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propranolol and Aging

propranolol has been researched along with Aging in 262 studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The influence of aging on the hepatic metabolism of propranolol, i."9.08Influence of aging on the oxidative and conjugative metabolism of propranolol. ( Ebihara, A; Fujimura, A; Ohashi, K; Shiga, T; Tateishi, T, 1995)
"The influence of aging on the pharmacokinetics and the tissue distribution of (R)- and of (S)-propranolol was studied in 3-, 12-, and 24-month-old rats."7.68The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat. ( Belpaire, FM; Bogaert, MG; de Smet, F; Moerman, E; Vermeulen, AM, 1992)
"The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0."7.68The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991)
" Salivary flow rates, induced by pilocarpine, were not decreased by the chronic administration of propranolol."5.29The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993)
" administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age."5.28Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990)
"The effects of aging on alpha(1)-adrenoceptor (alpha(1)-AR)-mediated contractile response in endothelium-removed aortic preparations isolated from 5- to 40-week-old (5-, 6-, 8-, 10-, 20-, 40-weeks) mice were studied in the presence of propranolol."3.73Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation. ( Funabiki, M; Koike, K; Michikawa, H; Tanaka, Y, 2006)
"We analysed the influence of aging on the acute effect of clenbuterol, a beta(2)-adrenoceptor agonist, on the vasoconstrictor response induced by electrical field stimulation in mesenteric arteries from young and old spontaneously hypertensive rats (SHRs)."3.72Different effects of acute clenbuterol on vasomotor response in mesenteric arteries from young and old spontaneously hypertensive rats. ( Balfagón, G; Ferrer, M; Salaices, M; Sánchez, M, 2003)
"Blood stroke volume in rats aging 21 and 56 days decreased during beta-adrenoceptor blockade with propranolol, but increased again by the 15th minute after treatment."3.72Age-related differences in the response of blood stroke volume to stimulation of the sympathetic ganglion in rats with beta-adrenoceptor blockade. ( Anikina, TA; Bilalova, GA; Sitdikov, FG, 2004)
"We previously reported that insulin-induced hypoglycemia (IIH) induces a large increase in plasma ACTH and corticosterone levels in the developing rat during the stress hyporesponsive period and that this effect is mediated, at least partially, by arginine vasopressin (AVP), but not corticotropin-releasing factor."3.68Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. ( Grino, M; Oliver, C, 1992)
"The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0."3.68The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991)
" In 20 subjects with uncomplicated essential hypertension, 10 of whom were on propranolol treatment, several blood samples were drawn simultaneously from the renal artery and vein after angiographic studies."3.66Noradrenaline secretion by the human kidney. ( Birkenhäger, WH; de Leeuw, PW; Falke, HE; Punt, R, 1978)
" To determine whether age-related changes in alpha 1-acid glycoprotein influence drug binding in mother and newborn infant and also the effects of sex, pregnancy, and oral contraceptives on drug binding, the binding of lidocaine, diazepam, propranolol, d-tubocurarine, and metocurine was determined by equilibrium dialysis in 17 men, 16 nonpregnant women, 16 nonpregnant women on oral contraceptives, and 15 mothers and their newborn infants at delivery."3.66Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant. ( Wood, AJ; Wood, M, 1981)
" Bioavailability of tetrahydrobiopterin (BH4), an essential cofactor for catecholamine synthesis, is reduced with aging."2.78Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms. ( Alexander, LM; Kenney, WL; Stanhewicz, AE, 2013)
" No statistical differences were detected in the experimental propranolol pharmacokinetic parameters (maximal concentration, time of maximal concentration, terminal half-life, area under the curve, and protein binding) or derived pharmacokinetic parameters (intrinsic clearance, bioavailability, clearance, and volume of distribution)."2.68The lack of effect of aerobic exercise training on propranolol pharmacokinetics in young and elderly adults. ( Cediel, M; Derendorf, H; Garzarella, L; Graves, JE; Guillen, GJ; Krumerman, J; Panton, LB; Pollock, ML; Vivas, C; Williams, L, 1995)
" Drug interaction studies with fluvastatin and cholestyramine (CME) demonstrated a lower rate and extent of fluvastatin bioavailability; no impact on efficacy was demonstrated when CME was given 4 h before fluvastatin dosing in clinical trials."2.67Pharmacokinetics of fluvastatin and specific drug interactions. ( Hwang, DS; Jokubaitis, LA; Robinson, WT; Smith, HT; Troendle, AJ, 1993)
"Propranolol prevented the increase in QT/QS2 ratio induced by active standing."2.66Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes. ( Acanfora, D; Canonico, V; Cicatiello, AM; Cuomo, S; De Caprio, L; Gallucci, F; Papa, M; Rengo, F; Vigorito, C, 1989)
"1 Pharmacokinetic investigations were carried out in a group of 32 ambulant normal male volunteers in order to determine the effect of age and smoking on steady-state plasma levels of pindolol and propranolol."2.65Effects of age and smoking on the pharmacokinetics of pindolol and propranolol. ( Beveridge, T; Fitscha, P; Hitzenberger, G; Nüesch, E; Pacha, W, 1982)
"This tremor is normally recordable at a stable frequency of 8-10 Hz, though this can be influenced by age, the amplitude can vary substantially."2.39[Most frequent causes for hand tremor in clinical practice]. ( Málly, J, 1995)
"When propranolol was administered at either 5-, 60-, or 120-min post-training, there was an inhibition of conditioned responses, these data support the hypothesis that NE is important for consolidation of learning."1.35Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age. ( Avilas, M; Bickford, PC; Cartford, MC; Catlow, BJ; George, A; Paredes, DA; Samec, A; Schlunck, A; Small, B, 2009)
" Local BH(4) supplementation augments reflex and tyramine-induced VC in aged skin, suggesting that reduced BH(4) bioavailability may contribute to attenuated VC during whole-body cooling."1.35Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans. ( Holowatz, LA; Kenney, WL; Lang, JA, 2009)
" Salivary flow rates, induced by pilocarpine, were not decreased by the chronic administration of propranolol."1.29The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993)
"Propranolol treatment (10(-5) M) increased Fmax (2-fold) only for newborn lamb MCAs."1.29Nitric oxide and beta-adrenergic mechanisms modify contractile responses to norepinephrine in ovine fetal and newborn cerebral arteries. ( Moliken, W; Russo, P; Wagerle, LC, 1995)
"We studied the effects of chronic administration of beta-adrenoceptor antagonists with and without intrinsic sympathomimetic activity (ISA): carteolol (with ISA) and propranolol (without ISA), respectively, on the heart of spontaneously hypertensive rat (SHR) and Wistar Kyoto rat (WKY)."1.28Effects of chronic administration of carteolol on beta-adrenoceptors in spontaneously hypertensive rat heart. ( Ebii, K; Fujiwara, M; Fukunaga, R; Kimura, Y; Nakayama, S; Saitoh, Y; Taniguchi, T, 1991)
" We therefore conclude: (i) that the diminution of the cardiac response to the sympathetic and vagal stimulations during ageing may be partly explained by a decrease in the corresponding receptor density; (ii) these changes are reversible and the density of these two groups of receptors can return to adult control values by chronic administration of the appropriate antagonist."1.28Alterations in beta adrenergic and muscarinic receptors in aged rat heart. Effects of chronic administration of propranolol and atropine. ( Callen-el Amrani, F; Chevalier, B; Mansier, P; Swynghedauw, B; Teiger, E, 1991)
" Pharmacokinetic variable values in elderly subjects did not differ in a clinically significant manner from those in younger subjects."1.28Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam. ( Karim, A; Nicholson, PA; Smith, M, 1990)
" administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age."1.28Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990)
" Cumulative dose-response curves of plasma cyclic AMP concentration obtained in another group of rats after successive subcutaneous injections of isoproterenol showed that the ED50 value of this drug was higher in SHR than in WKY and increased in a parallel manner in the two strains between 7 and 18 weeks of age (respectively from 0."1.27Age-related changes of in vivo beta-adrenergic responsiveness in normotensive and spontaneously hypertensive rats. ( Bucher, B; Heitz, C; Stoclet, JC, 1984)
"0 mg/kg intravenously) was administered after the highest phenylephrine infusion dosage to assure complete beta-blockade."1.27In vivo demonstration of maturational changes of the chronotropic response to alpha-adrenergic stimulation. ( Gelband, H; McCormack, J; Pickoff, AS; Stolfi, A; Villafañe, J; Xu, H, 1988)
" Pharmacokinetic analysis of the plasma propranolol data obtained after i."1.27Effect of age on the hepatic clearance of propranolol in rats. ( Araki, K; Deguchi, N; Iwamoto, K; Sugiyama, H; Watanabe, J, 1985)
"82 ml/min/kg) and prolonged elimination half-life (29 vs."1.27Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol. ( Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Ochs, HR; Shader, RI, 1987)
" Although there was a statistically significant difference in certain pharmacokinetic parameters (maximum plasma concentration, area under the curve, elimination constant and elimination half-life) between elderly patients (more that 60 years) and young persons (20-30 years) no significant differences were found as far as smoking and nonsmoking is concerned."1.26Influence of smoking and age on pharmacokinetics of beta-receptor blockers. ( Beveridge, T; Fitscha, P; Hitzenberger, G; Nüesch, E; Pacha, W, 1982)
" No age differences were seen in the time course of amylase release following (-)-isoproterenol stimulation or in the (-)-isoproterenol dose-response curve."1.26Beta-adrenergic regulation of rat parotid gland exocrine protein secretion during aging. ( Baum, BJ; Ito, H; Roth, GS, 1981)
"Propranolol did not cause this pressor effect in prehypertensive (seven week old) SHRs."1.26Beta-adrenergic receptor blocking drugs in spontaneous hypertension. ( Levy, JV, 1976)
" The terminal half-life of propranolol was similar in the two groups after oral propranolol but significantly shorter in the young after intravenous dosing (P less than 0."1.26The effect of ageing on the hepatic clearance of propranolol. ( Castleden, CM; George, CF, 1979)
" Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED50 and the LD50."1.26Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice. ( Felleman, VH; Palfai, T, 1982)
"7 Cimetidine was without effect on histamine sensitivity in young guinea-pigs after propranolol treatment but significantly reduced airway sensitivity to histamine in old guinea-pigs."1.26Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development. ( Brink, C; Douglas, JS; Duncan, PG, 1982)
"The biphasic nature of the lipolytic dose-response curve of epinephrine in fat cells from "young" rats (40-45 days) was confirmed."1.25Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats. ( Allen, DO; Miller, EA, 1973)

Research

Studies (262)

TimeframeStudies, this research(%)All Research%
pre-1990148 (56.49)18.7374
1990's73 (27.86)18.2507
2000's24 (9.16)29.6817
2010's16 (6.11)24.3611
2020's1 (0.38)2.80

