Compounds > propranolol
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propranolol and Chemical and Drug Induced Liver Injury

propranolol has been researched along with Chemical and Drug Induced Liver Injury in 34 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Research Excerpts

ExcerptRelevanceReference
"We report the case of a patient who developed jaundice, encephalopathy, a marked increase in serum aminotransferase activity and a decrease in prothrombin and proaccelerin levels, after 6 weeks' treatment with carbimazole and propranolol for hyperthyroidism."3.69Fulminant hepatitis after carbimazole and propranolol administration. ( Banc, P; Coste, V; Epeirier, JM; Larrey, D; Michel, H; Pageaux, GP; Perrigault, PF, 1996)
"Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported."3.67[The so-called dihydralazine hepatitis. A contribution to the pathogenesis]. ( Jahn, G; Krombholz, B; Machnik, G; Reinhardt, M, 1985)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"Propranolol was without effect on blood glucose level."1.28Metoprolol and propranolol treatment in carbon tetrachloride-induced hepatic injury. ( Kulcsár, A; Kulcsár-Gergely, J, 1992)
"Propranolol pretreatment (30 min prior to phalloidin injection) did not afford protection against hepatotoxicity, but increased alkaline phosphatase, 5'-nucleotidase and aminotransferase activities."1.26Phalloidin hepatotoxicity in rats in vivo. Effect of a sympatholytic agent: propranolol. ( Claude, JR; Jacqueson, A; Thevenin, M; Warnet, JM, 1981)
"Reserpine was uneffective in terms of liver derangement, but exerted some protection against the general toxic effect of A."1.25Effects of sympatholytic agents on amanita phalloides toxicity in the rat. ( Baccino, FM; Pernigotti, L; Torrielli, MV; Zuretti, MF, 1975)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199015 (44.12)18.7374
1990's4 (11.76)18.2507
2000's1 (2.94)29.6817
2010's12 (35.29)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Dawson, S1
Stahl, S2
Paul, N1
Barber, J1
Kenna, JG2
Ding, D1
Kelly, R1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Warner, DJ1
Chen, H1
Cantin, LD1
Walker, CL1
Noeske, T1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Abrar, H1
Arsalan, A1
Yasin, H1
Zaidi, SIH1
Ibrahim, S1
Qadeer, K1
Naeem, H1
Fatima, K1
Tabassum, H1
Naqvi, SNH1
Okwara, CJ1
Mojtahed, A1
Gavin, M1
Hanson, J1
McCarthy, D1
Abdel-Kawy, HS1
TSOLAKAS, TC1
DAVIES, JP1
ORAM, S1
GRANT, RH1
GREEN, KG1
KERNOHAN, RJ1
NEELY, RA1
Varela, JA1
Jacobs, MB1
Thevenin, M1
Warnet, JM1
Jacqueson, A1
Claude, JR1
Epeirier, JM1
Pageaux, GP1
Coste, V1
Perrigault, PF1
Banc, P1
Larrey, D1
Michel, H1
Lee, SP1
Tasman-Jones, C1
Wattie, WJ1
Zuretti, MF1
Pernigotti, L1
Torrielli, MV1
Baccino, FM1
Kulcsár-Gergely, J1
Kulcsár, A1
Sugihara, N1
Furuno, K1
Kita, N1
Murakami, T1
Yata, N1
Ochi, Y1
Yumori, Y1
Morioka, A1
Miura, K1
Tsukamoto, I1
Kojo, S1
Chindavijak, B1
Belpaire, FM1
Bogaert, MG1
Kunze, KD2
Porst, H2
Tschöpel, L2
Lohmann, J1
Reinhardt, M1
Machnik, G1
Krombholz, B1
Jahn, G1
Rosner, I1
Romero-Ferret, C1
Mottot, G1
Auty, RM1
Branch, RA1
Szlamka, I1
Kovách, AG1
Somogyi, J1
Menyhárt, J1
Prodanov, A1
Popnikolov, S1
Talakov, A1
Slaviiska, V1

Reviews

1 review available for propranolol and Chemical and Drug Induced Liver Injury

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016

Other Studies

33 other studies available for propranolol and Chemical and Drug Induced Liver Injury

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
The novel effect of propranolol in glibenclamide induced hepatotoxicity.
    Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:4(Suppleme

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bili

2020
Jaundice: A Thyroid Problem?
    Digestive diseases and sciences, 2017, Volume: 62, Issue:8

    Topics: Adrenergic beta-Antagonists; Anti-Bacterial Agents; Biopsy; Chemical and Drug Induced Liver Injury;

2017
Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
    Drug and chemical toxicology, 2021, Volume: 44, Issue:1

