 |
Daily propranolol administration reduces persistent injury-associated anemia after severe trauma and chronic stress.
Topics: Anemia; Animals; Bone Marrow; Contusions; Disease Models, Animal; Lung Injury; Male; Propranolol; Ra | 2017 |
Intralipid infusion ameliorates propranolol-induced hypotension in rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Antidotes; Blood Pressure; Disease Models, Animal; Fat Emulsio | 2008 |
Lacosamide, the new anticonvulsant, effectively reduces harmaline-induced tremors in rats.
Topics: Acetamides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Esse | 2008 |
Inflammatory factors that contribute to upregulation of ERG and cardiac arrhythmias are suppressed by CPU86017, a class III antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Aspartic Acid Endopeptidases; Berberine; Cardiomegaly | 2008 |
Propranolol transiently inhibits reinstatement of nicotine-seeking behaviour in rats.
Topics: Adrenergic beta-Antagonists; Animals; Behavior, Addictive; Disease Models, Animal; Extinction, Psych | 2010 |
The effects of beta-adrenoceptor antagonists on proinflammatory cytokine concentrations after subarachnoid hemorrhage in rats.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Butoxamine; Disease Mo | 2009 |
Physical exercise attenuates the cardiac autonomic deficit induced by nitric oxide synthesis blockade.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Atropine Derivatives; Autonomic Nervous | 2009 |
Blockade of adrenoreceptors inhibits the splenic response to stroke.
Topics: Adrenergic alpha-Antagonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Carbazol | 2009 |
Acute propranolol infusion stimulates protein synthesis in rabbit skin wound.
Topics: Adrenergic beta-Antagonists; Animals; Burns; Cell Cycle Proteins; Disease Models, Animal; DNA; Drug | 2009 |
Therapeutic effects of heme oxygenase-1 on psoriasiform skin lesions in guinea pigs.
Topics: Animals; Disease Models, Animal; Disease Progression; Enzyme Activation; Gene Expression Regulation; | 2009 |
Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: assessed using synchrotron radiation.
Topics: Adrenergic beta-Antagonists; Angiography; Animals; Disease Models, Animal; Hypertension, Pulmonary; | 2009 |
Distinct profiles of anxiety and dysphoria during spontaneous withdrawal from acute morphine exposure.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; | 2009 |
Improved bone status by the beta-blocker propranolol in an animal model of nutritional growth retardation.
Topics: Adrenergic beta-Antagonists; Animals; Bone and Bones; Disease Models, Animal; Drug Evaluation, Precl | 2009 |
MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Cyclic AMP-Dep | 2009 |
Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Body Weight; Cytokines; Di | 2009 |
Simultaneous blockade of alpha and beta adrenoceptors impairs cutaneous wound healing in rats.
Topics: Administration, Cutaneous; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cell | 2010 |
Pharmacological modifications of the stretch-induced effects on ventricular fibrillation in perfused rabbit hearts.
Topics: Action Potentials; Adenosine A2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Arr | 2009 |
Effect of early propranolol administration on portal hypertensive gastropathy in cirrhotic rats.
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Hypertension, Portal; Liver Cirrhosis, Experimental | 2009 |
The selective alpha1 adrenoceptor antagonist HEAT reduces L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; | 2010 |
Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; | 2009 |
The effect of propranolol on gene expression during the blood alcohol cycle of rats fed ethanol intragastrically.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Ethanol; Gene Ex | 2010 |
Evidence for the involvement of the serotonergic 5-HT2A/C and 5-HT3 receptors in the antidepressant-like effect caused by oral administration of bis selenide in mice.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Varianc | 2010 |
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Clonidine; Disease Mod | 2010 |
Ethanolic extracts of Brassica campestris spp. rapa roots prevent high-fat diet-induced obesity via beta(3)-adrenergic regulation of white adipocyte lipolytic activity.
Topics: Adipocytes, White; Adrenergic Agents; Animals; Anti-Obesity Agents; Brassica; Cyclic AMP-Dependent P | 2010 |
Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepro | 2010 |
Propranolol regulates cardiac transient outward potassium channel in rat myocardium via cAMP/PKA after short-term but not after long-term ischemia.
Topics: Adrenergic beta-Antagonists; Animals; Blotting, Western; Cyclic AMP; Cyclic AMP-Dependent Protein Ki | 2010 |
Blockade of sympathetic b-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model.
Topics: Acid Phosphatase; Adrenergic beta-Antagonists; Alveolar Bone Loss; Alveolar Process; Animals; Bacter | 2010 |
Is overall blockade superior to selective blockade of adrenergic receptor subtypes in suppressing left ventricular remodeling in spontaneously hypertensive rats?
Topics: Adrenergic Antagonists; Animals; Apoptosis; Bisoprolol; Blood Pressure; Carbazoles; Carvedilol; Dise | 2010 |
Combined blockade of β- and α₁-adrenoceptors in left ventricular remodeling induced by hypertension: beneficial or not?
Topics: Adrenergic Antagonists; Animals; Bisoprolol; Carbazoles; Carvedilol; Disease Models, Animal; Humans; | 2010 |
Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade.
Topics: Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Animals; Animals, Newborn; Blood-Retinal Barri | 2011 |
Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Sign | 2011 |
Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.
Topics: Adrenergic beta-Antagonists; Animals; Antigens, CD; beta Catenin; Biomechanical Phenomena; Cadherins | 2010 |
Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Cyproheptadine; Depression; Di | 2011 |
The effect of hyperthermia on blood glutamate levels.
Topics: Adrenergic beta-Antagonists; Animals; Autonomic Nervous System; Bicarbonates; Blood Glucose; Body Te | 2010 |
Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD.
Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Behavior, Animal; Cues; Disease Models, Animal; Heart | 2011 |
Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Hypertrophy, Left Ventricular; Kv | 2011 |
MicroRNA expression analysis: clinical advantage of propranolol reveals key microRNAs in myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expressi | 2011 |
Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses.
Topics: Analysis of Variance; Animals; Chemotherapy, Adjuvant; Disease Models, Animal; Etodolac; Female; Imm | 2011 |
Endocardial surface area tracking for assessment of regional LV wall deformation with 3D speckle tracking imaging.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Disease Model | 2011 |
Inhibition of β-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatement.
Topics: Adrenergic beta-Antagonists; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychologica | 2011 |
Does beta blockade postinjury prevent bone marrow suppression?
Topics: Adrenergic beta-Antagonists; Animals; Bone Marrow; Bone Marrow Diseases; Cells, Cultured; Disease Mo | 2011 |
Propranolol enhances cell cycle-related gene expression in pressure overloaded hearts.
Topics: Adrenergic beta-Antagonists; Animals; Cardiomyopathies; Disease Models, Animal; Echocardiography; Ge | 2011 |
Propranolol modulates the collateral vascular responsiveness to vasopressin via a G(α)-mediated pathway in portal hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Arginine Vasopressin; Collateral Circ | 2011 |
Beta-blockade prevents hematopoietic progenitor cell suppression after hemorrhagic shock.