Authors

AuthorsStudies
Evans, AK1
Park, HH1
Saw, NL1
Singhal, K1
Ogawa, G1
Leib, RD1
Shamloo, M1
Bilalova, GA3
Sitdikov, FG3
Dikopol'skaya, NB1
Shaikhelislamova, MV1
Zefirov, TL1
Chatzidou, S1
Georgiopoulos, G1
Kontogiannis, C1
Stanhewicz, AE1
Alexander, LM1
Kenney, WL2
Muller, MD2
Gao, Z2
Patel, HM1
Heffernan, MJ1
Leuenberger, UA2
Sinoway, LI2
Bratt, EL1
Östman-Smith, I1
Ross, AJ1
Pollock, JP1
Blagosklonny, MV1
Sun, X1
Su, Y1
He, Y1
Zhang, J1
Liu, W1
Zhang, H1
Hou, Z1
Liu, J1
Li, J1
Skelly, MJ1
Chappell, AE1
Carter, E1
Weiner, JL1
Briant, LJ1
Burchell, AE1
Ratcliffe, LE1
Charkoudian, N1
Nightingale, AK1
Paton, JF1
Joyner, MJ1
Hart, EC1
Fernandois, D1
Cruz, G1
Na, EK1
Lara, HE1
Paredes, AH1
Paredes, DA1
Cartford, MC1
Catlow, BJ1
Samec, A1
Avilas, M1
George, A1
Schlunck, A1
Small, B1
Bickford, PC1
Wray, DW1
Nishiyama, SK1
Richardson, RS1
Mongue-Din, H1
Salmon, A1
Fiszman, MY1
Fromes, Y1
Lang, JA1
Holowatz, LA1
Koyanagi, Y1
Yamamoto, K1
Oi, Y1
Koshikawa, N1
Kobayashi, M1
Fedorets, VN1
Snyder, KA1
Shamimi-Noori, S1
Wilson, TE1
Monahan, KD1
Ghosh, PM1
Shu, ZJ1
Zhu, B1
Lu, Z1
Ikeno, Y1
Barnes, JL1
Yeh, CK1
Zhang, BX1
Katz, MS2
Kamat, A1
Dobarro, M1
Orejana, L1
Aguirre, N1
Ramírez, MJ1
Ferrer, M2
Salaices, M2
Sánchez, M1
Balfagón, G3
Tamaya-Mori, N1
Uemura, K1
Tanaka, S2
Iguchi, A1
Braga, MF1
Aroniadou-Anderjaska, V1
Manion, ST1
Hough, CJ1
Li, H1
Anikina, TA2
Plećas-Solarović, B1
Lalić, L1
Leposavić, G1
Ruiz-Feria, CA1
Yang, Y1
Nishimura, H1
Cruickshank, JM1
Tanaka, Y1
Funabiki, M1
Michikawa, H1
Koike, K2
Ohe, T1
Imamura, K2
Kasamatsu, T2
Švíglerová, J1
Kuncová, J1
Nalos, L1
Slavíková, J1
Stengl, M1
Bucher, B1
Heitz, C1
Stoclet, JC1
Gatto, C1
Johnson, MG1
Seybold, V1
Kulik, TJ1
Lock, JE1
Johnson, DE1
Bianchetti, G1
Brancaccio, D1
Forette, F1
Henry, JF1
Hervy, MP1
Ganansia, J1
Gomeni, R1
Kilborn, JR1
Morselli, PL1
Hitzenberger, G2
Fitscha, P2
Beveridge, T2
Nüesch, E2
Pacha, W2
Minaker, KL1
Rowe, JW2
McKenna, WJ1
Borggrefe, M1
England, D1
Deanfield, J1
Oakley, CM1
Goodwin, JF1
Twomey, JJ1
Kouttab, NM1
Stiles, GL1
Caron, MG1
Lefkowitz, RJ1
Ito, H1
Baum, BJ2
Roth, GS2
Kim, SK1
Calkins, DW1
Weinhold, PA1
Carlsöö, B1
Danielsson, A1
Henriksson, R1
Yamazaki, N1
Hosoki, R1
Takayanagi, I2
Abrass, IB1
Scarpace, PJ1
Troen, BR1
Chen, FC1
Yamamura, HI1
Roeske, WR1
Morgan, NG1
Blackmore, PF1
Exton, JH1
Marin-Cao, D1
Alvarez Chiva, V1
Mato, JM1
O'Donnell, SR2
Wanstall, JC2
Reaven, E1
Wright, D2
Mondon, CE3
Solomon, R1
Ho, H1
Reaven, GM3
Speiser, Z1
Shved, A1
Gitter, S1
Narimiya, M1
Azhar, S1
Dolkas, CB1
Sims, C1
Wright, DW1
Brink, C1
Douglas, JS1
Duncan, PG1
Caza, PA1
Babak, OIa1
Ferguson, AV1
Bauce, L1
Veale, WL1
Cooper, KE1
Bendayan, R1
Pieper, JA1
Stewart, RB2
Caranasos, GJ1
Greenfield, MS1
Rosenthal, M1
Reaven, EP1
Szabolcs, I2
Szilágyi, G2
Góth, M2
Kovács, Z2
Weber, M2
Halász, T2
Heath, M1
Ingram, DL1
Deguchi, T1
Driscoll, DJ1
Fukushige, J1
Lewis, RM1
Hartley, CJ1
Entman, MJ1
King, TS1
Dougherty, WJ1
Yorek, MA1
Blair, JB3
Ray, PD1
Palfai, T1
Felleman, VH1
Brammer, M1
Binkley, S1
Mosher, K1
Irsy, G1
Lowenthal, DT1
Affrime, MB1
Yin, FC2
Weisfeldt, ML3
Milnor, WR1
Park, MK1
Wexler, BC1
McMurtry, JP1
de Champlain, J1
Cousineau, D1
Lapointe, L1
Wood, M1
Wood, AJ3
Málly, J1
Wagerle, LC1
Moliken, W1
Russo, P1
Iushkova, AA1
Dygalo, NN1
Pacioretty, LM1
Gilmour, RF1
Conlon, D2
Johnston, A2
O'Malley, K2
Turner, P2
Kilfeather, S2
Kyriakides, ZS1
Papaioannou, G1
Paraskevaidis, IA1
Kolettis, TM1
Kremastinos, DT1
Craft, N1
Schwartz, JB3
Tanaka, H2
Manita, S1
Matsuda, T1
Adachi, M1
Shigenobu, K1
Vercruysse, I1
Vermeulen, AM4
Belpaire, FM4
Massart, DL1
Dupont, AG1
Shen, C1
Garcia, J2
Capili, H1
Sniezek, M1
Wilson, DA2
Pham, TC1
Sullivan, RM1
Fleg, JL1
Schulman, S1
O'Connor, F1
Becker, LC1
Gerstenblith, G2
Clulow, JF1
Renlund, DG1
Lakatta, EG3
van Veldhuizen, MJ1
Feenstra, MG1
Botterblom, MH1
Boer, GJ1
Arribas, S1
Marín, J1
Ponte, A1
Coutinho, LL1
Bergen, WG1
Romsos, DR1
Merkel, RA1
Pucéat, M1
Hilal-Dandan, R1
Strulovici, B1
Brunton, LL1
Brown, JH1
O'Connell, AC2
Van Wuyckhuyse, BC1
Pearson, SK1
Bowen, WH2
Banerjee, A1
Brook, MM1
Klautz, RJ1
Teitel, DF2
Smith, HT1
Jokubaitis, LA1
Troendle, AJ1
Hwang, DS1
Robinson, WT1
Liu, QY1
Karpinski, E1
Pang, PK1
Polio, J1
Sieber, CC1
Lerner, E1
Groszmann, RJ1
Kuga, K1
Yamaguchi, I1
Sugishita, Y1
Kennedy, AT1
Kitchen, I1
Hill, RG1
Haidet, GC1
de Smet, F3
Bogaert, MG3
Knudsen, JH1
Christensen, NJ1
Bratholm, P1
Panton, LB1
Guillen, GJ1
Williams, L1
Graves, JE1
Vivas, C1
Cediel, M1
Pollock, ML1
Garzarella, L1
Krumerman, J1
Derendorf, H1
Tateishi, T1
Fujimura, A1
Shiga, T1
Ohashi, K1
Ebihara, A1
Harmouch, A1
Guerrero, JM1
Pozo, D1
Rafii-el-Idrissi, M1
Calvo, JR1
Reiter, RJ1
Osuna, C1
Xie, LH1
Takano, M1
Noma, A1
Basso, A1
Piantanelli, L1
Rossolini, G1
Baylis, C1
Engels, K1
Beierwaltes, WH1
Miller, EA1
Allen, DO1
Oida, E2
Kannagi, T2
Moritani, T2
Yamori, Y2
Nigmatullina, RR1
Abzalov, RA1
Minnibaev, ESh1
Masuda, Y2
Suzuki, M1
Akagawa, Y1
Takemura, T1
Dash, R1
Kadambi, V1
Schmidt, AG1
Tepe, NM1
Biniakiewicz, D1
Gerst, MJ1
Canning, AM1
Abraham, WT1
Hoit, BD1
Liggett, SB1
Lorenz, JN1
Dorn, GW1
Kranias, EG1
Tsakiris, S1
Aikawa, K1
Yokota, T1
Okamura , H1
Yamaguchi, O1
Bell, C1
Seals, DR2
Monroe, MB1
Day, DS1
Shapiro, LF1
Johnson, DG1
Jones, PP1
Piccirillo, G1
Cacciafesta, M1
Lionetti, M1
Nocco, M1
Di Giuseppe, V1
Moisè, A1
Naso, C1
Marigliano, V1
Dinenno, FA1
Stauffer, BL1
Folkesson, HG1
Matthay, MA1
Chapin, CJ1
Porta, NF1
Kitterman, JA1
Abdel-Latif, AA1
Levy, JV1
Saarela, S1
Mattila, T1
Hissa, R1
Hohtola, E1
Bühler, FR3
Berkowitz, BA1
Lütold, BE2
Singh, U1
Millson, DS1
Smith, PA1
Owen, JJ1
Smith, CR1
James, ME2
Foster, JL2
Watson, RD1
Stallard, TJ1
Littler, WA1
Burch, GE1
Vlk, J1
Da Prada, M1
Melville, GN1
Iravani, J1
Vassell, M1
Minnis, J1
de Leeuw, PW1
Falke, HE1
Punt, R1
Birkenhäger, WH1
Wilkinson, GR2
Vestal, RE1
Branch, RA1
Shand, DG1
Karmazyn, M1
Horrobin, DF1
Oka, M1
Manku, MS1
Ally, AI1
Karmali, RA1
Morgan, RO1
Cunnane, SC1
Frol'kis, VV1
Verkhratskiĭ, NS1
Shevchuk, VG1
Woods, WT1
Urthaler, F1
James, TN1
Woods, JR1
Dandavino, A1
Brinkman, CR1
Nuwayhid, B1
Assali, NS1
Feely, J1
Stevenson, IH1
Raizes, GS1
Guarnieri, T1
Spurgeon, HA1
Fortuin, NJ1
Castleden, CM2
George, CF1
Beasley, BA1
Ford, DH1
Jusko, WJ1
Gretch, M1
Wilson, DE1
Jubiz, W1
Flowers, CM1
Carlile, SI1
Adolf, AM1
Bartolomé, J1
Lau, C1
Slotkin, TA2
Corre, KA1
Cho, H1
Barnard, RJ1
Mielens, E1
Rosenberg, FJ1
Linnoila, M1
Cooper, RL1
Rane, A1
Wilson, JT1
Harkins, SW1
Thompson, LW1
Moss, SF1
Nowlin, JB1
Portzer, D1
Angell, CS3
Shock, NW3
Roberts, J2
Goldberg, PB1
Caspari, PG1
Gibson, K1
Harris, P1
Kaye, CM1
Parsons, RL1
Legault, L1
van Nguyen, P1
Holliwell, DL1
Leenen, FH1
Mader, SL1
Colangelo, PM2
Blouin, RA2
Steinmetz, JE2
McNamara, PJ2
DeMaria, AN2
Wedlund, PJ2
Teräväinen, TL2
Buñag, RD4
Van Ermen, A1
Van de Velde, E1
Vanscheeuwijck, P2
Fraeyman, N2
Grino, M1
Oliver, C1
Pristrom, MS1
Mrochek, AG1
Gorbachev, VV1
Tiabut, TD1
Zhou, HH1
Whelan, E1
Gilmore, DA1
Gal, J1
Gerber, JG1
Nies, AS1
Moerman, E1
Mortimer, ML1
Tumer, N1
Johnson, MD1
Jahromi, SS1
Niesen, C1
Carlen, PL1
Wagner, JP1
Seidler, FJ1
Ebii, K1
Fukunaga, R1
Taniguchi, T1
Fujiwara, M1
Nakayama, S1
Saitoh, Y1
Kimura, Y1
Chevalier, B1
Mansier, P1
Teiger, E1
Callen-el Amrani, F1
Swynghedauw, B1
Khoreva, SA1
Vasil'ev, NV1
Ford, GA1
Hoffman, BB1
Blaschke, TF1
Sandroni, P1
Benarroch, EE1
Low, PA1
Melvin, JE1
Koek, L1
Murohara, T1
Yasue, H1
Ohgushi, M1
Sakaino, N1
Jougasaki, M1
Barringer, DL2
Felder, CC1
Piccio, MM1
McKelvey, AM1
Nakamura, KT3
Robillard, JE3
Jose, PA1
Andrushchenko, EV1
Chmir, VP1
Krasovskaia, EA1
Malanchuk, TA1
Polishchuk, II1
Iashchenko, OB1
Lou, JS1
Jankovic, J1
Fujita, S1
Ishida, R1
Obara, S1
Kitani, K1
Suzuki, T1
Schmidlin, O1
Nicholson, PA1
Karim, A1
Smith, M1
Frolkis, VV1
Gorban, EN1
Moroz, EV1
Kawano, K1
Thornhill, J1
Halvorson, I1
Eriksson, L1
Vynckier, LJ1
Rosseel, MT1
Chauvelot-Moachon, L1
Mollace, V1
Pelaggi, T1
Nisticò, G1
Staessen, J1
Fagard, R1
Lijnen, P1
Rorive, G1
Amery, A1
Page, WV1
Sato, T2
Klinkefus, JM2
Marks, RG1
Hale, WE1
Moore, MT1
May, FE1
Mirels, L1
Kousvelari, E1
Smith, DJ1
McNamara, JP1
Iwamoto, K5
Watanabe, J5
Yonekawa, H1
Lipsitz, LA1
Marks, ER1
Koestner, J1
Jonsson, PV1
Wei, JY1
Greenblatt, DJ2
O'Rourke, MF1
Kelly, RP1
Avolio, AP1
Hayward, C1
Smith, FG1
Colangelo, P1
Chandler, M1
Blouin, R1
McNamara, P1
Cox, RH1
Tulenko, TN1
Borton, M1
Docherty, JR1
McNair, CL1
Hymer, TK1
Boland, SR1
Leon, M1
McCormack, J1
Gelband, H1
Villafañe, J1
Xu, H1
Stolfi, A2
Pickoff, AS2
Lo, M1
Su, DF1
Julien, C1
Cerutti, C1
Vincent, M1
Sassard, J1
Gusev, GP1
Skul'skiĭ, IA1
Khrusmaleva, RS1
Judes, C1
Helwig, JJ1
Bollack, C1
Mandel, P1
Araki, K1
Deguchi, N2
Sugiyama, H2
Ochs, HR1
Friedman, H1
Burstein, ES1
Locniskar, A1
Harmatz, JS1
Shader, RI1
Mustafa, MB1
Sidi, D1
Kuipers, JR1
Heymann, MA1
Rudolph, AM1
Aoyama, Y1
Lanfumey, L1
Adrien, J1
De Caprio, L1
Papa, M1
Acanfora, D1
Cuomo, S1
Vigorito, C1
Cicatiello, AM1
Canonico, V1
Gallucci, F1
Rengo, F1
Krall, JF1
Fernandez, EI1
Connelly-Fittingoff, M1
Tsujimoto, A1
Tsujimoto, G1
Kato, K1
Hashimoto, K1
De Blasi, A1
Fratelli, M1
Wielosz, M1
Lipartiti, M1
Witkowska, M1
Ordway, GA1
Kolta, MG1
Gerald, MC1
Wallace, LJ1
Bickford-Wimer, PC1
Parfitt, K1
Hoffer, BJ1
Freedman, R1
Lang, I1
Kurz, R1
Geyer, G1
Tragl, KH1
Hilakivi, LA1
Taira, T1
Hilakivi, I1
MacDonald, E1
Tuomisto, L1
Hellevuo, K1
Marcus, C1
Ehrén, H1
Bolme, P1
Arner, P1
Young, ML1
Fournier, A1
Hamra, M1
Danilo, P2
Rosen, MR2
Collier, TJ1
Gash, DM1
Sladek, JR1
Toda, N1
Okamura, T1
Miyazaki, M1
Satoh, M2
Wheeler, MA1
Housman, A1
Cho, YH1
Weiss, RM1
Spinelli, W1
Buchthal, SD1
Seal, DV1
Tonooka, M1
Kawashima, I1
Sakashita, M1
Yasuhara, H1
Sakamoto, K1
Owen, TL1
Byrne, NG1
Hirst, GD1
Large, WA1
Stanton, HC1
Mueller, RL1
Perkins, JP1
Moore, MM1
Fenyvesi, T1
Káldor, A1
Sebestyén, K1
Rothbaum, DA2
Shaw, DJ2
Russek, HI1
Weiss, B1
Strada, SJ1
Löffelholz, K1
Pappano, AJ1
Maggi, GC1
de Jong, W1
Lovenberg, W1
Sjoerdsma, A1
Sturkie, PD1
Chillseyzn, J1
Walker, JB1
Walker, JP1
Eisdorfer, C1
Nowlin, J1
Wilkie, F1
Cumming, GR1
Mir, GH1
Robelli, F1
De Vita, C1
Cadel, A1
Campbell, AG1
Dawes, GS1
Fishman, AP1
Hyman, AI1
Perks, AM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Wavelet Transform and Pharmacodynamic Analysis of Atropine and Propranolol Induced Changes in Human Heart Rate Variability[NCT00251602]Phase 124 participants (Actual)Interventional2003-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for propranolol and Aging

