Page last updated: 2024-11-03

propofol and Respiratory Distress Syndrome

propofol has been researched along with Respiratory Distress Syndrome in 32 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Respiratory Distress Syndrome: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.

Research Excerpts

ExcerptRelevanceReference
"The incidence and risk factors for propofol-associated hypertriglyceridemia (HTG) in patients receiving extracorporeal membrane oxygenation (ECMO) have not been evaluated."8.31Propofol-Associated Hypertriglyceridemia in Adults With Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation. ( Erkanli, A; Kim, H; Ohman, K; Parish, A; Rackley, CR; Schultheis, J; Stallworth, S, 2023)
"A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine."8.12Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome. ( Andermatt, R; Bartussek, J; Buehler, PK; Camen, G; David, S; Erlebach, R; Hofmaenner, DA; Jüngst, C; Müllhaupt, B; Schuepbach, RA; Wendel-Garcia, PD, 2022)
"The goal of this study was to confirm whether or not sevoflurane is more effective than propofol in ameliorating the inflammatory response in an animal model of acute respiratory distress syndrome."7.79Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study. ( Aguilar, G; Belda, FJ; Ferrando, C; Moreno, J; Piqueras, L; Soro, M, 2013)
"To explore whether propofol plays a protective role in kidney injury during acute respiratory distress syndrome (ARDS) by affecting the expression of Gq/11 protein."7.73[Influence of propofol on Gq/11 protein in kidney during acute respiratory distress syndrome]. ( Abasi, K; Jialili, A; Li, XJ; Zhang, L, 2006)
"Propofol is an antiinflammatory and immunosuppressive drug."5.33Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005)
"A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine."4.12Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome. ( Andermatt, R; Bartussek, J; Buehler, PK; Camen, G; David, S; Erlebach, R; Hofmaenner, DA; Jüngst, C; Müllhaupt, B; Schuepbach, RA; Wendel-Garcia, PD, 2022)
"The goal of this study was to confirm whether or not sevoflurane is more effective than propofol in ameliorating the inflammatory response in an animal model of acute respiratory distress syndrome."3.79Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study. ( Aguilar, G; Belda, FJ; Ferrando, C; Moreno, J; Piqueras, L; Soro, M, 2013)
"We conclude that the severity of remote lung injury was not different between sevoflurane and propofol anaesthesia in this porcine model of severe lower-body ischaemia and reperfusion injury."3.74Lung injury following thoracic aortic occlusion: comparison of sevoflurane and propofol anaesthesia. ( Annecke, T; Bittmann, I; Conzen, PF; Hilberath, JM; Kahr, S; Kemming, GI; Krombach, F; Kubitz, JC; Langer, K; Rehm, M, 2008)
"High-dose propofol infusion for sedation of patients in the intensive care unit can result in rhabdomyolysis, acute renal failure, metabolic acidosis, hyperkalemia, ventricular arrhythmia, hyperthermia, and death."3.73A lethal complication of propofol. ( Chavez, VM; Haake, RJ; Hayat, SA; Suen, HC, 2006)
"To explore whether propofol plays a protective role in kidney injury during acute respiratory distress syndrome (ARDS) by affecting the expression of Gq/11 protein."3.73[Influence of propofol on Gq/11 protein in kidney during acute respiratory distress syndrome]. ( Abasi, K; Jialili, A; Li, XJ; Zhang, L, 2006)
"In acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), recruitment manoeuvres (RMs) are used frequently."2.76Prolonged moderate pressure recruitment manoeuvre results in lower optimal positive end-expiratory pressure and plateau pressure. ( Lindgren, S; Lowhagen, K; Lundin, S; Odenstedt, H; Stenqvist, O, 2011)
"Propofol was administered by intermittent intravenous bolus titration by trained practice nurses under supervision of the gastroenterologist."2.73Propofol sedation in outpatient colonoscopy by trained practice nurses supervised by the gastroenterologist: a prospective evaluation of over 3000 cases. ( Sieg, A, 2007)
"Propofol was administered by continuous infusion at an initial rate of 5 microg/kg per min and titrated as needed."2.69Effects of propofol containing EDTA on mineral metabolism in medical ICU patients with pulmonary dysfunction. ( Abraham, E; Hall, JB; Papadakos, PJ; Tharratt, RS; Williams, GJ, 2000)
"Propofol was infused at 1."1.91Unusual case of propofol-related infusion syndrome complicating severe COVID-19 ARDS. ( Babu, VK; Garcia-Fernandez, A; Perez Del Nogal, G; Rojas, P, 2023)
"Propofol exposure may increase the risk of ICUAW in septic patients."1.46Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure. ( Abdelmalik, PA; Rakocevic, G, 2017)
"The complications, including acute renal failure, disseminated intravascular coagulation, and acute respiratory distress syndrome were also treated without any obvious organ damage."1.39Continuous veno-venous hemofiltration for massive rhabdomyolysis after malignant hyperthermia: report of 2 cases. ( Fang, S; Jiang, H; Xu, H; Zhu, Y, 2013)
