propofol has been researched along with Sepsis in 44 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among mechanically ventilated adults with sepsis who were being treated with recommended light-sedation approaches, outcomes in patients who received dexmedetomidine did not differ from outcomes in those who received propofol." | 9.41 | Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis. ( Anzueto, A; Bernard, GR; Brummel, NE; Bui, LN; Devlin, JW; Dittus, RS; Duprey, MS; Ely, EW; Girard, TD; Gropper, MA; Guntupalli, KK; Hoskins, AS; Hughes, CG; Jackson, JC; Kiehl, AL; Mailloux, PT; O'Neal, HR; Orun, OM; Pandharipande, PP; Patel, MB; Pun, BT; Raman, R; Sanders, RD; Snyder, A; Stashenko, GJ; Stollings, JL; Swan, JT, 2021) |
| "In adults with severe sepsis and detectable plasma cell-free hemoglobin, treatment with acetaminophen within 24 hours of ICU admission may reduce oxidative injury and improve renal function." | 9.20 | Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. ( Bastarache, JA; Bernard, GR; Janz, DR; Oates, JA; Rice, TW; Roberts, LJ; Sills, G; Ware, LB; Warren, MA; Wickersham, N, 2015) |
| "To compare the effects of an intravenous infusion of propofol and the alpha-2 adrenoceptor, dexmedetomidine, on inflammatory responses and intraabdominal pressure (IAP) in severe sepsis after abdominal surgery, specifically, serum cytokine levels (interleukin [IL]-1, IL-6, and tumor necrosis factor [TNF]-alpha) and IAP." | 9.14 | Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. ( Memis, D; Sut, N; Tasdogan, M; Yuksel, M, 2009) |
| "We presented a sepsis outbreak caused by Serratia marcescens from contaminated propofol to raise awareness." | 7.91 | Serratia marcescens sepsis outbreak caused by contaminated propofol. ( Aksit-Barik, S; Arda, B; Cilli, F; Gulay, Z; Kepeli, N; Nazli-Zeka, A; Ozinel, MA; Sipahi, OR; Ulusoy, S, 2019) |
| "Taken together, the present study showed that propofol can protect against sepsis-induced liver dysfunction through suppressing hepatic oxidative stress, lipid peroxidation, inflammation, and drug biotransformation and interactions in the liver." | 7.88 | Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions. ( Chen, JT; Chen, RM; Lee, YW; Lin, YW; Tsai, HC; Wu, GJ, 2018) |
| "We have shown that systemic attenuation of inflammation by the volatile anaesthetic sevoflurane did not translate into attenuated neuro-inflammation in this LPS-induced inflammation model." | 7.85 | Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study. ( Baumann, L; Beck-Schimmer, B; Booy, C; Eugster, P; Hasler, M; Restin, T; Schläpfer, M, 2017) |
| "A multicenter, retrospective, propensity-matched pilot study was conducted comparing patients with sepsis or severe sepsis who received CIV propofol for sedation to those who did not." | 7.83 | Effects of propofol on vasopressor use in patients with sepsis and severe sepsis: A pilot study. ( Boucher, AN; Jones, GM; Kimmons, LA; Marler, J; Mohrien, K; Oliphant, CS; Vandigo, JE, 2016) |
| "This is the first study to assess prolonged effects of sepsis and long-term application of volatile sedatives compared to propofol on survival, cardiovascular, inflammatory and end organ parameters." | 7.81 | Propofol increases morbidity and mortality in a rat model of sepsis. ( Beck-Schimmer, B; Bonini, MG; Dull, RO; Mao, M; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE; Z'Graggen, BR, 2015) |
| "The aim of this study was to determine the effect of etomidate and propofol pretreatment on the expression of glucocorticoid receptor and the prognosis of sepsis." | 7.81 | Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats. ( Li, RM; Liu, N; Shen, L; Wang, C; Xiong, JY; Zhang, Y, 2015) |
| "To explore the effects of propofol on the outcomes of rats with sepsis." | 7.77 | Effects of propofol on the outcomes of rats with sepsis. ( Bao, HG; Li, S, 2011) |