Topics: Adrenergic beta-Antagonists; Animals; Bone Marrow; Disease Models, Animal; Hematopoietic Stem Cells; | 2011 |
Anti-tussive and bronchodilator mechanisms of action for the enaminone E121.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Airway Obstruction; Aniline Compounds; Anim | 2011 |
Paradoxical effect of noradrenaline-mediated neurotransmission in the antinociceptive phenomenon that accompanies tonic-clonic seizures: role of locus coeruleus neurons and α(2)- and β-noradrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; Animals; Disease Models, Animal; Dose-R | 2011 |
Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats.
Topics: Adrenergic beta-Antagonists; alpha-Methyltyrosine; Analgesics; Animals; Carrageenan; Chromatography, | 2011 |
Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by α- and β-adrenergic receptor antagonists in hemiparkinsonian rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Neurons; Animals; Behavior, An | 2012 |
Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agon | 2012 |
[Effect of different propranolol doses on skeletal structural and mechanic efficiency in an animal model of growth retardation].
Topics: Animals; Biometry; Bone Density; Bone Development; Disease Models, Animal; Dose-Response Relationshi | 2012 |
Models of cardiovascular disease: measurement of arrhythmogenic/antiarrhythmic activity in the guinea pig.
Topics: Animal Husbandry; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Protocols; Digoxin | 2009 |
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2012 |
Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling.
Topics: Adrenergic beta-Antagonists; Animals; Cell Line, Tumor; Cyclic AMP; Disease Models, Animal; Disease | 2012 |
In vivo β-adrenergic blockade by propranolol prevents isoproterenol-induced polycystic ovary in adult rats.
Topics: Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Female; Humans; Isoproterenol; Luteini | 2012 |
Characteristics of emodin on modulating the contractility of jejunal smooth muscle.
Topics: Animals; Atropine; Constipation; Diarrhea; Diphenhydramine; Disease Models, Animal; Dose-Response Re | 2012 |
Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Cardiotonic Agents; Creatine Kinase; Disease Mod | 2012 |
The effect of propranolol on aortic structure and function in normotensive rats.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Aortic Diseases; Blood | 2012 |
Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Angiopoietin-1; Angiopoietin-2; Animals; Animals, | 2012 |
Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Calcium Signaling | 2012 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; | 2012 |
Propranolol as antiangiogenic candidate for the therapy of hereditary haemorrhagic telangiectasia.
Topics: Activin Receptors, Type II; Adrenergic beta-Antagonists; Angiogenesis Inhibitors; Animals; Antigens, | 2012 |
Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats.
Topics: Animals; Antiparkinson Agents; Bile Ducts; Blood Pressure; Carbidopa; Carbon Tetrachloride; Disease | 2012 |
Fear conditioning can contribute to behavioral changes observed in a repeated stress model.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Conditioning, Psychological; Corticoster | 2012 |
The C57BL/6 genetic background confers cardioprotection in iron-overloaded mice.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Channels, L-Type; Disease Models, Animal; Disease Resi | 2013 |
Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model.
Topics: Adrenergic beta-Antagonists; Aging; Amyloid Neuropathies; Animals; Antihypertensive Agents; Biomarke | 2013 |
Is the sympathetic system involved in shock-induced gut and lung injury?
Topics: Adrenergic beta-Antagonists; Animals; Bone Marrow Cells; Cells, Cultured; Disease Models, Animal; Ga | 2012 |
Ivabradine but not propranolol delays the time to onset of ischaemia-induced ventricular fibrillation by preserving myocardial metabolic energy status.
Topics: Animals; Anti-Arrhythmia Agents; Benzazepines; Cyclic Nucleotide-Gated Cation Channels; Disease Mode | 2013 |
Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptor.
Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; | 2012 |
Propranolol reduces cognitive deficits, amyloid β levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration.
Topics: Adrenergic beta-Antagonists; Amyloid beta-Peptides; Animals; Cognition Disorders; Corticosterone; Di | 2013 |
Telmisartan plus propranolol improves liver fibrosis and bile duct proliferation in the PSC-like Abcb4-/- mouse model.
Topics: Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cas | 2013 |
Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor | 2013 |
Preservation of the baroreceptor heart rate reflex by chemical sympathectomy in experimental heart failure.
Topics: Adrenergic beta-Antagonists; Animals; Baroreflex; Blood Pressure; Body Weight; Bradycardia; Catechol | 2002 |
Influence of beta-adrenoceptor antagonists on hemorrhage-induced cellular immune suppression.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Anta | 2002 |
The sympathoadrenal system mediates the blood pressure and cardiac effects of human coagulation factor XII-related "new pressor protein".
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blood Pressure Determination; Blo | 2002 |
Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Caffeine; Calcium Ch | 2002 |
[Morphofunctional aspects of cardioprotective effect of propranolol in modelling of chronic ischemic heart disease].
Topics: Adrenergic beta-Antagonists; Animals; Calcium; Chronic Disease; Disease Models, Animal; Microscopy, | 2002 |
Combined beta-adrenergic and cholinergic antagonism produces behavioral and cognitive impairments in the water maze: implications for Alzheimer disease and pharmacotherapy with beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Alzheimer Disease; Analysis of Variance; Animals; Behavior, Animal; Cog | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
Role of sympathetic innervation in the defecation mechanism: a novel concept of its function.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anal Canal; Animals; Catheterization; Def | 2003 |
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation.
Topics: Animals; Bacteremia; Bacterial Infections; Disease Models, Animal; Female; Humans; Immunization; Imm | 2003 |
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation.
Topics: Animals; Bacteremia; Bacterial Infections; Disease Models, Animal; Female; Humans; Immunization; Imm | 2003 |
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation.
Topics: Animals; Bacteremia; Bacterial Infections; Disease Models, Animal; Female; Humans; Immunization; Imm | 2003 |
Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation.
Topics: Animals; Bacteremia; Bacterial Infections; Disease Models, Animal; Female; Humans; Immunization; Imm | 2003 |
Anterior hypothalamic beta-adrenergic activity in the maintenance of hypertension in aortic coarctated rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anterior Hypothalamic Nucleus; Aorti | 2004 |
Evidence favoring the use of an alpha2-selective vasopressor agent for cardiopulmonary resuscitation.
Topics: Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Press | 2003 |
Tracheal epinephrine or norepinephrine preceded by beta blockade in a dog model. Can beta blockade bestow any benefits?
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiopulmonary Resuscitation; Disease Models, Animal | 2003 |
The alteration of intracellular signaling on the smooth muscle cells contraction in cat esophagitis.
Topics: Acetylcholine; Acute Disease; Animals; Bridged-Ring Compounds; Cats; Disease Models, Animal; Drug An | 2004 |
A nitric oxide-releasing salbutamol elicits potent relaxant and anti-inflammatory activities.
Topics: Albuterol; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage; Bronchodilator Agents; Cell Mo | 2004 |
Increased tracheal responsiveness to beta-adrenergic agonist and antagonist in ovalbumin-sensitized guinea pigs.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aerosols; Animals | 2004 |
Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amiloride; Ani | 2004 |
Do incremental increases in blood pressure elicit neointimal plaques through endothelial injury?
