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propofol and Syndrome

propofol has been researched along with Syndrome in 112 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Syndrome: A characteristic symptom complex.

Research Excerpts

ExcerptRelevanceReference
"To assess the effect of paravertebral administration of dexmedetomidine as an adjuvant to local anesthetic on the intraoperative anesthetic drug requirement and incidence of post-thoracotomy pain syndrome."9.24Effect of Continuous Paravertebral Dexmedetomidine Administration on Intraoperative Anesthetic Drug Requirement and Post-Thoracotomy Pain Syndrome After Thoracotomy: A Randomized Controlled Trial. ( Dutta, V; Jayant, A; Kumar, B; Mishra, AK, 2017)
"To investigate biochemically whether total intravenous anesthesia (TIVA) using propofol creates a risk for Propofol Infusion Syndrome (PRIS)."9.17Biochemical markers in total intravenous anesthesia and propofol infusion syndrome: a preliminary study. ( Gürses, E; Oztürk, I; Serin, S, 2013)
" Compared to earlier case reports in the literature, recently published cases describe older patients developing PRIS at lower doses of propofol, in whom arrhythmia, hypertriglyceridaemia and fever are less frequently seen, with survival more likely."8.91Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. ( Anděl, M; Duška, F; Krajčová, A; Waldauf, P, 2015)
" Keywords were propofol, propofol infusion syndrome (PRIS), rhabdomyolysis, heart failure, arrhythmias, metabolic acidosis, brain injury, sedation, intensive care."8.86[Propofol infusion syndrome]. ( Greff, B; Laquay, N; Meyer, P; Orliaguet, G; Prieur, S, 2010)
"Propofol infusion syndrome (PRIS) is defined as acute bradycardia progressing to asystole combined with lipemic plasma, fatty liver enlargement, metabolic acidosis with negative base excess >10 mmol l(-1), rhabdomyolysis or myoglobinuria associated with propofol infusion."8.85Propofol infusion syndrome: update of clinical manifestation and pathophysiology. ( Bein, B; Fudickar, A, 2009)
"A case of propofol infusion syndrome in a patient with respiratory failure and sepsis is reported."8.85Propofol infusion syndrome: case report and literature review. ( Chen, J; Cohen, N; Nadkarni, A; Orsini, J, 2009)
"The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol."8.84Propofol infusion syndrome. ( Cardone, D; Kam, PC, 2007)
"The propofol infusion syndrome is a rare condition characterized by the occurrence of lactic acidosis, rhabdomyolysis and cardiovascular collapse following high-dose propofol infusion over prolonged periods of time."8.84Update on the propofol infusion syndrome in ICU management of patients with head injury. ( Cremer, OL; Kalkman, CJ; Otterspoor, LC, 2008)
"AstraZeneca (the manufacturer of Diprivan) presents its review of the history of the so-called 'propofol infusion syndrome', highlighting the difficulties in analysing the incomplete information available."8.83The 'propofol infusion syndrome': the facts, their interpretation and implications for patient care. ( Ahlen, K; Buckley, CJ; Goodale, DB; Pulsford, AH, 2006)
"Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactacidosis, lipaemic plasma and cardiac failure, associated with propofol infusion over prolonged periods of time."8.83Propofol infusion syndrome in anaesthesia and intensive care medicine. ( Bein, B; Fudickar, A; Tonner, PH, 2006)
"Propofol infusion syndrome (PRIS) is a rare and often fatal syndrome described in critically ill children undergoing long-term propofol infusion at high doses."8.82The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. ( Candiani, A; Latronico, N; Rasulo, F; Vasile, B, 2003)
"Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h."8.82[Propofol infusion syndrome]. ( Motsch, J; Roggenbach, J, 2004)
"Propofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality."7.81Therapeutic plasma exchange as treatment for propofol infusion syndrome. ( Levin, PD; Levin, V; Rund, D; Sprung, CL; Weissman, C, 2015)
"Propofol infusion syndrome (PIS) is defined by arrhythmia, rhabdomyolysis, lactic acidosis, and unrecognized leads to death."7.80Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol. ( Clement, LP; Croce, MA; Fabian, TC; Fischer, PE; Lee, M; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP, 2014)
"To address the issue of propofol-related infusion syndrome and its management."7.79Propofol-related infusion syndrome: role of propofol in medical complications of sedated critical care patients. ( Imam, TH, 2013)
"Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol."7.78Propofol infusion syndrome heralded by ECG changes. ( Aslan, A; Jacobs, B; Mijzen, EJ; Rodgers, MG, 2012)
"A case of PRIS is described in a 17-year-old female with refractory status epilepticus (RSE) who was receiving high-dose propofol for seizure control and sedation."7.77Propofol Infusion syndrome during refractory status epilepticus in a young adult: successful ECMO resuscitation. ( Al Habash, O; Boutoille, D; Bretonniere, C; Derkinderen, P; Gabillet, L; Guitton, C; Latour, P; Rigal, JC; Villers, D, 2011)
"Propofol infusion syndrome (PRIS) is a rare but frequently fatal condition."7.77Lactate-to-pyruvate ratio as a marker of propofol infusion syndrome after subarachnoid hemorrhage. ( Kumar, MA; Levine, JM; Pisapia, JM; Wendell, LC; Zager, EL, 2011)
"Here we describe a case of propofol-related infusion syndrome (PRIS) in a child with malignant refractory status epilepticus treated with partial-exchange blood transfusion (PEBT), an innovative method of resuscitation that has the potential to reduce the mortality rate associated with this syndrome."7.76Partial-exchange blood transfusion: an effective method for preventing mortality in a child with propofol infusion syndrome. ( Asuncion, A; Coquillon, P; Da-Silva, SS; Gavrilita, C; Wong, R, 2010)
"Propofol is a sedative, anesthetic, and antiepileptic agent that is frequently used in patients with refractory status epilepticus."7.75Propofol infusion syndrome in patients with refractory status epilepticus: an 11-year clinical experience. ( Hoel, R; Iyer, VN; Rabinstein, AA, 2009)
"The propofol infusion syndrome is a potentially devastating cardiovascular and metabolic derangement that has been described in both pediatric and adult patients sedated with propofol."7.75The propofol infusion syndrome: more puzzling evidence on a complex and poorly characterized disorder. ( Cremer, OL, 2009)
" Future controlled studies focusing on evaluating whether propofol manifests the derangements of critical illness more frequently than other sedatives will need to be large."7.75Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study. ( Anger, KE; Arpino, PA; Barletta, JF; Devlin, JW; Fong, JJ; Gerlach, AT; Grgurich, P; Kendall, E; Kuper, PJ; Papadopoulos, S; Roberts, RJ; Ruthazer, R; Schumaker, G; Szumita, PM; Voils, SA; Xamplas, R; Yogaratnam, D, 2009)
" After exclusion of potential causes for this phenomenon, it was attributed to perioperative intravenous propofol infusion causing propofol infusion syndrome."7.75Propofol infusion syndrome in adult cardiac surgery. ( Balacumaraswami, L; Ilyas, MI; Palin, C; Ratnatunga, C, 2009)
"To identify predictors of mortality in patients with suspected propofol infusion syndrome and to develop a simple scoring system to identify patients with suspected propofol infusion syndrome who are most at risk of death."7.74Predictors of mortality in patients with suspected propofol infusion syndrome. ( Devlin, JW; Fong, JJ; Kcomt, M; Ruthazer, R; Schumaker, G; Sylvia, L, 2008)
"Antimuscarinic syndrome (AS), a rare but serious adverse event associated with propofol should be included in the differential diagnosis of patients who develop agitation after its administration."7.74Antimuscarinic syndrome after propofol administration in the emergency department. ( Clements, EA; Eppert, AJ; Judge, BS; Snow, KA, 2007)
"Propofol is increasingly used for the treatment of status epilepticus due to the ease of use and tolerability, even if safety data from randomized clinical trials are lacking."7.74Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus. ( Harris, BT; Jobst, BC; Zarovnaya, EL, 2007)
"The authors report a case of short-term high-dose propofol-related metabolic acidosis in a 3-year-old girl."7.74Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. ( Muhonen, MG; Nwagwu, CI; Westhout, FD, 2007)
"The occurrence of metabolic acidosis, rhabdomyolysis, hyperkalemia, and sudden cardiac death after long-term, high-dose propofol infusion has been referred to as propofol infusion syndrome (PRIS)."7.73Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. ( Antzelevitch, C; Brugada, R; Cremer, OL; Crijns, HJ; Delhaas, T; Di Diego, JM; Kalkman, CJ; Oliva, A; Prinzen, FW; Rodriguez, LM; Timmermans, C; Vernooy, K; Volders, PG, 2006)
"Propofol infusion syndrome is described in the pediatric literature as metabolic acidosis, rhabdomyolysis, and bradycardia that results in death."7.73The syndrome of irreversible acidosis after prolonged propofol infusion. ( Abou-Khaled, KJ; Kumar, MA; Schwartzman, RJ; Thomas, CE; Urrutia, VC, 2005)
"The propofol infusion syndrome is a rare but potentially lethal complication resulting from a prolonged continuous administration of propofol."7.73[Propofol infusion syndrome]. ( Jost, R; Likar, R; Oher, M; Pointner, I; Schalk, HV; Trampitsch, E, 2006)