| "Propofol treatment could protect kidney from sepsis-induced AKI by increasing BMP-7 expression, decreasing inflammatory cytokines and inhibiting oxidative stress." | 7.77 | Propofol increases bone morphogenetic protein-7 and decreases oxidative stress in sepsis-induced acute kidney injury. ( Chen, HW; Chou, W; Hsing, CH; Wang, JJ; Yeh, CH, 2011) |
| "We concluded that iNOS-induced NO might be involved in the manifestation of the BHF and BLF components of the SAP spectrum during endotoxemia when low-dose propofol is used, and this effect of NO is blunted when high-dose propofol is administered." | 7.75 | Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009) |
| "Pretreatment with propofol attenuated diaphragmatic dysfunction induced by septic peritonitis in hamsters assessed by contractile profiles and endurance capacity." | 7.71 | Propofol attenuates diaphragmatic dysfunction induced by septic peritonitis in hamsters. ( Kodama, S; Mikawa, K; Nishina, K; Obara, H, 2001) |
| "Among mechanically ventilated adults with sepsis who were being treated with recommended light-sedation approaches, outcomes in patients who received dexmedetomidine did not differ from outcomes in those who received propofol." | 5.41 | Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis. ( Anzueto, A; Bernard, GR; Brummel, NE; Bui, LN; Devlin, JW; Dittus, RS; Duprey, MS; Ely, EW; Girard, TD; Gropper, MA; Guntupalli, KK; Hoskins, AS; Hughes, CG; Jackson, JC; Kiehl, AL; Mailloux, PT; O'Neal, HR; Orun, OM; Pandharipande, PP; Patel, MB; Pun, BT; Raman, R; Sanders, RD; Snyder, A; Stashenko, GJ; Stollings, JL; Swan, JT, 2021) |
| "An outbreak of severe sepsis in patients who underwent minor procedures in an operating theatre during two consecutive days is described and analysed in this study." | 5.36 | Outbreak of severe sepsis due to contaminated propofol: lessons to learn. ( Dorresteijn, JJ; Harbers, JB; Huisman, I; Klein, J; Muller, AE; Rietveld, AP; Roos, PJ; van Steenbergen, JE; Vos, MC, 2010) |
| "Propofol has inhibited the hepatic NF-kappaB activation and the pro-inflammatory cytokine response during polymicrobial sepsis in rats." | 5.35 | Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats. ( Li, JG; Liang, H; Song, XM; Wang, CY; Wang, YL; Zhang, ZZ; Zhou, Q, 2009) |
| "Sepsis was induced in rats by cecal ligation and puncture." | 5.31 | Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression was minimally affected by both anesthetics in rats with abdominal sepsis. ( Fujisawa, J; Inada, T; Kobayashi, Y; Nakao, S; Shingu, K; Taniuchi, S, 2001) |
| "Sevoflurane was used as the sole anaesthetic agent." | 5.31 | Influence of sepsis on sevoflurane minimum alveolar concentration in a porcine model. ( Allaouchiche, B; Chassard, D; Debon, R; Duflo, F; Tournadre, JP, 2001) |
| "In adults with severe sepsis and detectable plasma cell-free hemoglobin, treatment with acetaminophen within 24 hours of ICU admission may reduce oxidative injury and improve renal function." | 5.20 | Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. ( Bastarache, JA; Bernard, GR; Janz, DR; Oates, JA; Rice, TW; Roberts, LJ; Sills, G; Ware, LB; Warren, MA; Wickersham, N, 2015) |
| "To compare the effects of an intravenous infusion of propofol and the alpha-2 adrenoceptor, dexmedetomidine, on inflammatory responses and intraabdominal pressure (IAP) in severe sepsis after abdominal surgery, specifically, serum cytokine levels (interleukin [IL]-1, IL-6, and tumor necrosis factor [TNF]-alpha) and IAP." | 5.14 | Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. ( Memis, D; Sut, N; Tasdogan, M; Yuksel, M, 2009) |
| "An open, prospective study was carried out on 45 patients with multiple injuries to compare the mortality and incidence of sepsis between those given early total enteral nutrition (TEN) when sedated with propofol and historical controls who had been given total parenteral nutrition (TPN) and sedated with midazolam." | 5.07 | Long-term sedation in the ICU: enteral versus parenteral feeding. ( Bataillie, K; Baute, L; Demeyer, I, 1994) |
