propranolol has been researched along with Burns in 75 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined whether acute propranolol treatment prevented posttraumatic stress disorder (PTSD), anxiety, and depression in children hospitalized in the pediatric intensive care unit for large burns." | 9.27 | Does Acute Propranolol Treatment Prevent Posttraumatic Stress Disorder, Anxiety, and Depression in Children with Burns? ( Herndon, DN; Holzer, CE; Humphries, HF; Meyer, WJ; Rosenberg, L; Rosenberg, M; Sharp, S; Thomas, CR, 2018) |
| " In intention-to-treat and per-protocol analyses, patients randomized to propranolol had worse pain scores on study days 5 to 19." | 9.20 | Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. ( Bangdiwala, SI; Bortsov, AV; Cairns, BA; Haith, LR; Halawa, OI; Holmes, JH; Hoskins, JM; Hwang, J; Jones, SW; Jordan, MH; McLean, SA; Orrey, DC; Platts-Mills, TF; Roane, BR; Shupp, JW, 2015) |
| "rhGH in combination with propranolol attenuates hypermetabolism and inflammation without the adverse side effects found with rhGH therapy alone." | 9.13 | Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children. ( Finnerty, CC; Herndon, DN; Jeschke, MG; Kulp, GA; Mlcak, RP; Przkora, R, 2008) |
| "Propranolol treatment attenuates hypermetabolism and does not cause increased incidence of infection and sepsis." | 9.12 | Propranolol does not increase inflammation, sepsis, or infectious episodes in severely burned children. ( Branski, LK; Finnerty, CC; Herndon, DN; Jeschke, MG; Norbury, WB, 2007) |
| "At present, beta-adrenergic blockade with propranolol represents probably the most efficacious anticatabolic therapy in the treatment of burns." | 8.87 | Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs? ( Gauglitz, GG; Herndon, DN; Jeschke, MG; Williams, FN, 2011) |
| "In this phase II randomized controlled trial, patients with burns ≥20% of total body surface area were randomly assigned to control or propranolol (dose given to decrease heart rate <100 bpm)." | 5.69 | Propranolol Normalizes Metabolomic Signatures Thereby Improving Outcomes After Burn. ( Abdullahi, A; Auger, C; de Brito Monteiro, L; Jeschke, MG; Knuth, CM; Rehou, S; Stanojcic, M, 2023) |
| "Faster healing of the superficial burns was noticed in the patients of propranolol group." | 5.34 | Effects of Propranolol in Accelerating Wound Healing and Attenuation of Hypermetabolism in Adult Burn Patients. ( Ahmed, UT; Cheema, SA; Dogar, SR; Mustafa, Z; Nasir, H, 2020) |
| "This study examined whether acute propranolol treatment prevented posttraumatic stress disorder (PTSD), anxiety, and depression in children hospitalized in the pediatric intensive care unit for large burns." | 5.27 | Does Acute Propranolol Treatment Prevent Posttraumatic Stress Disorder, Anxiety, and Depression in Children with Burns? ( Herndon, DN; Holzer, CE; Humphries, HF; Meyer, WJ; Rosenberg, L; Rosenberg, M; Sharp, S; Thomas, CR, 2018) |
| " In intention-to-treat and per-protocol analyses, patients randomized to propranolol had worse pain scores on study days 5 to 19." | 5.20 | Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. ( Bangdiwala, SI; Bortsov, AV; Cairns, BA; Haith, LR; Halawa, OI; Holmes, JH; Hoskins, JM; Hwang, J; Jones, SW; Jordan, MH; McLean, SA; Orrey, DC; Platts-Mills, TF; Roane, BR; Shupp, JW, 2015) |
| "One-hundred seventy-nine pediatric patients with more than 30% total body surface area burns were randomized to control (n = 89) or 4 mg/kg/d propranolol (n = 90) for 12 months postburn." | 5.16 | Long-term propranolol use in severely burned pediatric patients: a randomized controlled study. ( Barrow, RE; Diaz, EC; Finnerty, CC; Hegde, S; Herndon, DN; Jennings, K; Jeschke, MG; Lee, JO; Meyer, W; Mlcak, RP; Rodriguez, NA; Suman, OE; Suri, JS; Williams, FN, 2012) |
| "rhGH in combination with propranolol attenuates hypermetabolism and inflammation without the adverse side effects found with rhGH therapy alone." | 5.13 | Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children. ( Finnerty, CC; Herndon, DN; Jeschke, MG; Kulp, GA; Mlcak, RP; Przkora, R, 2008) |
