propofol has been researched along with Shock, Septic in 31 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to assess the relationship between the use of dexmedetomidine and the incidence of acute kidney injury (AKI) in septic shock patients undergoing mechanical ventilation and reveal the potential mechanism." | 7.96 | Dexmedetomidine protects against acute kidney injury in patients with septic shock. ( Chen, M; Gong, F; Hong, J; Hu, B; Jiang, L; Liu, J; Mo, S; Shi, K; Sun, R; Tu, Y; Xu, L; Yang, X; Zheng, Y, 2020) |
| "We previously found that propofol attenuated the mortality rate and inflammatory responses during endotoxemia in rats; however, whether propofol retains its antiinflammatory effects during hypothermia has not been determined." | 7.74 | The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Taniguchi, T, 2007) |
| "This study aimed to assess the relationship between the use of dexmedetomidine and the incidence of acute kidney injury (AKI) in septic shock patients undergoing mechanical ventilation and reveal the potential mechanism." | 3.96 | Dexmedetomidine protects against acute kidney injury in patients with septic shock. ( Chen, M; Gong, F; Hong, J; Hu, B; Jiang, L; Liu, J; Mo, S; Shi, K; Sun, R; Tu, Y; Xu, L; Yang, X; Zheng, Y, 2020) |
| "To compare the development of clinically significant hemodynamic event (ie, hypotension or bradycardia) in adults with septic shock receiving either propofol or dexmedetomidine." | 3.96 | Effects From Continuous Infusions of Dexmedetomidine and Propofol on Hemodynamic Stability in Critically Ill Adult Patients With Septic Shock. ( Hammond, DA; Nelson, KM; Patel, GP, 2020) |
| "The mortality rates in the present study were extremely high; further hypotension and elevations in plasma pro-inflammatory and anti-inflammatory cytokine concentrations after endotoxin injection were not attenuated by mild hyperthermia between 39 °C and 40 °C, but they were attenuated by propofol with mild hyperthermia." | 3.78 | Effects of propofol with hyperthermia in a rat model of endotoxemic shock. ( Mukawa, C; Taniguchi, T, 2012) |
| "We previously found that propofol attenuated the mortality rate and inflammatory responses during endotoxemia in rats; however, whether propofol retains its antiinflammatory effects during hypothermia has not been determined." | 3.74 | The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Taniguchi, T, 2007) |
| "Propofol was then replaced by dexmedetomidine and a second set of data was obtained after 4 hours of dexmedetomidine infusion." | 2.90 | The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial. ( Arnemann, P; D'Egidio, A; Ertmer, C; Frati, G; Greco, E; Hessler, M; Kampmeier, TG; Morelli, A; Orecchioni, A; Rehberg, SW; Sanfilippo, F; Santonocito, C; Westphal, M, 2019) |
| "Forty-five patients with septic shock were assigned to 3 groups (midazolam group, propofol group, and dexmedetomidine group) randomly." | 2.82 | [Clinical application of different sedation regimen in patients with septic shock]. ( Guo, F; Huang, HY; Tu, LY; Wang, Q; Yan, CY; Yu, X, 2016) |
| "Forty-three septic shock patients who were undergoing early goal-directed therapy resuscitated within 24 h were enrolled." | 2.80 | Propofol increases preload dependency in septic shock patients. ( Guo, F; Huang, Y; Li, Q; Liu, L; Peng, X; Qiu, H; Yang, Y; Yu, T, 2015) |