| "We presented a sepsis outbreak caused by Serratia marcescens from contaminated propofol to raise awareness." | 3.91 | Serratia marcescens sepsis outbreak caused by contaminated propofol. ( Aksit-Barik, S; Arda, B; Cilli, F; Gulay, Z; Kepeli, N; Nazli-Zeka, A; Ozinel, MA; Sipahi, OR; Ulusoy, S, 2019) |
| "Taken together, the present study showed that propofol can protect against sepsis-induced liver dysfunction through suppressing hepatic oxidative stress, lipid peroxidation, inflammation, and drug biotransformation and interactions in the liver." | 3.88 | Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions. ( Chen, JT; Chen, RM; Lee, YW; Lin, YW; Tsai, HC; Wu, GJ, 2018) |
| "We have shown that systemic attenuation of inflammation by the volatile anaesthetic sevoflurane did not translate into attenuated neuro-inflammation in this LPS-induced inflammation model." | 3.85 | Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study. ( Baumann, L; Beck-Schimmer, B; Booy, C; Eugster, P; Hasler, M; Restin, T; Schläpfer, M, 2017) |
| "A multicenter, retrospective, propensity-matched pilot study was conducted comparing patients with sepsis or severe sepsis who received CIV propofol for sedation to those who did not." | 3.83 | Effects of propofol on vasopressor use in patients with sepsis and severe sepsis: A pilot study. ( Boucher, AN; Jones, GM; Kimmons, LA; Marler, J; Mohrien, K; Oliphant, CS; Vandigo, JE, 2016) |
| "The aim of this study was to determine the effect of etomidate and propofol pretreatment on the expression of glucocorticoid receptor and the prognosis of sepsis." | 3.81 | Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats. ( Li, RM; Liu, N; Shen, L; Wang, C; Xiong, JY; Zhang, Y, 2015) |
| "This is the first study to assess prolonged effects of sepsis and long-term application of volatile sedatives compared to propofol on survival, cardiovascular, inflammatory and end organ parameters." | 3.81 | Propofol increases morbidity and mortality in a rat model of sepsis. ( Beck-Schimmer, B; Bonini, MG; Dull, RO; Mao, M; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE; Z'Graggen, BR, 2015) |
| "Sepsis and postoperative infection can occur as a result of unsafe practices in the administration of propofol and other injectable medications." | 3.78 | Safe injection practices for administration of propofol. ( King, CA; Ogg, M, 2012) |
| "Propofol treatment could protect kidney from sepsis-induced AKI by increasing BMP-7 expression, decreasing inflammatory cytokines and inhibiting oxidative stress." | 3.77 | Propofol increases bone morphogenetic protein-7 and decreases oxidative stress in sepsis-induced acute kidney injury. ( Chen, HW; Chou, W; Hsing, CH; Wang, JJ; Yeh, CH, 2011) |
| "To explore the effects of propofol on the outcomes of rats with sepsis." | 3.77 | Effects of propofol on the outcomes of rats with sepsis. ( Bao, HG; Li, S, 2011) |
| "We concluded that iNOS-induced NO might be involved in the manifestation of the BHF and BLF components of the SAP spectrum during endotoxemia when low-dose propofol is used, and this effect of NO is blunted when high-dose propofol is administered." | 3.75 | Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009) |
| "Propofol treatment attenuated the overproduction of NO and O2*-, thus restoring the acetylcholine-responsive NO-cGMP pathway in CLP-induced sepsis." | 3.73 | Propofol improves endothelial dysfunction and attenuates vascular superoxide production in septic rats. ( Hwang, TL; Lau, YT; Lui, PW; Yen, CH; Yu, HP, 2006) |
| "Pretreatment with propofol attenuated diaphragmatic dysfunction induced by septic peritonitis in hamsters assessed by contractile profiles and endurance capacity." | 3.71 | Propofol attenuates diaphragmatic dysfunction induced by septic peritonitis in hamsters. ( Kodama, S; Mikawa, K; Nishina, K; Obara, H, 2001) |
