propranolol has been researched along with Cirrhoses, Experimental Liver in 29 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was conducted to investigate any protective effect of early propranolol administration in the development and degree of esophageal varices in cirrhotic rats with portal hypertension." | 7.75 | Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats. ( Alatsakis, M; Ballas, KD; Marakis, GN; Pavlidis, TE; Psarras, K; Rafailidis, S; Sakantamis, AK; Tzioufa-Asimakopoulou, V, 2009) |
| " This study was conducted to investigate any protective effect of early propranolol administration in the development and degree of esophageal varices in cirrhotic rats with portal hypertension." | 3.75 | Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats. ( Alatsakis, M; Ballas, KD; Marakis, GN; Pavlidis, TE; Psarras, K; Rafailidis, S; Sakantamis, AK; Tzioufa-Asimakopoulou, V, 2009) |
| "This study was designed to determine the relationship of propranolol pharmacokinetic parameters with portosystemic shunt in CCl4-induced cirrhotic rats." | 1.31 | [Relationship of propranolol pharmacokinetic parameters with portosystemic shunt in CCl4-induced cirrhotic rats]. ( Choi, HS; Choi, YY; Hahm, JS; Kang, JS; Kim, DU; Kim, JB; Kim, JM; Koh, DH; Lee, MH; Lee, SH; Park, GT; Yun, YS, 2002) |
| " Our aim was to study the hemodynamic effects of the early and chronic administration of PR and spironolactone (SPN), alone or in combination, in a model of hepatic fibrosis and sinusoidal portal hypertension induced in rats by bile duct ligation." | 1.30 | Prevention of portal hypertension by propranolol and spironolactone in rats with bile duct ligation. ( Calès, P; Douay, O; Gallois, Y; Le Jeune, JJ; Maïga, MY; Oberti, F; Pilette, C; Rifflet, H; Saumet, JL, 1997) |
| "Antipyrine extraction was decreased by 90% in acute liver injury, compared with 33% in cirrhosis, suggesting a much greater reduction of microsomal enzyme activity in the former group." | 1.29 | Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat. ( Fenyves, D; Gariépy, L; Villeneuve, JP, 1993) |
| "Propranolol clearance was measured at steady state in 5 normal and 5 cirrhotic weight-matched perfused rat livers under single-pass conditions with normal oxygen delivery (mean, 71." | 1.29 | Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver. ( Angus, PW; Choo, EF; Hickey, PL; McLean, AJ; Morgan, DJ, 1996) |
| "Propranolol-treated rats had significantly lower cardiac output (-31%) and heart rate (-26%) than controls (p less than 0." | 1.28 | Propranolol decreases portal pressure without changing portocollateral resistance in cirrhotic rats. ( Bosch, J; de Lacy, AM; Kravetz, D; Pizcueta, MP; Rodés, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.69) | 18.7374 |
| 1990's | 13 (44.83) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Kawy, HS | 1 |
| Rodríguez, S | 1 |
| Raurell, I | 1 |
| Ezkurdia, N | 1 |
| Augustin, S | 1 |
| Esteban, R | 1 |
| Genescà, J | 1 |
| Martell, M | 1 |
| Alatsakis, M | 2 |
| Ballas, KD | 1 |
| Pavlidis, TE | 1 |
| Psarras, K | 2 |
| Rafailidis, S | 2 |
| Tzioufa-Asimakopoulou, V | 2 |
| Marakis, GN | 1 |
| Sakantamis, AK | 1 |
| Demertzidis, C | 1 |
| Ballas, K | 1 |
| Symeonidis, N | 1 |
| Pavlidis, T | 1 |
| Sakadamis, A | 1 |
| D'Amico, M | 1 |
| Mejías, M | 1 |
| García-Pras, E | 1 |
| Abraldes, JG | 1 |
| García-Pagán, JC | 1 |
| Fernández, M | 1 |
| Bosch, J | 2 |
| Reboredo, M | 1 |
| Chang, HC | 1 |