| "A total of 20 patients with septic shock who required mechanical ventilation were included in this study." | 2.73 | Comparative effects of propofol vs dexmedetomidine on cerebrovascular carbon dioxide reactivity in patients with septic shock. ( Hinohara, H; Kadoi, Y; Kawauchi, C; Kunimoto, F; Saito, S, 2008) |
| "Propofol (PPF) has previously been shown to inhibit the inflammatory response to septic shock." | 1.51 | Propofol regulates imbalanced Th17/Treg responses in lipopolysaccharide-induced septic shock rats. ( Fang, X; Huang, LJ; Wang, SY; Xie, L, 2019) |
| "Forty early septic shock patients were included in the study and administered either the loading dose infusion of propofol (n = 20, group P) of 1 mg/kg over 15 minutes followed by a maintenance dose of 1 to 3 mg/kg per hour (n = 20, group P), or a loading dose of dexmedetomidine 1 microg/kg over 10 minutes followed by a maintenance of 0." | 1.35 | Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: a pilot study. ( Kargi, M; Memiş, D; Sut, N, 2009) |
| "We reviewed 159 septic shock patients admitted to our intensive care unit (ICU) over a 40-month period to study the association between induction agent and clinical outcome, including vasopressor, inotrope, and steroid therapy." | 1.34 | Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. ( McKeown, DW; Ray, DC, 2007) |
| "Human septic shock can be replicated in the endotoxaemic pig." | 1.31 | Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock. ( Basu, S; Eriksson, MB; Kiiski, R; Larsson, AO; Mutschler, DK; Nordgren, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (38.71) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, W | 1 |
| Xu, Y | 1 |
| Du, K | 1 |
| Morelli, A | 4 |
| Sanfilippo, F | 4 |
| Rehberg, SW | 2 |
| Ertmer, C | 4 |
| Xie, L | 1 |
| Huang, LJ | 1 |
| Wang, SY | 1 |
| Fang, X | 1 |
| Liu, J | 1 |
| Shi, K | 1 |
| Hong, J | 1 |
| Gong, F | 1 |
| Mo, S | 1 |
| Chen, M | 1 |
| Zheng, Y | 1 |
| Jiang, L | 1 |
| Xu, L | 1 |
| Tu, Y | 1 |
| Hu, B | 1 |
| Yang, X | 1 |
| Sun, R | 1 |
| Nelson, KM | 1 |
| Patel, GP | 1 |
| Hammond, DA | 1 |
| Arnemann, P | 1 |
| Hessler, M | 1 |
| Kampmeier, TG | 1 |
| D'Egidio, A | 1 |
| Orecchioni, A | 1 |
| Santonocito, C | 1 |
| Frati, G | 1 |
| Greco, E | 1 |
| Westphal, M | 1 |
| Petitjeans, F | 1 |
| Leroy, S | 1 |
| Geloen, A | 1 |
| Pichot, C | 1 |
| Ghignone, M | 1 |
| Quintin, L | 1 |
| Rehberg, S | 2 |
| Park, JH | 1 |
| Hampton, SR | 1 |
| Derry, KL | 1 |
| Penna, GL | 1 |
| Fialho, FM | 1 |
| Kurtz, P | 1 |
| Japiassú, AM | 1 |
| Kalichsztein, M | 1 |
| Nobre, G | 1 |
| Villela, NR | 1 |
| Bouskela, E | 1 |
| Yu, T | 3 |
| Peng, X | 2 |
| Liu, L | 2 |
| Li, Q | 2 |
| Huang, Y | 1 |
| Guo, F | 3 |
| Yang, Y | 3 |
| Qiu, H | 3 |
| Franci, P | 1 |
| Dotto, G | 1 |
| Cattai, A | 1 |
| Pasotto, D | 1 |
| Vistisen, ST | 1 |
| Longhini, F | 1 |
| Wang, Q | 1 |
| Yan, CY | 1 |
| Huang, HY | 1 |
| Yu, X | 1 |
| Tu, LY | 1 |
| Lai, Y | 1 |
| Zhang, J | 1 |
| Han, N | 1 |
| Memiş, D | 1 |
| Kargi, M | 1 |
| Sut, N | 1 |
| Mukawa, C | 1 |
| Taniguchi, T | 4 |
| Ting, TW | 1 |
| Lee, JH | 1 |
| Ziser, A | 1 |
| Strickland, RA | 1 |
| Murray, MJ | 1 |
| Kanakura, H | 3 |
