propranolol has been researched along with Acute Brain Injuries in 32 studies
Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propranolol in vivo increased cerebral perfusion and decreased cerebral hypoxia." | 7.75 | The in vivo effect of propranolol on cerebral perfusion and hypoxia after traumatic brain injury. ( Conti, PS; Dagliyan, G; Ley, EJ; Margulies, DR; Park, R; Salim, A; Scehnet, J; Schroff, S, 2009) |
| " The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation." | 7.70 | Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999) |
| " This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha1-NA antagonist, or propranolol (PROP), a beta-NA antagonist, would continue to reinstate hemiplegia over time after recovery from weight-drop traumatic brain injury (TBI)." | 5.31 | Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury. ( Feeney, DM; Stibick, DL, 2001) |
| "The propranolol was continued until all signs of autonomic dysfunction abated." | 5.29 | Fever of central origin in traumatic brain injury controlled with propranolol. ( Meythaler, JM; Stinson, AM, 1994) |
| " We have provided experimental evidence showing the suppressive effects of the nonselective β-adrenoreceptor antagonist propranolol on hyperglycemia, inflammation, and brain injury in a rat model experiencing cerebral ischemia." | 3.96 | Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke. ( Chang, CY; Chen, CJ; Chen, WY; Kuan, YH; Liao, SL; Lin, SY; Wang, YY; Wu, CC, 2020) |
| " We hypothesize that judicious early low-dose propranolol after TBI (EPAT) will improve outcomes without altering bradycardia or hypotensive events." | 3.83 | Prospective evaluation of early propranolol after traumatic brain injury. ( Barmparas, G; Bloom, MB; Bukur, M; Harada, MY; Hoang, DM; Inaba, K; Ley, EJ; Margulies, DR; Murry, JS; Salim, A, 2016) |
| "Propranolol in vivo increased cerebral perfusion and decreased cerebral hypoxia." | 3.75 | The in vivo effect of propranolol on cerebral perfusion and hypoxia after traumatic brain injury. ( Conti, PS; Dagliyan, G; Ley, EJ; Margulies, DR; Park, R; Salim, A; Scehnet, J; Schroff, S, 2009) |
| " The following case report describes a patient developing neuroleptic malignant syndrome (NMS) secondary to the use of haloperidol given to control the patient's agitation." | 3.70 | Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury. ( Guin-Renfroe, S; Meythaler, JM; Wilkinson, R, 1999) |
| ") has been studied in 10 patients with various forms of hypertension under four different conditions: before and after salt depletion and with or without propranolol treatment." | 3.65 | Renin dependency of blood-pressure. Analysis by angiotensin II antagonist P113 in hypertensive patients treated with salt depletion and propranolol. ( Boer, P; Dorhout Mees, EJ; Geyskes, GG; Vos, J, 1976) |
| "Migraine is a hereditary disorder afflicting 5 per cent of school-age children." | 2.37 | Migraine in children. ( Fenichel, GM, 1985) |
| "Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg." | 1.72 | MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022) |
| " Administration of early propranolol was dosed within 24 hours of admission at 1 mg intravenous every 6 hours." | 1.43 | Early propranolol after traumatic brain injury is associated with lower mortality. ( Alban, RF; Barmparas, G; Bloom, MB; Chung, R; Harada, MY; Ko, A; Ley, EJ; Margulies, DR; Melo, N; Thomsen, GM, 2016) |