| "Propranolol treatment attenuates hypermetabolism and does not cause increased incidence of infection and sepsis." | 5.12 | Propranolol does not increase inflammation, sepsis, or infectious episodes in severely burned children. ( Branski, LK; Finnerty, CC; Herndon, DN; Jeschke, MG; Norbury, WB, 2007) |
| "Fifty-six children with more than 40% TBSA burns were randomized to one of four anabolic regimens: untreated control, GH treatment, propranolol treatment, or combination GH plus propranolol therapy." | 5.10 | Beta-blockade and growth hormone after burn. ( Chinkes, DL; Hart, DW; Herndon, DN; Lal, SO; Ramzy, PI; Wolf, SE, 2002) |
| "In children with burns, treatment with propranolol during hospitalization attenuates hypermetabolism and reverses muscle-protein catabolism." | 5.09 | Reversal of catabolism by beta-blockade after severe burns. ( Chinkes, DL; Hart, DW; Herndon, DN; Wolf, SE; Wolfe, RR, 2001) |
| "A PubMed search was conducted using the terms "burns", "thermal injury", "beta-blocker" and "propranolol", with the filters "human" and "English" and "Spanish"." | 4.91 | Systematic review of the effect of propanolol on hypermetabolism in burn injuries. ( García-de-Lorenzo, A; Millán, P; Núñez-Villaveirán, T; Sánchez, M, 2015) |
| "Data support the efficacy of testosterone, oxandrolone, human recombinant growth hormone, insulin, metformin, and propranolol in improving skeletal muscle protein net balance in patients with severe burns." | 4.91 | Effects of pharmacological interventions on muscle protein synthesis and breakdown in recovery from burns. ( Børsheim, E; Diaz, EC; Herndon, DN; Porter, C; Sidossis, LS; Suman, OE, 2015) |
| "At present, beta-adrenergic blockade with propranolol represents probably the most efficacious anticatabolic therapy in the treatment of burns." | 4.87 | Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs? ( Gauglitz, GG; Herndon, DN; Jeschke, MG; Williams, FN, 2011) |
| "Propranolol can aggravate injury to the liver, kidney and intestine at early stage in rat with severe burn, suggesting that "shock heart" may be one of initial factors in lowering blood flow to the organs, thus inducing injury to them." | 3.75 | [Influence of myocardial inhibition on injury to liver, kidney and intestine at early stage in rat with severe scald]. ( Huang, YS; Lei, ZY; Xiao, R, 2009) |
| "Ninety-eight children, 2 to 18 years of age, with burns covering more than 40% of their body surface and who received either propranolol (beta-adrenergic blockade) or placebo were studied." | 3.73 | The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly. ( Barrow, LN; Barrow, RE; Dasu, MR; Herndon, DN; Wolfe, RR, 2006) |
| "To quantify the various components of splanchnic free fatty acid and very-low-density lipoprotein-triacylglycerol (VLDL-TAG) metabolism in order to gain insight into the mechanisms responsible for the development of fatty liver in severely burned patients, and to determine if decreasing free fatty acid availability by use of propranolol could potentially reduce hepatic fatty acid accumulation." | 3.71 | Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate diet. ( Herndon, DN; Irtun, O; Morio, B; Wolfe, RR, 2002) |
| "For severely burned adults, propranolol was safe and effective on reducing energy expenditure, limited hepatomegaly, and accelerated partial burn wound and donor site closure, but does not affect length of stay in ICU, hospitalization, complication ormortality rate." | 3.11 | The use of propranolol in adult burn patients: Safety and outcome influence. ( An, NH; Khanh, PQ; Lam, NN, 2022) |
| "Heart rate can be decreased to a similar degree with Q6 and Q24 dosing strategies, with the Q8 dosing strategy being less effective." | 2.84 | Propranolol kinetics in plasma from severely burned adults. ( Andersen, CR; Edgu-Fry, E; Finnerty, CC; Guillory, AN; Herndon, DN; Silva, MB; Suman, OE, 2017) |
