propranolol has been researched along with Aging in 262 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of aging on the hepatic metabolism of propranolol, i." | 9.08 | Influence of aging on the oxidative and conjugative metabolism of propranolol. ( Ebihara, A; Fujimura, A; Ohashi, K; Shiga, T; Tateishi, T, 1995) |
| "The influence of aging on the pharmacokinetics and the tissue distribution of (R)- and of (S)-propranolol was studied in 3-, 12-, and 24-month-old rats." | 7.68 | The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat. ( Belpaire, FM; Bogaert, MG; de Smet, F; Moerman, E; Vermeulen, AM, 1992) |
| "The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0." | 7.68 | The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991) |
| " Salivary flow rates, induced by pilocarpine, were not decreased by the chronic administration of propranolol." | 5.29 | The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993) |
| " administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age." | 5.28 | Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990) |
| "The effects of aging on alpha(1)-adrenoceptor (alpha(1)-AR)-mediated contractile response in endothelium-removed aortic preparations isolated from 5- to 40-week-old (5-, 6-, 8-, 10-, 20-, 40-weeks) mice were studied in the presence of propranolol." | 3.73 | Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation. ( Funabiki, M; Koike, K; Michikawa, H; Tanaka, Y, 2006) |
| "We analysed the influence of aging on the acute effect of clenbuterol, a beta(2)-adrenoceptor agonist, on the vasoconstrictor response induced by electrical field stimulation in mesenteric arteries from young and old spontaneously hypertensive rats (SHRs)." | 3.72 | Different effects of acute clenbuterol on vasomotor response in mesenteric arteries from young and old spontaneously hypertensive rats. ( Balfagón, G; Ferrer, M; Salaices, M; Sánchez, M, 2003) |
| "Blood stroke volume in rats aging 21 and 56 days decreased during beta-adrenoceptor blockade with propranolol, but increased again by the 15th minute after treatment." | 3.72 | Age-related differences in the response of blood stroke volume to stimulation of the sympathetic ganglion in rats with beta-adrenoceptor blockade. ( Anikina, TA; Bilalova, GA; Sitdikov, FG, 2004) |
| "We previously reported that insulin-induced hypoglycemia (IIH) induces a large increase in plasma ACTH and corticosterone levels in the developing rat during the stress hyporesponsive period and that this effect is mediated, at least partially, by arginine vasopressin (AVP), but not corticotropin-releasing factor." | 3.68 | Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. ( Grino, M; Oliver, C, 1992) |
| "The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0." | 3.68 | The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991) |
| " In 20 subjects with uncomplicated essential hypertension, 10 of whom were on propranolol treatment, several blood samples were drawn simultaneously from the renal artery and vein after angiographic studies." | 3.66 | Noradrenaline secretion by the human kidney. ( Birkenhäger, WH; de Leeuw, PW; Falke, HE; Punt, R, 1978) |
| " To determine whether age-related changes in alpha 1-acid glycoprotein influence drug binding in mother and newborn infant and also the effects of sex, pregnancy, and oral contraceptives on drug binding, the binding of lidocaine, diazepam, propranolol, d-tubocurarine, and metocurine was determined by equilibrium dialysis in 17 men, 16 nonpregnant women, 16 nonpregnant women on oral contraceptives, and 15 mothers and their newborn infants at delivery." | 3.66 | Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant. ( Wood, AJ; Wood, M, 1981) |
| " Bioavailability of tetrahydrobiopterin (BH4), an essential cofactor for catecholamine synthesis, is reduced with aging." | 2.78 | Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms. ( Alexander, LM; Kenney, WL; Stanhewicz, AE, 2013) |
| " No statistical differences were detected in the experimental propranolol pharmacokinetic parameters (maximal concentration, time of maximal concentration, terminal half-life, area under the curve, and protein binding) or derived pharmacokinetic parameters (intrinsic clearance, bioavailability, clearance, and volume of distribution)." | 2.68 | The lack of effect of aerobic exercise training on propranolol pharmacokinetics in young and elderly adults. ( Cediel, M; Derendorf, H; Garzarella, L; Graves, JE; Guillen, GJ; Krumerman, J; Panton, LB; Pollock, ML; Vivas, C; Williams, L, 1995) |
| " Drug interaction studies with fluvastatin and cholestyramine (CME) demonstrated a lower rate and extent of fluvastatin bioavailability; no impact on efficacy was demonstrated when CME was given 4 h before fluvastatin dosing in clinical trials." | 2.67 | Pharmacokinetics of fluvastatin and specific drug interactions. ( Hwang, DS; Jokubaitis, LA; Robinson, WT; Smith, HT; Troendle, AJ, 1993) |
| "Propranolol prevented the increase in QT/QS2 ratio induced by active standing." | 2.66 | Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes. ( Acanfora, D; Canonico, V; Cicatiello, AM; Cuomo, S; De Caprio, L; Gallucci, F; Papa, M; Rengo, F; Vigorito, C, 1989) |
| "1 Pharmacokinetic investigations were carried out in a group of 32 ambulant normal male volunteers in order to determine the effect of age and smoking on steady-state plasma levels of pindolol and propranolol." | 2.65 | Effects of age and smoking on the pharmacokinetics of pindolol and propranolol. ( Beveridge, T; Fitscha, P; Hitzenberger, G; Nüesch, E; Pacha, W, 1982) |
| "This tremor is normally recordable at a stable frequency of 8-10 Hz, though this can be influenced by age, the amplitude can vary substantially." | 2.39 | [Most frequent causes for hand tremor in clinical practice]. ( Málly, J, 1995) |
| "When propranolol was administered at either 5-, 60-, or 120-min post-training, there was an inhibition of conditioned responses, these data support the hypothesis that NE is important for consolidation of learning." | 1.35 | Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age. ( Avilas, M; Bickford, PC; Cartford, MC; Catlow, BJ; George, A; Paredes, DA; Samec, A; Schlunck, A; Small, B, 2009) |
| " Local BH(4) supplementation augments reflex and tyramine-induced VC in aged skin, suggesting that reduced BH(4) bioavailability may contribute to attenuated VC during whole-body cooling." | 1.35 | Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans. ( Holowatz, LA; Kenney, WL; Lang, JA, 2009) |
| " Salivary flow rates, induced by pilocarpine, were not decreased by the chronic administration of propranolol." | 1.29 | The effect of propranolol on salivary gland function and dental caries development in young and aged rats. ( Bowen, WH; O'Connell, AC; Pearson, SK; Van Wuyckhuyse, BC, 1993) |
| "Propranolol treatment (10(-5) M) increased Fmax (2-fold) only for newborn lamb MCAs." | 1.29 | Nitric oxide and beta-adrenergic mechanisms modify contractile responses to norepinephrine in ovine fetal and newborn cerebral arteries. ( Moliken, W; Russo, P; Wagerle, LC, 1995) |
| "We studied the effects of chronic administration of beta-adrenoceptor antagonists with and without intrinsic sympathomimetic activity (ISA): carteolol (with ISA) and propranolol (without ISA), respectively, on the heart of spontaneously hypertensive rat (SHR) and Wistar Kyoto rat (WKY)." | 1.28 | Effects of chronic administration of carteolol on beta-adrenoceptors in spontaneously hypertensive rat heart. ( Ebii, K; Fujiwara, M; Fukunaga, R; Kimura, Y; Nakayama, S; Saitoh, Y; Taniguchi, T, 1991) |
| " We therefore conclude: (i) that the diminution of the cardiac response to the sympathetic and vagal stimulations during ageing may be partly explained by a decrease in the corresponding receptor density; (ii) these changes are reversible and the density of these two groups of receptors can return to adult control values by chronic administration of the appropriate antagonist." | 1.28 | Alterations in beta adrenergic and muscarinic receptors in aged rat heart. Effects of chronic administration of propranolol and atropine. ( Callen-el Amrani, F; Chevalier, B; Mansier, P; Swynghedauw, B; Teiger, E, 1991) |