Topics: Aging; Animals; Aorta, Abdominal; Arginine; Blood Pressure; Chickens; Disease Models, Animal; Endoth | 2004 |
Intestinal absorption and hepatic extraction of propranolol and metoprolol in rats with bilateral ureteral ligation.
Topics: Adrenergic beta-Antagonists; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Glucok | 2004 |
Involvement of CB1-receptors and beta-adrenoceptors in the regional hemodynamic responses to lipopolysaccharide infusion in conscious rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Consciousness; Disease Models, Animal; Drug In | 2005 |
The role of peripheral 5HT2A and 5HT1A receptors on the orofacial formalin test in rats with persistent temporomandibular joint inflammation.
Topics: Animals; Arthralgia; Arthritis; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pai | 2005 |
Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction.
Topics: Animals; Atropine; Autonomic Nervous System; Coronary Circulation; Disease Models, Animal; Exercise | 2005 |
Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; | 2005 |
Alterations of alpha-adrenergic modulations of coronary microvascular tone in dogs with heart failure.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood | 2005 |
A comparison of vasopressin and glucagon in beta-blocker induced toxicity.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Glucagon; Heart Rate; | 2006 |
A randomized comparison of manual, mechanical and high-impulse chest compression in a porcine model of prolonged ventricular fibrillation.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Cardiopulmonary Resuscitation; Cere | 2006 |
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Antibodies; Aorta; Ao | 2006 |
Alveolar fluid reabsorption is increased in rats with compensated heart failure.
Topics: Adrenalectomy; Adrenergic beta-Antagonists; Amiloride; Animals; Cardiac Output; Disease Models, Anim | 2006 |
A preliminary study on the cardioprotection of acupuncture pretreatment in rats with ischemia and reperfusion: involvement of cardiac beta-adrenoceptors.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Disease Models, Animal; Electroac | 2006 |
Beta2-Adrenergic agonists suppress rat autoimmune myocarditis: potential role of beta2-adrenergic stimulants as new therapeutic agents for myocarditis.
Topics: Adrenergic beta-Agonists; Animals; Autoimmune Diseases; Disease Models, Animal; DNA Primers; Ethanol | 2006 |
Pravastatin reverses the down-regulating effect of inflammation on beta-adrenergic receptors: a disease-drug interaction between inflammation, pravastatin, and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Biological Availability; C-Reactive | 2007 |
Differing effects of metoprolol and propranolol on large vessel and microvessel responsiveness in a porcine model of coronary spasm.
Topics: Acetylcholine; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Choline | 2006 |
beta-Adrenergic blockade during systemic inflammation: impact on cellular immune functions and survival in a murine model of sepsis.
Topics: Adrenergic beta-Antagonists; Animals; Cell Division; Cytokines; Disease Models, Animal; Immunity, Ce | 2007 |
Propranolol blocks chronic risperidone treatment-induced enhancement of spatial working memory performance of rats in a delayed matching-to-place water maze task.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; | 2007 |
Involvement of noradrenergic and corticoid receptors in the consolidation of the lasting anxiogenic effects of predator stress.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Associatio | 2007 |
Zhi-fuzi, a cardiotonic Chinese herb, a new medical treatment choice for portal hypertension?
Topics: Aconitum; Animals; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Drug Evaluation, Prec | 2007 |
Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticoste | 2008 |
Vascular effects of long-term propranolol administration after chronic nitric oxide blockade.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Biological Factors; Blood Pressure; Calcium; | 2007 |
Preserving cardiac output with beta-adrenergic receptor blockade and inhibiting the Bezold-Jarisch reflex during resuscitation from hemorrhage.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Bradycardia; Cardiac Output; Disease Models, A | 2007 |
Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: assessed using synchrotron radiation microangiography.
Topics: Adrenergic beta-Antagonists; Angiography; Animals; Arterioles; Chronic Disease; Disease Models, Anim | 2008 |
The role of fat emulsion therapy in a rodent model of propranolol toxicity: a preliminary study.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Electrocardiography; Fat E | 2006 |
Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety.
Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Behavior, Animal; Cocaine; Disease Models, Animal; Di | 2008 |
Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome.
Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Dogs; Epinephrine | 2008 |
A trial study of propranolol and Zhigancao decoction on the central depressant and anti-osteoporosic action in ovariectomized rats.
Topics: Adrenergic beta-Antagonists; Animals; Bone Density; Disease Models, Animal; Drugs, Chinese Herbal; F | 2008 |
Administration of angiotensin II in the paraventricular nucleus protects gastric mucosa from ischemia-reperfusion injury.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Disease M | 2008 |
Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats.
Topics: Animals; Calcineurin; Cardiotonic Agents; Disease Models, Animal; Endothelin Receptor Antagonists; E | 2008 |
Effect of early propranolol treatment in an animal model of congestive cardiomyopathy. II. beta-adrenergic receptors and left ventricular function.
Topics: Animals; Cardiomyopathy, Dilated; Disease Models, Animal; Heart; Heart Failure; Heart Ventricles; Pr | 1984 |
Antihypertensive activity of bucumolol, a beta-adrenergic blocking agent, in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Coumarins; Disease Models, Animal; Hypertensio | 1981 |
A lysosomal study of cold-induced hyperthyroidism in the rat: comparison to human hyperthyroid tissue.
Topics: Animals; Cathepsin D; Cathepsins; Cerebroside-Sulfatase; Cold Temperature; Disease Models, Animal; G | 1983 |
[Effect of central effective substances on alcohol preference].
Topics: Alcohol Drinking; Alcoholism; Animals; Arecoline; Atropine; Central Nervous System Stimulants; Cypro | 1983 |
The behavioral effect of salbutamol (a beta-adrenergic receptor stimulant) on reserpine- and propranolol-treated rats.
Topics: Albuterol; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Propranolol; | 1983 |
Effect of hormones on hepatocyte gluconeogenesis in different models of acute uraemia.
Topics: Acute Kidney Injury; Animals; Blood Glucose; Bucladesine; Dihydroxyacetone; Disease Models, Animal; | 1982 |
Effect of early propranolol treatment in an animal model of congestive cardiomyopathy: I Mortality and Ca2+ transport in sarcoplasmic reticulum.
Topics: Animals; Biological Transport, Active; Calcium; Cardiomyopathy, Dilated; Disease Models, Animal; Hea | 1984 |
[The abnormal ECG and the appearance of methacholine-induced arrhythmias in SART mice and effects of beta-blockers, oxprenolol, propranolol, and carteolol].
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Carteolol; Disease Models, Animal; | 1984 |
[Evaluation of the antianginal action of pharmacological substances by the change in the initiation threshold for myocardial ischemia in conscious rabbits].
Topics: Angina Pectoris; Animals; Coronary Circulation; Coronary Disease; Dipyridamole; Disease Models, Anim | 1984 |
[Attempt at an experimental validation of chalone treatment of erythremia].