ArticleYear
Koschei the immortal and anti-aging drugs.
    Cell death & disease, 2014, Dec-04, Volume: 5

    Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Caloric Restriction; Exercise; Folklore; G

2014
Beta-adrenergic receptors: biochemical mechanisms of physiological regulation.
    Physiological reviews, 1984, Volume: 64, Issue:2

    Topics: Adenylyl Cyclases; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; A

1984
Sympathetic nervous system and aging in man.
    Endocrine reviews, 1980,Spring, Volume: 1, Issue:2

    Topics: Adolescent; Adrenal Medulla; Adult; Aged; Aging; Animals; Blood Pressure; Child; Circadian Rhythm; C

1980
[Most frequent causes for hand tremor in clinical practice].
    Orvosi hetilap, 1995, Oct-08, Volume: 136, Issue:41

    Topics: Aged; Aged, 80 and over; Aging; Female; Hand; Humans; Hypokinesia; Male; Parkinson Disease; Posture;

1995
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:3

    Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Fem

1976
The application of clearance concepts to propranolol disposition in man.
    Drug metabolism reviews, 1979, Volume: 10, Issue:1

    Topics: Aging; Half-Life; Humans; Liver; Liver Diseases; Models, Biological; Propranolol; Smoking; Time Fact

1979
Aging and the extrapyramidal system.
    The Medical clinics of North America, 1976, Volume: 60, Issue:6

    Topics: Aged; Aging; Basal Ganglia Diseases; Chlorpromazine; Chorea; Dopamine; Frontal Lobe; Gait; Haloperid

1976
Plasma and tissue protein binding of drugs in pharmacokinetics.
    Drug metabolism reviews, 1976, Volume: 5, Issue:1

    Topics: Adrenal Cortex Hormones; Age Factors; Aging; Albumins; Animals; Anti-Bacterial Agents; Antibodies; A

1976
Disposition of cardiovascular drugs in the elderly.
    The Medical clinics of North America, 1989, Volume: 73, Issue:2

    Topics: Aged; Aging; Cardiovascular Agents; Humans; Propranolol

1989
Effects of arterial dilator agents on central aortic systolic pressure and on left ventricular hydraulic load.
    The American journal of cardiology, 1989, Jun-05, Volume: 63, Issue:19

    Topics: Adult; Aging; Aorta; Blood Pressure; Blood Pressure Determination; Brachial Artery; Hemodynamics; Hu

1989

Trials

16 trials available for propranolol and Aging

ArticleYear
Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.
    Journal of applied physiology (Bethesda, Md. : 1985), 2013, Oct-01, Volume: 115, Issue:7

    Topics: Aged; Aging; Arterial Pressure; Biopterins; Cross-Over Studies; Double-Blind Method; Female; Humans;

2013
β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.
    American journal of physiology. Heart and circulatory physiology, 2014, Nov-15, Volume: 307, Issue:10

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aging; Coronary Ves

2014
Age- and limb-related differences in the vasoconstrictor response to limb dependency are not mediated by a sympathetic mechanism in humans.
    Acta physiologica (Oxford, England), 2012, Volume: 205, Issue:3

    Topics: Adrenergic Antagonists; Adult; Aged; Aging; Arm; Blood Pressure; Brachial Artery; Female; Heart Rate

2012
Pharmacokinetics of SL 75212 and propranolol in old age, uraemia and in healthy young adults [proceedings].
    British journal of clinical pharmacology, 1980, Volume: 9, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Betaxolol; Female; Humans; Male; Propanolamines; Pr

1980
Beta-blocker prophylaxis after myocardial infarction.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Jun-06, Volume: 59, Issue:24

    Topics: Aging; Clinical Trials as Topic; Double-Blind Method; Humans; Myocardial Infarction; Placebos; Propa

1981
Effects of age and smoking on the pharmacokinetics of pindolol and propranolol.
    British journal of clinical pharmacology, 1982, Volume: 13, Issue:Suppl 2

    Topics: Adult; Aged; Aging; Female; Humans; Kinetics; Male; Middle Aged; Pindolol; Propranolol; Smoking; Tim

1982
Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans.
    The American journal of physiology, 1995, Volume: 268, Issue:4 Pt 2

    Topics: Adult; Aging; Atrioventricular Node; Atropine; Autonomic Nerve Block; Cardiac Pacing, Artificial; El

1995
Pharmacokinetics of fluvastatin and specific drug interactions.
    American journal of hypertension, 1993, Volume: 6, Issue:11 Pt 2

    Topics: Adolescent; Adult; Aged; Aging; Biological Availability; Cholestyramine Resin; Diet; Digoxin; Dose-R

1993
The lack of effect of aerobic exercise training on propranolol pharmacokinetics in young and elderly adults.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:9

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Chromatogr

1995
Influence of aging on the oxidative and conjugative metabolism of propranolol.
    International journal of clinical pharmacology research, 1995, Volume: 15, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Female; Half-

1995
Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:9

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Adult; Aged; Aging; Body Mass Inde

2001
Hemodynamic and plasma atrial natriuretic factor responses to cardiac volume loading in young versus older normotensive humans.
    Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:12

    Topics: Adult; Aging; Atrial Natriuretic Factor; Cardiac Output; Central Venous Pressure; Double-Blind Metho

1992
Double-blind comparison of ketanserin and propranolol in hypertensive patients.
    Journal of cardiovascular pharmacology, 1988, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Body Weight; Chromatography, High