| " Pharmacokinetic variable values in elderly subjects did not differ in a clinically significant manner from those in younger subjects." | 1.28 | Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam. ( Karim, A; Nicholson, PA; Smith, M, 1990) |
| " administration of the beta blockers, no significant increase in area under the plasma drug concentration-time curve was observed for propranolol and metoprolol as a function of age, but for atenolol, a significant increase in area under the plasma drug concentration-time curve was seen in the 24-month-old rats, due to a decrease in renal function, as bioavailability of atenolol did not change in function of age." | 1.28 | Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat. ( Belpaire, FM; Bogaert, MG; Chauvelot-Moachon, L; de Smet, F; Rosseel, MT; Vermeulen, AM; Vynckier, LJ, 1990) |
| " Cumulative dose-response curves of plasma cyclic AMP concentration obtained in another group of rats after successive subcutaneous injections of isoproterenol showed that the ED50 value of this drug was higher in SHR than in WKY and increased in a parallel manner in the two strains between 7 and 18 weeks of age (respectively from 0." | 1.27 | Age-related changes of in vivo beta-adrenergic responsiveness in normotensive and spontaneously hypertensive rats. ( Bucher, B; Heitz, C; Stoclet, JC, 1984) |
| "0 mg/kg intravenously) was administered after the highest phenylephrine infusion dosage to assure complete beta-blockade." | 1.27 | In vivo demonstration of maturational changes of the chronotropic response to alpha-adrenergic stimulation. ( Gelband, H; McCormack, J; Pickoff, AS; Stolfi, A; Villafañe, J; Xu, H, 1988) |
| " Pharmacokinetic analysis of the plasma propranolol data obtained after i." | 1.27 | Effect of age on the hepatic clearance of propranolol in rats. ( Araki, K; Deguchi, N; Iwamoto, K; Sugiyama, H; Watanabe, J, 1985) |
| "82 ml/min/kg) and prolonged elimination half-life (29 vs." | 1.27 | Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol. ( Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Ochs, HR; Shader, RI, 1987) |
| " Although there was a statistically significant difference in certain pharmacokinetic parameters (maximum plasma concentration, area under the curve, elimination constant and elimination half-life) between elderly patients (more that 60 years) and young persons (20-30 years) no significant differences were found as far as smoking and nonsmoking is concerned." | 1.26 | Influence of smoking and age on pharmacokinetics of beta-receptor blockers. ( Beveridge, T; Fitscha, P; Hitzenberger, G; Nüesch, E; Pacha, W, 1982) |
| " No age differences were seen in the time course of amylase release following (-)-isoproterenol stimulation or in the (-)-isoproterenol dose-response curve." | 1.26 | Beta-adrenergic regulation of rat parotid gland exocrine protein secretion during aging. ( Baum, BJ; Ito, H; Roth, GS, 1981) |
| "Propranolol did not cause this pressor effect in prehypertensive (seven week old) SHRs." | 1.26 | Beta-adrenergic receptor blocking drugs in spontaneous hypertension. ( Levy, JV, 1976) |
| " The terminal half-life of propranolol was similar in the two groups after oral propranolol but significantly shorter in the young after intravenous dosing (P less than 0." | 1.26 | The effect of ageing on the hepatic clearance of propranolol. ( Castleden, CM; George, CF, 1979) |
| " Observed on four drug-induced behavior categories, it was found that both clonidine and propranolol attenuated the toxic effects of relatively low dose levels of digitoxin, while at higher digitoxin dose levels only propranolol was able to reduce significantly the ED50 and the LD50." | 1.26 | Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice. ( Felleman, VH; Palfai, T, 1982) |
| "7 Cimetidine was without effect on histamine sensitivity in young guinea-pigs after propranolol treatment but significantly reduced airway sensitivity to histamine in old guinea-pigs." | 1.26 | Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development. ( Brink, C; Douglas, JS; Duncan, PG, 1982) |
| "The biphasic nature of the lipolytic dose-response curve of epinephrine in fat cells from "young" rats (40-45 days) was confirmed." | 1.25 | Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats. ( Allen, DO; Miller, EA, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 148 (56.49) | 18.7374 |
| 1990's | 73 (27.86) | 18.2507 |
| 2000's | 24 (9.16) | 29.6817 |
| 2010's | 16 (6.11) | 24.3611 |
| 2020's | 1 (0.38) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, AK | 1 |
| Park, HH | 1 |
| Saw, NL | 1 |
| Singhal, K | 1 |
| Ogawa, G | 1 |
| Leib, RD | 1 |
| Shamloo, M | 1 |
| Bilalova, GA | 3 |
| Sitdikov, FG | 3 |
| Dikopol'skaya, NB | 1 |
| Shaikhelislamova, MV | 1 |
| Zefirov, TL | 1 |
| Chatzidou, S | 1 |
| Georgiopoulos, G | 1 |
| Kontogiannis, C | 1 |
| Stanhewicz, AE | 1 |
| Alexander, LM | 1 |
| Kenney, WL | 2 |
| Muller, MD | 2 |
| Gao, Z | 2 |
| Patel, HM | 1 |
| Heffernan, MJ | 1 |
| Leuenberger, UA | 2 |
| Sinoway, LI | 2 |
| Bratt, EL | 1 |
| Östman-Smith, I | 1 |
| Ross, AJ | 1 |
| Pollock, JP | 1 |
| Blagosklonny, MV | 1 |
| Sun, X | 1 |
| Su, Y | 1 |
| He, Y | 1 |
| Zhang, J | 1 |
| Liu, W | 1 |
| Zhang, H | 1 |
| Hou, Z | 1 |
| Liu, J | 1 |
| Li, J | 1 |
| Skelly, MJ | 1 |
| Chappell, AE | 1 |
| Carter, E | 1 |
| Weiner, JL | 1 |
| Briant, LJ | 1 |
| Burchell, AE | 1 |
| Ratcliffe, LE | 1 |
| Charkoudian, N | 1 |
| Nightingale, AK | 1 |
| Paton, JF | 1 |
| Joyner, MJ | 1 |
| Hart, EC | 1 |
| Fernandois, D | 1 |
| Cruz, G | 1 |
| Na, EK | 1 |
| Lara, HE | 1 |
| Paredes, AH | 1 |
| Paredes, DA | 1 |
| Cartford, MC | 1 |
| Catlow, BJ | 1 |
| Samec, A | 1 |
| Avilas, M | 1 |
| George, A | 1 |
| Schlunck, A | 1 |
| Small, B | 1 |
| Bickford, PC | 1 |
| Wray, DW | 1 |
| Nishiyama, SK | 1 |
| Richardson, RS | 1 |
| Mongue-Din, H | 1 |
| Salmon, A | 1 |
| Fiszman, MY | 1 |
| Fromes, Y | 1 |
| Lang, JA | 1 |
| Holowatz, LA | 1 |
| Koyanagi, Y | 1 |
| Yamamoto, K | 1 |
| Oi, Y | 1 |
| Koshikawa, N | 1 |
| Kobayashi, M | 1 |
| Fedorets, VN | 1 |
| Snyder, KA | 1 |
| Shamimi-Noori, S | 1 |
| Wilson, TE | 1 |
| Monahan, KD | 1 |
| Ghosh, PM | 1 |
| Shu, ZJ | 1 |
| Zhu, B | 1 |
| Lu, Z | 1 |
| Ikeno, Y | 1 |
| Barnes, JL | 1 |
| Yeh, CK | 1 |
| Zhang, BX | 1 |
| Katz, MS | 2 |
| Kamat, A | 1 |
| Dobarro, M | 1 |
| Orejana, L | 1 |
| Aguirre, N | 1 |
| Ramírez, MJ | 1 |
| Ferrer, M | 2 |
| Salaices, M | 2 |
| Sánchez, M | 1 |
| Balfagón, G | 3 |
| Tamaya-Mori, N | 1 |
| Uemura, K | 1 |
| Tanaka, S | 2 |
| Iguchi, A | 1 |
| Braga, MF | 1 |
| Aroniadou-Anderjaska, V | 1 |
| Manion, ST | 1 |
| Hough, CJ | 1 |
| Li, H | 1 |
| Anikina, TA | 2 |
| Plećas-Solarović, B | 1 |
| Lalić, L | 1 |
| Leposavić, G | 1 |
| Ruiz-Feria, CA | 1 |
| Yang, Y | 1 |
| Nishimura, H | 1 |
| Cruickshank, JM | 1 |
| Tanaka, Y | 1 |
| Funabiki, M | 1 |
| Michikawa, H | 1 |
| Koike, K | 2 |
| Ohe, T | 1 |
| Imamura, K | 2 |
| Kasamatsu, T | 2 |
| Švíglerová, J | 1 |
| Kuncová, J | 1 |
| Nalos, L | 1 |
| Slavíková, J | 1 |
| Stengl, M | 1 |
| Bucher, B | 1 |
| Heitz, C | 1 |
| Stoclet, JC | 1 |
| Gatto, C | 1 |
| Johnson, MG | 1 |
| Seybold, V | 1 |
| Kulik, TJ | 1 |
| Lock, JE | 1 |
| Johnson, DE | 1 |
| Bianchetti, G | 1 |
| Brancaccio, D | 1 |
| Forette, F | 1 |
| Henry, JF | 1 |
| Hervy, MP | 1 |
| Ganansia, J | 1 |
| Gomeni, R | 1 |
| Kilborn, JR | 1 |
| Morselli, PL | 1 |
| Hitzenberger, G | 2 |
| Fitscha, P | 2 |
| Beveridge, T | 2 |
| Nüesch, E | 2 |
| Pacha, W | 2 |
| Minaker, KL | 1 |
| Rowe, JW | 2 |
| McKenna, WJ | 1 |
| Borggrefe, M | 1 |
| England, D | 1 |
| Deanfield, J | 1 |
| Oakley, CM | 1 |
| Goodwin, JF | 1 |
| Twomey, JJ | 1 |
| Kouttab, NM | 1 |
| Stiles, GL | 1 |
| Caron, MG | 1 |
| Lefkowitz, RJ | 1 |
| Ito, H | 1 |
| Baum, BJ | 2 |
| Roth, GS | 2 |
| Kim, SK | 1 |
| Calkins, DW | 1 |
| Weinhold, PA | 1 |
| Carlsöö, B | 1 |