Topics: Animals; Bone Marrow; Disease Models, Animal; Drug Evaluation, Preclinical; Erythrocytes; Growth Inh | 1981 |
Mechanisms of methacholine-induced coronary vasospasm in an experimental model of variant angina in the anesthetized rat.
Topics: Angina Pectoris, Variant; Animals; Atropine; Blood Pressure; Coronary Circulation; Coronary Vasospas | 1984 |
Evaluation of drugs for arrest of premature labor in a new animal model.
Topics: Albuterol; Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Dr | 1984 |
[Ataxia in rolling mouse Nagoya and the norepinephrine system--a psychopharmacological study].
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Cerebellar Ataxia; Disease Mod | 1982 |
Disparate effects of prazosin and propranolol on lipid metabolism in a rat model.
Topics: Animals; Cholesterol; Disease Models, Animal; Hypertension; Lipid Metabolism; Lipoproteins, VLDL; Ma | 1983 |
The B-aminopropionitrile-fed turkey: a model for detecting potential drug action on arterial tissue.
Topics: Aminopropionitrile; Animals; Aorta, Abdominal; Aortic Aneurysm; Aortic Diseases; Disease Models, Ani | 1983 |
Ventricular fibrillation in a conscious canine model--its prevention by UM-272.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Electrocardiography; Male; Myocardial | 1983 |
A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Chlorisondamine; Disease Models, Animal; Hypotensi | 1983 |
Experimental automaticity induced by mechanical lesion in rat isolated right ventricle: the effects of quinidine, phenytoin, and propranolol.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Female; Male; Phenyto | 1982 |
Barbiturate dependence in mice: effects of propranolol on the withdrawal syndrome.
Topics: Animals; Barbiturates; Disease Models, Animal; Humans; Isomerism; Male; Mice; Mice, Inbred C57BL; Pr | 1980 |
[Effects of antiarrhythmic agents on ventricular arrhythmias following myocardial infarct induced with glass beads in dogs (author's transl)].
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, | 1981 |
Digoxin-induced ventricular arrhythmias in the guinea pig heart in vivo: evidence for a role of endogenous catecholamines in the genesis of delayed afterdepolarizations and triggered activity.
Topics: Adenosine; Analysis of Variance; Animals; Arrhythmias, Cardiac; Catecholamines; Digoxin; Disease Mod | 1995 |
The effects of dobutamine, propranolol and nitroglycerin on an experimental canine model of congestive heart failure.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Dobutamine; D | 1994 |
Induction of psoriasiform changes in guinea pig skin by propranolol.
Topics: Abscess; Administration, Oral; Alopecia; Animals; Disease Models, Animal; Epidermis; Female; Freund' | 1994 |
Effects of adrenoceptor blockers on the cardiorespiratory response to nicotine in rats.
Topics: Animals; Disease Models, Animal; Drug Interactions; Hemodynamics; Male; Nicotine; Prazosin; Premedic | 1993 |
Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat.
Topics: Animals; Blood Glucose; Disease Models, Animal; Dogs; Epinephrine; Hyperglycemia; Male; Nicotine; Pr | 1993 |
Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice.
Topics: Adenylyl Cyclases; Adipose Tissue; Adipose Tissue, Brown; Adrenergic beta-Agonists; Adrenergic beta- | 1994 |
Pharmacological actions of SDZ 218-135, a novel positive inotropic agent.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Model | 1994 |
Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations.
Topics: Aconitine; Animals; Arrhythmias, Cardiac; Dialysis; Disease Models, Animal; Dogs; Dose-Response Rela | 1994 |
Effects of tilisolol on ischemic myocardial metabolism in dogs.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Carbohydrate Metabolism; Coronary Vess | 1994 |
Involvement of thromboxane A2 in propranolol-induced bronchoconstriction after allergic bronchoconstriction in guinea pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bridged Bicyclo Compounds; Bronch | 1994 |
Effects of beta-blockers and Ca(2+)-antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest.
Topics: Adenine Nucleotides; Animals; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dobutamine | 1993 |
[Refinement of a new Doppler sensor for studying fetal hemodynamic disorders (animal model)].
Topics: Animals; Cerebrovascular Circulation; Disease Models, Animal; Female; Fetal Hypoxia; Fetal Monitorin | 1993 |
The effect of hypertensive episodes and cardiac hypertrophy on the canine cardiac baroreflex.
Topics: Analysis of Variance; Animals; Baroreflex; Blood Pressure; Body Weight; Disease Models, Animal; Dogs | 1994 |
Effects of coronary artery occlusion and reperfusion on the idioventricular rate in anesthetized dogs.
Topics: Analysis of Variance; Animals; Coronary Disease; Disease Models, Animal; Dogs; Heart Block; Heart Ra | 1994 |
A stable model of left ventricular dysfunction in an intact animal assessed with high fidelity pressure and cinemagnetic resonance imaging.
Topics: Anesthesia; Animals; Atropine; Disease Models, Animal; Dogs; Halothane; Heart Diseases; Hemodynamics | 1993 |
Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyper | 1993 |
1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives.
Topics: Administration, Oral; Angina Pectoris; Animals; Anti-Arrhythmia Agents; Blood Pressure; Disease Mode | 1993 |
Efficacy of the class III antiarrhythmic agent azimilide in rodent models of ventricular arrhythmia.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chloroform; Constriction; Cor | 1996 |
Hemodynamic effects of calcium chloride in a canine model of acute propranolol intoxication.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Bradycardia; Calcium Chloride; Disease Models, | 1996 |
Experimental study of the detrimental effect of dopamine/glucagon combination in d,l-propranolol intoxication.
Topics: Adrenergic beta-Antagonists; Animals; Blood Gas Analysis; Blood Pressure; Calcium; Disease Models, A | 1996 |
An experimental model to study intracranial hypertension-induced vomiting in conscious dogs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Disease Models | 1996 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepi | 1996 |
Differential effect of selected antiarrhythmic drugs on coronary artery ligation-induced ventricular arrhythmias on the right or left sides.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Disease Models, Animal; Dogs; Female; Ligation; M | 1995 |
Hemodynamic effects of different pacing ratios in chronic dynamic double cardiomyoplasty.
Topics: Acute Disease; Animals; Cardiac Pacing, Artificial; Cardiomyoplasty; Chronic Disease; Disease Models | 1996 |
Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Antigens; Ast | 1996 |
Hemodynamic effects of cardiomyoplasty in an experimental model of acute heart failure and atrial fibrillation.
Topics: Acetylcholine; Animals; Atrial Fibrillation; Blood Pressure; Cardiac Output; Cardiomyoplasty; Diseas | 1996 |
Hemodynamic effects of pyruvate infusion in dogs.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Dogs; Dose-Response Relationship, D | 1995 |
Experimental psoriasis models.
Topics: Animals; Disease Models, Animal; Guinea Pigs; Propranolol; Psoriasis; Rats; Species Specificity | 1997 |
Insulin improves survival in a canine model of acute beta-blocker toxicity.
Topics: Acute Disease; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Antidotes; Disease Mo | 1997 |
[The neurophysiological effects of the beta-blocker obzidan in the modelling of emotional stress].
