propranolol and Coronary Disease studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Research Excerpts

Excerpt	Relevance	Reference
"Both amiodarone and beta-blockers have been shown to decrease the incidence of atrial fibrillation after cardiovascular surgery."	9.09	Amiodarone versus a beta-blocker to prevent atrial fibrillation after cardiovascular surgery. ( Greenberg, MD; Katz, NM; Kilborn, MJ; Solomon, AJ, 2001)
"In a randomized, double-blind study oral doses of 50 mg carvedilol (Dilatrend) were compared with 40 mg propranolol in 16 male patients with coronary heart disease, CHD [12 without significant stenoses following percutaneous transluminal coronary angioplasty (PTCA), 4 with multivessel disease]."	9.07	Acute hemodynamic effects of carvedilol in comparison with propranolol in patients with coronary heart disease. ( Wendt, T, 1992)
"The efficacy and safety of esmolol, an ultra-short-acting beta-adrenergic blocking agent (elimination half-life, 9 min), was investigated in 358 patients with supraventricular tachyarrhythmias (SVTs) in three multicenter studies (placebo-controlled, propranolol-controlled, and open-label baseline-controlled) and in 19 patients with myocardial ischemia (acute myocardial infarction or unstable angina) in a single-center, open-label study."	9.06	Clinical experience with esmolol, a short-acting beta-adrenergic blocker in cardiac arrhythmias and myocardial ischemia. ( Blanski, L; Kirshenbaum, J; Laddu, AR; MacCosbe, P; Sung, RJ; Turlapaty, P, 1986)
"The effects of the beta-adrenoceptor-blocking drugs propranolol, metoprolol, pindolol, and placebo, on mucociliary clearance were studied in three groups of 6 subjects with coronary heart disease and normal lung function."	9.05	Influence of propranolol, metoprolol, and pindolol on mucociliary clearance in patients with coronary heart disease. ( Dorow, P; Felix, R; Schiess, W; Schmutzler, H; Weiss, T, 1984)
"The effects of propranolol on lipids and lipoproteins were investigated in survivors of a recent myocardial infarction who were enrolled in the double-blind Beta-Blocker Heart Attack Trial."	9.05	Effects of propranolol on blood lipids and lipoproteins in myocardial infarction. ( Campbell, J; Capone, RJ; Hawkins, CM; Henderson, LO; Herbert, PN; McClure, D; Saritelli, A; Shulman, RS, 1983)
"The beta-Blocker Heart Attack Trial (BHAT) was a National Heart, Lung, and Blood Institute-sponsored, multicenter, randomized, double-blind, and placebo-controlled trial designed to test whether the regular administration of propranolol hydrochloride to men and women who had experienced at least one myocardial infarction would result in a significant reduction in total mortality during a two- to four-year period."	9.05	A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. ( , 1982)
"Despite widespread clinical application of propranolol (P) in angina pectoris, convincing evidence of its efficacy has been incomplete, thereby resulting in continued controversy."	9.04	Efficacy of beta adrenergic blockade in coronary heart disease: propranolol in angina pectoris. ( Amsterdam, EZ; Mason, DT; Miller, RR; Olson, HG; Pratt, CM, 1975)
"Although carvedilol attenuates left ventricular (LV) remodeling in coronary occlusion-reperfusion, it is not known whether it attenuates ischemic LV remodeling because of coronary stenosis (CS) or permanent coronary occlusion (CO)."	7.71	Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats. ( Maehara, K; Maruyama, Y; Sakabe, A; Yaoita, H, 2002)
"The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity."	7.68	Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats. ( Braquet, C; Köpernik, W; Mest, HJ; Rein, T; Riedel, A, 1992)
"The effect of adding propranolol to procainamide, quinidine, propafenone or disopyramide was prospectively evaluated in 37 patients, all with prior infarction and inducible ventricular tachycardia (VT)."	7.68	Effectiveness of propranolol added to a type I antiarrhythmic agent for sustained ventricular tachycardia secondary to coronary artery disease. ( Friehling, TD; Kowey, PR; Lipshutz, H; Marinchak, RA; Stohler, JL, 1990)
"The effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, on ischemic myocardial acidosis were studied in dog hearts, in which the left anterior descending coronary artery was partially occluded for 90 min, and were compared with those of atenolol and propranolol."	7.68	Betaxolol, a cardioselective beta-adrenoceptor antagonist, attenuates ischemic myocardial acidosis in dogs. ( Abe, Y; Narimatsu, A; Tobe, A, 1990)
"The antiarrhythmic activity of the calcium entry blockers, verapamil, nifedipine and prenylamine, was assessed against arrhythmias occurring during 20 min of acute occlusion, or upon rapid reperfusion of the left anterior descending coronary artery (LAD) in anesthetized pigs."	7.67	Acute coronary artery occlusion-reperfusion arrhythmias in pigs: antiarrhythmic and antifibrillatory evaluation of verapamil, nifedipine, prenylamine and propranolol. ( Bergey, JL; McCallum, JD; Nocella, K; Wendt, RL, 1984)
"In 59 patients with mild or moderate essential hypertension effects of propranolol and hydrochlorothiazide on serum lipids, fibrynogen, glucose and uric acid concentrations as well as serum euglobulins fibrynolysis time were studied."	7.67	[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension]. ( Karolko, B; Kawecka, M; Lukasik, S; Moszczyńska, J; Witkowska, M, 1989)
"Although congestive heart failure has been reported with the combination of a beta blocker and either verapamil or nifedipine, it has not previously been reported for combination therapy that includes diltiazem."	7.67	Combination therapy with diltiazem and propranolol: precipitation of congestive heart failure. ( Egan, T; McIntyre, KM; Parisi, AF; Strauss, WE, 1985)
"The effects of nadolol on experimental arrhythmias were investigated and compared with those of propranolol and alprenolol."	7.67	Anti-arrhythmic effect of nadolol in experimental arrhythmias: comparison with propranolol and alprenolol. ( Hashimoto, H; Nakashima, M; Oguro, K; Sogabe, K; Takiguchi, Y, 1985)
"Nifedipine was evaluated in the management of eight patients with intractable coronary arterial spasm."	7.66	Nifedipine therapy for refractory coronary arterial spasm. ( Heupler, FA; Proudfit, WL, 1979)
"On 51 of 53 occasions, sudden withdrawal of propranolol from patients with angina pectoris produced no substantial adverse effects."	7.65	Sudden withdrawal of propranolol in patients with angina pectoris. ( Myers, MG; Wisenberg, G, 1977)
"Clinical and hemodynamic benefits have been documented after giving diazepam to patients with coronary heart disease."	7.65	Systemic vasodilatation following diazepam after combined sympathetic and parasympathetic blockade in patients with coronary heart disease. ( Bourassa, MG; Côté, P; Noble, J, 1976)
"To determine whether the depression of left ventricular pumping activity associated with beta-blockade alone could be offset by a substantial degree of partial agonist activity, the haemodynamic dose-response effects of intravenous propranolol and pindolol were compared in a randomised between-group saline controlled study in twenty patients with angiographically proven coronary artery disease."	6.65	Comparative haemodynamic dose-response effects of intravenous propranolol and pindolol in patients with coronary heart disease. ( Ahuja, RC; Nelson, GI; Okoli, RC; Silke, B; Taylor, SH, 1983)
"Labetalol was followed by significant dose related decreases in systemic blood pressure and vascular resistance associated with a significant increase in cardiac output; heart rate and pulmonary artery occluded pressure were unchanged."	6.65	Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease. ( Ahuja, RC; Nelson, GI; Silke, B; Taylor, SH, 1982)
" In a double-blind study of ten patients with stable angina pectoris treated with nifedipine, propranolol, and atenolol, smoking was found to have direct and adverse effects on the heart and to interfere with the efficacy of all three antianginal drugs, but with that of nifedipine the most."	6.16	Smoking, catecholamines, and the ischemic myocardium. ( Fox, KM, 1988)
"Propranolol was administered in two equally divided doses 30 min before and 10 min after ligation of the anterior descending coronary artery (CAL) in anesthetized open-chest pigs."	5.28	Critical role of dose in protection by propranolol against ventricular fibrillation in a pig model of acute myocardial ischemia. ( Hamm, CW; Muller, CA; Opie, LH; Peisach, M; Pineda, CA; Thandroyen, FT, 1989)
"The number of reperfusion arrhythmias was also significantly lower in the treated animals."	5.27	Nifedipine with and without propranolol in the treatment of myocardial ischemia: effect on ventricular arrhythmias and recovery of regional wall function. ( ten Cate, FJ; Verdouw, PD; Wolffenbuttel, BH, 1983)
"Pretreatment with propranolol diminished the number of VA generated in the 1b phase but not those in the 1a phase; however, these differences were statistically not significant."	5.27	Effect of propranolol on early postischemia arrhythmias and noradrenaline and potassium release of ischemic myocardium in anesthetized pigs. ( Addicks, K; Bischoff, A; Hirche, H; Knopf, H; McDonald, FM, 1988)
"A distinct phase of ventricular arrhythmias was evident about 10 to 30 min after ligation."	5.27	Prevention of ventricular fibrillation by metoprolol in a pig model of acute myocardial ischaemia: absence of a major arrhythmogenic role for cyclic AMP. ( Gihwala, D; Hamm, CW; Muller, CA; Opie, LH; Peisach, M, 1986)
"The hypotensive effect of nifedipine (a Ca2+-antagonist) was studied in acute tests and during the long-term administration of the drug together with propranolol."	5.26	Hypotensive action of nifedipine (Ca2+-antagonist) and propranolol in acute trials and its long-term therapy of hypertensive coronary heart disease patients. ( Aoki, K; Kato, K; Kawaguchi, Y; Kondo, S; Mochizuki, A; Sato, K; Yamamoto, M, 1981)
"Both amiodarone and beta-blockers have been shown to decrease the incidence of atrial fibrillation after cardiovascular surgery."	5.09	Amiodarone versus a beta-blocker to prevent atrial fibrillation after cardiovascular surgery. ( Greenberg, MD; Katz, NM; Kilborn, MJ; Solomon, AJ, 2001)
" We studied the short effects of oral administration of nifedipine (10 mg) and propranolol (80 mg) alone and in combination in 15 elderly patients with chronic exertional angina pectoris in a double-blind, randomized, cross-over study."	5.07	[Acute effects of propranolol and its association with nifedipine in aged patients with effort stable angina. Randomized double-blind crossover study, under placebo control]. ( Cicatiello, AM; De Rosa, ML; Di Palma, A; Iannuzzi, L; Lirato, C; Pandolfi, E; Parlati, S; Santamaria, F; Sestito, M, 1993)
"In a randomized, double-blind study oral doses of 50 mg carvedilol (Dilatrend) were compared with 40 mg propranolol in 16 male patients with coronary heart disease, CHD [12 without significant stenoses following percutaneous transluminal coronary angioplasty (PTCA), 4 with multivessel disease]."	5.07	Acute hemodynamic effects of carvedilol in comparison with propranolol in patients with coronary heart disease. ( Wendt, T, 1992)
"In a randomized double-blind study, oral doses of 50 mg carvedilol were compared to 40 mg propranolol in 16 male patients with coronary heart disease (12 without significant stenosis after percutaneous transluminal coronary angioplasty) at rest, during and after exercise, and before and 80 min after drug application."	5.06	Acute hemodynamic effects of the vasodilating and beta-blocking agent carvedilol in comparison to propranolol. ( Kober, G; Landgraf, H; Schräder, R; van der Does, R; Wendt, T, 1987)
"In 18 patients (17 male and 1 female, 40 to 63 years old) with coronary heart disease, a randomized double-blind study was carried out to investigate in comparison to placebo, the antiischemic effects of 5, 10 and 20 mg isosorbide dinitrate (ISDN) alone and in combination with gallopamil (G: 25 and 50 mg) or 80 mg propranolol (P: 80 mg) on the ischemic ST-segment-depression in standardized exercise ECGs."	5.06	[The anti-ischemic effect of isosorbide dinitrate alone and in combination with gallopamil and propranolol]. ( Hopf, R; Kaltenbach, M; Sthler-Klich, HM, 1989)
"The efficacy and safety of esmolol, an ultra-short-acting beta-adrenergic blocking agent (elimination half-life, 9 min), was investigated in 358 patients with supraventricular tachyarrhythmias (SVTs) in three multicenter studies (placebo-controlled, propranolol-controlled, and open-label baseline-controlled) and in 19 patients with myocardial ischemia (acute myocardial infarction or unstable angina) in a single-center, open-label study."	5.06	Clinical experience with esmolol, a short-acting beta-adrenergic blocker in cardiac arrhythmias and myocardial ischemia. ( Blanski, L; Kirshenbaum, J; Laddu, AR; MacCosbe, P; Sung, RJ; Turlapaty, P, 1986)
"A multicentred, randomised, blind study was started in 1978 to compare propranolol or hyaluronidase with placebo in patients with acute myocardial infarction admitted within 18 hours of onset of symptoms."	5.06	Effect of hyaluronidase on mortality and morbidity in patients with early peaking of plasma creatine kinase MB and non-transmural ischaemia. Multicentre investigation for the limitation of infarct size (MILIS). ( Braunwald, E; Croft, C; Gold, HK; Hartwell, TD; Jaffe, AS; Muller, JE; Mullin, SM; Parker, C; Passamani, ER; Roberts, R, 1988)
"The efficacy and safety of bevantolol (new cardioselective beta-blocking agent without intrinsic sympathetic activity) were evaluated in chronic stable angina pectoris."	5.06	Acute, short- and long-term efficacy of oral bevantolol in patients with coronary artery disease: a placebo-controlled, randomized, double-blind study. ( Algarra, FJ; Bordes, P; Estruch, G; Ferrer, J; Gimeno, JV; Mainer, V; Olague, J; Serra, J, 1986)
"Seventy three patients (63 males and 10 females) aged 41-75 years with established stable exertional angina pectoris were studied in a double-blind fashion to confirm the efficacy of 80 mg propranolol administered three times daily and also to examine its effect on ST-segment changes in the electrocardiogram by ambulatory ST-segment monitoring and exercise testing using on-line computer analysis."	5.06	Effect of propranolol on indices of intermittent myocardial ischemia, assessed by exercise testing and ambulatory ST-segment monitoring. ( Bowles, MJ; Khurmi, NS; O'Hara, MJ; Raftery, EB, 1986)
"The effects of the beta-adrenoceptor-blocking drugs propranolol, metoprolol, pindolol, and placebo, on mucociliary clearance were studied in three groups of 6 subjects with coronary heart disease and normal lung function."	5.05	Influence of propranolol, metoprolol, and pindolol on mucociliary clearance in patients with coronary heart disease. ( Dorow, P; Felix, R; Schiess, W; Schmutzler, H; Weiss, T, 1984)
"The effects of propranolol on lipids and lipoproteins were investigated in survivors of a recent myocardial infarction who were enrolled in the double-blind Beta-Blocker Heart Attack Trial."	5.05	Effects of propranolol on blood lipids and lipoproteins in myocardial infarction. ( Campbell, J; Capone, RJ; Hawkins, CM; Henderson, LO; Herbert, PN; McClure, D; Saritelli, A; Shulman, RS, 1983)
"The bicycle exercise tolerance was studied in ten patients with angina pectoris after one week's treatment with an alpha-beta-blocker (labetalol 300 mg b."	5.05	Relation between ST-depression and chest pain in patients with coronary heart disease receiving no treatment and after beta-blockade and combined alpha-beta-blockade. ( Bjurö, T; Hagman, M; Nyberg, G; Smith, U, 1981)
"The beta-Blocker Heart Attack Trial (BHAT) was a National Heart, Lung, and Blood Institute-sponsored, multicenter, randomized, double-blind, and placebo-controlled trial designed to test whether the regular administration of propranolol hydrochloride to men and women who had experienced at least one myocardial infarction would result in a significant reduction in total mortality during a two- to four-year period."	5.05	A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. ( , 1982)
"Twenty patients with coronary heart disease participated in a double-blind, randomized, crossover study on three study mornings to evaluate the effect of oral oxprenolol 80 mg, oral propranolol 80 mg, and placebo on left ventricular contractility."	5.04	Effects of oxprenolol and propranolol on systolic time intervals. ( Aronow, WS; van Herick, R, 1978)
"Despite widespread clinical application of propranolol (P) in angina pectoris, convincing evidence of its efficacy has been incomplete, thereby resulting in continued controversy."	5.04	Efficacy of beta adrenergic blockade in coronary heart disease: propranolol in angina pectoris. ( Amsterdam, EZ; Mason, DT; Miller, RR; Olson, HG; Pratt, CM, 1975)
" Although nifedipine is highly effective against vasospastic angina, its use in threatened myocardial infarction or severe unstable angina is not supported by recent studies, unless combined with a beta-blocker."	4.77	Calcium channel antagonists. Part II: Use and comparative properties of the three prototypical calcium antagonists in ischemic heart disease, including recommendations based on an analysis of 41 trials. ( Opie, LH, 1988)
" The elevated ST segments of electrocardiogram (ECG), cardiac arrhythmias, and ratio of infarct size/risk zone were compared among the normal control (NC), ischemia and reperfusion (IR), electro-acupuncture (EA), electro-acupuncture plus propranolol (EAP), and EA at nonacupoint (EAN) groups."	3.73	A preliminary study on the cardioprotection of acupuncture pretreatment in rats with ischemia and reperfusion: involvement of cardiac beta-adrenoceptors. ( Fu, W; Gao, J; Jin, Z; Yu, X, 2006)
"The effects of SMP-300, an orally active, potent, and selective Na+/H+ exchange inhibitor, were evaluated and compared with those of nifedipine, propranolol, and nicorandil on three experimental angina models and on myocardial infarction in rats."	3.71	Effect of an orally active Na+/H+ exchange inhibitor, SMP-300, on experimental angina and myocardial infarction models in rats. ( Matsui, K; Ohashi, N; Sasabe, M; Yamamoto, S, 2002)
"Although carvedilol attenuates left ventricular (LV) remodeling in coronary occlusion-reperfusion, it is not known whether it attenuates ischemic LV remodeling because of coronary stenosis (CS) or permanent coronary occlusion (CO)."	3.71	Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats. ( Maehara, K; Maruyama, Y; Sakabe, A; Yaoita, H, 2002)
"The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity."	3.68	Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats. ( Braquet, C; Köpernik, W; Mest, HJ; Rein, T; Riedel, A, 1992)
"Automatic arrhythmias induced by alpha 1-adrenergic stimulation during simulated ischemia may be attributed to a specific alpha 1-adrenergic receptor subtype that is blocked by WB 4101."	3.68	Abnormal automatic rhythms in ischemic Purkinje fibers are modulated by a specific alpha 1-adrenergic receptor subtype. ( Anyukhovsky, EP; Rosen, MR, 1991)