| "Propranolol was administered within 48 hours of burns and given throughout hospital discharge to decrease heart rate by approximately 20% from admission levels." | 2.80 | Propranolol attenuates hemorrhage and accelerates wound healing in severely burned adults. ( Ali, A; Andersen, CR; Brewer, JL; Finnerty, CC; Grogans, RJ; Hasan, S; Heffernan, J; Herndon, DN; Lee, JO; Mamachen, A; Suman, OE, 2015) |
| "Propranolol-treated adults had a decrease in requirements of blood transfusions (MD -185." | 2.55 | Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis. ( Ferrada, P; Foianini, JE; García-Perdomo, HA; Gomez, DA; Manzano-Nunez, R; Ordoñez Delgado, CA, 2017) |
| " Occurrence of adverse events was not significantly different between the treated patients the and controls." | 2.53 | The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis. ( Flores, O; Muller, MJ; Paratz, JD; Roberts, JA; Stockton, K, 2016) |
| "Propranolol has shown to be effective in treating the hypermetabolic state secondary to a major burn injury." | 1.48 | The Safety and Efficacy of Propranolol in Reducing the Hypermetabolic Response in the Pediatric Burn Population. ( Andersen, CR; Blumenthal, E; Herndon, DN; Meyer, WJ; Ojeda, S; Robles, L; Stevens, P, 2018) |
| "Propranolol was felt to improve outcomes in 56% of responses while 39% were "unsure"." | 1.46 | A survey of the use of propranolol in burn centers: Who, what, when, why. ( Kahn, SA; LeCompte, MT; Rae, L, 2017) |
| "Propranolol was not found to influence the risk for subsequent ASD." | 1.36 | Propranolol does not reduce risk for acute stress disorder in pediatric burn trauma. ( Meyer, W; Rosenberg, L; Rosenberg, M; Sharp, S; Thomas, C, 2010) |
| "Propranolol hydrochloride was injected in 1 group during the tracer infusion to decrease heart rate, and the other group without propranolol injection served as a control." | 1.35 | Acute propranolol infusion stimulates protein synthesis in rabbit skin wound. ( Aarsland, A; Chinkes, DL; Finnerty, CC; Herndon, DN; Jeschke, MG; Meng, C; Zhang, XJ, 2009) |
| "All propranolol-treated animals presented more than 70 percent of reepithelialized wound area 63 days after burning, whereas control animals did not." | 1.35 | Low-dose propranolol improves cutaneous wound healing of burn-injured rats. ( Monte-Alto-Costa, A; Nascimento, AP; Romana-Souza, B, 2008) |
| "Propranolol pretreatment did not reduce postburn beta-EP and C rises in autotransplanted animals." | 1.28 | Pituitary-adrenal stress response in the absence of brain-pituitary connections. ( Ballantyne, JC; Carr, DB; Kemp, JW; Osgood, PF; Szyfelbein, SK, 1989) |
| "Propranolol was administered to these patients 20 +/- 15 days postburn." | 1.28 | Improved myocardial oxygen utilization following propranolol infusion in adolescents with postburn hypermetabolism. ( Abston, S; Barrow, RE; Desai, M; Herndon, DN; Minifee, PK, 1989) |
| " Variations in drug dosage and feeding regimens will, however, need to be perfected to limit catabolic effects." | 1.27 | Effect of propranolol administration on hemodynamic and metabolic responses of burned pediatric patients. ( Barrow, RE; Herndon, DN; Jahoor, F; Minifee, P; Rutan, TC; Wolfe, RR, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (18.67) | 18.7374 |
| 1990's | 5 (6.67) | 18.2507 |
| 2000's | 17 (22.67) | 29.6817 |
| 2010's | 31 (41.33) | 24.3611 |
| 2020's | 8 (10.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lam, NN | 1 |
| Khanh, PQ | 1 |
| An, NH | 1 |
| Freiha, M | 1 |
| Achim, M | 1 |
| Gheban, BA | 1 |
| Moldovan, R | 1 |
| Filip, GA | 1 |
| Rehou, S | 1 |
| de Brito Monteiro, L | 1 |
| Auger, C | 2 |
| Knuth, CM | 2 |
| Abdullahi, A | 1 |
| Stanojcic, M | 1 |
| Jeschke, MG | 12 |
| Gus, EI | 1 |
| Shahrokhi, S | 1 |
| Cheema, SA | 1 |
| Ahmed, UT | 1 |
| Nasir, H | 1 |
| Dogar, SR | 1 |
| Mustafa, Z | 1 |
| Hassoun-Kheir, N | 1 |
| Henig, O | 1 |
| Avni, T | 1 |
| Leibovici, L | 1 |
| Paul, M | 1 |
| Walczak, J | 1 |
| Bunn, C | 1 |
| Saini, P | 1 |
| Liu, YM | 1 |
| Baldea, AJ | 1 |
| Muthumalaiappan, K | 3 |
| Hasan, S | 3 |
| Mosier, MJ | 2 |
| Conrad, P | 1 |
| Szilagyi, A | 2 |
| Gamelli, RL | 2 |
| Guillory, AN | 1 |
