propranolol has been researched along with Brain Injuries in 32 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propranolol in vivo increased cerebral perfusion and decreased cerebral hypoxia." | 7.75 | The in vivo effect of propranolol on cerebral perfusion and hypoxia after traumatic brain injury. ( Conti, PS; Dagliyan, G; Ley, EJ; Margulies, DR; Park, R; Salim, A; Scehnet, J; Schroff, S, 2009) |
| " The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation." | 7.70 | Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999) |
| " This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha1-NA antagonist, or propranolol (PROP), a beta-NA antagonist, would continue to reinstate hemiplegia over time after recovery from weight-drop traumatic brain injury (TBI)." | 5.31 | Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury. ( Feeney, DM; Stibick, DL, 2001) |
| "The propranolol was continued until all signs of autonomic dysfunction abated." | 5.29 | Fever of central origin in traumatic brain injury controlled with propranolol. ( Meythaler, JM; Stinson, AM, 1994) |
| " We have provided experimental evidence showing the suppressive effects of the nonselective β-adrenoreceptor antagonist propranolol on hyperglycemia, inflammation, and brain injury in a rat model experiencing cerebral ischemia." | 3.96 | Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke. ( Chang, CY; Chen, CJ; Chen, WY; Kuan, YH; Liao, SL; Lin, SY; Wang, YY; Wu, CC, 2020) |
| " We hypothesize that judicious early low-dose propranolol after TBI (EPAT) will improve outcomes without altering bradycardia or hypotensive events." | 3.83 | Prospective evaluation of early propranolol after traumatic brain injury. ( Barmparas, G; Bloom, MB; Bukur, M; Harada, MY; Hoang, DM; Inaba, K; Ley, EJ; Margulies, DR; Murry, JS; Salim, A, 2016) |
| "Propranolol in vivo increased cerebral perfusion and decreased cerebral hypoxia." | 3.75 | The in vivo effect of propranolol on cerebral perfusion and hypoxia after traumatic brain injury. ( Conti, PS; Dagliyan, G; Ley, EJ; Margulies, DR; Park, R; Salim, A; Scehnet, J; Schroff, S, 2009) |
| " The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation." | 3.70 | Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999) |
| ") has been studied in 10 patients with various forms of hypertension under four different conditions: before and after salt depletion and with or without propranolol treatment." | 3.65 | Renin dependency of blood-pressure. Analysis by angiotensin II antagonist P113 in hypertensive patients treated with salt depletion and propranolol. ( Boer, P; Dorhout Mees, EJ; Geyskes, GG; Vos, J, 1976) |
| "Migraine is a hereditary disorder afflicting 5 per cent of school-age children." | 2.37 | Migraine in children. ( Fenichel, GM, 1985) |
| "Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg." | 1.72 | MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022) |
| " Administration of early propranolol was dosed within 24 hours of admission at 1 mg intravenous every 6 hours." | 1.43 | Early propranolol after traumatic brain injury is associated with lower mortality. ( Alban, RF; Barmparas, G; Bloom, MB; Chung, R; Harada, MY; Ko, A; Ley, EJ; Margulies, DR; Melo, N; Thomsen, GM, 2016) |
| "Propranolol patients were younger (30 years vs." | 1.40 | Traumatic brain injury and β-blockers: not all drugs are created equal. ( Clement, LP; Croce, MA; Fabian, TC; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP; Weinberg, JA, 2014) |
| " This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha1-NA antagonist, or propranolol (PROP), a beta-NA antagonist, would continue to reinstate hemiplegia over time after recovery from weight-drop traumatic brain injury (TBI)." | 1.31 | Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury. ( Feeney, DM; Stibick, DL, 2001) |
| "The propranolol was continued until all signs of autonomic dysfunction abated." | 1.29 | Fever of central origin in traumatic brain injury controlled with propranolol. ( Meythaler, JM; Stinson, AM, 1994) |
| "Pretreatment with propranolol produced a significant decrease in the prevalence of ascites compared with trauma alone (P less than 0." | 1.27 | Neurogenic hyperacute ascites in mice. ( Bensch, KG; Morin, ME; Murphy, BJ; Nelson, DP; Robin, ED; Theodore, J; Wong, RJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (34.38) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Wallen, TE | 1 |
