propranolol and Acathisia, Drug-Induced studies

Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.

Research Excerpts

Excerpt	Relevance	Reference
"We present two cases of acute nocturnal bruxism occurring as an early side effect of antipsychotic drug treatment."	5.30	Bruxism secondary to antipsychotic drug exposure: a positive response to propranolol. ( Amir, I; Gavish, A; Hermesh, H, 1997)
"Suicidal ideation was significantly associated with clinician observed akathisia, depressed mood, younger age, and use of propranolol."	2.77	Akathisia and suicidal ideation in first-episode schizophrenia. ( Gaebel, W; Gastpar, M; Heuser, I; Jäger, M; Klingenberg, S; Klosterkötter, J; Lewitzka, U; Maier, W; Mayr, A; Möller, HJ; Musil, R; Ohmann, C; Riedel, M; Schennach, R; Schlösser, R; Schmitt, A; Schneider, F; Seemüller, F, 2012)
"Zolmitriptan is a selective 5-HT(1D) agonist."	2.74	Zolmitriptan compared to propranolol in the treatment of acute neuroleptic-induced akathisia: a comparative double-blind study. ( Avital, A; Gross-Isseroff, R; Hermesh, H; Shiloh, R; Stryjer, R; Weizman, A, 2009)
"Antipsychotic-induced akathisia is optimally managed by reducing the medication dose or switching to a second generation antipsychotic that is less prone to inducing akathisia."	2.72	Struggling to find Effective Pharmacologic Options for Akathisia? B-CALM! ( Birur, B; Fargason, RE; Thippaiah, SM, 2021)
"Propranolol failed to produce a significant improvement overall in any of the akathisia measures, with only one patient showing clinical improvement."	2.67	Intravenous benztropine and propranolol challenges in acute neuroleptic-induced akathisia. ( Loneragan, C; Sachdev, P, 1993)
"Surprisingly, the evidence for its anti-akathisia effect is modest."	2.66	Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT ( Poyurovsky, M; Weizman, A, 2020)
"Mirtazapine was better tolerated than propranolol."	1.35	Role of mirtazapine in the treatment of antipsychotic-induced akathisia. ( Dellenbaugh, T; Hieber, R; Nelson, LA, 2008)
"We present two cases of acute nocturnal bruxism occurring as an early side effect of antipsychotic drug treatment."	1.30	Bruxism secondary to antipsychotic drug exposure: a positive response to propranolol. ( Amir, I; Gavish, A; Hermesh, H, 1997)
"Haloperidol-treated rats had higher bolus counts than vehicle-treated rats, and this increase was significantly reversed by the lipophilic but not the hydrophilic beta-antagonists."	1.30	The effects of beta-adrenoceptor antagonists on a rat model of neuroleptic-induced akathisia. ( Sachdev, PS; Saharov, T, 1997)
"Akathisia improved in 4 patients with idiopathic Parkinson's disease after low dose propranolol treatment."	1.28	Studies on the time course and efficacy of beta-blockers in neuroleptic-induced akathisia and the akathisia of idiopathic Parkinson's disease. ( Adler, LA; Angrist, B; Rotrosen, J; Weinreb, H, 1991)
"All three patients developed severe akathisia during retreatment with fluoxetine and stated that the development of the akathisia made them feel suicidal and that it had precipitated their prior suicide attempts."	1.28	Reexposure to fluoxetine after serious suicide attempts by three patients: the role of akathisia. ( Locke, CA; Rothschild, AJ, 1991)
"Metoprolol was compared to propranolol in the treatment of neuroleptic-induced akathisia by means of an on-drug/off-drug crossover study."	1.27	Comparison of metoprolol and propranolol in the treatment of akathisia. ( Barreira, PJ; Cohen, BM; Lipinski, JF; Zubenko, GS, 1984)
"Propranolol was found to be an effective treatment of tardive akathisia in both patients."	1.27	Propranolol in the treatment of tardive akathisia: a report of two cases. ( Iskandar, H; Nastase, C; Yassa, R, 1988)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (43.14)	18.7374
1990's	20 (39.22)	18.2507
2000's	5 (9.80)	29.6817
2010's	2 (3.92)	24.3611
2020's	2 (3.92)	2.80