"The effect of adding propranolol to procainamide, quinidine, propafenone or disopyramide was prospectively evaluated in 37 patients, all with prior infarction and inducible ventricular tachycardia (VT)."	3.68	Effectiveness of propranolol added to a type I antiarrhythmic agent for sustained ventricular tachycardia secondary to coronary artery disease. ( Friehling, TD; Kowey, PR; Lipshutz, H; Marinchak, RA; Stohler, JL, 1990)
"The effects of betaxolol, a cardioselective beta-adrenoceptor antagonist, on ischemic myocardial acidosis were studied in dog hearts, in which the left anterior descending coronary artery was partially occluded for 90 min, and were compared with those of atenolol and propranolol."	3.68	Betaxolol, a cardioselective beta-adrenoceptor antagonist, attenuates ischemic myocardial acidosis in dogs. ( Abe, Y; Narimatsu, A; Tobe, A, 1990)
"The relationship between the effect of propranolol treatment on oxygen consumption during exercise and the activity of the sympathoadrenal system (SAS) and the initial hemodynamic circulatory type was established in patients with coronary heart disease (CHD)."	3.67	[Effect of obzidan on the indices of gas exchange and the sympathetic-adrenal system in ischemic heart disease patients with different types of circulation]. ( Katsenovich, RA; Kostko, SZ; Kozhinskiĭ, VM; Kuchenkova, MA, 1984)
"The antiarrhythmic activity of the calcium entry blockers, verapamil, nifedipine and prenylamine, was assessed against arrhythmias occurring during 20 min of acute occlusion, or upon rapid reperfusion of the left anterior descending coronary artery (LAD) in anesthetized pigs."	3.67	Acute coronary artery occlusion-reperfusion arrhythmias in pigs: antiarrhythmic and antifibrillatory evaluation of verapamil, nifedipine, prenylamine and propranolol. ( Bergey, JL; McCallum, JD; Nocella, K; Wendt, RL, 1984)
"To determine the effect of strong analgesics on electrical instability (vulnerability to ventricular fibrillation), we examined the action of fentanyl (60 micrograms/kg), sufentanil (10 micrograms/kg) and carfentanil (3 micrograms/kg) on the ventricular fibrillation threshold (VFT) in a dog model of coronary artery occlusion."	3.67	The antifibrillatory effect of fentanyl, sufentanil and carfentanil in the acute phase of local myocardial ischaemia in the dog. ( Fejfar, Z; Hess, L; Vrana, M; Vranova, Z, 1989)
"Altogether 75 patients (males aged 31 to 67 years) with unstable angina pectoris were subjected to transcutaneous pacing to measure the coronary reserve level before and after administration of obsidan (propranolol) in a dose of 40 mg."	3.67	[Evaluation of obzidan efficacy in patients with unstable stenocardia]. ( Gvatua, NA; Malinovskaia, IE; Pliska, AI; SHumakov, VA; Tashchuk, VK, 1989)
"In 59 patients with mild or moderate essential hypertension effects of propranolol and hydrochlorothiazide on serum lipids, fibrynogen, glucose and uric acid concentrations as well as serum euglobulins fibrynolysis time were studied."	3.67	[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension]. ( Karolko, B; Kawecka, M; Lukasik, S; Moszczyńska, J; Witkowska, M, 1989)
"The effect of the beta-blocker propranolol and of bensonal, a barbituric acid derivative stimulating microsomal oxidation of the liver monooxygenase, was evaluated using the model of experimental myocardial infarction (EMI) in the presence of 3-month cholesterol atherosclerosis."	3.67	[Experimental myocardial infarction in atherosclerosis--various methods of pharmacological correction]. ( Irgashev, ShB, 1985)
"Although congestive heart failure has been reported with the combination of a beta blocker and either verapamil or nifedipine, it has not previously been reported for combination therapy that includes diltiazem."	3.67	Combination therapy with diltiazem and propranolol: precipitation of congestive heart failure. ( Egan, T; McIntyre, KM; Parisi, AF; Strauss, WE, 1985)
"The effects of nadolol on experimental arrhythmias were investigated and compared with those of propranolol and alprenolol."	3.67	Anti-arrhythmic effect of nadolol in experimental arrhythmias: comparison with propranolol and alprenolol. ( Hashimoto, H; Nakashima, M; Oguro, K; Sogabe, K; Takiguchi, Y, 1985)
"This study was designed to investigate the relationships of myocardial concentrations of norepinephrine (NE) and cyclic AMP (c-AMP) to the development of ventricular fibrillation (VF) with reference to the effects of a premedication of dibutyryl cyclic AMP (DBC-AMP) and propranolol in dogs with experimental myocardial infarction."	3.66	Myocardial norepinephrine and cyclic amp concentration following myocardial ischemia--relation to ventricular fibrillation and sudden death. ( Ban, M; Kanayama, H; Ogawa, K; Ukai, M, 1983)
"To assess the response of the relationship between systolic blood pressure and end-systolic volume to pharmacologic agents with known cardiac effects, we studied 21 patients with known coronary heart disease by means of gated radionuclide angiograms during the infusion of phenylephrine."	3.66	Radionuclide evaluation of the systolic blood pressure/end-systolic volume relationship: response to pharmacologic agents in patients with coronary artery disease. ( Costello, D; Slutsky, R; Watkins, J, 1983)
"Propranolol is an effective drug for patients with angina and has been shown to favorably alter exercise ejection fraction and myocardial perfusion images in patients with coronary disease."	3.66	Thallium-201 myocardial imaging during maximal and submaximal exercise: comparison of submaximal exercise with propranolol. ( Kirch, D; Rhodes, CA; Sklar, J; Steele, P; Vogel, R, 1983)
"The effects of medium-dose (160 mg/day) and high-dose (480 mg/day) oral propranolol were compared in 22 patients who had typical angina pectoris and objective evidence of myocardial ischemia during exercise."	3.66	Comparison of high-dose and medium-dose propranolol in the relief of exercise-induced myocardial ischemia. ( Cobb, FR; Coleman, RE; Higginbotham, MB; Morris, KG; Shand, DG, 1983)
"Maximal exercise testing of middle-aged men with either risk factors or prior clinical manifestations of coronary heart disease (CHD), identifies subsets at increased risk for primary or secondary CHD events, aids selection of patients of coronary artery bypass surgery and reveals a subgroup at greater risk if treated with propranolol."	3.66	Predictive value of symptom-limited exercise for risk assessment of primary and secondary events due to coronary heart disease in men. ( Bruce, RA; DeRouen, TA; Hossack, KF, 1981)
" We administered 40-, 80- and 120-mg doses of verapamil orally to 15 patients with angina pectoris who were receiving high doses of propranolol or metoprolol."	3.66	Hemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man. ( Gorlin, R; Guererro, J; Holt, J; McAllister, RG; Medina, N; Meller, J; Packer, M; Smith, H; Todd, GD; Yushak, M, 1982)
"The disposition of the pharmacologically active 4-hydroxypropranolol (HO-P), its glucuronic acid conjugate (HO-P-G), and propranolol were compared after single intravenous and oral doses of propranolol in 6 normal subjects and after long-term therapy in 32 patients with hypertension or coronary artery disease."	3.66	4-Hydroxypropranolol and its glucuronide after single and long-term doses of propranolol. ( Conradi, EC; Fagan, TC; Gaffney, TE; Walle, T; Walle, UK, 1980)
"Review of a longitudinal study of the effects of 40 mg of propranolol orally in 14 patients with coronary heart disease demonstrated a minor but not statistically significant change in the relationship of percentage of maximal oxygen uptake to percentage of maximal heart rate."	3.66	Influence of propranolol on exercise prescription of training heart rates. ( Bruce, RA; Clarke, LJ; Hossack, KF, 1980)
" Propranolol inhibited the increases in cyclic AMP and reduced the frequency of PVCs in animals without ventricular fibrillation."	3.66	Mechanisms contributing to malignant dysrhythmias induced by ischemia in the cat. ( Corr, PB; Sobel, BE; Witkowski, FX, 1978)
"A regimen consisting of chlorthalidone, hydralazine and propranolol would be useful in some hypertensive patients with coronary artery disease or aortic dissection if it could be shown that reflex cardiac stimulation induced by hydralazine is completely neutralized by propranolol."	3.66	Echocardiographic assessment of the effect of an antihypertensive regimen on left ventricular performance. ( Belasco, RN; Moyer, JP; Pittman, AW; Woods, JW, 1979)
"Nifedipine was evaluated in the management of eight patients with intractable coronary arterial spasm."	3.66	Nifedipine therapy for refractory coronary arterial spasm. ( Heupler, FA; Proudfit, WL, 1979)
" Significantly augmented non-uniform flow changes, however, were produced by ganglion stimulation during hypertension caused by aortic constriction or by methoxamine."	3.65	Non-uniform myocardial blood flow caused by stellate ganglion stimulation. ( Uchida, Y; Ueda, H, 1975)
"On 51 of 53 occasions, sudden withdrawal of propranolol from patients with angina pectoris produced no substantial adverse effects."	3.65	Sudden withdrawal of propranolol in patients with angina pectoris. ( Myers, MG; Wisenberg, G, 1977)
"50 patients with stenocardias in persisting arterial hypertension, of them 33 manifest coronary diseases, were orally treated with doses of propranolol up to 400 mg/die during a longer period."	3.65	[Therapy of chronic ischemic heart disease and arterial hypertension by means of beta-receptor blockaders]. ( Dück, K; Knappe, J; Strube, G, 1976)
"The records of 185 consecutive patients having myocardial revascularization were reviewed with regard to preoperative administration of propranolol and intraoperative or postoperative complications."	3.65	Propranolol therapy in patients undergoing myocardial revascularization. ( Dorney, ER; Douglas, JS; Hatcher, CR; Jones, EL; Kaplan, JA; King, SB, 1976)
"Clinical and hemodynamic benefits have been documented after giving diazepam to patients with coronary heart disease."	3.65	Systemic vasodilatation following diazepam after combined sympathetic and parasympathetic blockade in patients with coronary heart disease. ( Bourassa, MG; Côté, P; Noble, J, 1976)
"The effects of intravenous propranolol on left ventricular wall motion and hemodynamics were studied in 16 patients, 12 with significant coronary artery disease and four with chest pain but no coronary disease."	3.65	Left ventricular wall motion response to intravenous propranolol. ( Dinsmore, RE; Harthorne, JW; Shubrooks, SJ; Zir, LM, 1975)
" Studies were also performed in dogs that were (1) pretreated with propranolol, (2) subjected to ventricular fibrillation, and (3) volume loaded."	3.65	Transmural gradients in ventricular tissue metabolites produced by stopping coronary blood flow in the dog. ( Dunn, RB; Griggs, DM, 1975)
"The data from this study document that dobutamine is a powerful inotropic agent in anesthetized dogs with acute myocardial ischemia and in awake, unsedated ones with chronic myocardial infarction."	3.65	Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs. ( Hutton, I; Platt, MR; Templeton, GH; Watson, JT; Willerson, JT, 1976)
"Carvedilol is a multiple-action cardiovascular agent that is both a beta-adrenoceptor antagonist and a vasodilator and has recently been made available for the treatment of mild-to-moderate hypertension."	2.67	Myocardial protection with carvedilol. ( Bril, A; Feuerstein, GZ; Hamburger, SA; Ruffolo, RR; Smith, EF, 1992)
"Hydrochlorothiazide was used alone in 36 percent of patients, in combination with propranolol in 26 percent, and with methyldopa in 20 percent."	2.66	Coronary heart disease and treatment of hypertension. Some Oslo Study data. ( Helgeland, A; Leren, P, 1986)
"with complicated infarctions or complex arrhythmias."	2.66	The Beta-blocker Heart Attack Trial. ( Furberg, CD, 1985)
"Treatment with propranolol in non-smoking men in the highest age and blood pressure categories would lead to a reduction in the number having strokes from three to one or two and might possibly reduce the number experiencing myocardial infarction from seven to four."	2.66	Stroke and coronary heart disease in mild hypertension: risk factors and the value of treatment. Medical Research Council Working Party. ( , 1988)
"A new cardioselective betablocker, celiprolol (C) in a dosage of 100 mg t."	2.65	[Double-blind, placebo-controlled trial of propranolol vs celiprolol in stable effort angina: antianginal efficacy and side effects ]. ( Brandt, D; Fluch, N; Klein, W, 1982)
"To test the hypothesis that the depression of cardiac performance induced by competitive blockade of sympathetic stimulation at beta-adrenoceptors could be attenuated by the addition of a high level of intrinsic sympathomimetic activity (ISA) or concomitant alpha- and beta-blockade, the haemodynamic dose-response effects of propranolol (non-cardioselective, no ISA), pindolol (non-cardioselective, high ISA) and labetalol (non-cardioselective, alpha-blocker) were compared in a randomized study of 30 patients with stable coronary artery disease."	2.65	Beta-blockade in ischaemic heart disease--influence of concomitant ISA or alpha-blockade on haemodynamic profile. ( Ahuja, RC; Nelson, GI; Silke, B; Taylor, SH, 1983)
"Acebutolol is a new investigational beta-antagonist which has intrinsic sympathomimetic and cardioselective properties."	2.65	Comparative effects of oral acebutolol and propranolol at rest and during exercise in ischemic heart disease: double-blind placebo crossover study utilizing radionuclide ventriculography. ( Hecht, HS; Hopkins, J; Kaul, S; Seidman, R; Singh, BN, 1984)
"To determine whether the depression of left ventricular pumping activity associated with beta-blockade alone could be offset by a substantial degree of partial agonist activity, the haemodynamic dose-response effects of intravenous propranolol and pindolol were compared in a randomised between-group saline controlled study in twenty patients with angiographically proven coronary artery disease."	2.65	Comparative haemodynamic dose-response effects of intravenous propranolol and pindolol in patients with coronary heart disease. ( Ahuja, RC; Nelson, GI; Okoli, RC; Silke, B; Taylor, SH, 1983)
"Labetalol was followed by significant dose related decreases in systemic blood pressure and vascular resistance associated with a significant increase in cardiac output; heart rate and pulmonary artery occluded pressure were unchanged."	2.65	Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease. ( Ahuja, RC; Nelson, GI; Silke, B; Taylor, SH, 1982)
"Propranolol and practolol were tested in patients with repeated daily occurrence of spontaneous angina."	2.64	Treatment of spontaneous angina pectoris with beta blocking agents. A clinical, electrocardiographic, and haemodynamic appraisal. ( Fiorentini, C; Guazzi, M; Magrini, F; Olivari, MT; Polese, A, 1975)
"Hypertension is an important risk factor for adverse cardiovascular events including stroke, myocardial infarction, heart failure and renal failure."	2.55	Pharmacotherapy for hypertension in adults aged 18 to 59 years. ( Gueyffier, F; Musini, VM; Puil, L; Salzwedel, DM; Wright, JM, 2017)
"Type 2 diabetes is becoming very common and is closely linked to physical inactivity and obesity."	2.41	Beta-blockers and diabetes: the bad guys come good. ( Cruickshank, JM, 2002)
"Most studies of the timing of onset of sudden cardiac death have revealed a prominent midmorning peak, thought to be related to a surge in catecholamines associated with arising and assuming the upright posture, that is blunted or eliminated by beta blockers."	2.39	Circadian patterns and triggers of sudden cardiac death. ( Peters, RW, 1996)
"In the patient with cardiac arrest related to transient myocardial ischemia, a direct approach toward relieving ischemia seems appropriate."	2.37	Considerations in the long-term management of survivors of cardiac arrest. ( Cobb, LA; Greene, HL; Hallstrom, AP; Trobaugh, GB; Weaver, WD, 1984)
"Unstable angina is a common ischemic syndrome that is characterized by chest pain occurring at rest often with transient ischemic electrocardiographic changes."	2.37	Assessing the total ischemic burden in the management of unstable angina. A review. ( Gerstenblith, G; Gottlieb, SO, 1986)
" Medical treatment should be considered a failure only if maximal dosage of nitrates and beta blockers is attained without satisfactory control of symptoms."	2.36	What is optimal drug therapy in angina pectoris? ( Brest, AN; Frankl, WS, 1983)
"The BO-induced atrial remodeling was associated with increased calmodulin kinase II-mediated ryanodine receptor 2 phosphorylation on serine 2814, as well as inhibition of Akt phosphorylation."	1.56	Effects of occlusal disharmony on susceptibility to atrial fibrillation in mice. ( Hayakawa, Y; Ito, A; Matsuo, I; Mototani, Y; Nariyama, M; Ohnuki, Y; Okumura, S; Saeki, Y; Suita, K; Umeki, D; Yagisawa, Y, 2020)
" A prolongation of propranolol biological half-life from 5."	1.35	Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol. ( Auler, JO; Carmona, MJ; Malbouisson, LM; Pereira, VA; Santos, SR, 2009)
" Pharmacokinetic Solutions 2."	1.33	Cardiopulmonary bypass alters the pharmacokinetics of propranolol in patients undergoing cardiac surgery. ( Auler, JO; Bertoline, MA; Carmona, MJ; Le Bihan, KB; Malbouisson, LM; Omosako, CE; Pereira, VA; Santos, SR, 2005)
"Propranolol has no observable effect on coronary collateral development despite its acknowledged ability to prevent or attenuate myocardial ischaemia."	1.29	Lack of effect of propranolol on canine coronary collateral development during progressive coronary stenosis and occlusion. ( Cohen, MV, 1993)
"4."	1.28	Impaired endothelium-dependent relaxation of dog coronary arteries after myocardial ischaemia and reperfusion: prevention by amlodipine, propranolol and allopurinol. ( Dalipram, RA; Dusting, GJ; Sobey, CG; Woodman, OL, 1992)
"Treatment with propranolol alone did not affect the outcome."	1.28	Control of ventricular fibrillation after coronary artery occlusion via intracerebroventricular injections. ( Johnson, DA; Kirby, DA; Lown, B; Pinto, J; Zhao, S, 1992)
"Propranolol was withdrawn 3 days before flow and function determinations and was resumed immediately after testing."	1.28	Chronic reduction of myocardial ischemia does not attenuate coronary collateral development in miniswine. ( Longhurst, JC; Pitsillides, KF; Symons, JD, 1992)
"Both propranolol and verapamil were slightly more active than carvedilol in inhibiting epinephrine-induced platelet aggregation, a trend consistent with the IC50 values."	1.28	Comparison of the effects of carvedilol, propranolol, and verapamil on in vitro platelet function in healthy volunteers. ( Betterridge, DJ; Gasser, JA, 1991)