1988
Reduced susceptibility to syncope during postural tilt in old age. Is beta-blockade protective?
    Archives of internal medicine, 1989, Volume: 149, Issue:12

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Disease Susceptibility; Forearm;

1989
Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes.
    Journal of gerontology, 1989, Volume: 44, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Electrocardiography; Female; Heart; Humans; Male;

1989
Improvement of learning in the aged by modification of autonomic nervous system activity.
    Science (New York, N.Y.), 1970, Dec-18, Volume: 170, Issue:3964

    Topics: Aged; Aging; Clinical Trials as Topic; Humans; Male; Middle Aged; Placebos; Propranolol; Sympathetic

1970

Other Studies

236 other studies available for propranolol and Aging

ArticleYear
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
    Neurobiology of aging, 2021, Volume: 106

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Clenbuterol; Cognitive Dysfun

2021
Adrenoceptors in Dopaminergic Regulation of Rat Myocardial Contractility in Rats During Ontogeny.
    Bulletin of experimental biology and medicine, 2017, Volume: 162, Issue:6

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Outbred Strains;

2017
Implications of aging in the treatment of complex arrhythmias.
    Aging, 2018, 10-27, Volume: 10, Issue:11

    Topics: Aging; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Metoprolol; Propranolol

2018
β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling.
    American journal of physiology. Heart and circulatory physiology, 2014, Volume: 306, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Blood Pressure; Body Temperature; Body Temperature

2014
Effects of lifestyle changes and high-dose β-blocker therapy on exercise capacity in children, adolescents, and young adults with hypertrophic cardiomyopathy.
    Cardiology in the young, 2015, Volume: 25, Issue:3

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aging; Blood Pressure; Cardiomyopathy, Hypertrophic,

2015
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.
    Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Embryonic Development; Female; Fertilization in Vitro; Fluorescent

2015
Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling.
    Neuropharmacology, 2015, Volume: 97

    Topics: Aging; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Central Nervous System Depressants;

2015
Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control.
    The Journal of physiology, 2016, 09-01, Volume: 594, Issue:17

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aging; Blood Pressure; Female; Humans; Male; M

2016
Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system.
    The Journal of endocrinology, 2017, Volume: 232, Issue:1

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Female; Gene Expression Regulation; Kisspeptins; Ovary;

2017
Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age.
    Neurobiology of learning and memory, 2009, Volume: 92, Issue:3

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Association Learning; Cerebellum; Conditioning, Eyelid;

2009
Role of {alpha}1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult;

2009
Periodic variation in R-R intervals and cardiovascular autonomic regulation in young adult Syrian hamsters.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Anti-Arrhythmia Agents; Atrop

2009
Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans.
    The Journal of physiology, 2009, Aug-01, Volume: 587, Issue:Pt 15

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Aging; Biopterins; Body Temp

2009
Presynaptic interneuron subtype- and age-dependent modulation of GABAergic synaptic transmission by beta-adrenoceptors in rat insular cortex.
    Journal of neurophysiology, 2010, Volume: 103, Issue:5

    Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Cerebral Cor

2010
[Ischemic heart disease in elderly patients of behavioral type A (psychosocial and clinic functional changes, possibilities for correction)].
    Advances in gerontology = Uspekhi gerontologii, 2011, Volume: 24, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Anti-Anxiety Agents; Behavioral Symptoms; Benzodiaz

2011
Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.
    The Journal of endocrinology, 2012, Volume: 213, Issue:3

    Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Cells, Cul

2012
Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model.
    Neuropharmacology, 2013, Volume: 64

    Topics: Adrenergic beta-Antagonists; Aging; Amyloid Neuropathies; Animals; Antihypertensive Agents; Biomarke

2013
Different effects of acute clenbuterol on vasomotor response in mesenteric arteries from young and old spontaneously hypertensive rats.
    European journal of pharmacology, 2003, Apr-18, Volume: 466, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aging; Animals; Blood Pressure; Calcitonin G

2003
Aging accelerates dietary lard-induced increase in blood pressure in rats.
    Experimental gerontology, 2003, Volume: 38, Issue:8

    Topics: Aging; Animals; Blood Glucose; Dietary Fats; Epinephrine; Glucose; Hypertension; Insulin; Insulin Re

2003
Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Adr

2004
Effect of beta-adrenoceptor blockade on cardiac activity in rats during postnatal ontogeny.
    Bulletin of experimental biology and medicine, 2003, Volume: 136, Issue:3

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Body Weight; Electrophysiology; Femoral Vein; Heart Rat

2003
Age-dependent morphometrical changes in the thymus of male propranolol-treated rats.
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2004, Volume: 186, Issue:2

    Topics: Aging; Animals; Connective Tissue; Male; Organ Size; Propranolol; Rats; Sexual Maturation; Thymus Gl

2004
Do incremental increases in blood pressure elicit neointimal plaques through endothelial injury?
    American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 287, Issue:6

    Topics: Aging; Animals; Aorta, Abdominal; Arginine; Blood Pressure; Chickens; Disease Models, Animal; Endoth

2004
Age-related differences in the response of blood stroke volume to stimulation of the sympathetic ganglion in rats with beta-adrenoceptor blockade.
    Bulletin of experimental biology and medicine, 2004, Volume: 138, Issue:4

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Cardiac Output; Propranolol; Rats; Receptors, Adrenergi

2004
Beta blockers for the treatment of primary hypertension.
    Lancet (London, England), 2006, Jan-21, Volume: 367, Issue:9506

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Humans; Hypertension; Middle Aged; Myocardial Infar

2006
Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2006, Volume: 42, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Dose-Respo

2006
[Characteristics of arrhythmia in elderly patients].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2006, Volume: 43, Issue:6

    Topics: Aged; Aging; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Diagnosis, Different

2006
Neural plasticity maintained high by activation of cyclic AMP-dependent protein kinase: an age-independent, general mechanism in cat striate cortex.
    Neuroscience, 2007, Jun-29, Volume: 147, Issue:2

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Brain Mapping; Bucladesine; Cats; Cholera Toxin; Cyclic

2007
Depressed cardiac contractility and its postnatal development in rats after chemical sympathectomy.
    Physiological research, 2008, Volume: 57, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Myocardial

2008
Age-related changes of in vivo beta-adrenergic responsiveness in normotensive and spontaneously hypertensive rats.
    European journal of pharmacology, 1984, Jun-15, Volume: 102, Issue:1

    Topics: Aging; Animals; Blood Pressure; Cyclic AMP; Hypertension; Isoproterenol; Male; Propranolol; Rats; Ra

1984
Distribution and quantitative developmental changes in guinea pig pulmonary beta-receptors.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1984, Volume: 57, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding Sites; Dihydroalprenolol; Guinea Pigs; Lu

1984
Influence of smoking and age on pharmacokinetics of beta-receptor blockers.
    Gerontology, 1982, Volume: 28 Suppl 1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Humans; Kinetics; Male; Middle Aged; Pindolol; Prop

1982
Potassium homeostasis during hyperinsulinemia: effect of insulin level, beta-blockade, and age.
    The American journal of physiology, 1982, Volume: 242, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Homeostasis; Humans; Insulin; Male; Middle Aged; Po

1982
The natural history of left ventricular hypertrophy in hypertrophic cardiomyopathy: an electrocardiographic study.
    Circulation, 1982, Volume: 66, Issue:6

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aging; Angina Pectoris; Cardiomyopathy, Hypertrophic

1982
Selected phenotypic induction of null lymphocytes from mice with thymic and nonthymic agents.
    Cellular immunology, 1982, Sep-01, Volume: 72, Issue:1

    Topics: Aging; Animals; Antigens, Surface; Cell Differentiation; Chromosomal Proteins, Non-Histone; Cyclic A

1982
Beta-adrenergic regulation of rat parotid gland exocrine protein secretion during aging.
    Mechanisms of ageing and development, 1981, Volume: 15, Issue:2

    Topics: Aging; Amylases; Animals; Dihydroalprenolol; Dose-Response Relationship, Drug; In Vitro Techniques;

1981
Secretion of alpha-amylase from parotid lobules of young and old rats.
    Experimental gerontology, 1982, Volume: 17, Issue:5

    Topics: Aging; Amylases; Animals; Isoproterenol; Male; Microscopy, Electron; Parotid Gland; Propranolol; Rat

1982
Is the modality of the supersensitivity after sympathectomy age and duration dependent?
    Neuroscience letters, 1984, Apr-06, Volume: 45, Issue:3

    Topics: Aging; Amylases; Animals; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Norepinephrine; Pa

1984
Effect of clenbuterol, a new beta 2 selective adrenoceptor stimulant, on the release of histamine and SRS-A from passively sensitized guinea-pig chopped lungs.
    General pharmacology, 1984, Volume: 15, Issue:4

    Topics: Aging; Albuterol; Animals; Chromones; Clenbuterol; Ethanolamines; Guinea Pigs; Histamine Release; In

1984
Human lymphocyte beta-adrenergic receptors are unaltered with age.
    Journal of gerontology, 1981, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Dihydroalprenolol; Epinephrine; Female; Humans; Isoproterenol; Lymph

1981
Adenylate cyclase and beta adrenergic receptor development in the mouse heart.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:1

    Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Dihydroalprenolol; Female; Fetal Heart; Heart;

1982
Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats.
    The Journal of biological chemistry, 1983, Apr-25, Volume: 258, Issue:8

    Topics: Aging; Animals; Cyclic AMP; Epinephrine; Isoproterenol; Liver; Male; Prazosin; Propranolol; Rats; Ra

1983
Beta-adrenergic control of phosphatidylcholine synthesis by transmethylation in hepatocytes from juvenile, adult and adrenalectomized rats.
    The Biochemical journal, 1983, Dec-15, Volume: 216, Issue:3

    Topics: Adrenalectomy; Aging; Animals; Cyclic AMP; Ethanolamines; In Vitro Techniques; Insulin; Isoprotereno

1983
Beta-1 and beta-2 adrenoceptor-mediated responses in preparations of pulmonary artery and aorta from young and aged rats.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:3

    Topics: Aging; Animals; Aorta; Cocaine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Tec

1984
Effect of age and diet on insulin secretion and insulin action in the rat.
    Diabetes, 1983, Volume: 32, Issue:2

    Topics: Aging; Animals; Dietary Carbohydrates; Epinephrine; Glucose; Glucose Tolerance Test; Hyperplasia; In

1983
Effect of propranolol treatment in pregnant rats on motor activity and avoidance learning of the offspring.
    Psychopharmacology, 1983, Volume: 79, Issue:2-3

    Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Female; Fetal Hypoxia; Male; Motor Activity; P

1983
Insulin resistance in older rats.
    The American journal of physiology, 1984, Volume: 246, Issue:5 Pt 1

    Topics: Aging; Animals; Blood Glucose; Body Composition; Epinephrine; Glycogen; Glycogen Synthase; Hindlimb;

1984
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.
    British journal of pharmacology, 1982, Volume: 75, Issue:3

    Topics: Aging; Airway Resistance; Animals; Bronchi; Cimetidine; Dimaprit; Female; Guanidines; Guinea Pigs; H

1982
Noradrenergic influences on blocking: interactions with development.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:1

    Topics: Aging; Animals; Attention; Avoidance Learning; Conditioning, Operant; Female; Growth; Isoproterenol;

1984
[Endogenous opioid peptides in borderline arterial hypertension].
    Klinicheskaia meditsina, 1984, Volume: 62, Issue:11

    Topics: Adolescent; Adult; Aging; Endorphins; Female; Hemodynamics; Humans; Hypertension; Male; Propranolol;

