propofol has been researched along with Substance-Related Disorders in 48 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Substance-Related Disorders: Disorders related to substance use or abuse.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg)." | 7.74 | Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. ( Babu, KM; Boyer, EW; Ganetsky, M, 2007) |
| "An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg)." | 3.74 | Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. ( Babu, KM; Boyer, EW; Ganetsky, M, 2007) |
| "Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness." | 2.47 | Clinical effects and lethal and forensic aspects of propofol. ( Levy, RJ, 2011) |
| "Propofol has yet not arrived on the local black markets." | 2.47 | [Assessment of the addictive risk of propofol]. ( Bonnet, U, 2011) |
| "Propofol has shown strong addictive properties in rats and humans." | 1.62 | The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats. ( Chen, J; Dong, Z; Huang, B; Jiang, C; Lian, Q; Lin, H; Wu, B, 2021) |
| " Long-term use of propofol resulted in decreased activities of mice (activity trajectory, line crossing, rearing time, scratching times and defecating frequency)." | 1.56 | Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms. ( Chen, Q; Du, J; Han, Y; Li, J; Li, S; Su, B; Wang, X; Wei, X, 2020) |
| "Propofol has been demonstrated as a drug of abuse in humans." | 1.48 | Glucocorticoid receptor in rat nucleus accumbens: Its roles in propofol addictions. ( Abdullah, T; Ge, RS; Lian, Q; Lin, W; Su, Y; Wang, B; Wang, H; Wu, B, 2018) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| "Propofol was the major cause of death in 33 cases (85%), in 8 cases including 7 with propofol, an unintentional accident was recorded and 29 were determined to be suicide." | 1.46 | [Deaths from propofol abuse : Survey of institutes of forensic medicine in Germany, Austria and Switzerland]. ( Iwunna, J; Maier, C; Mußhoff, F; Tsokos, M, 2017) |
| " The incidence of adverse effects was then compared." | 1.43 | Safety of Propofol Used as a Rescue Agent During Colonoscopy. ( Hunt, KK; Korsten, MA; Okeke, FC; Rosman, AS; Shaw, S, 2016) |
| " The propofol self-administration model was established by a fixed ratio 1 (FR1) schedule of reinforced dosing over successive 14days in rats." | 1.43 | Glucocorticoid receptor mediated the propofol self-administration by dopamine D1 receptor in nucleus accumbens. ( Chen, Z; Dong, Z; Ge, RS; Lian, Q; Liang, Y; Lin, W; Wang, B; Wang, S; Wu, B; Zhang, G, 2016) |
| "Propofol is an addictive drug, and the problem of its abuse and dependence has occurred." | 1.42 | Increased use in propofol and reported patterns of adverse events among anesthetics in Korea. ( Kim, MH; Park, BJ; Park, HJ; Shin, JY, 2015) |
| "Propofol was detected in 131 cases (0." | 1.39 | Deaths from recreational use of propofol in Korea. ( Baeck, S; Chung, H; Han, E; Jung, S; Lee, S, 2013) |
| "Propofol is a short acting intravenous anaesthetic, active agent of Diprivan." | 1.35 | Evaluation of a fatal propofol intoxication due to self administration. ( Klausz, G; Kristóf, I; Róna, K; Töro, K, 2009) |
| "We report a patient with drug abuse who developed multiple psychotic symptoms including euphoria, excitement, hallucination and delirium during sedation with propofol under spinal anesthesia." | 1.30 | [A patient with drug abuse who developed multiple psychotic symptoms during sedation with propofol]. ( Kitajima, T; Mishio, M; Okuda, Y; Yamaguchi, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (14.58) | 18.2507 |