"Propofol infusion syndrome has been increasingly recognized as a syndrome of unexplained myocardial failure, metabolic acidosis, and rhabdomyolysis with renal failure."7.72Propofol infusion syndrome: an unusual cause of renal failure. ( Casserly, B; Eisele, G; Haqqie, S; O'Mahony, E; Timm, EG; Urizar, R, 2004)
"Propofol is used for the treatment of refractory status epilepticus."7.72Fatal propofol infusion syndrome in association with ketogenic diet. ( Baumeister, FA; Eberhardt, J; Holthausen, H; Kunkel, J; Liebhaber, GM; Oberhoffer, R; Peters, J, 2004)
"This report describes a fatal case of the propofol infusion syndrome in an adult patient being sedated for a closed head injury using high doses of propofol."7.72Propofol infusion syndrome--report of an adult fatality. ( Ernest, D; French, C, 2003)
"Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children given long-term propofol infusions."7.71Impaired fatty acid oxidation in propofol infusion syndrome. ( Segar, P; Shield, J; Stone, J; Weir, P; Wolf, A, 2001)
"The author presents a case report where, following propofol sedation for a peribulbar block, sneezing was induced once the local anaesthetic needle was placed in the orbital cavity."7.69Sudden unexpected sneezing during the insertion of peribulbar block under propofol sedation. ( Abramson, DC, 1995)
"Propofol is a short-acting intravenous anesthetic agent widely used for sedation in anesthesia and intensive care."6.44The propofol infusion 'syndrome' in intensive care unit: from pathophysiology to prophylaxis and treatment. ( Dragoumanis, C; Papaioannou, V; Pneumatikos, I; Theodorou, V, 2008)
"Propofol has gained popularity for its rapid onset and rapid recovery even after prolonged use, and for the neuroprotection conferred."6.44Propofol infusion syndrome: an overview of a perplexing disease. ( Fodale, V; La Monaca, E, 2008)
"During this period 44 children with respiratory tract infections had been admitted to this unit and sedated for at least 48 h."6.40Propofol infusion syndrome in children. ( Bray, RJ, 1998)
"Propofol was utilized as part of the anesthetic protocol."5.48Propofol infusion-like syndrome in a dog. ( Mallard, JM; Peterson, NW; Rieser, TM, 2018)
"Propofol is a short-acting intravenous anesthetic agent."5.42Possible pathogenic mechanism of propofol infusion syndrome involves coenzyme q. ( Dacremont, G; de Jaeger, A; De Latter, E; De Paepe, B; De Paepe, P; Jorens, PG; Okun, JG; Smet, J; Van Coster, R; Van Regenmortel, N; Vanheel, B; Vanlander, AV; Wuyts, B, 2015)
"Propofol is an anesthetic agent widely used for induction and maintenance of anesthesia, and sedation in children."5.38Inborn oxidative phosphorylation defect as risk factor for propofol infusion syndrome. ( De Paepe, B; Jorens, PG; Lissens, W; Meire, F; Okun, JG; Pauwels, P; Seneca, S; Smet, J; Van Coster, R; Van den Eynden, GG; Van der Aa, N; Vanlander, AV; Verbrugghe, W, 2012)
"Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children who are given prolonged high-dose infusions of the drug."5.34Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury. ( Coritsidis, G; Rehman, Z; Sabsovich, I; Yunen, J, 2007)
"She developed multiple organ failure with rhabdomyolysis and died."5.33A case of suspected non-neurosurgical adult fatal propofol infusion syndrome. ( Eriksen, J; Povey, HM, 2006)
"Propofol was administered at the dose of 3-5 mg."5.31[A case of hyperperfusion syndrome treated successfully by propofol]. ( Horinouchi, T; Kato, M; Sato, K; Shimizu, H, 2001)
"To assess the effect of paravertebral administration of dexmedetomidine as an adjuvant to local anesthetic on the intraoperative anesthetic drug requirement and incidence of post-thoracotomy pain syndrome."5.24Effect of Continuous Paravertebral Dexmedetomidine Administration on Intraoperative Anesthetic Drug Requirement and Post-Thoracotomy Pain Syndrome After Thoracotomy: A Randomized Controlled Trial. ( Dutta, V; Jayant, A; Kumar, B; Mishra, AK, 2017)
"To investigate biochemically whether total intravenous anesthesia (TIVA) using propofol creates a risk for Propofol Infusion Syndrome (PRIS)."5.17Biochemical markers in total intravenous anesthesia and propofol infusion syndrome: a preliminary study. ( Gürses, E; Oztürk, I; Serin, S, 2013)
" Compared to earlier case reports in the literature, recently published cases describe older patients developing PRIS at lower doses of propofol, in whom arrhythmia, hypertriglyceridaemia and fever are less frequently seen, with survival more likely."4.91Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. ( Anděl, M; Duška, F; Krajčová, A; Waldauf, P, 2015)
" Keywords were propofol, propofol infusion syndrome (PRIS), rhabdomyolysis, heart failure, arrhythmias, metabolic acidosis, brain injury, sedation, intensive care."4.86[Propofol infusion syndrome]. ( Greff, B; Laquay, N; Meyer, P; Orliaguet, G; Prieur, S, 2010)
"A case of propofol infusion syndrome in a patient with respiratory failure and sepsis is reported."4.85Propofol infusion syndrome: case report and literature review. ( Chen, J; Cohen, N; Nadkarni, A; Orsini, J, 2009)
"Propofol infusion syndrome (PRIS) is defined as acute bradycardia progressing to asystole combined with lipemic plasma, fatty liver enlargement, metabolic acidosis with negative base excess >10 mmol l(-1), rhabdomyolysis or myoglobinuria associated with propofol infusion."4.85Propofol infusion syndrome: update of clinical manifestation and pathophysiology. ( Bein, B; Fudickar, A, 2009)
"The propofol infusion syndrome is a rare condition characterized by the occurrence of lactic acidosis, rhabdomyolysis and cardiovascular collapse following high-dose propofol infusion over prolonged periods of time."4.84Update on the propofol infusion syndrome in ICU management of patients with head injury. ( Cremer, OL; Kalkman, CJ; Otterspoor, LC, 2008)
"The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol."4.84Propofol infusion syndrome. ( Cardone, D; Kam, PC, 2007)
"Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactacidosis, lipaemic plasma and cardiac failure, associated with propofol infusion over prolonged periods of time."4.83Propofol infusion syndrome in anaesthesia and intensive care medicine. ( Bein, B; Fudickar, A; Tonner, PH, 2006)
"AstraZeneca (the manufacturer of Diprivan) presents its review of the history of the so-called 'propofol infusion syndrome', highlighting the difficulties in analysing the incomplete information available."4.83The 'propofol infusion syndrome': the facts, their interpretation and implications for patient care. ( Ahlen, K; Buckley, CJ; Goodale, DB; Pulsford, AH, 2006)
"Propofol infusion syndrome (PRIS) is a rare and often fatal syndrome described in critically ill children undergoing long-term propofol infusion at high doses."4.82The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. ( Candiani, A; Latronico, N; Rasulo, F; Vasile, B, 2003)
"Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h."4.82[Propofol infusion syndrome]. ( Motsch, J; Roggenbach, J, 2004)
" In the first operation, in which anesthesia induction was applied with ketamine and midazolam, extremity movements with surgical stimuli were seen."3.85Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case. ( Arslan, M; Balaban, A; Duman, Y; Gisi, G; Oksuz, G; Oksuz, H; Urfalioglu, A; Yildiz, H, 2017)
"Propofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality."3.81Therapeutic plasma exchange as treatment for propofol infusion syndrome. ( Levin, PD; Levin, V; Rund, D; Sprung, CL; Weissman, C, 2015)
"Propofol infusion syndrome (PIS) is defined by arrhythmia, rhabdomyolysis, lactic acidosis, and unrecognized leads to death."3.80Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol. ( Clement, LP; Croce, MA; Fabian, TC; Fischer, PE; Lee, M; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP, 2014)
"To address the issue of propofol-related infusion syndrome and its management."3.79Propofol-related infusion syndrome: role of propofol in medical complications of sedated critical care patients. ( Imam, TH, 2013)
"Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol."3.78Propofol infusion syndrome heralded by ECG changes. ( Aslan, A; Jacobs, B; Mijzen, EJ; Rodgers, MG, 2012)
"A case of PRIS is described in a 17-year-old female with refractory status epilepticus (RSE) who was receiving high-dose propofol for seizure control and sedation."3.77Propofol Infusion syndrome during refractory status epilepticus in a young adult: successful ECMO resuscitation. ( Al Habash, O; Boutoille, D; Bretonniere, C; Derkinderen, P; Gabillet, L; Guitton, C; Latour, P; Rigal, JC; Villers, D, 2011)
"Propofol infusion syndrome (PRIS) is a rare but frequently fatal condition."3.77Lactate-to-pyruvate ratio as a marker of propofol infusion syndrome after subarachnoid hemorrhage. ( Kumar, MA; Levine, JM; Pisapia, JM; Wendell, LC; Zager, EL, 2011)
"Here we describe a case of propofol-related infusion syndrome (PRIS) in a child with malignant refractory status epilepticus treated with partial-exchange blood transfusion (PEBT), an innovative method of resuscitation that has the potential to reduce the mortality rate associated with this syndrome."3.76Partial-exchange blood transfusion: an effective method for preventing mortality in a child with propofol infusion syndrome. ( Asuncion, A; Coquillon, P; Da-Silva, SS; Gavrilita, C; Wong, R, 2010)