    Topics: Acetaminophen; Adrenergic beta-Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferas

2021
PROPRANOLOL IN ATTEMPTED MAINTENANCE OF SINUS RHYTHM AFTER ELECTRICAL DEFIBRILLATION.
    Lancet (London, England), 1964, Nov-14, Volume: 2, Issue:7368

    Topics: Atrial Fibrillation; Chemical and Drug Induced Liver Injury; Electric Countershock; Hepatitis; Human

1964
PROPRANOLOL.
    Lancet (London, England), 1964, Dec-05, Volume: 2, Issue:7371

    Topics: Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Hepatitis; Propranolol; Sympath

1964
SERUM-TRANSAMINASE LEVELS IN PATIENTS TREATED WITH PROPRANOLOL.
    Lancet (London, England), 1964, Dec-19, Volume: 2, Issue:7373

    Topics: Alanine Transaminase; Angina Pectoris; Aspartate Aminotransferases; Biomedical Research; Chemical an

1964
[Rapid preoperative preparation with iopanoic acid in severe liver toxicity due to methimazole: anesthetic implications].
    Revista espanola de anestesiologia y reanimacion, 2008, Volume: 55, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Anesthesia, Intravenous; Antithyroid Agents; Chemical and Drug I

2008
Hepatic infarction related to oral contraceptive use.
    Archives of internal medicine, 1984, Volume: 144, Issue:3

    Topics: Adult; Aortography; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Female; Hepatic Ar

1984
Phalloidin hepatotoxicity in rats in vivo. Effect of a sympatholytic agent: propranolol.
    Toxicology letters, 1981, Volume: 7, Issue:6

    Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Lipid Metabolism; Liver;

1981
Fulminant hepatitis after carbimazole and propranolol administration.
    European journal of gastroenterology & hepatology, 1996, Volume: 8, Issue:3

    Topics: Adrenergic beta-Antagonists; Alanine Transaminase; Antithyroid Agents; Aspartate Aminotransferases;

1996
Traumatic hemobilia: a complication of percutaneous liver biopsy.
    Gastroenterology, 1977, Volume: 72, Issue:5 Pt 1

    Topics: Adult; Alcoholism; Bile; Biliary Tract Diseases; Biopsy, Needle; Blood; Chemical and Drug Induced Li

1977
Effects of sympatholytic agents on amanita phalloides toxicity in the rat.
    Research communications in chemical pathology and pharmacology, 1975, Volume: 10, Issue:3

    Topics: Acid Phosphatase; Animals; Butoxamine; Catecholamines; Chemical and Drug Induced Liver Injury; Epine

1975
Metoprolol and propranolol treatment in carbon tetrachloride-induced hepatic injury.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:10

    Topics: Aminopyrine N-Demethylase; Animals; Bilirubin; Blood Glucose; Carbon Tetrachloride Poisoning; Chemic

1992
Increase in the plasma protein binding of weakly basic drugs in carbon tetrachloride-intoxicated rats.
    Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:10

    Topics: Animals; Blood Proteins; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Mal

1991
Effect of alpha-blockade on liver regeneration after carbon tetrachloride intoxication in the rat.
    Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12

    Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury;

1990
In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation.
    The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:11

    Topics: Aminopyrine N-Demethylase; Animals; Antipyrine; Biotransformation; Chemical and Drug Induced Liver I

1987
[Morphology and pathogenesis of liver injury produced by dihydralazine , propranolol and ketophenylbutazone].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1985, Volume: 130, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Dihydralazine; Humans; Hydralazine; Immunity, Cellular; Live

1985
[Liver lesions induced by dihydralazine and propranolol].
    Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1985, Volume: 130, Issue:1

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Dihydralazine; Female; Humans; Hydralaz

1985
[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1985, Volume: 45, Issue:6

    Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Dihydralazine; Drug Therapy, Combinatio

1985
Letter: Treatment of acute paracetamol poisoning.
    Lancet (London, England), 1973, Dec-01, Volume: 2, Issue:7840

    Topics: Acetaminophen; Alprenolol; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationsh

1973
Letter: Paracetamol toxicity and propranolol.
    Lancet (London, England), 1973, Dec-29, Volume: 2, Issue:7844

    Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Dogs; Drug Antago

1973
Effect of beta receptor blockade on liver injury induced by carbon tetrachloride.
    Acta physiologica Academiae Scientiarum Hungaricae, 1973, Volume: 43, Issue:3

    Topics: Acid Phosphatase; Adipose Tissue; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced

1973
[Liver disorders in Inderal therapy].
    Vutreshni bolesti, 1972, Volume: 11, Issue:5

    Topics: Aged; Arrhythmias, Cardiac; Autopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver;

1972