1984
An investigation of the age-related deficits in the febrile response of the rabbit.
    The American journal of physiology, 1983, Volume: 245, Issue:3

    Topics: Aging; Animals; Body Temperature; Body Temperature Regulation; Endotoxins; Fever; Kinetics; Norepine

1983
Influence of age on serum protein binding of propranolol.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Child; Humans; Male; Orosomucoid; Propranolol; Prote

1984
Does insulin removal rate from plasma decline with age?
    Diabetes, 1982, Volume: 31, Issue:8 Pt 1

    Topics: Adult; Aged; Aging; Animals; Epinephrine; Humans; Insulin; Male; Metabolic Clearance Rate; Middle Ag

1982
Plasma triiodothyronine response to thyrotropin releasing hormone, thyrotropin and propranolol in old age.
    Experimental gerontology, 1981, Volume: 16, Issue:4

    Topics: Adult; Aged; Aging; Female; Humans; Male; Propranolol; Thyrotropin; Thyrotropin-Releasing Hormone; T

1981
Thermoregulatory heat production in cold-reared and warm-reared pigs.
    The American journal of physiology, 1983, Volume: 244, Issue:2

    Topics: Acclimatization; Aging; Animals; Body Temperature Regulation; Cold Temperature; Hot Temperature; Nor

1983
Sympathetic regulation of circadian rhythm of serotonin N-acetyltransferase activity in pineal gland of infant rat.
    Journal of neurochemistry, 1982, Volume: 38, Issue:3

    Topics: Acetyltransferases; Aging; Animals; Animals, Newborn; Arylamine N-Acetyltransferase; Circadian Rhyth

1982
The comparative hemodynamic effects of propranolol in chronically instrumented puppies and adult dogs.
    Biology of the neonate, 1982, Volume: 41, Issue:1-2

    Topics: Aging; Animals; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Hemodynamics; Isoproterenol; Kidne

1982
Age-related changes in pineal "synaptic" ribbon populations in rats exposed to continuous light or darkness.
    The American journal of anatomy, 1982, Volume: 163, Issue:2

    Topics: Aging; Animals; Darkness; Female; Isoproterenol; Light; Pineal Gland; Propranolol; Rats; Time Factor

1982
The influences of glucagon, epinephrine and adrenergic agents on glycogen phosphorylase a and pyruvate kinase activities in hepatocytes from juvenile and adult rabbits.
    Biochimica et biophysica acta, 1982, Jul-16, Volume: 717, Issue:1

    Topics: Aging; Animals; Epinephrine; Glucagon; Isoproterenol; Liver; Male; Phentolamine; Phenylephrine; Phos

1982
Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Clonidine; Digitoxin; Drug Interactions; Gait; Male; Mice; Postura

1982
The rise and fall of pineal N-acetyltransferase in vitro: neural regulation in the developing rat.
    Journal of neurobiology, 1982, Volume: 13, Issue:6

    Topics: Acetyltransferases; Aging; Animals; Circadian Rhythm; Ganglia, Sympathetic; Light; Muridae; Neural P

1982
The possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people.
    Acta medica Academiae Scientiarum Hungaricae, 1982, Volume: 39, Issue:1-2

    Topics: Adult; Aged; Aging; Female; Humans; Kinetics; Male; Propranolol; Thyrotropin; Thyroxine; Triiodothyr

1982
Cardiovascular drugs for the geriatric patient.
    Geriatrics, 1981, Volume: 36, Issue:8

    Topics: Aged; Aging; Antihypertensive Agents; Cardiovascular Agents; Cardiovascular Physiological Phenomena;

1981
Role of aortic input impedance in the decreased cardiovascular response to exercise with aging in dogs.
    The Journal of clinical investigation, 1981, Volume: 68, Issue:1

    Topics: Aging; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dogs; Electric Conductiv

1981
Ouabain-induced inotropism of isolated newborn and adult rabbit myocardium.
    Developmental pharmacology and therapeutics, 1981, Volume: 2, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Heart; In Vitro Techniques; Myocardial Contr

1981
Propranolol-induced alterations in the pathophysiology of spontaneously hypertensive rats.
    Life sciences, 1981, Oct-05, Volume: 29, Issue:14

    Topics: Aging; Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Corticosterone; F

1981
Evidences supporting an increased sympathetic tone and reactivity in a subgroup of patients with essential hypertension.
    Clinical and experimental hypertension, 1980, Volume: 2, Issue:3-4

    Topics: Adult; Aging; Blood Pressure; Catecholamines; Diagnosis, Differential; Epinephrine; Female; Heart Ra

1980
Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant.
    Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:4

    Topics: Adult; Aging; Blood Proteins; Contraceptives, Oral; Diazepam; Female; Humans; Infant, Newborn; Lidoc

1981
Nitric oxide and beta-adrenergic mechanisms modify contractile responses to norepinephrine in ovine fetal and newborn cerebral arteries.
    Pediatric research, 1995, Volume: 38, Issue:2

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Arginine; Cerebral Arteries; Embryoni

1995
[Changes in the number of alpha 2- and beta-adrenoreceptors in the brain stem and cerebral cortex of rats in ontogeny].
    Fiziologicheskii zhurnal imeni I.M. Sechenova, 1995, Volume: 81, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Brain Chemistry; Brain Stem;

1995
Developmental changes of action potential configuration and I(to) in canine epicardium.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2

    Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Cells, Cultured; Dogs; Fetus; Heart; Patch-Clamp

1995
Effect of ageing and propranolol administration on myocardial beta-adrenoceptor receptor function in mature rats.
    European journal of pharmacology, 1995, Apr-28, Volume: 289, Issue:2

    Topics: Age Factors; Aging; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Heart; Isoproterenol; Mal

1995
Systolic functional response of normal older and younger adult left ventricles to beta-blockade during exercise.
    Cardiovascular drugs and therapy, 1995, Volume: 9, Issue:2

    Topics: Adult; Aged; Aging; Blood Pressure; Echocardiography; Electrocardiography; Exercise; Exercise Test;

1995
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
    British journal of pharmacology, 1995, Volume: 114, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine;

1995
The effect of different calcium antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes.
    Fundamental & clinical pharmacology, 1994, Volume: 8, Issue:4

    Topics: Aging; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Drug Interactions; Liver; Male;

1994
Influence of autonomic blockade and aging on AV conduction and responses to verapamil in the beagle.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:2

    Topics: Aging; Animals; Atrioventricular Node; Atropine; Autonomic Nervous System; Blood Pressure; Dogs; Dos

1995
Norepinephrine and posttraining memory consolidation in neonatal rats.
    Behavioral neuroscience, 1994, Volume: 108, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Appetitive Behavior; Association Learning; Brain; Conditioning, Cl

1994
Effects of acute beta-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise.
    Circulation, 1994, Volume: 90, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Exercise; Hemodynamics; Humans;

1994
Increased alpha 2-adrenoceptor mediated regulation of adult rat brain noradrenaline overflow after chronic neonatal exposure to propranolol; a microdialysis study.
    Brain research, 1994, May-16, Volume: 646, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Biogenic Monoamines; Brain; Methoxyhydroxyphenylglycol; Microdialy

1994
Norepinephrine-induced relaxations in rat aorta mediated by endothelial beta adrenoceptors. Impairment by ageing and hypertension.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:2

    Topics: Aging; Animals; Aorta; Arginine; Endothelium, Vascular; Hypertension; In Vitro Techniques; Isoproter

1994
Alpha-2 adrenergic receptor activity in porcine adipocytes is androgen and age/cell size dependent.
    Comparative biochemistry and physiology. Comparative physiology, 1993, Volume: 105, Issue:2

    Topics: Adipose Tissue; Aging; Androgens; Animals; Cell Size; Epinephrine; Isoproterenol; Lipolysis; Male; P

1993
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes.
    The Journal of biological chemistry, 1994, Jun-17, Volume: 269, Issue:24

    Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Carbachol; Cell Membrane; Cells, Cultured; Cyto

1994
The effect of propranolol on salivary gland function and dental caries development in young and aged rats.
    Archives of oral biology, 1993, Volume: 38, Issue:10

    Topics: Aging; Alveolar Bone Loss; Animals; Dental Caries; Dental Caries Susceptibility; Dental Plaque; Diet

1993
Nonlinearity of the left ventricular end-systolic wall stress-velocity of fiber shortening relation in young pigs: a potential pitfall in its use as a single-beat index of contractility.
    Journal of the American College of Cardiology, 1994, Volume: 23, Issue:2

    Topics: Aging; Animals; Dobutamine; Echocardiography; Heart Rate; Hemodynamics; Linear Models; Myocardial Co

1994
Changes in alpha 1-adrenoceptor coupling to Ca2+ channels during development in rat heart.
    FEBS letters, 1994, Jan-31, Volume: 338, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Calcium Channels; Electric Conductivity; Heart; Membrane Potential

1994
Cardiovascular hyporesponsiveness to norepinephrine, propranolol and nitroglycerin in portal-hypertensive and aged rats.
    Hepatology (Baltimore, Md.), 1993, Volume: 18, Issue:1

    Topics: Aging; Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate;

1993
Age-related changes of sinus node function and autonomic regulation in subjects without sinus node disease--assessment by pharmacologic autonomic blockade.
    Japanese circulation journal, 1993, Volume: 57, Issue:8

    Topics: Adolescent; Adult; Aged; Aging; Atropine; Autonomic Nerve Block; Autonomic Nervous System; Electroph

1993
Assessment of 8-OH-DPAT induced spontaneous tailflicks as an in vivo model of 5-HT1A function in young rats.
    Neuropharmacology, 1993, Volume: 32, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Res

1993
Effects of age on beta-adrenergic-mediated reflex responses to induced muscular contraction in beagles.
    Mechanisms of ageing and development, 1993, Volume: 68, Issue:1-3

    Topics: Aging; Animals; Cardiovascular System; Dogs; Hemodynamics; Muscle Contraction; Propranolol; Receptor

1993
Influence of human recombinant interleukin-1 beta on the enantioselective disposition of propranolol in rats.
    Biochemical pharmacology, 1993, Jan-07, Volume: 45, Issue:1

    Topics: Aging; Animals; Humans; Interleukin-1; Kinetics; Male; Propranolol; Rats; Rats, Wistar; Recombinant

1993
Lymphocyte norepinephrine and epinephrine, but not plasma catecholamines predict lymphocyte cAMP production.
    Life sciences, 1996, Volume: 59, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Aged, 80 and over; Aging; Cyclic AMP; Epinephrine; Humans;

1996
Differential adrenergic regulation of rat pineal cyclic AMP production and N-acetyltransferase activity during postnatal development: involvement of G alpha s and G alpha i1-2 proteins.
    The Journal of endocrinology, 1997, Volume: 155, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; An

1997
The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart.
    British journal of pharmacology, 1998, Volume: 123, Issue:4

    Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; GTP-Binding P

1998
Reduced DNA synthesis in primary cultures of hepatocytes from old mice is restored by thymus grafts.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1998, Volume: 53, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Blood Physi

1998
Beta-adrenoceptor-stimulated renin release is blunted in old rats.
    Journal of the American Society of Nephrology : JASN, 1998, Volume: 9, Issue:7

    Topics: Aging; Animals; Disease Models, Animal; Male; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Ad

1998
Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats.
    Journal of lipid research, 1973, Volume: 14, Issue:3

    Topics: Adipocytes; Adrenocorticotropic Hormone; Aging; Animals; Dose-Response Relationship, Drug; Epinephri