"Propranolol was administered intravenously and then measurements were made during imposition of a stenosis on the perfusion circuit sufficient to decrease systolic shortening by 30%."	1.28	Nitrous oxide does not worsen myocardial ischaemia following beta-receptor blockade in isoflurane anaesthetized dogs. ( Nathan, HJ, 1991)
"Propranolol is a well-known powerful betareceptor-blocking agent."	1.28	[Synthesis and pharmacologic properties of pranolium and its optical isomers]. ( Flöther, FU; Foken, H; Gerbsch, S; Gröger, D; Grünheid, K; Hagen, A; Heyde, R; Lohmann, D; Schmauder, HP, 1990)
"Propranolol was administered in two equally divided doses 30 min before and 10 min after ligation of the anterior descending coronary artery (CAL) in anesthetized open-chest pigs."	1.28	Critical role of dose in protection by propranolol against ventricular fibrillation in a pig model of acute myocardial ischemia. ( Hamm, CW; Muller, CA; Opie, LH; Peisach, M; Pineda, CA; Thandroyen, FT, 1989)
"Chronic treatment of heart failure patients with beta-adrenoceptor antagonists leads to an up-regulation of cardiac beta-adrenoceptors, but in a subtype-selective fashion: beta 1-selective antagonists increase only cardiac beta 1-adrenoceptors, whereas non-selective antagonists increase both beta 1- and beta 2-adrenoceptors."	1.28	Drug- and disease-induced changes of human cardiac beta 1- and beta 2-adrenoceptors. ( Borst, HG; Brodde, OE; Maier, W; Michel, MC; Zerkowski, HR, 1989)
"Propranolol was infused into the bypass tube to exclude the metabolic effects of norepinephrine."	1.28	Beneficial effects of alpha 2-adrenoceptor activity on ischemic myocardium during coronary hypoperfusion in dogs. ( Gotoh, K; Hori, M; Inoue, M; Iwakura, K; Kamada, T; Kitabatake, A; Kitakaze, M; Sato, H, 1989)
"Isradipine is a new dihydropyridine calcium antagonist with myocardial effects significantly different from those of nifedipine, as shown by in vitro and animal experimental data."	1.28	Myocardial properties of the new dihydropyridine calcium antagonist isradipine compared to nifedipine with or without additional beta blockade in coronary artery disease. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1989)
" Atenolol, ICI 111,581 and propranolol were given at low, medium and high doses calculated to shift dose-response curves to exogenous agonists by factors of 10-30, 100-300 and 1000-3000, respectively."	1.28	Mechanisms underlying the antiarrhythmic properties of beta-adrenoceptor blockade against ischaemia-induced arrhythmias in acutely prepared rats. ( Abraham, S; Beatch, GN; Paletta, MJ; Walker, MJ, 1989)
"Propranolol-pretreated dogs (N = 9) displayed a significantly lower left ventricular peak-positive rise in ventricular pressure (dP/dt), heart rate, and rate-pressure product throughout the experiment compared with the control group (N = 15)."	1.28	Improvement in functional recovery of stunned canine myocardium by long-term pretreatment with oral propranolol. ( al-Wathiqui, MH; Brooks, HL; Farber, N; Gross, GJ; Pelc, L; Warltier, DC, 1989)
"Nifedipine is a strong calcium antagonist; it blocks the excitation-contraction coupling, yet at therapeutic dosage levels it has few side effects."	1.27	What is preferable in unstable angina, beta-blockade or calcium-inhibition? ( Hugenholtz, PG; Serruys, PW; Simoons, ML, 1983)
"In phentolamine-treated dogs, arterial pressure and heart rate were kept constant to prevent exacerbation of ischemia."	1.27	Effect of alpha-adrenergic blockade on arrhythmias induced by acute myocardial ischemia and reperfusion in the dog. ( Bolli, R; Fisher, DJ; Miller, RR; Taylor, AA; Young, JB, 1984)
"When propranolol was given during ischaemia and reperfusion, ATP degradation during the ischaemic period was reduced and adenosine uptake was strongly stimulated on reperfusion (+60%)."	1.27	[Acceleration of the synthesis of cardiac adenine nucleotides from adenosine as affected by propranolol]. ( Aussedat, J; Giacomelli, M; Lavanchy, N; Rossi, A, 1984)
"Arrhythmias were significantly more frequent during low flow (10% of control) than zero flow ischaemia and were most frequent during reperfusion following 30 minute ischaemia."	1.27	The deleterious effects of myocardial catecholamines on cellular electrophysiology and arrhythmias during ischaemia and reperfusion. ( Penny, WJ, 1984)
"nicardipine was given to 9 patients with coronary artery disease, pretreated with propranolol (0."	1.27	Effects of nicardipine or nifedipine added to propranolol in patients with coronary artery disease. ( Brasseur, LA; Charlier, AA; Etienne, J; Pouleur, H; Rousseau, MF; Van Eyll, C; Van Mechelen, H, 1984)
"The number of reperfusion arrhythmias was also significantly lower in the treated animals."	1.27	Nifedipine with and without propranolol in the treatment of myocardial ischemia: effect on ventricular arrhythmias and recovery of regional wall function. ( ten Cate, FJ; Verdouw, PD; Wolffenbuttel, BH, 1983)
"Propranolol use was significantly higher in patients with abnormal than in those with normal thallium lung/heart ratios (p less than 0."	1.27	Radionuclide-determined changes in pulmonary blood volume and thallium lung uptake in patients with coronary artery disease. ( Boucher, CA; Okada, RD; Pohost, GM; Strauss, HW; Wilson, RA, 1983)
"Propranolol has a small depressant effect on global and segmental left ventricular function in patients with coronary artery disease."	1.27	Effects of propranolol on resting and postextrasystolic potentiated left ventricular function in patients with coronary artery disease. ( Friedman, MJ; Goldman, S; Ovitt, TW; Temkin, LP, 1983)
"Pretreatment with propranolol diminished the number of VA generated in the 1b phase but not those in the 1a phase; however, these differences were statistically not significant."	1.27	Effect of propranolol on early postischemia arrhythmias and noradrenaline and potassium release of ischemic myocardium in anesthetized pigs. ( Addicks, K; Bischoff, A; Hirche, H; Knopf, H; McDonald, FM, 1988)
"A distinct phase of ventricular arrhythmias was evident about 10 to 30 min after ligation."	1.27	Prevention of ventricular fibrillation by metoprolol in a pig model of acute myocardial ischaemia: absence of a major arrhythmogenic role for cyclic AMP. ( Gihwala, D; Hamm, CW; Muller, CA; Opie, LH; Peisach, M, 1986)
"Propranolol treatment led to an externalization of beta-receptors from light vesicle to sarcolemmal fractions."	1.27	Propranolol treatment externalizes beta-adrenergic receptors in guinea pig myocardium and prevents further externalization by ischemia. ( Insel, PA; Maisel, AS; Motulsky, HJ, 1987)
"Propranolol treatment limited progressive death of myocardial cell population, reducing by 37% myocardial infarction size by day 7 of the experimental study, as compared to the situation in the untreated animals."	1.27	[Effect of the beta-blocker propranolol (obzidan) on the content of macroergic phosphates and the development of the size of necrotic areas in the myocardium in experimental acute coronary occlusion]. ( Irgashev, ShB; Iuldashev, NM; Mavridi, DI, 1988)
"Pretreatment with propranolol (1 mg/kg) inhibited almost completely the accumulation of NEFA induced by occlusion of the LAD, whereas pretreatment with d-propranolol (1 mg/kg) did not inhibit the accumulation of NEFA, although it tended to inhibit the accumulation of palmitoleic, stearic and arachidonic acids."	1.27	Propranolol inhibits accumulation of non-esterified fatty acids in the ischemic dog heart. ( Abiko, Y; Hashizume, H; Miura, I, 1988)
"These arrhythmias have responded to sympathetic blocking agents, which may also have a protective effect on subendocardial tissue in this setting."	1.27	Subarachnoid hemorrhage and the heart. ( Marion, DW; Segal, R; Thompson, ME, 1986)
"Propranolol treatment for 6, 12 and 24 months was associated with a pronounced antianginal effect, both subjective and objective, in coronary patients, while the side effects rate was relatively small (3."	1.27	[Functional status of the myocardium of ischemic heart disease patients during long-term treatment with beta blockers]. ( Dorogoĭ, AP; Furkalo, NK; Zaĭtseva, VI, 1987)
" Socially dominant animals had (as in previous studies) significantly exacerbated CAA, but only in the untreated segment; the effect of social dominance on CAA was abolished by long-term administration of propranolol."	1.27	Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. ( Adams, MR; Clarkson, TB; Kaplan, JR; Manuck, SB; Weingand, KW, 1987)
"Malignant ventricular arrhythmias appearing during acute myocardial ischaemia, are the most frequent mechanism of sudden death."	1.27	Ventricular arrhythmias during acute myocardial ischaemia in man. The role and significance of R-ST-T alternans and the prevention of ischaemic sudden death by medical treatment. ( Campana, C; Chimienti, M; Falcone, C; Guasti, L; Klersy, C; Marangoni, E; Panciroli, C; Previtali, M; Regazzi Bonora, M; Salerno, JA, 1986)
"Propranolol was then added by intravenous bolus (0."	1.27	Diltiazem and propranolol in combination: hemodynamic effects following acute intravenous administration. ( Alderman, EL; Baim, DS; Beier-Scott, L; Oesterle, SN; Rothman, MT; Schroeder, JS, 1986)
"Protection from arrhythmias seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation."	1.27	The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. ( Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G, 1985)
" The dose-response effectiveness for the prototype antiarrhythmic drugs, propranolol, quinidine and lidocaine in converting the induced ventricular fibrillation to sinus rhythm was determined."	1.27	A cardiac antiarrhythmic screening test using the isolated ischaemic perfused rat heart preparation. ( Lee, AY; Mok, CP; Wong, TM; Zhan, CY, 1985)
"Resistance across the stenosis decreased significantly (p less than 0."	1.26	Changes in ischemic blood flow distribution and dynamic severity of a coronary stenosis induced by beta blockade in the canine heart. ( Buck, JD; Gross, GJ; Hardman, HF; Warltier, DC, 1981)
"Carazolol was active at considerably lower doses than pindolol (about 25 times less) and propranolol (about 100 times later)."	1.26	Comparative investigation on the cardio-protective action of the beta-blockers carazolol, propranolol and pindolol in rats. ( Bartsch, W; Dietmann, K; Kohler, M; Sponer, G, 1981)
"In 33 patients, premature beats were also introduced 330 msec beyond the RV refractory period to compare effects of long and short compensatory pauses on frequency of postextrasystolic T wave alterations."	1.26	Evaluation of postextrasystolic T wave alterations in identification of patients with coronary artery disease or left ventricular dysfunction. ( Dehmer, GJ; Firth, BG; Hillis, LD; Leachman, DR; Markham, RV; Winniford, MD, 1981)
"d-Propranolol did not inhibit the heart rate response but inhibited the blood lactate response to isoproterenol significantly."	1.26	Increase of myocardial pH by 1- and d-propranolol during ischemia of the heart in dogs. ( Abiko, Y; Sakai, K, 1980)
"In propranolol-treated animals, the concentration of cyclic GMP in both infarcted and noninfarcted area increased significantly compared with control at 15 min and 60 min."	1.26	Effect of propranolol on cyclic nucleotides of ischemic dog heart. ( Nakamura, T; Ogawa, K, 1980)
"Coronary spasm is due to strong contraction of coronary vascular smooth muscle cells which is triggered by an increase of intracellular calcium ions; hyperventilation plus TRIS-buffer infusion induces coronary spasm by decreasing hydrogen ions which antagonize the action of calcium ions."	1.26	Pathophysiology and treatment of coronary arterial spasm. ( Yasue, H, 1980)
" In contrast, mannitol, isosorbide dinitrate, and propranolol, each combined with IABP support, produced significant improvements in collateral flow within the same time periods."	1.26	Intraaortic balloon counterpulsation: its influence alone and combined with various pharmacological agents on regional myocardial blood flow during experimental acute coronary occlusion. ( Barnett, PA; Dengle, SK; Eberhart, RC; Jett, GK; Platt, MR; Watson, JT; Willerson, JT, 1981)
"Propranolol treatment in vivo (2 mg/kg) and/or in vitro (0."	1.26	Abnormalities of volume regulation and membrane integrity in myocardial tissue slices after early ischemic injury in the dog: effects of mannitol, polyethylene glycol, and propranolol. ( Buja, LM; Willerson, JT, 1981)
"Twelve patients with mitral valve prolapse in whom exercise testing was positive underwent a repeat study after beta blockade."	1.26	Exercise testing in mitral valve prolapse before and after beta blockade. ( Abinader, EG; Shahar, J, 1982)
" The combination was given in a dosage that produced values for systemic blood pressure, heart rate, and maximal positive left-ventricular dP/dt (LV dP/dt) that were similar to those produced by halothane."	1.26	Treatment of myocardial ischemia with halothane or nitroprusside-propranolol. ( Bainton, CR; Gerson, JI; Hickey, RF, 1982)
"Thus nifedipine appears to be an efficacious agent in the treatment of refractory rest angina in patients with obstructive coronary artery disease."	1.26	Efficacy of nifedipine in rest angina refractory to propranolol and nitrates in patients with obstructive coronary artery disease. ( Banka, VS; Bodenheimer, MM; Feldman, M; Helfant, RH; Moses, JW; Wertheimer, JH, 1981)
"Pre-treatment with propranolol appears to exert a protective effect on the myocardium even during reversible ischaemia."	1.26	Myocardial and peripheral catecholamine responses to acute coronary artery constriction before and after propranolol treatment in the anaesthetised dog. ( Leversha, L; Lim, SP; McGrath, BP; Shanahan, A, 1981)
"The hypotensive effect of nifedipine (a Ca2+-antagonist) was studied in acute tests and during the long-term administration of the drug together with propranolol."	1.26	Hypotensive action of nifedipine (Ca2+-antagonist) and propranolol in acute trials and its long-term therapy of hypertensive coronary heart disease patients. ( Aoki, K; Kato, K; Kawaguchi, Y; Kondo, S; Mochizuki, A; Sato, K; Yamamoto, M, 1981)
"81mKrypton was used to study regional myocardial perfusion, and myocardial metabolism was assessed using the epicardial ECG and release of creatine kinase activity (CK)."	1.26	The effects of propranolol on myocardial perfusion and metabolism during acute regional ischaemia. ( Fox, KM; Selwyn, AP; Welman, E, 1980)
" In patients as well as in normal subjects, the data indicated considerable beta-blocking effects for both drugs at the end of a 12-hourly dosing schedule, suggesting that twice-daily timolol and propranolol may be clinically practical."	1.26	Plasma timolol levels and systolic time intervals. ( Chew, C; Collett, J; Singh, BN; Whitlock, RM; Williams, FM, 1980)
"Pretreatment with diazepam reversed both responses of the coronary group."	1.26	Response time and heart rate in coronary patients under mild mental stress. ( Moulopoulos, SD; Nanas, JN; Sideris, DA; Thomakos, S, 1980)
" There is increasing evidence that certain orally administered nitrates at larger than usual dosage can further increase the tolerance to effort."	1.26	Pharmacotherapy of myocardial ischemia. ( Gorlin, R, 1976)
"The effect is critically reviewed of chronic administration of beta-adrenoreceptor antagonists on morbidity and mortality in angina pectoris and myocardial infarction."	1.26	The effect of beta-adrenoreceptive antagonists on the morbidity and mortality in cardiovascular disease. ( Fitzgerald, JD, 1976)
"The patient appears to have dystrophia myotonica which had not been evident before propranolol therapy."	1.26	Myotonia precipitated by propranolol therapy. ( Blessing, W; Walsh, JC, 1977)
"Nitroglycerin can increase blood flow to the underperfused endocardium in the absence of alterations in heart size, hemodynamic parameters, and total transmural flow to the ischemic region."	1.26	Effects of nitroglycerin and propranolol on the distribution of transmural myocardial blood flow during ischemia in the absence of hemodynamic changes in the unanesthetized dog. ( Greenfield, JC; McHale, PA; Parker, JP; Swain, JL, 1979)
"Propranolol (0."	1.26	The protective effect of propranolol on ischemic myocardium: an electron microscopic study. ( Hahano, R; Sunaga, T; Yamamoto, N, 1977)
"Treatment with propranolol was not attended with signs of cardiac insufficiency or aggravation of its subclinical symptoms."	1.26	[Myocardial function and the use of propranolol in ischemic heart disease]. ( Kasatkina, LV; Lupanov, VP; Mazaev, VP; Sidorenko, BA, 1979)
"Propranolol was marketed for clinical use as 'Inderal' by the Pharmaceuticals Division of Imperial Chemical Industries, UK, where this original work had been done."	1.26	Protection from morbidity and mortality from first infarcts: the case for beta-blockade. ( Lambert, DM, 1978)
"Systolic hypertension is difficult to control in the elderly, but this is not an excuse for denying these patients the benefits of carefully controlled antihypertensive treatment, particularly when target organ disease is present."	1.26	Should you treat systolic hypertension in elderly patients? ( Tarazi, RC, 1978)
" When keeping the heart rate constant by means of a pace maker, carbocromen even at higher dosage caused a clear-cut improvement."	1.26	[The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)]. ( Kunath, B; Nitz, RE; Scholtholt, J; Sirbulescu, R, 1976)
"Myocardial infarction was produced by occlusion of the left circumflex coronary artery for 60 minutes followed by reperfusion and quantitation of infarct volume 24 hours later."	1.26	Ischemic changes in the canine heart as affected by the dimethyl quaternary analog of propranolol, UM-272 (SC-27761). ( Abrams, GD; Burmeister, WE; Lomas, TE; Lucchesi, BR, 1976)
"Propranolol has been shown to reduce the extent of necrosis that develops after temporary coronary occlusion in dogs."	1.26	On the nature of protection by propranolol against myocardial necrosis after temporary coronary occlusion in dogs. ( Jennings, RB; Rasmussen, MM; Reimer, KA, 1976)
"Propranolol has been shown to improve bioenergetics and reduce anaerobic glycolysis by a depression of the hemodynamic response of ischemic myocardium."	1.26	Metabolic evaluation of agents designed to protect the ischemic myocardium and to reduce infarct size. ( Brachfeld, N, 1976)
"The propranolol-test was inaugurated as a simple method for the differentiation, whether repolarisation disturbance in the ECG is based on an organic or a functional cause."	1.25	[Value of the propranolol test in the differential diagnosis of repolarization disorders in the ECG]. ( Paris, VV; Schwela, H, 1975)
"In 6 patients with atrial septal defect, propranolol was without effect."	1.25	Assessment of proximal tubular sodium reabsorption during water diuresis in patients with heart disease. ( Gibson, DG; Lockey, E; Marshall, JC, 1970)
"The toxic effects associated with rapid lipid mobilization and a high plasma free fatty acid (FFA) concentration produced by glucagon were evaluated."	1.25	Toxic effects of glucagon-induced acute lipid mobilization in geese. ( Connor, WE; Hoak, JC; Warner, ED, 1968)