" We report a case of safe perioperative management with general anesthesia, using total intravenous anesthesia, propofol, fentanyl and a non-depolarizing muscle relaxant but avoiding the use of any inhaled anesthetics or depolarizing muscle relaxants to prevent malignant hyperthermia and postoperative respiratory failure, during anesthetic management for cranioplasty for premature synostosis of the cranial sutures in a pediatric patient of CNMDU1."3.76Anesthetic case in a child with congenital neuromuscular disease with uniform type 1 fibers (CNMDU1). ( Arashi, D; Okutani, R; Tsujii, K, 2010)
"The propofol infusion syndrome is a potentially devastating cardiovascular and metabolic derangement that has been described in both pediatric and adult patients sedated with propofol."3.75The propofol infusion syndrome: more puzzling evidence on a complex and poorly characterized disorder. ( Cremer, OL, 2009)
" Future controlled studies focusing on evaluating whether propofol manifests the derangements of critical illness more frequently than other sedatives will need to be large."3.75Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study. ( Anger, KE; Arpino, PA; Barletta, JF; Devlin, JW; Fong, JJ; Gerlach, AT; Grgurich, P; Kendall, E; Kuper, PJ; Papadopoulos, S; Roberts, RJ; Ruthazer, R; Schumaker, G; Szumita, PM; Voils, SA; Xamplas, R; Yogaratnam, D, 2009)
"Propofol is a sedative, anesthetic, and antiepileptic agent that is frequently used in patients with refractory status epilepticus."3.75Propofol infusion syndrome in patients with refractory status epilepticus: an 11-year clinical experience. ( Hoel, R; Iyer, VN; Rabinstein, AA, 2009)
" After exclusion of potential causes for this phenomenon, it was attributed to perioperative intravenous propofol infusion causing propofol infusion syndrome."3.75Propofol infusion syndrome in adult cardiac surgery. ( Balacumaraswami, L; Ilyas, MI; Palin, C; Ratnatunga, C, 2009)
"To identify predictors of mortality in patients with suspected propofol infusion syndrome and to develop a simple scoring system to identify patients with suspected propofol infusion syndrome who are most at risk of death."3.74Predictors of mortality in patients with suspected propofol infusion syndrome. ( Devlin, JW; Fong, JJ; Kcomt, M; Ruthazer, R; Schumaker, G; Sylvia, L, 2008)
"Propofol is increasingly used for the treatment of status epilepticus due to the ease of use and tolerability, even if safety data from randomized clinical trials are lacking."3.74Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus. ( Harris, BT; Jobst, BC; Zarovnaya, EL, 2007)
"The authors report a case of short-term high-dose propofol-related metabolic acidosis in a 3-year-old girl."3.74Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. ( Muhonen, MG; Nwagwu, CI; Westhout, FD, 2007)
"Antimuscarinic syndrome (AS), a rare but serious adverse event associated with propofol should be included in the differential diagnosis of patients who develop agitation after its administration."3.74Antimuscarinic syndrome after propofol administration in the emergency department. ( Clements, EA; Eppert, AJ; Judge, BS; Snow, KA, 2007)
"Propofol infusion syndrome is described in the pediatric literature as metabolic acidosis, rhabdomyolysis, and bradycardia that results in death."3.73The syndrome of irreversible acidosis after prolonged propofol infusion. ( Abou-Khaled, KJ; Kumar, MA; Schwartzman, RJ; Thomas, CE; Urrutia, VC, 2005)
"The occurrence of metabolic acidosis, rhabdomyolysis, hyperkalemia, and sudden cardiac death after long-term, high-dose propofol infusion has been referred to as propofol infusion syndrome (PRIS)."3.73Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. ( Antzelevitch, C; Brugada, R; Cremer, OL; Crijns, HJ; Delhaas, T; Di Diego, JM; Kalkman, CJ; Oliva, A; Prinzen, FW; Rodriguez, LM; Timmermans, C; Vernooy, K; Volders, PG, 2006)
"The propofol infusion syndrome is a rare but potentially lethal complication resulting from a prolonged continuous administration of propofol."3.73[Propofol infusion syndrome]. ( Jost, R; Likar, R; Oher, M; Pointner, I; Schalk, HV; Trampitsch, E, 2006)
"Propofol infusion syndrome has been increasingly recognized as a syndrome of unexplained myocardial failure, metabolic acidosis, and rhabdomyolysis with renal failure."3.72Propofol infusion syndrome: an unusual cause of renal failure. ( Casserly, B; Eisele, G; Haqqie, S; O'Mahony, E; Timm, EG; Urizar, R, 2004)
"Propofol is used for the treatment of refractory status epilepticus."3.72Fatal propofol infusion syndrome in association with ketogenic diet. ( Baumeister, FA; Eberhardt, J; Holthausen, H; Kunkel, J; Liebhaber, GM; Oberhoffer, R; Peters, J, 2004)
"We review the anesthetic implications of Joubert syndrome and report that spinal anesthesia under intravenous propofol sedation proved satisfactory for repair of an inguinal hernia in a spontaneously ventilating infant with this syndrome."3.72Anesthetic management in Joubert syndrome. ( Gordon, GJ; Vodopich, DJ, 2004)
"This case report discusses the cause of death in a 3-year-old child who survived a high dose (20 mg x kg-1 x h-1) of propofol, infused over a period of 15 h, following which the patient developed a combined respiratory and metabolic acidosis, the oxygenation remaining normal."3.72Death after re-exposure to propofol in a 3-year-old child: a case report. ( Aring, C; Gillor, A; Holzki, J, 2004)
"This report describes a fatal case of the propofol infusion syndrome in an adult patient being sedated for a closed head injury using high doses of propofol."3.72Propofol infusion syndrome--report of an adult fatality. ( Ernest, D; French, C, 2003)
"Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children given long-term propofol infusions."3.71Impaired fatty acid oxidation in propofol infusion syndrome. ( Segar, P; Shield, J; Stone, J; Weir, P; Wolf, A, 2001)
"The author presents a case report where, following propofol sedation for a peribulbar block, sneezing was induced once the local anaesthetic needle was placed in the orbital cavity."3.69Sudden unexpected sneezing during the insertion of peribulbar block under propofol sedation. ( Abramson, DC, 1995)
"Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness."2.47Clinical effects and lethal and forensic aspects of propofol. ( Levy, RJ, 2011)
"Propofol has gained popularity for its rapid onset and rapid recovery even after prolonged use, and for the neuroprotection conferred."2.44Propofol infusion syndrome: an overview of a perplexing disease. ( Fodale, V; La Monaca, E, 2008)
"Propofol is a short-acting intravenous anesthetic agent widely used for sedation in anesthesia and intensive care."2.44The propofol infusion 'syndrome' in intensive care unit: from pathophysiology to prophylaxis and treatment. ( Dragoumanis, C; Papaioannou, V; Pneumatikos, I; Theodorou, V, 2008)
"During this period 44 children with respiratory tract infections had been admitted to this unit and sedated for at least 48 h."2.40Propofol infusion syndrome in children. ( Bray, RJ, 1998)
"Propofol was utilized as part of the anesthetic protocol."1.48Propofol infusion-like syndrome in a dog. ( Mallard, JM; Peterson, NW; Rieser, TM, 2018)
"Propofol is a short-acting intravenous anesthetic agent."1.42Possible pathogenic mechanism of propofol infusion syndrome involves coenzyme q. ( Dacremont, G; de Jaeger, A; De Latter, E; De Paepe, B; De Paepe, P; Jorens, PG; Okun, JG; Smet, J; Van Coster, R; Van Regenmortel, N; Vanheel, B; Vanlander, AV; Wuyts, B, 2015)
"Propofol is an anesthetic agent widely used for induction and maintenance of anesthesia, and sedation in children."1.38Inborn oxidative phosphorylation defect as risk factor for propofol infusion syndrome. ( De Paepe, B; Jorens, PG; Lissens, W; Meire, F; Okun, JG; Pauwels, P; Seneca, S; Smet, J; Van Coster, R; Van den Eynden, GG; Van der Aa, N; Vanlander, AV; Verbrugghe, W, 2012)
"Freeman-Sheldon syndrome, or distal arthrogryposis type 2A, is a rare congenital myopathy and dysplasia characterised by multiple contractures, abnormalities of the head and face, defective development of the hands and feet and skeletal malformations."1.35Anaesthetic management of a child with Freeman-sheldon syndrome undergoing spinal surgery. ( Richa, FC; Yazbeck, PH, 2008)
"Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children who are given prolonged high-dose infusions of the drug."1.34Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury. ( Coritsidis, G; Rehman, Z; Sabsovich, I; Yunen, J, 2007)
"She developed multiple organ failure with rhabdomyolysis and died."1.33A case of suspected non-neurosurgical adult fatal propofol infusion syndrome. ( Eriksen, J; Povey, HM, 2006)
"This syndrome is relatively uncommon and accompanies dyspnea and hypoxemia on changing to a sitting or standing from recumbent position."1.32[Anesthetic management for a patient with platypnea-orthodeoxia syndrome]. ( Kawamoto, K; Terasaki, H; Yoshitake, A, 2004)
"Propofol was stopped."1.32A case of propofol toxicity: further evidence for a causal mechanism. ( Al Ayed, T; Decell, MK; Withington, DE, 2004)
"Sotos syndrome is a rare condition characterized by typical facies, early accelerated growth, large body size, developmental delay and congenital heart defects."1.32Anaesthesia in a child with Sotos syndrome. ( Adhami, EJ; Cancio-Babu, CV, 2003)
"Propofol was administered at the dose of 3-5 mg."1.31[A case of hyperperfusion syndrome treated successfully by propofol]. ( Horinouchi, T; Kato, M; Sato, K; Shimizu, H, 2001)

