propofol has been researched along with Pain in 669 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the incidence and severity of injection pain caused by microemulsion propofol and lipid emulsion propofol in relation to plasma bradykinin generation and aqueous free propofol concentrations." | 10.24 | Pain on injection with microemulsion propofol. ( Jung, JA; Ki, KH; Lee, DH; Lee, SH; Noh, GJ; Park, DY; Sim, JY, 2009) |
| "To study the incidence of pain upon injection of 1% propofol (Propofol-Lipuro 1%, B." | 10.21 | [Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides]. ( Ayuso, MA; Fernández, J; Gomar, C; Luis, M; Sala, X, 2004) |
| "Propofol is commonly used to induce general anesthesia; however, the pain caused during propofol injection is a disadvantage." | 9.69 | Deep breathing alleviates propofol-induced pain: a prospective, randomized, single-blind study. ( Hamada, T; Mori, T; Nishikawa, K; Tanaka, K; Yoshizumi, Y, 2023) |
| "Etomidate in combination with oxycodone for painless gastroscopic operation in the elderly is a safe and effective anesthetic strategy." | 9.69 | Safety and efficacy of etomidate in combination with oxycodone in painless gastroscopic procedures in the elderly: A prospective randomized controlled trial study. ( Li, YP; Zhou, Y, 2023) |
| "Regardless of the positive attributes of propofol, it is frequently associated with pain on injection." | 9.69 | Prevention of pain on injection of propofol using ice gel pack versus pre-treatment with lignocaine: a randomized controlled trial. ( Chauhan, R; Karki, Y; Luthra, A; Meena, SC; Sarna, R; Singh, N; Thappa, P, 2023) |
| "8% for the difference between the groups, which met the predesigned criteria of > - 8%, confirming the non-inferiority of anesthesia/sedation produced by HSK3486 compared to propofol." | 9.51 | Efficacy and Safety of HSK3486 for Anesthesia/Sedation in Patients Undergoing Fiberoptic Bronchoscopy: A Multicenter, Double-Blind, Propofol-Controlled, Randomized, Phase 3 Study. ( Guo, Q; Li, Y; Luo, Z; Ouyang, W; Shangguan, W; Tu, H; Wang, X; Wang, Y; Wei, X; Wu, H; Zhang, X; Zhu, Z; Zou, X, 2022) |
| "The primary outcome was the efficacy of ondansetron compared to lidocaine and placebo for the reduction of propofol injection pain." | 9.51 | A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study. ( Chaofan, S; Kosem, R; Plansangkate, P; Tanasansuttiporn, J; Termthong, S; Wasinwong, W, 2022) |
| "The study was aimed to compare the efficacy and safety of different sedation protocols of dexmedetomidine-remifentanil and propofol-remifentanil for percutaneous closure of atrial septal defects (ASD) under transthoracic echocardiography (TTE) guidance." | 9.51 | Comparison of the efficacy and safety of sedation protocols with the use of dexmedetomidine-remifentanil and propofol-remifentanil during percutaneous closure of atrial septal defects: a randomized clinical trial. ( Chen, XL; Huang, WH; Zhang, GC; Zheng, YH, 2022) |
| "To investigate the comparison and clinical value of ciprofol and propofol for painless gastroenteroscopy anesthesia in terms of intraoperative adverse reactions, operation, resuscitation, and satisfaction of patients." | 9.51 | Comparison and Clinical Value of Ciprofol and Propofol in Intraoperative Adverse Reactions, Operation, Resuscitation, and Satisfaction of Patients under Painless Gastroenteroscopy Anesthesia. ( Chen, X; Guo, P; Liu, Z; Yang, L; Yu, D, 2022) |
| "Propofol-induced injection pain (PIP) is a well-known problem in general anesthesia." | 9.41 | Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial. ( Cao, H; Gong, X; Guan, X; Huang, X; Jiao, Z; Lan, H; Lin, C; Liu, S; Tan, Y; Xu, B, 2021) |
| "To determine the median effective dose (ED50) of prophylactic intravenous lidocaine for the prevention of propofol medium-chain triglyceride/long-chain triglyceride (MCT/LCT) emulsion injection pain." | 9.41 | Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight. ( Ma, R; Shan, Q; Sui, W; Tan, C; Tian, S; Xing, Z; Zhang, D; Zhang, Z; Zhou, W, 2021) |
| "The intensities of injection pain resulting from the use of long- and medium-chain triglyceride (LCT/MCT) propofol and conventional LCT propofol during esophagogastroduodenoscopy (EGD) have yet to be compared." | 9.41 | Pain Intensity at Injection Site during Esophagogastroduodenoscopy Using Long- and Medium-Chain versus Long-Chain Triglyceride Propofol: A Randomized Controlled Double-Blind Study. ( Cho, KB; Kim, ES; Lee, JS; Lee, JY; Lee, YJ; Park, KS, 2021) |
| "Pain is a common side effect of intravenous injection of propofol." | 9.41 | The Effect of Vibration on Pain During Intravenous Injection of Propofol: A Randomized Controlled Trial. ( Choice, C; Greige, N; Hwang, LK; Larios-Valencia, J; Nash, DW; Pothula, A; Yedlin, A, 2021) |
| "To assess the factors associated with adenoma detection in propofol-sedated patients." | 9.30 | Factors Associated With Adenoma Detection in Propofol-sedated Patients. ( Dong, T; Hsieh, YH; Hu, CT; Jia, H; Koo, M; Leung, FW; Pan, Y; Tseng, CW; Zhang, L, 2019) |
| "Remifentanil was a μ-agonist, with a rapid onset, a powerful narcotic analgesic activity and a fast nonspecific esterases hydrolyzation and theoretically an ideal opioid for percutaneous dilatational tracheostomy (PDT)." | 9.30 | The use of remifentanil in critically ill patients undergoing percutaneous dilatational tracheostomy: A prospective randomized-controlled trial. ( Chang, SY; Feng, M; Liu, G; Sun, RQ; Wang, HL; Xu, DQ; Xu, YM, 2019) |
| "To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection." | 9.30 | Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial. ( Jongjidpranitarn, M; Nimmaanrat, S; Oofuvong, M; Prathep, S, 2019) |
| "Lidocaine alleviates propofol injection pain." | 9.27 | Intravenous Lidocaine Alleviates the Pain of Propofol Injection by Local Anesthetic and Central Analgesic Effects. ( Cai, J; Hei, Z; Liang, L; Luo, C; Xing, J; Zhou, S, 2018) |
| "Current analgesic strategies for propofol injection pain may cause adverse reactions during electroconvulsive therapy (ECT), such as shortening seizure duration." | 9.27 | Effect of dexmedetomidine for attenuation of propofol injection pain in electroconvulsive therapy: a randomized controlled study. ( Chen, CJ; Hei, ZQ; Li, X; Pan, JR; Tan, F; Xing, JB; Zhou, SL; Zhu, QQ, 2018) |
| "In this study, the aim was to investigate the effect of hyoscine N-butylbromide (HnBB) pretreatment on pain during propofol injection." | 9.27 | Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study. ( Aydoğan, E; Sargın, M; Uluer, MS, 2018) |
| "Pain on injection is a limitation with propofol use." | 9.27 | Evaluation of efficacy of Valsalva maneuver for attenuating propofol injection pain: a prospective, randomized, single blind, placebo controlled study. ( Agarwal, A; Dixit, A; Gautam, S; Khuba, S; Kumar, S; Yadav, M, 2018) |
| "Propofol causes injection pain." | 9.24 | Preventive effect of a vapocoolant spray on propofol-induced pain: a prospective, double-blind, randomized study. ( Kim, DH; Lee, MY; Moon, YE, 2017) |
| " Propofol with opioids has been recommended for gastroscopy sedation but the effects on cough reflex suppression remain unclear." | 9.24 | Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial. ( Cao, YZ; Lu, X; Xia, J; Xie, J; Yin, N; Yuan, J, 2017) |
| "Propofol is associated with pain during injection, which is stressful to patients." | 9.24 | Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study. ( Jeon, Y; Kim, S; Kwon, T; Lee, M; Park, K, 2017) |
| "Administration of 300 mg MgSO4 plus 40 mg lidocaine reduces propofol injection pain very well." | 9.22 | Magnesium Sulfate Plus Lidocaine Reduces Propofol Injection Pain: A Double-blind, Randomized Study. ( Lin, W; Sun, J; Wang, W; Zhou, J; Zhou, R, 2016) |
| "Injection pain of propofol remains a common clinical problem." | 9.22 | Efficacy of different fluids preload on propofol injection pain: A randomized, controlled, double-blinded study. ( Lin, Y; Liu, Z; Luo, TY; Yuan, SY, 2016) |
| "Lidocaine reduces pain that occurs upon the intravenous injection of propofol." | 9.22 | Comparison of the effects of lidocaine pre-administration and local warming of the intravenous access site on propofol injection pain: Randomized, double-blind controlled trial. ( Jeong, M; Yoon, H, 2016) |
| "To determine the most effective time interval between remifentanil and propofol (TimeRP) for the prevention of propofol injection pain in association with remifentanil dosage." | 9.22 | Impact of time interval between remifentanil and propofol on propofol injection pain. ( Chung, S; Jeong, S; Lee, HJ; Lee, SE; Lee, SH, 2016) |
| "Pretreatment with oral pregabalin 150 mg and intravenous lidocaine 40 mg with venous occlusion equally reduced pain from propofol injection." | 9.22 | Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection: A double-blind, randomized clinical consort study. ( Choi, E; Jeon, Y; Kim, D, 2016) |
| "The incidence of propofol injection pain is high in children, but no methods have been found to suppress it completely." | 9.20 | Preemptive dexmedetomidine to prevent propofol injection pain in children. ( Dong, C; Lu, Y; Yu, J; Zhang, Y, 2015) |
| "In this double-blind, placebo-controlled, randomized trial, the combination of intravenous magnesium sulfate and lidocaine offered no additional benefit for the relief of propofol injection pain compared to intravenous lidocaine alone." | 9.20 | Magnesium sulfate with lidocaine for preventing propofol injection pain: a randomized, double-blind, placebo-controlled trial. ( Galgon, RE; Groth, J; Heier, J; Schroeder, KM; Strube, P; Wang, S, 2015) |
| " The objective was to evaluate EMLA (eutectic mixture of local anesthetics) cream as a pain reliever in conjunction with propofol in the setting of routine lumbar punctures." | 9.20 | Topical analgesia treats pain and decreases propofol use during lumbar punctures in a randomized pediatric leukemia trial. ( Bazzell, S; Roe, DJ; Saboda, K; Whitlow, PG; Wilson, C, 2015) |
| "We aimed to compare the effectiveness of esmolol 1 mg/kg and lidocaine 1 mg/kg for injection pain and for the prevention of rocuronium-induced withdrawal response." | 9.20 | Effects of pretreatment with esmolol and lidocaine on injection pain and rocuronium-induced withdrawal response. ( Akinci, M; Bumin Aydin, G; Ergil, J; Gürel, A; Kavak Akelma, F; Özkan, D, 2015) |
| "To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine." | 9.19 | Cisatracurium pretreatment with tourniquet reduces propofol injection pain: a double-blind randomized controlled trial. ( Kim, YH; Lim, CH; Namgung, J, 2014) |
| "5 mg/kg lidocaine with venous occlusion is recommended to prevent pain following injection of lipid emulsion propofol." | 9.19 | Intravenous lidocaine pretreatment with venous occlusion for reducing microemulsion propofol induced pain: comparison of three doses of lidocaine. ( Chae, YJ; Chang, HS; Joe, HB; Kim, DH; Kim, JA, 2014) |