Research

Studies (1,083)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Incidence of Mortality

Timeframe	Studies, this research(%)	All Research%
pre-1990	982 (90.67)	18.7374
1990's	87 (8.03)	18.2507
2000's	10 (0.92)	29.6817
2010's	3 (0.28)	24.3611
2020's	1 (0.09)	2.80

Authors	Studies
Suita, K	1
Yagisawa, Y	1
Ohnuki, Y	1
Umeki, D	1
Nariyama, M	1
Ito, A	1
Hayakawa, Y	1
Matsuo, I	1
Mototani, Y	1
Saeki, Y	1
Okumura, S	1
Zhang, Y	1
Sun, N	1
Jiang, X	1
Xi, Y	1
Musini, VM	1
Gueyffier, F	1
Puil, L	1
Salzwedel, DM	1
Wright, JM	1
Carmona, MJ	2
Pereira, VA	2
Malbouisson, LM	2
Auler, JO	2
Santos, SR	2
Cruickshank, JM	1
ROWLANDS, DJ	1
HOWITT, G	1
MARKMAN, P	1
Shim, SS	1
Kim, Y	1
Lim, SM	1
Bertoline, MA	1
Omosako, CE	1
Le Bihan, KB	1
Gao, J	1
Fu, W	1
Jin, Z	1
Yu, X	1
Renner, C	1
Rouffy, J	1
Benthe, HF	1
Szulc, EJ	1
Johansson, SR	1
McCall, M	1
Wilhelmsson, C	2
Vedin, JA	1
Leren, P	3
Foss, PO	1
Helgeland, A	4
Hjermann, I	1
Holme, I	1
Lund-Larsen, PG	1
Ol'binskaia, LI	4
Bragina, GI	3
Litvitskiĭ, PF	2
Andrieu, JL	1
Lièvre, M	1
Chah, QT	1
Faucon, G	1
Melby, K	1
Bache, RJ	1
Norris, RM	4
Bush, LR	5
Haack, DW	1
Shlafer, M	2
Lucchesi, BR	7
Kotko, DN	1
Fed'ko, GP	1
Iaroshenko, IuT	1
Merker, R	1
Schwittek, W	1
Kladetzky, RG	1
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Buck, JD	3
Hardman, HF	6
Warltier, DC	8
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Ross, J	10
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Barnaby, PF	1
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Meerson, FZ	1
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Klein, W	1
Fluch, N	1
Brandt, D	1
Winniford, MD	4
Hillis, LD	9
Nayler, WG	3
Pchelintsev, VP	1
Filonenko, SP	1
Frankl, WS	1
Brest, AN	1
Green, D	1
Rossi, EC	1
Haring, O	1
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Montorsi, P	2
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Kern, MJ	2
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Fukumoto, T	1
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Davies, RA	1
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Black, HR	1
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Abiko, Y	10
Sakai, K	3
Lindenau, KF	1
Krause, EG	3
Bartel, S	2
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Scholz, PM	1
Upton, MT	1
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Ichihara, K	6
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Strauss, HW	8
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Villers, D	1
Pinaud, ML	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
[NCT00000492]	Phase 3	0 participants	Interventional	1977-09-30	Completed
The PACE-MI Registry Study - Outcomes of Beta-blocker Therapy After Myocardial Infarction (OBTAIN)[NCT00430612]		7,057 participants (Actual)	Observational [Patient Registry]	2009-05-31	Completed
Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery[NCT04421209]	Phase 2	0 participants (Actual)	Interventional	2020-12-31	Withdrawn (stopped due to No funding source)
The Effect of Preoperative Exercise on Postoperative Outcome in AAA Patients: Pilot Study[NCT02845167]		21 participants (Actual)	Interventional	2011-09-30	Completed
[NCT00005144]		0 participants	Observational	1978-08-31	Completed
[NCT00000493]	Phase 3	0 participants	Interventional	1977-09-30	Completed
Phase III Study of Metabolic Intervention With Glutamate in Coronary Surgery II[NCT02592824]	Phase 3	321 participants (Actual)	Interventional	2015-11-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Postoperative mortality was defined as mortality within 30 days of surgery. (NCT02592824)
Timeframe: up to 30 days