| Herndon, DN | 37 |
| Silva, MB | 1 |
| Andersen, CR | 5 |
| Edgu-Fry, E | 1 |
| Suman, OE | 11 |
| Finnerty, CC | 14 |
| Rivas, E | 2 |
| McEntire, SJ | 2 |
| Chao, T | 1 |
| Porter, C | 2 |
| Siopi, A | 1 |
| Ideker, H | 1 |
| Mlcak, RP | 5 |
| Sidossis, LS | 2 |
| Rosenberg, L | 2 |
| Rosenberg, M | 2 |
| Sharp, S | 2 |
| Thomas, CR | 1 |
| Humphries, HF | 1 |
| Holzer, CE | 1 |
| Meyer, WJ | 4 |
| El Ayadi, A | 1 |
| Prasai, A | 2 |
| Wang, Y | 1 |
| Ojeda, S | 1 |
| Blumenthal, E | 1 |
| Stevens, P | 1 |
| Robles, L | 1 |
| Herndon, D | 1 |
| Capek, KD | 2 |
| Ross, E | 1 |
| Jay, JW | 1 |
| Ayadi, AE | 1 |
| Foncerrada-Ortega, G | 1 |
| Blears, E | 1 |
| Sommerhalder, C | 1 |
| McMullen, K | 1 |
| Amtmann, D | 1 |
| Cox, R | 1 |
| Hundeshagen, G | 2 |
| Jennings, K | 2 |
| Sousse, LE | 2 |
| Orrey, DC | 1 |
| Halawa, OI | 1 |
| Bortsov, AV | 1 |
| Shupp, JW | 1 |
| Jones, SW | 1 |
| Haith, LR | 1 |
| Hoskins, JM | 1 |
| Jordan, MH | 1 |
| Bangdiwala, SI | 1 |
| Roane, BR | 1 |
| Platts-Mills, TF | 1 |
| Holmes, JH | 1 |
| Hwang, J | 1 |
| Cairns, BA | 1 |
| McLean, SA | 1 |
| Núñez-Villaveirán, T | 1 |
| Sánchez, M | 1 |
| Millán, P | 1 |
| García-de-Lorenzo, A | 1 |
| Diaz, EC | 2 |
| Børsheim, E | 1 |
| Ali, A | 1 |
| Mamachen, A | 1 |
| Grogans, RJ | 1 |
| Brewer, JL | 1 |
| Lee, JO | 2 |
| Heffernan, J | 1 |
| Li, H | 1 |
| Yin, J | 1 |
| Zhang, Z | 1 |
| Winston, JH | 1 |
| Shi, XZ | 1 |
| Chen, JD | 1 |
| Flores, O | 1 |
| Stockton, K | 1 |
| Roberts, JA | 1 |
| Muller, MJ | 1 |
| Paratz, JD | 1 |
| Martinez, R | 1 |
| Rogers, A | 1 |
| Numanoglu, A | 1 |
| Rode, H | 1 |
| Wurzer, P | 2 |
| Branski, LK | 2 |
| Clayton, RP | 1 |
| Forbes, AA | 1 |
| Voigt, CD | 2 |
| Kamolz, LP | 1 |
| Woodson, LC | 1 |
| Guillory, A | 1 |
| Kline, A | 1 |
| Klein, GL | 1 |
| Tompkins, RG | 1 |
| LeCompte, MT | 1 |
| Rae, L | 1 |
| Kahn, SA | 1 |
| Manzano-Nunez, R | 1 |
| García-Perdomo, HA | 1 |
| Ferrada, P | 1 |
| Ordoñez Delgado, CA | 1 |
| Gomez, DA | 1 |
| Foianini, JE | 1 |
| Romana-Souza, B | 1 |
| Nascimento, AP | 1 |
| Monte-Alto-Costa, A | 1 |
| Zhang, XJ | 1 |
| Meng, C | 1 |
| Chinkes, DL | 3 |
| Aarsland, A | 2 |
| Yiga, JB | 1 |
| Xiao, R | 1 |
| Huang, YS | 1 |
| Lei, ZY | 1 |
| Thomas, C | 1 |
| Meyer, W | 2 |
| Williams, FN | 3 |
| Kulp, GA | 2 |
| Gauglitz, GG | 1 |
| Kobayashi, M | 1 |
| Asai, A | 1 |
| Kogiso, M | 1 |
| Yoshida, S | 1 |
| Suzuki, F | 1 |
| Oláh, G | 1 |
| Sbrana, E | 1 |
| Elijah, I | 1 |
| Gerö, D | 1 |
| Szabó, C | 1 |
| Brooks, NC | 1 |
| Song, J | 1 |
| Boehning, D | 1 |
| Kraft, R | 1 |
| Rodriguez, NA | 1 |
| Hegde, S | 1 |
| Suri, JS | 1 |
| Barrow, RE | 8 |
| Porro, LJ | 1 |
| Al-Mousawi, AM | 1 |
| Williams, F | 1 |
| Rojas, Y | 1 |
| Radhakrishnan, RS | 1 |
| Morio, B | 1 |
| Irtun, O | 1 |
| Wolfe, RR | 11 |
| Hart, DW | 2 |
| Wolf, SE | 2 |
| Lal, SO | 1 |
| Ramzy, PI | 1 |
| Dasu, MR | 2 |
| Neudeck, BL | 1 |
| Foster, DR | 1 |
| Li, LY | 1 |
| Gonzales, JP | 1 |
| Welage, LS | 1 |
| Pereira, CT | 2 |
| Barrow, LN | 1 |
| Norbury, WB | 1 |
| Przkora, R | 1 |
| Kehlet, H | 1 |
| Durkot, MJ | 1 |
| Nguyen, TT | 1 |
| Maggi, SP | 1 |
| Biolo, G | 1 |
| Muller, M | 1 |
| Chinkes, D | 1 |
| Nelson, SO | 1 |
| Pierre, E | 1 |
| Jiang, M | 1 |
| Li, S | 1 |
| Zhang, Y | 1 |
| Kawakami, M | 1 |
| He, J | 1 |
| Sakamoto, T | 1 |
| Okada, Y | 1 |
| Sheridan, RL | 1 |
| Maykel, JA | 1 |
| Pazirandeh, S | 1 |
| Bistrian, BR | 1 |
| Hilton, JG | 1 |
| Wells, CH | 1 |
| Markley, K | 1 |
| Smallman, ET | 1 |
| Briggs, LW | 1 |
| Gore, DC | 1 |
| Honeycutt, D | 1 |
| Jahoor, F | 4 |
| Breitenstein, E | 1 |
| Chioléro, RL | 1 |
| Jéquier, E | 1 |
| Dayer, P | 1 |
| Krupp, S | 1 |
| Schutz, Y | 1 |
| Carr, DB | 1 |
| Ballantyne, JC | 1 |
| Osgood, PF | 1 |
| Kemp, JW | 1 |
| Szyfelbein, SK | 1 |
| Yü, CC | 1 |
| Hua, HA | 1 |
| Tong, C | 1 |
| Minifee, PK | 1 |
| Abston, S | 1 |
| Desai, M | 1 |
| Loegering, DJ | 1 |
| Commins, LM | 1 |
| Rutan, TC | 1 |
| Minifee, P | 1 |
| Wood, M | 1 |
| Peters, EJ | 1 |
| Desai, MH | 1 |
| Holland, OB | 1 |
| Miyoshi, H | 1 |