| "Propofol injection pain is a common and unsolved anaesthesia problem." | 9.19 | Influence of polyvinyl chloride infusion extension tube on propofol injection pain: a randomised controlled study. ( Jia, Y; Lei, W; Shen, Y; Wu, Q; Zhang, N, 2014) |
| "One of the concerns in the use of propofol is the pain on injection of the drug." | 9.19 | [Effect of concentration on counting numbers on pain induced by injection of propofol]. ( Fujimoto, K; Kurahashi, K; Toh, M, 2014) |
| "The study was designed to investigate postoperative nausea and vomiting (PONV) in low- and high-dose remifentanil regimens for total intravenous anaesthesia (TIVA) in adult female patients with American Society of Anaesthesiologists physical status classification I undergoing local breast excision." | 9.19 | Total intravenous anaesthesia with high-dose remifentanil does not aggravate postoperative nausea and vomiting and pain, compared with low-dose remifentanil: a double-blind and randomized trial. ( Cho, MJ; Kim, SH; Oh, CS; Yang, JH; Yi, HR; Yoon, TG, 2014) |
| "The incidence of propofol-induced pain was significantly higher in the control group (39%) than in the other three groups (17% in the cooling group, 16% in the lidocaine group and 8% in the lidocaine plus cooling group)." | 9.19 | [Effectiveness of local cooling and lidocaine administration for prevention of pain upon injection of propofol]. ( Fujinaka, W; Takatori, M; Takubo, I; Terada, N, 2014) |
| "To examine whether dexmedetomidine reduces the injection pain of propofol and rocuronium and to investigate whether the decrease in injection pain is associated with the known sedative action of dexmedetomidine." | 9.19 | Dexmedetomidine reduces pain associated with rocuronium injection without causing a decrease in BIS values: a dose-response study. ( Baek, J; Joo, J; Lee, J, 2014) |
| "To evaluate the pain on injection of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy." | 9.19 | Comparing the pain of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy. ( Bao, Y; Shi, D; Zhang, L, 2014) |
| "The incidence of propofol injection pain during induction of general anesthesia varies from 28% to 90%." | 9.19 | Dexmedetomidine pretreatment alleviates propofol injection pain. ( He, L; He, T; Liu, L; Xu, JM; Zhu, R, 2014) |
| "Propofol causes considerable pain upon injection, although different methods and propofol formulations have been used to decrease this pain." | 9.17 | Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain. ( Akgün Salman, E; Akpek, E; Arslan, G; Titiz, L, 2013) |
| "The aim of this study was to determine whether pretreatment with alkalinised lignocaine reduced the incidence and severity of pain during propofol injection." | 9.17 | Effect of alkalinisation of lignocaine for propofol injection pain: a prospective, randomised, double-blind study. ( Aydogan, MS; Begec, Z; Colak, C; Erdogan, MA; Ozgul, U; Sanli, M, 2013) |
| "Ketamine can completely eliminate pain associated with propofol injection." | 9.17 | An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study. ( Wang, M; Wang, Q; Wang, WS; Yu, YY, 2013) |
| "This prospective, double-blind, placebo-controlled study was designed to determine the efficacy of nitrous oxide (N(2)O) in alleviating the pain that followed sequential injection of propofol and rocuronium." | 9.17 | Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection. ( Kim, CH; Kim, E; Kim, HK; Kim, HY; Kwon, JY; Lee, DW, 2013) |
| "The goal of this study was to evaluate the effect of different methods of tourniquet application and lidocaine administration on MP injection pain." | 9.17 | Reducing the pain of microemulsion propofol injections: a double-blind, randomized study of three methods of tourniquet and lidocaine. ( Kim, HZ; Kim, K; Kim, NS; Kong, MH; Lee, DK; Lee, IO; Lim, BG; Sung Kim, Y, 2013) |
| "The lidocaine-ketamine combination is most effective for decreasing the pain on propofol injection." | 9.17 | A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013) |
| " This study aimed to measure the incidence of propofol injection pain and evaluate the effect of lidocaine on pain caused during sedative upper GI endoscopic examinations." | 9.16 | Incidence of propofol injection pain and effect of lidocaine pretreatment during upper gastrointestinal endoscopy. ( Cho, KB; Chung, WJ; Hwang, JS; Jang, BK; Kim, ES; Kim, TY; Kwon, JS; Lee, JE; Park, KS; Park, WY, 2012) |
| "A significantly higher proportion of patients in the placebo group (83 %) experienced pain compared to the lidocaine and combination groups (43 and 7 %, respectively; both, P < 0." | 9.16 | Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine. ( Jeon, Y, 2012) |
| "To assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups." | 9.16 | Ondansetron pretreatment reduces pain on injection of propofol. ( Maleki, A; Rostami, G; Zahedi, H, 2012) |
| "To evaluate the efficacy of ketamine in preventing propofol injection pain in children." | 9.16 | Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine. ( Bao, SM; Guo, Y; Meng, LX; Zhang, LH; Zhao, GY, 2012) |
| "kg(-1) and lidocaine 20 mg mixture significantly reduced propofol pain when compared with control group." | 9.16 | Prevention of propofol injection pain in children: a comparison of pretreatment with tramadol and propofol-lidocaine mixture. ( Borazan, H; Et, T; Kececioglu, A; Otelcioglu, S; Sahin, O; Uluer, MS, 2012) |
| "02 mg, % 2 lidocaine 40 mg, metoclopramide 10 mg, and ketamine 100 microg/kg yields propofol induced pain 38%, 76%, 76%, and 58% respectively." | 9.16 | The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "Subclinical doses of pentazocine can be used in the painless egg retrieval, but the dose of propofol should be increased to reduce the body activity during the operation." | 9.15 | [Application of subclinical doses of pentazocine and propofol in painless vaginal egg retrieval]. ( Ding, H; Gu, MN; Liang, FG; Shi, YS; Zhou, W, 2011) |
| "The lidocaine/flurbiprofen axetil combination, compared with lidocaine 40 mg or flurbiprofen 50 mg, effectively reduces pain during the injection of propofol." | 9.15 | Efficacy of the lidocaine/flurbiprofen axetil combination for reducing pain during the injection of propofol. ( Fujii, Y; Itakura, M, 2011) |
| "Pain frequency was 90% in the saline group, whereas the frequencies were significantly lower in the lidocaine and methylene blue groups (26." | 9.15 | Pain on injection of propofol: a comparison of methylene blue and lidocaine. ( Akinci, SB; Aypar, Ü; Salman, AE; Salman, MA; Saricaoglu, F, 2011) |
| "Pretreatment with combination of small-dose ephedrine and lidocaine could reduce the incidence and intensity of propofol-induced pain and also result in more stable hemodynamic profile, but however, the combination of two drugs failed to work better in further reduction of pain." | 9.15 | The effect of combined ephedrine and lidocaine pretreatment on pain and hemodynamic changes due to propofol injection. ( Kayalha, H; Khezri, MB, 2011) |
| "The addition of 3% sevoflurane at the time of preoxygenation for 1 min along with routine use of lidocaine-tourniquet completely prevented pain upon propofol injection, whereas sevoflurane by itself provided similar analgesia to premixed lidocaine with propofol." | 9.15 | Sevoflurane to alleviate pain on propofol injection. ( Ali, MS; DeSousa, K, 2011) |
| " Pain on injection was compared between propofol in cyclodextrin and propofol in lipid using subject and observer assessments of pain rated at several different time points." | 9.15 | Propofol in a modified cyclodextrin formulation: first human study of dose-response with emphasis on injection pain. ( Egan, TD; Pace, NL; Shimode, N; Wallentine, CB, 2011) |
| "Rapid injection was less painful than after pretreatment with lidocaine 0." | 9.15 | Rapid injection of propofol reduces vascular pain and facilitates Laryngeal Mask Airway insertion. ( Inomata, S; Shimizu, T; Tanaka, M, 2011) |
| "The intravenous injection of microemulsion propofol to induce anaesthesia causes more intense and frequent pain than lipid emulsion propofol." | 9.15 | Reduction of microemulsion propofol-induced injection pain via target-controlled remifentanil infusion. ( Chae, YJ; Cho, HB; Kim, SM; Min, SK; Park, SK; Won, YJ, 2011) |
| "A common drawback of propofol is pain on injection and lignocaine is commonly mixed with propofol to reduce the incidence and severity of this pain." | 9.14 | Prevention of propofol pain: a comparative study. ( Jayaraman, L; Sethi, M; Sethi, N; Sharma, S; Sood, J, 2009) |
| "The aim of this study was to compare the effectiveness of these 3 different techniques of flurbiprofen axetil administration in reducing pain on injection of propofol." | 9.14 | Pretreatment with flurbiprofen axetil, flurbiprofen axetil preceded by venous occlusion, and a mixture of flurbiprofen axetil and propofol in reducing pain on injection of propofol in adult Japanese surgical patients: a prospective, randomized, double-bli ( Fujii, Y; Itakura, M, 2009) |
| "Our study demonstrated that the combination treatment of two different analgesic modalities, alfentanil and lidocaine, could prevent the moderate and severe pain on propofol injection, and reduce the incidence of mild pain compared with each drug alone." | 9.14 | Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone. ( Kim, JS; Kim, JY; Kwak, HJ; Min, SK, 2009) |
| "We conducted a prospective randomized study to assess the effects of preceding lidocaine on the incidence and intensity of propofol-induced pain." | 9.14 | [Effects of the injection method of lidocaine on preventing injection pain during anesthesia induction by target controlled infusion with propofol]. ( Kajiyama, S; Okada, Y; Osawa, Y, 2009) |
| "To investigate the alleviation effect of vein pretreatment and granisetron/lidocaine combination on propofol injection-induced pain." | 9.14 | [Effects of granisetron/lidocaine combination on propofol injection-induced pain: a double-blind randomized clinical trial]. ( Lin, XM; Ma, YS; Zhou, J, 2009) |
| "5 mg kg(-1) for prevention of propofol induced pain." | 9.14 | Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol. ( Borazan, H; Erdem, TB; Kececioglu, M; Otelcioglu, S, 2010) |
| "The aim of this study was to compare the efficacy of intravenous pretreatment with fentanyl 50 microg, fentanyl 100 microg, and lidocaine 40 mg, preceded by venous occlusion, for reducing pain on injection of propofol in adult Japanese surgical patients." | 9.14 | A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients. ( Fujii, Y; Itakura, M, 2009) |
| "On the basis of a small number of case studies, IV propofol has been advocated for the treatment of chronic daily headache (CDH)." | 9.14 | The effect of single-dose propofol injection on pain and quality of life in chronic daily headache: a randomized, double-blind, controlled trial. ( Dick, BD; Gray, DP; Jamieson-Lega, KI; Rashiq, S; Simmonds, MK; Sobolev, IA; Stewart, BJ, 2009) |