Incidence of Unexpected Adverse Events

Intervention	Participants (Count of Participants)
Intravenous Glutamate Infusion	1
Intravenous Saline Infusion	6

suspected unexpected serious adverse reaction (NCT02592824)
Timeframe: within 24 hours from infusion

Number of Participants With Incidence of Stroke

Intervention	Participants (Count of Participants)
Intravenous Glutamate Infusion	0
Intravenous Saline Infusion	0

"Postoperative stroke was defined as neurological or cognitive deficit with a cerebral injury verified on (Computed Tomography) CT-scan. All suspected cases of stroke underwent CT-scan.~Stroke within 24 h of surgery was defined as a stroke that occurred within 24 h of surgery or signs of a stroke, when first assessable in deeply sedated patients on a ventilator." (NCT02592824)
Timeframe: within 24 hours from surgery

Postoperative Increase of Plasma NT-proBNP

Intervention	Participants (Count of Participants)
Intravenous Glutamate Infusion	0
Intravenous Saline Infusion	4

"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~In the first GLUTAMICS trial a good agreement between hemodynamic criteria for postoperative heart failure and postoperative NT-proBNP was found." (NCT02592824)
Timeframe: from the day before surgery to the third postoperative day

Postoperative Increase of Plasma NT-proBNP in Patients Without Diabetes

Intervention	ng/L (Mean)
Intravenous Glutamate Infusion	5390
Intravenous Saline Infusion	6452

"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~Previous observations suggest a blunted effect of glutamate in diabetic hearts." (NCT02592824)
Timeframe: from preoperative level to the third postoperative day

Postoperative Plasma Level of NT-proBNP

Intervention	ng/L (Mean)
Intravenous Glutamate Infusion	4503
Intravenous Saline Infusion	6825

Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: first postoperative day

Postoperative Plasma Level of NT-proBNP

Intervention	ng/L (Mean)
Intravenous Glutamate Infusion	4438
Intravenous Saline Infusion	4420

Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: third postoperative day

Article	Year
Comparative efficacy of β-blockers on mortality and cardiovascular outcomes in patients with hypertension: a systematic review and network meta-analysis. Journal of the American Society of Hypertension : JASH, 2017, Volume: 11, Issue:7 Topics: Adrenergic beta-Antagonists; Age Factors; Antihypertensive Agents; Atenolol; Coronary Disease; Human	2017
Pharmacotherapy for hypertension in adults aged 18 to 59 years. The Cochrane database of systematic reviews, 2017, 08-16, Volume: 8 Topics: Adult; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Cause of Death; Coronary Diseas	2017
Beta-blockers and diabetes: the bad guys come good. Cardiovascular drugs and therapy, 2002, Volume: 16, Issue:5 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Bisoprolol; Coronary Disease; Diabet	2002
Rest and the acutely ischaemic heart. The New Zealand medical journal, 1980, Jul-23, Volume: 92, Issue:664 Topics: Adrenergic beta-Antagonists; Bed Rest; Coronary Disease; Humans; Myocardial Infarction; Propranolol	1980
Beta-adrenergic antagonists in the treatment of patients with heart disease. Disease-a-month : DM, 1981, Volume: 27, Issue:9 Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Ca	1981
Beta blocking agents: current status in the prevention of sudden coronary death. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary D	1982
Combined therapy with beta-adrenergic blockers and calcium-antagonists in patients with ischemic heart disease. Herz, 1982, Volume: 7, Issue:4 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Drug Thera	1982
What is optimal drug therapy in angina pectoris? Cardiovascular clinics, 1983, Volume: 13, Issue:1 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arterial Occlusive Diseases; Calcium Channel Blockers;	1983
Acute myocardial infarction--coronary thrombosis and salvage of the ischemic myocardium. Cardiovascular clinics, 1983, Volume: 14, Issue:1 Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Collateral Circulation; Coronary Circulation;	1983
What is the real pharmacological rationale for beta-receptor blocking agents? European heart journal, 1983, Volume: 4 Suppl D Topics: Adrenergic beta-Antagonists; Betaxolol; Coronary Disease; Heart Rate; Humans; Myocardial Contraction	1983
Beta-adrenergic blockade for survivors of acute myocardial infarction. The New England journal of medicine, 1984, Mar-29, Volume: 310, Issue:13 Topics: Adrenergic beta-Antagonists; Aged; Alprenolol; Arrhythmias, Cardiac; Clinical Trials as Topic; Coron	1984
[Withdrawal phenomena after chronic beta-blockade. Causes and therapeutic consequences]. Deutsche medizinische Wochenschrift (1946), 1984, Mar-23, Volume: 109, Issue:12 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Disease; Death	1984
[Beta-blocker withdrawal syndrome]. Klinicheskaia meditsina, 1984, Volume: 62, Issue:3 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Arrhythmias, Cardiac; Catecholamines; Coronar	1984
Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. The New England journal of medicine, 1984, Jun-14, Volume: 310, Issue:24 Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Affinity Labels; Animals; Asthma; Catecholamines; Coron	1984
Beta-blocking drugs for arrhythmias, hypertension, and ischemic heart disease. American journal of surgery, 1984, Volume: 147, Issue:6 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Arrhythmias, Cardiac; Atenolol; Blood Pressur	1984
Short- and long-term influence of beta-adrenergic antagonists after acute myocardial infarction. The American journal of cardiology, 1984, Dec-21, Volume: 54, Issue:11 Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Clinical Trials as Topic; Coronary Disease; Do	1984
Considerations in the long-term management of survivors of cardiac arrest. Annals of the New York Academy of Sciences, 1984, Volume: 432 Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Coronary Artery Bypass; Coronary Disease;	1984
The role of beta-adrenergic receptor antagonists in the prevention of sudden cardiac death. Comprehensive therapy, 1984, Volume: 10, Issue:9 Topics: Action Potentials; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Calcium; Calcium Channel Block	1984
Perioperative cardiac cure. The Urologic clinics of North America, 1983, Volume: 10, Issue:1 Topics: Arrhythmias, Cardiac; Coronary Disease; Digitalis Glycosides; Electrocardiography; Heart Diseases; H	1983
Cardiac risks and complications of noncardiac surgery. Annals of internal medicine, 1983, Volume: 98, Issue:4 Topics: Adult; Aged; Anesthesia; Anti-Bacterial Agents; Coronary Disease; Heart Diseases; Heart Failure; Hem	1983
Nuclear magnetic resonance: theory and review of cardiac applications. American heart journal, 1984, Volume: 108, Issue:3 Pt 1 Topics: Adenosine Triphosphate; Animals; Blood Circulation; Carbon Isotopes; Coronary Circulation; Coronary	1984
Evaluation of left ventricular function by radionuclide angiography during exercise in normal subjects and in patients with chronic coronary heart disease. Journal of the American College of Cardiology, 1983, Volume: 1, Issue:6 Topics: Age Factors; Coronary Disease; Exercise Test; Heart Rate; Heart Ventricles; Humans; Isometric Contra	1983
Radionuclide wall motion study and ejection fraction in clinical practice. The Medical clinics of North America, 1980, Volume: 64, Issue:1 Topics: Aminophylline; Coronary Artery Bypass; Coronary Disease; Doxorubicin; Erythrocytes; Heart; Heart Dis	1980
[Drug treatment of chronic coronary disease]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1980, Jan-15, Volume: 33, Issue:2 Topics: Chronic Disease; Coronary Circulation; Coronary Disease; Humans; Isosorbide Dinitrate; Myocardium; N	1980
[Cardiac surgery. Concepts and achievements in the past 10 years]. Giornale italiano di cardiologia, 1981, Volume: 11 Suppl 1 Topics: Anesthesia; Bioprosthesis; Cardiac Surgical Procedures; Coronary Artery Bypass; Coronary Care Units;	1981
[Diagnosis and treatment of muscular subaortic stenosis]. Kardiologiia, 1980, Volume: 20, Issue:5 Topics: Cardiac Catheterization; Cardiomyopathy, Hypertrophic; Coronary Disease; Death, Sudden; Diagnosis, D	1980
[Utilization of anti-arrhythmic drugs]. Schweizerische medizinische Wochenschrift, 1980, Jul-19, Volume: 110, Issue:29 Topics: Action Potentials; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Digital	1980
Optimal management of patients with ischemic heart disease for noncardiac surgery by complementary anesthesiologist and cardiologist interaction. American heart journal, 1981, Volume: 102, Issue:6 Pt 1 Topics: Aged; Anesthesia; Anesthesiology; Arrhythmias, Cardiac; Cardiology; Cerebrovascular Disorders; Coron	1981
Effect of infarct size limitation by propranolol on ventricular arrhythmias after myocardial infarction. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Dogs; Humans; Myocardial Infarction;	1982
Pharmacokinetic studies: their role in determining therapeutic efficacy of agents designed to prevent sudden death. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Administration, Oral; Anti-Arrhythmia Agents; Coronary Disease; Death, Sudden; Dose-Response Relatio	1982
Antiplatelet therapy in coronary heart disease. Hospital practice (Hospital ed.), 1982, Volume: 17, Issue:5 Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Aspirin; Blood Platelets; Cerebrovascular Disor	1982
Circadian patterns and triggers of sudden cardiac death. Cardiology clinics, 1996, Volume: 14, Issue:2 Topics: Adrenergic beta-Antagonists; Circadian Rhythm; Coronary Disease; Death, Sudden, Cardiac; Defibrillat	1996
[Treatment with beta-blockers in patients with acute coronary syndrome]. Nihon rinsho. Japanese journal of clinical medicine, 1998, Volume: 56, Issue:10 Topics: Acute Disease; Adrenergic beta-Antagonists; Angina, Unstable; Atenolol; Clinical Trials as Topic; Co	1998
Beta-blockers vs. thiazides in the treatment of hypertension: a review of the experience of the large national trials. Journal of cardiovascular pharmacology, 1990, Volume: 16 Suppl 5 Topics: Adrenergic beta-Antagonists; Bendroflumethiazide; Clinical Trials as Topic; Coronary Disease; Diuret	1990
Myocardial infarction size: measurement and modification. Canadian Medical Association journal, 1977, Aug-06, Volume: 117, Issue:3 Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Coronary Disease; Creatine Kinase; Digitalis Glycoside	1977
The role of physical training in patients with coronary artery disease. American heart journal, 1979, Volume: 97, Issue:4 Topics: Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Female; Hemodynamics; Humans; Male; M	1979
Tissue salvage in acute myocardial infarction. American journal of surgery, 1979, Volume: 138, Issue:3 Topics: Animals; Assisted Circulation; Collateral Circulation; Coronary Circulation; Coronary Disease; Creat	1979
[Physical training in the treatment of angina pectoris]. Minerva cardioangiologica, 1979, Volume: 27, Issue:5 Topics: Angina Pectoris; Collateral Circulation; Coronary Disease; Disability Evaluation; Heart Rate; Hemody	1979
Myocardial ischemia (third of three parts). The New England journal of medicine, 1977, May-12, Volume: 296, Issue:19 Topics: Acute Disease; Animals; Assisted Circulation; Coronary Disease; Disease Models, Animal; Dogs; Glucoc	1977
Usefulness of systolic time intervals in coronary artery disease. The American journal of cardiology, 1976, Volume: 37, Issue:5 Topics: Acute Disease; Cardiac Output; Chronic Disease; Coronary Artery Bypass; Coronary Disease; Female; Fo	1976
[Specific and nonspecific effects of beta receptor blockers: stereoselectively different properties exemplified by (R)- and (S)-propranolol]. Wiener medizinische Wochenschrift (1946), 1990, Apr-15, Volume: 140, Issue:6-7 Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Coronary Disease; Exercise Test; Hemodynamics; Hu	1990
Review of antiplatelet drug use in preventing restenosis following percutaneous transluminal coronary angioplasty. The Canadian journal of cardiology, 1988, Volume: 4, Issue:4 Topics: Angioplasty, Balloon; Aspirin; Calcium Channel Blockers; Coronary Disease; Cyclooxygenase Inhibitors	1988
Management of high-risk coronary angioplasty. The American journal of cardiology, 1989, Sep-05, Volume: 64, Issue:9 Topics: Angioplasty, Balloon; Coronary Disease; Humans; Propranolol; Risk Factors	1989
Assessing the total ischemic burden in the management of unstable angina. A review. The American journal of medicine, 1986, Oct-20, Volume: 81, Issue:4A Topics: Adrenergic beta-Antagonists; Angina, Unstable; Coronary Artery Bypass; Coronary Disease; Drug Therap	1986
The coronary circulation and myocardial oxygenation in coronary artery disease: effects of anesthesia. Anesthesia and analgesia, 1986, Volume: 65, Issue:4 Topics: Anesthesia; Calcium Chloride; Coronary Artery Bypass; Coronary Circulation; Coronary Disease; Digoxi	1986
Calcium channel antagonists. Part II: Use and comparative properties of the three prototypical calcium antagonists in ischemic heart disease, including recommendations based on an analysis of 41 trials. Cardiovascular drugs and therapy, 1988, Volume: 1, Issue:5 Topics: Angina Pectoris; Angina, Unstable; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Thera	1988
Smoking, catecholamines, and the ischemic myocardium. Postgraduate medicine, 1988, Feb-29, Volume: Spec No Topics: Angina Pectoris; Atenolol; Catecholamines; Coronary Disease; Female; Heart; Humans; Male; Nifedipine	1988
[Electrocardiographic test of beta-adrenergic blockade from the perspective of 20 years]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1985, Sep-15, Volume: 38, Issue:18 Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Diagnosis, Differential; Electrocardiography; F	1985
[Pharmacological tests in the diagnosis of ischemic heart disease]. Kardiologiia, 1985, Volume: 25, Issue:8 Topics: Atropine; Coronary Disease; Dipyridamole; Ergonovine; Glucose; Heart; Humans; Isoproterenol; Nitrogl	1985
[Beta receptor blockaders in cardiology]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1971, Volume: 60, Issue:45 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Cardiac Complexes,	1971
[Phrmacodynamic principles underlying the specific therapy of coronary vascular disease]. Wiener klinische Wochenschrift, 1973, Feb-23, Volume: 85, Issue:8 Topics: Adenosine; Adrenergic beta-Antagonists; Chemical Phenomena; Chemistry; Coronary Disease; Coronary Ve	1973
Pharmacological therapy of angina pectoris. Modern concepts of cardiovascular disease, 1973, Volume: 42, Issue:2 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arteriosclerosis; Coronary Circulation; Coronary Disea	1973
Indirect assessment of myocardial oxygen consumption in the evaluation of mechanisms and therapy of angina pectoris. The American journal of cardiology, 1974, May-20, Volume: 33, Issue:6 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Coronary Artery Bypass; Coronary Disea	1974
Beta-Blockers in the management of myocardial ischemia. Advances in cardiology, 1974, Volume: 13 Topics: Acute Disease; Adrenergic beta-Antagonists; Angina Pectoris; Cardiac Volume; Coronary Disease; Depre	1974
Vasodilators.. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Adrenergic alpha-Antagonists; Aminophylline; Angina Pectoris; Bradycardia; Bronchial Diseases; Cereb	1974
[Effect of pharmacological substances on the blood supply and work of the heart]. Kardiologiia, 1969, Volume: 9, Issue:6 Topics: Animals; Antithyroid Agents; Blood Flow Velocity; Coronary Disease; Coronary Vessels; Dipyridamole;	1969
Biochemical "defect" in the hypertrophied and failing heart: deleterious or compensatory? Circulation, 1973, Volume: 47, Issue:5 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Calcium; Cardiomegaly; Coronary Disease;	1973
The pathophysiologic vulnerability of the subendocardium of the left ventricle. Advances in cardiology, 1973, Volume: 9 Topics: Arrhythmias, Cardiac; Capillaries; Cardiomegaly; Coronary Disease; Coronary Vessels; Endocardium; He	1973
Pharmacological aspects of the coronary circulation. Progress in medicinal chemistry, 1969, Volume: 6 Topics: Adenine Nucleotides; Angina Pectoris; Angiotensin II; Animals; Atrial Function; Blood Pressure; Coro	1969
[Contribution to the pharmacology of the beta-adrenolytics]. Deutsche medizinische Wochenschrift (1946), 1970, Nov-27, Volume: 95, Issue:48 Topics: Adrenergic beta-Antagonists; Anesthesia, Local; Animals; Arousal; Arrhythmias, Cardiac; Asthma; Card	1970
Angina pectoris: pathophysiology, evaluation, and treatment. Annals of internal medicine, 1971, Volume: 75, Issue:2 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Cardiac Catheterization; Carotid Sinus	1971
Regional myocardial blood flow, ischemia and antianginal drugs. Annals of clinical research, 1971, Volume: 3, Issue:6 Topics: Adrenergic beta-Antagonists; Coronary Circulation; Coronary Disease; Coronary Vessels; Heart; Humans	1971
Antiarrhythmic prophylaxis in ambulatory patients with coronary heart disease. Archives of internal medicine, 1972, Volume: 129, Issue:5 Topics: Ambulatory Care; Arrhythmias, Cardiac; Coronary Disease; Humans; Injections, Intramuscular; Phenytoi	1972
Treatment of ventricular arrhythmias in ambulatory patients. The Medical clinics of North America, 1972, Volume: 56, Issue:3 Topics: Ambulatory Care; Aneurysm; Coronary Disease; Death, Sudden; Electrocardiography; Humans; Pacemaker,	1972
Rational use of antiarrhythmic drugs alone and in combination. Cardiovascular clinics, 1974, Volume: 6, Issue:2 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Digitalis Glycosides; Drug Therapy,	1974
[Variant form of angina pectoris. (Review of literature; case reports; nosologic classification; physiopathogenetic aspects)]. Minerva cardioangiologica, 1972, Volume: 20, Issue:5 Topics: Angina Pectoris; Arteriosclerosis; Asthma; Blood Pressure; Coronary Disease; Electrocardiography; He	1972
Subendocardial distribution of coronary blood flow and the effect of antianginal drugs. Circulation research, 1972, Volume: 30, Issue:6 Topics: Animals; Coronary Circulation; Coronary Disease; Endocardium; Homeostasis; Microspheres; Nitroglycer	1972
Advances in medicine. The Practitioner, 1968, Volume: 201, Issue:204 Topics: Acute Kidney Injury; Asthma; Blindness; Catecholamines; Contraceptives, Oral; Coronary Disease; Guan	1968
[The circulatory system]. Naika. Internal medicine, 1969, Volume: 23, Issue:1 Topics: Angiocardiography; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Cardiac Surgic	1969
[Hydroxybenzylbenzofuran derivatives of pharmacological and therapeutic interest]. Actualites pharmacologiques, 1968, Volume: 21 Topics: Animals; Benzofurans; Capillaries; Cardiovascular System; Coronary Disease; Dipyridamole; Dogs; Guin	1968
Changing concepts in the care of patients with acute myocardial infarction. The Medical journal of Australia, 1969, Jun-07, Volume: 1, Issue:23 Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Blood Gas Analysis; Bundle-Branch Block; Cardiac Output;	1969
[Current problems in the medical treatment of coronary insufficiency]. Medicina interna, 1968, Volume: 20, Issue:8 Topics: Amyl Nitrite; Angina Pectoris; Coronary Disease; Dipyridamole; Humans; Nitroglycerin; Pentaerythrito	1968