"Treatment with propofol abrogated or reversed the oleic acid-induced changes."1.35Protective effects of propofol on acute lung injury induced by oleic acid in conscious rats. ( Chen, HI; Hsieh, NK; Kao, SJ; Su, CF, 2008)
"Propofol is an antiinflammatory and immunosuppressive drug."1.33Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005)
"Our patient was newly diagnosed to have autoimmune hepatitis that may have predisposed her to toxicity from corticosteroids and neuromuscular-blocking agents, but she recovered her strength completely."1.33Critical care myopathy in a child. ( Newman, AJ; Singer, NG, 2005)
"The propofol of 10 mg/kg was administered intraperitoneally in the propofol group (60 rats) twice a day for four consecutive days one hour after the rats were intoxicated while the normal saline of the same amount as propofol in the propofol group was administered in the intoxication group (60 rats) one hour after the rats were intoxicated."1.33[Propofol protecting rats from paraquat induced lung injury]. ( Hu, JL; Huang, HM; Li, XH; Shi, HW; Su, JL; Tian, YP, 2006)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (9.38)18.2507
2000's17 (53.13)29.6817
2010's6 (18.75)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Cortellazzo Wiel, L1
Monasta, L1
Pascolo, P1
Servidio, AG1
Levantino, L1
Fasoli, S1
Saccari, A1
Cozzi, G1
Barbi, E1
Wendel-Garcia, PD1
Erlebach, R1
Hofmaenner, DA1
Camen, G1
Schuepbach, RA1
Jüngst, C1
Müllhaupt, B1
Bartussek, J1
Buehler, PK1
Andermatt, R1
David, S1
Babu, VK1
Rojas, P1
Perez Del Nogal, G1
Garcia-Fernandez, A1
Stallworth, S1
Ohman, K1
Schultheis, J1
Parish, A1
Erkanli, A1
Kim, H1
Rackley, CR1
Guay, CS1
Bean, CD1
Kwon, O1
Brown, EN1
Payen, JF1
Chanques, G1
Futier, E1
Velly, L1
Jaber, S1
Constantin, JM1
Fang, S1
Xu, H1
Zhu, Y1
Jiang, H1
Ferrando, C1
Aguilar, G1
Piqueras, L1
Soro, M1
Moreno, J1
Belda, FJ1
Eikermann, M1
Vidal Melo, MF1
Abdelmalik, PA1
Rakocevic, G1
Haitsma, JJ1
Lachmann, B1
Papadakos, PJ2
Lowhagen, K1
Lindgren, S1
Odenstedt, H1
Stenqvist, O1
Lundin, S1
Clouzeau, B1
Bui, HN1
Guilhon, E1
Grenouillet-Delacre, M1
Leger, MS1
Saghi, T1
Pillot, J1
Filloux, B1
Coz, S1
Boyer, A1
Vargas, F1
Gruson, D1
Hilbert, G1
Ziser, A1
Strickland, RA1
Murray, MJ1
Gao, J2
Zeng, BX1
Zhou, LJ1
Yuan, SY1
Zeng, B1
Zhou, L1
Varpula, T1
Valta, P1
Niemi, R1
Takkunen, O1
Hynynen, M1
Pettilä, VV1
Takao, Y1
Mikawa, K1
Nishina, K1
Obara, H1
Kahn, JM1
Andersson, L1
Karir, V1
Polissar, NL1
Neff, MJ1
Rubenfeld, GD1
Newman, AJ1
Singer, NG1
Suen, HC1
Haake, RJ1
Chavez, VM1
Hayat, SA1
Shi, HW1
Hu, JL1
Tian, YP1
Huang, HM1
Li, XH1
Su, JL1
Jialili, A1
Abasi, K1
Zhang, L1
Li, XJ1
Chondrogiannis, KD1
Siontis, GC1
Koulouras, VP1
Lekka, ME1
Nakos, G1
Sieg, A1
Chen, HI1
Hsieh, NK1
Kao, SJ1
Su, CF1
Yu, HP1
Lau, YT1
Annecke, T1
Kubitz, JC1
Langer, K1
Hilberath, JM1
Kahr, S1
Krombach, F1
Bittmann, I1
Rehm, M1
Kemming, GI1
Conzen, PF1
el-Ebiary, M1
Torres, A1
Ramirez, J1
Xaubet, A1
Rodriguez-Roisin, R1
Valente, JF1
Anderson, GL1
Branson, RD1
Johnson, DJ1
Davis, K1
Porembka, DT1
Cammarano, WB1
Pittet, JF1
Weitz, S1
Schlobohm, RM1
Marks, JD1
Abraham, E1
Tharratt, RS1
Hall, JB1
Williams, GJ1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
AnaConDa-therapy in COVID-19 Patients[NCT05586126]42 participants (Actual)Observational2020-10-01Terminated (stopped due to Concerns about possible association between drug and increased ICU mortality)
Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane[NCT05680545]10 participants (Anticipated)Interventional2024-07-01Not yet recruiting
A Randomized Pilot Clinical Trial of the Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction of Sevoflurane in Patient's Whit ARDS Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)[NCT04998253]Early Phase 124 participants (Actual)Interventional2020-10-01Completed
Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)[NCT00000579]Phase 30 participants Interventional1994-09-30Completed
Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19[NCT05336656]353 participants (Actual)Observational2022-01-01Completed
Investigation of Changes in the Levels of Exhaled NO and Eosinophil Blood Count in Patients Undergoing Thyroidectomy by Two Different Methods of General Anesthesia Maintenance[NCT02065635]60 participants (Actual)Interventional2014-05-31Completed
Opioids Withdrawal Syndrome in Critically Ill Patients: a Multicenter Prospective Cohort Study[NCT02318290]54 participants (Actual)Observational2015-01-31Completed
Opioid Withdrawal Symptoms in Critically Ill Patients[NCT03374722]55 participants (Actual)Observational2018-01-01Completed
Signs and Symptoms of Opioid-associated Iatrogenic Withdrawal in Critically Ill Adults[NCT03435614]29 participants (Actual)Observational2018-02-26Completed
Assessing Current Analgesia and Sedation Weaning Practices in Adult Critically Ill Patients[NCT04422808]2,437 participants (Actual)Observational2021-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Description of Signs and Symptoms of OIWS in Patients Who Scored Positive for Withdrawal Syndrome (OIWS) According to Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Criteria