Topics: Adrenergic beta-Antagonists; Animals; Brain; Disease Models, Animal; Emotions; Male; Propranolol; Ra | 1997 |
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Ani | 1997 |
Hemodynamic effects of chronic tetrandrine and propranolol administration on portal hypertensive rats.
Topics: Administration, Oral; Alkaloids; Analysis of Variance; Animals; Antihypertensive Agents; Benzylisoqu | 1997 |
Beta-adrenoceptor-stimulated renin release is blunted in old rats.
Topics: Aging; Animals; Disease Models, Animal; Male; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Ad | 1998 |
Effects of chronic application of propranolol on beta-adrenergic signal transduction in heart ventricles from myopathic BIO TO2 and control hamsters.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Cardiomyopathies; Cricetinae; Disease Model | 1998 |
Calcium equally increases the internal calcium recirculation fraction before and after beta-blockade in canine left ventricles.
Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Calcium; Calciu | 1997 |
Propofol does not affect the canine cardiac conduction system under autonomic blockade.
Topics: Anesthetics, Intravenous; Animals; Atrioventricular Node; Atropine; Autonomic Nerve Block; Blood Pre | 1999 |
Increased angiogenesis in portal hypertensive rats: role of nitric oxide.
Topics: Adrenergic beta-Antagonists; Animals; Body Weight; Disease Models, Animal; Hypertension, Portal; Ima | 1999 |
A new, simple method for measuring mucociliary clearance in guinea-pigs.
Topics: Adrenergic beta-Antagonists; Air Pollutants; Albuterol; Animals; Disease Models, Animal; Guinea Pigs | 1999 |
Propranolol blocks cocaine-induced cerebral vasodilation in newborn sheep.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Blood Flow Velocity; Cerebrovascular Circula | 1999 |
The effect of sympatholytics on uncontrolled hemorrhage.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Drug The | 1999 |
Difference in bronchoprotective effects of bronchodilators on postallergic propranolol-induced bronchoconstriction.
Topics: Airway Resistance; Albuterol; Aminophylline; Animals; Atropine; Bronchi; Bronchial Hyperreactivity; | 1999 |
Pulmonary morphofunctional effects of acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Blood Gas Analysis; Disease Models, Animal; Elasticity; Lung; | 1999 |
In vivo airway eosinophil accumulation does not enhance antigen- or propranolol-induced bronchoconstriction in guinea pigs.
Topics: Administration, Inhalation; Administration, Intranasal; Animals; Antigens; Asthma; Bronchoconstricti | 1999 |
The role of cromakalim and a nitric oxide synthase blocker in cardiac arrhythmia in the intact baboon model.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Catheterization; Cromakalim; Disease Mod | 2000 |
Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agent | 2000 |
Regulation of liver and kidney glucose-6-phosphatase gene expression in hemorrhage and resuscitation.
Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Northern; Disease Models, Animal; Gene Expre | 2000 |
The effect of sodium bicarbonate on propranolol-induced cardiovascular toxicity in a canine model.
Topics: Animals; Bicarbonates; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Dogs; Electr | 2000 |
Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Calcium-Binding Proteins; Cardiomegaly; Dis | 2000 |
Impaired elimination of propranolol due to right heart failure: drug clearance in the isolated liver and its relationship to intrinsic metabolic capacity.
Topics: Animals; Chromatography, High Pressure Liquid; Constriction; Cytochrome P-450 Enzyme System; Disease | 2000 |
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature | 2001 |
Mechanisms of the increased pressor response to vasopressors in the mesenteric bed of nitric oxide-deficient hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; D | 2001 |
Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Disease Models, A | 2000 |
Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Caffeine; Calc | 2001 |
Systemic and splanchnic hemodynamics following hemorrhage and volume restitution with Haemaccel in portal hypertensive rats: the effect of propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Heart | 2001 |
Load versus humoral activation in the genesis of early hypertensive heart disease.
Topics: Angiotensin II; Animals; Catecholamines; Diastole; Disease Models, Animal; Dogs; Endothelin-1; Heart | 2001 |
Effect of endogenous catecholamine on myocardial stunning in a simulated ischemia model.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Carbac | 2001 |
Determination of propranolol concentration in small volume of rat plasma by HPLC with fluorometric detection.
Topics: Adrenergic beta-Antagonists; Animals; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Di | 2001 |
In vivo electrophysiologic studies in endothelial nitric oxide synthase (eNOS)-deficient mice.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Digoxin; Disease Models, Animal; Disease Susceptibility; El | 2001 |
Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Ascorbic Acid; Carbazoles; Cardi | 2002 |
Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor.
Topics: Adrenergic beta-Antagonists; Animals; Calcium; Cardiac Pacing, Artificial; Diastole; Disease Models, | 2002 |
Endovascular stimulation within the left pulmonary artery to induce slowing of heart rate and paroxysmal atrial fibrillation.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Atrial Fibrillation; Atropine; Autonomic Nervou | 2002 |
Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction.
Topics: Allopurinol; Animals; Blood; Coronary Disease; Disease Models, Animal; Dogs; Heart; Hemodynamics; Hy | 1976 |
beta-Adrenergic blockade reduces the severity of acute renal failure in rats.
Topics: Acute Kidney Injury; Adrenergic beta-Antagonists; Angiotensin II; Animals; Creatinine; Disease Model | 1976 |
Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Chymotrypsin; Disease Models, Animal; Epinephri | 1977 |
[Effects of kitchen salt and beta sympatholytics on the course of blood pressure in the hereditary, spontaneously hypertensive rat (SH rats, Münster strain)].
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Disease Models, Animal; Hypertension; Metoprol | 1977 |
Pharmacology of Sch 11973, N-(2-phenylisopropyl)-N-p-toluene sulfonyl urea, a potential new antianginal agent.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Coronary Disease; Dipyridamole; Disease Model | 1977 |
[Beta-blockers: redistribution of coronary blood flow and experimental myocardial ischaemia].
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Coronary Circulation; Coronary Disease; Disease Mode | 1978 |
Reduction in severity of acute renal failure in rats by beta-adrenergic blockade.
Topics: Acute Kidney Injury; Animals; Blood Specimen Collection; Creatinine; Disease Models, Animal; Drug Th | 1975 |
An in vitro model of canine immediate-type hypersensitivity reactions.
Topics: Animals; Antigens; Ascaris; Carbachol; Cromolyn Sodium; Disease Models, Animal; Dogs; Guanidines; Hi | 1976 |
The isoproterenol stress test in unanesthetized atherosclerotic rabbits.
Topics: Animals; Arteriosclerosis; Coronary Disease; Dipyridamole; Disease Models, Animal; Electrocardiograp | 1978 |
[Proceedings: Prevention of myocardial degeneration in a disease model of hereditary cardiomyopathy].
Topics: Animals; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Heart; Myocard | 1975 |
Effect of chronic administration of propranolol on the blood pressure and heart weight in experimental renal hypertension.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Renal; Male; Propranolo | 1976 |
A comparison between propranolol and hypothermia in preventing ischemic contracture of the left ventricle (stone heart).