| "Propofol and nondepolarizing muscle relaxants are widely used for various clinical cases, including sepsis." | 3.70 | Propofol enhances a d-tubocurarine-induced twitch depression in septic rat diaphragm. ( Fujimura, N; Iwasaki, H; Nakayama, Y; Namiki, A; Narimatsu, E; Satoh, K; Sumita, S, 2000) |
| "Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness." | 2.47 | Clinical effects and lethal and forensic aspects of propofol. ( Levy, RJ, 2011) |
| "Propofol is an oil at room temperature and insoluble in aqueous solution." | 2.42 | Propofol: therapeutic indications and side-effects. ( Marik, PE, 2004) |
| "Propofol exposure was significantly higher in patients with ICUAW compared to controls (63." | 1.46 | Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure. ( Abdelmalik, PA; Rakocevic, G, 2017) |
| "An outbreak of severe sepsis in patients who underwent minor procedures in an operating theatre during two consecutive days is described and analysed in this study." | 1.36 | Outbreak of severe sepsis due to contaminated propofol: lessons to learn. ( Dorresteijn, JJ; Harbers, JB; Huisman, I; Klein, J; Muller, AE; Rietveld, AP; Roos, PJ; van Steenbergen, JE; Vos, MC, 2010) |
| " Therefore, we tested the dose-response direct cardiac effects of clinically available induction agents in an isolated septic rat heart model." | 1.35 | Cardiac effects of induction agents in the septic rat heart. ( Busse, H; Graf, BM; Lunz, D; Sinner, B; Zausig, YA; Zink, W, 2009) |
| "Propofol has inhibited the hepatic NF-kappaB activation and the pro-inflammatory cytokine response during polymicrobial sepsis in rats." | 1.35 | Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats. ( Li, JG; Liang, H; Song, XM; Wang, CY; Wang, YL; Zhang, ZZ; Zhou, Q, 2009) |
| "And it increased W/D ratio of lung, lung injury score and leukocyte count, percentage of PMN cells, concentration of albumin, thromboxane B2 and IL-8 in BALF." | 1.32 | Effects of propofol on endotoxin-induced acute lung injury in rabbit. ( Choi, JI; Kwak, SH; Park, JT, 2004) |
| "Sevoflurane was used as the sole anaesthetic agent." | 1.31 | Influence of sepsis on sevoflurane minimum alveolar concentration in a porcine model. ( Allaouchiche, B; Chassard, D; Debon, R; Duflo, F; Tournadre, JP, 2001) |
| "Sepsis was induced in rats by cecal ligation and puncture." | 1.31 | Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression was minimally affected by both anesthetics in rats with abdominal sepsis. ( Fujisawa, J; Inada, T; Kobayashi, Y; Nakao, S; Shingu, K; Taniuchi, S, 2001) |
| "Postoperative complications were more frequent during the epidemic period than before it." | 1.29 | Postoperative infections traced to contamination of an intravenous anesthetic, propofol. ( Arduino, MJ; Bennett, SN; Bland, LA; Burwen, DR; McNeil, MM; Pegues, DA; Perrotta, DM; Stroud, L; Villarino, ME; Welbel, SF, 1995) |
| " In this study, the effects of propofol in healthy and in septic sheep, and in combination with fentanyl, were analyzed and compared with nonanesthetized septic sheep." | 1.29 | The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep. ( Armstrong, C; Booke, M; Conroy, B; Hinder, F; Traber, DL; Traber, LD, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (11.36) | 18.2507 |
| 2000's | 17 (38.64) | 29.6817 |
| 2010's | 18 (40.91) | 24.3611 |
| 2020's | 4 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Moore, JPR | 3 |
| Shehabi, Y | 3 |
| Reade, MC | 3 |
| Bailey, M | 3 |
| Fraser, JF | 3 |
| Murray, L | 3 |
| Anstey, C | 3 |
| Singer, M | 3 |
| Patel, C | 1 |
| Kleinig, P | 1 |
| Bakker, M | 1 |
| Tait, P | 1 |
| Aso, S | 1 |
| Matsui, H | 1 |
| Fushimi, K | 1 |
| Yasunaga, H | 1 |
| Yamamoto, K | 1 |
| Hughes, CG | 1 |
| Mailloux, PT | 1 |
| Devlin, JW | 1 |
| Swan, JT | 1 |
| Sanders, RD | 1 |
| Anzueto, A | 1 |
| Jackson, JC | 1 |
| Hoskins, AS | 1 |
| Pun, BT | 1 |
| Orun, OM | 1 |
| Raman, R | 1 |
| Stollings, JL | 1 |
| Kiehl, AL | 1 |
| Duprey, MS | 1 |
| Bui, LN | 1 |
| O'Neal, HR | 1 |
| Snyder, A | 1 |
| Gropper, MA | 1 |