| "Administration of ketamine 100 microg x kg(-1) immediately before propofol injection is a safe and effective method in preventing propofol injection pain." | 9.14 | Prevention of propofol injection pain with small-dose ketamine. ( Nikooseresht, M; Seifrabie, M; Zahedi, H, 2009) |
| " Each of the four propofol solutions was administered 88 times; of patients receiving Baxter propofol+saline, 74 (84%) had pain; when mixed with 2% lidocaine 45 (50." | 9.14 | Pain on injection from propofol may be avoided by changing its formulation. ( Alcover, J; Aldrete, JA; Johnson, SC; Montpetit, FH; Otero, P; Parietti, A; Quiroga, D; Torrieri, A, 2010) |
| "5 mg kg(-1) ketamine reduced the incidence and intensity of propofol injection pain, whereas 1." | 9.14 | Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M; Kimura, T; Taniguchi, S; Tojo, T, 2010) |
| "This prospective, double-blind and randomized study is designed to determine the effect of menstrual cycle on the injection pain of propofol." | 9.14 | Effect of menstrual cycle on the injection pain due to propofol. ( Ayoğlu, H; Başaran, M; Erdoğan, G; Hanci, V; Okyay, RD; Turan, IO; Yilmaz, M; Yurtlu, S, 2010) |
| "To investigate the effect of parecoxib pretreatment with venous occlusion on propofol injection pain." | 9.14 | Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study. ( Bala, I; Ghai, B; Makkar, JK; Wig, J, 2010) |
| "In this prospective, randomized, double-blind, controlled trial, our primary objective was to assess the effect of a 3 : 1 mixture of propofol and thiopental in reducing pain on injection in children." | 9.14 | The effect of a 3 : 1 volume mixture of propofol 1% and thiopental 2.5% in reducing the pain on injection of propofol in children. ( Ajala, AM; Blackwelder, B; Fahringer, DL; Goodwin, SR; Gurgis, FS; Warde, MK; Ye, G, 2010) |
| "Injection pain during propofol administration can be particularly distressing in children." | 9.14 | Does the newer preparation of propofol, an emulsion of medium/long chain triglycerides cause less injection pain in children when premixed with lignocaine? ( Krishna, HM; Nittala, A; Varghese, E, 2010) |
| "During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)." | 9.14 | Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010) |
| "The use of propofol often results in pain upon injection." | 9.14 | Propofol injection pain: is it still an issue? The effect of premedication. ( Adam, S; Dedic, A; Gommers, D; Van Bommel, J, 2010) |
| "To compare the efficacy of 2% lidocaine "timing" on alleviation of pain upon induction using propofol or etomidate." | 9.14 | Does lidocaine more effectively prevent pain upon induction with propofol or etomidate when given preemptively than when mixed with the drug? ( Brock, MF; Grace, BE; Groban, L; Hillegass, G; Houle, TT; Morley, B, 2010) |
| "Pain on injection limits the use of propofol in children." | 9.13 | Avoiding propofol injection pain in children: a prospective, randomized, double-blinded, placebo-controlled study. ( Boufroukh, D; Bringuier, S; Capdevila, X; Dadure, C; Hocquet, AF; Lubrano, JF; Raux, O; Rochette, A, 2008) |
| "The overall incidence of pain on injection was 31/133 (23%) in the propofol-MCT/LCT plus lidocaine group vs." | 9.13 | Does addition of lidocaine to medium- and long-chain triglyceride propofol emulsions significantly reduce pain on injection? ( Jamjamrat, G; Kosittanasan, S; Krobbuaban, B; Kumkeaw, S; Siriwan, D; Tanomsat, M; Thanetses, K, 2008) |
| "To study the effect of the venous occlusion duration using lidocaine on the incidence and severity of propofol induced pain." | 9.13 | Duration of venous occlusion with lidocaine for preventing propofol induced pain. ( Abu-Ali, HM; Al-Ghanem, SA; Ammari, BA; Badran, IZ; Daradkeh, SS; Massad, IM, 2008) |
| " With respect to pain intensity, mean pain score was significantly less in the combination group than in the lidocaine or dexamethasone groups (P<0." | 9.13 | Efficacy of combination intravenous lidocaine and dexamethasone on propofol injection pain: a randomized, double-blind, prospective study in adult Korean surgical patients. ( Ha, J; Jeon, Y; Kim, Y; Kwak, KH, 2008) |
| "We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro." | 9.13 | Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine. ( Ahmad, N; Balan, S; Zanariah, Y, 2008) |
| " acetaminophen seems to be effective in attenuating pain during i." | 9.13 | Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain. ( Arun, O; Canbay, O; Celebi, N; Karagöz, AH; Ozgen, S; Saricaoğlu, F, 2008) |
| "Propofol produces anaesthesia with rapid recovery but also causes pain or discomfort on injection." | 9.13 | Prevention of propofol-induced injection pain by sufentanil: a placebo-controlled comparison with remifentanil. ( Honarmand, A; Safavi, M, 2008) |
| "The aim of this study was to compare the efficacy of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients." | 9.13 | Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study. ( Fujii, Y; Itakura, M, 2008) |
| "A research was performed to review the effect of pharmacological interventions to control the propofol injection pain." | 9.12 | Pharmacological control of pain during propofol injection: a systematic review and meta-analysis. ( Bakhtiari, E; Gharavi Fard, M; Mousavi, SH, 2021) |
| "Incidence and intensity of pain on intravenous injection of propofol were assessed with emulsion of long-chain/medium-chain triglycerides (LCT/MCT, 50: 50) and only long-chain triglycerides (LCT, 100) in patients undergoing different elective surgical interventions in this prospective, randomized, cross over and double-blinded study." | 9.12 | [The injection pain of propofol with different emulsion]. ( Kinoshita, M; Morioka, N; Ozaki, M; Takada, M, 2006) |
| "A basal infusion of remifentanil plus remifentanil patient controlled analgesia and target controlled infusion of propofol were adequate but not optimal techniques for sedation/analgesia for radio frequency treatment of atrial flutter." | 9.12 | Remifentanil versus propofol for radio frequency treatment of atrial flutter. ( Arnulf, JJ; Balarac, N; Lena, P; Mariottini, CJ; Martin, R; Mihoubi, A, 2006) |
| "Propofol is a widely used intravenous anesthetic although its injection pain is a common and unpleasant problem." | 9.12 | Propofol formulated with long-/medium-chain triglycerides reduces the pain of injection by target controlled infusion. ( Andoh, T; Miyazaki, H; Suzuki, H; Yamada, Y, 2006) |
| "To evaluate the effects of clonidine and ephedrine on propofol-induced pain and on hemodynamic changes during the induction sequence." | 9.12 | Clonidine-ephedrine combination reduces pain on injection of propofol and blunts hemodynamic stress responses during the induction sequence. ( Fukushima, H; Furuya, A; Ishiyama, T; Kashimoto, S; Kumazawa, T; Oguchi, T, 2006) |
| "Previous studies found that lidocaine addition to propofol long-chain triglyceride was associated with a lower incidence of injection pain than medium-chain triglyceride/long-chain triglyceride formulation, but the incidence was still high (31-40%)." | 9.12 | Preventing pain during injection of propofol: effects of a new emulsion with lidocaine addition. ( Bachmann-Mennenga, B; Boedeker, RH; Heesen, M; Mann, M; Mühlenbruch, B; Ohlmer, A, 2007) |
| "Of the 4 methods studied, the optimal method to decrease the incidence and intensity of pain resulting from propofol injection is to inject lidocaine while applying venous occlusion for 60 seconds prior to administering propofol." | 9.12 | Venous occlusion with lidocaine for preventing propofol induced pain. A prospective double-blind randomized study. ( Abu-Ali, HM; Abu-Halaweh, SA; Badran, IZ; Massad, IM, 2006) |
| "Propofol is associated with a high incidence of injection pain in children, even if given together with lidocaine." | 9.12 | Etomidate-Lipuro is associated with considerably less injection pain in children compared with propofol with added lidocaine. ( Eksborg, S; Lönnqvist, PA; Nyman, Y; Palm, C; Von Hofsten, K, 2006) |
| "This study was undertaken to examine the influence of age on flurbiprofen axetil requirements for the treatment of propofol-induced pain on injection in Japanese adult surgical patients." | 9.12 | Influence of age on flurbiprofen axetil requirements for preventing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, vehicle-controlled, parallel-group, dose-ranging study. ( Fujii, Y; Nakayama, M, 2006) |
| "We examined the effect of lidocaine pretreatment before propofol administration on the incidence of transient motor disturbances and on propofol requirements for anesthesia induction in infants and children undergoing repeated painful diagnostic and therapeutic hematological procedures." | 9.12 | Lidocaine pretreatment for the prevention of propofol-induced transient motor disturbances in children during anesthesia induction: a randomized controlled trial in children undergoing invasive hematologic procedures. ( Annino, L; Bilotta, F; Favaro, R; Ferri, F; Rosa, G; Soriano, SG, 2006) |
| "Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection." | 9.12 | Small-dose ketamine reduces the pain of propofol injection. ( Cho, SJ; Ham, KD; Hwang, JH; Kim, YK; Koo, SW, 2006) |
| "To evaluate the influence of aging on lidocaine requirements for propofol-induced pain on injection." | 9.12 | Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "Propofol has a high incidence of pain on injection, particularly when a vein on the back of hand is used." | 9.12 | Prevention of pain on injection of propofol: a comparison of remifentanil with alfentanil in children. ( Al-Mujadi, H; Al-Qattan, AR; Batra, YK; Marzouk, HM; Petrova Ivanova, M; Rahman Al-Refai, A, 2007) |
| "Pain on injection is still a major problem with propofol; metoclopramide effectively decreases this pain." | 9.12 | Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "Pain on injection of propofol in children has been reported to be as high as 30-80%." | 9.12 | Effect of a 0.5% dilution of propofol on pain on injection during induction of anesthesia in children. ( Boulaadass, S; Gräf, G; Mencke, T; Molter, GP; Silomon, M; Soltész, S, 2007) |
| "Previous injection of diphenhydramine with venous occlusion can be considered as an alternative to lidocaine for reducing the prevalence of pain caused by injection of propofol into peripheral veins." | 9.12 | Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study. ( Apiliogullari, B; Apiliogullari, S; Balasar, M; Duman, A; Keles, B; Yilmaz, H, 2007) |
| "This prospective, double-blind, randomized, placebo-controlled study was designed to determine the efficacy of dexmedetomidine compared with lidocaine in reducing the pain of propofol and rocuronium injection pain." | 9.12 | Does dexmedetomidine reduce the injection pain due to propofol and rocuronium? ( Altunkaya, H; Ayoğlu, H; Cukdar, G; Ozer, Y; Ozkoçak, I; Yapakçi, O, 2007) |