Topics: Animals; Cardiomegaly; Coronary Disease; Disease Models, Animal; Dogs; Heart Arrest; Hypothermia, In | 1978 |
Effect of propranolol on regional myocardial function in anesthetized open-chest dogs with myocardial ischemia.
Topics: Animals; Blood Pressure; Coronary Disease; Disease Models, Animal; Dogs; Heart Rate; Hemodynamics; M | 1978 |
Epinephrine elevation in plasma parallels canine cardiac hypertrophy.
Topics: Animals; Aorta; Arteries; Cardiomegaly; Catheters, Indwelling; Constriction; Disease Models, Animal; | 1978 |
A new animal model for schizophrenia: interactions with adrenergic mechanisms.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Disease Models, Animal; Ditiocarb; Drug Antagonism; Dr | 1978 |
Effects of propranolol, minoxidil, and clofibrate on cholesterol-induced atherosclerosis in stumptail macaques (Macaca arctoides).
Topics: Animals; Aorta; Arteriosclerosis; Cholesterol; Clofibrate; Coronary Disease; Coronary Vessels; Diet, | 1977 |
The unbalanced heart. Animal models of cardiac dysrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Denervation; Disease Models, Animal; Electr | 1979 |
An opposing role for the adrenals in the hypotensive effects of propranolol in the spontaneously hypertensive rat.
Topics: Adrenal Glands; Adrenalectomy; Animals; Blood Pressure; Corticosterone; Disease Models, Animal; Hear | 1979 |
Ketamine block of bronchospasm in experimental canine asthma.
Topics: Airway Resistance; Anesthesia, Intravenous; Animals; Antigens; Ascaris; Asthma; Bronchial Spasm; Dis | 1979 |
Mechanisms of beneficial effects of vasodilators and inotropic stimulation in the experimental failing ischemic heart.
Topics: Animals; Cardiac Output; Collateral Circulation; Coronary Circulation; Coronary Disease; Coronary Ve | 1978 |
Beneficial actions of N-dimethyl propranolol on myocardial oxygen balance and transmural perfusion gradients distal to a severe coronary artery stenosis in the canine heart.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Drug | 1978 |
Arterial hypertension induced by femoral lengthening. A canine model.
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Bone Lengthening; Disease Models, Animal; Dogs; Femur; | 1978 |
[The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)].
Topics: Animals; Blood Pressure; Chromonar; Coronary Circulation; Coronary Disease; Coumarins; Disease Model | 1976 |
Effects of vagal stimulation, atropine, and propranolol on fibrillation threshold of normal and ischemic ventricles.
Topics: Animals; Atropine; Coronary Vessels; Disease Models, Animal; Dogs; Electric Stimulation; Electrocard | 1977 |
Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Diet, Sodium-Restricted; Disease Models, Animal; Drink | 1977 |
Effect of regional myocardial ischaemia on left ventricular isovolumic contraction.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Femal | 1977 |
Alleviation of anoxic experimental acute renal failure in rats by beta-adrenergic blockade.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Disease Models, Animal; Dose-Response Relationship, Dr | 1977 |
Infarct size reduction by propranolol before and after coronary ligation in dogs.
Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; Hemodynamics; Male; Myocardial I | 1977 |
[Significance of renin-angiotensin system inhibitors in the diagnosis of hypertension].
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Dogs; Enzyme Inhibitors; Humans; Hy | 1977 |
[Effect of propranolol on haemaodynamics and extent of ischaemic damage of the myocardium in experimental infarction (author's transl)].
Topics: Animals; Disease Models, Animal; Dogs; Hemodynamics; Myocardial Infarction; Propranolol | 1976 |
Propranolol in experimental myocardial ischemia: dissociation of effects on contraction and epicardial ST segments.
Topics: Animals; Blood Pressure; Depression, Chemical; Disease Models, Animal; Dogs; Electrocardiography; He | 1976 |
A new model of stress ulcer in the rat with pylorus ligation and its pathogenesis.
Topics: Amylopectin; Animals; Atropine; Bicarbonates; Chlorpromazine; Disease Models, Animal; Gastric Mucosa | 1976 |
Use of changes in the epicardial QRS complex to assess interventions which modify the extent of myocardial necrosis following coronary artery occlusion.
Topics: Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Evaluation Studies as Topic; Fe | 1976 |
Ischemic changes in the canine heart as affected by the dimethyl quaternary analog of propranolol, UM-272 (SC-27761).
Topics: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Disease; Disease Models, Ani | 1976 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Mal | 1976 |
Significance of spinal autonomic loci in post coronary ligation arrhythmia.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Catecholamines; Chloralose; Chlorisondamine | 1976 |
Hypothesis for rational therapy in acute stroke.
Topics: Acute Disease; Aminophylline; Animals; Cerebrovascular Disorders; Disease Models, Animal; Drug Evalu | 1976 |
Effect of propranolol and phenylbutazone on the prostaglandin like activity of the rabbit's iris in endotoxin induced iritis.
Topics: Animals; Disease Models, Animal; Endotoxins; Female; Iris; Iritis; Male; Phenylbutazone; Propranolol | 1976 |
Effect of propranolol on blood pressure in normal and hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Hypertension; Hypertension, Renal; Prop | 1975 |
Experimental cerebral vasospasm. Part 2: effects of vasoactive drugs and sympathectomy on early and late spasm.
Topics: Animals; Circle of Willis; Disease Models, Animal; Dogs; Ischemic Attack, Transient; Isoxsuprine; Me | 1975 |
Effects of several antianginal agents on pacing-induced S-T Segment depression in the atherosclerotic rabbit.
Topics: Angina Pectoris; Animals; Arteriosclerosis; Autonomic Agents; Cardiac Catheterization; Chromonar; De | 1975 |
Control of acute aortic dissection.
Topics: Animals; Aorta; Aortic Aneurysm; Blood Pressure; Depression, Chemical; Disease Models, Animal; Dogs; | 1975 |
Evaluation of antihypertensive agents in the stress-induced hypertensive rat.
Topics: Animals; Antihypertensive Agents; Chlorisondamine; Disease Models, Animal; Drug Evaluation, Preclini | 1975 |
Proceedings: Effect of chronic oral administration of propranolol on spontaneously and renal hypertension rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Hypertension; Hypertension, Renal; Male; Prop | 1975 |
Pharmacological modification of arrhythmias after experimentally induced acute myocardial infarction. Drugs acting on the nervous system.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Chlordiaz | 1975 |
Method for the production of severe ventricular dysrhythmias in small laboratory animals.
Topics: Animals; Animals, Laboratory; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Desoxycorticosterone; Di | 1975 |
[The phenomenon of experimental motor retardation as one of the manifestations of the Parkinsonian syndrome].
Topics: Amphetamine; Animals; Catecholamines; Cats; Caudate Nucleus; Chlorpromazine; Dihydroergotoxine; Dise | 1975 |
On the nature of protection by propranolol against myocardial necrosis after temporary coronary occlusion in dogs.