Authors	Studies
Poyurovsky, M	2
Weizman, A	4
Thippaiah, SM	1
Fargason, RE	1
Birur, B	1
Deng, S	1
Hu, J	1
Zhu, X	1
Shang, D	1
Wen, Y	1
Qiu, C	1
Avital, A	1
Gross-Isseroff, R	1
Stryjer, R	1
Hermesh, H	5
Shiloh, R	1
Seemüller, F	1
Schennach, R	1
Mayr, A	1
Musil, R	1
Jäger, M	1
Maier, W	1
Klingenberg, S	1
Heuser, I	1
Klosterkötter, J	1
Gastpar, M	1
Schmitt, A	1
Schlösser, R	1
Schneider, F	1
Ohmann, C	1
Lewitzka, U	1
Gaebel, W	1
Möller, HJ	1
Riedel, M	1
Pashinian, A	1
Weizman, R	1
Fuchs, C	1
Sahoo, S	1
Ameen, S	1
Hieber, R	1
Dellenbaugh, T	1
Nelson, LA	1
Kulik, AV	1
Wilbur, R	1
Lipinski, JF	4
Zubenko, GS	2
Cohen, BM	2
Barreira, PJ	2
Ratey, JJ	1
Salzman, C	1
Adler, LA	8
Angrist, BM	1
Sachdev, P	3
Loneragan, C	2
Remington, G	1
Fornazzari, L	1
Sethna, R	1
Sabaawi, M	1
Richmond, DR	1
Fragala, MR	1
Peselow, E	4
Rosenthal, M	1
Angrist, B	13
Auzou, P	1
Ozsancak, C	1
Hannequin, D	1
Augustin, P	1
Botschev, C	1
Bondy, B	1
Hofmann, M	1
Kircher, T	1
Müller-Spahn, F	1
Eberstein, S	1
Amir, I	1
Gavish, A	1
Kurzthaler, I	1
Hummer, M	1
Kohl, C	1
Miller, C	1
Fleischhacker, WW	2
Sachdev, PS	1
Saharov, T	1
Manor, I	1
Munitz, H	3
Fischel, T	1
Aizenberg, D	1
Zemishlany, Z	1
Benjamini, Y	1
Dumon, JP	2
Catteau, J	2
Lanvin, F	1
Dupuis, BA	1
Fritz, P	1
Rotrosen, J	11
Mallya, G	1
Weinreb, H	1
Rothschild, AJ	1
Locke, CA	1
Chee, KY	1
Adler, L	6
Duncan, E	1
Hemdal, P	1
Slotnick, V	1
Kim, A	1
Kramer, MS	2
Gorkin, R	1
DiJohnson, C	2
Corwin, J	5
Keepers, GA	1
Casey, DE	1
Maslansky, R	1
Dupuis, B	1
Libert, C	1
Petit, H	1
Reiter, S	3
Herndal, P	1
Molcho, A	1
Yassa, R	1
Iskandar, H	1
Nastase, C	1
Irwin, M	1
Sullivan, G	1
Van Putten, T	1
Gorkin, RA	1
Sheves, P	1
Wang, HL	1
Keck, PE	1
McElroy, SL	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Maintenance Treatment vs. Stepwise Drug Discontinuation After One Year of Maintenance Treatment in First-Episode Schizophrenia[NCT00159120]			Phase 4	71 participants (Anticipated)	Interventional	2001-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT Drugs, 2020, Volume: 80, Issue:9 Topics: Akathisia, Drug-Induced; Algorithms; Antipsychotic Agents; Humans; Propranolol; Psychomotor Agitatio	2020
Struggling to find Effective Pharmacologic Options for Akathisia? B-CALM! Psychopharmacology bulletin, 2021, 06-01, Volume: 51, Issue:3 Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Humans; Mirtazapine; Propranolol; Psychomotor Agitati	2021
Clinical management of acute neuroleptic-induced extrapyramidal syndromes. Current psychiatric therapies, 1986, Volume: 23 Topics: Acute Disease; Adolescent; Adult; Age Factors; Akathisia, Drug-Induced; Amantadine; Antipsychotic Ag	1986
Beta-adrenergic antagonists in psychosis: is improvement due to treatment of neuroleptic-induced akathisia? Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:6 Topics: Adrenergic beta-Agonists; Akathisia, Drug-Induced; Antipsychotic Agents; Clinical Trials as Topic; D	1988

