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propranolol and Compensatory Hyperinsulinemia

propranolol has been researched along with Compensatory Hyperinsulinemia in 23 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.

Research Excerpts

ExcerptRelevanceReference
" The current study was undertaken to investigate whether sympathetic nervous system and l-arginine-nitric oxide pathway activities are linked to insulin resistance in rats under chronic low salt intake."7.73Insulin resistance due to chronic salt restriction is corrected by alpha and beta blockade and by L-arginine. ( Catanozi, S; do Nascimento, CA; Dolnikoff, MS; Furukawa, LN; Heimann, JC; Leandro, SM; Quintão, EC; Rocha, JC; Ruivo, GF, 2006)
"Carvedilol treatment reversed thyroxin induced hypertriglyceridemia, whereas propranolol treatment had no effect."5.34Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study. ( Bhatt, P; Goyal, R; Makwana, D; Santani, D, 2007)
" The current study was undertaken to investigate whether sympathetic nervous system and l-arginine-nitric oxide pathway activities are linked to insulin resistance in rats under chronic low salt intake."3.73Insulin resistance due to chronic salt restriction is corrected by alpha and beta blockade and by L-arginine. ( Catanozi, S; do Nascimento, CA; Dolnikoff, MS; Furukawa, LN; Heimann, JC; Leandro, SM; Quintão, EC; Rocha, JC; Ruivo, GF, 2006)
" This resulted in hyperinsulinaemia and moderate hypoglycaemia, the latter probably counteracted by overeating and increased glucagon secretion, as indicated by increased body weight and lower liver glycogen contents, respectively."3.69The effects of long-term hyperinsulinaemia on insulin sensitivity in rats. ( Björntorp, P; Holmäng, A; Jennische, E, 1995)
"Carvedilol treatment reversed thyroxin induced hypertriglyceridemia, whereas propranolol treatment had no effect."1.34Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study. ( Bhatt, P; Goyal, R; Makwana, D; Santani, D, 2007)
"This resulted in hyperinsulinemia and moderate hypoglycemia, the latter probably counteracted by overeating and increased glucagon secretion, as indicated by increased body weight and lower liver glycogen contents, respectively."1.29Effects of hyperinsulinemia on muscle fiber composition and capitalization in rats. ( Björntorp, P; Brzezinska, Z; Holmäng, A, 1993)
"Propranolol was used to inhibit elevated adrenergic activity."1.29Rapid formation of capillary endothelial cells in rat skeletal muscle after exposure to insulin. ( Björntorp, P; Holmäng, A; Jennische, E, 1996)
"Moreover, the hyperinsulinemia is mediated in part by prostaglandins just like the well-studied febrile response."1.28Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics. ( Cornell, RP, 1989)
"Extreme hyperinsulinism was observed in endotoxin-shock dogs made hyperglycemic by glucose infusion."1.26Hyperinsulinism in endotoxin shock dogs. ( Anderson, JH; Blackard, WG; Spitzer, JJ, 1976)
"It also corrected the basal hyperinsulinemia as well as the increased insulin secretion which results from stimulation with glucose or arginine."1.25Prevention of hypoglycemic attacks by propranolol in a patient suffering from insulinoma. ( Atsmon, A; Blum, I; Doron, M; Laron, Z; Tiqva, P, 1975)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199012 (52.17)18.7374
1990's5 (21.74)18.2507
2000's5 (21.74)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thompson, EL1
Ray, CJ1
Holmes, AP1
Pye, RL1
Wyatt, CN1
Coney, AM1
Kumar, P1
Ruivo, GF1
Leandro, SM1
do Nascimento, CA1
Catanozi, S1
Rocha, JC1
Furukawa, LN1
Dolnikoff, MS1
Quintão, EC1
Heimann, JC1
Tsai, SY1
Lee, HC1
Chen, CC1
Bhatt, P1
Makwana, D1
Santani, D1
Goyal, R1
Acheson, K1
Jéquier, E1
Wahren, J1
Inoue, S1
Mullen, YS1
Bray, GA1
Holmäng, A3
Jennische, E2
Björntorp, P3
Brzezinska, Z1
Keen, HL1
Brands, MW1
Alonso-Galicia, M1
Hall, JE1
Van De Borne, P1
Hausberg, M1
Hoffman, RP2
Mark, AL1
Anderson, EA1
Rashid, S1
Shi, ZQ1
Niwa, M1
Mathoo, JM1
Vandelangeryt, ML1
Bilinski, D1
Lewis, GF1
Vranic, M1
Sinkey, CA1
Dopp, JM1
Phillips, BG1
Blum, I1
Doron, M1
Laron, Z1
Atsmon, A1
Tiqva, P1
Scandellari, C1
Zaccaria, M1
Sicolo, N1
Casara, D1
Erle, G1
Federspil, G1
Eisner, M1
Spychalska-Szymańska, T1
Stachowski, A1
Hepp, KD1
Blackard, WG1
Anderson, JH1
Spitzer, JJ1
Cornell, RP1
James, DE1
Burleigh, KM1
Kraegen, EW1
Appleyard, WJ1
Lloyd, J1
Kaneto, A1
Tasaka, Y1
Kosaka, K1
Nakao, K1
Byers, SO1
Friedman, M1

Reviews

1 review available for propranolol and Compensatory Hyperinsulinemia

ArticleYear
Studies on the mechanism of insulin action: basic concepts and clinical implications.
    Diabetologia, 1977, Volume: 13, Issue:3

    Topics: Adenylyl Cyclases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Calcium; Cell Membrane; Cyc

1977

Trials

1 trial available for propranolol and Compensatory Hyperinsulinemia

ArticleYear
Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects.
    Diabetes, 2002, Volume: 51, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Arteries; Blood Flow Velocity; Blo