| Wolfe, M | 1 |
| Wilmore, DW | 1 |
| Long, JM | 1 |
| Mason, AD | 1 |
| Skreen, RW | 1 |
| Pruitt, BA | 1 |
| Green, KL | 1 |
| Ginsburg, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Treatment of the Severely Burned With Anabolic Agents on Clinical Outcomes, Recovery and Rehabilitation[NCT00675714] | Phase 2/Phase 3 | 1,126 participants (Actual) | Interventional | 2004-01-31 | Terminated (stopped due to At the request of the study site, this study has been closed and access to study-related data is unavailable. We are unable to submit the results-data.) | ||
| Contribution of COMT Haplotypes in Propranolol Analgesic Efficacy for Treating Post-surgical Pain After Laparoscopic Hemicolectomy[NCT02511483] | Phase 2 | 10 participants (Actual) | Interventional | 2015-05-18 | Terminated (stopped due to Difficulty with recruitment) | ||
| Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU Patients[NCT03678233] | Phase 2 | 30 participants (Anticipated) | Interventional | 2019-06-27 | Recruiting | ||
| Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds: A Randomized Controlled Trial[NCT03452072] | Phase 2/Phase 3 | 88 participants (Actual) | Interventional | 2018-08-20 | Completed | ||
| Multicenter Benchmarking of Functional and Psychosocial Outcomes of Pediatric Burn Survivors[NCT00239668] | 3,000 participants (Anticipated) | Observational | 2000-03-31 | Completed | |||
| Evaluating of Oral Propranolol Effect on Managing Anxiety of Dental Extractions in Children: A Randomized Controlled Clinical Trial[NCT03388957] | 60 participants (Actual) | Interventional | 2018-07-30 | Completed | |||
| Xbox Kinect™ to Promote Physical Fitness and Lean Mass in Severely Burned Children: A Randomized Controlled Trial[NCT04350034] | 40 participants (Actual) | Interventional | 2016-06-15 | Completed | |||
| Randomized, Controlled, Multicenter Study of the Effect of In-Patient Exercise Training on Length of Hospitalization, Mental Health, and Physical Performance in Burned Patients[NCT02739464] | 77 participants (Actual) | Interventional | 2014-09-15 | Completed | |||
| "Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by the Funny Channel Current (If) Inhibitor Ivabradine"[NCT01186783] | Phase 2 | 70 participants (Anticipated) | Interventional | 2010-05-31 | Recruiting | ||
| In Vivo Cellular and Physiological Response to Severe Burns Injuries[NCT03024931] | 10 participants (Anticipated) | Observational | 2017-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for propranolol and Burns
| Article | Year |
|---|---|
Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.
Topics: Anabolic Agents; Burns; Clonidine; Growth Hormone-Releasing Hormone; Hormones; Human Growth Hormone; | 2020 |
The Effect of β-Blockers for Burn Patients on Clinical Outcomes: Systematic Review and Meta-Analysis.
Topics: Adrenergic beta-Antagonists; Adult; Arrhythmias, Cardiac; Burns; Child; Humans; Hypotension; Propran | 2021 |
Burn-induced hypermetabolism and skeletal muscle dysfunction.
Topics: Burns; Cachexia; Epigenesis, Genetic; Exercise; Human Growth Hormone; Humans; Insulin; Metformin; Mu | 2021 |
Is propranolol of benefit in pediatric burn patients?
Topics: Adrenergic beta-Antagonists; Burns; Cardiovascular Diseases; Child; Humans; Propranolol; Randomized | 2013 |
Systematic review of the effect of propanolol on hypermetabolism in burn injuries.
Topics: Adrenergic beta-Antagonists; Adult; Burns; Child; Humans; Propranolol | 2015 |
Effects of pharmacological interventions on muscle protein synthesis and breakdown in recovery from burns.
Topics: Adrenergic beta-Antagonists; Anabolic Agents; Androgens; Body Surface Area; Burns; Human Growth Horm | 2015 |
The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis.
Topics: Adrenergic beta-Antagonists; Burns; Energy Metabolism; Humans; Patient Safety; Propranolol | 2016 |
Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis.
Topics: Adrenergic beta-Antagonists; Burns; Humans; Patient Safety; Propranolol | 2017 |
Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs?