"Percentage of daily assessments associated with each of the following signs and symptoms experienced by patients with and without OIWS (Restlessness (Richmond Agitation-Sedation scale = 1), Agitation (RASS > 1), Anxiety, Hallucinations, Insomnia/sleep disturbance (< 4 hours of continuous sleep), Mydriasis (Pupil diameter > 2 mm) and systolic blood pressure (SBP) > 140 mmHg. These assessments were performed once daily.~Note that for the group of patients experiencing IWS, the data on signs and symptoms are limited to the assessment on the day that patients experienced OIWS.~The signs and symptoms presented (Restlessness; Agitation; Anxiety, Hallucinations, Insomnia/sleep disturbance; mydriasis; SBP > 140) were selected based on a > 15 % absolute difference between both groups which was judged to be clinically significant." (NCT03435614)
Timeframe: From first day of opioid dose reduction until transfer out of Intensive care unit (ICU) or a maximum of 14 days, including one further assessment post-ICU transfer

,
Interventionpercentage of assessments (Number)
Restlessness (RASS = 1)Agitation (RASS > 1)AnxietyHallucinationsInsomnia/Sleep disturbance (< 4 hours of continuous sleep)Mydriasis (pupil size > 2mm)Systolic Blood Pressure (SBP) > 140 mmHg
IWS Negative13.64.930.611.221.477.853
IWS Positive28.628.657.128.666.710085.7

Reviews

1 review available for propofol and Respiratory Distress Syndrome

ArticleYear
Sedation for critically ill patients with COVID-19: Which specificities? One size does not fit all.
    Anaesthesia, critical care & pain medicine, 2020, Volume: 39, Issue:3