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (7.14)18.2507
2000's73 (65.18)29.6817
2010's31 (27.68)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Urfalioglu, A1
Arslan, M1
Duman, Y1
Gisi, G1
Oksuz, G1
Yildiz, H1
Oksuz, H1
Balaban, A1
Choi, SR1
Kim, JH1
Chae, KL1
Lee, SC1
Park, SY1
Mallard, JM1
Rieser, TM1
Peterson, NW1
Imam, TH1
Schroeppel, TJ1
Fabian, TC1
Clement, LP1
Fischer, PE1
Magnotti, LJ1
Sharpe, JP1
Lee, M1
Croce, MA1
Savard, M1
Dupré, N1
Turgeon, AF1
Desbiens, R1
Langevin, S1
Brunet, D1
Oztürk, I1
Serin, S1
Gürses, E1
Poretti, A1
Bosemani, T1
Huisman, TA1
Vanlander, AV2
Okun, JG2
de Jaeger, A1
Smet, J2
De Latter, E1
De Paepe, B2
Dacremont, G1
Wuyts, B1
Vanheel, B1
De Paepe, P1
Jorens, PG2
Van Regenmortel, N1
Van Coster, R2
Chen, L1
Lim, FA1
Levin, PD1
Levin, V1
Weissman, C1
Sprung, CL1
Rund, D1
Krajčová, A1
Waldauf, P1
Anděl, M1
Duška, F1
Honore, PM1
Spapen, HD1
Dutta, V1
Kumar, B1
Jayant, A1
Mishra, AK1
Zaccheo, MM1
Bucher, DH1
Papaioannou, V1
Dragoumanis, C1
Theodorou, V1
Pneumatikos, I1
Fong, JJ2
Sylvia, L1
Ruthazer, R2
Schumaker, G2
Kcomt, M1
Devlin, JW3
Otterspoor, LC1
Kalkman, CJ2
Cremer, OL3
Bader, MK1
Vislosky, M1
Bebarta, VS2
Summers, S2
Pavlov, OO1
Laquay, N2
Pouard, P1
Silicani, MA1
Vaccaroni, L1
Orliaguet, G2
Ilyas, MI1
Balacumaraswami, L1
Palin, C1
Ratnatunga, C1
Blossom, DB1
Chen, TH1
Li, J1
Langer, AJ1
Carpenter, LR1
Glenshaw, MT1
Gould, CV1
Weltman, A1
Srinivasan, A1
Fudickar, A3
Bein, B3
Orsini, J1
Nadkarni, A1
Chen, J2
Cohen, N1
Iyer, VN1
Hoel, R1
Rabinstein, AA1
Blum, JM1
Brunsvold, ME1
Roberts, RJ1
Barletta, JF1
Kuper, PJ1
Papadopoulos, S1
Yogaratnam, D1
Kendall, E1
Xamplas, R1
Gerlach, AT1
Szumita, PM1
Anger, KE1
Arpino, PA1
Voils, SA1
Grgurich, P1
Riker, RR2
Glisic, EK1
Fraser, GL1
Shoemaker, JD1
Prieur, S1
Greff, B1
Meyer, P1
Schneemilch, C1
Da-Silva, SS1
Wong, R1
Coquillon, P1
Gavrilita, C1
Asuncion, A1
Guitton, C1
Gabillet, L1
Latour, P1
Rigal, JC1
Boutoille, D1
Al Habash, O1
Derkinderen, P1
Bretonniere, C1
Villers, D1
Mallow-Corbett, S1
Okutani, R1
Arashi, D1
Tsujii, K1
Levy, RJ1
Fernández, AB1
Fernández, J1
Pisapia, JM1
Wendell, LC1
Kumar, MA2
Zager, EL1
Levine, JM1
Amrein, S1
Amrein, K1
Amegah-Sakotnik, A1
Reist, U1
Ensner, R1
Faulkner, MJ1
Haley, MW1
Littmann, L1
Pickard, A1
Verbrugghe, W1
Van den Eynden, GG1
Meire, F1
Pauwels, P1
Van der Aa, N1
Seneca, S1
Lissens, W1
Testerman, GM1
Chow, TT1
Easparam, S1
Annecke, T1
Conzen, P1
Ney, L1
Mijzen, EJ1
Jacobs, B1
Aslan, A1
Rodgers, MG1
Crawford, MW1
Dodgson, BG1
Holtby, HH1
Roy, WL1
Sloan, IA1
Pulsford, AH2
Ernest, D1
French, C1
Vasile, B1
Rasulo, F1
Candiani, A1
Latronico, N1
Lirk, P1
Rieder, J1
Schuerholz, A1
Keller, C1
Adhami, EJ1
Cancio-Babu, CV1
Koch, M1
De Backer, D1
Vincent, JL1
Holzki, J1
Aring, C1
Gillor, A1
Kawamoto, K1
Yoshitake, A1
Terasaki, H1
Wolf, AR1
Potter, F1
Withington, DE1
Decell, MK1
Al Ayed, T1
Baumeister, FA1
Oberhoffer, R1
Liebhaber, GM1
Kunkel, J1
Eberhardt, J1
Holthausen, H1
Peters, J1
Vodopich, DJ1
Gordon, GJ1
Motsch, J1
Roggenbach, J1
Casserly, B1
O'Mahony, E1
Timm, EG1
Haqqie, S1
Eisele, G1
Urizar, R1
Machata, AM1
Gonano, C1
Bîrsan, T1
Zimpfer, M1
Spiss, CK1
Uezono, S1
Hotta, Y1
Takakuwa, Y1
Ozaki, M1
Colomb, S1
Gonzalez, D1
Dissait, F1
Urrutia, VC1
Thomas, CE1
Abou-Khaled, KJ1
Schwartzman, RJ1
Wessel, N1
Schirdewan, A1
Vernooy, K1
Delhaas, T1
Di Diego, JM1
Oliva, A1
Timmermans, C1
Volders, PG1
Prinzen, FW1
Crijns, HJ1
Antzelevitch, C1
Rodriguez, LM1
Brugada, R1
Eriksen, J1
Povey, HM1
Salengros, JC1
Engelman, E1
Hermanns, H1
Lipfert, P1
Ladda, S1
Stevens, MF1
Tonner, PH2
Cohen, S1
Hunter, CW1
Yanni, B1
Striker, P1
Hijazi, RH1
Ahlen, K1
Buckley, CJ1
Goodale, DB1
Trampitsch, E1
Oher, M1
Pointner, I1
Likar, R1
Jost, R1
Schalk, HV1
Platis, CM1
Wasersprung, D1
Kachko, L1
Tsunzer, I1
Katz, J1
De Waele, JJ1
Hoste, E1
Wysowski, DK1
Pollock, ML1
Crozier, TA1
Sabsovich, I1
Rehman, Z1
Yunen, J1
Coritsidis, G1
Guibert Bayona, MA1
Borque Martín, JL1
Araújo Fernández, AM1
Ruiz Ilundáin, G1
Westhout, FD1
Muhonen, MG1
Nwagwu, CI1
Zarovnaya, EL1
Jobst, BC1
Harris, BT1
Karakitsos, D1
Poularas, J1
Kalogeromitros, A1
Karabinis, A1
Lynch, G1
Clinton, S1
Siotia, A1
Kam, PC1
Cardone, D1
Snow, KA1
Clements, EA1
Eppert, AJ1
Judge, BS1
Rosen, DJ1
Nicoara, A1
Koshy, N1
Wedderburn, RV1
Rozet, I1
Lam, AM1
Corbett, SM1
Montoya, ID1
Moore, FA1
Hill, M1
Peat, W1
Courtman, S1
Knab, J1
Heupel, EW1
Steinmann, D1
Richa, FC1
Yazbeck, PH1
Fodale, V1
La Monaca, E1
Bhakta, P1
Goel, A1
Acharjee, P1
Biswas, BK1
Mihaljovic, Z1
Dellien, C1
Weiler, N1
Scholz, J1
Abramson, DC1
Borges, M1
Antognini, JF1
Bray, RJ2
Susla, GM1
Hatch, DJ1
Jorgensen, BG1
Laub, M1
Knudsen, RH1
Hashiguchi, K1
O'Higashi, T1
Sasai, S1
Kiguchi, T1
Uga, H1
Matsuura, H1
Sato, K1
Shimizu, H1
Horinouchi, T1
Kato, M1
Wolf, A1
Weir, P1
Segar, P1
Stone, J1
Shield, J1
Myburgh, JA1
Upton, RN1
Abrahams, JM1
Reiter, GT1
Acker, MA1
Sinson, GP1
Friedman, JA1
Manno, E1
Fulgham, JR1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894]124 participants (Actual)Observational2016-09-07Completed
Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)[NCT04358835]0 participants (Actual)Interventional2020-09-01Withdrawn (stopped due to Study did not begin enrollment, multiple competing studies at same institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

