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propranolol and Agoraphobia

propranolol has been researched along with Agoraphobia in 13 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Agoraphobia: Obsessive, persistent, intense fear of open places.

Research Excerpts

ExcerptRelevanceReference
"Fifty-five patients completed a 5-week double-blind study comparing alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks."9.06Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. ( Brown, R; Cabe, D; Crocker, B; Leonard, M; McDowell, D; McManus, M; Munjack, DJ; Palmer, R; Usigli, R; Zulueta, A, 1989)
"The response to diazepam and propranolol hydrochloride was compared in 21 patients who (with one exception) met DSM-III criteria for panic disorder and agoraphobia."9.05Diazepam and propranolol in panic disorder and agoraphobia. ( Anderson, DJ; Clancy, J; Crowe, RR; Ghoneim, MM; Hinrichs, JV; Noyes, R; Slymen, DJ, 1984)
"The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and crossover design."9.05Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia. ( Anderson, DJ; Ghoneim, MM; Hinrichs, JV; Noyes, R, 1984)
"We studied the efficacy of propranolol (Inderal) compared to alprazolam (Xanax) in 29 patients with a diagnosis of agoraphobia with panic disorder or panic disorder with or without limited phobic avoidance in a 6-week double-blind controlled experiment."5.07A controlled study of alprazolam and propranolol in panic-disordered and agoraphobic outpatients. ( Friedman, MJ; Hauri, PJ; McHugo, GJ; Ravaris, CL, 1991)
"Fifty-five patients completed a 5-week double-blind study comparing alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks."5.06Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. ( Brown, R; Cabe, D; Crocker, B; Leonard, M; McDowell, D; McManus, M; Munjack, DJ; Palmer, R; Usigli, R; Zulueta, A, 1989)
"The response to diazepam and propranolol hydrochloride was compared in 21 patients who (with one exception) met DSM-III criteria for panic disorder and agoraphobia."5.05Diazepam and propranolol in panic disorder and agoraphobia. ( Anderson, DJ; Clancy, J; Crowe, RR; Ghoneim, MM; Hinrichs, JV; Noyes, R; Slymen, DJ, 1984)
"The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and crossover design."5.05Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia. ( Anderson, DJ; Ghoneim, MM; Hinrichs, JV; Noyes, R, 1984)
" Among the more important recent discoveries are the efficacy of the tricyclic antidepressants for panic disorder and agoraphobia with panic attacks; the use of the monoamine oxidase inhibitors for the above disorders and for atypical depression and hysteroid dysphoria; the use of propranolol for anxiety disorders and for uncontrollable violent outbursts; the antianxiety and antipanic effects of clonidine; and the usefulness of lithium in treating schizophrenia and schizoaffective disorder and for emotionally unstable character disorders."4.76Newer uses for older psychotropic medications. ( Liebowitz, MR, 1982)
"Ten cases are presented--two in detail--in which clonazepam was used successfully in patients with treatment-resistant panic disorder with or without agoraphobia."3.67Successful use of clonazepam in patients with treatment-resistant panic disorder. ( Rosenbaum, JF; Tesar, GE, 1986)
"Panic disorder is characterised by recurrent unexpected panic attacks consisting of a wave of intense fear that reaches a peak within a few minutes."2.61Benzodiazepines versus placebo for panic disorder in adults. ( Barbui, C; Bighelli, I; Breilmann, J; Castellazzi, M; Cipriani, A; Davies, SJ; Furukawa, TA; Girlanda, F; Guaiana, G; Koesters, M, 2019)
"Propranolol was effective in treating acute pathological panic, but modest doses of the drug administered for brief periods of time did not alleviate chronic panic attacks associated with agoraphobia."1.26The treatment of pathological panic states with propranolol. ( Defrancisco, D; Heiser, JF, 1976)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199010 (76.92)18.7374
1990's2 (15.38)18.2507
2000's0 (0.00)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Breilmann, J1
Girlanda, F1
Guaiana, G1
Barbui, C1
Cipriani, A1
Castellazzi, M1
Bighelli, I1
Davies, SJ1
Furukawa, TA1
Koesters, M1
Liebowitz, MR2
Gorman, JM1
Levy, GF1
McGrath, P1
Appleby, IL1
Dillon, DJ1
Davies, SO1
Klein, DF1
Noyes, R2
Anderson, DJ2
Clancy, J1
Crowe, RR1
Slymen, DJ1
Ghoneim, MM2
Hinrichs, JV2
Hafner, J1
Milton, F1
Heiser, JF1
Defrancisco, D1
Ravaris, CL1
Friedman, MJ1
Hauri, PJ1
McHugo, GJ1
Yeragani, VK1
Pohl, R1
Balon, R1
Aronson, TA1
Carasiti, I1
McBane, D1
Whitaker-Azmitia, P1
Munjack, DJ1
Crocker, B1
Cabe, D1
Brown, R1
Usigli, R1
Zulueta, A1
McManus, M1
McDowell, D1
Palmer, R1
Leonard, M1
Griez, E1
van den Hout, MA1
Tesar, GE1
Rosenbaum, JF1

