propofol has been researched along with Postoperative Cognitive Complications in 15 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Postoperative Cognitive Complications: COGNITIVE IMPAIRMENT or functional decline after a surgical procedure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 8.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| " We found that high-dose propofol anesthesia significantly alleviated spatial memory loss." | 7.91 | High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton. ( An, J; Cao, L; Cope, D; Eastwood, D; Fang, Q; Lin, S; Ma, J; Qian, X; Williams, J; Yuan, Z, 2019) |
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 4.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| " We found that high-dose propofol anesthesia significantly alleviated spatial memory loss." | 3.91 | High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton. ( An, J; Cao, L; Cope, D; Eastwood, D; Fang, Q; Lin, S; Ma, J; Qian, X; Williams, J; Yuan, Z, 2019) |
| "Increased incidence of postoperative cognitive dysfunction (POCD) is observed in elderly patients underwent intravenous anesthesia (TIVA) with endotracheal intubation." | 3.30 | Effects of total intravenous anesthesia with etomidate and propofol on postoperative cognitive dysfunction. ( Li, W; Zhi, Y, 2023) |
| "If remimazolam has associated anterograde amnesia similar to benzodiazepines, it will have a positive effect on preventing psychological trauma." | 3.01 | The effect of remimazolam on postoperative memory retention and delayed regeneration in breast surgery patients: Rationale and design of an exploratory, randomized, open, propofol-controlled, single-center clinical trial: A study protocol. ( Funakoshi, K; Higashi, M; Nakamura, T; Nobukuni, K; Shirozu, K; Sumie, M; Yamaura, K, 2021) |
| "All randomized controlled trials (RCTs) on reducing propofol dosage under closed-loop systems were collected, and the literature was screened out, the abstracts and full texts were carefully read, and the references were tracked, data extraction and quality evaluation were conducted on the included research, and the RevMan5." | 2.72 | Bispectral index monitoring of the clinical effects of propofol closed-loop target-controlled infusion: Systematic review and meta-analysis of randomized controlled trials. ( Chen, P; Song, Z; Wang, D; Zhang, C, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 14 (93.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pang, QY | 1 |
| Duan, LP | 1 |
| Jiang, Y | 1 |
| Liu, HL | 1 |
| Lian, F | 1 |
| Cao, C | 1 |
| Deng, F | 1 |
| Liu, C | 1 |
| Zhou, Z | 1 |
| Shirozu, K | 1 |
| Nobukuni, K | 1 |
| Funakoshi, K | 1 |
| Nakamura, T | 1 |
| Sumie, M | 1 |
| Higashi, M | 1 |
| Yamaura, K | 1 |
| Liu, P | 1 |
| Zhao, S | 1 |
| Qiao, H | 1 |
| Li, T | 1 |
| Mi, W | 1 |
| Xu, Z | 1 |
| Xue, X | 1 |
| Li, S | 2 |
| Zhou, Y | 2 |
| Hu, H | 2 |
| Wang, X | 2 |
| Xu, J | 2 |
| Bai, C | 2 |
| Yuan, J | 2 |
| Zhang, D | 2 |
| Zhi, Y | 1 |
| Li, W | 2 |
| Ma, J | 1 |
| Williams, J | 1 |
| Eastwood, D | 1 |
| Lin, S | 1 |
| Qian, X | 1 |
| Fang, Q | 1 |
| Cope, D | 1 |
| Yuan, Z | 1 |
| Cao, L | 1 |
| An, J | 1 |
| Su, W | 1 |
| Xie, M | 1 |
| Li, Y | 2 |
| Gong, X | 1 |
| Li, J | 1 |
| Guo, L | 1 |
| Lin, F | 1 |
| Dai, H | 1 |
| Du, X | 1 |
| Yu, M | 1 |
| Zhang, J | 1 |
| Huang, H | 1 |
| Ge, W | 1 |
| Tao, G | 1 |
| Pan, L | 1 |
| Tian, L | 1 |
| Luan, H | 1 |
| Zhu, P | 1 |
| Zhang, Z | 1 |
| Bao, H | 1 |
| Mahr, N | 1 |
| Bouhake, Y | 1 |
| Chopard, G | 1 |
| Liu, N | 1 |
| Boichut, N | 1 |
| Chazot, T | 1 |
| Claveau, M | 1 |
| Vettoretti, L | 1 |
| Tio, G | 1 |
| Pili-Floury, S | 1 |
| Samain, E | 1 |
| Besch, G | 1 |
| Shen, YX | 1 |
| Chen, YP | 1 |
| Zang, HC | 1 |
| Shao, G | 1 |
| Chen, D | 1 |
| Wang, H | 1 |
| Wang, Z | 1 |
| Song, F | 1 |
| Li, H | 1 |
| Ling, L | 1 |
| Shen, Z | 1 |
| Hu, C | 1 |
| Peng, J | 1 |
| Xing, W | 1 |
| Pan, J | 1 |
| Liang, H | 1 |
| Zhou, Q | 1 |
| Cai, J | 1 |
| He, Z | 1 |
| Peng, S | 1 |
| Zeng, W | 1 |
| Zuo, Z | 1 |
| Wang, D | 1 |
| Song, Z | 1 |
| Zhang, C | 1 |
| Chen, P | 1 |
| Zhao, X | 1 |
| Huang, ZQ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| One-year Mortality According to the Method of Total Intravenous Anesthesia. A Prospective, Randomized and Multicenter Study[NCT01198639] | 2,044 participants (Actual) | Interventional | 2010-09-13 | Completed | |||
| Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers[NCT05601856] | 104 participants (Anticipated) | Observational | 2022-12-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for propofol and Postoperative Cognitive Complications
| Article | Year |
|---|---|
Effects of inhalation and propofol anaesthesia on postoperative cognitive dysfunction in elderly noncardiac surgical patients: A systematic review and meta-analysis.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Humans; Mental Status and | 2021 |
Does propofol definitely improve postoperative cognitive dysfunction?-a review of propofol-related cognitive impairment.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Cognitive Dysfunction; Humans; Postoperative Cogn | 2022 |
Bispectral index monitoring of the clinical effects of propofol closed-loop target-controlled infusion: Systematic review and meta-analysis of randomized controlled trials.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Consciousness Monitors; Dose-Response Relationshi | 2021 |
6 trials available for propofol and Postoperative Cognitive Complications
| Article | Year |
|---|---|
The effect of remimazolam on postoperative memory retention and delayed regeneration in breast surgery patients: Rationale and design of an exploratory, randomized, open, propofol-controlled, single-center clinical trial: A study protocol.
Topics: Amnesia, Anterograde; Benzodiazepines; Breast Neoplasms; Female; Humans; Postoperative Cognitive Com | 2021 |
Effects of total intravenous anesthesia with etomidate and propofol on postoperative cognitive dysfunction.
Topics: Aged; Anesthesia, General; Anesthesia, Intravenous; Etomidate; Humans; Hydrocortisone; Interleukin-6 | 2023 |
Impact of Sevoflurane Versus Propofol Anesthesia on Post-Operative Cognitive Dysfunction in Elderly Cancer Patients: A Double-Blinded Randomized Controlled Trial.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Double-Blind Method; Female; Follow-Up Stud | 2020 |
A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy.
Topics: Adult; Colonoscopy; Deep Sedation; Double-Blind Method; Drug Therapy, Combination; Female; Humans; H | 2020 |
Postoperative Neurocognitive Disorders After Closed-Loop Versus Manual Target Controlled-Infusion of Propofol and Remifentanil in Patients Undergoing Elective Major Noncardiac Surgery: The Randomized Controlled Postoperative Cognitive Dysfunction-Electroe
Topics: Aged; Anesthesia, Closed-Circuit; Anesthesia, Intravenous; Anesthetics, Intravenous; Elective Surgic | 2021 |
Intravenous versus Volatile Anesthetic Effects on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Abdominal Surgery.
Topics: Abdomen; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; China; Double-Blind Me | 2021 |
6 other studies available for propofol and Postoperative Cognitive Complications
| Article | Year |
|---|---|
Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats.
Topics: Animals; Cognitive Dysfunction; Humans; Inflammation; Isoflurane; MicroRNAs; Postoperative Cognitive | 2022 |
SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Inflammation; Lipopolysaccharides; Mice; Mice, In | 2022 |
SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Inflammation; Lipopolysaccharides; Mice; Mice, In | 2022 |
SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Inflammation; Lipopolysaccharides; Mice; Mice, In | 2022 |
SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Inflammation; Lipopolysaccharides; Mice; Mice, In | 2022 |
High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cytoskeleton; Hippocampus; Male; Maze Learning; Memor | 2019 |
Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway.
Topics: Anesthetics; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Fas Ligand Protein; fas R | 2020 |
Evaluation of the efficiency of propofol versus isoflurane anesthesia interventions in treating elderly patients with postoperative cognitive dysfunction: A protocol for systematic review and meta-analysis.
Topics: Aged; Aged, 80 and over; Anesthetics; Female; Humans; Isoflurane; Male; Meta-Analysis as Topic; Midd | 2020 |
Does propofol ameliorate occurrence of postoperative cognitive dysfunction after general anaesthesia? A protocol of systematic review.
Topics: Anesthesia, General; China; Humans; Meta-Analysis as Topic; Postoperative Cognitive Complications; P | 2021 |