1973
Diabetic alteration of cardiac vago-sympathetic modulation assessed with tone-entropy analysis.
    Acta physiologica Scandinavica, 1999, Volume: 165, Issue:2

    Topics: Adult; Aged; Aging; Atropine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 2; Electrocar

1999
Aging alteration of cardiac vagosympathetic balance assessed through the tone-entropy analysis.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1999, Volume: 54, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Atropine; Autonomic Nervous System; Efferent Pathwa

1999
[Cardial output in rats of various ages during blocking of alpha1- and beta-adrenoreceptors].
    Biulleten' eksperimental'noi biologii i meditsiny, 1999, Volume: 127, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists;

1999
Developmental and pharmacological features of mouse emotional piloerection.
    Experimental animals, 1999, Volume: 48, Issue:3

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Behavior, Animal; Conditioning, Classical; Diazepam; E

1999
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
    Circulation, 2001, Feb-13, Volume: 103, Issue:6

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Aging; Animals; Calcium-Binding Proteins; Cardiomyop

2001
Effects of L-phenylalanine on acetylcholinesterase and Na(+), K(+)-ATPase activities in adult and aged rat brain.
    Mechanisms of ageing and development, 2001, Apr-30, Volume: 122, Issue:5

    Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Bra

2001
Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the changes with aging.
    The Prostate, 2001, Jun-15, Volume: 48, Issue:1

    Topics: Aging; Aminoquinolines; Animals; Arginine; Atropine; Electric Stimulation; Guanethidine; Histocytoch

2001
Aging alters neuronal nitric oxide release from rat mesenteric arteries: role of presynaptic beta-adrenoceptors.
    Clinical science (London, England : 1979), 2001, Volume: 101, Issue:4

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Clenbuterol; Culture Techniqu

2001
Influence of age, the autonomic nervous system and anxiety on QT-interval variability.
    Clinical science (London, England : 1979), 2001, Volume: 101, Issue:4

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Analysis of Variance; Anti-Arrhythmia Agents; Anxie

2001
Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction.
    The Journal of physiology, 2001, Nov-01, Volume: 536, Issue:Pt 3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Aging; Blood Pressure; Body

2001
Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:3

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Body Fluids; Body Water; Catecholamin

2002
Effects of neurotransmitters and neuropharmacological agents on phospholipid metabolism in the rabbit iris muscle.
    Advances in experimental medicine and biology, 1976, Volume: 72

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Atropine; Ca

1976
Beta-adrenergic receptor blocking drugs in spontaneous hypertension.
    The American journal of medicine, 1976, Volume: 61, Issue:5

    Topics: Adrenergic beta-Antagonists; Aging; Alprenolol; Animals; Blood Pressure; Hypertension; Male; Metopro

1976
Age-dependent response of neonate fowls to peripheral noradrenaline.
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1976, Volume: 55, Issue:2

    Topics: Adrenal Glands; Aging; Animals; Animals, Newborn; Body Temperature; Chickens; Epinephrine; Male; Nor

1976
[Essential hypertension: adrenergic control system, renin-angiotensin effector axis, kidney and age].
    Schweizerische medizinische Wochenschrift, 1976, Dec-11, Volume: 106, Issue:50

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Angiotensin II; Catecholamines; Diuretics; Humans;

1976
Renin and age as determinants of a predominantly betablocker-based antihypertensive drug program.
    Advances in nephrology from the Necker Hospital, 1976, Volume: 6

    Topics: Adrenergic beta-Antagonists; Adult; Aging; Aldosterone; Angiotensin II; Antihypertensive Agents; Blo

1976
Identification of beta adrenoreceptors during thymocyte ontogeny in mice.
    European journal of immunology, 1979, Volume: 9, Issue:1

    Topics: Adrenergic beta-Agonists; Aging; Alprenolol; Animals; Binding Sites; Cyclic AMP; Cyclic GMP; Hydroge

1979
Use of drugs in the aged.
    The Johns Hopkins medical journal, 1979, Volume: 145, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Analgesics, Opioid; Benzodiazepines; Digoxin; Drug Therapy; Drug-Rel

1979
Adrenergic control of glucose output and adenosine 3':5'-monophosphate levels in hepatocytes from juvenile and adult rats.
    The Journal of biological chemistry, 1979, Aug-25, Volume: 254, Issue:16

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Cyclic AMP; Epinephrine;

1979
Effects of beta-adrenoreceptor antagonists on sino-aortic baroreflex sensitivity and blood pressure in hypertensive man.
    Clinical science (London, England : 1979), 1979, Volume: 57, Issue:3

    Topics: Acebutolol; Adolescent; Adrenergic beta-Agonists; Adult; Aging; Blood Pressure; Female; Heart Rate;

1979
Medical management of angina pectoris.
    Angiology, 1979, Volume: 30, Issue:10

    Topics: Aging; Angina Pectoris; Arteriosclerosis; Coronary Disease; Diet; Humans; Hypnotics and Sedatives; N

1979
Postnatal development of postganglionic parasympathetic neurones in the heart of the albino rat.
    Physiologia Bohemoslovaca, 1979, Volume: 28, Issue:6

    Topics: Acetylcholine; Action Potentials; Aging; Animals; Cholinesterase Inhibitors; Depression, Chemical; E

1979
[Dynamics of plasma catecholamines and beta-adrenoreceptor functions. Use of a new radio-enzymatic micro-method].
    Schweizerische medizinische Wochenschrift, 1976, Dec-04, Volume: 106, Issue:49

    Topics: Adult; Aging; Blood Pressure; Catecholamines; Dopamine; Epinephrine; Female; Humans; Male; Middle Ag

1976
Airway response to adrenergic agonists and antagonists in 3-day- to 2-year-old rats.
    Respiration; international review of thoracic diseases, 1979, Volume: 38, Issue:2

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Atropine; Bronchi; Bronchitis; Epinephrine; Female;

1979
Noradrenaline secretion by the human kidney.
    Clinical science and molecular medicine. Supplement, 1978, Volume: 4

    Topics: Aging; Aldosterone; Blood Pressure; Humans; Hypertension; Kidney; Norepinephrine; Propranolol; Renin

1978
Effects of age and cigarette smoking on propranolol disposition.
    Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aging; Half-Life; Humans; Kinetics; Liver; Male; Middle Aged; Pro

1979
Adrenergic control of glycolysis and pyruvate kinase activity in hepatocytes from young and old rats.
    The Journal of biological chemistry, 1979, Aug-25, Volume: 254, Issue:16

    Topics: Aging; Animals; Epinephrine; Glucagon; Glucose; Glycolysis; In Vitro Techniques; Isoproterenol; Lact

1979
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins.
    Life sciences, 1979, Dec-03, Volume: 25, Issue:23

    Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I

1979
[Nervous regulation of cardiac function during aging].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1977, Volume: 63, Issue:8

    Topics: Acetylcholine; Aging; Animals; Atropine; Cardiac Output; Cats; Choline O-Acetyltransferase; Electric

1977
Progressive postnatal changes in sinus node response to atropine and propranolol.
    The American journal of physiology, 1978, Volume: 234, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Atropine; Depression, Chemical; Dogs; Heart Rate; Propranolol; Sin

1978
Cardiac output changes during neonatal growth.
    The American journal of physiology, 1978, Volume: 234, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Atropine; Cardiac Output; Female; Heart Rate; Isoproterenol; Propr

1978
The effect of age and hyperthyroidism on plasma propranolol steady state concentration [proceedings].
    British journal of clinical pharmacology, 1978, Volume: 6, Issue:5

    Topics: Aging; Humans; Hyperthyroidism; Propranolol

1978
Age-associated decrease in ventricular response to haemodynamic stress during beta-adrenergic blockade.
    British heart journal, 1978, Volume: 40, Issue:12

    Topics: Adolescent; Adult; Aged; Aging; Blood Pressure; Heart; Heart Ventricles; Humans; Isometric Contracti

1978
The effect of ageing on the hepatic clearance of propranolol.
    British journal of clinical pharmacology, 1979, Volume: 7, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Female; Half-Life; Humans; Inject

1979
Tissue lipoprotein lipase in the hyperthyroid rat. Effect of growth and aging.
    Atherosclerosis, 1977, Volume: 26, Issue:3

    Topics: Adipose Tissue; Aging; Animals; Body Weight; Diaphragm; Fasting; Female; Heart; Hyperthyroidism; Lip

1977
Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:3

    Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Chlorisondami

1977
Maximum exercise heart rate reduction with maturation in the rat.
    Journal of applied physiology, 1976, Volume: 40, Issue:5

    Topics: Aging; Animals; Atropine; Electric Stimulation; Heart; Heart Rate; Male; Organ Size; Physical Exerti

1976
Dual effects of aspirin in guinea-pig lungs.
    British journal of pharmacology, 1976, Volume: 57, Issue:4

    Topics: Aging; Animals; Aspirin; Bronchi; Constriction, Pathologic; Female; Guinea Pigs; In Vitro Techniques

1976
Reinstatement of vaginal cycles in aged female rats.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:2

    Topics: Aging; Animals; Benserazide; Carbidopa; Dose-Response Relationship, Drug; Drug Interactions; Estrus;

1976
Clinical pharmacokinetics in infants and children.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:1

    Topics: Aging; Body Water; Carbamazepine; Child; Child, Preschool; Clindamycin; Dextropropoxyphene; Diazoxid

1976
Relationship between central and autonomic nervous system activity: correlates of psychomotor performance in elderly men.
    Experimental aging research, 1976, Volume: 2, Issue:5

    Topics: Aged; Aging; Arousal; Autonomic Nervous System; Central Nervous System; Contingent Negative Variatio

1976
Geriatric cardiovascular problems.
    AANA journal, 1976, Volume: 44, Issue:6

    Topics: Aged; Aging; Anesthesia; Arrhythmias, Cardiac; Blood Circulation; Cardiovascular Physiological Pheno

1976
Prolonged contraction duration in aged myocardium.
    The Journal of clinical investigation, 1975, Volume: 55, Issue:1

    Topics: Action Potentials; Aging; Animals; Catecholamines; Electric Stimulation; Heart; Hydroxydopamines; Hy

1975
Changes in cardiac membranes as a function of age with particular emphasis on reactivity to drugs.
    Advances in experimental medicine and biology, 1975, Volume: 61

    Topics: Action Potentials; Aging; Animals; Heart; Heart Conduction System; Heart Rate; Hydroxydopamines; In

1975
Changes in myocardial collagen in normal development and after beta blockade.
    Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 7

    Topics: Aging; Animals; Collagen; Fetus; Heart; Heart Ventricles; Myocardium; Organ Size; Practolol; Propran

1975
The effect of age on plasma levels of propranolol and practolol in man.
    British journal of clinical pharmacology, 1975, Volume: 2, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aging; Female; Half-Life; Humans; Male; Practolol; Propranolol

1975
Influence of animal age on the beta-adrenergic system in cultured rat aortic and mesenteric artery smooth muscle cells.
    Journal of gerontology, 1992, Volume: 47, Issue:2

    Topics: Aging; Alprostadil; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response

1992
Age and beta-adrenergic receptor sensitivity to S(-)- and R,S(+/-)-propranolol in humans.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Blood Pressure; Heart Rate; Humans; Isoprotereno

1992
Age-related delay in recovery of beta-adrenergic sensitivity after abrupt propranolol withdrawal in rats.
    Mechanisms of ageing and development, 1992, Mar-15, Volume: 63, Issue:1

    Topics: Aging; Animals; Blood Pressure; Drug Resistance; Epinephrine; Heart Rate; Male; Phenylephrine; Propr