| Danielsson, A | 1 |
| Henriksson, R | 1 |
| Yamazaki, N | 1 |
| Hosoki, R | 1 |
| Takayanagi, I | 2 |
| Abrass, IB | 1 |
| Scarpace, PJ | 1 |
| Troen, BR | 1 |
| Chen, FC | 1 |
| Yamamura, HI | 1 |
| Roeske, WR | 1 |
| Morgan, NG | 1 |
| Blackmore, PF | 1 |
| Exton, JH | 1 |
| Marin-Cao, D | 1 |
| Alvarez Chiva, V | 1 |
| Mato, JM | 1 |
| O'Donnell, SR | 2 |
| Wanstall, JC | 2 |
| Reaven, E | 1 |
| Wright, D | 2 |
| Mondon, CE | 3 |
| Solomon, R | 1 |
| Ho, H | 1 |
| Reaven, GM | 3 |
| Speiser, Z | 1 |
| Shved, A | 1 |
| Gitter, S | 1 |
| Narimiya, M | 1 |
| Azhar, S | 1 |
| Dolkas, CB | 1 |
| Sims, C | 1 |
| Wright, DW | 1 |
| Brink, C | 1 |
| Douglas, JS | 1 |
| Duncan, PG | 1 |
| Caza, PA | 1 |
| Babak, OIa | 1 |
| Ferguson, AV | 1 |
| Bauce, L | 1 |
| Veale, WL | 1 |
| Cooper, KE | 1 |
| Bendayan, R | 1 |
| Pieper, JA | 1 |
| Stewart, RB | 2 |
| Caranasos, GJ | 1 |
| Greenfield, MS | 1 |
| Rosenthal, M | 1 |
| Reaven, EP | 1 |
| Szabolcs, I | 2 |
| Szilágyi, G | 2 |
| Góth, M | 2 |
| Kovács, Z | 2 |
| Weber, M | 2 |
| Halász, T | 2 |
| Heath, M | 1 |
| Ingram, DL | 1 |
| Deguchi, T | 1 |
| Driscoll, DJ | 1 |
| Fukushige, J | 1 |
| Lewis, RM | 1 |
| Hartley, CJ | 1 |
| Entman, MJ | 1 |
| King, TS | 1 |
| Dougherty, WJ | 1 |
| Yorek, MA | 1 |
| Blair, JB | 3 |
| Ray, PD | 1 |
| Palfai, T | 1 |
| Felleman, VH | 1 |
| Brammer, M | 1 |
| Binkley, S | 1 |
| Mosher, K | 1 |
| Irsy, G | 1 |
| Lowenthal, DT | 1 |
| Affrime, MB | 1 |
| Yin, FC | 2 |
| Weisfeldt, ML | 3 |
| Milnor, WR | 1 |
| Park, MK | 1 |
| Wexler, BC | 1 |
| McMurtry, JP | 1 |
| de Champlain, J | 1 |
| Cousineau, D | 1 |
| Lapointe, L | 1 |
| Wood, M | 1 |
| Wood, AJ | 3 |
| Málly, J | 1 |
| Wagerle, LC | 1 |
| Moliken, W | 1 |
| Russo, P | 1 |
| Iushkova, AA | 1 |
| Dygalo, NN | 1 |
| Pacioretty, LM | 1 |
| Gilmour, RF | 1 |
| Conlon, D | 2 |
| Johnston, A | 2 |
| O'Malley, K | 2 |
| Turner, P | 2 |
| Kilfeather, S | 2 |
| Kyriakides, ZS | 1 |
| Papaioannou, G | 1 |
| Paraskevaidis, IA | 1 |
| Kolettis, TM | 1 |
| Kremastinos, DT | 1 |
| Craft, N | 1 |
| Schwartz, JB | 3 |
| Tanaka, H | 2 |
| Manita, S | 1 |
| Matsuda, T | 1 |
| Adachi, M | 1 |
| Shigenobu, K | 1 |
| Vercruysse, I | 1 |
| Vermeulen, AM | 4 |
| Belpaire, FM | 4 |
| Massart, DL | 1 |
| Dupont, AG | 1 |
| Shen, C | 1 |
| Garcia, J | 2 |
| Capili, H | 1 |
| Sniezek, M | 1 |
| Wilson, DA | 2 |
| Pham, TC | 1 |
| Sullivan, RM | 1 |
| Fleg, JL | 1 |
| Schulman, S | 1 |
| O'Connor, F | 1 |
| Becker, LC | 1 |
| Gerstenblith, G | 2 |
| Clulow, JF | 1 |
| Renlund, DG | 1 |
| Lakatta, EG | 3 |
| van Veldhuizen, MJ | 1 |
| Feenstra, MG | 1 |
| Botterblom, MH | 1 |
| Boer, GJ | 1 |
| Arribas, S | 1 |
| Marín, J | 1 |
| Ponte, A | 1 |
| Coutinho, LL | 1 |
| Bergen, WG | 1 |
| Romsos, DR | 1 |
| Merkel, RA | 1 |
| Pucéat, M | 1 |
| Hilal-Dandan, R | 1 |
| Strulovici, B | 1 |
| Brunton, LL | 1 |
| Brown, JH | 1 |
| O'Connell, AC | 2 |
| Van Wuyckhuyse, BC | 1 |
| Pearson, SK | 1 |
| Bowen, WH | 2 |
| Banerjee, A | 1 |
| Brook, MM | 1 |
| Klautz, RJ | 1 |
| Teitel, DF | 2 |
| Smith, HT | 1 |
| Jokubaitis, LA | 1 |
| Troendle, AJ | 1 |
| Hwang, DS | 1 |
| Robinson, WT | 1 |
| Liu, QY | 1 |
| Karpinski, E | 1 |
| Pang, PK | 1 |
| Polio, J | 1 |
| Sieber, CC | 1 |
| Lerner, E | 1 |
| Groszmann, RJ | 1 |
| Kuga, K | 1 |
| Yamaguchi, I | 1 |
| Sugishita, Y | 1 |
| Kennedy, AT | 1 |
| Kitchen, I | 1 |
| Hill, RG | 1 |
| Haidet, GC | 1 |
| de Smet, F | 3 |
| Bogaert, MG | 3 |
| Knudsen, JH | 1 |
| Christensen, NJ | 1 |
| Bratholm, P | 1 |
| Panton, LB | 1 |
| Guillen, GJ | 1 |
| Williams, L | 1 |
| Graves, JE | 1 |
| Vivas, C | 1 |
| Cediel, M | 1 |
| Pollock, ML | 1 |
| Garzarella, L | 1 |
| Krumerman, J | 1 |
| Derendorf, H | 1 |
| Tateishi, T | 1 |
| Fujimura, A | 1 |
| Shiga, T | 1 |
| Ohashi, K | 1 |
| Ebihara, A | 1 |
| Harmouch, A | 1 |
| Guerrero, JM | 1 |
| Pozo, D | 1 |
| Rafii-el-Idrissi, M | 1 |
| Calvo, JR | 1 |
| Reiter, RJ | 1 |
| Osuna, C | 1 |
| Xie, LH | 1 |
| Takano, M | 1 |
| Noma, A | 1 |
| Basso, A | 1 |
| Piantanelli, L | 1 |
| Rossolini, G | 1 |
| Baylis, C | 1 |
| Engels, K | 1 |
| Beierwaltes, WH | 1 |
| Miller, EA | 1 |
| Allen, DO | 1 |
| Oida, E | 2 |
| Kannagi, T | 2 |
| Moritani, T | 2 |
| Yamori, Y | 2 |
| Nigmatullina, RR | 1 |
| Abzalov, RA | 1 |
| Minnibaev, ESh | 1 |
| Masuda, Y | 2 |
| Suzuki, M | 1 |
| Akagawa, Y | 1 |
| Takemura, T | 1 |
| Dash, R | 1 |
| Kadambi, V | 1 |
| Schmidt, AG | 1 |
| Tepe, NM | 1 |
| Biniakiewicz, D | 1 |
| Gerst, MJ | 1 |
| Canning, AM | 1 |
| Abraham, WT | 1 |
| Hoit, BD | 1 |
| Liggett, SB | 1 |
| Lorenz, JN | 1 |
| Dorn, GW | 1 |
| Kranias, EG | 1 |
| Tsakiris, S | 1 |
| Aikawa, K | 1 |
| Yokota, T | 1 |
| Okamura , H | 1 |
| Yamaguchi, O | 1 |
| Bell, C | 1 |
| Seals, DR | 2 |
| Monroe, MB | 1 |
| Day, DS | 1 |
| Shapiro, LF | 1 |
| Johnson, DG | 1 |
| Jones, PP | 1 |
| Piccirillo, G | 1 |
| Cacciafesta, M | 1 |
| Lionetti, M | 1 |
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| Di Giuseppe, V | 1 |
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| Matthay, MA | 1 |
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| Levy, JV | 1 |
| Saarela, S | 1 |
| Mattila, T | 1 |
| Hissa, R | 1 |
| Hohtola, E | 1 |
| Bühler, FR | 3 |
| Berkowitz, BA | 1 |
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| Singh, U | 1 |
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| Smith, PA | 1 |
| Owen, JJ | 1 |
| Smith, CR | 1 |
| James, ME | 2 |
| Foster, JL | 2 |
| Watson, RD | 1 |
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| Wilkinson, GR | 2 |
| Vestal, RE | 1 |
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| Corre, KA | 1 |
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| Wilson, JT | 1 |
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| Moss, SF | 1 |
| Nowlin, JB | 1 |
| Portzer, D | 1 |
| Angell, CS | 3 |
| Shock, NW | 3 |
| Roberts, J | 2 |
| Goldberg, PB | 1 |
| Caspari, PG | 1 |
| Gibson, K | 1 |
| Harris, P | 1 |
| Kaye, CM | 1 |
| Parsons, RL | 1 |
| Legault, L | 1 |
| van Nguyen, P | 1 |
| Holliwell, DL | 1 |
| Leenen, FH | 1 |
| Mader, SL | 1 |
| Colangelo, PM | 2 |
| Blouin, RA | 2 |
| Steinmetz, JE | 2 |
| McNamara, PJ | 2 |
| DeMaria, AN | 2 |
| Wedlund, PJ | 2 |
| Teräväinen, TL | 2 |
| Buñag, RD | 4 |
| Van Ermen, A | 1 |
| Van de Velde, E | 1 |
| Vanscheeuwijck, P | 2 |
| Fraeyman, N | 2 |
| Grino, M | 1 |
| Oliver, C | 1 |
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| Mrochek, AG | 1 |
| Gorbachev, VV | 1 |
| Tiabut, TD | 1 |
| Zhou, HH | 1 |
| Whelan, E | 1 |
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| Nies, AS | 1 |
| Moerman, E | 1 |
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| Schmidlin, O | 1 |
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| Eriksson, L | 1 |
| Vynckier, LJ | 1 |
| Rosseel, MT | 1 |
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| Mollace, V | 1 |
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| Staessen, J | 1 |
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| Page, WV | 1 |
| Sato, T | 2 |
| Klinkefus, JM | 2 |
| Marks, RG | 1 |
| Hale, WE | 1 |
| Moore, MT | 1 |
| May, FE | 1 |
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| Smith, DJ | 1 |
| McNamara, JP | 1 |
| Iwamoto, K | 5 |
| Watanabe, J | 5 |
| Yonekawa, H | 1 |
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| Greenblatt, DJ | 2 |
| O'Rourke, MF | 1 |
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| Smith, FG | 1 |
| Colangelo, P | 1 |
| Chandler, M | 1 |
| Blouin, R | 1 |
| McNamara, P | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Wavelet Transform and Pharmacodynamic Analysis of Atropine and Propranolol Induced Changes in Human Heart Rate Variability[NCT00251602] | Phase 1 | 24 participants (Actual) | Interventional | 2003-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for propranolol and Aging
| Article | Year |
|---|---|
Koschei the immortal and anti-aging drugs.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Caloric Restriction; Exercise; Folklore; G | 2014 |
Beta-adrenergic receptors: biochemical mechanisms of physiological regulation.