| Guntupalli, KK | 1 |
| Stashenko, GJ | 1 |
| Patel, MB | 1 |
| Brummel, NE | 1 |
| Girard, TD | 1 |
| Dittus, RS | 1 |
| Bernard, GR | 2 |
| Ely, EW | 1 |
| Pandharipande, PP | 1 |
| Beck-Schimmer, B | 2 |
| Baumann, L | 1 |
| Restin, T | 1 |
| Eugster, P | 1 |
| Hasler, M | 1 |
| Booy, C | 1 |
| Schläpfer, M | 2 |
| Wu, GJ | 2 |
| Lin, YW | 2 |
| Chuang, CY | 1 |
| Tsai, HC | 2 |
| Chen, RM | 2 |
| Chen, CY | 1 |
| Tsai, YF | 1 |
| Huang, WJ | 1 |
| Chang, SH | 1 |
| Hwang, TL | 2 |
| Zheng, G | 1 |
| Qu, H | 1 |
| Li, F | 1 |
| Ma, W | 1 |
| Yang, H | 1 |
| Lee, YW | 1 |
| Chen, JT | 1 |
| Cilli, F | 1 |
| Nazli-Zeka, A | 1 |
| Arda, B | 1 |
| Sipahi, OR | 1 |
| Aksit-Barik, S | 1 |
| Kepeli, N | 1 |
| Ozinel, MA | 1 |
| Gulay, Z | 1 |
| Ulusoy, S | 1 |
| Janz, DR | 1 |
| Bastarache, JA | 1 |
| Rice, TW | 1 |
| Warren, MA | 1 |
| Wickersham, N | 1 |
| Sills, G | 1 |
| Oates, JA | 1 |
| Roberts, LJ | 1 |
| Ware, LB | 1 |
| Piegeler, T | 1 |
| Dull, RO | 1 |
| Schwartz, DE | 1 |
| Mao, M | 1 |
| Bonini, MG | 1 |
| Z'Graggen, BR | 1 |
| Minshall, RD | 1 |
| Wang, C | 1 |
| Liu, N | 1 |
| Li, RM | 1 |
| Zhang, Y | 1 |
| Shen, L | 1 |
| Xiong, JY | 1 |
| Marler, J | 1 |
| Mohrien, K | 1 |
| Kimmons, LA | 1 |
| Vandigo, JE | 1 |
| Oliphant, CS | 1 |
| Boucher, AN | 1 |
| Jones, GM | 1 |
| Abdelmalik, PA | 1 |
| Rakocevic, G | 1 |
| Song, XM | 1 |
| Wang, YL | 1 |
| Li, JG | 1 |
| Wang, CY | 1 |
| Zhou, Q | 1 |
| Zhang, ZZ | 1 |
| Liang, H | 1 |
| Liu, YC | 1 |
| Chan, JY | 1 |
| Tsai, YC | 1 |
| Zausig, YA | 1 |
| Busse, H | 1 |
| Lunz, D | 1 |
| Sinner, B | 1 |
| Zink, W | 1 |
| Graf, BM | 2 |
| Tasdogan, M | 1 |
| Memis, D | 1 |
| Sut, N | 1 |
| Yuksel, M | 1 |
| Royse, CF | 1 |
| Klein, J | 2 |
| Huisman, I | 2 |
| Menon, AG | 1 |
| Leenders, CM | 1 |
| van Eeghem, KH | 1 |
| Vos, MG | 1 |
| Dorresteijn, JJ | 2 |
| Muller, AE | 1 |
| Roos, PJ | 1 |
| Rietveld, AP | 1 |
| Harbers, JB | 1 |
| van Steenbergen, JE | 1 |
| Vos, MC | 1 |
| Hsing, CH | 1 |
| Chou, W | 1 |
| Wang, JJ | 1 |
| Chen, HW | 1 |
| Yeh, CH | 1 |
| Levy, RJ | 1 |
| Bao, HG | 1 |
| Li, S | 1 |
| King, CA | 1 |
| Ogg, M | 1 |
| Kwak, SH | 1 |
| Choi, JI | 1 |
| Park, JT | 1 |
| Bopp, C | 1 |
| Plachky, J | 1 |
| Hofer, S | 1 |
| Weigand, MA | 1 |
| Marik, PE | 2 |
| Yu, HP | 1 |
| Lui, PW | 1 |
| Yen, CH | 1 |
| Lau, YT | 1 |
| De Waele, JJ | 1 |
| Hoste, E | 1 |
| Bollen, PJ | 1 |
| Nielsen, BJ | 1 |
| Toft, P | 1 |
| Bennett, SN | 1 |
| McNeil, MM | 1 |
| Bland, LA | 1 |
| Arduino, MJ | 1 |
| Villarino, ME | 1 |
| Perrotta, DM | 1 |
| Burwen, DR | 1 |
| Welbel, SF | 1 |
| Pegues, DA | 1 |
| Stroud, L | 1 |
| Booke, M | 1 |
| Armstrong, C | 1 |
| Hinder, F | 1 |
| Conroy, B | 1 |
| Traber, LD | 1 |
| Traber, DL | 1 |
| Murphy, PG | 1 |
| Ogilvy, AJ | 1 |
| Whiteley, SM | 1 |
| Demeyer, I | 1 |
| Bataillie, K | 1 |
| Baute, L | 1 |
| Sakuragi, T | 1 |
| Yanagisawa, K | 1 |
| Shirai, Y | 1 |
| Dan, K | 1 |
| Nakayama, Y | 1 |
| Narimatsu, E | 1 |
| Sumita, S | 1 |
| Fujimura, N | 1 |
| Satoh, K | 1 |
| Iwasaki, H | 1 |
| Namiki, A | 1 |
| Mehta, U | 1 |
| Gunston, GD | 1 |
| O'Connor, N | 1 |
| Inada, T | 1 |
| Taniuchi, S | 1 |
| Shingu, K | 1 |
| Kobayashi, Y | 1 |
| Fujisawa, J | 1 |
| Nakao, S | 1 |
| Mikawa, K | 1 |
| Nishina, K | 1 |
| Kodama, S | 1 |
| Obara, H | 1 |
| Allaouchiche, B | 1 |
| Duflo, F | 1 |
| Tournadre, JP | 1 |
| Debon, R | 1 |
| Chassard, D | 1 |
| Zaloga, GP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-06-30 | Recruiting | ||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-04-28 | Recruiting | ||
| Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis[NCT01739933] | Phase 3 | 438 participants (Actual) | Interventional | 2013-05-15 | Completed | ||
| Impact of Dexmedetomidine Supplemented Analgesia on Long-term Survival in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012971] | 1,500 participants (Actual) | Interventional | 2017-01-06 | Active, not recruiting | |||