21 reviews available for propofol and Syndrome

ArticleYear
Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports.
    Critical care (London, England), 2015, Nov-12, Volume: 19

    Topics: Anesthetics, Intravenous; Arrhythmias, Cardiac; Fever; Heart Failure; Hepatomegaly; Humans; Hypertri

2015
Propofol infusion syndrome: a rare complication with potentially fatal results.
    Critical care nurse, 2008, Volume: 28, Issue:3

    Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Critical Care;

2008
The propofol infusion 'syndrome' in intensive care unit: from pathophysiology to prophylaxis and treatment.
    Acta anaesthesiologica Belgica, 2008, Volume: 59, Issue:2

    Topics: Acidosis; Adult; Anesthetics, Intravenous; Cardiovascular Diseases; Child; Heart; Humans; Hyperkalem

2008
Update on the propofol infusion syndrome in ICU management of patients with head injury.
    Current opinion in anaesthesiology, 2008, Volume: 21, Issue:5

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Brain Injuries; Critical Care; Dose-Response Rela

2008
Propofol infusion syndrome: update of clinical manifestation and pathophysiology.
    Minerva anestesiologica, 2009, Volume: 75, Issue:5

    Topics: Acidosis; Acute Disease; Adult; Age Factors; Anesthetics, Intravenous; Animals; Bradycardia; Brain I

2009
Propofol infusion syndrome: case report and literature review.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2009, May-15, Volume: 66, Issue:10

    Topics: Adult; Anesthetics, Intravenous; Drug Administration Schedule; Exanthema; Female; Hepatomegaly; Huma

2009
[Propofol infusion syndrome].
    Annales francaises d'anesthesie et de reanimation, 2010, Volume: 29, Issue:5

    Topics: Acidosis; Arrhythmias, Cardiac; Heart Failure; Humans; Hypnotics and Sedatives; Infusions, Intraveno

2010
Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive care unit.
    Critical care medicine, 2010, Volume: 38, Issue:6 Suppl

    Topics: Acidosis; Analgesics; Antipsychotic Agents; Bradycardia; Cardiovascular Diseases; Critical Care; Dru

2010
Clinical effects and lethal and forensic aspects of propofol.
    Journal of forensic sciences, 2011, Volume: 56 Suppl 1

    Topics: Accidents; Acidosis; Acute Kidney Injury; Bacteremia; Bradycardia; Drug Overdose; Dyslipidemias; For

2011
The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome.
    Intensive care medicine, 2003, Volume: 29, Issue:9

    Topics: Adult; Animals; Catecholamines; Central Nervous System; Critical Illness; Drug Interactions; Drug Th

2003
[Propofol infusion syndrome].
    Der Anaesthesist, 2004, Volume: 53, Issue:10

    Topics: Acid-Base Imbalance; Acidosis, Lactic; Anesthesia, Intravenous; Anesthetics, Intravenous; Chemistry,

2004
Propofol infusion syndrome in anaesthesia and intensive care medicine.
    Current opinion in anaesthesiology, 2006, Volume: 19, Issue:4

    Topics: Acidosis; Anesthesia; Anesthetics, Intravenous; Critical Care; Heart Failure; Humans; Hyperlipidemia

2006
The 'propofol infusion syndrome': the facts, their interpretation and implications for patient care.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:12