1992
Influence of age on the beta 1- and beta 2-adrenergic receptors in rat liver.
    Molecular pharmacology, 1992, Volume: 42, Issue:4

    Topics: Adenylyl Cyclases; Aging; Animals; Binding, Competitive; Cell Membrane; Imidazoles; Liver; Liver Gly

1992
Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines.
    Endocrinology, 1992, Volume: 131, Issue:6

    Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Aging; Animals; Arginine Vasopressin; Cate

1992
[A comparative evaluation of the effect of anaprilin and teonikol on thrombocyte aggregation indices in patients with ischemic heart disease from older age groups].
    Terapevticheskii arkhiv, 1992, Volume: 64, Issue:10

    Topics: Adrenal Cortex Hormones; Aged; Aging; Drug Evaluation; Female; Humans; Male; Middle Aged; Myocardial

1992
Lack of effect of ageing on the stereochemical disposition of propranolol.
    British journal of clinical pharmacology, 1992, Volume: 33, Issue:1

    Topics: Adult; Aged; Aging; Humans; Liver Circulation; Male; Metabolic Clearance Rate; Propranolol; Stereois

1992
Age and propranolol stereoselective disposition in humans.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:5

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Humans; Male; Metabolic Cl

1992
Age and gender influence the stereoselective pharmacokinetics of propranolol.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aging; Blood Proteins; Female; Humans; Male; Orosomucoid; Propran

1992
The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat.
    Chirality, 1992, Volume: 4, Issue:2

    Topics: Administration, Oral; Aging; Animals; Hematocrit; Injections, Intravenous; Male; Propranolol; Rats;

1992
Effect of age on presynaptic beta2 receptor mediated responses in the rat heart.
    Mechanisms of ageing and development, 1991, Jun-14, Volume: 59, Issue:1-2

    Topics: Aging; Animals; Heart; Homeostasis; In Vitro Techniques; Male; Norepinephrine; Perfusion; Propranolo

1991
Amphetamine actions on pre- and postpubertal rat hippocampal dentate granule neurons.
    Brain research, 1991, Aug-09, Volume: 556, Issue:1

    Topics: Aging; Animals; Atenolol; Calcium Channels; Cocaine; Dextroamphetamine; Evoked Potentials; Haloperid

1991
Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.
    Brain research bulletin, 1991, Volume: 26, Issue:6

    Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Dopamine; Neurotoxins; Norepinephrine; Ornithine

1991
Effects of chronic administration of carteolol on beta-adrenoceptors in spontaneously hypertensive rat heart.
    Japanese journal of pharmacology, 1991, Volume: 56, Issue:4

    Topics: Aging; Animals; Binding Sites; Blood Pressure; Carteolol; Dihydroalprenolol; Heart Rate; Hypertensio

1991
Alterations in beta adrenergic and muscarinic receptors in aged rat heart. Effects of chronic administration of propranolol and atropine.
    Mechanisms of ageing and development, 1991, Volume: 60, Issue:2

    Topics: Aging; Animals; Atropine; Heart; Infusion Pumps, Implantable; Male; Myocardium; Propranolol; Rats; R

1991
[The characteristics of the tension of neurohumoral regulation during the physical loading of dogs].
    Doklady Akademii nauk SSSR, 1991, Volume: 318, Issue:3

    Topics: Aging; Animals; Clonidine; Dinoprostone; Dogs; Hormones; Male; Neurotransmitter Agents; Physical Exe

1991
Hepatic beta-adrenoceptor adaptation during propranolol administration is impaired in aging rats.
    European journal of pharmacology, 1991, Dec-12, Volume: 208, Issue:4

    Topics: Adaptation, Physiological; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists;

1991
Beta adrenergically mediated cardiac chronotropic and vascular smooth muscle responses during propranolol therapy and withdrawal in young and elderly persons.
    Journal of gerontology, 1992, Volume: 47, Issue:1

    Topics: Adult; Aged; Aging; Blood Pressure; Female; Heart Rate; Humans; Isoproterenol; Male; Muscle, Smooth,

1992
Effect of age on the kinetics of the binding of iodocyanopindolol to a membrane preparation of rat lungs.
    Journal of receptor research, 1991, Volume: 11, Issue:6

    Topics: Aging; Animals; In Vitro Techniques; Iodocyanopindolol; Lung; Pindolol; Propranolol; Rats; Temperatu

1991
Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 71, Issue:4

    Topics: Adult; Aging; Atropine; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Human

1991
Agonist-induced Ca2+ mobilization in the rat submandibular gland during aging and subsequent to chronic propranolol treatment.
    Mechanisms of ageing and development, 1991, Nov-15, Volume: 61, Issue:1

    Topics: Aging; Animals; Calcium; Carbachol; Female; In Vitro Techniques; Intracellular Fluid; Isoproterenol;

1991
Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries.
    Cardiovascular research, 1991, Volume: 25, Issue:12

    Topics: Aging; Animals; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothe

1991
Differential age-dependent attenuation of reflex tachycardia by verapamil in rats.
    Mechanisms of ageing and development, 1991, Volume: 58, Issue:2-3

    Topics: Aging; Animals; Atropine; Female; Heart Rate; Nitroprusside; Parasympathetic Nervous System; Phenyle

1991
Ontogeny of renal beta adrenoceptors in the sheep.
    Pediatric nephrology (Berlin, Germany), 1990, Volume: 4, Issue:6

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Binding, Competitive; Ethanol

1990
[Beta-adrenoblockaders and calcium antagonists in the treatment of patients with ischemic heart disease combined with hypertension].
    Vrachebnoe delo, 1990, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Calcium Channel Blockers; Coronary Disease; Drug Ev

1990
Essential tremor: clinical correlates in 350 patients.
    Neurology, 1991, Volume: 41, Issue:2 ( Pt 1)

    Topics: Adult; Aged; Aging; Alcohol Drinking; Female; Humans; Male; Middle Aged; Movement Disorders; Primido

1991
Hepatic microsomal propranolol metabolism in aging male and female rats.
    Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:2

    Topics: Aging; Animals; Dealkylation; Female; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; P

1991
Autonomic regulation of reflex bradycardia in rats declines with age.
    Experimental gerontology, 1991, Volume: 26, Issue:1

    Topics: Aging; Animals; Atropine; Autonomic Nervous System; Female; Heart Rate; Nitroprusside; Parasympathet

1991
The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts.
    The Journal of pharmacology and experimental therapeutics, 1991, Jul-01, Volume: 258, Issue:1

    Topics: Aging; Animals; Drug Interactions; Electrophysiology; Heart Conduction System; Injections, Intraperi

1991
Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam.
    The Journal of rheumatology. Supplement, 1990, Volume: 20

    Topics: Adult; Aged; Aging; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diazepam; Drug

1990
Peculiarities of neural regulation of the thyroid, adrenocortical and testicular functions in old age.
    Mechanisms of ageing and development, 1990, Volume: 51, Issue:1

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aging; Animals; Atropine; Dibenzylchlorethamine; Ketost

1990
Effect of aging on the response of guinea pig trachea to isoprenaline.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:3

    Topics: Aging; Animals; Corticosterone; Dihydroalprenolol; Guinea Pigs; In Vitro Techniques; Isoproterenol;

1990
Brown adipose tissue thermogenic responses of rats induced by central stimulation: effect of age and cold acclimation.
    The Journal of physiology, 1990, Volume: 426

    Topics: Acclimatization; Adipose Tissue, Brown; Aging; Animals; Blood Pressure; Body Temperature Regulation;

1990
Enhanced sympathetic mediation of chronotropic baroreflexes in old Sprague-Dawley rats.
    Mechanisms of ageing and development, 1990, Apr-09, Volume: 53, Issue:2

    Topics: Aging; Animals; Atropine Derivatives; Blood Pressure; Efferent Pathways; Heart Rate; Male; Nitroprus

1990
Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1

    Topics: Aging; Animals; Antipyrine; Atenolol; Male; Metabolic Clearance Rate; Metoprolol; Orosomucoid; Propr

1990
The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats.
    British journal of pharmacology, 1990, Volume: 100, Issue:3

    Topics: Aging; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; M

1990
Ontogeny of isoproterenol-stimulated renin secretion from sheep renal cortical slices.
    The American journal of physiology, 1989, Volume: 256, Issue:6 Pt 2

    Topics: Aging; Animals; Animals, Newborn; Aspirin; Edetic Acid; Fetus; Gestational Age; Isoproterenol; Kidne

1989
Resting heart rates in an ambulatory elderly population: an evaluation of age, sex, symptoms, and medication.
    Gerontology, 1989, Volume: 35, Issue:4

    Topics: Aged; Aging; Blood Pressure; Digoxin; Female; Heart Rate; Humans; Male; Nitroglycerin; Propranolol;

1989
Dissociation between c-fos gene expression and DNA synthesis in rat parotid glands.
    Archives of oral biology, 1989, Volume: 34, Issue:7

    Topics: Aging; Animals; Blotting, Northern; Carbachol; DNA; Epinephrine; Gene Expression; Isoproterenol; Mal

1989
Lipolytic response of bovine adipose tissue to alpha and beta adrenergic agents 30 days pre- and 120 days postpartum.
    General pharmacology, 1989, Volume: 20, Issue:3

    Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; A

1989
Specific age-dependence in capacity-limited uptake of propranolol by isolated rat lung.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:6

    Topics: Aging; Animals; In Vitro Techniques; Lung; Male; Propranolol; Rats; Rats, Inbred Strains

1989
Interaction of noradrenergic and cholinergic systems in regulation of ocular dominance plasticity.
    Neuroscience research, 1989, Volume: 6, Issue:6

    Topics: Aging; Animals; Bethanechol; Bethanechol Compounds; Cats; Cholinergic Fibers; Dose-Response Relation

1989
Ontogeny of neuronally released norepinephrine on renin secretion in sheep.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 2

    Topics: Aging; Animals; Animals, Newborn; Fetus; In Vitro Techniques; Kidney Cortex; Kinetics; Neurons; Nore

1989
Stereoselective binding of propranolol in the elderly.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:4

    Topics: Adult; Aged; Aging; Blood Proteins; Dialysis; Humans; Male; Orosomucoid; Propranolol; Protein Bindin

1989
Effects of aging on agonist-activated 86Rb efflux in arteries of Fischer 344 rats.
    The American journal of physiology, 1989, Volume: 257, Issue:2 Pt 2

    Topics: Aging; Animals; Aorta, Thoracic; Arteries; Male; Mesenteric Arteries; Muscle Development; Muscle, Sm

1989
The effects of ageing on neuronal uptake of noradrenaline in the rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:2

    Topics: Aging; Animals; Cocaine; Corticosterone; Decerebrate State; Heart; Heart Rate; Hemodynamics; Isoprot

1989
Emergence of beta adrenergic-responsive hepatic glycogenolysis in male rats during post-maturational aging.
    Biochemical and biophysical research communications, 1987, Sep-15, Volume: 147, Issue:2

    Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Epinephrine; Glucagon; Glucose; Gly

1987
Noradrenergic modulation of olfactory bulb excitability in the postnatal rat.
    Brain research, 1988, Jul-01, Volume: 470, Issue:1

    Topics: Action Potentials; Aging; Animals; Electric Stimulation; Female; Isoproterenol; Male; Norepinephrine

1988
In vivo demonstration of maturational changes of the chronotropic response to alpha-adrenergic stimulation.
    Pediatric research, 1988, Volume: 24, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Dogs; Heart Rate; Parasympathetic Nervous System;