| Does LOW Dose DEXmedetomidine After Cardiopulmonary Bypass Separation Decrease the Incidence of DELirium: A Double-blind Randomized Placebo-controlled Study (LOWDEXDEL Study)[NCT03388541] | Phase 4 | 420 participants (Actual) | Interventional | 2018-01-17 | Completed | ||
| Impact of Dexmedetomidine Supplemented Analgesia on Incidence of Delirium in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012984] | 1,500 participants (Actual) | Interventional | 2017-01-06 | Completed | |||
| An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894] | 124 participants (Actual) | Observational | 2016-09-07 | Completed | |||
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| A Multi-center, Double-blind, Randomized, Controlled Study to Determine the Efficacy and Safety of a New Formulation of Acetylcysteine Injection[NCT01118663] | Phase 3 | 17 participants (Actual) | Interventional | 2010-09-30 | Terminated | ||
| Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection[NCT03134612] | Phase 2 | 104 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Evaluation of Bacterial and Fungal Contamination During Propofol Continuous Infusion in Patients Undergoing General Anesthesia[NCT00757458] | 652 participants (Anticipated) | Interventional | 2008-12-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Telephone Interview for Cognitive Status is a standardized test of cognitive functioning that monitors changes in cognitive functioning over time. The TICS-T consists 11 items including wordlist memory, orientation, attention, repetition, conceptual knowledge and nonverbal praxis. Age-adjusted total scores on the TICS-T range from 0 to 100 with a mean of 50+/-10; lower scores indicate worse cognition, and a score of 35 or less indicates cognitive impairment. (NCT01739933)
Timeframe: 6 months after randomization
| Intervention | score on a scale (Median) |
|---|---|
| Dexmedetomidine | 39 |
| Propofol | 38 |
That sedation of mechanically ventilated severely septic patients with an alpha2 agonist (dexmedetomidine) rather than a GABAergic agent (propofol) will improve 90-day survival of ICU patients. (NCT01739933)
Timeframe: 1 through 90 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine | 81 |
| Propofol | 82 |
The analysis of DCFDs will be conducted using Intention-to-Treat (ITT) population, defined as all patients who were randomized and received study drug. We chose a 14 day evaluation period for delirium, because it represents the best balance of gaining valuable clinical information, while maximizing resource utilization, given the average study drug infusion to be 7 days and maximum duration to be 14 days. Thus our follow-up period will cover 7 additional days of delirium monitoring after the study drug is stopped in the majority of our patients. (NCT01739933)
Timeframe: 14 days
| Intervention | days (Median) |
|---|---|
| Dexmedetomidine | 8 |
| Propofol | 7.5 |
Ventilator-free days (VFDs), i.e., days alive and free of mechanical ventilation (MV) at 28 days. This endpoint has been used by the National Heart, Lung, and Blood Institute (NHLBI) ARDSNet in numerous critical care trials examining ICU populations. (NCT01739933)
Timeframe: 28 Days
| Intervention | days (Median) |
|---|---|
| Dexmedetomidine | 20.9 |
| Propofol | 19.9 |
Data analysis was conducted on the subjects enrolled in the study prior to study termination. Because the study was terminated prematurely due to lack of enrollment, there was an insufficient sample size to conduct an efficacy analysis. (NCT01118663)
Timeframe: 1 hour
| Intervention | participants (Number) |
|---|---|
| Acetadote Without EDTA | 0 |
| Acetadote | 1 |
(NCT01118663)
Timeframe: 21-42 hours
| Intervention | Number of Events (Number) |
|---|---|
| Acetadote Without EDTA | 13 |
| Acetadote | 14 |
3 reviews available for propofol and Sepsis
| Article | Year |
|---|---|
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed | 2019 |
Clinical effects and lethal and forensic aspects of propofol.