| "35 microg kg(-1) min(-1)) and a premixture of lidocaine with propofol (mixture of propofol 1% and lidocaine 1% in a 10:1 ratio) was compared with either treatment alone in the prevention of pain on propofol injection." | 9.12 | Reduction of pain on injection of propofol: combination of pretreatment of remifentanil and premixture of lidocaine with propofol. ( Baek, W; Jeon, Y; Kim, J; Kim, S; Kwak, K; Lim, D; Park, S, 2007) |
| "We conducted this randomized double-blind trial to determine the extent of further pain reduction by adding lidocaine to Lipuro propofol." | 9.12 | Lidocaine is more efficient than the choice of propofol formulations to reduce incidence of pain on induction. ( Elliot, SC; Krishnan, K; Mallick, A; Vucevic, M, 2007) |
| "Pain at the site of intravenous injection of propofol is a common clinical finding." | 9.12 | Sustained intravascular exposure to propofol does not prolong pain at the site of injection. ( Akeson, J; Karlsson, A; Lagerkranser, M; Liljeroth, E, 2007) |
| "Local pain on injection of propofol remains a considerable problem in clinical anaesthesiology." | 9.12 | Low-dose propofol reduces the incidence of moderate to severe local pain induced by the main dose. ( Akeson, J; Karlsson, A; Lagerkranser, M; Liljeroth, E, 2007) |
| "The combination of two different analgesic modalities, remifentanil and lidocaine completely abolishes moderate and severe pain associated with propofol injection, and significantly reduces the incidence of mild pain when compared with each drug used alone." | 9.12 | Multimodal analgesia to prevent propofol-induced pain: pretreatment with remifentanil and lidocaine versus remifentanil or lidocaine alone. ( Al-Alami, AA; Aouad, MT; Baraka, AS; Siddik-Sayyid, SM, 2007) |
| "7%) complained of pain in the lidocaine plus remifentanil group compared with 15 (35." | 9.12 | A combination of lidocaine (lignocaine) and remifentanil reduces pain during propofol injection. ( Choi, G; Chung, H; Han, C; Jeon, Y; Kim, S; Kwak, K; Lim, C; Lim, D, 2007) |
| "Injection pain was twice as common with ketamine-propofol admixture than with lidocaine-propofol admixture." | 9.12 | A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture. ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007) |
| "Flurbiprofen axetil emulsion (FA), a prodrug of nonsteroidal anti-inflammatory drugs (NSAIDs) that is widely used for perioperative pain relief in Japan, has been effective for reducing propofol injection pain, but the mechanism is unclear." | 9.12 | Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration. ( Kaminoh, Y; Tanimoto, M; Tashiro, C; Tatara, T; Tsujimoto, S; Ueki, R, 2007) |
| "Pain on injection is a recognized adverse event (AE) with propofol, an agent used to induce general anesthesia in surgical patients." | 9.12 | Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients. ( Fujii, Y; Nakayama, M, 2007) |
| "The incidence of pain on injection of propofol MCT/LCT was not different from that caused by propofol LCT with pretreatment of lidocaine and the intensity of pain on propofol MCT/LCT injection decreased significantly when using lidocaine pretreatment." | 9.12 | Pain on injection of propofol: propofol LCT vs propofol MCT/LCT with or without lidocaine pretreatment. ( Burimsittichai, R; Charuluxananan, S; Kumwilaisuk, K; Premsamran, P; Sathapanawath, N; Tingthanathikul, W, 2006) |
| "To determine whether a small dose of propofol before induction decreases pain with injection using two different formulas of propofol-10% long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) and LCT." | 9.12 | Evaluation of low-dose propofol preadministration to attenuate vascular pain during induction of anesthesia. ( Kodaka, M; Koyama, K; Maeyama, A; Miyao, H; Okuyama, S, 2007) |
| "Pain on injection of propofol is unpleasant." | 9.12 | Reduction of pain during induction with target-controlled propofol and remifentanil. ( Jung, CW; Lee, JR; Lee, YH, 2007) |
| "Propofol, a commonly used anesthetic, often causes pain on injection." | 9.12 | Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine. ( Boker, A; Ertok, E; Saadawy, I, 2007) |
| "Propofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) that have been reported to reduce injection pain." | 9.12 | A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection. ( Boonthom, N; Chalacheewa, T; Jommaroeng, P; Rungsithiwan, W; Sundarathiti, P, 2007) |
| "The authors used positron emission tomography to measure the effect of various concentrations of propofol on pain-evoked changes in regional cerebral blood flow." | 9.11 | Dose-dependent effects of propofol on the central processing of thermal pain. ( Backman, SB; Bushnell, MC; Fiset, P; Hofbauer, RK; Plourde, G, 2004) |
| "Pain on injection caused by Propofol-LCT with pre-treatment of lidocaine and Propofol-MCT/LCT alone is shown to be equivalent." | 9.11 | [Propofol-LCT versus propofol-MCT/LCT with or without lidocaine - a comparison on pain on injection]. ( Haaf-Von-Below, S; Kuhlen, R; Kunitz, O; Lösing, R; Rossaint, R; Schulz-Stübner, S, 2004) |
| "Intravenous magnesium and lidocaine pretreatment are equally effective in attenuating propofol-induced pain." | 9.11 | Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified. ( Agarwal, A; Dhiraj, S; Gupta, D; Pandey, CK; Pandey, R; Raza, M; Singh, PK; Singh, U, 2004) |
| "Propofol causes pain on IV injection in 28%-90% of patients." | 9.11 | Pretreatment with thiopental for prevention of pain associated with propofol injection. ( Agarwal, A; Ansari, MF; Dhiraj, S; Gupta, D; Pandey, R; Raza, M; Singh, PK; Singh, U, 2004) |
| "Propofol causes pain or discomfort on injection in 28%-90% of patients." | 9.11 | Pain during injection of propofol: the effect of prior administration of butorphanol. ( Agarwal, A; Dhiraaj, S; Gupta, D; Pandey, CK; Pandey, R; Raza, M; Singh, PK; Singh, U, 2004) |
| " In order to evaluate if light propofol anesthesia in the pediatric oncology ward (POW) could improve the management of procedure pain and anxiety, a questionnaire was developed." | 9.11 | Propofol or propofol--alfentanil anesthesia for painful procedures in the pediatric oncology ward. ( Bredlöv, B; Olsson, GL; Söderhäll, S; Von Heijne, M, 2004) |
| "Propofol is well known for its association with pain on injection." | 9.11 | Propofol-induced injection pain: comparison of a modified propofol emulsion to standard propofol with premixed lidocaine. ( Adam, S; Dirckx, M; Jonsson, D; Klein, J; Pelka, M; van Bommel, J, 2004) |
| "We investigated the early recovery characteristics and pain relief of adult patients during combined anesthesia with (epidural and general), either with propofol or sevoflurane for maintenance in major abdominal surgery." | 9.11 | Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief. ( Duru, S; Elar, Z; Hepağuşlar, H; Ozkardeşler, S; Ozzeybek, D; Taşdöğen, A, 2004) |
| "5 mg, 5 mg, 10 mg) for reducing pain on injection of propofol in 100 patients scheduled for elective surgery." | 9.11 | Effect of metoclopramide on pain on injection of propofol. ( Fujii, Y; Uemura, A, 2004) |
| "Propofol causes pain on intravenous injection in 28 to 90% of patients." | 9.11 | Pain during injection of propofol: the effect of prior administration of ephedrine. ( Agarwal, A; Dhiraaj, S; Gupta, D; Ranjan, R; Raza, M; Singh, PK; Singh, U; Singhal, V, 2004) |
| "A common drawback of propofol is pain on injection and lidocaine is commonly mixed with propofol to reduce its incidence and severity." | 9.11 | Comparison of Propofol-Lipuro with propofol mixed with lidocaine 10 mg on propofol injection pain. ( Abdul-Latif, MS; Kam, E; McCluskey, A, 2004) |
| "The incidence of pain on injection of propofol has been reported to be 70%." | 9.11 | Pain on injection: a double-blind comparison of propofol with lidocaine pretreatment versus propofol formulated with long- and medium-chain triglycerides. ( Kern, C; Landau, R; Schaub, E, 2004) |
| "To compare the efficacy of alfentanil, remifentanil, and saline in minimizing the propofol injection pain." | 9.11 | The effects of alfentanil or remifentanil pretreatment on propofol injection pain. ( Balkan, BK; Ellidokuz, H; Gökel, E; Günerli, A; Iyilikci, L, 2004) |
| "In a randomized, double-blind, controlled trial, 120 ASA 1 or 2 patients were allocated to receive diclofenac or normal saline as pretreatment to assess their effect on incidence and severity of pain during propofol injection." | 9.11 | Effect of diclofenac pretreatment on pain during propofol injection. ( Agarwal, D; Mohta, M; Sandhu, K; Sethi, AK, 2004) |
| "We studied the effect of propofol, a widely used sedative-hypnotic drug, on pain perception." | 9.11 | The effect of propofol on thermal pain perception. ( Frölich, MA; Heft, MW; Price, DD; Robinson, ME; Shuster, JJ; Theriaque, DW, 2005) |
| "A randomized double-blind study compared two methods of preventing the pain from injection of propofol, lignocaine pre-treatment followed by propofol and lignocaine added to propofol." | 9.11 | Preventing pain on injection of propofol: a comparison between lignocaine pre-treatment and lignocaine added to propofol. ( Lee, P; Russell, WJ, 2004) |
| "In the burns group, significantly greater BIS values relating to increasing propofol TCI were noted at deeper anesthesia when compared with controls; at > or =3." | 9.11 | The relationship between bispectral index and targeted propofol concentration is biphasic in patients with major burns. ( Han, KW; Han, TH; Kil, HY; Kim, KM; Kwak, IS; Lee, JH, 2005) |
| "Local pain at the site of intravenous (iv) injection of propofol remains a considerable problem in clinical anaesthesiology, and particularly so in infants." | 9.11 | Less local pain on intravenous infusion of a new propofol emulsion. ( Akeson, J; Liljeroth, E, 2005) |
| " We studied its efficacy in decreasing the pain associated with IV administration of propofol and compared it with mixing lidocaine with propofol." | 9.11 | Bacteriostatic saline containing benzyl alcohol decreases the pain associated with the injection of propofol. ( Minogue, SC; Sun, DA, 2005) |
| "This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol." | 9.11 | Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005) |
| "25 patients (83%) complained of pain in the placebo group, compared with 12 (40%) in the lidocaine group (P < 0." | 9.11 | A lidocaine/metoclopramide combination decreases pain on injection of propofol. ( Fujii, Y; Nakayama, M, 2005) |
| " lidocaine and nitrous oxide (N2O) in oxygen (O2) inhalation pre-treatment was compared with either treatment alone in the prevention of pain on propofol injection." | 9.11 | A combination of lidocaine and nitrous oxide in oxygen is more effective in preventing pain on propofol injection than either treatment alone. ( Elsaigh, I; Galvin, E; Harmon, D; Leonard, I; Niazi, A; Wahid, Z, 2005) |
