Page last updated: 2024-11-03

propranolol and Cancer of Nose

propranolol has been researched along with Cancer of Nose in 13 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Research Excerpts

Excerpt	Relevance	Reference
"Propranolol therapy is changing the treatment paradigm for infantile hemangioma."	9.19	Propranolol therapy for reducing the number of nasal infantile hemangioma invasive procedures. ( Chen, BS; Manning, SC; Parikh, SR; Perkins, JA; Saltzman, B, 2014)
"To evaluate the response of nasal tip hemangiomas to systemic propranolol."	7.78	Hemangiomas of the nasal tip treated with propranolol. ( Ben-Amitai, D; Halachmi, S; Kalish, E; Lapidoth, M; Raveh, E; Zvulunov, A, 2012)
"In 2008, propranolol was serendipitously observed to cause accelerated involution of infantile haemangioma."	7.77	Low-dose propranolol for infantile haemangioma. ( Itinteang, T; Leadbitter, P; Tan, ST, 2011)
"Propranolol therapy is changing the treatment paradigm for infantile hemangioma."	5.19	Propranolol therapy for reducing the number of nasal infantile hemangioma invasive procedures. ( Chen, BS; Manning, SC; Parikh, SR; Perkins, JA; Saltzman, B, 2014)
"To evaluate the response of nasal tip hemangiomas to systemic propranolol."	3.78	Hemangiomas of the nasal tip treated with propranolol. ( Ben-Amitai, D; Halachmi, S; Kalish, E; Lapidoth, M; Raveh, E; Zvulunov, A, 2012)
"In 2008, propranolol was serendipitously observed to cause accelerated involution of infantile haemangioma."	3.77	Low-dose propranolol for infantile haemangioma. ( Itinteang, T; Leadbitter, P; Tan, ST, 2011)
"Oral propranolol is now the treatment of choice in many situations."	1.39	Ulcerated nasal infantile haemangioma treated by oral propranolol. ( Al Dosari, S; Riad, H, 2013)

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (7.69)	29.6817
2010's	12 (92.31)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Keller, RG	1
Stevens, S	1
Hochman, M	1
Daguzé, J	1
Saint-Jean, M	1
Dréno, B	1
Dalby, TK	1
Lester-Smith, D	1
Ben-Amitai, D	1
Halachmi, S	1
Zvulunov, A	1
Raveh, E	1
Kalish, E	1
Lapidoth, M	1
Al Dosari, S	1
Riad, H	1
Perkins, JA	1
Chen, BS	1
Saltzman, B	1
Manning, SC	1
Parikh, SR	1
Li, L	1
Ma, L	1
Vergine, G	1
Sorci, M	1
Rosafio, C	1
Bigucci, B	1
Filippini, B	1
Ancora, G	1
Léauté-Labrèze, C	1
Dumas de la Roque, E	1
Hubiche, T	1
Boralevi, F	1
Thambo, JB	1
Taïeb, A	1
Tan, ST	1
Itinteang, T	1
Leadbitter, P	1
Eivazi, B	1
Cremer, HJ	1
Mangold, C	1
Teymoortash, A	1
Wiegand, S	1
Werner, JA	1
Mishra, A	1
Holmes, WJM	1
Liew, S	1
Williams, K	1
Woolf, R	1
Morrison, D	1