Topics: Animals; Coronary Disease; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electroca | 1976 |
Metabolic evaluation of agents designed to protect the ischemic myocardium and to reduce infarct size.
Topics: Animals; Coronary Circulation; Coronary Disease; Disease Models, Animal; Heart; Hemodynamics; Lysoso | 1976 |
[The antidepressive properties of anaprilin].
Topics: Animals; Antidepressive Agents; Clonidine; Depression; Disease Models, Animal; Dose-Response Relatio | 1992 |
[Electromechanical responsiveness to alpha 1-adrenoceptor and angiotensin II receptor stimulation in the ventricular myocardium of hypertrophied and dilated cardiomyopathic Syrian hamsters].
Topics: Action Potentials; Angiotensin II; Animals; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; C | 1992 |
Propranolol reduces myocardial hypertrophy in the right cardiac chambers after infarction in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Hypertro | 1992 |
Effects of tertatolol, a beta-adrenoceptor antagonist with agonist affinity at 5-HT1A receptors, in an animal model of migraine: comparison with propranolol and pindolol.
Topics: Adrenergic beta-Antagonists; Animals; Carotid Arteries; Disease Models, Animal; Hemodynamics; Inject | 1992 |
Cardioprotective effects of carvedilol, a novel beta adrenoceptor antagonist with vasodilating properties, in anaesthetised minipigs: comparison with propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Carbazoles; Carvedilo | 1992 |
Autonomic nervous system dysfunction alters drug effects: implications for testing drugs for the treatment of heart failure.
Topics: Animals; Autonomic Nervous System; Cardiovascular Agents; Disease Models, Animal; Enalapril; Heart F | 1992 |
Left ventricular contractility and energetic cost in disease models--an approach from the pressure-volume diagram.
Topics: Animals; Calcium; Disease Models, Animal; Dogs; Epinephrine; Heart Diseases; Myocardial Contraction; | 1992 |
[Effects of alpha and beta receptor blockaders on urinary excretion of sodium and potassium in healthy rats and in those with chronic renal failure].
Topics: Animals; Disease Models, Animal; Glomerular Filtration Rate; Kidney Failure, Chronic; Models, Biolog | 1992 |
Inhibitory effect of NZ-107 on anaphylactic bronchoconstriction in guinea pigs and rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Anaphylaxis; Anim | 1992 |
[The characteristics of the adrenergic mechanisms regulating the lymph flow in arterial hypertension in dogs].
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Disease Models, Animal; Dogs; Epinephrine; Female; | 1991 |
Efficacy of the glyceryl trinitrate transdermal therapeutic system in a dog model of heart failure.
Topics: Administration, Cutaneous; Animals; Cardiac Output; Dextrans; Disease Models, Animal; Dogs; Female; | 1991 |
Isolated paced guinea pig left atrium: a new ouabain-induced arrhythmia model.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Function, Left; Clonidine; Disease Mod | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationshi | 1991 |
Studies on active transport of (E)-10-hydroxynortriptyline in the kidney and brain of rats: effects of propranolol and quinidine.
Topics: Animals; Biological Transport, Active; Brain; Disease Models, Animal; Kidney; Male; Metabolic Cleara | 1991 |
[Effect of obsidan on metabolic processes in the blood and lymph in acute myocardial infarction].
Topics: Acid-Base Equilibrium; Animals; Disease Models, Animal; Dogs; Electrolytes; Glucose; Lactates; Lymph | 1991 |
Serum angiotensin converting enzyme activity and plasma renin activity in experimental models of rats.
Topics: Animals; Disease Models, Animal; Hypertension, Renovascular; Isoproterenol; Kidney Diseases; Male; N | 1990 |
Insulin and beta adrenergic effects during endotoxin shock: in vivo myocardial interactions.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Female; Glucose; Insulin; Insulin Resistance; | 1990 |
Effects of dopexamine hydrochloride on hypoxic pulmonary vasoconstriction in isolated rat lung.
Topics: Animals; Dinoprost; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hypoxia; Lun | 1990 |
Effects of propranolol on gastric microcirculation and acid secretion in portal hypertensive rats.
Topics: Animals; Disease Models, Animal; Drug Interactions; Gastric Acid; Gastric Mucosa; Hypertension, Port | 1990 |
Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; C | 1989 |
Effect of propranolol on the myocardial contractility of normotensive and spontaneously hypertensive rabbits: relationship of pharmacokinetics and pharmacodynamics.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension; Myocardial Contraction; Propranolol; | 1989 |
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets.
Topics: Animals; Animals, Newborn; Chlorpromazine; Clonidine; Diarrhea; Disease Models, Animal; Escherichia | 1989 |
Role of noradrenergic system in limbic seizures induced by pilocarpine. I. Importance of beta-adrenergic receptor.
Topics: Albuterol; Animals; Disease Models, Animal; Lidocaine; Limbic System; Male; Pilocarpine; Propranolol | 1988 |
Regulation of coronary blood flow by counteraction of coronary vascular alpha and beta adrenergic activation during experimental pliable coronary stenosis.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Coronary Circulation; | 1986 |
Hemodynamic recovery during simulated ventricular tachycardia: role of adrenergic receptor activation.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiac Pacing, Artificial; Dise | 1988 |
Impaired inotropic responses to alpha-adrenergic stimulation in experimental left ventricular hypertrophy.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension, Renal; Isoproterenol; | 1985 |
Theophylline toxicity and the beta-adrenergic system.
Topics: Acidosis; Adolescent; Aminophylline; Animals; Catecholamines; Disease Models, Animal; Dogs; Female; | 1985 |
On the mechanism of renin release during experimental myocardial ischaemia.
Topics: Animals; Coronary Disease; Disease Models, Animal; Dogs; Female; Hemodynamics; Kidney; Male; Myocard | 1985 |
Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma.
Topics: Angiotensins; Animals; Blood Pressure; Cell Membrane; Disease Models, Animal; Dopamine; Heart Rate; | 1987 |
Beta-adrenergic blockade increases the hepatic extraction of glucose in sepsis.
Topics: Animals; Blood Glucose; Cholecystitis; Disease Models, Animal; Dogs; Epinephrine; Female; Gangrene; | 1986 |
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.
Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Bretylium Tosylate; Death, Sudden; Disease Models, Ani | 1986 |
Results of sympathetic denervation in the canine heart: supersensitivity that may be arrhythmogenic.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Female; Heart; Heart Ventricles; Male; | 1987 |
Impaired thickening of nonischemic myocardium during acute regional ischemia in the dog.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Coronary Circulation; Coronary Disease; Diastol | 1985 |
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease M | 1985 |
[An experimental animal model study on the effect of antiarrhythmic drugs for the prophylaxis of supraventricular tachycardia].
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Propranolol; Tachycardia; Verapamil | 1985 |
[Hypertension in rats caused by metyrapone and heat-stress treatment].
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Hot Temperature; Hypertension; Male; Metyrapone; P | 1985 |
Mechanisms of action of hypocapnic alkalosis on limb blood vessels in man and dog.