    Topics: Analgesics, Opioid; Betacoronavirus; Coronavirus Infections; COVID-19; Critical Illness; Deep Sedati

2020

Trials

5 trials available for propofol and Respiratory Distress Syndrome

ArticleYear
Prolonged moderate pressure recruitment manoeuvre results in lower optimal positive end-expiratory pressure and plateau pressure.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:2

    Topics: Acute Lung Injury; Aged; Anesthetics, Intravenous; Cardiac Output; Cross-Over Studies; Electric Impe

2011
Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:6

    Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Cardiac Output; Continuous Positive Airway Pressure

2004
Low tidal volume ventilation does not increase sedation use in patients with acute lung injury.
    Critical care medicine, 2005, Volume: 33, Issue:4

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Dose-Response Relationship, Drug; Female; Humans; Hypnot

2005
Low tidal volume ventilation does not increase sedation use in patients with acute lung injury.
    Critical care medicine, 2005, Volume: 33, Issue:4

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Dose-Response Relationship, Drug; Female; Humans; Hypnot

2005
Low tidal volume ventilation does not increase sedation use in patients with acute lung injury.
    Critical care medicine, 2005, Volume: 33, Issue:4

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Dose-Response Relationship, Drug; Female; Humans; Hypnot

2005
Low tidal volume ventilation does not increase sedation use in patients with acute lung injury.
    Critical care medicine, 2005, Volume: 33, Issue:4

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Dose-Response Relationship, Drug; Female; Humans; Hypnot

2005
Propofol sedation in outpatient colonoscopy by trained practice nurses supervised by the gastroenterologist: a prospective evaluation of over 3000 cases.
    Zeitschrift fur Gastroenterologie, 2007, Volume: 45, Issue:8

    Topics: Ambulatory Care; Cohort Studies; Colonoscopy; Female; Gastroenterology; Germany; Humans; Hypnotics a

2007
Effects of propofol containing EDTA on mineral metabolism in medical ICU patients with pulmonary dysfunction.
    Intensive care medicine, 2000, Volume: 26 Suppl 4

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anesthetics, Intravenous; Calcium; Chelating A

2000

Other Studies

26 other studies available for propofol and Respiratory Distress Syndrome

ArticleYear
Recovery characteristics and parental satisfaction in pediatric procedural sedation.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:3

    Topics: Child; Conscious Sedation; Dexmedetomidine; Hallucinations; Humans; Hypnotics and Sedatives; Ketamin

2022
Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome.
    Critical care (London, England), 2022, 05-23, Volume: 26, Issue:1

    Topics: Bilirubin; COVID-19; Critical Illness; Humans; Hypnotics and Sedatives; Ketamine; Liver; Propofol; R

2022
Unusual case of propofol-related infusion syndrome complicating severe COVID-19 ARDS.
    BMJ case reports, 2023, Feb-07, Volume: 16, Issue:2

    Topics: Acidosis; Aged; COVID-19; Humans; Hyperlipidemias; Hypertriglyceridemia; Male; Propofol; Propofol In

2023
Propofol-Associated Hypertriglyceridemia in Adults With Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation.
    ASAIO journal (American Society for Artificial Internal Organs : 1992), 2023, 09-01, Volume: 69, Issue:9

    Topics: Adult; Cohort Studies; Extracorporeal Membrane Oxygenation; Humans; Hypertriglyceridemia; Propofol;

2023
Recovery From Acute Respiratory Distress Syndrome Is Associated With Increasing Alpha Power in the Frontal Electroencephalogram During Propofol Sedation: A Case Report.
    A&A practice, 2023, Jul-01, Volume: 17, Issue:7

    Topics: Adult; Anesthesia; Electroencephalography; Humans; Hypnotics and Sedatives; Male; Propofol; Respirat

2023
Continuous veno-venous hemofiltration for massive rhabdomyolysis after malignant hyperthermia: report of 2 cases.
    Anesthesia progress, 2013,Spring, Volume: 60, Issue:1

    Topics: Acute Kidney Injury; Adolescent; Adult; Anesthesia, Dental; Anesthesia, General; Anesthetics, Intrav

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
    European journal of anaesthesiology, 2013, Volume: 30, Issue:8