Article	Year
Zolmitriptan compared to propranolol in the treatment of acute neuroleptic-induced akathisia: a comparative double-blind study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2009, Volume: 19, Issue:7 Topics: Adrenergic beta-Antagonists; Adult; Akathisia, Drug-Induced; Anticonvulsants; Blood Pressure; Double	2009
Akathisia and suicidal ideation in first-episode schizophrenia. Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:5 Topics: Adult; Age Factors; Akathisia, Drug-Induced; Antipsychotic Agents; Depression; Double-Blind Method;	2012
Low-dose mirtazapine: a new option in the treatment of antipsychotic-induced akathisia. A randomized, double-blind, placebo- and propranolol-controlled trial. Biological psychiatry, 2006, Jun-01, Volume: 59, Issue:11 Topics: Adult; Akathisia, Drug-Induced; Analysis of Variance; Anti-Anxiety Agents; Antidepressive Agents, Tr	2006
Intravenous benztropine and propranolol challenges in tardive akathisia. Psychopharmacology, 1993, Volume: 113, Issue:1 Topics: Adult; Akathisia, Drug-Induced; Anxiety; Benztropine; Cross-Over Studies; Double-Blind Method; Dyski	1993
Placebo response in refractory tardive akathisia. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:4 Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Diazepam; Double-Blind Method; Humans; Male; Middle A	1993
Intravenous benztropine and propranolol challenges in acute neuroleptic-induced akathisia. Clinical neuropharmacology, 1993, Volume: 16, Issue:4 Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Benztropine; Double-Blind Metho	1993
A controlled comparison of the effects of propranolol, benztropine, and placebo on akathisia: an interim analysis. Psychopharmacology bulletin, 1993, Volume: 29, Issue:2 Topics: Adult; Aged; Akathisia, Drug-Induced; Benztropine; Humans; Middle Aged; Propranolol; Single-Blind Me	1993
Cyproheptadine versus propranolol for the treatment of acute neuroleptic-induced akathisia: a comparative double-blind study. Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Akathisia, Drug-Induced; Analysis of Variance; Antipsychotic Age	2001
Randomized, double-blind, crossover, placebo-controlled comparison of propranolol and betaxolol in the treatment of neuroleptic-induced akathisia. The American journal of psychiatry, 1992, Volume: 149, Issue:5 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Betaxolol; Double-Blind Method; Humans; Middle	1992
Lack of efficacy of d-propranolol in neuroleptic-induced akathisia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1991, Volume: 4, Issue:2 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Blood Pressure; Double-Blind Method; Female; H	1991
Pharmacological characterization of tardive akathisia. Biological psychiatry, 1990, Nov-01, Volume: 28, Issue:9 Topics: Administration, Oral; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Arousal; Atenolol; Benztr	1990
Effects of a specific beta 2-receptor blocker in neuroleptic-induced akathisia. Psychiatry research, 1989, Volume: 27, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Chronic Disease;	1989
Treatment of neuroleptic-induced akathisia with propranolol: a controlled replication study. The Hillside journal of clinical psychiatry, 1989, Volume: 11, Issue:2 Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Benztropine; Dose-Response Relationship, Drug; Double	1989
Efficacy of propranolol in neuroleptic-induced akathesia. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:3 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Chronic Disease; Female; Humans; Lorazepam; Ma	1985
A controlled assessment of propranolol in the treatment of neuroleptic-induced akathisia. The British journal of psychiatry : the journal of mental science, 1986, Volume: 149 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Clinical Trials as Topic; Double-Blind Method;	1986
Comparison of propranolol, sotalol, and betaxolol in the treatment of neuroleptic-induced akathisia. The American journal of psychiatry, 1987, Volume: 144, Issue:6 Topics: Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Betaxolol; Clinical Trials as Topic; Dos	1987
Noradrenergic mechanisms in akathisia: treatment with propranolol and clonidine. Psychopharmacology bulletin, 1987, Volume: 23, Issue:1 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Clonidine; Female; Humans; Male; Middle Aged;	1987
Atenolol and propranolol in neuroleptic-induced akathisia. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:4 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Atenolol; Female; Humans; Male; Middle Aged; P	1987
Propranolol as a primary treatment of neuroleptic-induced akathisia. The Hillside journal of clinical psychiatry, 1988, Volume: 10, Issue:2 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Clinical Trials as Topic; Double-Blind Method;	1988
Propranolol in the treatment of neuroleptic-induced akathisia (NIA) in schizophrenics: a double-blind, placebo-controlled study. Biological psychiatry, 1988, Volume: 24, Issue:7 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Arousal; Double-Blind Method; Humans; Male; Mi	1988
Beta-adrenergic antagonists in psychosis: is improvement due to treatment of neuroleptic-induced akathisia? Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:6 Topics: Adrenergic beta-Agonists; Akathisia, Drug-Induced; Antipsychotic Agents; Clinical Trials as Topic; D	1988