| "A new MCT-LCT propofol formulation as a plain solution was associated with a higher incidence of injection pain than LCT propofol with added lidocaine when used for induction of anaesthesia in children." | 9.11 | Propofol injection pain in children: a prospective randomized double-blind trial of a new propofol formulation versus propofol with added lidocaine. ( Eksborg, S; Georgiadi, A; Lönnqvist, PA; Nyman, Y; von Hofsten, K, 2005) |
| "Propofol formulated in medium- and long-chain triglycerides (MCT/LCT) is thought to cause less pain on injection." | 9.11 | The effects of intravenous lidocaine on pain during injection of medium- and long-chain triglyceride propofol emulsions. ( Chong, SY; Goh, MH; Tan, KH; Yew, WS, 2005) |
| "In a randomized, double-blind, prospective trial we compared the efficacy of pre-treatment with nitrous oxide (with or without premixed lignocaine in propofol) for the prevention of propofol-induced pain." | 9.11 | Effect of nitrous oxide in reducing pain of propofol injection in adult patients. ( Neema, PK; Rathod, RC; Sinha, PK, 2005) |
| "The present study was undertaken to examine the efficacy of flurbiprofen axetil for reducing pain on propofol injection in Japanese adult surgical patients." | 9.11 | Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients. ( Fujii, Y; Shiga, Y, 2005) |
| "Pain on injection of propofol continues to be a problem for anesthesiologists." | 9.11 | Pain on injection of lipid-free propofol and propofol emulsion containing medium-chain triglyceride: a comparative study. ( Dubey, PK; Kumar, A, 2005) |
| "The numbers of patients with severe and mild pain were larger in the order: LCT group (10 and 31 patients, respectively) > flurbiprofen 1 group (3 and 19) > or = MCT/LCT group (1 and 14) > or = lidocaine group (2 and 11) > flurbiprofen group (0 and 0)." | 9.11 | How to decrease pain at rapid injection of propofol: effectiveness of flurbiprofen. ( Nishiyama, T, 2005) |
| "Pain on injection, reported in 28-90% of patients, is one of the most described side effects of the intravenous application of propofol." | 9.11 | Comparison on pain on injection of a small particle size-lipid emulsion of propofol and standard propofol with or without lidocaine. ( Diregpoke, S; Krobbuaban, B; Kumkeaw, S; Tanomsat, M, 2005) |
| " 15 and 30 mg ketorolac reduces pain following propofol injection." | 9.10 | Effect of pretreatment with ketorolac on propofol injection pain. ( Buerkle, H; Chou, AK; Huang, YW; Lee, TH; Lin, CR; Lin, SH; Lu, CY; Muhammad, R; Yang, LC, 2002) |
| "5 mg neostigmine (Group N, n = 35), 1 ml 2% lidocaine (Group L, n = 35), or 1 ml normal saline (Group C, n = 35) as pretreatment to reduce pain on propofol injection." | 9.10 | Can neostigmine reduce propofol injection pain? ( Chang, DP; Mok, MS; Pang, WW; Wang, CS; Yeh, M, 2002) |
| "48 mmol, injected 20 s before the administration of propofol significantly reduced the incidence of pain caused by a propofol injection and may be useful in minimizing this common side effect." | 9.10 | The use of magnesium sulfate to prevent pain on injection of propofol. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Süt, N; Turan, A, 2002) |
| "Although it is well-known that 2% lidocaine has an effective action for preventing propofol-induced pain, it has been unclear whether or not lidocaine of the concentration below 2% has the effective action similar to 2% lidocaine." | 9.10 | [Effects of concentration and dosage of lidocaine on preventing the pain on injection of propofol]. ( Adachi, H; Harada, T; Hirosawa, J; Inagaki, Y; Ishibe, Y; Otsuki, A; Tsubokura, H, 2002) |
| "One hundred seventy-six patients (ASA physical status I or II) presenting for elective surgery were randomly allocated into six study groups to compare the incidence of propofol-induced pain after pretreatment with different doses of ephedrine as compared with lidocaine." | 9.10 | Ephedrine reduces the pain from propofol injection. ( Cheong, MA; Choi, WJ; Kim, KS, 2002) |
| "To investigate if 50% nitrous oxide reduces the pain during injection of propofol mixed with lidocaine in children." | 9.10 | In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine. ( Beh, T; Kim, J; Splinter, W, 2002) |
| " Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14-52%, P = 0." | 9.10 | Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. ( Harmon, D; Lowe, D; Rozario, C, 2003) |
| "25 microg x kg(-1) x min(-1) with 40 mg lidocaine and placebo in the prevention of injection pain due to intravenous propofol administration (1." | 9.10 | Prevention of propofol-induced injection pain by remifentanil: a placebo-controlled comparison with lidocaine. ( Boldt, J; Maleck, WH; Piper, SN; Roehm, KD, 2003) |
| "The purpose of this prospective study was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy." | 9.10 | Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia. ( Kararmaz, A; Kaya, S; Ozyilmaz, MA; Turhanoglu, S, 2003) |
| "Pain is often experienced when propofol is injected, and intravenous lidocaine is often effective in preventing such pain." | 9.10 | Pain on injection of propofol: comparison of metoprolol with lidocaine. ( Aşik, I; Gülay, I; Tulunay, M; Yörükoğlu, D, 2003) |
| "We assessed the effectiveness of a 5-microm filter in reducing propofol-induced pain and determined whether any reduction is due to removal of contaminants or an alteration in flow characteristics." | 9.10 | A 5-microm filter does not reduce propofol-induced pain. ( Barry, J; Brimacombe, J; Hellier, C; Newell, S, 2003) |
| "Topical anesthesia using 60% lidocaine tape reduces the incidence of propofol injection pain." | 9.10 | The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol. ( Currer, BA; McCluskey, A; Sayeed, I, 2003) |
| "In patients having short painful surgery, less propofol does not give faster recovery as long as the same anaesthetic level (as indicated by BIS and clinical signs) is maintained by more remifentanil." | 9.10 | Early recovery after remifentanil-pronounced compared with propofol-pronounced total intravenous anaesthesia for short painful procedures. ( Detsch, O; Hackner, C; Jelen-Esselborn, S; Kochs, E; Schneider, G, 2003) |
| "To assess incidence and intensity of pain on intravenous injection of propofol (CAS 2078-548) in an emulsion of medium-chain/long-chain triglycerides (MCT/LCT, 50:50) in patients undergoing different elective surgical interventions." | 9.10 | Incidence of pain after intravenous injection of a medium-/long-chain triglyceride emulsion of propofol. An observational study in 1375 patients. ( Bachmann-Mennenga, B; Heesen, M; Ohlmer, A, 2003) |
| "The incidence of pain of the infusion was significantly lower in patients pretreated with ketamine (8% vs 37%, P = 0." | 9.10 | Pretreatment with intravenous ketamine reduces propofol injection pain. ( Barbi, E; Gagliardo, A; Gerarduzzi, T; Marchetti, F; Neri, E; Sarti, A; Ventura, A, 2003) |
| "Propofol is commonly used for induction and maintenance of anesthesia, but the pain during injection of propofol remains a clinical problem." | 9.10 | [Nicorandil reduces incidence and severity of pain on propofol injection]. ( Iwasaki, T; Shimizu, Y; Takasaki, M; Yoshimura, Y, 2003) |
| "The purpose of this study was to evaluate the effect of pre-treatment with ketamine on the reduction of pain during injection of propofol in adult patients." | 9.10 | [Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection]. ( Kumazawa, T; Masamune, T; Nonaka, A; Suzuki, S, 2002) |
| "To compare the efficacy of tramadol and ondansetron in minimizing the pain due to injection of propofol in 100 patients." | 9.10 | The prevention of propofol injection pain by tramadol or ondansetron. ( Karamanlioglu, B; Kaya, G; Memiş, D; Pamukçu, Z; Turan, A, 2002) |
| " bolus infusion rate of propofol does not influence drug-induced local pain on injection, at least not within the infusion rate interval studied." | 9.10 | Propofol infusion rate does not affect local pain on injection. ( Akeson, J; Grauers, A; Liljeroth, E, 2002) |
| "In a randomised, double-blinded, two-centre trial we evaluated the effect of a microbiological filter (Supor, Pall Life Sciences) on propofol injection pain." | 9.10 | Efficacy of microfiltration in decreasing propofol-induced pain. ( Conn, D; Davies, AF; Dexter, T; Hopwood, B; Vadodaria, B, 2002) |
| "To compare the effects of nitrous oxide with lidocaine on pain on injection caused by propofol in children." | 9.10 | [Prevention of pain on injection with propofol in children: comparison of nitrous oxide with lidocaine]. ( Ecoffey, C; Geslot, D; Lembert, N; Wodey, E, 2002) |
| "The iontophoretic application of lidocaine was compared with intravenous lidocaine to assess the relative efficacy of reducing pain during propofol administration." | 9.10 | Iontophoretically applied lidocaine and the prevention of pain associated with the injection of intravenous propofol: a comparison with intravenous lidocaine. ( Asif, M; Rowbotham, DJ; Sharpe, P; Victoria, A, 2002) |
| " retention of metoclopramide with tourniquet is as good as lidocaine and may be a useful alternative for reducing pain on propofol injection." | 9.09 | Pain on injection of propofol: the mitigating influence of metoclopramide using different techniques. ( Chang, DP; Hwang, MH; Liaw, WJ; Pang, WW, 1999) |
| "We used a randomized, controlled, double-blinded design to study the effect of ondansetron (OND) pretreatment on the pain produced by the IV injection of propofol." | 9.09 | Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study. ( Ambesh, SP; Dubey, PK; Sinha, PK, 1999) |
| "We have compared iontophoretically and locally applied lidocaine for relief of pain on propofol injection." | 9.09 | Iontophoretically applied lidocaine reduces pain on propofol injection. ( Liddle, A; Maslowski, P; Rowbotham, DJ; Sadler, PJ; Thompson, HM, 1999) |
| "To determine the optimal concentration of lidocaine that reduces pain on injection of a propofol-lidocaine mixture." | 9.09 | The optimal effective concentration of lidocaine to reduce pain on injection of propofol. ( Chu, CC; Ho, CM; Lee, TY; Sun, MS; Tsou, MY, 1999) |
| "The purpose of this study was to compare the effect of premixed 5% dextrose in Ringer's acetate solution and premixed lidocaine with propofpl on the reduction of pain during injection of propofol in adult patients." | 9.09 | [Premixing of 5% dextrose in Ringer's acetate solution with propofol reduces incidence and severity of pain on propofol injection]. ( Kashimoto, S; Kumazawa, T; Nonaka, A; Oguchi, T; Sugawara, T; Tamaki, F, 1999) |
| " The pain which occurs as a response to an intravenous injection of Propofol is one of the main obstacles to its use as an anesthetic." | 9.09 | [Administration of propofol. Addition of lidocaine eases the pain]. ( Fernández, V; Hernández, S; López, S; Santamaría, R, 1999) |