| "Propranolol patients were younger (30 years vs." | 1.40 | Traumatic brain injury and β-blockers: not all drugs are created equal. ( Clement, LP; Croce, MA; Fabian, TC; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP; Weinberg, JA, 2014) |
| " This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha1-NA antagonist, or propranolol (PROP), a beta-NA antagonist, would continue to reinstate hemiplegia over time after recovery from weight-drop traumatic brain injury (TBI)." | 1.31 | Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury. ( Feeney, DM; Stibick, DL, 2001) |
| "The propranolol was continued until all signs of autonomic dysfunction abated." | 1.29 | Fever of central origin in traumatic brain injury controlled with propranolol. ( Meythaler, JM; Stinson, AM, 1994) |
| "Pretreatment with propranolol produced a significant decrease in the prevalence of ascites compared with trauma alone (P less than 0." | 1.27 | Neurogenic hyperacute ascites in mice. ( Bensch, KG; Morin, ME; Murphy, BJ; Nelson, DP; Robin, ED; Theodore, J; Wong, RJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (34.38) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Wallen, TE | 1 |
| Baucom, MR | 1 |
| England, LG | 1 |
| Schuster, RM | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 1 |
| Lin, SY | 1 |
| Wang, YY | 1 |
| Chang, CY | 1 |
| Wu, CC | 1 |
| Chen, WY | 1 |
| Kuan, YH | 1 |
| Liao, SL | 1 |
| Chen, CJ | 1 |
| Yamada, H | 1 |
| Kikuchi, R | 1 |
| Katayama, J | 1 |
| Nakamura, A | 1 |
| Miyazaki, H | 1 |
| Schroeppel, TJ | 2 |
| Sharpe, JP | 1 |
| Magnotti, LJ | 1 |
| Weinberg, JA | 1 |
| Clement, LP | 1 |
| Croce, MA | 2 |
| Fabian, TC | 2 |
| Godoy, DA | 1 |
| Piñero, GR | 1 |
| Masotti, L | 1 |
| Murry, JS | 1 |
| Hoang, DM | 1 |
| Barmparas, G | 2 |
| Harada, MY | 2 |
| Bukur, M | 2 |
| Bloom, MB | 2 |
| Inaba, K | 1 |
| Margulies, DR | 5 |
| Salim, A | 4 |
| Ley, EJ | 5 |
| Kota, DJ | 1 |
| Prabhakara, KS | 1 |
| van Brummen, AJ | 1 |
| Bedi, S | 1 |
| Xue, H | 1 |
| DiCarlo, B | 1 |
| Cox, CS | 1 |
| Olson, SD | 1 |
| Ko, A | 1 |
| Thomsen, GM | 1 |
| Alban, RF | 1 |
| Chung, R | 1 |
| Melo, N | 1 |
| Scehnet, J | 1 |
| Park, R | 3 |
| Schroff, S | 1 |
| Dagliyan, G | 3 |
| Conti, PS | 3 |
| Palestrant, D | 1 |
| Miller, CM | 1 |
| Clond, MA | 1 |
| Chervonski, M | 1 |
| Lyden, PD | 1 |
| Patel, MB | 1 |
| McKenna, JW | 1 |
| Alvarez, JM | 1 |
| Sugiura, A | 1 |
| Jenkins, JM | 1 |
| Guillamondegui, OD | 1 |
| Pandharipande, PP | 1 |
| Fleminger, S | 2 |
| Greenwood, RJ | 2 |
| Oliver, DL | 2 |
| Mansheim, P | 1 |
| Meythaler, JM | 2 |
| Stinson, AM | 1 |
| Woiciechowsky, C | 1 |
| Asadullah, K | 1 |
| Nestler, D | 1 |
| Eberhardt, B | 1 |
| Platzer, C | 1 |
| Schöning, B | 1 |
| Glöckner, F | 1 |
| Lanksch, WR | 1 |
| Volk, HD | 1 |
| Döcke, WD | 1 |
| Wilkinson, R | 1 |
| Guin-Renfroe, S | 1 |
| Stibick, DL | 1 |
| Feeney, DM | 1 |
| Geyskes, GG | 1 |
| Boer, P | 1 |
| Vos, J | 1 |
| Dorhout Mees, EJ | 1 |
| Ellison, PH | 1 |
| Elliott, FA | 1 |
| Lewis, AB | 1 |
| Nestor, L | 1 |
| Dahms, B | 1 |
| Platzker, AC | 1 |
| Brooke, MM | 1 |
| Patterson, DR | 1 |
| Questad, KA | 1 |
| Cardenas, D | 1 |
| Farrel-Roberts, L | 1 |
| Griepp, EB | 1 |
| Griepp, RB | 1 |
| Nelson, DP | 1 |
| Robin, ED | 1 |
| Wong, RJ | 1 |
| Morin, ME | 1 |
| Bensch, KG | 1 |