propranolol and Acathisia, Drug-Induced

Research Excerpts

Research

Studies (51)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Sleepwalking Is Associated With Coadministration of Olanzapine and Propranolol: A Case Report. Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:5 Topics: Adrenergic beta-Antagonists; Akathisia, Drug-Induced; Antipsychotic Agents; Drug Therapy, Combinatio	2017
Acute nocturnal akathisia induced by clozapine. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2 Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Ci	2007
Role of mirtazapine in the treatment of antipsychotic-induced akathisia. The Annals of pharmacotherapy, 2008, Volume: 42, Issue:6 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Akathisia, Drug-Induced; Antipsychotic Ag	2008
Case report of propranolol (Inderal) pharmacotherapy for neuroleptic-induced akathisia and tremor. Progress in neuro-psychopharmacology & biological psychiatry, 1983, Volume: 7, Issue:2-3 Topics: Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Drug Therapy, Combination; Dyskinesia, Drug-Ind	1983
Propranolol in the treatment of neuroleptic-induced akathisia. The American journal of psychiatry, 1984, Volume: 141, Issue:3 Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Female; Humans;	1984
Comparison of metoprolol and propranolol in the treatment of akathisia. Psychiatry research, 1984, Volume: 11, Issue:2 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Blood	1984
Recognizing and managing akathisia. Hospital & community psychiatry, 1984, Volume: 35, Issue:10 Topics: Adrenergic beta-Antagonists; Akathisia, Drug-Induced; Anti-Anxiety Agents; Antipsychotic Agents; Ben	1984
Paroxetine and akathisia. Biological psychiatry, 1995, Mar-01, Volume: 37, Issue:5 Topics: Akathisia, Drug-Induced; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug; Drug Adm	1995
Akathisia in association with nortriptyline therapy. American family physician, 1993, Nov-01, Volume: 48, Issue:6 Topics: Adult; Aged; Akathisia, Drug-Induced; Female; Humans; Male; Nortriptyline; Propranolol	1993
[Akathisia induced by low doses of neuroleptics after a pallidal infarction]. Presse medicale (Paris, France : 1983), 1996, Feb-17, Volume: 25, Issue:6 Topics: Aged; Akathisia, Drug-Induced; Anti-Anxiety Agents; Antipsychotic Agents; Cerebral Infarction; Femal	1996
Beta 2-receptor density on mononuclear blood cells in patients suffering from neuroleptic-induced akathisia (NIA). Biological psychiatry, 1996, Aug-01, Volume: 40, Issue:3 Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Female; Humans; Male; Middle	1996
Nefazodone and akathisia. Biological psychiatry, 1996, Oct-15, Volume: 40, Issue:8 Topics: Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Clonazepam; Depressive Disorder;	1996
Bruxism secondary to antipsychotic drug exposure: a positive response to propranolol. Clinical neuropharmacology, 1997, Volume: 20, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bruxism; Female;	1997
Propranolol treatment of olanzapine-induced akathisia. The American journal of psychiatry, 1997, Volume: 154, Issue:9 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Benzodiazepines; Drug Administration Schedule;	1997