Topics: Adenylyl Cyclases; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; A | 1984 |
Sympathetic nervous system and aging in man.
Topics: Adolescent; Adrenal Medulla; Adult; Aged; Aging; Animals; Blood Pressure; Child; Circadian Rhythm; C | 1980 |
[Most frequent causes for hand tremor in clinical practice].
Topics: Aged; Aged, 80 and over; Aging; Female; Hand; Humans; Hypokinesia; Male; Parkinson Disease; Posture; | 1995 |
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Fem | 1976 |
The application of clearance concepts to propranolol disposition in man.
Topics: Aging; Half-Life; Humans; Liver; Liver Diseases; Models, Biological; Propranolol; Smoking; Time Fact | 1979 |
Aging and the extrapyramidal system.
Topics: Aged; Aging; Basal Ganglia Diseases; Chlorpromazine; Chorea; Dopamine; Frontal Lobe; Gait; Haloperid | 1976 |
Plasma and tissue protein binding of drugs in pharmacokinetics.
Topics: Adrenal Cortex Hormones; Age Factors; Aging; Albumins; Animals; Anti-Bacterial Agents; Antibodies; A | 1976 |
Disposition of cardiovascular drugs in the elderly.
Topics: Aged; Aging; Cardiovascular Agents; Humans; Propranolol | 1989 |
Effects of arterial dilator agents on central aortic systolic pressure and on left ventricular hydraulic load.
Topics: Adult; Aging; Aorta; Blood Pressure; Blood Pressure Determination; Brachial Artery; Hemodynamics; Hu | 1989 |
16 trials available for propranolol and Aging
| Article | Year |
|---|---|
Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.
Topics: Aged; Aging; Arterial Pressure; Biopterins; Cross-Over Studies; Double-Blind Method; Female; Humans; | 2013 |
β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aging; Coronary Ves | 2014 |
Age- and limb-related differences in the vasoconstrictor response to limb dependency are not mediated by a sympathetic mechanism in humans.
Topics: Adrenergic Antagonists; Adult; Aged; Aging; Arm; Blood Pressure; Brachial Artery; Female; Heart Rate | 2012 |
Pharmacokinetics of SL 75212 and propranolol in old age, uraemia and in healthy young adults [proceedings].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Betaxolol; Female; Humans; Male; Propanolamines; Pr | 1980 |
Beta-blocker prophylaxis after myocardial infarction.
Topics: Aging; Clinical Trials as Topic; Double-Blind Method; Humans; Myocardial Infarction; Placebos; Propa | 1981 |
Effects of age and smoking on the pharmacokinetics of pindolol and propranolol.
Topics: Adult; Aged; Aging; Female; Humans; Kinetics; Male; Middle Aged; Pindolol; Propranolol; Smoking; Tim | 1982 |
Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans.
Topics: Adult; Aging; Atrioventricular Node; Atropine; Autonomic Nerve Block; Cardiac Pacing, Artificial; El | 1995 |
Pharmacokinetics of fluvastatin and specific drug interactions.
Topics: Adolescent; Adult; Aged; Aging; Biological Availability; Cholestyramine Resin; Diet; Digoxin; Dose-R | 1993 |
The lack of effect of aerobic exercise training on propranolol pharmacokinetics in young and elderly adults.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Chromatogr | 1995 |
Influence of aging on the oxidative and conjugative metabolism of propranolol.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Female; Half- | 1995 |
Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Adult; Aged; Aging; Body Mass Inde | 2001 |
Hemodynamic and plasma atrial natriuretic factor responses to cardiac volume loading in young versus older normotensive humans.
Topics: Adult; Aging; Atrial Natriuretic Factor; Cardiac Output; Central Venous Pressure; Double-Blind Metho | 1992 |
Double-blind comparison of ketanserin and propranolol in hypertensive patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Body Weight; Chromatography, High | 1988 |
Reduced susceptibility to syncope during postural tilt in old age. Is beta-blockade protective?
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Disease Susceptibility; Forearm; | 1989 |
Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Electrocardiography; Female; Heart; Humans; Male; | 1989 |
Improvement of learning in the aged by modification of autonomic nervous system activity.
Topics: Aged; Aging; Clinical Trials as Topic; Humans; Male; Middle Aged; Placebos; Propranolol; Sympathetic | 1970 |
236 other studies available for propranolol and Aging
| Article | Year |
|---|---|
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Clenbuterol; Cognitive Dysfun | 2021 |
Adrenoceptors in Dopaminergic Regulation of Rat Myocardial Contractility in Rats During Ontogeny.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Outbred Strains; | 2017 |
Implications of aging in the treatment of complex arrhythmias.
Topics: Aging; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Metoprolol; Propranolol | 2018 |
β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Blood Pressure; Body Temperature; Body Temperature | 2014 |
Effects of lifestyle changes and high-dose β-blocker therapy on exercise capacity in children, adolescents, and young adults with hypertrophic cardiomyopathy.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aging; Blood Pressure; Cardiomyopathy, Hypertrophic, | 2015 |
New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.
Topics: Aging; Animals; Animals, Newborn; Embryonic Development; Female; Fertilization in Vitro; Fluorescent | 2015 |
Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling.
Topics: Aging; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Central Nervous System Depressants; | 2015 |
Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aging; Blood Pressure; Female; Humans; Male; M | 2016 |
Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Female; Gene Expression Regulation; Kisspeptins; Ovary; | 2017 |
Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Association Learning; Cerebellum; Conditioning, Eyelid; | 2009 |
Role of {alpha}1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; | 2009 |
Periodic variation in R-R intervals and cardiovascular autonomic regulation in young adult Syrian hamsters.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Anti-Arrhythmia Agents; Atrop | 2009 |
Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Aging; Biopterins; Body Temp | 2009 |
Presynaptic interneuron subtype- and age-dependent modulation of GABAergic synaptic transmission by beta-adrenoceptors in rat insular cortex.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Cerebral Cor | 2010 |
[Ischemic heart disease in elderly patients of behavioral type A (psychosocial and clinic functional changes, possibilities for correction)].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Anti-Anxiety Agents; Behavioral Symptoms; Benzodiaz | 2011 |
Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Cells, Cul | 2012 |
Propranolol restores cognitive deficits and improves amyloid and Tau pathologies in a senescence-accelerated mouse model.
Topics: Adrenergic beta-Antagonists; Aging; Amyloid Neuropathies; Animals; Antihypertensive Agents; Biomarke | 2013 |
Different effects of acute clenbuterol on vasomotor response in mesenteric arteries from young and old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aging; Animals; Blood Pressure; Calcitonin G | 2003 |
Aging accelerates dietary lard-induced increase in blood pressure in rats.
Topics: Aging; Animals; Blood Glucose; Dietary Fats; Epinephrine; Glucose; Hypertension; Insulin; Insulin Re | 2003 |
Stress impairs alpha(1A) adrenoceptor-mediated noradrenergic facilitation of GABAergic transmission in the basolateral amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Adr | 2004 |
Effect of beta-adrenoceptor blockade on cardiac activity in rats during postnatal ontogeny.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Body Weight; Electrophysiology; Femoral Vein; Heart Rat | 2003 |
Age-dependent morphometrical changes in the thymus of male propranolol-treated rats.
Topics: Aging; Animals; Connective Tissue; Male; Organ Size; Propranolol; Rats; Sexual Maturation; Thymus Gl | 2004 |
Do incremental increases in blood pressure elicit neointimal plaques through endothelial injury?
Topics: Aging; Animals; Aorta, Abdominal; Arginine; Blood Pressure; Chickens; Disease Models, Animal; Endoth | 2004 |
Age-related differences in the response of blood stroke volume to stimulation of the sympathetic ganglion in rats with beta-adrenoceptor blockade.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Cardiac Output; Propranolol; Rats; Receptors, Adrenergi | 2004 |
Beta blockers for the treatment of primary hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Humans; Hypertension; Middle Aged; Myocardial Infar | 2006 |
Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Dose-Respo | 2006 |
[Characteristics of arrhythmia in elderly patients].
Topics: Aged; Aging; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Diagnosis, Different | 2006 |
Neural plasticity maintained high by activation of cyclic AMP-dependent protein kinase: an age-independent, general mechanism in cat striate cortex.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Brain Mapping; Bucladesine; Cats; Cholera Toxin; Cyclic | 2007 |
Depressed cardiac contractility and its postnatal development in rats after chemical sympathectomy.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Myocardial | 2008 |
Age-related changes of in vivo beta-adrenergic responsiveness in normotensive and spontaneously hypertensive rats.
Topics: Aging; Animals; Blood Pressure; Cyclic AMP; Hypertension; Isoproterenol; Male; Propranolol; Rats; Ra | 1984 |
Distribution and quantitative developmental changes in guinea pig pulmonary beta-receptors.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding Sites; Dihydroalprenolol; Guinea Pigs; Lu | 1984 |
Influence of smoking and age on pharmacokinetics of beta-receptor blockers.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Humans; Kinetics; Male; Middle Aged; Pindolol; Prop | 1982 |
Potassium homeostasis during hyperinsulinemia: effect of insulin level, beta-blockade, and age.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Homeostasis; Humans; Insulin; Male; Middle Aged; Po | 1982 |
The natural history of left ventricular hypertrophy in hypertrophic cardiomyopathy: an electrocardiographic study.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aging; Angina Pectoris; Cardiomyopathy, Hypertrophic | 1982 |
Selected phenotypic induction of null lymphocytes from mice with thymic and nonthymic agents.
Topics: Aging; Animals; Antigens, Surface; Cell Differentiation; Chromosomal Proteins, Non-Histone; Cyclic A | 1982 |
Beta-adrenergic regulation of rat parotid gland exocrine protein secretion during aging.
Topics: Aging; Amylases; Animals; Dihydroalprenolol; Dose-Response Relationship, Drug; In Vitro Techniques; | 1981 |
Secretion of alpha-amylase from parotid lobules of young and old rats.