Article	Year
Duration of action of beta blockers. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Alprenolol; Atenolol; Blood Pressure; Coronary Disease; Heart Ra	1980
Effect of propranolol and prazosin on blood lipids. The Oslo Study. Lancet (London, England), 1980, Jul-05, Volume: 2, Issue:8184 Topics: Cerebrovascular Disorders; Cholesterol; Coronary Disease; Drug Antagonism; Drug Therapy, Combination	1980
Intravenous beta-blockade in coronary heart disease: is cardioselectivity or intrinsic sympathomimetic activity hemodynamically useful? The New England journal of medicine, 1982, Mar-18, Volume: 306, Issue:11 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Hear	1982
Beta blocking agents: current status in the prevention of sudden coronary death. Annals of the New York Academy of Sciences, 1982, Volume: 382 Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary D	1982
[Double-blind, placebo-controlled trial of propranolol vs celiprolol in stable effort angina: antianginal efficacy and side effects ]. Wiener klinische Wochenschrift, 1982, May-14, Volume: 94, Issue:10 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Celiprolol; Clinical Trials as Topic;	1982
THe beta-Blocker Heart Attack Trial: studies of platelets and factor VIII. Thrombosis research, 1982, Oct-15, Volume: 28, Issue:2 Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Coronary Disease; Factor VIII; Humans; Platelet	1982
[Drug lowering of the HDL concentration in the serum of cardiologically treated patients]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1982, Oct-01, Volume: 37, Issue:19 Topics: Adrenergic beta-Antagonists; Adult; Child; Coronary Disease; Drug Therapy, Combination; Female; Huma	1982
Treatment of ischaemic heart disease with beta-adrenoblocking agents Trimepranol and Obsidan. Cor et vasa, 1983, Volume: 25, Issue:1 Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Humans; Met	1983
Beta-blockers and myocardial infarction: infarction and ischaemia in the practolol and propranolol trials. Australian and New Zealand journal of medicine, 1983, Volume: 13, Issue:2 Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Coronary Disease; Electrocardiography; Humans	1983
[Beta receptor blockers and calcium antagonists in coronary disease. Differential therapeutic aspects]. Deutsche medizinische Wochenschrift (1946), 1983, Jul-29, Volume: 108, Issue:30 Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blocke	1983
Beta-adrenergic blockade for survivors of acute myocardial infarction. The New England journal of medicine, 1984, Mar-29, Volume: 310, Issue:13 Topics: Adrenergic beta-Antagonists; Aged; Alprenolol; Arrhythmias, Cardiac; Clinical Trials as Topic; Coron	1984
[Use of the new beta-adrenoblockader Corgard in ischemic heart disease and arterial hypertension]. Sovetskaia meditsina, 1984, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Coronar	1984
Coronary heart disease mortality/morbidity and risk in blacks. I: Clinical manifestations and diagnostic criteria: the experience with the Beta Blocker Heart Attack Trial. American heart journal, 1984, Volume: 108, Issue:3 Pt 2 Topics: Actuarial Analysis; Adrenergic beta-Antagonists; Black or African American; Cholesterol; Clinical Tr	1984
Coronary heart disease mortality/morbidity and risk in blacks. I: Clinical manifestations and diagnostic criteria: the experience with the Beta Blocker Heart Attack Trial. American heart journal, 1984, Volume: 108, Issue:3 Pt 2 Topics: Actuarial Analysis; Adrenergic beta-Antagonists; Black or African American; Cholesterol; Clinical Tr	1984
Coronary heart disease mortality/morbidity and risk in blacks. I: Clinical manifestations and diagnostic criteria: the experience with the Beta Blocker Heart Attack Trial. American heart journal, 1984, Volume: 108, Issue:3 Pt 2 Topics: Actuarial Analysis; Adrenergic beta-Antagonists; Black or African American; Cholesterol; Clinical Tr	1984
Coronary heart disease mortality/morbidity and risk in blacks. I: Clinical manifestations and diagnostic criteria: the experience with the Beta Blocker Heart Attack Trial. American heart journal, 1984, Volume: 108, Issue:3 Pt 2 Topics: Actuarial Analysis; Adrenergic beta-Antagonists; Black or African American; Cholesterol; Clinical Tr	1984
Short- and long-term influence of beta-adrenergic antagonists after acute myocardial infarction. The American journal of cardiology, 1984, Dec-21, Volume: 54, Issue:11 Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Clinical Trials as Topic; Coronary Disease; Do	1984
Effect of intraoperative propranolol on serum creatine kinase MB release in patients having elective cardiac operations. The Journal of thoracic and cardiovascular surgery, 1984, Volume: 88, Issue:4 Topics: Coronary Artery Bypass; Coronary Disease; Creatine Kinase; Heart Arrest, Induced; Heart Valve Prosth	1984
Controversies in hypertension: mild hypertension, isolated systolic hypertension, and the choice of a step one drug. Clinical cardiology, 1983, Volume: 6, Issue:1 Topics: Adult; Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Clinical Trials as Topic;	1983
[Effectiveness of obsidan in patients with ischemic heart disease and its effect on myocardial perfusion]. Kardiologiia, 1983, Volume: 23, Issue:9 Topics: Adult; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Coronary Vessels; Follow-Up	1983
Beta-blockade in ischaemic heart disease--influence of concomitant ISA or alpha-blockade on haemodynamic profile. Postgraduate medical journal, 1983, Volume: 59 Suppl 3 Topics: Adult; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Ethanolamines;	1983
Comparative effects of oral acebutolol and propranolol at rest and during exercise in ischemic heart disease: double-blind placebo crossover study utilizing radionuclide ventriculography. American heart journal, 1984, Volume: 108, Issue:3 Pt 1 Topics: Acebutolol; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Me	1984
Issues in the natural history and treatment of coronary heart disease in black populations: medical management. American heart journal, 1984, Volume: 108, Issue:3 Pt 2 Topics: Adult; Aged; Black or African American; California; Cardiovascular Diseases; Clinical Trials as Topi	1984
Influence of propranolol, metoprolol, and pindolol on mucociliary clearance in patients with coronary heart disease. Respiration; international review of thoracic diseases, 1984, Volume: 45, Issue:3 Topics: Adult; Aged; Bronchi; Cilia; Coronary Disease; Female; Humans; Lung; Male; Metoprolol; Middle Aged;	1984
Arrhythmias after coronary bypass surgery. British heart journal, 1984, Volume: 51, Issue:6 Topics: Adult; Aged; Arrhythmias, Cardiac; Bundle-Branch Block; Coronary Artery Bypass; Coronary Disease; Di	1984
Comparative haemodynamic dose-response effects of intravenous propranolol and pindolol in patients with coronary heart disease. European journal of clinical pharmacology, 1983, Volume: 25, Issue:2 Topics: Adult; Angina Pectoris; Coronary Disease; Dose-Response Relationship, Drug; Female; Heart; Hemodynam	1983
[Comparative study of the effect of the calcium antagonist nifedipine, the beta receptor blockers acebutolol and propranolol and their combination on electrophysiologic parameters in the human]. Zeitschrift fur Kardiologie, 1984, Volume: 73, Issue:2 Topics: Acebutolol; Cardiac Catheterization; Coronary Disease; Drug Therapy, Combination; Electrocardiograph	1984
Comparative effects of alinidine and propranolol in ischaemic heart disease. European journal of clinical pharmacology, 1982, Volume: 23, Issue:5 Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Coronary Angiography; Coronary Disease; Double-	1982
[Prospective randomized study of the therapeutic action of propranolol compared to diltiazem in unstable stenocardia]. Terapevticheskii arkhiv, 1982, Volume: 54, Issue:11 Topics: Angina Pectoris; Benzazepines; Clinical Trials as Topic; Coronary Disease; Diltiazem; Electrocardiog	1982
[Polycardiographic and ergometric studies after administration of atenolol and propranolol]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1982, Nov-15, Volume: 35, Issue:21 Topics: Atenolol; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Depression, Chemical; Heart Fu	1982
Therapy of coronary vasoconstriction in patients with coronary artery disease. The American journal of cardiology, 1981, Volume: 47, Issue:1 Topics: Angina Pectoris; Cold Temperature; Coronary Disease; Coronary Vessels; Exercise Test; Heart Ventricl	1981
Exacerbation of vasotonic angina pectoris by propranolol. Circulation, 1982, Volume: 65, Issue:2 Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Coronary Vasospasm; Double-Blind	1982
Radionuclide evaluation of CHF. Acta medica Scandinavica. Supplementum, 1981, Volume: 652 Topics: Adolescent; Adult; Coronary Disease; Digoxin; Female; Heart Aneurysm; Heart Failure; Hemodynamics; H	1981
Blood pressure and heart rate in patients with ischaemic heart disease receiving nifedipine and propranolol. British medical journal (Clinical research ed.), 1982, Apr-17, Volume: 284, Issue:6323 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Drug T	1982
Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease. British medical journal (Clinical research ed.), 1982, Jul-31, Volume: 285, Issue:6338 Topics: Adult; Blood Pressure; Cardiac Output; Coronary Disease; Ethanolamines; Hemodynamics; Humans; Labeta	1982
Effect of beta adrenergic blockade on thallium-201 myocardial perfusion imaging. British heart journal, 1983, Volume: 49, Issue:1 Topics: Adult; Angina Pectoris; Coronary Disease; Exercise Test; Heart; Humans; Male; Middle Aged; Propranol	1983
Effects of propranolol on blood lipids and lipoproteins in myocardial infarction. Circulation, 1983, Volume: 67, Issue:6 Pt 2 Topics: Adult; Aged; Cholesterol; Coronary Disease; Female; Humans; Lipoproteins; Male; Middle Aged; Myocard	1983
The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study. Circulation, 1983, Volume: 68, Issue:3 Topics: Aged; Angina Pectoris; Benzazepines; Cardiac Output; Coronary Disease; Diltiazem; Drug Therapy, Comb	1983
Relation between ST-depression and chest pain in patients with coronary heart disease receiving no treatment and after beta-blockade and combined alpha-beta-blockade. Acta medica Scandinavica. Supplementum, 1981, Volume: 644 Topics: Aged; Angina Pectoris; Blood Pressure; Coronary Disease; Electrocardiography; Ethanolamines; Exercis	1981
Left ventricular function and beta-blockade in chronic ischaemic heart failure. Double-blind, cross-over study of propranolol and penbutolol using non-invasive techniques. British heart journal, 1980, Volume: 44, Issue:1 Topics: Clinical Trials as Topic; Coronary Disease; Digoxin; Double-Blind Method; Heart Failure; Heart Ventr	1980
Treatment of mild hypertension: a five year controlled drug trial. The Oslo study. The American journal of medicine, 1980, Volume: 69, Issue:5 Topics: Adult; Blood Pressure; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disease; Drug T	1980
Effect of timolol on platelet aggregation in coronary heart disease. Acta medica Scandinavica. Supplementum, 1981, Volume: 651 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Female	1981
A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. JAMA, 1982, Mar-26, Volume: 247, Issue:12 Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Double-Blind	1982
A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. JAMA, 1982, Mar-26, Volume: 247, Issue:12 Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Double-Blind	1982
A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. JAMA, 1982, Mar-26, Volume: 247, Issue:12 Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Double-Blind	1982
A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. JAMA, 1982, Mar-26, Volume: 247, Issue:12 Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Double-Blind	1982
Comparative effects of oral verapamil and propranolol on exercise-induced myocardial ischemia and energetics in patients with coronary artery disease: single-blind placebo crossover evaluation using radionuclide ventriculography. American heart journal, 1982, Volume: 103, Issue:6 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Electrocardiography; Exerci	1982
Unstable angina pectoris: management based on available information. Circulation, 1982, Volume: 65, Issue:7 Pt 2 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Artery Bypass; Coronary Disease; Humans; Nitrate	1982
Effect of propranolol on myocardial perfusion images and exercise ejection fraction in men with coronary artery disease. Circulation, 1982, Volume: 65, Issue:1 Topics: Angina Pectoris; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Disease; Double-Blin	1982
Effects of verapamil and propranolol on left ventricular systolic function and diastolic filling in patients with coronary artery disease: radionuclide angiographic studies at rest and during exercise. Circulation, 1982, Volume: 65, Issue:7 Topics: Adult; Blood Pressure; Coronary Disease; Erythrocytes; Female; Heart; Heart Rate; Heart Ventricles;	1982
Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease. British heart journal, 1982, Volume: 48, Issue:4 Topics: Adult; Coronary Disease; Dose-Response Relationship, Drug; Ethanolamines; Heart Ventricles; Hemodyna	1982
Treatment of angina pectoris with propranolol: the harmful effects of cigarette smoking. Cardiology, 1981, Volume: 68 Suppl 2 Topics: Angina Pectoris; Blood Pressure; Coronary Disease; Electrocardiography; Exercise Test; Heart Rate; H	1981
Prevention of nifedipine of abnormal coronary vasoconstriction in patients with coronary artery disease. Circulation, 1981, Volume: 63, Issue:4 Topics: Adult; Aged; Blood Pressure; Cardiac Catheterization; Cold Temperature; Coronary Disease; Coronary V	1981
Protective effect of beta-blockade on dipyridamole-induced myocardial ischaemia. Role of heart rate. European heart journal, 1995, Volume: 16, Issue:7 Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiac Pacing, Artificial; Coronary Disease; Dipyridamole	1995
Celiprolol and propranolol for unstable angina pectoris. Clinical pharmacology and therapeutics, 1995, Volume: 57, Issue:1 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Angina, Unstable; Celiprolol; Coronary Disease	1995
Decrease in mortality by propranolol in patients with heart disease and complex ventricular arrhythmias is more an anti-ischemic than an antiarrhythmic effect. The American journal of cardiology, 1994, Sep-15, Volume: 74, Issue:6 Topics: Aged; Aged, 80 and over; Coronary Disease; Humans; Middle Aged; Propranolol; Prospective Studies; Si	1994
[Acute effects of propranolol and its association with nifedipine in aged patients with effort stable angina. Randomized double-blind crossover study, under placebo control]. Minerva cardioangiologica, 1993, Volume: 41, Issue:4 Topics: Age Factors; Aged; Angina Pectoris; Coronary Disease; Double-Blind Method; Drug Therapy, Combination	1993
Usefulness of exercise testing performed with vasodilators for predicting the severity of myocardial ischaemia during daily activities and treatment. European heart journal, 1993, Volume: 14, Issue:3 Topics: Activities of Daily Living; Adult; Angina Pectoris; Coronary Circulation; Coronary Disease; Drug The	1993
Beta-adrenergic blockade decreases coronary collateral blood flow in patients with coronary artery disease. Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:6 Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Collateral Circulation; Coronary	1998
[Effects of nitrates and beta-blockers on platelet aggregation in patients with coronary heart disease]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2000, Volume: 8, Issue:44 Topics: Adrenergic beta-Antagonists; Adult; Aged; Coronary Disease; Dose-Response Relationship, Drug; Female	2000
Effect of beta-blockade on the premature ventricular beats/heart rate relation and heart rate variability in patients with coronary heart disease and severe ventricular arrhythmias. American journal of therapeutics, 2000, Volume: 7, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; E	2000
Amiodarone versus a beta-blocker to prevent atrial fibrillation after cardiovascular surgery. American heart journal, 2001, Volume: 142, Issue:5 Topics: Aged; Amiodarone; Atrial Fibrillation; Coronary Artery Bypass; Coronary Disease; Heart Valves; Human	2001
[A double blind cross-over study with mepindolol-sulfate in patients with coronary heart disease (author's transl)]. Wiener medizinische Wochenschrift (1946), 1979, Oct-20, Volume: 129, Issue:19 Topics: Adrenergic beta-Antagonists; Aged; Coronary Disease; Double-Blind Method; Drug Evaluation; Female; H	1979
[Effect of nitroglycerin, digoxin and inderal of myocardial asynergy in ischemic heart disease]. Kardiologiia, 1978, Volume: 18, Issue:9 Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Digoxin; Drug Evaluation;	1978
[Effect of verapamil on echocardiographic dimensions of the left ventricle in ischemic cardiopathy: comparison with placebo, propranolol and trinitroglycerin]. Bollettino della Societa italiana di cardiologia, 1979, Volume: 24, Issue:6 Topics: Adult; Clinical Trials as Topic; Coronary Disease; Echocardiography; Humans; Male; Middle Aged; Myoc	1979
The effects of oral propranolol, digoxin and combination therapy on the resting and exercise electrocardiogram. American heart journal, 1977, Volume: 93, Issue:2 Topics: Administration, Oral; Adult; Clinical Trials as Topic; Coronary Disease; Digoxin; Drug Therapy, Comb	1977
Effects of drugs upon exercise tests in coronary insuffiency. Arquivos brasileiros de cardiologia, 1977, Volume: 30 Suppl 1 Topics: Adult; Clinical Trials as Topic; Coronary Disease; Drug Evaluation; Electrocardiography; Exercise Te	1977
Effects of oxprenolol and propranolol on systolic time intervals. Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:6 Topics: Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Heart Rate; Humans;	1978
The influence of combined treatment with propranolol and acetylsalicylic acid on platelet aggregation in coronary heart disease. British journal of clinical pharmacology, 1979, Volume: 7, Issue:3 Topics: Adult; Aspirin; Clinical Trials as Topic; Coronary Disease; Drug Interactions; Epinephrine; Fibrinog	1979
First pass uptake of 14C-propranolol by the lung. Thorax, 1979, Volume: 34, Issue:6 Topics: Administration, Oral; Adult; Carbon Radioisotopes; Cardiac Catheterization; Clinical Trials as Topic	1979
[Hemodynamic differences in the effects of mepindolol-sulfate and propranolol after 4 weeks treatment under conditions of rest and physical exercise in patients with coronary heart disease (author's transl)]. Zeitschrift fur Kardiologie, 1978, Volume: 67, Issue:1 Topics: Aged; Blood Pressure; Coronary Disease; Depression, Chemical; Female; Heart Rate; Hemodynamics; Huma	1978
Unstable angina pectoris: a randomized study of patients treated medically and surgically. The American journal of cardiology, 1978, Volume: 41, Issue:7 Topics: Angina Pectoris; Cardiac Catheterization; Coronary Disease; Exercise Test; Female; Follow-Up Studies	1978
Verapamil in ischaemic heart disease--quantitative assessment by serial multistage treadmill exercise. Postgraduate medical journal, 1976, Volume: 52, Issue:605 Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Drug Evaluation; Exercise	1976
Treatment of spontaneous angina pectoris with beta blocking agents. A clinical, electrocardiographic, and haemodynamic appraisal. British heart journal, 1975, Volume: 37, Issue:12 Topics: Angina Pectoris; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Coronary Disease; Dose-Re	1975
Efficacy of beta adrenergic blockade in coronary heart disease: propranolol in angina pectoris. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:5 Pt 1 Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Exercise Test; Female; Hum	1975
Role of non-invasive methods in clinical evaluation of drugs in ischaemic heart disease. Bibliotheca cardiologica, 1976, Issue:35 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Echoc	1976
Prospective randomized study of coronary bypass surgery in stable angina. The first 100 patients. Circulation, 1975, Volume: 52, Issue:2 Suppl Topics: Angina Pectoris; Coronary Artery Bypass; Coronary Disease; Evaluation Studies as Topic; Exercise Tes	1975
Comparative effects of tolamolol and propranolol on cardiac and peripheral circulatory function in patients with coronary artery disease. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:6 Topics: Adult; Aged; Blood Circulation; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Coronary C	1975
Propranolol-withdrawal rebound phenomenon. Exacerbation of coronary events after abrupt cessation of antianginal therapy. The New England journal of medicine, 1975, Aug-28, Volume: 293, Issue:9 Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Hum	1975
Editorial: Propranolol withdrawal. The New England journal of medicine, 1975, Aug-28, Volume: 293, Issue:9 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Artery Bypass; Coronary Disease; Humans; Myocard	1975