Reviews

2 reviews available for propranolol and Agoraphobia

ArticleYear
Benzodiazepines versus placebo for panic disorder in adults.
    The Cochrane database of systematic reviews, 2019, Mar-28, Volume: 3

    Topics: Adult; Aged; Agoraphobia; Benzodiazepines; Buspirone; Humans; Imipramine; Middle Aged; Numbers Neede

2019
Newer uses for older psychotropic medications.
    Hospital & community psychiatry, 1982, Volume: 33, Issue:4

    Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive

1982

Trials

6 trials available for propranolol and Agoraphobia

ArticleYear
Diazepam and propranolol in panic disorder and agoraphobia.
    Archives of general psychiatry, 1984, Volume: 41, Issue:3

    Topics: Adult; Agoraphobia; Anxiety Disorders; Clinical Trials as Topic; Depression; Diazepam; Double-Blind

1984
Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia.
    Neuropsychobiology, 1984, Volume: 11, Issue:4

    Topics: Adult; Agoraphobia; Clinical Trials as Topic; Cognition; Diazepam; Double-Blind Method; Fear; Female

1984
The influence of propranolol on the exposure in vivo of agoraphobics.
    Psychological medicine, 1977, Volume: 7, Issue:3

    Topics: Adult; Agoraphobia; Clinical Trials as Topic; Double-Blind Method; Female; Follow-Up Studies; Heart

1977
A controlled study of alprazolam and propranolol in panic-disordered and agoraphobic outpatients.
    Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:6

    Topics: Adolescent; Adult; Agoraphobia; Alprazolam; Double-Blind Method; Female; Humans; Male; Middle Aged;

1991
Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Agoraphobia; Alprazolam; Clinical Trials as Topic; Double-Blind Method; Fear; Fem

1989
CO2 inhalation in the treatment of panic attacks.
    Behaviour research and therapy, 1986, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Agoraphobia; Carbon Dioxide; Fear; Female; Follow-Up Studies; Humans; Male; Middl

1986

Other Studies

5 other studies available for propranolol and Agoraphobia

ArticleYear
Effect of acute beta-adrenergic blockade on lactate-induced panic.
    Archives of general psychiatry, 1983, Volume: 40, Issue:10

    Topics: Adult; Agoraphobia; Blood Pressure; Fear; Female; Heart Rate; Humans; Lactates; Lactic Acid; Male; M

1983
The treatment of pathological panic states with propranolol.
    The American journal of psychiatry, 1976, Volume: 133, Issue:12

    Topics: Acute Disease; Adult; Agoraphobia; Anxiety Disorders; Chronic Disease; Depression; Depressive Disord

1976
Lactate-induced panic and beta-adrenergic blockade.
    Psychiatry research, 1990, Volume: 32, Issue:1

    Topics: Adult; Agoraphobia; Arousal; Dose-Response Relationship, Drug; Fear; Female; Heart Rate; Humans; Inf

1990
Biological correlates of lactate sensitivity in panic disorder.
    Biological psychiatry, 1989, Volume: 26, Issue:5

    Topics: Adult; Agoraphobia; Arousal; Dihydroalprenolol; Fear; Female; Heart Rate; Humans; Hydrocortisone; La

1989
Successful use of clonazepam in patients with treatment-resistant panic disorder.
    The Journal of nervous and mental disease, 1986, Volume: 174, Issue:8

    Topics: Adult; Agoraphobia; Alprazolam; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clonazepam; D

1986