propranolol has been researched along with Complications, Labor in 12 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The administration of 160 mg of propranolol during pregnancy, labor, and delivery was associated with profound hypoglycemia and respiratory depression in a newborn infant." | 7.65 | Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition. ( Cottrill, CM; Gettes, L; McAllister, RG; Noonan, JA, 1977) |
| "The administration of 160 mg of propranolol during pregnancy, labor, and delivery was associated with profound hypoglycemia and respiratory depression in a newborn infant." | 3.65 | Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition. ( Cottrill, CM; Gettes, L; McAllister, RG; Noonan, JA, 1977) |
| "Autonomic hyperreflexia is a serious peripartum complication associated with spinal cord lesions." | 1.27 | Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion. ( Gimovsky, ML; Ojeda, A; Ozaki, R; Zerne, S, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pergialiotis, V | 1 |
| Frountzas, M | 1 |
| Prodromidou, A | 1 |
| Prapa, S | 1 |
| Perrea, DN | 1 |
| Vlachos, GD | 1 |
| Duda, IV | 1 |
| Gerasimovich, GI | 1 |
| Balakleevskiĭ, AI | 1 |
| Buechler, AA | 1 |
| Palmer, SK | 1 |
| Adamsons, K | 1 |
| de la Vega, A | 1 |
| Santiago, P | 1 |
| Serup, J | 1 |
| Mitrani, A | 1 |
| Oettinger, M | 1 |
| Abinader, EG | 1 |
| Sharf, M | 1 |
| Klein, A | 1 |
| Katz, M | 1 |
| Sokal, MM | 1 |
| Lilling, M | 1 |
| Cottrill, CM | 1 |
| McAllister, RG | 1 |
| Gettes, L | 1 |
| Noonan, JA | 1 |
| Anderson, KE | 1 |
| Bengtsson, LP | 1 |
| Gustafson, I | 1 |
| Ingemarsson, I | 1 |
| Ostheimer, GW | 1 |
| Alper, MH | 1 |
| Gimovsky, ML | 1 |
| Ojeda, A | 1 |
| Ozaki, R | 1 |
| Zerne, S | 1 |
| Barnes, AB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients: a Double-blind Randomized Controlled Trial[NCT03348683] | Phase 2 | 240 participants (Actual) | Interventional | 2017-12-11 | Completed | ||
| Propranolol for Prolonged Labor: A Randomized Controlled Trial (PRO-Labor Trial)[NCT04741698] | Phase 1 | 80 participants (Actual) | Interventional | 2021-07-27 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time of latent labor defined as <6cm of cervical dilation. (NCT03348683)
Timeframe: average of 24 hours
| Intervention | hours (Mean) |
|---|---|
| Propranolol | 11.0 |
| Placebo | 11.2 |
Count of fetus with fetal bradycardia (<110bpm for >10 minutes within 30 minutes of study drug administration) (NCT03348683)
Timeframe: 30 minutes from drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 1 |
| Placebo | 0 |
Count of fetus with fetal heart rate decelerations within 30 minutes of study drug administration (NCT03348683)
Timeframe: 30 minutes from drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 15 |
| Placebo | 13 |
"Neonatal outcome - Number of neonates with hypoglycemia (blood glucose <50).~This population includes only the neonates who had heelsticks to check their blood glucose, which is not a universal practice and was not required by the protocol or IRB. The neonates included were those who met the nursery's risk-based protocol to check blood glucose after birth (ex: infants of diabetic mothers, fetal growth restriction, macrosomia, or symptoms suggestive of hypoglycemia)" (NCT03348683)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 11 |
| Placebo | 8 |
"Composite neonatal outcome score was for any of the following morbidity: Neonatal Intensive Care Unit (NICU) admission, respiratory support (CPAP, nasal cannula, intubation), culture proven sepsis, radiographically proven intracranial hemorrhage, necrotizing enterocolitis, hypoglycemia (for those infants who had sugar checked), and neonatal death.~The composite score was computed as a score of 1 for any indication of neonatal morbidity - neonates who experienced at least one morbidity and the components are given equal weights. Patients who had no evidence of the predefined neonatal morbidities are subsequently given a score of 0. The minimum is 0 and maximum is 1." (NCT03348683)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 21 |
| Placebo | 28 |
"Composite maternal morbidity score consists of a count of postpartum hemorrhage, transfusion, hysterectomy, placental abruption, chorioamnionitis, shoulder dystocia, episiotomy, higher order laceration, and ICU admission.~The composite score was computed as a score of 1 for any indication of maternal morbidity, that is the participant experienced at least one maternal morbidity, and the components are given equal weights. Participants who had no evidence of the predefined maternal morbidities are subsequently given a score of 0. The minimum is 0 and maximum is 1." (NCT03348683)
Timeframe: average of 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 35 |
| Placebo | 49 |
Greater than 500cc of blood expelled during a vaginal delivery or greater than 1000cc of blood expelled during a cesarean section (NCT03348683)
Timeframe: 30 minutes from drug administration
| Intervention | Participants (Count of Participants) |
|---|---|
| Propranolol | 15 |
| Placebo | 26 |
The time of induction (based on time of foley balloon placement for cervical ripening or misoprostol administration) to the time of delivery of the infant. (NCT03348683)
Timeframe: average of 24 hours
| Intervention | hours (Mean) |
|---|---|
| Propranolol | 13.8 |
| Placebo | 14.3 |
Number of various mode of delivery - count of Vaginal delivery, vacuum assisted vaginal delivery, forceps assisted vaginal delivery, cesarean section (NCT03348683)
Timeframe: average of 24 hours
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Spontaneous vaginal delivery | Vacuum assisted vaginal delivery | Forceps assisted vaginal delivery | Cesarean section | |
| Placebo | 61 | 10 | 8 | 40 |
| Propranolol | 64 | 3 | 8 | 46 |
2 reviews available for propranolol and Complications, Labor
| Article | Year |
|---|---|
Propranolol and oxytocin versus oxytocin alone for induction and augmentation of labor: a meta-analysis of randomized trials.