| "To elucidate the mechanism of propofol-induced pain on injection, we performed several studies using nafamostat mesilate, a kallikrein inhibitor, or lidocaine." | 9.09 | A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate. ( Iwama, H; Nakane, M, 1999) |
| "We performed a randomised, double-blind, prospective trial to discover whether intravenous ketorolac 10 mg made up to 2 ml with saline, with or without venous occlusion for 2 min, reduces the pain on injection of propofol." | 9.09 | Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol. ( Barkshire, KF; Dexter, T; Yull, DN, 2000) |
| "A prospective, randomized, double-blind study was conducted to determine whether cooled intravenous propofol reduces the incidence of pain on induction of anaesthesia in children." | 9.09 | Propofol and pain on induction: the effect of injectate temperature in children. ( Burden, J; Lewis, I; Pickford, A, 2000) |
| "Propofol injection associated with a high incidence of pain is well known." | 9.09 | Propofol-sodium thiopental admixture reduces pain on injection. ( Cheng, KS; Kau, YC; Wu, RS, 2000) |
| "The purpose of this study was to compare the younger and older patients in the incidence and the severity of the pain during injection of propofol." | 9.09 | [Effect of pre-mixed lidocaine with propofol on propofol injection pain in elderly patients]. ( Kumazawa, T; Nonaka, A; Suzuki, M; Suzuki, S; Tamaki, F, 2000) |
| "To determine whether epidural lidocaine reduces the severity of propofol injection pain compared with iv lidocaine." | 9.09 | Epidural anesthesia with lidocaine reduces propofol injection pain. ( Inoue, T; Ogawa, R; Ogura, A; Wajima, Z; Yoshikawa, T, 2001) |
| "Pain intensity at the site of propofol injection was found not to be influenced by simultaneous iv infusion of carrier fluid." | 9.09 | Pain on injection of propofol with or without infusion of carrier fluid. ( Akeson, J; Grauers, A; Liljeroth, E, 2001) |
| "In a test of two formulations of propofol for induction, patients experienced less pain with the formulation in Intralipid (Propofol-Lipuro 1%) than with Diprivan 1%." | 9.09 | Propofol in an emulsion of long- and medium-chain triglycerides: the effect on pain. ( Doenicke, AW; O'Connor, MF; Rau, J; Roizen, MF; Strohschneider, U, 2001) |
| "Propofol is frequently associated with pain on injection." | 9.09 | Role of tramadol in reducing pain on propofol injection. ( Cheong, KF; Wong, WH, 2001) |
| "In a randomised, controlled, double-blinded trial to study the effect of ondansetron pretreatment on the pain produced after intravenous injection of rocuronium and propofol in comparison with lidocaine, 60 patients were randomly assigned to one of three groups." | 9.09 | Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. ( Chen, FG; Ng, HP; Reddy, MS, 2001) |
| "We examined the analgesic effects of orally administered clonidine on pain induced by injection of propofol (Diprivan; 2,6-diisopropyl phenol)." | 9.09 | Orally administered clonidine significantly reduces pain during injection of propofol. ( Inoue, T; Ogawa, R; Ogura, A; Wajima, Z; Yoshikawa, T, 2001) |
| "This prospective, randomised, double-blind study was designed to compare the incidence and intensity of pain on injection of propofol formulated in a mixture of medium- and long-chain triglycerides, Propofol-MCT/LCT 1% (Propofol-Lipuro, B." | 9.09 | [Injection pain from propofol-MCT-LCT in children. A comparison with propofol-LCT]. ( Beerhalter, U; Erdkönig, R; Larsen, B; Larsen, R, 2001) |
| "To investigate the effect of simultaneous bolus injection of 2% lidocaine 2 ml on preventing the pain on propofol injection, 80 patients were randomly assigned to one of four study groups; Group I received simultaneous bolus injection of 2% lidocaine 2 ml with infusion of propofol; Group II received bolus injection of saline 2 ml, 10 s before the start of infusion of propofol-lidocaine mixture; Groups III and IV received bolus injections of lidocaine and saline, separately 10 s before starting propofol infusion." | 9.09 | [Efficacy of simultaneous bolus injection of lidocaine with propofol on pain caused by propofol injection]. ( Adachi, H; Harada, T; Hirosawa, J; Inagaki, Y; Ishibe, Y; Otsuki, A; Tsubokura, H, 2001) |
| "Pain on injection is a major disadvantage of propofol, experienced by the vast majority of patients." | 9.09 | [Less pain on injection by a new formulation of propofol? A comparison with propofol LCT]. ( Beerhalter, U; Biedler, A; Brandt, A; Brün, K; Doege, F; Erdkönig, R; Larsen, B; Larsen, R, 2001) |
| "The aim of this study was to investigate pain perception during thiopentone or propofol infusions for sedation." | 9.08 | Sedation with intravenous infusions of propofol or thiopentone. Effects on pain perception. ( Kolletzki, M; Wilder-Smith, CH; Wilder-Smith, OH, 1995) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 9.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| "This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia." | 9.08 | Thiopentone pretreatment for propofol injection pain in ambulatory patients. ( Haugen, RD; Merrick, PM; Vaghadia, H; Waters, T, 1995) |
| "We undertook a randomized, placebo-controlled, double-blind study to compare the use of alfentanil 1 mg and lidocaine 40 mg for the reduction of pain during injection of propofol." | 9.08 | Prevention of pain on injection of propofol: a comparison of lidocaine with alfentanil. ( Gajraj, NM; Nathanson, MH; Russell, JA, 1996) |
| "We hypothesized that the concentration of propofol in the aqueous phase may be the most important variable responsible for the pain experienced during injection of the drug." | 9.08 | Reducing pain during propofol injection: the role of the solvent. ( Babl, J; Doenicke, AW; Kellermann, W; Rau, J; Roizen, MF, 1996) |
| "9% saline (1 ml) on a double-blind basis, as pretreatment to reduce pain on injection of propofol." | 9.08 | Modification of pain on injection of propofol. A comparison of pethidine and lignocaine. ( Flynn, C; Lohan, D; Lyons, B; McCarroll, M, 1996) |
| "Propofol has been shown to cause pain on injection." | 9.08 | The effect of temperature upon pain during injection of propofol. ( Davidson, JA; Fletcher, GC; Gillespie, JA, 1996) |
| "A randomised, controlled, single-blind study was performed on 100 patients to investigate a new method of reducing pain on propofol injection." | 9.08 | Injection pain with propofol. Reduction with aspiration of blood. ( Jameson, P; McDonald, DS, 1996) |
| "A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol." | 9.08 | The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996) |
| "To define the optimal dose of lidocaine to be added to propofol to reduce the incidence of pain during its injection." | 9.08 | Preventing pain during injection of propofol: the optimal dose of lidocaine. ( Gajraj, NM; Nathanson, MH, 1996) |
| "To compare the local efficacy of lidocaine and fentanyl in reducing propofol injection pain (PIP), we conducted a prospective randomized double-blind study in 75 ASA I and II adult patients." | 9.08 | Reduction of propofol pain--fentanyl vs lidocaine. ( Alyafi, WA; Rangasami, J, 1996) |
| ") lidocaine and topical nitroglycerin ointment in preventing pain during propofol injection." | 9.08 | Effects of topical nitroglycerin and intravenous lidocaine on propofol-induced pain on injection. ( Beven, M; Carpenter, T; Laseter, JT; Mascha, E; Maurer, WG; O'Hara, JR; Sprung, J, 1997) |
| "kg-1 propofolis not effective in the treatment of postoperative vomiting in children after adenotonsillectomy when a standardized anaesthetic with thiopentone, halothane, nitrous oxide, and 1." | 9.08 | Subhypnotic propofol does not treat postoperative vomiting in children after adenotonsillectomy. ( Carr, AS; Lerman, J; McAuliffe, G; Sikich, N; Smith, HS; Zestos, MM, 1997) |
| "The purpose of this study was to confirm the effect of premixed lidocaine for the reduction of pain during injection of propofol in adult patients." | 9.08 | [Premixing lidocaine reduces the incidence and severity of pain on injection of propofol]. ( Akazawa, S; Fukuda, H; Inoue, S; Kasuda, H; Kawakami, T; Konishi, R; Mitsuhata, H; Saitoh, J; Saitoh, K; Shimizu, R; Suzuki, H, 1997) |
| "Pain is a well known complication of propofol injection." | 9.08 | [Effect of lidocaine administration mode on decreasing injection pain caused by propofol]. ( Bornscheuer, A; Goldmann, R; Kirchner, E, 1997) |
| "Propofol has the disadvantage of pain on injection." | 9.08 | Effect of lignocaine and pH on propofol-induced pain. ( Englesson, S; Eriksson, M; Hartvig, P; Niklasson, F, 1997) |
| " set (DLIS) decreases the incidence of propofol injection pain compared with single lumen i." | 9.08 | Reduction of propofol injection pain with a double lumen i.v. set. ( Angst, MS; Brock-Utne, JG; Mackey, SC; Tataru, CD; Zupfer, GH, 1997) |
| "We determined whether pretreatment with topical 60% lidocaine tape reduced the incidence of pain on injection of propofol compared with mixing intravenous lidocaine with propofol." | 9.08 | Pretreatment with topical 60% lidocaine tape reduces pain on injection of propofol. ( Hosoda, R; Kimura, T; Komatsu, T; Komura, Y; Nishiwaki, K; Shimada, Y; Yokota, S, 1997) |
| "Propofol is frequently associated with pain on injection." | 9.08 | Pain on injection of propofol. A comparison of cold propofol with propofol premixed with lignocaine. ( Koay, CK; Parmar, AK, 1998) |
| "Intra- and postoperative wake-up tests were performed together with somatosensory cortical evoked potentials (SCEPs) monitoring in 40 patients randomized to either midazolam (M) or propofol (P) infusions for scoliosis surgery." | 9.08 | Midazolam-flumazenil versus propofol anaesthesia for scoliosis surgery with wake-up tests. ( Hesselbjerg, L; Koscielniak-Nielsen, ZJ; Stens-Pedersen, HL, 1998) |
| ") retention of fentanyl and lidocaine in reducing the pain on i." | 9.08 | Comparison of intravenous retention of fentanyl and lidocaine on local analgesia in propofol injection pain. ( Chang, DP; Chung, YT; Hong, MH; Huang, S; Lin, SS; Pang, WW, 1997) |
| "9% saline (1 ml) on propofol injection pain." | 9.08 | The effect of ketamine pretreatment on propofol injection pain in 100 women. ( Kua, SW; Onsiong, MK; Tan, CH, 1998) |
| "Pain on injection is one of the well-known side effects of propofol." | 9.08 | [Pain-free injection of propofol]. ( Ichimiya, T; Kamada, Y; Kobayashi, Y; Kumagai, A; Namiki, A; Seki, S; Tsuchida, H, 1998) |
| "We evaluated the efficacy of the 60% lidocaine tape in alleviating pain associated with intravenous propofol administration in 71 gynecological patients." | 9.08 | [Sixty percent lidocaine tape alleviates pain on injection of propofol after diminishing venipuncture pain]. ( Akatsuka, M; Doi, Y; Inamori, K; Kunimasa, K; Minami, T; Mori, H; Ohnaka, M; Ohtsuka, M; Uda, R, 1998) |