| 2000's | 15 (31.25) | 29.6817 |
| 2010's | 23 (47.92) | 24.3611 |
| 2020's | 3 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kwon, NJ | 1 |
| Kim, HJ | 1 |
| Cho, S | 1 |
| Lee, MA | 1 |
| Han, E | 2 |
| Chen, Q | 1 |
| Li, S | 1 |
| Han, Y | 1 |
| Wei, X | 1 |
| Du, J | 1 |
| Wang, X | 1 |
| Su, B | 1 |
| Li, J | 3 |
| Dong, Z | 2 |
| Huang, B | 1 |
| Jiang, C | 1 |
| Chen, J | 1 |
| Lin, H | 1 |
| Lian, Q | 3 |
| Wu, B | 3 |
| Maas, A | 1 |
| Maier, C | 3 |
| Iwersen-Bergmann, S | 1 |
| Madea, B | 1 |
| Hess, C | 1 |
| Lin, W | 2 |
| Wang, H | 1 |
| Abdullah, T | 1 |
| Wang, B | 2 |
| Su, Y | 1 |
| Ge, RS | 2 |
| Zhu, W | 1 |
| Zhang, W | 1 |
| Ding, Z | 1 |
| Huang, Y | 1 |
| Lu, L | 1 |
| Mannocchi, G | 1 |
| Napoleoni, F | 1 |
| Napoletano, S | 1 |
| Pantano, F | 1 |
| Santoni, M | 1 |
| Tittarelli, R | 1 |
| Arbarello, P | 1 |
| Jung, S | 1 |
| Baeck, S | 1 |
| Lee, S | 1 |
| Chung, H | 1 |
| Shin, JY | 2 |
| Lee, SH | 1 |
| Shin, SM | 1 |
| Kim, MH | 2 |
| Park, SG | 1 |
| Park, BJ | 2 |
| Park, HJ | 1 |
| Okeke, FC | 1 |
| Shaw, S | 1 |
| Hunt, KK | 1 |
| Korsten, MA | 1 |
| Rosman, AS | 1 |
| Schifano, F | 1 |
| Papanti, GD | 1 |
| Orsolini, L | 1 |
| Corkery, JM | 1 |
| Liang, Y | 1 |
| Chen, Z | 1 |
| Zhang, G | 1 |
| Wang, S | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| Iwunna, J | 1 |
| Tsokos, M | 1 |
| Mußhoff, F | 1 |
| Klausz, G | 1 |
| Róna, K | 1 |
| Kristóf, I | 1 |
| Töro, K | 1 |
| Hartle, A | 1 |
| Malhotra, S | 1 |
| Sen, A | 1 |
| Gilboy, N | 1 |
| Levy, RJ | 1 |
| Bryson, EO | 1 |
| Frost, EA | 1 |
| Koopmann, A | 1 |
| von der Goltz, C | 1 |
| Hermann, D | 1 |
| Kiefer, F | 1 |
| Burns, K | 1 |
| Monroe, T | 1 |
| Hamza, H | 1 |
| Stocks, G | 1 |
| Scimeca, PD | 1 |
| Cowan, R | 1 |
| Xiong, M | 2 |
| Ye, JH | 2 |
| Zhang, C | 1 |
| Bonnet, U | 1 |
| Roh, S | 1 |
| Park, JM | 1 |
| Kim, DJ | 1 |
| Kim, DK | 1 |
| Leclerc-Springer, J | 1 |
| Subramaniam, K | 1 |
| Gowda, RM | 1 |
| Rosa, U | 1 |
| Weetman, DB | 1 |
| Mascardo, LA | 1 |
| Ross, MB | 1 |
| Abramowitz, PW | 1 |
| Gold, MS | 1 |
| Melker, RJ | 1 |
| Dennis, DM | 1 |
| Morey, TE | 1 |
| Bajpai, LK | 1 |
| Pomm, R | 1 |
| Frost-Pineda, K | 1 |
| Fodale, V | 1 |
| Pratico, C | 1 |
| Tescione, M | 1 |
| Tanania, S | 1 |
| Lucanto, T | 1 |
| Santamaria, LB | 1 |
| Roussin, A | 1 |
| Mirepoix, M | 1 |
| Lassabe, G | 1 |
| Dumestre-Toulet, V | 1 |
| Gardette, V | 1 |
| Montastruc, JL | 1 |
| Lapeyre-Mestre, M | 1 |
| Dexter, F | 1 |
| Wischmeyer, PE | 1 |
| Johnson, BR | 1 |
| Wilson, JE | 1 |
| Dingmann, C | 1 |
| Bachman, HM | 1 |
| Roller, E | 1 |
| Tran, ZV | 1 |
| Henthorn, TK | 1 |
| Ganetsky, M | 1 |
| Babu, KM | 1 |
| Boyer, EW | 1 |
| Li, KY | 1 |
| Xiao, C | 1 |
| Delphin, E | 1 |
| Sneyd, JR | 1 |
| Zacny, JP | 1 |
| Lichtor, JL | 1 |
| Thompson, W | 1 |
| Apfelbaum, JL | 1 |
| Yamaguchi, S | 1 |
| Mishio, M | 1 |
| Okuda, Y | 1 |
| Kitajima, T | 1 |
| Odell, M | 1 |
| LeSage, MG | 1 |
| Stafford, D | 1 |
| Glowa, JR | 1 |
| Ward, CF | 1 |
| Follette, JW | 1 |
| Farley, WJ | 1 |
| Gündel, H | 1 |
| Kuhs, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894] | 124 participants (Actual) | Observational | 2016-09-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for propofol and Substance-Related Disorders
| Article | Year |
|---|---|
Novel psychoactive substances: the pharmacology of stimulants and hallucinogens.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Central Nervous System Stimulants; Fever; Hallucinog | 2016 |
Clinical effects and lethal and forensic aspects of propofol.