Topics: Cesarean Section; Female; Humans; Infant, Newborn; Labor, Obstetric; Obstetric Labor Complications; | 2016 |
Propranolol and oxytocin versus oxytocin alone for induction and augmentation of labor: a meta-analysis of randomized trials.
Topics: Cesarean Section; Female; Humans; Infant, Newborn; Labor, Obstetric; Obstetric Labor Complications; | 2016 |
Propranolol and oxytocin versus oxytocin alone for induction and augmentation of labor: a meta-analysis of randomized trials.
Topics: Cesarean Section; Female; Humans; Infant, Newborn; Labor, Obstetric; Obstetric Labor Complications; | 2016 |
Propranolol and oxytocin versus oxytocin alone for induction and augmentation of labor: a meta-analysis of randomized trials.
Topics: Cesarean Section; Female; Humans; Infant, Newborn; Labor, Obstetric; Obstetric Labor Complications; | 2016 |
[Thyrotoxicosis in connection with pregnancy and delivery. Review of obstetric, medical and pediatric aspects].
Topics: Antithyroid Agents; Female; Fetal Diseases; Humans; Hyperthyroidism; Infant, Newborn; Infant, Newbor | 1978 |
1 trial available for propranolol and Complications, Labor
| Article | Year |
|---|---|
Reduction in the cesarean section rate in nulliparous patients after administration of intravenous propranolol.
Topics: Adrenergic beta-Antagonists; Adult; Apgar Score; Cesarean Section; Data Interpretation, Statistical; | 1999 |
9 other studies available for propranolol and Complications, Labor
| Article | Year |
|---|---|
[Use of beta adrenoblockaders for stimulating and intensifying labor activity].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Drug Evaluation; Female; Humans; Labor, Induced; Lab | 1981 |
Intrapartum fetal death associated with propranolol; case report and review of physiology.
Topics: Adult; Female; Fetal Death; Fetal Heart; Humans; Obstetric Labor Complications; Pregnancy; Propranol | 1982 |
Use of propranolol in dysfunctional labour.
Topics: Adrenergic beta-Antagonists; Adult; Anxiety; Apgar Score; Birth Weight; Bradycardia; Catecholamines; | 1975 |
An undeliverable fetus with an ominous fetal heart pattern: an obstetric dilemma.
Topics: Adult; Anemia, Sickle Cell; Cesarean Section; Female; Fetal Diseases; Fetal Heart; Fetal Monitoring; | 1979 |
Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition.
Topics: Adult; Apnea; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Matern | 1977 |
The relaxing effect of terbutaline on the human uterus during term labor.
Topics: Abortion, Threatened; Adult; Blood Pressure; Drug Evaluation; Female; Heart Rate; Humans; Infusions, | 1975 |
Intrapartum anesthetic management of the pregnant patient with heart disease.
Topics: Anesthesia, Epidural; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Local; Anesthesia, Ob | 1975 |
Management of autonomic hyperreflexia associated with a low thoracic spinal cord lesion.
Topics: Adult; Autonomic Nervous System Diseases; Cesarean Section; Female; Humans; Hydralazine; Obstetric L | 1985 |
Chronic propranolol administration during pregnancy. A case report.
Topics: Adrenergic beta-Agonists; Female; Fetal Death; Heart Ventricles; Humans; Obstetric Labor Complicatio | 1970 |