    Topics: Adolescent; Adult; Anesthesia; Anesthetics, Intravenous; Child; Child, Preschool; Critical Care; Dia

2006
Reports of death with use of propofol (Diprivan) for nonprocedural (long-term) sedation and literature review.
    Anesthesiology, 2006, Volume: 105, Issue:5

    Topics: Acidosis; Adult; Adverse Drug Reaction Reporting Systems; Cardiovascular System; Child; Humans; Hypn

2006
Propofol infusion syndrome.
    Anaesthesia, 2007, Volume: 62, Issue:7

    Topics: Acidosis; Adolescent; Adult; Anesthetics, Intravenous; Biomarkers; Bradycardia; Child; Child, Presch

2007
Too much of a good thing? Tracing the history of the propofol infusion syndrome.
    The Journal of trauma, 2007, Volume: 63, Issue:2

    Topics: Accidents, Traffic; Acute Kidney Injury; Adolescent; Adult; Anuria; Brain Injuries; Critical Care; D

2007
Propofol-related infusion syndrome in intensive care patients.
    Pharmacotherapy, 2008, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Hypnotics and Sedatives; Infant; Infusio

2008
Propofol infusion syndrome: an overview of a perplexing disease.
    Drug safety, 2008, Volume: 31, Issue:4

    Topics: Acidosis; Anesthetics, Intravenous; Arrhythmias, Cardiac; Heart Failure; Hepatomegaly; Humans; Hypno

2008
Propofol infusion syndrome in children.
    Paediatric anaesthesia, 1998, Volume: 8, Issue:6

    Topics: Acidosis; Child; Child, Preschool; Female; Heart Diseases; Humans; Hypnotics and Sedatives; Infant;

1998
Propofol toxicity in critically ill pediatric patients: show us the proof.
    Critical care medicine, 1998, Volume: 26, Issue:12

    Topics: Acidosis, Lactic; Anesthetics, Intravenous; Bradycardia; Child; Child, Preschool; Conscious Sedation

1998
Propofol-infusion syndrome in children.
    Lancet (London, England), 1999, Apr-03, Volume: 353, Issue:9159

    Topics: Adverse Drug Reaction Reporting Systems; Child; Critical Care; Hospital Mortality; Humans; Hypnotics

1999

Trials

3 trials available for propofol and Syndrome

ArticleYear
Biochemical markers in total intravenous anesthesia and propofol infusion syndrome: a preliminary study.
    European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:24

    Topics: Adult; Analysis of Variance; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenou

2013
Effect of Continuous Paravertebral Dexmedetomidine Administration on Intraoperative Anesthetic Drug Requirement and Post-Thoracotomy Pain Syndrome After Thoracotomy: A Randomized Controlled Trial.
    Journal of cardiothoracic and vascular anesthesia, 2017, Volume: 31, Issue:1

    Topics: Adjuvants, Anesthesia; Adult; Aged; Amides; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetic

2017
[The tissue oxygen cascade as the marker in different schemes of general anesthesia on dynamics of the hypoxic syndrome in patients, suffering an acute hemorrhage of high operative risk].
    Klinichna khirurhiia, 2008, Issue:6

    Topics: Acute Disease; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Female; Fen

2008

Other Studies

88 other studies available for propofol and Syndrome

ArticleYear
Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2017, Volume: 84, Issue:5

    Topics: Anesthesia; Body Temperature; Calcaneus; Child; Consciousness Monitors; Foot Ulcer; Hereditary Senso

2017
Anesthetic considerations during surgical intervention in Woake's syndrome -a case report.
    Korean journal of anesthesiology, 2019, Volume: 72, Issue:3

    Topics: Adolescent; Anesthesia, Intravenous; Anesthetics, Intravenous; Ethmoid Sinus; Humans; Infusions, Int

2019
Propofol infusion-like syndrome in a dog.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2018, Volume: 59, Issue:11

    Topics: Acidosis; Acute Kidney Injury; Animals; Arrhythmias, Cardiac; Dog Diseases; Dogs; Female; Hypnotics

2018
Propofol-related infusion syndrome: role of propofol in medical complications of sedated critical care patients.
    The Permanente journal, 2013,Spring, Volume: 17, Issue:2

    Topics: Arrhythmias, Cardiac; Fatal Outcome; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Male;

2013
Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol.
    Injury, 2014, Volume: 45, Issue:1

    Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cohort Studies

2014
Propofol-related infusion syndrome heralding a mitochondrial disease: case report.
    Neurology, 2013, Aug-20, Volume: 81, Issue:8

    Topics: Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Diagnosis, Differential; Fatal Outcome; Femal

2013
Neuroimaging findings in pediatric propofol infusion syndrome.
    Pediatric neurology, 2014, Volume: 50, Issue:4

    Topics: Anesthetics, Intravenous; Arteriovenous Malformations; Brain; Child, Preschool; Diffusion Magnetic R

2014
Possible pathogenic mechanism of propofol infusion syndrome involves coenzyme q.
    Anesthesiology, 2015, Volume: 122, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Citric Acid Cycle; Electron Transport; Male; Muscle, Skeletal; Pr

2015
Propofol infusion syndrome: a rare but lethal complication.
    Nursing, 2014, Volume: 44, Issue:12

    Topics: Anesthetics, Intravenous; Critical Care Nursing; Fatal Outcome; Humans; Infusions, Intravenous; Male

2014
Therapeutic plasma exchange as treatment for propofol infusion syndrome.
    Journal of clinical apheresis, 2015, Volume: 30, Issue:5

    Topics: Accidents, Traffic; Acidosis, Lactic; Acute Kidney Injury; Adolescent; Anticonvulsants; Biomarkers;

2015
Propofol infusion syndrome: early blood purification to the rescue?
    Critical care (London, England), 2016, 07-04, Volume: 20, Issue:1

    Topics: Anesthetics, Intravenous; Humans; Infusions, Intravenous; Propofol; Propofol Infusion Syndrome; Synd

2016
Predictors of mortality in patients with suspected propofol infusion syndrome.
    Critical care medicine, 2008, Volume: 36, Issue:8

    Topics: Adolescent; Anesthetics, Intravenous; Child; Female; Humans; Logistic Models; Male; Middle Aged; Mor

2008
Tier approach to propofol infusion syndrome.
    Critical care nurse, 2008, Volume: 28, Issue:5

    Topics: Anesthetics, Intravenous; Combined Modality Therapy; Critical Care; Drug Monitoring; Humans; Infusio

2008
Propofol-induced Brugada electrocardiographic pattern.
    Critical care nurse, 2008, Volume: 28, Issue:5

    Topics: Anesthetics, Intravenous; Brugada Syndrome; Critical Care; Drug Monitoring; Electrocardiography; Hum

2008
Early stages of propofol infusion syndrome in paediatric cardiac surgery: two cases in adolescent girls.
    British journal of anaesthesia, 2008, Volume: 101, Issue:6

    Topics: Acidosis, Lactic; Adolescent; Anesthetics, Intravenous; Child; Female; Humans; Hypnotics and Sedativ

2008
Propofol infusion syndrome in adult cardiac surgery.
    The Annals of thoracic surgery, 2009, Volume: 87, Issue:1

    Topics: Acidosis, Lactic; Aged; Anesthetics, Intravenous; Blood Chemical Analysis; Cardiopulmonary Bypass; C

2009
Self-limited febrile syndromes temporally associated with the use of propofol for sedation in gastrointestinal endoscopic procedures.
    Pharmacoepidemiology and drug safety, 2009, Volume: 18, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Chills; Drug Labeling; Endoscopy, Gastrointestinal; Fever;

2009
Predictor of mortality in suspected propofol infusion syndrome--Brugada electrocardiographic pattern.
    Critical care medicine, 2009, Volume: 37, Issue:2

    Topics: Anesthetics, Intravenous; Brugada Syndrome; Hospital Mortality; Humans; Predictive Value of Tests; P

2009
Propofol infusion syndrome in patients with refractory status epilepticus: an 11-year clinical experience.
    Critical care medicine, 2009, Volume: 37, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Critical Illness; Female; Human