| "We compared the effect of fentanyl and lidocaine on pain during injection of propofol." | 9.08 | [Reduction of pain on injection of propofol: a comparison of fentanyl with lidocaine]. ( Aketa, K; Ichimiya, T; Kobayashi, Y; Naganuma, R; Namiki, A; Seki, S, 1998) |
| "The purpose of the present study is to compare the injection pain of propofol with that of benzodiazepines when used for intravenous sedation." | 9.08 | Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. ( Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T, 1998) |
| "We have examined the preventative effect of nafamostat mesilate, a kallikrein inhibitor, on pain on injection with propofol in a randomized, double-blind study." | 9.08 | Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol. ( Iwama, H; Kaneko, T; Kato, M; Nakane, M; Ohmori, S; Okuaki, A; Watanabe, K, 1998) |
| "Lignocaine has been shown to reduce the incidence of pain on injection of propofol." | 9.07 | Propofol injection pain: comparing the addition of lignocaine or metoclopramide. ( Mecklem, DW, 1994) |
| "A controlled, double-blind study was performed to compare the prior administration of intravenous saline 4 ml (n = 36), lignocaine 20 mg (n = 36) or thiopentone 100 mg (n = 43) on the pain produced by intravenous injection of propofol." | 9.07 | Pain during injection of propofol. The effect of prior administration of thiopentone. ( Lee, TW; Loewenthal, AE; Strachan, JA; Todd, BD, 1994) |
| "A controlled randomized double-blinded clinical study was undertaken to evaluate and compare the efficacy of three methods of preventing pain during injection of propofol on induction of anesthesia." | 9.07 | Pain on injection of propofol. ( Chen, GT; Chen, TY; Hwang, MH; Lin, JC; Lin, SS, 1994) |
| "We have compared two groups (n = 22) of unpremedicated patients to determine if the pain caused by injection of propofol could be modified by alfentanil." | 9.07 | Pretreatment with alfentanil reduces pain caused by propofol. ( Bowen, DJ; Fletcher, JE; Seavell, CR, 1994) |
| "The effect of fentanyl, administered immediately before propofol, when pain is experienced at the site of propofol injection was studied in 28 children undergoing elective surgery." | 9.07 | [Fentanyl prevents the pain at the site of propofol injection]. ( Chessa, D; Cossu, F; Serra, G, 1992) |
| "We have conducted a randomized, double-blind study in 255 ASA I and II patients to compare the efficacy of lignocaine and metoclopramide in minimizing the pain of injection of i." | 9.07 | Pain on injection of propofol: comparison of lignocaine with metoclopramide. ( Fee, JP; Ganta, R, 1992) |
| "kg-1 on reducing injection pain caused by propofol was compared with lignocaine 10 mg mixed with propofol (Lign)." | 9.07 | Injection pain, cardiovascular changes and recovery following induction of anaesthesia with propofol in combination with alfentanil or lignocaine in children. ( Hiller, A; Saarnivaara, L, 1992) |
| "In a single-blind study of 100 children aged 1 to 10 years, the minimum effective dose of lignocaine required to prevent injection pain due to propofol was 0." | 9.07 | The minimum effective dose of lignocaine to prevent injection pain due to propofol in children. ( Cameron, E; Crofts, S; Johnston, G; Morton, NS, 1992) |
| "Propofol has a high incidence of pain with injection, particularly into small veins." | 9.07 | Lidocaine for the prevention of pain due to injection of propofol. ( Davis, FM; King, SY; Murchison, DJ; Pryor, PJ; Wells, JE, 1992) |
| "We evaluated the efficacy of intravenous lidocaine, with and without a tourniquet, to decrease the intensity of pain during intravenous propofol injection in 82 patients undergoing general anesthesia." | 9.07 | Tourniquet at 50 mm Hg followed by intravenous lidocaine diminishes hand pain associated with propofol injection. ( Holak, EJ; Mangar, D, 1992) |
| "Three modes of administration of alfentanil were assessed in order to reduce pain on injection with propofol." | 9.07 | [The effect of alfentanil on pain caused by the injection of propofol during anesthesia induction in children]. ( Dru, M; Journois, D; Lory, C; Playe, E, 1991) |
| "A single-blind, randomised, controlled study was undertaken to compare the efficacy of three methods of preventing pain during injection of propofol on induction of anaesthesia." | 9.07 | Effect of prior administration of cold saline on pain during propofol injection. A comparison with cold propofol and propofol with lignocaine. ( Barker, P; Langton, JA; Murphy, P; Rowbotham, DJ, 1991) |
| "The emulsion formulation of propofol (Diprivan) evokes pain on i." | 9.07 | Pain on injection of propofol: effects of concentration and diluent. ( Arndt, JO; Klement, W, 1991) |
| "Pain on injection of propofol was assessed in a controlled, randomised study of 273 patients." | 9.07 | Modification of pain on injection of propofol--a comparison between lignocaine and procaine. ( A'Hern, RP; Edwards, J; Moriarty, J; Nicol, ME; Robbie, DS, 1991) |
| "The purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol." | 9.07 | Optimal dose of lignocaine for preventing pain on injection of propofol. ( Gehan, G; Karoubi, P; Leroy, A; Pourriat, JL; Quinet, F; Rathat, C, 1991) |
| "A controlled randomised double-blind design was used to study the effect of lignocaine on the pain produced by intravenous injection of propofol." | 9.06 | Pain on injection of propofol. Methods of alleviation. ( Chadwick, S; Harper, NJ; Johnson, RA; Vohra, A, 1990) |
| "A double-blind, randomised clinical study was undertaken to compare the effect of temperature on the incidence and severity of the pain experienced on injection of propofol." | 9.06 | Pain on injection of propofol: the effect of injectate temperature. ( Hunter, S; McCrirrick, A, 1990) |
| "The efficacy of lignocaine (1%) mixed with propofol in reducing pain on injection with propofol was studied in 40 children undergoing elective surgery in a double-blind, randomized comparison with glucose (5%)." | 9.06 | Propofol as an induction agent in children: pain on injection and pharmacokinetics. ( Iisalo, E; Kanto, J; Rosenberg, P; Valtonen, M, 1989) |
| "Eight modes of administration of propofol were assessed in order to minimise the pain of injection." | 9.06 | Propofol: clinical strategies for preventing the pain of injection. ( Norman, J; Saunders, DA; Scott, RP, 1988) |
| "Propofol injection pain is a very common problem during the induction of general anesthesia." | 9.05 | Dexmedetomidine for prevention of propofol injection pain upon induction of anesthesia: a meta-analysis. ( Ji, L; Lan, Y; Sun, W; Wu, Q; Xia, C; Xu, X; Yang, S; Yu, G, 2020) |
| " All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled." | 8.95 | Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials. ( Fu, YZ; Lang, BC; Yang, CS; Zhang, LL; Zhang, WS, 2017) |
| "5-hydroxytryptamine3 (5-HT3) receptor antagonists have been commonly used to reduce propofol injection pain." | 8.93 | 5-HT3 Receptor Antagonists for Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials. ( Sun, L; Wang, T; Wang, W; Wu, LX; Zhang, CB; Zhou, L, 2016) |
| "The objective of this review was to determine the efficacy and adverse effects of lidocaine in preventing high-intensity pain on propofol injection." | 8.93 | Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults. ( Dej-Arkom, S; Euasobhon, P; Lumbiganon, P; Muangman, S; Pattanittum, P; Siriussawakul, A; Sriraj, W, 2016) |
| "To evaluate the anesthesia effect of etomidate and propofol on painless abortion surgery." | 8.93 | [Meta analysis for the anesthesia effect and adverse reactions of etomidate and propofol on the painless abortion surgery]. ( Li, W; Long, L; Wang, L; Xu, R, 2016) |
| "We conducted a comprehensive meta-analysis of studies to appraise the efficacy and safety of flurbiprofen axetil for controlling pain induced by propofol injection." | 8.90 | Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis. ( Bao, H; Luo, Z; Shi, H; Wang, H; Xu, L; Yu, Y; Zhang, L; Zhang, X; Zhang, Y; Zhao, Y; Zhu, J, 2014) |
| "To examine whether, according to the conclusions of a 2000 systematic review with meta-analysis on interventions to prevent pain from propofol injection that provided a research agenda to guide further research on the topic, subsequently published trials were more often optimally blinded, reported on children, and used the most efficacious intervention as comparator; and to check whether the number of new trials published each year had decreased and whether the designs of trials that cited the review differed from those that did not." | 8.90 | Ability of a meta-analysis to prevent redundant research: systematic review of studies on pain from propofol injection. ( Elia, N; Habre, C; Pöpping, DM; Tramèr, MR, 2014) |
| "To systematically determine the most efficacious approach for preventing pain on injection of propofol." | 8.87 | Prevention of pain on injection of propofol: systematic review and meta-analysis. ( Apfel, CC; George, E; Hornuss, C; Jalota, L; Kalira, V; Pace, NL; Radke, O; Shi, YY, 2011) |
| "Pain on injection of propofol is a common problem, the cause of which remains unknown." | 8.80 | Pain on injection of propofol. ( Onsiong, MK; Tan, CH, 1998) |
| "The best intervention to prevent pain on injection with propofol is unknown." | 8.80 | Prevention of pain on injection with propofol: a quantitative systematic review. ( Picard, P; Tramèr, MR, 2000) |
| "To discover the effect of propofol intravenous anesthesia along with press-needle therapy on analgesic effect during painless abortion." | 8.12 | Effect of Propofol Intravenous Anesthesia Combined with Press-Needle Therapy on Analgesic Effect during Painless Abortion. ( Chen, C; Fan, B; He, X; Liu, J; Wang, H; Wu, S; Zhu, X, 2022) |
| "In patients pretreated with lidocaine, no pain 56 (87." | 8.02 | Lidocaine for Reduction of Pain Induced by Propofol in a Tertiary Care Hospital: A Descriptive Cross-sectional Study. ( Bahadur Chand, M; Ghimire, B, 2021) |
| "BACKGROUND This study aimed to investigate the molecular mechanisms associated with the effects of propofol in a rat model of pain due to inflammation following subcutaneous injection with complete Freund's adjuvant (CFA)." | 7.91 | The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund's Adjuvant. ( Liu, H; Tan, S; Wang, Y; Zhu, S, 2019) |
| "To investigate the efficacy of lornoxicam in the prevention of the pain associated with propofol injection." | 7.85 | Lornoxicam use to reduce the pain associated with propofol injection. ( Aksoy, Y; Başak, N; Kaydu, A; Şahin, ÖF, 2017) |
| "A short review was carried out to see if mixing lidocaine with propofol is a safe and effective method in reducing the commonly reported pain at the injection site." | 7.85 | BET 1: Lidocaine with propofol to reduce pain on injection. ( Baombe, JP; Howard, L, 2017) |