Topics: Aging; Amylases; Animals; Isoproterenol; Male; Microscopy, Electron; Parotid Gland; Propranolol; Rat | 1982 |
Is the modality of the supersensitivity after sympathectomy age and duration dependent?
Topics: Aging; Amylases; Animals; Dose-Response Relationship, Drug; Ganglia, Sympathetic; Norepinephrine; Pa | 1984 |
Effect of clenbuterol, a new beta 2 selective adrenoceptor stimulant, on the release of histamine and SRS-A from passively sensitized guinea-pig chopped lungs.
Topics: Aging; Albuterol; Animals; Chromones; Clenbuterol; Ethanolamines; Guinea Pigs; Histamine Release; In | 1984 |
Human lymphocyte beta-adrenergic receptors are unaltered with age.
Topics: Adolescent; Adult; Aged; Aging; Dihydroalprenolol; Epinephrine; Female; Humans; Isoproterenol; Lymph | 1981 |
Adenylate cyclase and beta adrenergic receptor development in the mouse heart.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Dihydroalprenolol; Female; Fetal Heart; Heart; | 1982 |
Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats.
Topics: Aging; Animals; Cyclic AMP; Epinephrine; Isoproterenol; Liver; Male; Prazosin; Propranolol; Rats; Ra | 1983 |
Beta-adrenergic control of phosphatidylcholine synthesis by transmethylation in hepatocytes from juvenile, adult and adrenalectomized rats.
Topics: Adrenalectomy; Aging; Animals; Cyclic AMP; Ethanolamines; In Vitro Techniques; Insulin; Isoprotereno | 1983 |
Beta-1 and beta-2 adrenoceptor-mediated responses in preparations of pulmonary artery and aorta from young and aged rats.
Topics: Aging; Animals; Aorta; Cocaine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Tec | 1984 |
Effect of age and diet on insulin secretion and insulin action in the rat.
Topics: Aging; Animals; Dietary Carbohydrates; Epinephrine; Glucose; Glucose Tolerance Test; Hyperplasia; In | 1983 |
Effect of propranolol treatment in pregnant rats on motor activity and avoidance learning of the offspring.
Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Female; Fetal Hypoxia; Male; Motor Activity; P | 1983 |
Insulin resistance in older rats.
Topics: Aging; Animals; Blood Glucose; Body Composition; Epinephrine; Glycogen; Glycogen Synthase; Hindlimb; | 1984 |
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.
Topics: Aging; Airway Resistance; Animals; Bronchi; Cimetidine; Dimaprit; Female; Guanidines; Guinea Pigs; H | 1982 |
Noradrenergic influences on blocking: interactions with development.
Topics: Aging; Animals; Attention; Avoidance Learning; Conditioning, Operant; Female; Growth; Isoproterenol; | 1984 |
[Endogenous opioid peptides in borderline arterial hypertension].
Topics: Adolescent; Adult; Aging; Endorphins; Female; Hemodynamics; Humans; Hypertension; Male; Propranolol; | 1984 |
An investigation of the age-related deficits in the febrile response of the rabbit.
Topics: Aging; Animals; Body Temperature; Body Temperature Regulation; Endotoxins; Fever; Kinetics; Norepine | 1983 |
Influence of age on serum protein binding of propranolol.
Topics: Adolescent; Adult; Aged; Aging; Blood Proteins; Child; Humans; Male; Orosomucoid; Propranolol; Prote | 1984 |
Does insulin removal rate from plasma decline with age?
Topics: Adult; Aged; Aging; Animals; Epinephrine; Humans; Insulin; Male; Metabolic Clearance Rate; Middle Ag | 1982 |
Plasma triiodothyronine response to thyrotropin releasing hormone, thyrotropin and propranolol in old age.
Topics: Adult; Aged; Aging; Female; Humans; Male; Propranolol; Thyrotropin; Thyrotropin-Releasing Hormone; T | 1981 |
Thermoregulatory heat production in cold-reared and warm-reared pigs.
Topics: Acclimatization; Aging; Animals; Body Temperature Regulation; Cold Temperature; Hot Temperature; Nor | 1983 |
Sympathetic regulation of circadian rhythm of serotonin N-acetyltransferase activity in pineal gland of infant rat.
Topics: Acetyltransferases; Aging; Animals; Animals, Newborn; Arylamine N-Acetyltransferase; Circadian Rhyth | 1982 |
The comparative hemodynamic effects of propranolol in chronically instrumented puppies and adult dogs.
Topics: Aging; Animals; Blood Pressure; Cardiac Output; Dogs; Heart Rate; Hemodynamics; Isoproterenol; Kidne | 1982 |
Age-related changes in pineal "synaptic" ribbon populations in rats exposed to continuous light or darkness.
Topics: Aging; Animals; Darkness; Female; Isoproterenol; Light; Pineal Gland; Propranolol; Rats; Time Factor | 1982 |
The influences of glucagon, epinephrine and adrenergic agents on glycogen phosphorylase a and pyruvate kinase activities in hepatocytes from juvenile and adult rabbits.
Topics: Aging; Animals; Epinephrine; Glucagon; Isoproterenol; Liver; Male; Phentolamine; Phenylephrine; Phos | 1982 |
Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice.
Topics: Aging; Animals; Behavior, Animal; Clonidine; Digitoxin; Drug Interactions; Gait; Male; Mice; Postura | 1982 |
The rise and fall of pineal N-acetyltransferase in vitro: neural regulation in the developing rat.
Topics: Acetyltransferases; Aging; Animals; Circadian Rhythm; Ganglia, Sympathetic; Light; Muridae; Neural P | 1982 |
The possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people.
Topics: Adult; Aged; Aging; Female; Humans; Kinetics; Male; Propranolol; Thyrotropin; Thyroxine; Triiodothyr | 1982 |
Cardiovascular drugs for the geriatric patient.
Topics: Aged; Aging; Antihypertensive Agents; Cardiovascular Agents; Cardiovascular Physiological Phenomena; | 1981 |
Role of aortic input impedance in the decreased cardiovascular response to exercise with aging in dogs.
Topics: Aging; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dogs; Electric Conductiv | 1981 |
Ouabain-induced inotropism of isolated newborn and adult rabbit myocardium.
Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Heart; In Vitro Techniques; Myocardial Contr | 1981 |
Propranolol-induced alterations in the pathophysiology of spontaneously hypertensive rats.
Topics: Aging; Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Corticosterone; F | 1981 |
Evidences supporting an increased sympathetic tone and reactivity in a subgroup of patients with essential hypertension.
Topics: Adult; Aging; Blood Pressure; Catecholamines; Diagnosis, Differential; Epinephrine; Female; Heart Ra | 1980 |
Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant.
Topics: Adult; Aging; Blood Proteins; Contraceptives, Oral; Diazepam; Female; Humans; Infant, Newborn; Lidoc | 1981 |
Nitric oxide and beta-adrenergic mechanisms modify contractile responses to norepinephrine in ovine fetal and newborn cerebral arteries.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Arginine; Cerebral Arteries; Embryoni | 1995 |
[Changes in the number of alpha 2- and beta-adrenoreceptors in the brain stem and cerebral cortex of rats in ontogeny].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Brain Chemistry; Brain Stem; | 1995 |
Developmental changes of action potential configuration and I(to) in canine epicardium.
Topics: 4-Aminopyridine; Action Potentials; Aging; Animals; Cells, Cultured; Dogs; Fetus; Heart; Patch-Clamp | 1995 |
Effect of ageing and propranolol administration on myocardial beta-adrenoceptor receptor function in mature rats.
Topics: Age Factors; Aging; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Heart; Isoproterenol; Mal | 1995 |
Systolic functional response of normal older and younger adult left ventricles to beta-blockade during exercise.
Topics: Adult; Aged; Aging; Blood Pressure; Echocardiography; Electrocardiography; Exercise; Exercise Test; | 1995 |
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine; | 1995 |
The effect of different calcium antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes.
Topics: Aging; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Drug Interactions; Liver; Male; | 1994 |
Influence of autonomic blockade and aging on AV conduction and responses to verapamil in the beagle.
Topics: Aging; Animals; Atrioventricular Node; Atropine; Autonomic Nervous System; Blood Pressure; Dogs; Dos | 1995 |
Norepinephrine and posttraining memory consolidation in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Appetitive Behavior; Association Learning; Brain; Conditioning, Cl | 1994 |
Effects of acute beta-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Exercise; Hemodynamics; Humans; | 1994 |
Increased alpha 2-adrenoceptor mediated regulation of adult rat brain noradrenaline overflow after chronic neonatal exposure to propranolol; a microdialysis study.
Topics: Aging; Animals; Animals, Newborn; Biogenic Monoamines; Brain; Methoxyhydroxyphenylglycol; Microdialy | 1994 |
Norepinephrine-induced relaxations in rat aorta mediated by endothelial beta adrenoceptors. Impairment by ageing and hypertension.
Topics: Aging; Animals; Aorta; Arginine; Endothelium, Vascular; Hypertension; In Vitro Techniques; Isoproter | 1994 |
Alpha-2 adrenergic receptor activity in porcine adipocytes is androgen and age/cell size dependent.
Topics: Adipose Tissue; Aging; Androgens; Animals; Cell Size; Epinephrine; Isoproterenol; Lipolysis; Male; P | 1993 |
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes.
Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Carbachol; Cell Membrane; Cells, Cultured; Cyto | 1994 |
The effect of propranolol on salivary gland function and dental caries development in young and aged rats.
Topics: Aging; Alveolar Bone Loss; Animals; Dental Caries; Dental Caries Susceptibility; Dental Plaque; Diet | 1993 |
Nonlinearity of the left ventricular end-systolic wall stress-velocity of fiber shortening relation in young pigs: a potential pitfall in its use as a single-beat index of contractility.
Topics: Aging; Animals; Dobutamine; Echocardiography; Heart Rate; Hemodynamics; Linear Models; Myocardial Co | 1994 |
Changes in alpha 1-adrenoceptor coupling to Ca2+ channels during development in rat heart.