| Barbero, R | 1 |
| Rodríguez-Ortigosa, CM | 1 |
| Pérez-Vizcaíno, F | 1 |
| Morán, A | 1 |
| García, M | 1 |
| Banales, JM | 1 |
| Carreño, N | 1 |
| Alegre, F | 1 |
| Herrero, I | 1 |
| Quiroga, J | 1 |
| Prieto, J | 1 |
| Sangro, B | 1 |
| Koh, DH | 1 |
| Park, GT | 1 |
| Kim, JM | 1 |
| Yun, YS | 1 |
| Lee, SH | 1 |
| Kim, DU | 1 |
| Kim, JB | 1 |
| Choi, YY | 1 |
| Kang, JS | 1 |
| Choi, HS | 1 |
| Hahm, JS | 1 |
| Lee, MH | 1 |
| Chan, CC | 1 |
| Chang, CC | 1 |
| Huang, HC | 1 |
| Wang, SS | 1 |
| Lee, FY | 1 |
| Chang, FY | 1 |
| Lin, HC | 1 |
| Tai, CC | 1 |
| Lee, SD | 1 |
| Aller, MA | 1 |
| Arias, J | 1 |
| Cardoso, JE | 1 |
| Giroux, L | 2 |
| Kassissia, I | 2 |
| Houssin, D | 1 |
| Habib, N | 1 |
| Huet, PM | 2 |
| Gariépy, L | 3 |
| Fenyves, D | 3 |
| Villeneuve, JP | 5 |
| Lebrec, D | 2 |
| Moreau, R | 1 |
| Cailmail, S | 1 |
| Sogni, P | 1 |
| Oberti, F | 2 |
| Hadengue, A | 1 |
| Hickey, PL | 1 |
| McLean, AJ | 2 |
| Angus, PW | 2 |
| Choo, EF | 2 |
| Morgan, DJ | 2 |
| Hori, N | 1 |
| Okanoue, T | 1 |
| Sawa, Y | 1 |
| Mori, T | 1 |
| Kashima, K | 1 |
| Rifflet, H | 1 |
| Maïga, MY | 1 |
| Pilette, C | 1 |
| Gallois, Y | 1 |
| Douay, O | 1 |
| Le Jeune, JJ | 1 |
| Saumet, JL | 1 |
| Calès, P | 1 |
| Hadoke, PW | 1 |
| Le Couteur, DG | 1 |
| Hickey, H | 1 |
| Harvey, PJ | 1 |
| Gready, J | 1 |
| Pérez-Paramo, M | 1 |
| Muñoz, J | 1 |
| Albillos, A | 1 |
| Freile, I | 1 |
| Portero, F | 1 |
| Santos, M | 1 |
| Ortiz-Berrocal, J | 1 |
| Wood, AJ | 2 |
| Branch, RA | 2 |
| Rogers, LW | 1 |
| Shand, DG | 2 |
| Levy, M | 1 |
| Rogers, L | 1 |
| Pomier-Layrargues, G | 1 |
| Rocheleau, B | 1 |
| Altmann, O | 1 |
| Petit, JL | 1 |
| Raymond, G | 1 |
| Pizcueta, MP | 1 |
| de Lacy, AM | 1 |
| Kravetz, D | 1 |
| Rodés, J | 1 |
| Roulot, D | 1 |
| Gaudin, C | 1 |
| Braillon, A | 1 |
| Sekiyama, T | 1 |
| Bacq, Y | 1 |
| Jirón, MI | 1 |
| Mella, JG | 1 |
| Mánquez, P | 1 |
| Kauer, G | 1 |
| Wolff, C | 1 |
| Jabsa, Z | 1 |
| Soto, JR | 1 |
| Armas-Merino, R | 1 |
29 other studies available for propranolol and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferas | 2021 |
The renal effects of droxidopa are maintained in propranolol treated cirrhotic rats.
Topics: Adrenergic beta-Antagonists; Animals; Atorvastatin; Bilirubin; Carbazoles; Carvedilol; Creatinine; D | 2015 |
Early propranolol administration does not prevent development of esophageal varices in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Esophageal and Gastric Varices; Hypertension, Portal; Liver Cirrhosis | 2009 |
Effect of early propranolol administration on portal hypertensive gastropathy in cirrhotic rats.
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Hypertension, Portal; Liver Cirrhosis, Experimental | 2009 |
Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats.
Topics: Animals; Antihypertensive Agents; Benzenesulfonates; Drug Therapy, Combination; Hypertension, Portal | 2012 |
Zolmitriptan: a novel portal hypotensive agent which synergizes with propranolol in lowering portal pressure.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Body Weight; Carbon Tetrachloride; Ca | 2013 |
[Relationship of propranolol pharmacokinetic parameters with portosystemic shunt in CCl4-induced cirrhotic rats].
Topics: Animals; Carbon Tetrachloride Poisoning; Chromatography, High Pressure Liquid; Liver Cirrhosis, Expe | 2002 |
Effects of norepinephrine and acetylcholine on portal-systemic collaterals of common bile duct-ligated cirrhotic rat.