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He

2013
Therapeutic range of spontaneous breathing during mechanical ventilation.
    Anesthesiology, 2014, Volume: 120, Issue:3

    Topics: Anesthetics, Intravenous; Animals; Diaphragm; Lung Injury; Male; Muscular Atrophy; Propofol; Respira

2014
Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2017, Volume: 44, Issue:3

    Topics: Adult; Aged; Cohort Studies; Critical Illness; Electronic Health Records; Female; Humans; Hypnotics

2017
Additives in intravenous anesthesia modulate pulmonary inflammation in a model of LPS-induced respiratory distress.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:2

    Topics: Acute Lung Injury; Adjuvants, Anesthesia; Anesthesia, Intravenous; Animals; Bronchoalveolar Lavage F

2009
Fiberoptic bronchoscopy under noninvasive ventilation and propofol target-controlled infusion in hypoxemic patients.
    Intensive care medicine, 2011, Volume: 37, Issue:12

    Topics: Adult; Aged; Anesthetics, Intravenous; Bronchoalveolar Lavage; Bronchoscopy; Drug Delivery Systems;

2011
Propofol does not induce pulmonary dysfunction in stressed endotoxic pigs receiving Intralipid.
    Critical care medicine, 2003, Volume: 31, Issue:7

    Topics: Animals; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous; Hemodynamics; Lung; Male; Pro

2003
Protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats.
    British journal of anaesthesia, 2004, Volume: 92, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Blotting, Western; Bronchoalveolar Lavage Fluid; Drug Administrat

2004
The protective effects of early treatment with propofol on endotoxin-induced acute lung injury in rats.
    Middle East journal of anaesthesiology, 2003, Volume: 17, Issue:3

    Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Blotting, Western; Hemodynamics; Lipopolysa

2003
Attenuation of acute lung injury with propofol in endotoxemia.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:3

    Topics: Animals; Blood Pressure; Endotoxemia; Lung; Male; Nitric Oxide Synthase; Peroxynitrous Acid; Propofo

2005
Critical care myopathy in a child.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2005, Volume: 11, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Creatine Kinase; Critical Care; Female; Hepatitis, Autoimmune;

2005
A lethal complication of propofol.
    Asian cardiovascular & thoracic annals, 2006, Volume: 14, Issue:1

    Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Creatine Kinase; Dose-Response Relat

2006
[Propofol protecting rats from paraquat induced lung injury].
    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2006, Volume: 24, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Hydroxyproline; Lung; Male; Malondialdehyde; Paraquat; Propof

2006
[Influence of propofol on Gq/11 protein in kidney during acute respiratory distress syndrome].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2006, Volume: 18, Issue:12

    Topics: Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gq-G11; Kidney; Male; Propofol;

2006
Acute lung injury probably associated with infusion of propofol emulsion.
    Anaesthesia, 2007, Volume: 62, Issue:8

    Topics: Cerebral Hemorrhage; Critical Care; Female; Humans; Hypnotics and Sedatives; Middle Aged; Propofol;

2007
Protective effects of propofol on acute lung injury induced by oleic acid in conscious rats.
    Critical care medicine, 2008, Volume: 36, Issue:4

    Topics: Animals; Disease Models, Animal; Hemodynamics; Hypnotics and Sedatives; Male; Oleic Acid; Propofol;

2008
Since when did sedatives start to save lives?
    Critical care medicine, 2008, Volume: 36, Issue:4

    Topics: Animals; Cytokines; Humans; Hypnotics and Sedatives; Propofol; Respiratory Distress Syndrome

2008
Lung injury following thoracic aortic occlusion: comparison of sevoflurane and propofol anaesthesia.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:7

    Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Arterial Oc

2008
Lipid deposition during the long-term infusion of propofol.
    Critical care medicine, 1995, Volume: 23, Issue:11

    Topics: Aged; Embolism, Fat; Enteral Nutrition; Fatal Outcome; Humans; Hypnotics and Sedatives; Infusions, I

1995
Disadvantages of prolonged propofol sedation in the critical care unit.
    Critical care medicine, 1994, Volume: 22, Issue:4

    Topics: Adult; Critical Care; Female; Humans; Intensive Care Units; Postoperative Complications; Propofol; R

1994
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998
Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients.
    Critical care medicine, 1998, Volume: 26, Issue:4

    Topics: Acute Disease; Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Dose-Response

1998