Acute hemodynamic effects of carvedilol in comparison with propranolol in patients with coronary heart disease. The Clinical investigator, 1992, Volume: 70 Suppl 1 Topics: Adrenergic beta-Antagonists; Adult; Angioplasty, Balloon, Coronary; Antihypertensive Agents; Carbazo	1992
[Effects of beta blocking agent iontophoresis by modulated sinusoidal current]. La Clinica terapeutica, 1992, Volume: 140, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Coronary Artery Bypass; Coronary Disease; Heart Rate; Humans; Io	1992
Effect of beta-adrenoceptor blockade on dipyridamole-induced myocardial asynergies in coronary artery disease. The American journal of cardiology, 1992, Sep-15, Volume: 70, Issue:7 Topics: Adrenergic beta-Antagonists; Coronary Angiography; Coronary Disease; Dipyridamole; Echocardiography;	1992
Myocardial protection with carvedilol. Journal of cardiovascular pharmacology, 1992, Volume: 19 Suppl 1 Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Carvedilol; Coronary Disease; Dogs; Heart; Injecti	1992
Treatment of transient myocardial ischemia in patients with stable angina: a comparative study of verapamil slow-release and nifedipine plus propranolol. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:4 Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Delayed-Action Preparations; Drug Therapy, Combinati	1992
The influence of adrenoreactive preparations on clinical and haemodynamic parameters in patients with ischaemic heart disease. Cor et vasa, 1991, Volume: 33, Issue:1 Topics: Adult; Angina Pectoris; Coronary Artery Disease; Coronary Disease; Double-Blind Method; Exercise Tes	1991
[Effect of adrenergic beta blockers on hemodynamics, diastolic relaxation and distensibility of left-ventricular myocardium in patients with ischemic heart disease]. Klinicheskaia meditsina, 1991, Volume: 69, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Coronary Disease; Hemodynamics; Humans; Infant; Middle Aged; Myo	1991
[Neither propranolol nor the vasodilating beta-blocker carvedilol have a direct effect on coronary resistance vessels]. Zeitschrift fur Kardiologie, 1991, Volume: 80, Issue:1 Topics: Adrenergic beta-Antagonists; Blood Flow Velocity; Blood Pressure; Carbazoles; Carvedilol; Coronary A	1991
Home blood pressure monitoring: advantages and limitations. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991, Volume: 9, Issue:3 Topics: Blood Pressure Determination; Clonidine; Coronary Disease; Double-Blind Method; Humans; Hypertension	1991
Relations between heart rate, ischemia, and drug therapy during daily life in patients with coronary artery disease. Circulation, 1991, Volume: 83, Issue:4 Topics: Activities of Daily Living; Administration, Cutaneous; Coronary Disease; Double-Blind Method; Electr	1991
[Effects of antianginal drugs on left ventricular diastolic filling in patients with ischemic heart disease]. Kokyu to junkan. Respiration & circulation, 1991, Volume: 39, Issue:8 Topics: Aged; Coronary Disease; Diastole; Drug Evaluation; Exercise Test; Gated Blood-Pool Imaging; Heart; H	1991
Potentiation of cocaine-induced coronary vasoconstriction by beta-adrenergic blockade. Annals of internal medicine, 1990, Jun-15, Volume: 112, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Cocaine; Coronary Circulation; Coronary Di	1990
Influence of carvedilol and propranolol on coronary blood flow. European journal of clinical pharmacology, 1990, Volume: 38 Suppl 2 Topics: Adrenergic beta-Antagonists; Blood Pressure; Carbazoles; Carvedilol; Coronary Circulation; Coronary	1990
[Effects of obsidan on hemodynamic indices and clinical manifestations of angina pectoris in patients with ischemic heart disease during psychoemotional stress]. Kardiologiia, 1991, Volume: 31, Issue:2 Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Coronary Disease; Electrocardiography; Heart Rate; Hem	1991
Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischemia in patients with stable angina. Differential effects on ambulatory ischemia, exercise performance, and anginal symptoms. The ASIS Study Group. Circulation, 1990, Volume: 82, Issue:6 Topics: Angina Pectoris; Blood Pressure; Coronary Disease; Diltiazem; Electrocardiography, Ambulatory; Exerc	1990
Comparison of the acute hemodynamic effects of intravenous celiprolol and propranolol in patients with suspected coronary disease. Journal of cardiovascular pharmacology, 1986, Volume: 8 Suppl 4 Topics: Adult; Cardiac Catheterization; Celiprolol; Coronary Disease; Female; Hemodynamics; Humans; Male; Mi	1986
Acute hemodynamic effects of the vasodilating and beta-blocking agent carvedilol in comparison to propranolol. Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 11 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Carbazoles; Carvedilol; Coronary Disease; Double	1987
Intracoronary injections of salbutamol demonstrate the presence of functional beta 2-adrenoceptors in the human heart. Circulation research, 1989, Volume: 65, Issue:3 Topics: Albuterol; Angina Pectoris; Blood Pressure; Cardiac Catheterization; Cardiac Output; Coronary Diseas	1989
The effect of beta blockade on single photon emission computed tomographic (SPECT) thallium-201 images in patients with coronary disease. American heart journal, 1989, Volume: 117, Issue:5 Topics: Adrenergic beta-Agonists; Algorithms; Betaxolol; Blood Pressure; Coronary Disease; Exercise; Female;	1989
[The acute hemodynamic effects of the new vasodilating beta blocker carvedilol in comparison with combined administration of nifedipine and propranolol in patients with coronary heart disease]. Zeitschrift fur Kardiologie, 1989, Volume: 78, Issue:11 Topics: Carbazoles; Carvedilol; Coronary Circulation; Coronary Disease; Drug Therapy, Combination; Female; H	1989
[Effect of calcium antagonists and beta receptor blockers on coronary vessel diameter]. Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 5 Topics: Angina Pectoris; Atenolol; Coronary Angiography; Coronary Circulation; Coronary Disease; Gallopamil;	1989
[The anti-ischemic effect of isosorbide dinitrate alone and in combination with gallopamil and propranolol]. Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 2 Topics: Adult; Angina Pectoris; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Dru	1989
Beneficial effects of pinacidil on blood lipids: comparisons with prazosin and placebo in patients with hypertension. Pinacidil-Prazosin and Pinacidil-Placebo Research Groups, Lilly Research Laboratories. The Journal of laboratory and clinical medicine, 1989, Volume: 114, Issue:6 Topics: Antihypertensive Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic;	1989
Improvement in wall motion after pindolol: a mechanism for the preservation of left ventricular function in coronary artery disease. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1989, Volume: 22, Issue:7 Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Cardiac Catheterization; Clinical Trials as Topic	1989
Beta-blocking potency and electrophysiologic effects of acebutolol. American heart journal, 1985, Volume: 109, Issue:5 Pt 2 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Atrioventricular Node; Blood Pressure; Coronar	1985
MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party. British medical journal (Clinical research ed.), 1985, Jul-13, Volume: 291, Issue:6488 Topics: Adult; Bendroflumethiazide; Blood Pressure; Cerebrovascular Disorders; Clinical Trials as Topic; Cor	1985
Beta blockade and intermittent claudication. Acta medica Scandinavica. Supplementum, 1985, Volume: 700 Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Female; Gait;	1985
Coronary heart disease and treatment of hypertension. Some Oslo Study data. The American journal of medicine, 1986, Feb-14, Volume: 80, Issue:2A Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Blood Glucose; Carbohydrate	1986
Myocardial protection during transient coronary artery occlusion in man: beneficial effects of regional beta-adrenergic blockade. Circulation, 1986, Volume: 73, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Aged; Angioplasty, Balloon; Coronary Disease; Coronary Vessels;	1986
The Beta-blocker Heart Attack Trial. Zeitschrift fur Kardiologie, 1985, Volume: 74 Suppl 6 Topics: Adrenergic beta-Antagonists; Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Coronary D	1985
Clinical experience with esmolol, a short-acting beta-adrenergic blocker in cardiac arrhythmias and myocardial ischemia. Journal of clinical pharmacology, 1986, Volume: 26, Issue:S1 Topics: Adrenergic beta-Antagonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; C	1986
Differences in haemodynamic response to beta-blocking drugs between stable coronary artery disease and acute myocardial infarction. European journal of clinical pharmacology, 1986, Volume: 29, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Clinical Trials as Topic; Coronary Disease; Heart Rate; Hemodyna	1986
Oslo Hypertension Study. Drugs, 1986, Volume: 31 Suppl 1 Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Cholesterol, HDL; Coronary Disease; Follow-Up Stu	1986
Role of cardioselectivity and intrinsic sympathomimetic activity in beta-blocking drugs in chronic coronary artery disease. The American journal of cardiology, 1987, May-15, Volume: 59, Issue:13 Topics: Acebutolol; Adrenergic beta-Antagonists; Chronic Disease; Clinical Trials as Topic; Coronary Disease	1987
Coronary heart disease in the Medical Research Council trial of treatment of mild hypertension. Medical Research Council Working Party on Mild Hypertension. British heart journal, 1988, Volume: 59, Issue:3 Topics: Adult; Bendroflumethiazide; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Human	1988
Non-surgical strategies to prevent death in coronary artery disease. Medical Section proceedings : the ... annual Meeting of the Medical Section of the American Council of Life Insurance. American Council of Life Insurance. Medical Section. Meeting, 1985 Topics: Adult; Angioplasty, Balloon; Cholesterol, Dietary; Clinical Trials as Topic; Coronary Disease; Femal	1985
Effect of hyaluronidase on mortality and morbidity in patients with early peaking of plasma creatine kinase MB and non-transmural ischaemia. Multicentre investigation for the limitation of infarct size (MILIS). British heart journal, 1988, Volume: 60, Issue:4 Topics: Clinical Trials as Topic; Coronary Disease; Creatine Kinase; Double-Blind Method; Humans; Hyaluronog	1988
The mild hypertension dilemma: results of the British MRC trial. Journal of clinical hypertension, 1986, Volume: 2, Issue:3 Suppl Topics: Adult; Antihypertensive Agents; Bendroflumethiazide; Cardiovascular Diseases; Cerebrovascular Disord	1986
Ten-year effect of medical and surgical therapy on quality of life: Veterans Administration Cooperative Study of Coronary Artery Surgery. The American journal of cardiology, 1987, May-01, Volume: 59, Issue:12 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Artery Bypass; Coronary Disease; Exercise Test;	1987
Stroke and coronary heart disease in mild hypertension: risk factors and the value of treatment. Medical Research Council Working Party. British medical journal (Clinical research ed.), 1988, Jun-04, Volume: 296, Issue:6636 Topics: Adult; Age Factors; Bendroflumethiazide; Blood Pressure; Cerebrovascular Disorders; Coronary Disease	1988
[Use of a static exercise test for evaluating anti-angina effects of drugs in patients with ischemic heart disease at a polyclinic]. Kardiologiia, 1988, Volume: 28, Issue:10 Topics: Adult; Aged; Ambulatory Care; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Electroca	1988
Smoking, catecholamines, and the ischemic myocardium. Postgraduate medicine, 1988, Feb-29, Volume: Spec No Topics: Angina Pectoris; Atenolol; Catecholamines; Coronary Disease; Female; Heart; Humans; Male; Nifedipine	1988
Relationship of blood pressure to coronary and stroke morbidity and mortality in clinical trials and epidemiological studies. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1986, Volume: 4, Issue:6 Topics: Blood Pressure; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disease; Diuretics; Ep	1986
Further results of the MRC treatment trial for mild hypertension. Nephron, 1987, Volume: 47 Suppl 1 Topics: Bendroflumethiazide; Cerebrovascular Disorders; Clinical Trials as Topic; Coronary Disease; Death, S	1987
Changes in haemodynamics and left ventricular function during intravenous nifedipine infusion with and without additional propranolol in patients with coronary artery disease. A randomized, placebo controlled trial. European journal of clinical pharmacology, 1987, Volume: 33, Issue:4 Topics: Angiography; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Heart; Heart Rate; Hem	1987
Comparison of AQ-A 39 with propanolol and placebo in ischaemic heart disease. European heart journal, 1987, Volume: 8 Suppl L Topics: Anti-Arrhythmia Agents; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Heart Rate; Huma	1987
The Medical Research Council Hypertension Trial: the smoking patient. American heart journal, 1988, Volume: 115, Issue:1 Pt 2 Topics: Adult; Bendroflumethiazide; Cerebrovascular Disorders; Coronary Disease; Female; Humans; Hypertensio	1988
Calcium-channel blockers for combined angina pectoris and systemic hypertension. The American journal of cardiology, 1986, Feb-26, Volume: 57, Issue:7 Topics: Adult; Aged; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chr	1986
Acute, short- and long-term efficacy of oral bevantolol in patients with coronary artery disease: a placebo-controlled, randomized, double-blind study. Clinical cardiology, 1986, Volume: 9, Issue:9 Topics: Administration, Oral; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; D	1986
Equal anti-ischemic properties of isosorbide dinitrate plus verapamil and isosorbide dinitrate plus propranolol. A randomized, double-blind and crossover study. Zeitschrift fur Kardiologie, 1986, Volume: 75 Suppl 3 Topics: Blood Pressure; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Drug Therapy, Combi	1986
Effect of diltiazem and propranolol on myocardial ischaemia during unrestricted daily life in patients with effort-induced chronic stable angina pectoris. European journal of clinical pharmacology, 1987, Volume: 32, Issue:5 Topics: Aged; Coronary Disease; Diltiazem; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Age	1987
Effect of propranolol on indices of intermittent myocardial ischemia, assessed by exercise testing and ambulatory ST-segment monitoring. Clinical cardiology, 1986, Volume: 9, Issue:8 Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Double-Blind Method; Electrocardiography; Exercise T	1986
Long-term management of exercise-induced myocardial ischemia. Diltiazem versus propranolol, a double-blind, crossover study. International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:10 Topics: Adult; Coronary Disease; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Female;	1986
A randomized study comparing propranolol and diltiazem in the treatment of unstable angina. Journal of the American College of Cardiology, 1985, Volume: 5, Issue:3 Topics: Aged; Angina Pectoris; Angina, Unstable; Benzazepines; Clinical Trials as Topic; Coronary Disease; D	1985
Calcium blockers and beta blockers: alone and in combination. Acta medica Scandinavica. Supplementum, 1985, Volume: 694 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Electrocardi	1985
[Role of many hours of ECG monitoring (Holter method) in the diagnosis of ischemic heart disease and the selection and evaluation of antianginal therapy]. Kardiologiia, 1985, Volume: 25, Issue:9 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Angiography; Coronary Disease; Electrocardiograp	1985
Hemodynamic effects of intravenous diltiazem in patients treated chronically with propranolol. American heart journal, 1986, Volume: 111, Issue:1 Topics: Adult; Aged; Benzazepines; Coronary Disease; Diltiazem; Hemodynamics; Humans; Infusions, Parenteral;	1986
Effect of coffee on exercise-induced angina pectoris due to coronary artery disease in habitual coffee drinkers. The American journal of cardiology, 1985, Feb-01, Volume: 55, Issue:4 Topics: Adult; Aged; Angina Pectoris; Caffeine; Chronic Disease; Coffee; Coronary Disease; Drinking Behavior	1985
Double blind cross-over study of the inotropic influence of Tiprenolol (DU21445) and propranolol in patients with ischaemic heart disease. Australian and New Zealand journal of medicine, 1973, Volume: 3, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Brachial Artery; Cardiac Output; Cardiac Volume;	1973
Effect of tolamolol versus propranolol on cardiovascular haemodynamics in patients with angina. British heart journal, 1974, Volume: 36, Issue:11 Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Angiography; Benzamides; Blood Pressure; Cardia	1974
Absence of prophylactic effect of propranolol in myocardial infarction. Lancet (London, England), 1966, Oct-29, Volume: 2, Issue:7470 Topics: Arrhythmias, Cardiac; Aspartate Aminotransferases; Coronary Disease; Electrocardiography; Female; He	1966
Haemodynamic changes in patients with coronary heart disease after beta-adrenergic blockade with propranolol. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 4, Issue:4 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atrial Function; Blood Pressure; Cardiac Output; Cli	1970
The effects of oxprenolol (Trasicor, Ciba 39089-Ba) on patterns of urinary sodium excretion in man. The American journal of cardiology, 1971, Volume: 27, Issue:4 Topics: 1-Propanol; Adrenergic beta-Antagonists; Adult; Amino Alcohols; Cardiomyopathy, Hypertrophic; Circad	1971
[Determination of effort tolerance in coronary patients after Intencordin and propranolol administration]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1973, Oct-22, Volume: 28, Issue:43 Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Coumarins; Diethylamines; Electrocardiograp	1973
Haemodynamic effects of beta-receptor blocking agents and digitalis in ischaemic coronary heart disease with angina pectoris. Acta medica Scandinavica, 1973, Volume: 194, Issue:6 Topics: Angina Pectoris; Blood Pressure; Brachial Artery; Cardiac Catheterization; Cardiac Output; Coronary	1973
Reversal of abnormal platelet aggregability and change in exercise tolerance in patients with angina pectoris following oral propranolol. Circulation, 1974, Volume: 50, Issue:5 Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aged; Angina Pectoris; Clinical Trials as Topic;	1974
[Problems in the clinical testing of drugs]. Ugeskrift for laeger, 1968, Jan-04, Volume: 130, Issue:1 Topics: Alkaline Phosphatase; Clinical Trials as Topic; Coronary Disease; Creatinine; Drug Utilization; Elec	1968
New dimension in angina pectoris therapy. Geriatrics, 1969, Volume: 24, Issue:3 Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Drug Synergism; Electrocar	1969
[On the use of beta-receptor-blocking agents in heart therapy]. Die Medizinische Welt, 1967, Jul-15, Volume: 28 Topics: Adult; Clinical Trials as Topic; Coronary Disease; Humans; Middle Aged; Propranolol; Sympatholytics	1967
[Treatment of chronic coronary insufficiency]. Kardiologiia, 1968, Volume: 8, Issue:11 Topics: Adult; Aged; Anabolic Agents; Angina Pectoris; Blood Flow Velocity; Blood Pressure; Blood Volume; Ca	1968
Evaluation of long-term use of propranolol in angina pectoris. JAMA, 1969, Oct-06, Volume: 210, Issue:1 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Female; Heart Failure; Humans; Male; Mi	1969
[Results of clinical testing of carbochromen in chronic coronary insufficiency]. Arzneimittel-Forschung, 1970, Volume: 20 Topics: Adult; Aged; Antihypertensive Agents; Aortic Arch Syndromes; Blood Circulation; Blood Volume; Cardia	1970
Propranolol in angina pectoris. Archives of internal medicine, 1969, Volume: 124, Issue:5 Topics: Adult; Aged; Angina Pectoris; Arteriosclerosis; Blood Pressure; Clinical Trials as Topic; Coronary D	1969
[The effect of propranolol and nitroglycerine on the electrocardiogram and the intrapulmonary pressure values during physical exercise of patients with angina pectoris]. Deutsche medizinische Wochenschrift (1946), 1970, Dec-25, Volume: 95, Issue:52 Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Coronary Disease; Electrocardiography; Heart Rate; Hum	1970
[Clinical trial of drugs affecting coronary insufficiency]. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1970, Volume: 4, Issue:1 Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Coronary Vessels; Exerc	1970
Effect of propranolol (inderal) on exercise tolerance in angina pectoris. British heart journal, 1966, Volume: 28, Issue:3 Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Exercise Test; Female; Humans; Ma	1966
Haemodynamic effects of I.C.I. 50172 in patients with ischaemic heart disease. British medical journal, 1968, Jan-27, Volume: 1, Issue:5586 Topics: Acetanilides; Adult; Aged; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Coronary Disease;	1968
[Hemodynamic changes following blockade of the beta-receptors in healthy persons and in patients with coronary heart disease. Comparison between Trasicor and Inderal]. Schweizerische medizinische Wochenschrift, 1968, Jun-22, Volume: 98, Issue:25 Topics: Adolescent; Adult; Aged; Amino Alcohols; Arteries; Blood Pressure; Cardiac Output; Coronary Disease;	1968