| Takemoto, Y | 1 |
| Kidani, Y | 1 |
| Yamamoto, K | 2 |
| Tsao, CM | 1 |
| Ho, ST | 1 |
| Chen, A | 1 |
| Wang, JJ | 1 |
| Tsai, SK | 1 |
| Wu, CC | 1 |
| Gao, J | 1 |
| Zeng, B | 1 |
| Zhou, L | 1 |
| Yuan, S | 1 |
| Zhang, S | 1 |
| Ray, DC | 1 |
| McKeown, DW | 1 |
| Kadoi, Y | 1 |
| Saito, S | 1 |
| Kawauchi, C | 1 |
| Hinohara, H | 1 |
| Kunimoto, F | 1 |
| Yu, HP | 1 |
| Tang, GJ | 1 |
| Liaw, WJ | 1 |
| Yien, HW | 1 |
| Lee, TY | 1 |
| Basu, S | 1 |
| Mutschler, DK | 1 |
| Larsson, AO | 1 |
| Kiiski, R | 1 |
| Nordgren, A | 1 |
| Eriksson, MB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dexmedetomidine Improve Microcirculatory Alterations in Initial Resuscitated Septic Shock Patients[NCT02270281] | Phase 4 | 44 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propofol and Shock, Septic
| Article | Year |
|---|---|
[Advances in research on the effects of propofol on the pulmonary circulation in septic shock].
Topics: Humans; Propofol; Pulmonary Circulation; Shock, Septic | 2009 |
4 trials available for propofol and Shock, Septic
| Article | Year |
|---|---|
The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial.
Topics: Acid-Base Equilibrium; Adrenergic alpha-Agonists; Cross-Over Studies; Deep Sedation; Dexmedetomidine | 2019 |
Propofol increases preload dependency in septic shock patients.
Topics: Aged; Aged, 80 and over; Female; Hemodynamics; Humans; Hypnotics and Sedatives; Male; Midazolam; Mid | 2015 |
[Clinical application of different sedation regimen in patients with septic shock].
Topics: Anesthesia; Conscious Sedation; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Intensive | 2016 |
Comparative effects of propofol vs dexmedetomidine on cerebrovascular carbon dioxide reactivity in patients with septic shock.
Topics: Aged; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulation; Conscious Sedation; Dexmedet | 2008 |
26 other studies available for propofol and Shock, Septic
| Article | Year |
|---|---|
Comparison of Propofol and Dexmedetomidine Sedation in Septic Shock.
Topics: Conscious Sedation; Cross-Over Studies; Dexmedetomidine; Humans; Hypnotics and Sedatives; Norepineph | 2019 |
The authors reply.
Topics: Cross-Over Studies; Dexmedetomidine; Humans; Norepinephrine; Propofol; Shock, Septic | 2019 |
Propofol regulates imbalanced Th17/Treg responses in lipopolysaccharide-induced septic shock rats.
Topics: Animals; Cytokines; Gene Expression Regulation; Janus Kinases; Lipopolysaccharides; Male; Propofol; | 2019 |
Dexmedetomidine protects against acute kidney injury in patients with septic shock.
Topics: Acute Kidney Injury; Adult; Aged; Analgesics, Non-Narcotic; China; Cohort Studies; Dexmedetomidine; | 2020 |
Effects From Continuous Infusions of Dexmedetomidine and Propofol on Hemodynamic Stability in Critically Ill Adult Patients With Septic Shock.
Topics: Adult; Aged; Bradycardia; Critical Care; Critical Care Outcomes; Critical Illness; Dexmedetomidine; | 2020 |
On the Right Track, Finally?
Topics: Cross-Over Studies; Dexmedetomidine; Humans; Norepinephrine; Propofol; Shock, Septic | 2019 |
The authors reply.
Topics: Cross-Over Studies; Dexmedetomidine; Humans; Norepinephrine; Propofol; Shock, Septic | 2019 |
Use of Dexmedetomidine for Deep Sedation and Reduction of Vasopressor Requirement?