Topics: Anabolic Agents; Blood Glucose; Burns; Growth Hormone; Humans; Insulin; Insulin Resistance; Insulin- | 2011 |
Burns: an update on current pharmacotherapy.
Topics: Adrenergic beta-Antagonists; Anabolic Agents; Animals; Burns; Growth Hormone; Humans; Hypoglycemic A | 2012 |
The pharmacologic modulation of the hypermetabolic response to burns.
Topics: Adrenergic beta-Antagonists; Anabolic Agents; Burns; Catecholamines; Humans; Hypoglycemic Agents; In | 2005 |
Beta-blockade in burns.
Topics: Adrenergic beta-Antagonists; Animals; Burns; Humans; Propranolol | 2007 |
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca | 1986 |
24 trials available for propranolol and Burns
| Article | Year |
|---|---|
The use of propranolol in adult burn patients: Safety and outcome influence.
Topics: Adult; Burns; Hospitalization; Humans; Propranolol; Prospective Studies; Wound Healing | 2022 |
Propranolol Normalizes Metabolomic Signatures Thereby Improving Outcomes After Burn.
Topics: Adipose Tissue; Adrenergic beta-Antagonists; Burns; Humans; Metabolomics; Propranolol | 2023 |
Effects of Propranolol in Accelerating Wound Healing and Attenuation of Hypermetabolism in Adult Burn Patients.
Topics: Adrenergic beta-Antagonists; Adult; Burns; Female; Humans; Length of Stay; Male; Propranolol; Treatm | 2020 |
Propranolol kinetics in plasma from severely burned adults.
Topics: Adrenergic beta-Antagonists; Adult; Arterial Pressure; Blood Pressure; Body Surface Area; Burns; Fem | 2017 |
Resting β-Adrenergic Blockade Does Not Alter Exercise Thermoregulation in Children With Burn Injury: A Randomized Control Trial.
Topics: Adrenergic beta-Antagonists; Body Temperature Regulation; Burns; Case-Control Studies; Child; Double | 2018 |
Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children.
Topics: Adolescent; Basal Metabolism; Body Composition; Burns; Cardiorespiratory Fitness; Child; Exercise Th | 2018 |
Does Acute Propranolol Treatment Prevent Posttraumatic Stress Disorder, Anxiety, and Depression in Children with Burns?
Topics: Adolescent; Adrenergic beta-Antagonists; Anxiety; Burns; Child; Depression; Female; Follow-Up Studie | 2018 |
β-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars.
Topics: Adolescent; Adrenergic beta-Agonists; Biopsy; Burns; Cell Membrane; Cells, Cultured; Child; Child, P | 2018 |
Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol.
Topics: Adolescent; Anabolic Agents; Biomarkers; Biopsy; Burns; Child; Cicatrix, Hypertrophic; Double-Blind | 2018 |
Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.
Topics: Adrenergic beta-Antagonists; Adult; Burn Units; Burns; Catechol O-Methyltransferase; Double-Blind Me | 2015 |
Propranolol attenuates hemorrhage and accelerates wound healing in severely burned adults.
Topics: Adrenergic beta-Antagonists; Adult; Blood Loss, Surgical; Burns; Cohort Studies; Female; Humans; Mal | 2015 |
Propranolol Reduces Cardiac Index But does not Adversely Affect Peripheral Perfusion in Severely Burned Children.
Topics: Adolescent; Arterial Pressure; Burns; Cardiac Output; Child; Child, Preschool; Extravascular Lung Wa | 2016 |
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord | 2016 |
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord | 2016 |
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord | 2016 |
Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children.
Topics: Adolescent; Burns; Child; Child, Preschool; Drug Therapy, Combination; Female; Growth; Growth Disord | 2016 |
β-Adrenergic blockade does not impair the skin blood flow sensitivity to local heating in burned and nonburned skin under neutral and hot environments in children.
Topics: Adolescent; Adrenergic beta-Antagonists; Burns; Child; Double-Blind Method; Heating; Hot Temperature | 2017 |
Propranolol decreases cardiac work in a dose-dependent manner in severely burned children.
Topics: Adolescent; Adrenergic beta-Antagonists; Age Factors; Body Surface Area; Burns; Child; Child, Presch | 2011 |
Long-term propranolol use in severely burned pediatric patients: a randomized controlled study.
Topics: Adolescent; Adrenergic beta-Antagonists; Blood Pressure; Body Composition; Burns; Calorimetry, Indir | 2012 |
Long-term propranolol use in severely burned pediatric patients: a randomized controlled study.
Topics: Adolescent; Adrenergic beta-Antagonists; Blood Pressure; Body Composition; Burns; Calorimetry, Indir | 2012 |
Long-term propranolol use in severely burned pediatric patients: a randomized controlled study.
Topics: Adolescent; Adrenergic beta-Antagonists; Blood Pressure; Body Composition; Burns; Calorimetry, Indir | 2012 |
Long-term propranolol use in severely burned pediatric patients: a randomized controlled study.