Topics: Accidents; Acidosis; Acute Kidney Injury; Bacteremia; Bradycardia; Drug Overdose; Dyslipidemias; For | 2011 |
Propofol abuse.
Topics: Anesthetics, Intravenous; Humans; Incidence; Prevalence; Propofol; Substance-Related Disorders | 2011 |
[Assessment of the addictive risk of propofol].
Topics: Administration, Oral; Anesthetics, Intravenous; Animals; Disease Models, Animal; Electroconvulsive T | 2011 |
44 other studies available for propofol and Substance-Related Disorders
| Article | Year |
|---|---|
Development of a LC-MS/MS method for determination of propofol-glucuronide in hair and preliminary study on relationships between dose and hair concentration.
Topics: Adult; Chromatography, Liquid; Female; Forensic Toxicology; Glucuronides; Hair; Humans; Hypnotics an | 2020 |
Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms.
Topics: Anesthetics; Animals; Behavior, Animal; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins | 2020 |
The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cues; Male; N | 2021 |
Simultaneous extraction of propofol and propofol glucuronide from hair followed by validated LC-MS/MS analyses.
Topics: Adult; Chromatography, Liquid; Female; Glucuronides; Hair; Humans; Illicit Drugs; Limit of Detection | 2017 |
Glucocorticoid receptor in rat nucleus accumbens: Its roles in propofol addictions.
Topics: Anesthetics, Intravenous; Animals; Behavior, Addictive; Dexamethasone; Male; Microinjections; Nucleu | 2018 |
The abuse of anesthetic propofol: associated with cognitive impairment.
Topics: Anesthetics; Animals; Cognitive Dysfunction; Humans; Models, Biological; Propofol; Signal Transducti | 2018 |
Fatal self administration of tramadol and propofol: a case report.
Topics: Analgesics, Opioid; Drug Overdose; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair; | 2013 |
Deaths from recreational use of propofol in Korea.
Topics: Adolescent; Adult; Drug Overdose; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; | 2013 |
Prescribing patterns of the four most commonly used sedatives in endoscopic examination in Korea: propofol, midazolam, diazepam, and lorazepam.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diazepam; Drug Prescriptions; Drug Utilization Review; E | 2015 |
Increased use in propofol and reported patterns of adverse events among anesthetics in Korea.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Anesthetics, Intravenous; Child; C | 2015 |
Safety of Propofol Used as a Rescue Agent During Colonoscopy.
Topics: Age Factors; Aged; Colonoscopy; Conscious Sedation; Female; Humans; Hypnotics and Sedatives; Male; M | 2016 |
Glucocorticoid receptor mediated the propofol self-administration by dopamine D1 receptor in nucleus accumbens.
Topics: Aldosterone; Animals; Corticosterone; Dexamethasone; Disease Models, Animal; Dose-Response Relations | 2016 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
[Deaths from propofol abuse : Survey of institutes of forensic medicine in Germany, Austria and Switzerland].
Topics: Adult; Anesthetics, Intravenous; Anesthetists; Austria; Cause of Death; Documentation; Female; Germa | 2017 |
Evaluation of a fatal propofol intoxication due to self administration.
Topics: Accidents; Drug Overdose; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; | 2009 |
The safety of propofol.
Topics: Anesthetics, Intravenous; Drug Labeling; Humans; Propofol; Substance-Related Disorders | 2009 |
Schedule of controlled substances; placement of fospropofol into schedule IV. Final rule.
Topics: Anesthetics, Intravenous; Commerce; Drug and Narcotic Control; Humans; Hypnotics and Sedatives; Prop | 2009 |
Propofol is safely and widely used in emergency departments.
Topics: Anesthetics, Intravenous; Emergency Service, Hospital; Humans; Professional Practice; Propofol; Subs | 2009 |
Decrease the risk of diversion: increase the control.
Topics: Anesthetics, General; Humans; Injections, Intravenous; Propofol; Substance-Related Disorders | 2010 |
Propofol addiction initiated by anesthetic use.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Colonoscopy; Crohn Disease; Euphoria; Fema | 2011 |
Proposal to schedule propofol draws reactions.