2009
Non-acidotic propofol infusion syndrome.
    British journal of anaesthesia, 2009, Volume: 103, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Electrocardiography; Humans; Male; Propofol; Syndrome; Tachycardia,

2009
Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study.
    Critical care (London, England), 2009, Volume: 13, Issue:5

    Topics: Academic Medical Centers; Adult; Aged; Anesthetics, Intravenous; Arrhythmias, Cardiac; Critical Illn

2009
Propofol infusion syndrome: difficult to recognize, difficult to study.
    Critical care medicine, 2009, Volume: 37, Issue:12

    Topics: Critical Illness; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Propofol; Syndrome

2009
The propofol infusion syndrome: more puzzling evidence on a complex and poorly characterized disorder.
    Critical care (London, England), 2009, Volume: 13, Issue:6

    Topics: Adult; Child; Critical Illness; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Multicenter

2009
Diethylene glycol in propofol infusion syndrome?
    Drug safety, 2010, Jan-01, Volume: 33, Issue:1

    Topics: Acidosis; Anesthetics, Intravenous; Drug Contamination; Ethylene Glycols; Humans; Hypnotics and Seda

2010
[General anaesthesia for neurological diseases].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2010, Volume: 45, Issue:5

    Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Autonomic Nervous System; Br

2010
Partial-exchange blood transfusion: an effective method for preventing mortality in a child with propofol infusion syndrome.
    Pediatrics, 2010, Volume: 125, Issue:6

    Topics: Child, Preschool; Electroencephalography; Exchange Transfusion, Whole Blood; Humans; Hypnotics and S

2010
Propofol Infusion syndrome during refractory status epilepticus in a young adult: successful ECMO resuscitation.
    Neurocritical care, 2011, Volume: 15, Issue:1

    Topics: Adolescent; Extracorporeal Membrane Oxygenation; Female; Humans; Hypnotics and Sedatives; Infusions,

2011
Anesthetic case in a child with congenital neuromuscular disease with uniform type 1 fibers (CNMDU1).
    Journal of anesthesia, 2010, Volume: 24, Issue:5

    Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Fentanyl; Humans; Hypertensi

2010
Reversible lactic acidosis and electrocardiographic changes in a neurosurgical patient during propofol anesthesia.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:5

    Topics: Acidosis, Lactic; Anesthetics, Inhalation; Anesthetics, Intravenous; Arrhythmias, Cardiac; Electroca

2010
Lactate-to-pyruvate ratio as a marker of propofol infusion syndrome after subarachnoid hemorrhage.
    Neurocritical care, 2011, Volume: 15, Issue:1

    Topics: Adult; Biomarkers; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lactic Acid; Pro

2011
Propofol infusion syndrome--a critical incident report highlighting the danger of reexposure.
    Journal of neurosurgical anesthesiology, 2011, Volume: 23, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Head Injuries, Closed; Humans; Hypnotics and Sedatives; Hypotension; In

2011
Propofol infusion syndrome with severe and dynamic Brugada electrocardiogram but benign clinical outcome.
    Journal of cardiovascular electrophysiology, 2011, Volume: 22, Issue:7

    Topics: Brugada Syndrome; Electrocardiography, Ambulatory; Humans; Infusions, Intravenous; Male; Propofol; S

2011
Petty syndrome--implications for anesthesia.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:12

    Topics: Abnormalities, Multiple; Androstanols; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous

2011
Inborn oxidative phosphorylation defect as risk factor for propofol infusion syndrome.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Humans; Infusions, Intravenous; Male; Muscle, Skeletal; Optic Atrop

2012
Propofol infusion syndrome: an algorithm for prevention.
    The American surgeon, 2011, Volume: 77, Issue:12

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous;

2011
Propofol-related infusion syndrome induced by "moderate dosage" in a patient with severe head trauma.
    Journal of clinical anesthesia, 2012, Volume: 24, Issue:1

    Topics: Acidosis; Adult; Anesthetics, Intravenous; Craniocerebral Trauma; Dose-Response Relationship, Drug;

2012
Propofol infusion syndrome heralded by ECG changes.
    Neurocritical care, 2012, Volume: 17, Issue:2

    Topics: Acidosis; Brain Injuries; Electrocardiography; Humans; Hypnotics and Sedatives; Intracranial Hyperte

2012
Propofol syndrome in children.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2003, Mar-18, Volume: 168, Issue:6

    Topics: Acidosis; Age Factors; Anesthetics, Intravenous; Child; Conscious Sedation; Critical Illness; Hepato

2003
Propofol syndrome in children.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2003, Mar-18, Volume: 168, Issue:6

    Topics: Age Factors; Anesthetics, Intravenous; Child; Child, Preschool; Conscious Sedation; Contraindication

2003
Comment: propofol infusion syndrome in critically ill patients.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Child; Critical Illness; Humans; Injections, Intravenous; Propofol;

2003
Propofol infusion syndrome--report of an adult fatality.
    Anaesthesia and intensive care, 2003, Volume: 31, Issue:3

    Topics: Adult; Electrocardiography; Fatal Outcome; Head Injuries, Closed; Humans; Hypnotics and Sedatives; I

2003
Anaesthetic implications of Robinow syndrome.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:8

    Topics: Abnormalities, Multiple; Androstanols; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, In

2003
Anaesthesia in a child with Sotos syndrome.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:9

    Topics: Adjuvants, Anesthesia; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Atrop

2003
Lactic acidosis: an early marker of propofol infusion syndrome?
    Intensive care medicine, 2004, Volume: 30, Issue:3

    Topics: Acidosis, Lactic; Anesthetics, Intravenous; Child, Preschool; Female; Humans; Propofol; Syndrome

2004
Death after re-exposure to propofol in a 3-year-old child: a case report.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:3

    Topics: Acidosis; Child, Preschool; Drug Overdose; Fatal Outcome; Female; Humans; Hypnotics and Sedatives; P

2004
[Anesthetic management for a patient with platypnea-orthodeoxia syndrome].
    Masui. The Japanese journal of anesthesiology, 2004, Volume: 53, Issue:2

    Topics: Aged; Anesthesia, General; Dyspnea; Fentanyl; Heart Septal Defects, Atrial; Humans; Hypoxia; Male; M

2004
Propofol infusion in children: when does an anesthetic tool become an intensive care liability?
    Paediatric anaesthesia, 2004, Volume: 14, Issue:6

    Topics: Acetylcarnitine; Adult; Biomarkers; Child; Conscious Sedation; Critical Care; Fatty Acids; Humans; H

2004
A case of propofol toxicity: further evidence for a causal mechanism.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:6

    Topics: Acidosis; Acute Kidney Injury; Arrhythmias, Cardiac; Cleft Lip; Conscious Sedation; Humans; Hypnotic

2004
Fatal propofol infusion syndrome in association with ketogenic diet.
    Neuropediatrics, 2004, Volume: 35, Issue:4

    Topics: Acidosis; Anticonvulsants; Child; Diet Therapy; Fatal Outcome; Humans; Infusions, Parenteral; Male;

2004
Anesthetic management in Joubert syndrome.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:10

    Topics: Agenesis of Corpus Callosum; Anesthesia; Anesthesia, Caudal; Apnea; Ataxia; Brain; Corpus Callosum;

2004
Propofol infusion syndrome: an unusual cause of renal failure.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 44, Issue:6

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Craniocerebral Trauma; Female; Humans; Infusions,

2004
Rare but dangerous adverse effects of propofol and thiopental in intensive care.
    The Journal of trauma, 2005, Volume: 58, Issue:3

    Topics: Acidosis; Adult; Anesthetics, Intravenous; Coma; Conscious Sedation; Critical Care; Fatal Outcome; F

2005
Acquired carnitine deficiency: a clinical model for propofol infusion syndrome?
    Anesthesiology, 2005, Volume: 103, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Carnitine; Fatty Acids; Humans; Mitochondria; Oxidation-Reduction;

2005
[Anaesthesia for nuclear magnetic imaging in a child with DRESS syndrome].
    Annales francaises d'anesthesie et de reanimation, 2006, Volume: 25, Issue:2

    Topics: Anesthesia, General; Anesthetics, Intravenous; Child, Preschool; Drug Eruptions; Eosinophilia; Epile