Topics: Adolescent; Adrenergic beta-Antagonists; Blood Pressure; Body Composition; Burns; Calorimetry, Indir | 2012 |
Effects of propranolol and exercise training in children with severe burns.
Topics: Absorptiometry, Photon; Administration, Oral; Adolescent; Age Factors; Burns; Child; Double-Blind Me | 2013 |
Beta-blockade and growth hormone after burn.
Topics: Adrenergic beta-Antagonists; Burns; Child; Drug Therapy, Combination; Energy Metabolism; Female; Gro | 2002 |
Gene expression profiles and protein balance in skeletal muscle of burned children after beta-adrenergic blockade.
Topics: Adolescent; Adrenergic beta-Antagonists; Burns; Child; Child, Preschool; Female; Gene Expression Pro | 2003 |
Propranolol does not increase inflammation, sepsis, or infectious episodes in severely burned children.
Topics: Adrenergic beta-Antagonists; Anabolic Agents; Burns; Child; Energy Metabolism; Female; Humans; Infla | 2007 |
Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children.
Topics: Adolescent; Adrenergic beta-Antagonists; Burns; Child; Cytokines; Drug Therapy, Combination; Energy | 2008 |
Lipolysis in burned patients is stimulated by the beta 2-receptor for catecholamines.
Topics: Adolescent; Adult; Blood Urea Nitrogen; Body Surface Area; Burns; Glycerol; Hemodynamics; Humans; Le | 1994 |
Beta-blockade lowers peripheral lipolysis in burn patients receiving growth hormone. Rate of hepatic very low density lipoprotein triglyceride secretion remains unchanged.
Topics: Adolescent; Adrenergic beta-Antagonists; Burns; Calorimetry, Indirect; Child; Child, Preschool; Cros | 1996 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
Reversal of catabolism by beta-blockade after severe burns.
Topics: Adrenergic beta-Antagonists; Body Composition; Burns; Child; Energy Metabolism; Female; Heart Rate; | 2001 |
38 other studies available for propranolol and Burns
| Article | Year |
|---|---|
In Vivo Study of the Effects of Propranolol, Timolol, and Minoxidil on Burn Wound Healing in Wistar Rats.
Topics: Animals; Antioxidants; Burns; Female; Fibrosis; Inflammation; Minoxidil; Necrosis; Propranolol; Rats | 2023 |
Transient Improvement in Erythropoiesis Is Achieved Via the Chaperone AHSP With Early Administration of Propranolol in Burn Patients.
Topics: Adrenergic beta-Antagonists; Blood Proteins; Burns; Erythropoiesis; Humans; Molecular Chaperones; Pr | 2021 |
Terminal Maturation of Orthochromatic Erythroblasts Is Impaired in Burn Patients.
Topics: Adrenergic beta-Antagonists; Adult; Burns; Cell Culture Techniques; Erythroblasts; Erythropoiesis; F | 2018 |
Discrete β-adrenergic mechanisms regulate early and late erythropoiesis in erythropoietin-resistant anemia.
Topics: Adrenergic Antagonists; Anemia; Animals; Burns; Butoxamine; Disease Models, Animal; Erythropoiesis; | 2017 |
The Safety and Efficacy of Propranolol in Reducing the Hypermetabolic Response in the Pediatric Burn Population.
Topics: Adolescent; Adrenergic beta-Antagonists; Burns; Child; Child, Preschool; Female; Humans; Hypertensio | 2018 |
Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats.
Topics: Acupuncture, Ear; Adrenergic beta-Antagonists; Animals; Burns; Cyclooxygenase 2; Electroacupuncture; | 2016 |
Fatal non-occlusive mesenteric ischemia and the use of propranolol in paediatric burns.
Topics: Adrenergic beta-Antagonists; Burns; Child; Fatal Outcome; Female; Humans; Infant; Male; Mesenteric I | 2016 |
A survey of the use of propranolol in burn centers: Who, what, when, why.
Topics: Adrenergic beta-Antagonists; Adult; Ambulatory Care; Attitude of Health Personnel; Body Surface Area | 2017 |
Low-dose propranolol improves cutaneous wound healing of burn-injured rats.
Topics: Adrenergic beta-Antagonists; Animals; Burns; Collagen; Dermatitis; Dose-Response Relationship, Drug; | 2008 |
Acute propranolol infusion stimulates protein synthesis in rabbit skin wound.
Topics: Adrenergic beta-Antagonists; Animals; Burns; Cell Cycle Proteins; Disease Models, Animal; DNA; Drug | 2009 |
Ogilvie's syndrome, beta-blockers and burns.
Topics: Adrenergic beta-Antagonists; Adult; Burns; Colonic Pseudo-Obstruction; Humans; Male; Propranolol | 2009 |
[Influence of myocardial inhibition on injury to liver, kidney and intestine at early stage in rat with severe scald].
Topics: Animals; Blood Pressure; Burns; Intestines; Kidney; Liver; Male; Myocardium; Propranolol; Rats; Rats | 2009 |
Propranolol does not reduce risk for acute stress disorder in pediatric burn trauma.