Topics: Anesthetics, Intravenous; Animals; Legislation, Drug; Propofol; Societies; Substance-Related Disorde | 2011 |
The misuse and abuse of propofol.
Topics: Health Personnel; Humans; Hypnotics and Sedatives; Propofol; Substance-Related Disorders; United Sta | 2011 |
Upregulation of DeltaFosB by propofol in rat nucleus accumbens.
Topics: Anesthetics, Intravenous; Animals; Blotting, Western; Central Nervous System Depressants; Ethanol; G | 2011 |
A case of propofol dependence after repeated use for endoscopy.
Topics: Adult; Deep Sedation; Endoscopy; Humans; Hypnotics and Sedatives; Male; Propofol; Substance-Related | 2011 |
Propofol use for sedation or sedation for propofol use?
Topics: Female; Humans; Hypnotics and Sedatives; Physicians; Propofol; Republic of Korea; Substance-Related | 2012 |
[Life-threatening fentanyl and propofol addiction: interview with a survivor].
Topics: Adult; Analgesics, Opioid; Anesthesiology; Anesthetics, Intravenous; Female; Fentanyl; Humans; Nalox | 2012 |
Delayed neuroexcitatory symptoms following propofol sedation in a patient with polysubstance abuse.
Topics: Akathisia, Drug-Induced; Alcoholism; Conscious Sedation; Electroencephalography; Humans; Hypnotics a | 2003 |
Propofol as a drug of diversion.
Topics: Anesthetics, Intravenous; Drug and Narcotic Control; Humans; Illicit Drugs; Personnel, Hospital; Pro | 2004 |
Fentanyl abuse and dependence: further evidence for second hand exposure hypothesis.
Topics: Analgesics, Opioid; Anesthesiology; Fentanyl; Humans; Narcotics; Occupational Exposure; Operating Ro | 2006 |
Evidence of acute tolerance to remifentanil in intensive care but not in anesthesia.
Topics: Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Cran | 2006 |
Death related to a recreational abuse of propofol at therapeutic dose range.
Topics: Adult; Anesthetics, Intravenous; Fatal Outcome; Humans; Male; Propofol; Recreation; Substance-Relate | 2006 |
Pediatric emergency medicine: legal briefs.
Topics: Acidosis; Administration, Cutaneous; Adult; Asphyxia; Brain Damage, Chronic; Burns, Chemical; Child; | 2007 |
Detecting diversion of anesthetic drugs by providers.
Topics: Anesthesiology; Anesthetics; Clinical Pharmacy Information Systems; Drug and Narcotic Control; Human | 2007 |
A survey of propofol abuse in academic anesthesia programs.
Topics: Academic Medical Centers; Anesthesiology; Data Collection; Internship and Residency; Physician Impai | 2007 |
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy.
Topics: Acetaminophen; Adolescent; Algorithms; Chlorpheniramine; Dextromethorphan; Drug Combinations; Drug O | 2007 |
Nanomolar propofol stimulates glutamate transmission to dopamine neurons: a possible mechanism of abuse potential?
Topics: Animals; Dopamine; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Neurons; | 2008 |
Propofol at a subanesthetic dose may have abuse potential in healthy volunteers.
Topics: Hospital Volunteers; Humans; Propofol; Substance-Related Disorders | 1994 |
Propofol at a subanesthetic dose may have abuse potential in healthy volunteers.
Topics: Adult; Anesthesiology; Choice Behavior; Female; Humans; Male; Memory; Propofol; Psychomotor Performa | 1993 |
[A patient with drug abuse who developed multiple psychotic symptoms during sedation with propofol].
Topics: Adult; Anesthesia, Spinal; Antipsychotic Agents; Haloperidol; Humans; Hypnotics and Sedatives; Intra | 1998 |
Propofol abuse.
Topics: Anesthetics, Intravenous; Humans; Male; Propofol; Substance-Related Disorders | 1999 |
Abuse liability of the anesthetic propofol: self-administration of propofol in rats under fixed-ratio schedules of drug delivery.
Topics: Anesthetics, Intravenous; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Me | 2000 |
Substance abuse. Now, and for some time to come.
Topics: Adult; Anesthesiology; Drug and Narcotic Control; Fentanyl; Humans; Male; Propofol; Substance-Relate | 1992 |
Anesthesiologist addicted to propofol.
Topics: Adult; Anesthesiology; Humans; Propofol; Substance-Related Disorders | 1992 |
[A case report on a 9-day-long abuse of propofol].
Topics: Adult; Humans; Male; Propofol; Substance-Related Disorders; Time Factors | 1992 |