Topics: Aging; Animals; Animals, Newborn; Calcium Channels; Electric Conductivity; Heart; Membrane Potential | 1994 |
Cardiovascular hyporesponsiveness to norepinephrine, propranolol and nitroglycerin in portal-hypertensive and aged rats.
Topics: Aging; Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; | 1993 |
Age-related changes of sinus node function and autonomic regulation in subjects without sinus node disease--assessment by pharmacologic autonomic blockade.
Topics: Adolescent; Adult; Aged; Aging; Atropine; Autonomic Nerve Block; Autonomic Nervous System; Electroph | 1993 |
Assessment of 8-OH-DPAT induced spontaneous tailflicks as an in vivo model of 5-HT1A function in young rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Res | 1993 |
Effects of age on beta-adrenergic-mediated reflex responses to induced muscular contraction in beagles.
Topics: Aging; Animals; Cardiovascular System; Dogs; Hemodynamics; Muscle Contraction; Propranolol; Receptor | 1993 |
Influence of human recombinant interleukin-1 beta on the enantioselective disposition of propranolol in rats.
Topics: Aging; Animals; Humans; Interleukin-1; Kinetics; Male; Propranolol; Rats; Rats, Wistar; Recombinant | 1993 |
Lymphocyte norepinephrine and epinephrine, but not plasma catecholamines predict lymphocyte cAMP production.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Aged, 80 and over; Aging; Cyclic AMP; Epinephrine; Humans; | 1996 |
Differential adrenergic regulation of rat pineal cyclic AMP production and N-acetyltransferase activity during postnatal development: involvement of G alpha s and G alpha i1-2 proteins.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; An | 1997 |
The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; GTP-Binding P | 1998 |
Reduced DNA synthesis in primary cultures of hepatocytes from old mice is restored by thymus grafts.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Blood Physi | 1998 |
Beta-adrenoceptor-stimulated renin release is blunted in old rats.
Topics: Aging; Animals; Disease Models, Animal; Male; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Ad | 1998 |
Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats.
Topics: Adipocytes; Adrenocorticotropic Hormone; Aging; Animals; Dose-Response Relationship, Drug; Epinephri | 1973 |
Diabetic alteration of cardiac vago-sympathetic modulation assessed with tone-entropy analysis.
Topics: Adult; Aged; Aging; Atropine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 2; Electrocar | 1999 |
Aging alteration of cardiac vagosympathetic balance assessed through the tone-entropy analysis.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Atropine; Autonomic Nervous System; Efferent Pathwa | 1999 |
[Cardial output in rats of various ages during blocking of alpha1- and beta-adrenoreceptors].
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; | 1999 |
Developmental and pharmacological features of mouse emotional piloerection.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Behavior, Animal; Conditioning, Classical; Diazepam; E | 1999 |
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Aging; Animals; Calcium-Binding Proteins; Cardiomyop | 2001 |
Effects of L-phenylalanine on acetylcholinesterase and Na(+), K(+)-ATPase activities in adult and aged rat brain.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Bra | 2001 |
Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the changes with aging.
Topics: Aging; Aminoquinolines; Animals; Arginine; Atropine; Electric Stimulation; Guanethidine; Histocytoch | 2001 |
Aging alters neuronal nitric oxide release from rat mesenteric arteries: role of presynaptic beta-adrenoceptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Clenbuterol; Culture Techniqu | 2001 |
Influence of age, the autonomic nervous system and anxiety on QT-interval variability.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Analysis of Variance; Anti-Arrhythmia Agents; Anxie | 2001 |
Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Aging; Blood Pressure; Body | 2001 |
Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Body Fluids; Body Water; Catecholamin | 2002 |
Effects of neurotransmitters and neuropharmacological agents on phospholipid metabolism in the rabbit iris muscle.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Atropine; Ca | 1976 |
Beta-adrenergic receptor blocking drugs in spontaneous hypertension.
Topics: Adrenergic beta-Antagonists; Aging; Alprenolol; Animals; Blood Pressure; Hypertension; Male; Metopro | 1976 |
Age-dependent response of neonate fowls to peripheral noradrenaline.
Topics: Adrenal Glands; Aging; Animals; Animals, Newborn; Body Temperature; Chickens; Epinephrine; Male; Nor | 1976 |
[Essential hypertension: adrenergic control system, renin-angiotensin effector axis, kidney and age].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Angiotensin II; Catecholamines; Diuretics; Humans; | 1976 |
Renin and age as determinants of a predominantly betablocker-based antihypertensive drug program.
Topics: Adrenergic beta-Antagonists; Adult; Aging; Aldosterone; Angiotensin II; Antihypertensive Agents; Blo | 1976 |
Identification of beta adrenoreceptors during thymocyte ontogeny in mice.
Topics: Adrenergic beta-Agonists; Aging; Alprenolol; Animals; Binding Sites; Cyclic AMP; Cyclic GMP; Hydroge | 1979 |
Use of drugs in the aged.
Topics: Adolescent; Adult; Aged; Aging; Analgesics, Opioid; Benzodiazepines; Digoxin; Drug Therapy; Drug-Rel | 1979 |
Adrenergic control of glucose output and adenosine 3':5'-monophosphate levels in hepatocytes from juvenile and adult rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Cyclic AMP; Epinephrine; | 1979 |
Effects of beta-adrenoreceptor antagonists on sino-aortic baroreflex sensitivity and blood pressure in hypertensive man.
Topics: Acebutolol; Adolescent; Adrenergic beta-Agonists; Adult; Aging; Blood Pressure; Female; Heart Rate; | 1979 |
Medical management of angina pectoris.
Topics: Aging; Angina Pectoris; Arteriosclerosis; Coronary Disease; Diet; Humans; Hypnotics and Sedatives; N | 1979 |
Postnatal development of postganglionic parasympathetic neurones in the heart of the albino rat.
Topics: Acetylcholine; Action Potentials; Aging; Animals; Cholinesterase Inhibitors; Depression, Chemical; E | 1979 |
[Dynamics of plasma catecholamines and beta-adrenoreceptor functions. Use of a new radio-enzymatic micro-method].
Topics: Adult; Aging; Blood Pressure; Catecholamines; Dopamine; Epinephrine; Female; Humans; Male; Middle Ag | 1976 |
Airway response to adrenergic agonists and antagonists in 3-day- to 2-year-old rats.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Atropine; Bronchi; Bronchitis; Epinephrine; Female; | 1979 |
Noradrenaline secretion by the human kidney.
Topics: Aging; Aldosterone; Blood Pressure; Humans; Hypertension; Kidney; Norepinephrine; Propranolol; Renin | 1978 |
Effects of age and cigarette smoking on propranolol disposition.
Topics: Administration, Oral; Adult; Aged; Aging; Half-Life; Humans; Kinetics; Liver; Male; Middle Aged; Pro | 1979 |
Adrenergic control of glycolysis and pyruvate kinase activity in hepatocytes from young and old rats.
Topics: Aging; Animals; Epinephrine; Glucagon; Glucose; Glycolysis; In Vitro Techniques; Isoproterenol; Lact | 1979 |
Changes in coronary vascular resistance associated with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins.
Topics: Aging; Animals; Aspirin; Chloroquine; Coronary Circulation; Coronary Disease; In Vitro Techniques; I | 1979 |
[Nervous regulation of cardiac function during aging].
Topics: Acetylcholine; Aging; Animals; Atropine; Cardiac Output; Cats; Choline O-Acetyltransferase; Electric | 1977 |
Progressive postnatal changes in sinus node response to atropine and propranolol.
Topics: Aging; Animals; Animals, Newborn; Atropine; Depression, Chemical; Dogs; Heart Rate; Propranolol; Sin | 1978 |
Cardiac output changes during neonatal growth.
Topics: Aging; Animals; Animals, Newborn; Atropine; Cardiac Output; Female; Heart Rate; Isoproterenol; Propr | 1978 |
The effect of age and hyperthyroidism on plasma propranolol steady state concentration [proceedings].
Topics: Aging; Humans; Hyperthyroidism; Propranolol | 1978 |
Age-associated decrease in ventricular response to haemodynamic stress during beta-adrenergic blockade.
Topics: Adolescent; Adult; Aged; Aging; Blood Pressure; Heart; Heart Ventricles; Humans; Isometric Contracti | 1978 |
The effect of ageing on the hepatic clearance of propranolol.
Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Female; Half-Life; Humans; Inject | 1979 |
Tissue lipoprotein lipase in the hyperthyroid rat. Effect of growth and aging.
Topics: Adipose Tissue; Aging; Animals; Body Weight; Diaphragm; Fasting; Female; Heart; Hyperthyroidism; Lip | 1977 |
Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation.
Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Chlorisondami | 1977 |
Maximum exercise heart rate reduction with maturation in the rat.
Topics: Aging; Animals; Atropine; Electric Stimulation; Heart; Heart Rate; Male; Organ Size; Physical Exerti | 1976 |
Dual effects of aspirin in guinea-pig lungs.
Topics: Aging; Animals; Aspirin; Bronchi; Constriction, Pathologic; Female; Guinea Pigs; In Vitro Techniques | 1976 |
Reinstatement of vaginal cycles in aged female rats.
Topics: Aging; Animals; Benserazide; Carbidopa; Dose-Response Relationship, Drug; Drug Interactions; Estrus; | 1976 |
Clinical pharmacokinetics in infants and children.
Topics: Aging; Body Water; Carbamazepine; Child; Child, Preschool; Clindamycin; Dextropropoxyphene; Diazoxid | 1976 |
Relationship between central and autonomic nervous system activity: correlates of psychomotor performance in elderly men.
Topics: Aged; Aging; Arousal; Autonomic Nervous System; Central Nervous System; Contingent Negative Variatio | 1976 |
Geriatric cardiovascular problems.
Topics: Aged; Aging; Anesthesia; Arrhythmias, Cardiac; Blood Circulation; Cardiovascular Physiological Pheno | 1976 |
Prolonged contraction duration in aged myocardium.