| Murphy, BJ | 1 |
| Theodore, J | 1 |
| Fenichel, GM | 1 |
| Ulrich, G | 1 |
| Uchida, M | 1 |
| Yamaoka, H | 1 |
| Vander Ark, GD | 1 |
| Norton, LW | 1 |
| Pomerantz, M | 1 |
| Dasgupta, NK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status: A Randomized Controlled Trial (BBTBBT)[NCT04508244] | Phase 4 | 771 participants (Anticipated) | Interventional | 2020-12-29 | Recruiting | ||
| DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Severe Traumatic Brain Injury, A Pilot Randomized Clinical Trial Using Propranolol and Clonidine[NCT01322048] | Phase 2 | 48 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Controlling Hyperadrenergic Activity in Neurologic Injury[NCT01343329] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2011-07-31 | Withdrawn (stopped due to Unable to enroll subjects that fit study criteria.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01322048)
Timeframe: Post-treatment (t=Day 8)
| Intervention | pg/mL (Median) |
|---|---|
| Adrenergic Blockade | 962 |
| Placebo | 714 |
(NCT01322048)
Timeframe: Baseline to day 28
| Intervention | days (Median) |
|---|---|
| Adrenergic Blockade | 16.2 |
| Placebo | 18.05 |
4 reviews available for propranolol and Acute Brain Injuries
| Article | Year |
|---|---|
Pharmacological management for agitation and aggression in people with acquired brain injury.
Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat | 2003 |
Pharmacological management for agitation and aggression in people with acquired brain injury.
Topics: Adrenergic beta-Antagonists; Aggression; Amantadine; Anxiety; Brain Injuries; Humans; Methylphenidat | 2006 |
Cerebral consequences of hypothermic circulatory arrest in adults.
Topics: Animals; Barbiturates; Body Temperature; Brain; Brain Injuries; Calcium Channel Blockers; Clinical T | 1992 |
Migraine in children.
Topics: Adolescent; Basilar Artery; Brain Injuries; Cerebrovascular Circulation; Child; Child, Preschool; Co | 1985 |
2 trials available for propranolol and Acute Brain Injuries
| Article | Year |
|---|---|
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Biomarkers; Br | 2012 |
The treatment of agitation during initial hospitalization after traumatic brain injury.
Topics: Aggression; Brain Injuries; Humans; Propranolol; Psychomotor Agitation; Restraint, Physical | 1992 |
26 other studies available for propranolol and Acute Brain Injuries
| Article | Year |
|---|---|
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th | 2022 |
Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke.
Topics: Adrenergic beta-Antagonists; Animals; Brain Injuries; Cell Line; Cytokines; Disease Models, Animal; | 2020 |
Paroxysmal Sympathetic Hyperactivity after Surgery for Cerebral Hemorrhagic Arteriovenous Malformation: A Case Report.
Topics: Adolescent; Adrenergic beta-Antagonists; Amines; Autonomic Nervous System Diseases; Brain Injuries; | 2018 |
Traumatic brain injury and β-blockers: not all drugs are created equal.
Topics: Adrenergic beta-Antagonists; Adult; Brain Injuries; Cause of Death; Cohort Studies; Confidence Inter | 2014 |
Paroxysmal sympathetic hyperactivity, traumatic brain injury, and β-blockers.
Topics: Adrenergic beta-Antagonists; Brain Injuries; Female; Hospital Mortality; Humans; Male; Primary Dysau | 2014 |
Re: Paroxysmal sympathetic hyperactivity, traumatic brain injury, and β-blockers: Not all drugs are created equal.