The effects of beta-adrenoceptor antagonists on a rat model of neuroleptic-induced akathisia. Psychiatry research, 1997, Sep-19, Volume: 72, Issue:2 Topics: Adrenergic beta-Antagonists; Akathisia, Drug-Induced; Animals; Antipsychotic Agents; Arousal; Catale	1997
Propranolol: a treatment for pseudoakathisia. The Journal of nervous and mental disease, 1994, Volume: 182, Issue:4 Topics: Adult; Agnosia; Akathisia, Drug-Induced; Haloperidol; Humans; Male; Middle Aged; Perphenazine; Propr	1994
Studies on the time course and efficacy of beta-blockers in neuroleptic-induced akathisia and the akathisia of idiopathic Parkinson's disease. Psychopharmacology bulletin, 1991, Volume: 27, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Female; Hum	1991
Efficacy of betaxolol in neuroleptic-induced akathisia. Psychiatry research, 1991, Volume: 39, Issue:2 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Betaxolol; Drug Administration Schedule; Human	1991
Reexposure to fluoxetine after serious suicide attempts by three patients: the role of akathisia. The Journal of clinical psychiatry, 1991, Volume: 52, Issue:12 Topics: Adult; Akathisia, Drug-Induced; Depressive Disorder; Drug Therapy, Combination; Female; Fluoxetine;	1991
Propanolol for fluoxetine-induced akathisia. Biological psychiatry, 1991, Sep-01, Volume: 30, Issue:5 Topics: Akathisia, Drug-Induced; Depressive Disorder; Female; Fluoxetine; Humans; Middle Aged; Neurologic Ex	1991
Efficacy of low-dose metoprolol in neuroleptic-induced akathisia. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:4 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Chronic Disease; Dose-Response Relationship, D	1989
Pindolol and propranolol in neuroleptic-induced akathisia. The American journal of psychiatry, 1987, Volume: 144, Issue:9 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Humans; Middle Aged; Pindolol; Propranolol; Ps	1987
Neuroleptic-induced akathisia: propranolol versus benztropine. Biological psychiatry, 1988, Jan-15, Volume: 23, Issue:2 Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Benztropine; Humans; Propranolol; Psychomotor Agitati	1988
Beta blockers in neuroleptic-induced akathisia. The American journal of psychiatry, 1988, Volume: 145, Issue:7 Topics: Adrenergic beta-Antagonists; Akathisia, Drug-Induced; Antipsychotic Agents; Humans; Propranolol; Psy	1988
Successful propranolol therapy for neuroleptic-induced akathisia resistant to anticholinergic and benzodiazepine drugs. Clinical neuropharmacology, 1988, Volume: 11, Issue:4 Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Diazepam; Female; Humans; Male; Propranolol; P	1988
Propranolol in the treatment of tardive akathisia: a report of two cases. Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:4 Topics: Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Female; Humans; Propranolol; Psychomotor Agitat	1988
[Propranolol in the treatment of neuroleptic-induced akathisia]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1988, Volume: 21, Issue:5 Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Female; Humans; Male; Propranolol;	1988