2002

Other Studies

21 other studies available for propranolol and Compensatory Hyperinsulinemia

ArticleYear
Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body.
    The Journal of physiology, 2016, 08-01, Volume: 594, Issue:15

    Topics: Adrenergic beta-Antagonists; Animals; Calcium; Carbon Dioxide; Carotid Body; Epinephrine; Hyperinsul

2016
Insulin resistance due to chronic salt restriction is corrected by alpha and beta blockade and by L-arginine.
    Physiology & behavior, 2006, Jul-30, Volume: 88, Issue:4-5

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Arginine; Blood Pressure; Diet;

2006
Hyperinsulinaemia associated with beta-adrenoceptor antagonist in medicated bipolar patients during manic episode.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, Jun-30, Volume: 31, Issue:5

    Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Bipolar Disorder; Body Mass Index; Female; Humans

2007
Comparative effectiveness of carvedilol and propranolol on glycemic control and insulin resistance associated with L-thyroxin-induced hyperthyroidism--an experimental study.
    Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:5

    Topics: Adrenergic beta-Antagonists; Animals; Appetite; Blood Glucose; Blood Pressure; Body Mass Index; Body

2007
Influence of beta-adrenergic blockade on glucose-induced thermogenesis in man.
    The Journal of clinical investigation, 1983, Volume: 72, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Basal Metabolism; Body Temperature Regulation; Energy Metabolism

1983
Hyperinsulinemia in rats with hypothalamic obesity: effects of autonomic drugs and glucose.
    The American journal of physiology, 1983, Volume: 245, Issue:3

    Topics: Animals; Atropine; Epinephrine; Female; Glucose; Hyperinsulinism; Isoproterenol; Obesity; Phentolami

1983
The effects of long-term hyperinsulinaemia on insulin sensitivity in rats.
    Acta physiologica Scandinavica, 1995, Volume: 153, Issue:1

    Topics: Animals; Blood Glucose; Body Weight; Deoxyglucose; Female; Glycogen; Hyperinsulinism; Insulin; Muscl

1995
Effects of hyperinsulinemia on muscle fiber composition and capitalization in rats.
    Diabetes, 1993, Volume: 42, Issue:7

    Topics: Adipose Tissue; Adrenalectomy; Analysis of Variance; Animals; Blood Glucose; Capillaries; Deoxygluco

1993
Rapid formation of capillary endothelial cells in rat skeletal muscle after exposure to insulin.
    Diabetologia, 1996, Volume: 39, Issue:2

    Topics: Adrenalectomy; Animals; Blood Glucose; Body Weight; Capillaries; Cell Division; Corticosterone; Endo

1996
Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats.
    American journal of hypertension, 1996, Volume: 9, Issue:12 Pt 1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Blood Pressure; D

1996
Hyperinsulinemia produces cardiac vagal withdrawal and nonuniform sympathetic activation in normal subjects.
    The American journal of physiology, 1999, Volume: 276, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Female; Glucose Clamp Technique; Heart Conduction System; Heart

1999
Beta-blockade, but not normoglycemia or hyperinsulinemia, markedly diminishes stress-induced hyperglycemia in diabetic dogs.
    Diabetes, 2000, Volume: 49, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Blood Glucose; Carbachol; Diabetes Mellitus, Experimental; Dog

2000
Prevention of hypoglycemic attacks by propranolol in a patient suffering from insulinoma.
    Diabetes, 1975, Volume: 24, Issue:6

    Topics: Adenoma, Islet Cell; Arginine; Female; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia

1975
Medical treatment of endogenous organic hyperinsulinism.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1976, Volume: Suppl 6

    Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Child; Chlorpromazine; Diazoxide; Female; Humans; Hyperin

1976
[Treatment of organic hyperinsulinism with propranolol in the course of insulinoma].
    Endokrynologia Polska, 1977, Volume: 28, Issue:1

    Topics: Adenoma, Islet Cell; Aged; Female; Humans; Hyperinsulinism; Pancreatic Neoplasms; Propranolol

1977
Hyperinsulinism in endotoxin shock dogs.
    Metabolism: clinical and experimental, 1976, Volume: 25, Issue:6

    Topics: Alloxan; Animals; Blood Glucose; Dogs; Escherichia coli; Glucose; Hyperinsulinism; Islets of Langerh

1976
Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 2

    Topics: Acetophenones; Adrenocorticotropic Hormone; Animals; Atropine; Autonomic Nervous System; Body Temper

1989
In vivo glucose metabolism in individual tissues of the rat. Interaction between epinephrine and insulin.
    The Journal of biological chemistry, 1986, May-15, Volume: 261, Issue:14

    Topics: Animals; Blood Glucose; Deoxyglucose; Drug Interactions; Epinephrine; Glycogen; Hyperinsulinism; Ins

1986
Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.
    Proceedings of the Royal Society of Medicine, 1968, Dec-12, Volume: 61, Issue:12

    Topics: Blood Glucose; Blood Pressure; Cardiomegaly; Child; Diazoxide; Female; Hirsutism; Humans; Hypercalce

1968
Stimulation of insulin secretion by the C-terminal tetrapeptide amide of gastrin.
    Endocrinology, 1969, Volume: 84, Issue:5

    Topics: Animals; Atropine; Dogs; Epinephrine; Femoral Artery; Gastrins; Hyperinsulinism; Injections, Intramu

1969
Insulin hypoglycemia enhanced by beta adrenergic blockade.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1966, Volume: 122, Issue:1

    Topics: Animals; Drug Synergism; Hyperinsulinism; Hypoglycemia; Propranolol; Rats; Sympatholytics

1966