Topics: Conscious Sedation; Cross-Over Studies; Deep Sedation; Dexmedetomidine; Humans; Hypnotics and Sedati | 2019 |
The authors reply.
Topics: Cross-Over Studies; Dexmedetomidine; Humans; Norepinephrine; Propofol; Shock, Septic | 2019 |
Changing sedative infusion from propofol to midazolam improves sublingual microcirculatory perfusion in patients with septic shock.
Topics: Aged; Algorithms; APACHE; Female; Hemodynamics; Humans; Hypnotics and Sedatives; Male; Microcirculat | 2013 |
Lethal septic shock after dental scaling in a healthy dog due to Ochrobactrum anthropi-contaminated propofol.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Dental Scaling; Dog Diseases; Dogs; Drug | 2015 |
Propofol—or regression toward the mean—increases preload dependency.
Topics: Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Propofol; Shock, Septic | 2015 |
Response to letter to the editor on the article "Propofol increases preload dependency in septic shock patients".
Topics: Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Propofol; Shock, Septic | 2015 |
Different effects of propofol and dexmedetomidine on preload dependency in endotoxemic shock with norepinephrine infusion.
Topics: Animals; Blood Pressure; Cardiac Output; Dexmedetomidine; Endotoxemia; Heart Rate; Norepinephrine; P | 2015 |
Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Coloring Agents; Critical Illness; Dexmedetomidine; Female; Hemodyna | 2009 |
Effects of propofol with hyperthermia in a rat model of endotoxemic shock.
Topics: Acidosis; Animals; Carbon Dioxide; Combined Modality Therapy; Cytokines; Drug Evaluation, Preclinica | 2012 |
Acute pancreatitis after propofol infusion in a teenage patient.
Topics: Acute Disease; Adolescent; Anesthetics, Intravenous; Conscious Sedation; Fatal Outcome; Female; Huma | 2012 |
Propofol does not induce pulmonary dysfunction in stressed endotoxic pigs receiving Intralipid.
Topics: Animals; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Hemodynamics; Lung; Male; Pro | 2003 |
Effects of ketamine and propofol on the ratio of interleukin-6 to interleukin-10 during endotoxemia in rats.
Topics: Anesthetics, Dissociative; Animals; Disease Models, Animal; Endotoxins; Hemodynamics; Hypnotics and | 2003 |
Propofol ameliorates liver dysfunction and inhibits aortic superoxide level in conscious rats with endotoxic shock.
Topics: Animals; Antioxidants; Blood Glucose; Blood Pressure; Endotoxins; Escherichia coli; Heart Rate; Kidn | 2003 |
Therapeutic effect of propofol in the treatment of endotoxin-induced shock in rats.
Topics: Animals; Free Radical Scavengers; Lipopolysaccharides; Lung; Male; Nitric Oxide; Peroxidase; Propofo | 2003 |
Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock.
Topics: Aged; Anesthetics, Intravenous; Etomidate; Female; Fentanyl; Humans; Intensive Care Units; Ketamine; | 2007 |
The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia.
Topics: Anesthetics, Intravenous; Animals; Anti-Inflammatory Agents; Blood Gas Analysis; Blood Pressure; Dis | 2007 |
Pseudomonas cepacia induced septic shock after propofol--a case report.
Topics: Adult; Anesthetics, Intravenous; Burkholderia cepacia; Drug Contamination; Female; Humans; Postopera | 2000 |
Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock.
Topics: Anesthetics, Intravenous; Animals; Dinoprost; Endotoxemia; Escherichia coli Infections; F2-Isoprosta | 2001 |
Effects of posttreatment with propofol on mortality and cytokine responses to endotoxin-induced shock in rats.
Topics: Animals; Carbon Dioxide; Hemodynamics; Interleukin-6; Male; Oxygen; Propofol; Prospective Studies; R | 2002 |