Clinical Trials (10)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Propanolol Effect on Red Cell Adhesion in Non-Asthmatic Children With Sickle Cell Disease: A Dose Finding Study[NCT02012777]	Phase 1	9 participants (Actual)	Interventional	2010-06-30	Terminated (stopped due to Inability to recruit patients into the study.)
A Randomised, Controlled, Multidose, Multicentre, Adaptive Phase II/III Study in Infants With Proliferating Infantile Hemangiomas (IHs) Requiring Systemic Therapy to Compare 4 Regimens of Propranolol (1 or 3 mg/kg/Day for 3 or 6 Months) to Placebo (Double[NCT01056341]	Phase 2/Phase 3	512 participants (Actual)	Interventional	2010-01-31	Completed
Propranolol vs Prednisolone for Infant Hemangiomas-A Clinical and Molecular Study[NCT00967226]	Phase 2	19 participants (Actual)	Interventional	2009-07-31	Terminated (stopped due to Serious adverse events with prednisolone, primarily temporary growth retardation, <5th percentile.)
Melablock: A Multicentre Randomized, Double---blinded and Placebo---controlled Clinical Trial on the Efficacy and Safety of Once Daily Propranolol 80 mg Retard for the Prevention of Cutaneous Malignant Melanoma Recurrence[NCT02962947]	Phase 2/Phase 3	546 participants (Anticipated)	Interventional	2017-06-30	Not yet recruiting
"'' Efficacy of Propranolol in the Treatment of Infantile Hemangioma"[NCT04684667]	Phase 2	100 participants (Anticipated)	Interventional	2021-01-01	Not yet recruiting
Phase 2 Study of Sildenafil for the Treatment of Lymphatic Malformations[NCT02335242]	Phase 2	22 participants (Actual)	Interventional	2015-05-23	Completed
A Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Proliferative and Involuting Cutaneous Infantile Hemangioma[NCT01072045]	Phase 2	50 participants (Actual)	Interventional	2010-01-31	Completed
A Modular Open Label, Signal Seeking, Phase II Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations (TARGET-VM)[NCT05983159]	Phase 2	30 participants (Anticipated)	Interventional	2023-09-30	Not yet recruiting
Double Blind, Randomised, Placebo-controlled Study of Propranolol in Infantile Capillary Hemangiomas[NCT00744185]	Phase 2/Phase 3	14 participants (Actual)	Interventional	2008-10-31	Terminated (stopped due to Study halted prematurely due to some difficulties in recruitment of patients)
Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol[NCT01533376]	Phase 1	3 participants (Actual)	Interventional	2012-02-29	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Interim Analysis : Complete/Nearly Complete Resolution of the Target Infantile Hemangioma at Week 24 Compared to Baseline Based on the Intra-patient Blinded Centralized Independent Qualitative Assessments of Week 24 Photographs.

(NCT01056341)
Timeframe: 6 months

Intervention	percentage of participants (Number)
Placebo	8.0
Propranolol 1mg/kg/d 3 Months	9.8
Propranolol 1 mg/kg/d 6 Months	37.5
Propranolol 3 mg/kg/d 3 Months	7.7
Propranolol 3 mg/kg/d 6 Months	62.8

Primary Analysis : Complete/Nearly Complete Resolution of the Target Infantile Hemangioma at W24 Compared to Baseline Based on the Intra-patient Blinded Centralized Independent Qualitative Assessments of W24 Photographs.

(NCT01056341)
Timeframe: 6 months

Intervention	percentage of participants (Number)
Placebo	3.6
Propranolol 3mg/kg/d 6 Months	60.4

Allergy/Immunology Adverse Events

Number of allergy/immunology AE per study arm (NCT00967226)
Timeframe: enrollment through study closeout or study withdrawal up to 9 months

Intervention	Adverse Events (Number)
Allergy/Immunology Events Propranolol	1
Allergy/Immunology Events Prednisolone	1

Constitutional Adverse Events

Number of constitutional AEs in each study arm. (NCT00967226)
Timeframe: enrollment to study close out or withdrawal up to 9 months

Intervention	Adverse Events (Number)
Constitutional AEs Propranolol	2
Constitutional AEs Prednisolone	3

Decrease in Size of Hemangioma (Length x Width) in Square mm

A priori primary outcome was proportional change in the total surface area as measured by lesion's outer margin length x width at baseline minus the same measure at 4 months with surrogate data used at 5 months if 4 months not available. (NCT00967226)
Timeframe: 4-5 months after initiating therapy

Intervention	mm squared (Mean)
Propranolol	0.57
Prednisolone	0.63

Dermatologic Adverse Events

Number of Dermatologic Adverse Events in each study arm. (NCT00967226)
Timeframe: enrollment to study close out or withdrawal up to 9 months

Intervention	Adverse Events (Number)
Dermatologic AEs Propranolol	2
Dermatologic AEs Prednisolone	1