2006
The syndrome of irreversible acidosis after prolonged propofol infusion.
    Neurocritical care, 2005, Volume: 3, Issue:3

    Topics: Acidosis; Adult; Anesthetics, Intravenous; Fatal Outcome; Female; Humans; Infusions, Intravenous; Ma

2005
Toward a prediction of sudden death in propofol-related infusion syndrome.
    Heart rhythm, 2006, Volume: 3, Issue:2

    Topics: Acidosis; Acute Kidney Injury; Death, Sudden, Cardiac; Electrocardiography; Humans; Hypnotics and Se

2006
Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome.
    Heart rhythm, 2006, Volume: 3, Issue:2

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Death, Sudden, Cardiac; Electrocardiography; Humans; Hypn

2006
A case of suspected non-neurosurgical adult fatal propofol infusion syndrome.
    Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:1

    Topics: Adolescent; Anesthetics, Intravenous; Fatal Outcome; Female; Humans; Hypnotics and Sedatives; Infusi

2006
Myoglobinemia and propofol infusion.
    Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:1

    Topics: Anesthetics, Intravenous; Humans; Myoglobin; Propofol; Rhabdomyolysis; Syndrome

2006
Propofol infusion syndrome during anaesthesia for scoliosis surgery in an adolescent with neonatal progeroid syndrome.
    Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:3

    Topics: Acidosis; Adolescent; Anesthetics, Intravenous; Arrhythmias, Cardiac; Female; Humans; Progeria; Prop

2006
Central anticholinergic syndrome strikes again.
    Journal of clinical anesthesia, 2006, Volume: 18, Issue:5

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, General; Anesthetics, Intravenous; Central Nervous System

2006
[Propofol infusion syndrome].
    Der Anaesthesist, 2006, Volume: 55, Issue:11

    Topics: Acidosis; Acute Kidney Injury; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Arrhythmias,

2006
Anesthesia management for the child with Sanjad-Sakati syndrome.
    Paediatric anaesthesia, 2006, Volume: 16, Issue:11

    Topics: Abnormalities, Multiple; Anesthesia, Dental; Anesthetics, Inhalation; Anesthetics, Intravenous; Anes

2006
Propofol infusion syndrome in a patient with sepsis.
    Anaesthesia and intensive care, 2006, Volume: 34, Issue:5

    Topics: Abdominal Abscess; Acidosis; Adult; Anesthetics, Intravenous; Drainage; Heart Failure; Humans; Hyper

2006
The 'propofol infusion syndrome': myth or menace?
    European journal of anaesthesiology, 2006, Volume: 23, Issue:12

    Topics: Acidosis; Anesthesia; Anesthetics, Intravenous; Critical Care; Diagnosis, Differential; Humans; Hypo

2006
Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2007, Volume: 16, Issue:1

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Anesthetics, Intravenous; Brain Injuries; Fatal Outcome;

2007
[Anesthesia in May-Hegglin anomaly].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:9

    Topics: Adenocarcinoma; Anesthesia, Intravenous; Anesthetics, Intravenous; Anticoagulants; Aprotinin; Bernar

2006
Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report.
    Journal of neurosurgery, 2007, Volume: 106, Issue:2 Suppl

    Topics: Acidosis; Anesthetics, Intravenous; Aneurysm; Balloon Occlusion; Cardiac Output, Low; Carotid Artery

2007
Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus.
    Epilepsia, 2007, Volume: 48, Issue:5

    Topics: Acidosis; Adult; Age Factors; Anticonvulsants; Cardiac Output, Low; Cardiomyopathies; Fatal Outcome;

2007
The propofol infusion syndrome treated with haemofiltration. Is there a time for genetic screening?
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:5

    Topics: Adult; Anesthesia, Intravenous; Craniocerebral Trauma; Female; Genetic Testing; Hemofiltration; Huma

2007
Anaesthesia and Alström's syndrome.
    Anaesthesia and intensive care, 2007, Volume: 35, Issue:2

    Topics: Adult; Anesthesia; Anesthetics, Intravenous; Atrial Fibrillation; Blindness; Deafness; Diabetes Mell

2007
Antimuscarinic syndrome after propofol administration in the emergency department.
    The Journal of emergency medicine, 2007, Volume: 33, Issue:1

    Topics: Adult; Diagnosis, Differential; Drug Interactions; Emergency Service, Hospital; Humans; Hypnotics an

2007
Propofol infusion syndrome or probable overinterpretation syndrome?
    Anesthesiology, 2008, Volume: 108, Issue:2

    Topics: Acidosis, Lactic; Anesthetics, Intravenous; Cohort Studies; Humans; Infusions, Intravenous; Propofol

2008
A national survey of propofol infusion use by paediatric anaesthetists in Great Britain and Ireland.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:6

    Topics: Anesthesiology; Anesthetics, Intravenous; Electroencephalography; Health Care Surveys; Humans; Infus

2008
Anesthesia for orthopedic surgery in Pallister-Killian syndrome.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:7

    Topics: Abnormalities, Multiple; Alfentanil; Androstanols; Anesthesia; Anesthesia, Epidural; Anesthetics, Co

2008
Anaesthetic management of a child with Freeman-sheldon syndrome undergoing spinal surgery.
    Anaesthesia and intensive care, 2008, Volume: 36, Issue:2

    Topics: Abnormalities, Multiple; Anesthesia, General; Anesthetics, Intravenous; Arthrogryposis; Blood Pressu

2008
Propofol for the management of glycine-mediated excitatory symptoms of TURP syndrome.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:5

    Topics: Aged; Akathisia, Drug-Induced; Glycine; Glycine Agents; Humans; Hyperammonemia; Hypnotics and Sedati

2008
Suggested beginning of propofol infusion syndrome in an adult patient without lactacidosis: a case report.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:9

    Topics: Acidosis, Lactic; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain Diseases; Creatine

2008
Sudden unexpected sneezing during the insertion of peribulbar block under propofol sedation.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:8

    Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; Genes, Dominant; Humans; Lidocaine

1995
Anaesthesia for Mauriac's syndrome.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:1

    Topics: Adolescent; Anesthesia, General; Corneal Transplantation; Diabetes Mellitus; Diabetes Mellitus, Type

1993
Propofol-infusion syndrome in children.
    Lancet (London, England), 1999, Jun-12, Volume: 353, Issue:9169

    Topics: Child; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Propofol; Syndrome

1999
Anaesthetic implications of rigid spine syndrome.
    Paediatric anaesthesia, 1999, Volume: 9, Issue:4

    Topics: Adolescent; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Contracture; Fem

1999
[Anesthetic management of a patient with Coffin-Lowry syndrome].
    Masui. The Japanese journal of anesthesiology, 1999, Volume: 48, Issue:9

    Topics: Abnormalities, Multiple; Adult; Anesthesia, General; Anesthetics, Intravenous; Craniofacial Abnormal

1999
[A case of hyperperfusion syndrome treated successfully by propofol].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:1

    Topics: Aged; Anesthesia, Intravenous; Carotid Stenosis; Cerebrovascular Circulation; Cerebrovascular Disord

2001
Impaired fatty acid oxidation in propofol infusion syndrome.
    Lancet (London, England), 2001, Feb-24, Volume: 357, Issue:9256

    Topics: Acidosis; Carnitine; Critical Care; Electron Transport; Fatty Acids; Hemofiltration; Humans; Hypnoti

2001
Propofol use in head-injury patients.
    Lancet (London, England), 2001, May-26, Volume: 357, Issue:9269

    Topics: Acidosis; Adolescent; Adult; Anesthetics, Intravenous; Animals; Cardiac Output; Craniocerebral Traum

2001
Propofol.
    Journal of neurosurgery, 2002, Volume: 96, Issue:6

    Topics: Adolescent; Heart Failure; Humans; Infusions, Intravenous; Male; Propofol; Renal Insufficiency; Rhab

2002
Propofol.
    Journal of neurosurgery, 2002, Volume: 96, Issue:6

    Topics: Adult; Heart Failure; Humans; Infusions, Intravenous; Male; Propofol; Renal Insufficiency; Rhabdomyo

2002