Topics: Alkalosis; Alkalosis, Respiratory; Animals; Blood Pressure; Carbon Dioxide; Diphenhydramine; Disease | 1972 |
Modification of myocardial infarct volume. An experimental study in the dog.
Topics: Animals; Arrhythmias, Cardiac; Arteries; Blood Pressure; Body Weight; Coronary Vessels; Disease Mode | 1973 |
[Anti-arrhythmic effects of a beta-adrenolytic agent dl (hydroxy 2't-butylamino-3' propyloxy) 8-thiochromane (S 2395)].
Topics: Adrenergic beta-Antagonists; Amino Alcohols; Animals; Anti-Arrhythmia Agents; Anura; Arrhythmias, Ca | 1973 |
Experiments upon the reflex mechanism of massive pulmonary embolism.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Blood Pressure; Disease Models, Animal; Electrocardi | 1969 |
[Clinical and experimental data on the action of blockaders of adrenergic beta-receptors in ectopic arrhythmias of the heart].
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Complexes, | 1969 |
Effects of oxyfedrine and ouabain on the heart-lung preparation of the dog.
Topics: Amino Alcohols; Animals; Arrhythmias, Cardiac; Cardiac Output; Disease Models, Animal; Dogs; Female; | 1973 |
Streptozotocin resistance of the genetically diabetic KK mouse.
Topics: Animals; Blood Glucose; Depression, Chemical; Diabetes Complications; Diabetes Mellitus; Disease Mod | 1974 |
Mechanisms regulating renin release in dogs with thoracic caval constriction.
Topics: Angiotensin II; Animals; Ascites; Blood Pressure; Constriction; Creatinine; Disease Models, Animal; | 1972 |
[Experimental asthma in guinea pigs and autonomic mediators].
Topics: Animals; Asthma; Atropine; Autonomic Agents; Cyclic AMP; Disease Models, Animal; Guinea Pigs; Hexame | 1972 |
Pharmacological studies on active bronchial anaphylaxis in the rat.
Topics: Aluminum Hydroxide; Anaphylaxis; Animals; Atropine; Bordetella pertussis; Bronchial Spasm; Cromolyn | 1974 |
Nutritional circulation in the heart. 3. Effect of isoproterenol and beta adrenergic blockade on myocardial hemodynamics and rubicium-86 extraction in the isolated supported heart preparation.
Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Animals; Blood Circulation; Blood Flow V | 1970 |
Alpha-adrenergic inhibition of immunoreactive insulin release during deep hypothermia.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Blood Pressure; B | 1971 |
Centrogenic cardiac arrhythmia induced by aconitine: a new "model" for screening of anti-arrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood | 1971 |
Protective effect of beta adrenoceptor blockade in experimental coronary occlusion in conscious dogs.
Topics: Acetanilides; Adrenergic beta-Antagonists; Amino Alcohols; Animals; Coronary Disease; Disease Models | 1972 |
Antihypertensive activity of four blocking agents in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Antihypertensive Agents; Blood Pressure; Clonidine | 1972 |
Some effects of propranolol on the cardiovascular responses of the monkey to simulated subarachnoid haemorrhage.
Topics: Animals; Arrhythmia, Sinus; Blood Pressure; Cerebrovascular Circulation; Disease Models, Animal; Ele | 1972 |
The effects of oligemic hypotension on myocardial function.
Topics: Animals; Anti-Arrhythmia Agents; Blood Gas Analysis; Coronary Circulation; Disease Models, Animal; D | 1973 |
Cardiovascular response to experimental spinal cord compression.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Cardiovascular System; Cats; Disease Models | 1973 |
The effect of reserpine and d,l-propranolol on digitalis-induced arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Cardanolides; Disease Models, Animal; Dogs; | 1973 |
Mechanisms regulating the cardiac output response to cyanide infusion, a model of hypoxia.
Topics: Animals; Aorta; Blood Pressure; Bretylium Compounds; Cardiac Output; Catheterization; Cyanides; Dise | 1973 |
[Reduction by propranolol of hypertension induced by dephrenation in the dog].
Topics: Animals; Cardiac Output; Denervation; Disease Models, Animal; Dogs; Heart Rate; Hypertension; Phreni | 1973 |
Prevention of gross myocardial infarction in the canine heart.
Topics: Animals; Assisted Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Heart Ventricles; Hyp | 1974 |
Effect of ischemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle.
Topics: Angina Pectoris; Animals; Carbon; Cesium Isotopes; Chromium Isotopes; Collateral Circulation; Corona | 1971 |
Left ventricular performance and coronary flow after coronary embolization with plastic microspheres.
Topics: Animals; Atropine; Blood Pressure; Cardiac Output; Coronary Circulation; Disease Models, Animal; Dog | 1971 |
Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion.
Topics: Animals; Coronary Disease; Coronary Vessels; Creatine Kinase; Disease Models, Animal; Dogs; Drug Com | 1972 |
Pharmacodynamic application of L-dopa in cardiogenic shock.
Topics: Animals; Aorta; Blood Pressure; Coronary Circulation; Dihydroxyphenylalanine; Disease Models, Animal | 1972 |
[Experimental study on drugs for the treatment of myocardial infarction].
Topics: Angiography; Animals; Benzyl Compounds; Body Weight; Carboxylic Acids; Dipyridamole; Disease Models, | 1972 |
Hemodynamics of early experimental renal hypertension in dogs. Normal limb blood flow, elevated limb vascular resistance, and decreased venous compliance.
Topics: Animals; Blood Pressure; Blood Volume; Diazoxide; Disease Models, Animal; Dogs; Femoral Vein; Foreli | 1972 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |
Experimental graded "pump failure" of the left ventricle.
Topics: Animals; Aorta, Thoracic; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cardiac Output; Cardi | 1971 |
Reduced effect of epinephrine on circulating eosinophils in asthma and after beta-adrenergic blockade or Bordetella pertussis vaccine. With a note on eosinopenia after methacholine.
Topics: Adult; Analysis of Variance; Animals; Asthma; Dibenzylchlorethamine; Disease Models, Animal; Eosinop | 1970 |
Dissociation of factors influencing myocardial degeneration and generalized cardiocirculatory failure.
Topics: Animals; Aspartic Acid; Cricetinae; Diet; Digitoxin; Disease Models, Animal; Edema; Epinephrine; Fem | 1969 |
A comparison of the effects of bretylium, lignocaine and propranolol on experimental cardiac arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Bretylium Compounds; Disease Models, Animal; Dogs; Epinephrine; Lidoc | 1969 |
Effects of beta-receptor blockade on the course of experimental hemorrhagic shock.
Topics: Acetone; Animals; Blood; Blood Glucose; Carbon Dioxide; Disease Models, Animal; Dogs; Hematocrit; He | 1969 |
Thyroid storm treatment with blood exchange and plasmapheresis.
Topics: Adolescent; Aged; Animals; Disease Models, Animal; Exchange Transfusion, Whole Blood; Female; Humans | 1970 |