| Baucom, MR | 1 |
| England, LG | 1 |
| Schuster, RM | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 1 |
| Lin, SY | 1 |
| Wang, YY | 1 |
| Chang, CY | 1 |
| Wu, CC | 1 |
| Chen, WY | 1 |
| Kuan, YH | 1 |
| Liao, SL | 1 |
| Chen, CJ | 1 |
| Yamada, H | 1 |
| Kikuchi, R | 1 |
| Katayama, J | 1 |
| Nakamura, A | 1 |
| Miyazaki, H | 1 |
| Schroeppel, TJ | 2 |
| Sharpe, JP | 1 |
| Magnotti, LJ | 1 |
| Weinberg, JA | 1 |
| Clement, LP | 1 |
| Croce, MA | 2 |
| Fabian, TC | 2 |
| Godoy, DA | 1 |
| Piñero, GR | 1 |
| Masotti, L | 1 |
| Murry, JS | 1 |
| Hoang, DM | 1 |
| Barmparas, G | 2 |
| Harada, MY | 2 |
| Bukur, M | 2 |
| Bloom, MB | 2 |
| Inaba, K | 1 |
| Margulies, DR | 5 |
| Salim, A | 4 |
| Ley, EJ | 5 |
| Kota, DJ | 1 |
| Prabhakara, KS | 1 |
| van Brummen, AJ | 1 |
| Bedi, S | 1 |
| Xue, H | 1 |
| DiCarlo, B | 1 |
| Cox, CS | 1 |
| Olson, SD | 1 |
| Ko, A | 1 |
| Thomsen, GM | 1 |
| Alban, RF | 1 |
| Chung, R | 1 |
| Melo, N | 1 |
| Scehnet, J | 1 |
| Park, R | 3 |
| Schroff, S | 1 |
| Dagliyan, G | 3 |
| Conti, PS | 3 |
| Palestrant, D | 1 |
| Miller, CM | 1 |
| Clond, MA | 1 |
| Chervonski, M | 1 |
| Lyden, PD | 1 |
| Patel, MB | 1 |
| McKenna, JW | 1 |
| Alvarez, JM | 1 |
| Sugiura, A | 1 |
| Jenkins, JM | 1 |
| Guillamondegui, OD | 1 |
| Pandharipande, PP | 1 |
| Fleminger, S | 2 |
| Greenwood, RJ | 2 |
| Oliver, DL | 2 |
| Mansheim, P | 1 |
| Meythaler, JM | 2 |
| Stinson, AM | 1 |
| Woiciechowsky, C | 1 |
| Asadullah, K | 1 |
| Nestler, D | 1 |
| Eberhardt, B | 1 |
| Platzer, C | 1 |
| Schöning, B | 1 |
| Glöckner, F | 1 |
| Lanksch, WR | 1 |
| Volk, HD | 1 |
| Döcke, WD | 1 |
| Wilkinson, R | 1 |
| Guin-Renfroe, S | 1 |
| Stibick, DL | 1 |
| Feeney, DM | 1 |
| Geyskes, GG | 1 |
| Boer, P | 1 |
| Vos, J | 1 |
| Dorhout Mees, EJ | 1 |
| Ellison, PH | 1 |
| Elliott, FA | 1 |
| Lewis, AB | 1 |
| Nestor, L | 1 |
| Dahms, B | 1 |
| Platzker, AC | 1 |
| Brooke, MM | 1 |
| Patterson, DR | 1 |
| Questad, KA | 1 |
| Cardenas, D | 1 |
| Farrel-Roberts, L | 1 |
| Griepp, EB | 1 |
| Griepp, RB | 1 |
| Nelson, DP | 1 |
| Robin, ED | 1 |
| Wong, RJ | 1 |
| Morin, ME | 1 |
| Bensch, KG | 1 |
| Murphy, BJ | 1 |
| Theodore, J | 1 |
| Fenichel, GM | 1 |
| Ulrich, G | 1 |
| Uchida, M | 1 |
| Yamaoka, H | 1 |
| Vander Ark, GD | 1 |
| Norton, LW | 1 |
| Pomerantz, M | 1 |
| Dasgupta, NK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status: A Randomized Controlled Trial (BBTBBT)[NCT04508244] | Phase 4 | 771 participants (Anticipated) | Interventional | 2020-12-29 | Recruiting | ||
| DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Severe Traumatic Brain Injury, A Pilot Randomized Clinical Trial Using Propranolol and Clonidine[NCT01322048] | Phase 2 | 48 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Controlling Hyperadrenergic Activity in Neurologic Injury[NCT01343329] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2011-07-31 | Withdrawn (stopped due to Unable to enroll subjects that fit study criteria.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01322048)
Timeframe: Post-treatment (t=Day 8)
| Intervention | pg/mL (Median) |
|---|---|
| Adrenergic Blockade | 962 |
| Placebo | 714 |
(NCT01322048)
Timeframe: Baseline to day 28
| Intervention | days (Median) |
|---|---|
| Adrenergic Blockade | 16.2 |
| Placebo | 18.05 |
4 reviews available for propranolol and Brain Injuries
| Article | Year |
|---|---|
Pharmacological management for agitation and aggression in people with acquired brain injury.
Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat | 2003 |
Pharmacological management for agitation and aggression in people with acquired brain injury.
Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat | 2006 |
Cerebral consequences of hypothermic circulatory arrest in adults.
Topics: Animals; Barbiturates; Body Temperature; Brain; Brain Injuries; Calcium Channel Blockers; Clinical T | 1992 |
Migraine in children.
Topics: Adolescent; Basilar Artery; Brain Injuries; Cerebrovascular Circulation; Child; Child, Preschool; Co | 1985 |
2 trials available for propranolol and Brain Injuries
| Article | Year |
|---|---|
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Biomarkers; Br | 2012 |
The treatment of agitation during initial hospitalization after traumatic brain injury.