Topics: Adrenergic beta-Antagonists; Brain Injuries; Female; Hospital Mortality; Humans; Male; Primary Dysau | 2014 |
Prospective evaluation of early propranolol after traumatic brain injury.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Bradycardia; Brain Injuries; Drug Administration Schedule; | 2016 |
Propranolol and Mesenchymal Stromal Cells Combine to Treat Traumatic Brain Injury.
Topics: Adult; Allografts; Animals; Bone Marrow Cells; Brain Injuries; Humans; Male; Mesenchymal Stem Cell T | 2016 |
Early propranolol after traumatic brain injury is associated with lower mortality.
Topics: Abbreviated Injury Scale; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brain Injurie | 2016 |
The in vivo effect of propranolol on cerebral perfusion and hypoxia after traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Cerebrovascular Circulation; Hypoxia; Immunohistochem | 2009 |
In vivo effect of propranolol dose and timing on cerebral perfusion after traumatic brain injury.
Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Mice; Mice, | 2010 |
β-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury.
Topics: Adrenergic beta-Antagonists; Animals; Blotting, Western; Brain; Brain Chemistry; Brain Injuries; Glu | 2012 |
Treatment with propranolol of the behavioral sequelae of brain damage.
Topics: Adult; Brain Injuries; Female; Humans; Neurocognitive Disorders; Propranolol; Social Behavior Disord | 1981 |
Fever of central origin in traumatic brain injury controlled with propranolol.
Topics: Accidents, Traffic; Adolescent; Adult; Body Temperature Regulation; Brain Injuries; Female; Fever; H | 1994 |
Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Animals; Brain; Brain Injuries; Brain Neoplasms; Brain Ste | 1998 |
Neuroleptic malignant syndrome induced by haloperidol following traumatic brain injury.
Topics: Adolescent; Amantadine; Brain Injuries; Dopamine Agents; Dopamine Antagonists; Fever; Haloperidol; H | 1999 |
Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; | 2001 |
Renin dependency of blood-pressure. Analysis by angiotensin II antagonist P113 in hypertensive patients treated with salt depletion and propranolol.
Topics: Adolescent; Adult; Angiotensin II; Antihypertensive Agents; Blood Pressure; Brain Injuries; Diet, So | 1976 |
Propranolol for severe post-head injury action tremor.
Topics: Brain Injuries; Child; Humans; Male; Movement; Propranolol; Tremor | 1978 |
Propranolol for the control of belligerent behavior following acute brain damage.
Topics: Adult; Aggression; Brain Concussion; Brain Injuries; Cerebrovascular Disorders; Humans; Male; Middle | 1977 |
Cardiovascular responses to autonomic blockade in brain-injured fetal lambs.
Topics: Animals; Atropine; Autonomic Nerve Block; Blood Pressure; Brain; Brain Injuries; Carotid Arteries; G | 1978 |
Neurogenic hyperacute ascites in mice.
Topics: Acute Disease; Adrenergic beta-Agonists; Animals; Ascitic Fluid; Brain Injuries; Male; Methoxamine; | 1986 |
[Guide lines for the treatment of patients with the apallic and postopallic syndrome].
Topics: Amino Acids; Brain Diseases; Brain Injuries; Cachexia; Cerebral Cortex; Contracture; Diet Therapy; D | 1973 |
[Effect of beta adrenergic blocking agents on the changes of the ST segment and T wave observed in patients with brain-stem damage].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Brain Injuries; Brain Neoplasms; Brain Ste | 1972 |
The effects of brain stem compression on the heart.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bradycardia; Brain Injuries; Brain Stem; Ca | 1974 |
On the mechanism of the pressor response due to propranolol.
Topics: Animals; Blood Pressure; Brain Injuries; Bretylium Compounds; Heart Rate; Hexamethonium Compounds; I | 1968 |