Endocrinologic Adverse Events

Number of Endocrinologic AEs (of which adrenal crisis does not overlap). (NCT00967226)
Timeframe: enrollment to close out or study withdrawal up to 9 months

Intervention	Adverse Events (Number)
Endocrine AEs Propranolol	0
Endocrinologic AEs Prednisolone	7

Gastrointestinal Adverse Events

Number of Gastrointestinal AEs in each arm (NCT00967226)
Timeframe: enrollment to study withdrawal or study close out up to 9 months

Intervention	Adverse Events (Number)
Gastrointestinal AEs Propranolol	6
Gastrointestinal AEs Prednisolone	6

Growth and Development Adverse Events

Number of Growth and Development AEs in each study arm (NCT00967226)
Timeframe: enrollment to study withdrawal or close out up to 9 months

Intervention	Adverse Events (Number)
Growth/Developoment AEs Propranolol	0
Growth/Development AEs Prednisolone	1

Infectious Adverse Events

Number of infectious AEs in each study arm (i.e. conjunctivitis, thrush, fever) (NCT00967226)
Timeframe: enrollment to study withdrawal or close out up to 9 months

Intervention	Adverse Events (Number)
Infectious AEs Propranolol	5
Infectious AEs Prednisolone	3

Metabolic or Laboratory AEs

Number of Metabolic or Laboratory AEs in each study arm. (NCT00967226)
Timeframe: enrollment to study withdrawal or close out up to 9 months

Intervention	Adverse Events (Number)
Metabolic/Laboratory AEs Propranolol	1
Metabolic/Laboratory AEs Prednisolone	0

Number of Serious Adverse Events (SAEs)

Number of serious adverse events experienced by the participants in each treatment arm within the categories adrenal crisis, growth/development, constitutional. Serious adverse events are defined as events that result in death, require either inpatient hospitalization or the prolongation of hospitalization, are life-threatening, result in a persistent or significant disability/incapacity, or result in a congenital anomaly/birth defect. Other important medical events, based upon appropriate medical judgment, may also be considered Serious Adverse Events if a trial participant's health is at risk and intervention is required to prevent an outcome mentioned. (NCT00967226)
Timeframe: enrollment until study close out or withdrawal up to 9 months

Intervention	Serious Adverse Events (Number)
Number of Serious Adverse Events in Propranolol	1
Number of Serious Adverse Events in Prednisolone	11

Pulmonary/Respiratory Adverse Events

Number of pulmonary/respiratory adverse events (CTCAE 22) in each study arm (NCT00967226)
Timeframe: enrollment through study close out or withdrawal, up to 9 months

Intervention	Adverse Events (Number)
Pulmonary/Respiratory AEs Propranolol	14
Pulmonary/Respiratory AEs Prednisolone	4

Vascular Adverse Events

Number of Vascular AEs in each study arm. (NCT00967226)
Timeframe: enrollment to study withdrawal or close out up to 9 months

Intervention	Adverse Events (Number)
Vascular AEs Propranolol	3
Vascular AEs Prednisolone	4

Tolerability of Medication

All adverse events relating to medication tolerability including: adrenal crisis, growth/development, constitutional (dehydration), allergy/immunology, dermatologic, endocrine, GI, infection, metabolism/labs, pulmonary, vascular. (NCT00967226)
Timeframe: enrollment until study close out or withdrawal up to 9 months

Intervention	Events (Number)
	Adverse Events	Serious Adverse Events
Overall Number of Adverse Events in Prednisolone	30	11
Overall Number of Adverse Events in Propranolol	34	1

Change in Lesion Volume of the Test Medication as Evaluated by MRI Examination.