Topics: Accidents; Acidosis; Acute Kidney Injury; Bacteremia; Bradycardia; Drug Overdose; Dyslipidemias; For | 2011 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
5 trials available for propofol and Sepsis
| Article | Year |
|---|---|
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; | 2022 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans | 2021 |
Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cell-Free System; Creatinine; Critical Illness; Doub | 2015 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Hum | 2009 |
Long-term sedation in the ICU: enteral versus parenteral feeding.
Topics: Adult; APACHE; Enteral Nutrition; Female; Humans; Injury Severity Score; Male; Midazolam; Multiple T | 1994 |
36 other studies available for propofol and Sepsis
| Article | Year |
|---|---|
Dexmedetomidine and Mortality From Sepsis Requiring Mechanical Ventilation: A Japanese Nationwide Retrospective Cohort Study.
Topics: Adult; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Japan; Propofol; Resp | 2021 |
Risk of propofol use for sedation in COVID-19 patient.
Topics: Animals; Betacoronavirus; Conscious Sedation; Coronavirus Infections; COVID-19; Humans; Hypnotics an | 2020 |
Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Inflammation; Inflammation Mediators; Li | 2017 |
Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF-κB-mediated iNOS and IL-6 gene expressions.
Topics: Actins; Animals; Cecal Diseases; Down-Regulation; Gene Expression Regulation; Hepatitis; Hypnotics a | 2018 |
Propofol inhibits endogenous formyl peptide-induced neutrophil activation and alleviates lung injury.
Topics: Acute Lung Injury; Animals; Cell Movement; Chemotactic Factors; Gene Expression Regulation; Humans; | 2018 |
Propofol attenuates sepsis-induced acute kidney injury by regulating miR-290-5p/CCL-2 signaling pathway.
Topics: Acute Kidney Injury; Animals; Blotting, Western; Chemokine CCL2; Flow Cytometry; Male; Mice; MicroRN | 2018 |
Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions.
Topics: Animals; Drug Interactions; Inflammation; Interleukin-1beta; Interleukin-4; Lipid Peroxidation; Live | 2018 |
Serratia marcescens sepsis outbreak caused by contaminated propofol.
Topics: Cross Infection; Disease Outbreaks; Drug Contamination; Electrophoresis, Gel, Pulsed-Field; Female; | 2019 |
Propofol increases morbidity and mortality in a rat model of sepsis.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Male; Propofol; Rats; Rats, Wistar; Respi | 2015 |
Effects of propofol and etomidate pretreatment on glucocorticoid receptor expression following induction of sepsis in rats.
Topics: Adrenal Cortex; Animals; Etomidate; Female; Inflammation; Propofol; Rats; Rats, Sprague-Dawley; Rece | 2015 |
Effects of propofol on vasopressor use in patients with sepsis and severe sepsis: A pilot study.
Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Female; Hospital Mortality; Humans; Hypnotics and Se | 2016 |
Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure.
Topics: Adult; Aged; Cohort Studies; Critical Illness; Electronic Health Records; Female; Humans; Hypnotics | 2017 |
Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats.