propranolol and Coronary Disease

Research Excerpts

Research

Studies (1,083)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Incidence of Mortality

Incidence of Unexpected Adverse Events

Number of Participants With Incidence of Stroke

Postoperative Increase of Plasma NT-proBNP

Postoperative Increase of Plasma NT-proBNP in Patients Without Diabetes

Postoperative Plasma Level of NT-proBNP

Postoperative Plasma Level of NT-proBNP

Reviews

Trials

Other Studies

Intervention	ng/L (Mean)
Intravenous Glutamate Infusion	8055
Intravenous Saline Infusion	8804

Authors	Studies
Suita, K	1
Yagisawa, Y	1
Ohnuki, Y	1
Umeki, D	1
Nariyama, M	1
Ito, A	1
Hayakawa, Y	1
Matsuo, I	1
Mototani, Y	1
Saeki, Y	1
Okumura, S	1
Zhang, Y	1
Sun, N	1
Jiang, X	1
Xi, Y	1
Musini, VM	1
Gueyffier, F	1
Puil, L	1
Salzwedel, DM	1
Wright, JM	1
Carmona, MJ	2
Pereira, VA	2
Malbouisson, LM	2
Auler, JO	2
Santos, SR	2
Cruickshank, JM	1
ROWLANDS, DJ	1
HOWITT, G	1
MARKMAN, P	1
Shim, SS	1
Kim, Y	1
Lim, SM	1
Bertoline, MA	1
Omosako, CE	1
Le Bihan, KB	1
Gao, J	1
Fu, W	1
Jin, Z	1
Yu, X	1
Renner, C	1