Topics: Action Potentials; Aging; Animals; Catecholamines; Electric Stimulation; Heart; Hydroxydopamines; Hy | 1975 |
Changes in cardiac membranes as a function of age with particular emphasis on reactivity to drugs.
Topics: Action Potentials; Aging; Animals; Heart; Heart Conduction System; Heart Rate; Hydroxydopamines; In | 1975 |
Changes in myocardial collagen in normal development and after beta blockade.
Topics: Aging; Animals; Collagen; Fetus; Heart; Heart Ventricles; Myocardium; Organ Size; Practolol; Propran | 1975 |
The effect of age on plasma levels of propranolol and practolol in man.
Topics: Administration, Oral; Adult; Aged; Aging; Female; Half-Life; Humans; Male; Practolol; Propranolol | 1975 |
Influence of animal age on the beta-adrenergic system in cultured rat aortic and mesenteric artery smooth muscle cells.
Topics: Aging; Alprostadil; Animals; Aorta, Thoracic; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response | 1992 |
Age and beta-adrenergic receptor sensitivity to S(-)- and R,S(+/-)-propranolol in humans.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Blood Pressure; Heart Rate; Humans; Isoprotereno | 1992 |
Age-related delay in recovery of beta-adrenergic sensitivity after abrupt propranolol withdrawal in rats.
Topics: Aging; Animals; Blood Pressure; Drug Resistance; Epinephrine; Heart Rate; Male; Phenylephrine; Propr | 1992 |
Influence of age on the beta 1- and beta 2-adrenergic receptors in rat liver.
Topics: Adenylyl Cyclases; Aging; Animals; Binding, Competitive; Cell Membrane; Imidazoles; Liver; Liver Gly | 1992 |
Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines.
Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Aging; Animals; Arginine Vasopressin; Cate | 1992 |
[A comparative evaluation of the effect of anaprilin and teonikol on thrombocyte aggregation indices in patients with ischemic heart disease from older age groups].
Topics: Adrenal Cortex Hormones; Aged; Aging; Drug Evaluation; Female; Humans; Male; Middle Aged; Myocardial | 1992 |
Lack of effect of ageing on the stereochemical disposition of propranolol.
Topics: Adult; Aged; Aging; Humans; Liver Circulation; Male; Metabolic Clearance Rate; Propranolol; Stereois | 1992 |
Age and propranolol stereoselective disposition in humans.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Humans; Male; Metabolic Cl | 1992 |
Age and gender influence the stereoselective pharmacokinetics of propranolol.
Topics: Administration, Oral; Adult; Aged; Aging; Blood Proteins; Female; Humans; Male; Orosomucoid; Propran | 1992 |
The influence of aging on the stereoselective pharmacokinetics of propranolol in the rat.
Topics: Administration, Oral; Aging; Animals; Hematocrit; Injections, Intravenous; Male; Propranolol; Rats; | 1992 |
Effect of age on presynaptic beta2 receptor mediated responses in the rat heart.
Topics: Aging; Animals; Heart; Homeostasis; In Vitro Techniques; Male; Norepinephrine; Perfusion; Propranolo | 1991 |
Amphetamine actions on pre- and postpubertal rat hippocampal dentate granule neurons.
Topics: Aging; Animals; Atenolol; Calcium Channels; Cocaine; Dextroamphetamine; Evoked Potentials; Haloperid | 1991 |
Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Dopamine; Neurotoxins; Norepinephrine; Ornithine | 1991 |
Effects of chronic administration of carteolol on beta-adrenoceptors in spontaneously hypertensive rat heart.
Topics: Aging; Animals; Binding Sites; Blood Pressure; Carteolol; Dihydroalprenolol; Heart Rate; Hypertensio | 1991 |
Alterations in beta adrenergic and muscarinic receptors in aged rat heart. Effects of chronic administration of propranolol and atropine.
Topics: Aging; Animals; Atropine; Heart; Infusion Pumps, Implantable; Male; Myocardium; Propranolol; Rats; R | 1991 |
[The characteristics of the tension of neurohumoral regulation during the physical loading of dogs].
Topics: Aging; Animals; Clonidine; Dinoprostone; Dogs; Hormones; Male; Neurotransmitter Agents; Physical Exe | 1991 |
Hepatic beta-adrenoceptor adaptation during propranolol administration is impaired in aging rats.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; | 1991 |
Beta adrenergically mediated cardiac chronotropic and vascular smooth muscle responses during propranolol therapy and withdrawal in young and elderly persons.
Topics: Adult; Aged; Aging; Blood Pressure; Female; Heart Rate; Humans; Isoproterenol; Male; Muscle, Smooth, | 1992 |
Effect of age on the kinetics of the binding of iodocyanopindolol to a membrane preparation of rat lungs.
Topics: Aging; Animals; In Vitro Techniques; Iodocyanopindolol; Lung; Pindolol; Propranolol; Rats; Temperatu | 1991 |
Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure.
Topics: Adult; Aging; Atropine; Autonomic Nervous System Diseases; Blood Pressure; Female; Heart Rate; Human | 1991 |
Agonist-induced Ca2+ mobilization in the rat submandibular gland during aging and subsequent to chronic propranolol treatment.
Topics: Aging; Animals; Calcium; Carbachol; Female; In Vitro Techniques; Intracellular Fluid; Isoproterenol; | 1991 |
Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries.
Topics: Aging; Animals; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Endothe | 1991 |
Differential age-dependent attenuation of reflex tachycardia by verapamil in rats.
Topics: Aging; Animals; Atropine; Female; Heart Rate; Nitroprusside; Parasympathetic Nervous System; Phenyle | 1991 |
Ontogeny of renal beta adrenoceptors in the sheep.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Binding, Competitive; Ethanol | 1990 |
[Beta-adrenoblockaders and calcium antagonists in the treatment of patients with ischemic heart disease combined with hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Calcium Channel Blockers; Coronary Disease; Drug Ev | 1990 |
Essential tremor: clinical correlates in 350 patients.
Topics: Adult; Aged; Aging; Alcohol Drinking; Female; Humans; Male; Middle Aged; Movement Disorders; Primido | 1991 |
Hepatic microsomal propranolol metabolism in aging male and female rats.
Topics: Aging; Animals; Dealkylation; Female; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; P | 1991 |
Autonomic regulation of reflex bradycardia in rats declines with age.
Topics: Aging; Animals; Atropine; Autonomic Nervous System; Female; Heart Rate; Nitroprusside; Parasympathet | 1991 |
The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts.
Topics: Aging; Animals; Drug Interactions; Electrophysiology; Heart Conduction System; Injections, Intraperi | 1991 |
Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam.
Topics: Adult; Aged; Aging; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diazepam; Drug | 1990 |
Peculiarities of neural regulation of the thyroid, adrenocortical and testicular functions in old age.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aging; Animals; Atropine; Dibenzylchlorethamine; Ketost | 1990 |
Effect of aging on the response of guinea pig trachea to isoprenaline.
Topics: Aging; Animals; Corticosterone; Dihydroalprenolol; Guinea Pigs; In Vitro Techniques; Isoproterenol; | 1990 |
Brown adipose tissue thermogenic responses of rats induced by central stimulation: effect of age and cold acclimation.
Topics: Acclimatization; Adipose Tissue, Brown; Aging; Animals; Blood Pressure; Body Temperature Regulation; | 1990 |
Enhanced sympathetic mediation of chronotropic baroreflexes in old Sprague-Dawley rats.
Topics: Aging; Animals; Atropine Derivatives; Blood Pressure; Efferent Pathways; Heart Rate; Male; Nitroprus | 1990 |
Effect of aging on the pharmcokinetics of atenolol, metoprolol and propranolol in the rat.
Topics: Aging; Animals; Antipyrine; Atenolol; Male; Metabolic Clearance Rate; Metoprolol; Orosomucoid; Propr | 1990 |
The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats.
Topics: Aging; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; M | 1990 |
Ontogeny of isoproterenol-stimulated renin secretion from sheep renal cortical slices.
Topics: Aging; Animals; Animals, Newborn; Aspirin; Edetic Acid; Fetus; Gestational Age; Isoproterenol; Kidne | 1989 |
Resting heart rates in an ambulatory elderly population: an evaluation of age, sex, symptoms, and medication.
Topics: Aged; Aging; Blood Pressure; Digoxin; Female; Heart Rate; Humans; Male; Nitroglycerin; Propranolol; | 1989 |
Dissociation between c-fos gene expression and DNA synthesis in rat parotid glands.
Topics: Aging; Animals; Blotting, Northern; Carbachol; DNA; Epinephrine; Gene Expression; Isoproterenol; Mal | 1989 |
Lipolytic response of bovine adipose tissue to alpha and beta adrenergic agents 30 days pre- and 120 days postpartum.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; A | 1989 |
Specific age-dependence in capacity-limited uptake of propranolol by isolated rat lung.
Topics: Aging; Animals; In Vitro Techniques; Lung; Male; Propranolol; Rats; Rats, Inbred Strains | 1989 |
Interaction of noradrenergic and cholinergic systems in regulation of ocular dominance plasticity.
Topics: Aging; Animals; Bethanechol; Bethanechol Compounds; Cats; Cholinergic Fibers; Dose-Response Relation | 1989 |
Ontogeny of neuronally released norepinephrine on renin secretion in sheep.
Topics: Aging; Animals; Animals, Newborn; Fetus; In Vitro Techniques; Kidney Cortex; Kinetics; Neurons; Nore | 1989 |
Stereoselective binding of propranolol in the elderly.
Topics: Adult; Aged; Aging; Blood Proteins; Dialysis; Humans; Male; Orosomucoid; Propranolol; Protein Bindin | 1989 |
Effects of aging on agonist-activated 86Rb efflux in arteries of Fischer 344 rats.
Topics: Aging; Animals; Aorta, Thoracic; Arteries; Male; Mesenteric Arteries; Muscle Development; Muscle, Sm | 1989 |
The effects of ageing on neuronal uptake of noradrenaline in the rat.