Topics: Animals; Cecum; Cytokines; Disease Models, Animal; Hemodynamics; Hepatic Duct, Common; Histocytochem | 2009 |
Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Is | 2009 |
Cardiac effects of induction agents in the septic rat heart.
Topics: Analgesics; Anesthetics, Intravenous; Animals; Cardiomyopathies; Dose-Response Relationship, Drug; G | 2009 |
Anaesthesia in septic patients: good preparation and making the right choice?
Topics: Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Choice Be | 2009 |
[Postoperative infection due to contaminated propofol].
Topics: Anesthetics, Intravenous; Cross Infection; Disease Outbreaks; Drug Contamination; Humans; Klebsiella | 2010 |
Outbreak of severe sepsis due to contaminated propofol: lessons to learn.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Child; Child, Preschool; Cohor | 2010 |
Propofol increases bone morphogenetic protein-7 and decreases oxidative stress in sepsis-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Blotting, Western; Bone Morphogenetic Protein 7; Cecum; Cel | 2011 |
Effects of propofol on the outcomes of rats with sepsis.
Topics: Anesthetics, Intravenous; Animals; Cecum; Disease Models, Animal; Heart; HMGB1 Protein; Injections, | 2011 |
Safe injection practices for administration of propofol.
Topics: Cross Infection; Disease Outbreaks; Drug Contamination; Equipment Reuse; Humans; Infection Control; | 2012 |
Effects of propofol on endotoxin-induced acute lung injury in rabbit.
Topics: Acute Disease; Albumins; Anesthetics, Intravenous; Animals; Blood Platelets; Blood Pressure; Broncho | 2004 |
[Anesthesia and intensive care medicine--status report. XIIIth International Symposium on Anesthesia in Heidelberg, March 19-21, 2004].
Topics: Anesthesia; Anesthesia, Conduction; Anesthesiology; Anesthetics, Intravenous; Blood Transfusion; Car | 2004 |
Propofol improves endothelial dysfunction and attenuates vascular superoxide production in septic rats.
Topics: Animals; Cyclic GMP; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Hypnotics and Se | 2006 |
Propofol infusion syndrome in a patient with sepsis.
Topics: Abdominal Abscess; Acidosis; Adult; Anesthetics, Intravenous; Drainage; Heart Failure; Humans; Hyper | 2006 |
Influence of endotoxin-induced sepsis on the requirements of propofol-fentanyl infusion rate in pigs.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Endotoxins; Fentanyl; Infusions, Intrave | 2007 |
Postoperative infections traced to contamination of an intravenous anesthetic, propofol.
Topics: Adult; Aged; Aged, 80 and over; Anesthesiology; Asepsis; Bacteria; Candida albicans; Case-Control St | 1995 |
The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep.
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Fentanyl; Hemodynamics; Kidney; Oxygen; Pr | 1996 |
The effect of propofol on the neutrophil respiratory burst.
Topics: Adult; Anesthetics, Intravenous; Fat Emulsions, Intravenous; Humans; Luminescent Measurements; N-For | 1996 |
Growth of Escherichia coli in propofol, lidocaine, and mixtures of propofol and lidocaine.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Anti-Bacterial Agents; Colony Count, Microbial; Drug C | 1999 |
Propofol enhances a d-tubocurarine-induced twitch depression in septic rat diaphragm.
Topics: Anesthetics, Intravenous; Animals; Diaphragm; Male; Muscle Contraction; Neuromuscular Nondepolarizin | 2000 |
Serious consequences to misuse of propofol anaesthetic.
Topics: Anesthetics, Intravenous; Equipment Contamination; Humans; Klebsiella Infections; Klebsiella pneumon | 2000 |
Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression was minimally affected by both anesthetics in rats with abdominal sepsis.
Topics: Anesthetics, Intravenous; Animals; Hydrogen Peroxide; Integrin alphaXbeta2; Macrophage-1 Antigen; Ma | 2001 |
Propofol attenuates diaphragmatic dysfunction induced by septic peritonitis in hamsters.
Topics: Animals; Cricetinae; Diaphragm; Dose-Response Relationship, Drug; Endotoxins; Immunohistochemistry; | 2001 |
Influence of sepsis on sevoflurane minimum alveolar concentration in a porcine model.
Topics: Analgesics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Ketamine; Methyl Ethers; Mod | 2001 |
Therapeutic sedation: has its time come?
Topics: Animals; Critical Care; Cytokines; Humans; Hypnotics and Sedatives; Nitric Oxide; Propofol; Rats; Se | 2002 |