Participants will be followed for the duration of the study, an expected average of 20 weeks. (NCT02335242)
Timeframe: Baseline, week 20

Intervention	percentage of volume (Mean)
Double-Blind Placebo	5.89
Open-Label Sildenafil	-8.54
Double-blind Sildenafil	-0.642

Change in Subject's Assessment of Change in Lymphatic Malformation Overall Score

"Subject's evaluation of the overall change in lymphatic malformation. Participants will be followed from baseline to 20 weeks.~Patients rated change as no improvement, minimal improvement (1-25% change), fair improvement (25-50% change), good improvement (50-75% change), and excellent improvement (75-100% change)." (NCT02335242)
Timeframe: Baseline, week 20

Intervention	Participants (Count of Participants)
	No improvement	Minimal improvement	Fair improvement	Good improvement	Excellent improvement
Double-Blind Placebo	1	2	0	2	0
Double-Blind Sildenafil	2	4	1	1	0

Reviews

2 reviews available for propranolol and Cancer of Nose

Article	Year
Propranolol for the treatment of infantile haemangioma. Journal of paediatrics and child health, 2013, Volume: 49, Issue:2 Topics: Hemangioma, Capillary; Humans; Infant; Nose Neoplasms; Propranolol; Randomized Controlled Trials as	2013
"Cyrano nose" associated with hepatic hemangiomas successfully treated with propranolol. Dermatology online journal, 2015, Jul-15, Volume: 21, Issue:7 Topics: Adrenergic beta-Antagonists; Female; Follow-Up Studies; Hemangioma; Humans; Infant; Liver Neoplasms;	2015

Trials

1 trial available for propranolol and Cancer of Nose

Article	Year
Propranolol therapy for reducing the number of nasal infantile hemangioma invasive procedures. JAMA otolaryngology-- head & neck surgery, 2014, Volume: 140, Issue:3 Topics: Adolescent; Adrenergic beta-Antagonists; Child; Child, Preschool; Female; Hemangioma; Humans; Laser	2014

Other Studies

10 other studies available for propranolol and Cancer of Nose

Article	Year
Modern Management of Nasal Hemangiomas. JAMA facial plastic surgery, 2017, Jul-01, Volume: 19, Issue:4 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Algorithms; Child; Child, Preschool; Combined Modality T	2017
Large nose angiosarcoma treated effectively with oral cyclophosphamide combined with propranolol. Journal of the European Academy of Dermatology and Venereology : JEADV, 2018, Volume: 32, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Hemangiosarcoma; Humans; Male; Mid	2018
Hemangiomas of the nasal tip treated with propranolol. Dermatology (Basel, Switzerland), 2012, Volume: 225, Issue:4 Topics: Administration, Oral; Adrenergic beta-Antagonists; Female; Hemangioma; Humans; Infant; Israel; Male;	2012
Ulcerated nasal infantile haemangioma treated by oral propranolol. Dermatology online journal, 2013, May-15, Volume: 19, Issue:5 Topics: Administration, Oral; Drug Administration Schedule; Female; Hemangioma, Capillary; Humans; Infant; N	2013
Use of propranolol on a nasal hemangioma in an extremely low birthweight premature infant. The Journal of dermatology, 2015, Volume: 42, Issue:11 Topics: Child, Preschool; Hemangioma; Humans; Infant; Infant, Extremely Low Birth Weight; Infant, Extremely	2015
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Propranolol for severe hemangiomas of infancy. The New England journal of medicine, 2008, Jun-12, Volume: 358, Issue:24 Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Facial Neoplasms; Glucocorticoids; Hemangiom	2008
Low-dose propranolol for infantile haemangioma. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2011, Volume: 64, Issue:3 Topics: Administration, Oral; Adrenergic beta-Antagonists; Breast Neoplasms; Ear Neoplasms; Female; Follow-U	2011
Hemangiomas of the nasal tip: an approach to a therapeutic challenge. International journal of pediatric otorhinolaryngology, 2011, Volume: 75, Issue:3 Topics: Adrenergic beta-Antagonists; Child, Preschool; Cicatrix; Cryotherapy; Esthetics; Female; Follow-Up S	2011
The Cyrano nose: different treatment approaches to management of hemangiomas of the nasal tip. Plastic and reconstructive surgery, 2011, Volume: 127, Issue:6 Topics: Hemangioma; Humans; Infant; Nose Neoplasms; Propranolol; Rhinoplasty	2011
Periocular lesion in an infant. BMJ (Clinical research ed.), 2011, Nov-28, Volume: 343 Topics: Adrenergic beta-Antagonists; Eyelid Neoplasms; Female; Hemangioma, Capillary; Humans; Infant; Laser	2011