propofol has been researched along with Torsade de Pointes in 10 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is conflicting evidence regarding the impact of propofol on cardiac repolarization and the risk of torsade de pointes (TdP)." | 7.96 | Propofol abolishes torsade de pointes in different models of acquired long QT syndrome. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Könemann, H; Rath, B; Reinke, F; Wegner, FK; Willy, K; Wolfes, J, 2020) |
| "We report the case of a 70-year-old man presenting with the development of torsade de pointes (TDP) during infusion of propofol in the setting of severe hypoalbuminemia." | 7.76 | QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia. ( Irie, T; Kaneko, Y; Kurabayashi, M; Nakajima, T; Saito, A, 2010) |
| "We present a case of congenital long QT syndrome which developed torsade de pointes during sevoflurane anesthesia for implantation of an internal cardioverter-defibrillator." | 7.73 | Torsade de pointes during sevoflurane anesthesia in a child with congenital long QT syndrome. ( Davy, JM; Frapier, JM; Massad, I; Raczka, F; Saussine, M, 2006) |
| "There is conflicting evidence regarding the impact of propofol on cardiac repolarization and the risk of torsade de pointes (TdP)." | 3.96 | Propofol abolishes torsade de pointes in different models of acquired long QT syndrome. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Könemann, H; Rath, B; Reinke, F; Wegner, FK; Willy, K; Wolfes, J, 2020) |
| "We report the case of a 70-year-old man presenting with the development of torsade de pointes (TDP) during infusion of propofol in the setting of severe hypoalbuminemia." | 3.76 | QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia. ( Irie, T; Kaneko, Y; Kurabayashi, M; Nakajima, T; Saito, A, 2010) |
| "We present a case of congenital long QT syndrome which developed torsade de pointes during sevoflurane anesthesia for implantation of an internal cardioverter-defibrillator." | 3.73 | Torsade de pointes during sevoflurane anesthesia in a child with congenital long QT syndrome. ( Davy, JM; Frapier, JM; Massad, I; Raczka, F; Saussine, M, 2006) |
| "Propofol has no effect on myocardial repolarization in healthy children at clinically relevant doses." | 2.73 | The effect of propofol concentration on dispersion of myocardial repolarization in children. ( Chau, A; Hume-Smith, HV; Lim, J; Sanatani, S; Whyte, SD, 2008) |
| "Propofol is a sedative-anesthetic with proarrhythmic effects on cardiac myocytes." | 1.46 | The possible role of propofol in drug-induced torsades de pointes: A real-world single-center analysis. ( Abrich, VA; Mehta, A; Mookadam, F; Ramakrishna, H; Srivathsan, K, 2017) |
| "We describe a patient who developed torsade de pointes followed by ventricular fibrillation while undergoing propofol sedation for closed reduction of a mid-shaft fracture of the tibia and fibula." | 1.35 | Cardiac arrhythmia during propofol sedation. ( Cadogan, M; Douglas, RJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ellermann, C | 1 |
| Könemann, H | 1 |
| Wolfes, J | 1 |
| Rath, B | 1 |
| Wegner, FK | 1 |
| Willy, K | 1 |
| Dechering, DG | 1 |
| Reinke, F | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Abrich, VA | 1 |
| Ramakrishna, H | 1 |
| Mehta, A | 1 |
| Mookadam, F | 1 |
| Srivathsan, K | 1 |
| Hume-Smith, HV | 1 |
| Sanatani, S | 1 |
| Lim, J | 1 |
| Chau, A | 1 |
| Whyte, SD | 1 |
| Douglas, RJ | 1 |
| Cadogan, M | 1 |
| Goudie, AM | 1 |
| Patterson, H | 1 |
| Brown, SG | 1 |
| Irie, T | 1 |
| Kaneko, Y | 1 |
| Nakajima, T | 1 |
| Saito, A | 1 |
| Kurabayashi, M | 1 |
| Saussine, M | 1 |
| Massad, I | 1 |
| Raczka, F | 1 |
| Davy, JM | 1 |
| Frapier, JM | 1 |
| Kaplanian, S | 1 |
| Chambers, NA | 1 |
| Vincze, D | 1 |
| Farkas, AS | 1 |
| Rudas, L | 1 |
| Makra, P | 1 |
| Csík, N | 1 |
| Leprán, I | 1 |
| Forster, T | 1 |
| Csanády, M | 1 |
| Papp, JG | 1 |
| Varró, A | 1 |
| Farkas, A | 1 |
| Kuenszberg, E | 1 |
| Loeckinger, A | 1 |
| Kleinsasser, A | 1 |
| Lindner, KH | 1 |
| Puehringer, F | 1 |
| Hoermann, C | 1 |
2 trials available for propofol and Torsade de Pointes
| Article | Year |
|---|---|
The effect of propofol concentration on dispersion of myocardial repolarization in children.
Topics: Anesthesia; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Drug Int | 2008 |
Sevoflurane progressively prolongs the QT interval in unpremedicated female adults.
Topics: Adult; Analysis of Variance; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Elec | 2000 |
8 other studies available for propofol and Torsade de Pointes
| Article | Year |
|---|---|
Propofol abolishes torsade de pointes in different models of acquired long QT syndrome.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrocardiography; Erythromycin; Heart; Heart | 2020 |
The possible role of propofol in drug-induced torsades de pointes: A real-world single-center analysis.
Topics: Aged; Electrocardiography; Female; Follow-Up Studies; Forecasting; Heart Conduction System; Heart Ra | 2017 |
Cardiac arrhythmia during propofol sedation.
Topics: Aged; Conscious Sedation; Emergency Medicine; Female; Humans; Hypnotics and Sedatives; Propofol; Tor | 2008 |
Cardiac arrhythmia or movement artefact?
Topics: Artifacts; Conscious Sedation; Electrocardiography; Humans; Hypnotics and Sedatives; Muscular Diseas | 2009 |
QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia.
Topics: Aged; Comorbidity; Electrocardiography; Endocarditis; Heart Conduction System; Humans; Hypnotics and | 2010 |
Torsade de pointes during sevoflurane anesthesia in a child with congenital long QT syndrome.
Topics: Anesthetics, Inhalation; Anticonvulsants; Child; Defibrillators, Implantable; Electrocardiography; H | 2006 |
Anesthesia in a child with newly diagnosed Hypertrophic Cardiomyopathy.
Topics: Anesthesia; Anesthetics, Intravenous; Cardiomyopathy, Hypertrophic; Child, Preschool; Defibrillators | 2006 |
Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits.
Topics: Anesthesia; Anesthetics; Animals; Anti-Inflammatory Agents; Baroreflex; Blood Pressure; Chloralose; | 2008 |