Topics: Adrenergic beta-Antagonists; Burns; Child; Female; Humans; Male; Propranolol; Risk Factors; Stress D | 2010 |
Propranolol as a modulator of M2b monocytes in severely burned patients.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Antigens, Bacterial; Burns; Catecholamines; Child; C | 2011 |
Increased poly(ADP-ribosyl)ation in skeletal muscle tissue of pediatric patients with severe burn injury: prevention by propranolol treatment.
Topics: Adolescent; Adrenergic beta-Antagonists; Blotting, Western; Burns; Child; Child, Preschool; Female; | 2011 |
Propranolol improves impaired hepatic phosphatidylinositol 3-kinase/akt signaling after burn injury.
Topics: Adrenergic beta-Antagonists; Animals; Burns; Endoplasmic Reticulum Stress; Insulin; Insulin Receptor | 2012 |
Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate diet.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Burns; Child; Child, Preschool; Dietary Carbohydrate | 2002 |
The effects of thermal injury on transcellular permeability and intestinal P-glycoprotein in rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Burns; Carrier Proteins; Immunohis | 2003 |
The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly.
Topics: Adrenergic beta-Antagonists; Burns; Child; Enteral Nutrition; Female; Hepatomegaly; Humans; Male; Pr | 2006 |
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesth | 1984 |
Effects of adrenergic blockade on glucose kinetics in septic and burned guinea pigs.
Topics: Animals; Body Temperature; Burns; Catecholamines; Escherichia coli Infections; Glucagon; Glucose; Gu | 1981 |
[Effects of endogenous beta-adrenoceptor agonist on lung edema in scalded rats].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Bronchoalveolar Lavage Fluid; Burns; | 1997 |
Catecholamines play a role in the production of interleukin-6 and interleukin-1alpha in unburned skin after burn injury in mice.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Burns; Chromatography, High Pres | 2001 |
A great constitutional disturbance.
Topics: Adrenergic beta-Antagonists; Burns; Child; Energy Metabolism; Humans; Muscle Proteins; Propranolol | 2001 |
Beta-blockade and severe burns.
Topics: Adrenergic beta-Antagonists; Burns; Dietary Carbohydrates; Energy Intake; Energy Metabolism; Glycoge | 2002 |
Effects of beta adrenergic blocking agents upon thermal trauma induced cardiovascular changes.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Burns; Butoxamine; Cardiac Output; Dogs; Hemod | 1979 |
Early mortality and temperature regulation in burned mice following administration of catecholamines and adrenergic receptor blocking drugs.
Topics: Animals; Blood Circulation; Body Fluids; Body Temperature Regulation; Burns; Dibenzylchlorethamine; | 1979 |
Propranolol diminishes extremity blood flow in burned patients.
Topics: Adult; Burns; Catecholamines; Energy Metabolism; Fasting; Heart; Hemodynamics; Humans; Indocyanine G | 1991 |
Effects of beta-blockade on energy metabolism following burns.
Topics: Administration, Oral; Adult; Body Weight; Burns; Catecholamines; Energy Metabolism; Female; Heart Ra | 1990 |
Pituitary-adrenal stress response in the absence of brain-pituitary connections.
Topics: Animals; beta-Endorphin; Burns; Corticosterone; Corticotropin-Releasing Hormone; Hypophysectomy; Hyp | 1989 |
Hyperglycaemia after burn injury.
Topics: Adrenalectomy; Animals; Burns; Glucose Tolerance Test; Hyperglycemia; Insulin; Male; Phentolamine; P | 1989 |
Improved myocardial oxygen utilization following propranolol infusion in adolescents with postburn hypermetabolism.
Topics: Adolescent; Adult; Burns; Female; Heart Rate; Humans; Male; Myocardium; Oxygen Consumption; Proprano | 1989 |
Effect of beta-receptor stimulation on Kupffer cell complement receptor clearance function.
Topics: Animals; Burns; Epinephrine; Isoproterenol; Kupffer Cells; Male; Norepinephrine; Propranolol; Rats; | 1988 |
Effect of propranolol administration on hemodynamic and metabolic responses of burned pediatric patients.
Topics: Adolescent; Blood Glucose; Blood Pressure; Burns; Child; Child, Preschool; Energy Metabolism; Fastin | 1988 |
Regulation of lipolysis in severely burned children.
Topics: Adolescent; Burns; Child; Child, Preschool; Energy Metabolism; Epinephrine; Fatty Acids, Nonesterifi | 1987 |
Effect of severe burn injury on substrate cycling by glucose and fatty acids.
Topics: Adolescent; Adult; Body Temperature Regulation; Burns; Child; Child, Preschool; Energy Metabolism; F | 1987 |
Catecholamines: mediator of the hypermetabolic response to thermal injury.
Topics: Adolescent; Adult; Aged; Body Surface Area; Body Temperature; Body Temperature Regulation; Burns; Ca | 1974 |
A pro-inflammatory effect of adrenaline in thermal injury.
Topics: Animals; Blood Circulation; Bradykinin; Burns; Drug Synergism; Duodenum; Edema; Epinephrine; Female; | 1973 |