Topics: Acetylcholine; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertens | 2005 |
Portal systemic collateral development: is it a trophic adaptation mechanism to hepatic deprivation?
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Collateral | 2006 |
Liver function improvement following increased portal blood flow in cirrhotic rats.
Topics: Animals; Cell Survival; In Vitro Techniques; Indicator Dilution Techniques; Liver; Liver Circulation | 1994 |
Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique.
Topics: Animals; Chlorpromazine; In Vitro Techniques; Indicator Dilution Techniques; Liver; Liver Cirrhosis, | 1993 |
Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat.
Topics: Animals; Antipyrine; Carbon Tetrachloride; Chlorpromazine; In Vitro Techniques; Liver; Liver Circula | 1993 |
Effects of terlipressin on hemodynamics and oxygen content in conscious portal vein stenosed and cirrhotic rats receiving propranolol.
Topics: Animals; Blood Pressure; Carbon Dioxide; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Hyper | 1993 |
Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver.
Topics: Adrenergic beta-Antagonists; Animals; Cytochrome P-450 Enzyme System; Liver; Liver Cirrhosis, Experi | 1996 |
Haemodynamic effects of combined treatment with molsidomine and propranolol on portal hypertension in conscious and unrestrained cirrhotic rats.
Topics: Animals; Drug Therapy, Combination; Hemodynamics; Hypertension, Portal; Liver Cirrhosis, Experimenta | 1996 |
Prevention of portal hypertension by propranolol and spironolactone in rats with bile duct ligation.
Topics: Animals; Antihypertensive Agents; Cholestasis; Drug Evaluation, Preclinical; Drug Therapy, Combinati | 1997 |
Effect of propranolol on vascular hyporesponsiveness in cirrhosis.
Topics: Animals; Humans; Liver Cirrhosis, Experimental; Muscle, Smooth, Vascular; Propranolol; Rats; Vasodil | 1997 |
Effect of cirrhosis on sulphation by the isolated perfused rat liver.
Topics: Animals; Liver; Liver Cirrhosis, Experimental; Male; Nitrophenols; Oxidation-Reduction; Perfusion; P | 1999 |
Hepatic artery flow and propranolol metabolism in perfused cirrhotic rat liver.
Topics: Animals; Body Weight; Hepatic Artery; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Male; | 1999 |
Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites.
Topics: Animals; Bacteria; Bacterial Translocation; Carbon Tetrachloride; Intestinal Absorption; Intestines; | 2000 |
Intact hepatocyte theory of impaired drug metabolism in experimental cirrhosis in the rat.
Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Liver; Liver Circulation; Liver Cirrhosis, Experiment | 1979 |
Sodium retention in dogs with cirrhosis and ascites: efferent mechanisms.
Topics: Aldosterone; Animals; Ascites; Blood Pressure; Cardiac Output; Denervation; Dogs; Estrogens; Female; | 1977 |
Impaired drug metabolism in experimental cirrhosis in the rat.
Topics: Aminopyrine; Animals; Half-Life; Hexobarbital; Kinetics; Liver; Liver Cirrhosis, Experimental; Male; | 1978 |
Combined treatment of portal hypertension with ritanserin and propranolol in conscious and unrestrained cirrhotic rats.
Topics: Animals; Consciousness; Drug Therapy, Combination; Hemodynamics; Hypertension, Portal; Liver Cirrhos | 1992 |
[Pharmacological lowering of portal pressure in normal rats and in experimental liver cirrhosis].
Topics: Acute Disease; Animals; Blood Pressure; Canrenoic Acid; Heart Rate; Hypertension, Portal; Liver Cirr | 1991 |
Propranolol metabolism by isolated hepatocytes from normal and cirrhotic rat livers: the effect of albumin.
Topics: Albumins; Animals; Carbon Tetrachloride; Cell Survival; Liver; Liver Cirrhosis, Experimental; Male; | 1990 |
Propranolol decreases portal pressure without changing portocollateral resistance in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Cardiac Output; Collateral Circulation; Heart Rate; L | 1989 |
Hemodynamic effects of a combination of clonidine and propranolol in conscious cirrhotic rats.
Topics: Animals; Clonidine; Drug Synergism; Hemodynamics; Liver Circulation; Liver Cirrhosis, Experimental; | 1989 |
[Effect of propranolol on intrahepatic portal hypertension in the rat].
Topics: Animals; Blood Pressure; Carbon Tetrachloride Poisoning; Female; Heart Rate; Hypertension, Portal; L | 1987 |