Topics: Aggression; Brain Injuries; Humans; Propranolol; Psychomotor Agitation; Restraint, Physical | 1992 |
26 other studies available for propranolol and Brain Injuries
| Article | Year |
|---|---|
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th | 2022 |
Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke.
Topics: Adrenergic beta-Antagonists; Animals; Brain Injuries; Cell Line; Cytokines; Disease Models, Animal; | 2020 |
Paroxysmal Sympathetic Hyperactivity after Surgery for Cerebral Hemorrhagic Arteriovenous Malformation: A Case Report.
Topics: Adolescent; Adrenergic beta-Antagonists; Amines; Autonomic Nervous System Diseases; Brain Injuries; | 2018 |
Traumatic brain injury and β-blockers: not all drugs are created equal.
Topics: Adrenergic beta-Antagonists; Adult; Brain Injuries; Cause of Death; Cohort Studies; Confidence Inter | 2014 |
Paroxysmal sympathetic hyperactivity, traumatic brain injury, and β-blockers.
Topics: Adrenergic beta-Antagonists; Brain Injuries; Female; Hospital Mortality; Humans; Male; Primary Dysau | 2014 |
Re: Paroxysmal sympathetic hyperactivity, traumatic brain injury, and β-blockers: Not all drugs are created equal.
Topics: Adrenergic beta-Antagonists; Brain Injuries; Female; Hospital Mortality; Humans; Male; Primary Dysau | 2014 |
Prospective evaluation of early propranolol after traumatic brain injury.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Bradycardia; Brain Injuries; Drug Administration Schedule; | 2016 |
Propranolol and Mesenchymal Stromal Cells Combine to Treat Traumatic Brain Injury.
Topics: Adult; Allografts; Animals; Bone Marrow Cells; Brain Injuries; Humans; Male; Mesenchymal Stem Cell T | 2016 |
Early propranolol after traumatic brain injury is associated with lower mortality.
Topics: Abbreviated Injury Scale; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brain Injurie | 2016 |
The in vivo effect of propranolol on cerebral perfusion and hypoxia after traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Cerebrovascular Circulation; Hypoxia; Immunohistochem | 2009 |
In vivo effect of propranolol dose and timing on cerebral perfusion after traumatic brain injury.
Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Mice; Mice, | 2010 |
β-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury.
Topics: Adrenergic beta-Antagonists; Animals; Blotting, Western; Brain; Brain Chemistry; Brain Injuries; Glu | 2012 |
Treatment with propranolol of the behavioral sequelae of brain damage.
Topics: Adult; Brain Injuries; Female; Humans; Neurocognitive Disorders; Propranolol; Social Behavior Disord | 1981 |
Fever of central origin in traumatic brain injury controlled with propranolol.
Topics: Accidents, Traffic; Adolescent; Adult; Body Temperature Regulation; Brain Injuries; Female; Fever; H | 1994 |
Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Animals; Brain; Brain Injuries; Brain Neoplasms; Brain Ste | 1998 |
Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury.
Topics: Adolescent; Amantadine; Brain Injuries; Dopamine Agents; Dopamine Antagonists; Fever; Haloperidol; H | 1999 |
Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; | 2001 |
Renin dependency of blood-pressure. Analysis by angiotensin II antagonist P113 in hypertensive patients treated with salt depletion and propranolol.
Topics: Adolescent; Adult; Angiotensin II; Antihypertensive Agents; Blood Pressure; Brain Injuries; Diet, So | 1976 |
Propranolol for severe post-head injury action tremor.
Topics: Brain Injuries; Child; Humans; Male; Movement; Propranolol; Tremor | 1978 |
Propranolol for the control of belligerent behavior following acute brain damage.
Topics: Adult; Aggression; Brain Concussion; Brain Injuries; Cerebrovascular Disorders; Humans; Male; Middle | 1977 |
Cardiovascular responses to autonomic blockade in brain-injured fetal lambs.
Topics: Animals; Atropine; Autonomic Nerve Block; Blood Pressure; Brain; Brain Injuries; Carotid Arteries; G | 1978 |
Neurogenic hyperacute ascites in mice.
Topics: Acute Disease; Adrenergic beta-Agonists; Animals; Ascitic Fluid; Brain Injuries; Male; Methoxamine; | 1986 |
[Guide lines for the treatment of patients with the apallic and postopallic syndrome].
Topics: Amino Acids; Brain Diseases; Brain Injuries; Cachexia; Cerebral Cortex; Contracture; Diet Therapy; D | 1973 |
[Effect of beta adrenergic blocking agents on the changes of the ST segment and T wave observed in patients with brain-stem damage].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Brain Injuries; Brain Neoplasms; Brain Ste | 1972 |
The effects of brain stem compression on the heart.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bradycardia; Brain Injuries; Brain Stem; Ca | 1974 |
On the mechanism of the pressor response due to propranolol.
Topics: Animals; Blood Pressure; Brain Injuries; Bretylium Compounds; Heart Rate; Hexamethonium Compounds; I | 1968 |