Topics: Aging; Animals; Cocaine; Corticosterone; Decerebrate State; Heart; Heart Rate; Hemodynamics; Isoprot | 1989 |
Emergence of beta adrenergic-responsive hepatic glycogenolysis in male rats during post-maturational aging.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Epinephrine; Glucagon; Glucose; Gly | 1987 |
Noradrenergic modulation of olfactory bulb excitability in the postnatal rat.
Topics: Action Potentials; Aging; Animals; Electric Stimulation; Female; Isoproterenol; Male; Norepinephrine | 1988 |
In vivo demonstration of maturational changes of the chronotropic response to alpha-adrenergic stimulation.
Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Dogs; Heart Rate; Parasympathetic Nervous System; | 1988 |
[Influence of hypertension and age on the sympathetic and parasympathetic components of cardiac baroreflex in the conscious rat].
Topics: Aging; Animals; Atropine; Heart; Hypertension; Male; Parasympathetic Nervous System; Phenylephrine; | 1988 |
[Transport of univalent cations across the erythrocyte membrane of hypertensive rats of various ages].
Topics: Aging; Animals; Biological Transport; Calcium Channels; Cations, Monovalent; Culture Media; Erythroc | 1988 |
Isoproterenol-sensitive adenylate cyclase in glomeruli isolated from young and adult rat renal cortex.
Topics: Adenylyl Cyclases; Aging; Alkaline Phosphatase; Animals; Enzyme Activation; Fluorides; gamma-Glutamy | 1985 |
Effect of age on the hepatic clearance of propranolol in rats.
Topics: Administration, Oral; Aging; Animals; Blood Proteins; Injections, Intravenous; Kidney; Kinetics; Liv | 1985 |
Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Bromazepam; Cimetidine; Contraceptive | 1987 |
Influence of beta-adrenoceptor-mediated relaxation on alpha-adrenoceptor-mediated contraction of rat pulmonary artery to adrenaline or noradrenaline.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Male; Norepineph | 1987 |
Effect of beta-adrenergic receptor blockade on responses to acute hypoxemia in lambs.
Topics: Acute Disease; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Cardiac Output; Heart | 1988 |
Age-dependent pulmonary first-pass elimination of propranolol in rats.
Topics: Aging; Animals; Half-Life; Injections, Intravenous; Lung; Male; Propranolol; Rats; Rats, Inbred Stra | 1988 |
Age-dependent beta-adrenergic response of neuronal discharge in the raphe dorsalis: evidence of a transient regulation.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Electrophysiology; Neurons; Propranol | 1988 |
Lymphocyte protein kinase activity in cells from young and elderly men and women.
Topics: Adult; Aged; Aging; Colforsin; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; Humans; Isoprotere | 1985 |
Developmental alteration in adrenergic regulation of hepatic glycogen phosphorylase.
Topics: Aging; Animals; Cyclic AMP; Epinephrine; In Vitro Techniques; Isoproterenol; Liver; Liver Glycogen; | 1986 |
Regulation of beta adrenergic receptors on rat mononuclear leukocytes by stress: receptor redistribution and down-regulation are altered with aging.
Topics: Aging; Animals; Cyclic AMP; Dihydroalprenolol; Isoproterenol; Male; Monocytes; Propanolamines; Propr | 1987 |
[Age dependent quantitative evaluations of sensitivity changes in beta adrenergic receptors to isoprenaline and propranolol].
Topics: Adult; Aged; Aging; Humans; Isoproterenol; Male; Middle Aged; Propranolol; Receptors, Adrenergic, be | 1986 |
Age-related change in alpha-adrenergic responsiveness of the urinary bladder of the rat is regionally specific.
Topics: Aging; Animals; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potas | 1986 |
Desipramine and noradrenergic neurotransmission in aging: failure to respond in aged laboratory animals.
Topics: Action Potentials; Aging; Animals; Desipramine; Electric Stimulation; Hydroxydopamines; Male; Norepi | 1987 |
The influence of age on human pancreatic growth hormone releasing hormone stimulated growth hormone secretion.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Hum | 1988 |
Early postnatal treatment with propranolol affects development of brain amines and behavior.
Topics: Acoustic Stimulation; Aging; Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Biogenic | 1988 |
Regulation of lipolysis during the neonatal period. Importance of thyrotropin.
Topics: Adenosine Deaminase; Adipose Tissue; Adult; Aging; Child; Child, Preschool; Epinephrine; Gestational | 1988 |
Electrophysiologic effects of intravenous propranolol in the intact immature mammalian heart.
Topics: Aging; Animals; Animals, Newborn; Bundle of His; Dogs; Electric Stimulation; Electrophysiology; Fema | 1988 |
Developmental changes in the effects of nadolol on adult and neonatal canine Purkinje fibers.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Heart Conduction System; In Vitro Techniq | 1988 |
Transplantation of norepinephrine neurons into aged rats improves performance of a learned task.
Topics: Aging; Animals; Avoidance Learning; Brain; Fetus; Male; Memory; Microscopy, Fluorescence; Neurons; N | 1988 |
Age-dependent changes in the response of isolated beagle coronary arteries to transmural electrical stimulation and catecholamines.
Topics: Acetylcholine; Aging; Animals; Catecholamines; Coronary Circulation; Coronary Vessels; Dinoprost; Do | 1986 |
Age-dependence in capacity-limited uptake kinetics of propranolol by isolated rat hepatocytes.
Topics: Aging; Animals; Cell Survival; Culture Media; Kinetics; Liver; Male; Propranolol; Rats; Rats, Inbred | 1986 |
Age dependence of adenylate cyclase in guinea pig ureter homogenate.
Topics: Adenylyl Cyclases; Aging; Alprostadil; Animals; Colforsin; Enzyme Activation; Ethanol; Guanosine Tri | 1986 |
Developmental changes in the effects of beta-adrenergic blocking concentrations of propranolol on canine Purkinje fibers.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Dogs; Heart Conduction System; Isoproterenol; P | 1986 |
The effect of ageing and disease on tear constituents.
Topics: Adult; Aged; Aging; Blepharitis; Ceruloplasmin; Eyelid Diseases; Humans; Immunoglobulin A; Immunoglo | 1985 |
Effect of chronic treatment of propranolol on lipid metabolism in spontaneously hypertensive rats (SHR).
Topics: Aging; Animals; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Fatty Acids, Nonesterified; | 1985 |
Age-dependent propranolol clearance in perfused rat liver.
Topics: Aging; Animals; Liver; Male; Metabolic Clearance Rate; Perfusion; Propranolol; Rats; Rats, Inbred St | 1986 |
Reactivity of small vessels from mature to senescent female rabbits.
Topics: Aging; Angiotensin II; Animals; Ear; Female; Femoral Artery; Histamine; Muscle Contraction; Muscle, | 1985 |
Electrophysiological analysis of the nature of adrenoceptors in the rat basilar artery during development.
Topics: Action Potentials; Aging; Animals; Basilar Artery; Female; Iontophoresis; Isoproterenol; Male; Membr | 1985 |
Metabolic responses to cold and catecholamines as a function of age in swine (Sus domesticus).
Topics: Adrenal Glands; Aging; Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Body Temperature Re | 1973 |
Regulation of the adenosine cyclic 3',5'-monophosphate content of rat cerebral cortex: ontogenetic development of the responsiveness to catecholamines and adenosine.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Adrenergic alp | 1973 |
Heart rate after combined vagal and sympathetic blockade with atropine and different beta-receptor blocking agents.
Topics: Adrenergic beta-Antagonists; Adult; Aging; Atropine; Dose-Response Relationship, Drug; Electrocardio | 1973 |
Age differences in the baroreceptor response of rats.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Atropine; Blood Pressure; Cardiac Output; Heart Rate; I | 1974 |
The "natural" history of severe angina pectoris with intensive medical therapy alone: a five year prospective study of 133 patients.
Topics: Adult; Aged; Aging; Angina Pectoris; Atrial Fibrillation; Cardiomegaly; Cerebrovascular Disorders; D | 1974 |
Neuroendocrine control of the cyclic AMP system of brain and pineal gland.
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Circadian Rhythm; Cyclic AMP; Kinetics; Light; Norepinephr | 1972 |
Increased sensitivity of sinoatrial pace-maker to acetylcholine and to catecholamines at the onset of autonomic neuroeffector transmission in chick embryo heart.
Topics: Acetylcholine; Aging; Animals; Atropine; Autonomic Fibers, Postganglionic; Chick Embryo; Electric St | 1974 |
[Prevention and general therapy of coronary insufficiency].
Topics: Aged; Aging; Angina Pectoris; Anticoagulants; Coronary Disease; Ethanolamines; Humans; Middle Aged; | 1971 |
Cardiac performance in the unanesthetized senescent male rat.
Topics: Aging; Animals; Arteries; Blood Pressure; Cardiac Output; Female; Heart; Heart Rate; Male; Propranol | 1973 |
Renin-like activity in submaxillary gland in several strains of rats including the spontaneously hypertensive rat.
Topics: Aging; Animals; Blood Pressure; Female; Hypertension; Kidney; Male; Nephrectomy; Propranolol; Rats; | 1972 |
Heart rate changes with age in chickens.
Topics: Aging; Animals; Atropine; Chickens; Electrocardiography; Female; Heart Rate; Injections, Intravenous | 1972 |
Properties of adenylate cyclase from senescent rat brain.
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Caudate Nucleus; Cell-Free System; Cerebellum; Cerebral Co | 1973 |
Heart rate and haemodynamics after autonomic blockade in infants and children.
Topics: Adolescent; Aging; Atropine; Autonomic Nerve Block; Cardiac Catheterization; Child; Child, Preschool | 1970 |
[Therapy of acute myocardial infarct with particular reference to arrhythmia and myocardial contractibility disorders].
Topics: Adult; Aged; Aging; Arrhythmias, Cardiac; Atropine; Cardiac Glycosides; Cortisone; Electric Counters | 1971 |
The release of a bradykinin-like pulmonary vasodilator substance in foetal and new-born lambs.
Topics: Aging; Animals; Animals, Newborn; Atropine; Bradykinin; Female; Fetus; Glass; Injections, Intra-Arte | 1968 |