1988
[Influence of hypertension and age on the sympathetic and parasympathetic components of cardiac baroreflex in the conscious rat].
    Archives des maladies du coeur et des vaisseaux, 1988, Volume: 81 Spec No

    Topics: Aging; Animals; Atropine; Heart; Hypertension; Male; Parasympathetic Nervous System; Phenylephrine;

1988
[Transport of univalent cations across the erythrocyte membrane of hypertensive rats of various ages].
    Tsitologiia, 1988, Volume: 30, Issue:11

    Topics: Aging; Animals; Biological Transport; Calcium Channels; Cations, Monovalent; Culture Media; Erythroc

1988
Isoproterenol-sensitive adenylate cyclase in glomeruli isolated from young and adult rat renal cortex.
    General pharmacology, 1985, Volume: 16, Issue:3

    Topics: Adenylyl Cyclases; Aging; Alkaline Phosphatase; Animals; Enzyme Activation; Fluorides; gamma-Glutamy

1985
Effect of age on the hepatic clearance of propranolol in rats.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:7

    Topics: Administration, Oral; Aging; Animals; Blood Proteins; Injections, Intravenous; Kidney; Kinetics; Liv

1985
Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol.
    Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Bromazepam; Cimetidine; Contraceptive

1987
Influence of beta-adrenoceptor-mediated relaxation on alpha-adrenoceptor-mediated contraction of rat pulmonary artery to adrenaline or noradrenaline.
    The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:4

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Male; Norepineph

1987
Effect of beta-adrenergic receptor blockade on responses to acute hypoxemia in lambs.
    Pediatric research, 1988, Volume: 23, Issue:2

    Topics: Acute Disease; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Cardiac Output; Heart

1988
Age-dependent pulmonary first-pass elimination of propranolol in rats.
    The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:2

    Topics: Aging; Animals; Half-Life; Injections, Intravenous; Lung; Male; Propranolol; Rats; Rats, Inbred Stra

1988
Age-dependent beta-adrenergic response of neuronal discharge in the raphe dorsalis: evidence of a transient regulation.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1988, Volume: 6, Issue:3

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Electrophysiology; Neurons; Propranol

1988
Lymphocyte protein kinase activity in cells from young and elderly men and women.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 180, Issue:3

    Topics: Adult; Aged; Aging; Colforsin; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; Humans; Isoprotere

1985
Developmental alteration in adrenergic regulation of hepatic glycogen phosphorylase.
    Japanese journal of pharmacology, 1986, Volume: 40, Issue:1

    Topics: Aging; Animals; Cyclic AMP; Epinephrine; In Vitro Techniques; Isoproterenol; Liver; Liver Glycogen;

1986
Regulation of beta adrenergic receptors on rat mononuclear leukocytes by stress: receptor redistribution and down-regulation are altered with aging.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1

    Topics: Aging; Animals; Cyclic AMP; Dihydroalprenolol; Isoproterenol; Male; Monocytes; Propanolamines; Propr

1987
[Age dependent quantitative evaluations of sensitivity changes in beta adrenergic receptors to isoprenaline and propranolol].
    Kardiologia polska, 1986, Volume: 29, Issue:7

    Topics: Adult; Aged; Aging; Humans; Isoproterenol; Male; Middle Aged; Propranolol; Receptors, Adrenergic, be

1986
Age-related change in alpha-adrenergic responsiveness of the urinary bladder of the rat is regionally specific.
    Neuropharmacology, 1986, Volume: 25, Issue:12

    Topics: Aging; Animals; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potas

1986
Desipramine and noradrenergic neurotransmission in aging: failure to respond in aged laboratory animals.
    Neuropharmacology, 1987, Volume: 26, Issue:6

    Topics: Action Potentials; Aging; Animals; Desipramine; Electric Stimulation; Hydroxydopamines; Male; Norepi

1987
The influence of age on human pancreatic growth hormone releasing hormone stimulated growth hormone secretion.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1988, Volume: 20, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Hum

1988
Early postnatal treatment with propranolol affects development of brain amines and behavior.
    Psychopharmacology, 1988, Volume: 96, Issue:3

    Topics: Acoustic Stimulation; Aging; Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Biogenic

1988
Regulation of lipolysis during the neonatal period. Importance of thyrotropin.
    The Journal of clinical investigation, 1988, Volume: 82, Issue:5

    Topics: Adenosine Deaminase; Adipose Tissue; Adult; Aging; Child; Child, Preschool; Epinephrine; Gestational

1988
Electrophysiologic effects of intravenous propranolol in the intact immature mammalian heart.
    Developmental pharmacology and therapeutics, 1988, Volume: 11, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Bundle of His; Dogs; Electric Stimulation; Electrophysiology; Fema

1988
Developmental changes in the effects of nadolol on adult and neonatal canine Purkinje fibers.
    Developmental pharmacology and therapeutics, 1988, Volume: 11, Issue:3

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Heart Conduction System; In Vitro Techniq

1988
Transplantation of norepinephrine neurons into aged rats improves performance of a learned task.
    Brain research, 1988, May-10, Volume: 448, Issue:1

    Topics: Aging; Animals; Avoidance Learning; Brain; Fetus; Male; Memory; Microscopy, Fluorescence; Neurons; N

1988
Age-dependent changes in the response of isolated beagle coronary arteries to transmural electrical stimulation and catecholamines.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1

    Topics: Acetylcholine; Aging; Animals; Catecholamines; Coronary Circulation; Coronary Vessels; Dinoprost; Do

1986
Age-dependence in capacity-limited uptake kinetics of propranolol by isolated rat hepatocytes.
    Biochemical pharmacology, 1986, Aug-15, Volume: 35, Issue:16

    Topics: Aging; Animals; Cell Survival; Culture Media; Kinetics; Liver; Male; Propranolol; Rats; Rats, Inbred

1986
Age dependence of adenylate cyclase in guinea pig ureter homogenate.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: Adenylyl Cyclases; Aging; Alprostadil; Animals; Colforsin; Enzyme Activation; Ethanol; Guanosine Tri

1986
Developmental changes in the effects of beta-adrenergic blocking concentrations of propranolol on canine Purkinje fibers.
    Developmental pharmacology and therapeutics, 1986, Volume: 9, Issue:6

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Heart Conduction System; Isoproterenol; P

1986
The effect of ageing and disease on tear constituents.
    Transactions of the ophthalmological societies of the United Kingdom, 1985, Volume: 104 ( Pt 4)

    Topics: Adult; Aged; Aging; Blepharitis; Ceruloplasmin; Eyelid Diseases; Humans; Immunoglobulin A; Immunoglo

1985
Effect of chronic treatment of propranolol on lipid metabolism in spontaneously hypertensive rats (SHR).
    Japanese journal of pharmacology, 1985, Volume: 37, Issue:4

    Topics: Aging; Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Fatty Acids, Nonesterified;

1985
Age-dependent propranolol clearance in perfused rat liver.
    Biochemical pharmacology, 1986, Apr-01, Volume: 35, Issue:7

    Topics: Aging; Animals; Liver; Male; Metabolic Clearance Rate; Perfusion; Propranolol; Rats; Rats, Inbred St

1986
Reactivity of small vessels from mature to senescent female rabbits.
    Blood vessels, 1985, Volume: 22, Issue:4

    Topics: Aging; Angiotensin II; Animals; Ear; Female; Femoral Artery; Histamine; Muscle Contraction; Muscle,

1985
Electrophysiological analysis of the nature of adrenoceptors in the rat basilar artery during development.
    British journal of pharmacology, 1985, Volume: 86, Issue:1

    Topics: Action Potentials; Aging; Animals; Basilar Artery; Female; Iontophoresis; Isoproterenol; Male; Membr

1985
Metabolic responses to cold and catecholamines as a function of age in swine (Sus domesticus).
    Comparative biochemistry and physiology. A, Comparative physiology, 1973, May-01, Volume: 45, Issue:1

    Topics: Adrenal Glands; Aging; Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Body Temperature Re

1973
Regulation of the adenosine cyclic 3',5'-monophosphate content of rat cerebral cortex: ontogenetic development of the responsiveness to catecholamines and adenosine.
    Molecular pharmacology, 1973, Volume: 9, Issue:6

    Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Adrenergic alp

1973
Heart rate after combined vagal and sympathetic blockade with atropine and different beta-receptor blocking agents.
    International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 8, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aging; Atropine; Dose-Response Relationship, Drug; Electrocardio

1973
Age differences in the baroreceptor response of rats.
    Journal of gerontology, 1974, Volume: 29, Issue:5

    Topics: Adrenergic beta-Antagonists; Aging; Animals; Atropine; Blood Pressure; Cardiac Output; Heart Rate; I

1974
The "natural" history of severe angina pectoris with intensive medical therapy alone: a five year prospective study of 133 patients.
    Chest, 1974, Volume: 65, Issue:1

    Topics: Adult; Aged; Aging; Angina Pectoris; Atrial Fibrillation; Cardiomegaly; Cerebrovascular Disorders; D

1974
Neuroendocrine control of the cyclic AMP system of brain and pineal gland.
    Advances in cyclic nucleotide research, 1972, Volume: 1

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Circadian Rhythm; Cyclic AMP; Kinetics; Light; Norepinephr

1972
Increased sensitivity of sinoatrial pace-maker to acetylcholine and to catecholamines at the onset of autonomic neuroeffector transmission in chick embryo heart.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 191, Issue:3

    Topics: Acetylcholine; Aging; Animals; Atropine; Autonomic Fibers, Postganglionic; Chick Embryo; Electric St

1974
[Prevention and general therapy of coronary insufficiency].
    Giornale di gerontologia, 1971, Volume: 19, Issue:1

    Topics: Aged; Aging; Angina Pectoris; Anticoagulants; Coronary Disease; Ethanolamines; Humans; Middle Aged;

1971
Cardiac performance in the unanesthetized senescent male rat.
    Journal of gerontology, 1973, Volume: 28, Issue:3

    Topics: Aging; Animals; Arteries; Blood Pressure; Cardiac Output; Female; Heart; Heart Rate; Male; Propranol

1973
Renin-like activity in submaxillary gland in several strains of rats including the spontaneously hypertensive rat.
    Biochemical pharmacology, 1972, Aug-01, Volume: 21, Issue:15

    Topics: Aging; Animals; Blood Pressure; Female; Hypertension; Kidney; Male; Nephrectomy; Propranolol; Rats;

1972
Heart rate changes with age in chickens.
    Poultry science, 1972, Volume: 51, Issue:3

    Topics: Aging; Animals; Atropine; Chickens; Electrocardiography; Female; Heart Rate; Injections, Intravenous

1972
Properties of adenylate cyclase from senescent rat brain.
    Brain research, 1973, May-17, Volume: 54

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Caudate Nucleus; Cell-Free System; Cerebellum; Cerebral Co

1973
Heart rate and haemodynamics after autonomic blockade in infants and children.
    British heart journal, 1970, Volume: 32, Issue:6

    Topics: Adolescent; Aging; Atropine; Autonomic Nerve Block; Cardiac Catheterization; Child; Child, Preschool

1970
[Therapy of acute myocardial infarct with particular reference to arrhythmia and myocardial contractibility disorders].
    Giornale di gerontologia, 1971, Volume: 19, Issue:1

    Topics: Adult; Aged; Aging; Arrhythmias, Cardiac; Atropine; Cardiac Glycosides; Cortisone; Electric Counters

1971
The release of a bradykinin-like pulmonary vasodilator substance in foetal and new-born lambs.
    The Journal of physiology, 1968, Volume: 195, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Atropine; Bradykinin; Female; Fetus; Glass; Injections, Intra-Arte

1968