| "The main objective was to verify whether propofol could allow us to administer care without causing major pain to patients with refractory pain at the end of life." | 7.85 | Sedation by Propofol for Painful Care Procedures at the End of Life: A Pilot Study. PROPOPAL 1. ( Castelli-Prieto, M; Ciais, JF; Jestin, C; Tremellat, F, 2017) |
| " Incisional pain was ranked as most undesirable, followed (in order) by vomiting, gagging on the tracheal tube, nausea, sore throat, propofol injection pain, shivering, intravenous puncture pain, and anxiety." | 7.85 | Is propofol injection pain really important to patients? ( Sun, L; Wang, W; Wu, L; Zhang, C, 2017) |
| "Propofol, a commonly used intravenous anesthetic agent, is known to at times cause pain sensation upon injection in humans." | 7.81 | Propofol-induced pain sensation involves multiple mechanisms in sensory neurons. ( Kashio, M; Nishimoto, R; Tominaga, M, 2015) |
| "Patients with higher anxiety scores (state and trait) required greater amounts of propofol to reach light (BIS=85) and moderate (BIS=75) levels of sedation, but only trait anxiety was significantly associated with propofol requirements in reaching a deep level of sedation (BIS=65)." | 7.78 | Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia. ( Chung, WY; Hong, JY; Kil, HK; Kim, GH; Kim, WO; Seo, H, 2012) |
| "The purpose of this study was to examine possible peripheral mechanisms for the reduction of propofol injection pain by the addition of ketamine." | 7.75 | Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol. ( Do, SH; Hwang, J; Jeon, YT; Lee, SC; Lim, YJ; Park, HP, 2009) |
| "We conclude that increased bitter taste sensitivity correlates with increased intensity or incidence of propofol injection pain and NRS of venepuncture pain." | 7.74 | Relation between bitter taste sensitivity and incidence or intensity of propofol injection pain. ( Basaranoglu, G; Delatioglu, H; Erden, V; Kiroglu, S; Korkut, Y; Yangin, Z, 2007) |
| " infusion of propofol, or propofol plus ketamine for deep sedation and analgesia was carried out in two patients with severe epidermolysis bullosa (EB) during extensive dressing changes and deep whirlpool baths." | 7.74 | Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa. ( Wu, J, 2007) |
| "Collectively our data suggest that propofol-evoked vascular pain is mainly initiated by prostanoids." | 7.73 | Characteristics of propofol-evoked vascular pain in anaesthetized rats. ( Ando, R; Watanabe, C, 2005) |
| "Incidence and intensity of pain on intravenous injection of propofol LCT were compared with those of propofol MCT/LCT." | 7.73 | [Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory]. ( Hoka, S; Inamura, M; Isono, M; Kanai, A; Kosaka, Y; Nakano, T; Nomiyama, S; Okamoto, H; Ozawa, A; Ueno, T, 2005) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 7.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| "In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry." | 7.71 | [Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain]. ( Dai, TJ; Duan, SM; Yan, M; Zhang, LC; Zheng, YM, 2002) |
| "The author studied the use of intravenous Propofol for the relief of pain." | 7.68 | [Changes in the pain produced by the peripheral venous injection of propofol when it is combined with lidocaine or fentanyl]. ( Croston, J; de Henriquez, L; de Jiménez, L; Espinosa, V, 1992) |
| "Pain on injection of three anaesthetic induction agents, thiopentone, methohexitone and propofol (diisopropyl phenol), administered into a vein on the dorsum of the hand or wrist, was studied in 32 premedicated patients undergoing elective surgery." | 7.67 | Pain on i.v. injection of propofol (ICI 35 868) in emulsion formulation. Short communication. ( Hynynen, M; Korttila, K; Tammisto, T, 1985) |
| "Assessment of pain on injection of the emulsified formulation of di-isopropylphenol (propofol, 'Diprivan') was undertaken in 120 unpremedicated patients and comparison made with thiopentone." | 7.67 | Assessment and modification of pain on induction with propofol (Diprivan). ( Lees, NW; McCulloch, MJ, 1985) |
| "Pain was severe in four dogs with Drug(PC)." | 6.77 | Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs. ( Brearley, JC; Leece, EA; Michou, JN, 2012) |
| "Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect." | 6.77 | Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012) |
| "Propofol-Lipuro has an oil phase that allows a larger proportion of propofol to be dissolved in it and, thereby, apparently reduces pain." | 6.71 | A comparison of pain on intravenous injection between two preparations of propofol. ( Irwin, MG; Sun, NCH; Wong, AYC, 2005) |
| "No patient had a headache or experienced postural hypotension." | 6.67 | Pain on injection of propofol: modification by nitroglycerin. ( Anderson, M; Gauntlett, IS; Wilkinson, D, 1993) |
| "injection pain was studied in 100 adult patients." | 6.66 | Effect of diluting propofol on the incidence of pain on injection and venous sequelae. ( Hutton, P; Robson, N; Stokes, DN, 1989) |
| "To evaluate the incidence and severity of injection pain caused by microemulsion propofol and lipid emulsion propofol in relation to plasma bradykinin generation and aqueous free propofol concentrations." | 6.24 | Pain on injection with microemulsion propofol. ( Jung, JA; Ki, KH; Lee, DH; Lee, SH; Noh, GJ; Park, DY; Sim, JY, 2009) |
| "To study the incidence of pain upon injection of 1% propofol (Propofol-Lipuro 1%, B." | 6.21 | [Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides]. ( Ayuso, MA; Fernández, J; Gomar, C; Luis, M; Sala, X, 2004) |
| "To determine whether the bispectral index (BIS) monitor could be used to guide physicians in titrating propofol to an effective safe level of deep sedation for children undergoing painful medical procedures." | 6.21 | Bispectral index as a guide for titration of propofol during procedural sedation among children. ( Kohli, SM; Nazarian, EB; Powers, KS; Rubenstein, JS; Sullivan, JS; Tapyrik, SA; van der Jagt, EW; Yin, H, 2005) |
| "Propofol is commonly used to induce general anesthesia; however, the pain caused during propofol injection is a disadvantage." | 5.69 | Deep breathing alleviates propofol-induced pain: a prospective, randomized, single-blind study. ( Hamada, T; Mori, T; Nishikawa, K; Tanaka, K; Yoshizumi, Y, 2023) |
| "Etomidate in combination with oxycodone for painless gastroscopic operation in the elderly is a safe and effective anesthetic strategy." | 5.69 | Safety and efficacy of etomidate in combination with oxycodone in painless gastroscopic procedures in the elderly: A prospective randomized controlled trial study. ( Li, YP; Zhou, Y, 2023) |
| "Anesthesia with rocuronium was associated with better intraoperative conditions and postoperative pain compared to anesthesia with remifentanil/propofol." | 5.69 | Paralysis Versus Non-Paralysis Anesthesia for Operative Laryngoscopy: A Randomized Controlled Trial. ( Amin, MR; Chen, S; Chin, WA; Crosby, T; Ezeh, UC; Kwak, PE; Patil, S; Yang, J, 2023) |
| "Regardless of the positive attributes of propofol, it is frequently associated with pain on injection." | 5.69 | Prevention of pain on injection of propofol using ice gel pack versus pre-treatment with lignocaine: a randomized controlled trial. ( Chauhan, R; Karki, Y; Luthra, A; Meena, SC; Sarna, R; Singh, N; Thappa, P, 2023) |
| "Ciprofol proved to be a safer alternative to propofol for anesthesia during hysteroscopy." | 5.69 | Efficacy and Safety of Ciprofol for Sedation/Anesthesia in Patients Undergoing Hysteroscopy: A Randomized, Parallel-Group, Controlled Trial. ( Dong, X; Duan, G; Jin, L; Lan, H; Mei, P; Shan, W; Wu, J; Wu, Y; Xu, Q; You, M, 2023) |
| " Combining esketamine with propofol (P + E) could reduce propofol consumption and injection pain." | 5.69 | Remimazolam versus propofol in combination with esketamine for surgical abortion: A double-blind randomized controlled trial. ( Chen, J; Li, N; Ma, X; Wan, Z; Wang, J; Yang, L; Yue, L, 2023) |
| " This study compared the effect of ciprofol and propofol on swallowing function during painless gastroenteroscopy." | 5.69 | Effect of ciprofol on swallowing function in patients undergoing painless gastrointestinal endoscopy. ( Dong, S; Liao, J; Lv, S; Wang, X; Ye, Y; Zeng, L; Zhang, Q, 2023) |
| " Pain score, parental satisfaction, the incidence of propofol rescue and negative postoperative behavioral changes (NPOBCs) were assessed." | 5.69 | Sucking lollipop after awakening from sevoflurane anesthesia reduces the degree of emergence agitation in children undergoing ambulatory surgery: A prospective randomized controlled trial. ( Huang, F; Mo, X; Wu, X; Zeng, J; Zhang, K, 2023) |
| "Propofol is a sedative and a hypnotic agent used in the induction and maintenance of general anesthesia." | 5.56 | Spastic Cerebral Palsy Pain Improvement With Propofol: A Case Report. ( Guichard, L; Lansaman, T; Martinez, V, 2020) |
| " Complications including apnea, hypotension, hypoxia, nausea, and vomiting, along with gastroenterologist satisfaction and patients' pain score (based on Wong-Baker faces pain assessment scale), were recorded by a checklist." | 5.51 | Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial. ( Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H, 2022) |
| "The results of this study showed that target-controlled plasma infusion of lidocaine can reduce propofol consumption in patients undergoing vocal cord polypectomy by supporting laryngoscopy, and the hemodynamics are more stable and reduce the coughing reaction in the wake period and throat pain after extubation without adverse events." | 5.51 | The effects of target-controlled infusion of lidocaine undergoing vocal cord polypectomy: A randomized controlled trial (CONSORT compliant). ( Bi, X; Cai, C; Hang, Q; Qi, Y; Wu, R; Zhou, L, 2022) |
| "8% for the difference between the groups, which met the predesigned criteria of > - 8%, confirming the non-inferiority of anesthesia/sedation produced by HSK3486 compared to propofol." | 5.51 | Efficacy and Safety of HSK3486 for Anesthesia/Sedation in Patients Undergoing Fiberoptic Bronchoscopy: A Multicenter, Double-Blind, Propofol-Controlled, Randomized, Phase 3 Study. ( Guo, Q; Li, Y; Luo, Z; Ouyang, W; Shangguan, W; Tu, H; Wang, X; Wang, Y; Wei, X; Wu, H; Zhang, X; Zhu, Z; Zou, X, 2022) |
| "The primary outcome was the efficacy of ondansetron compared to lidocaine and placebo for the reduction of propofol injection pain." | 5.51 | A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study. ( Chaofan, S; Kosem, R; Plansangkate, P; Tanasansuttiporn, J; Termthong, S; Wasinwong, W, 2022) |
| "The study was aimed to compare the efficacy and safety of different sedation protocols of dexmedetomidine-remifentanil and propofol-remifentanil for percutaneous closure of atrial septal defects (ASD) under transthoracic echocardiography (TTE) guidance." | 5.51 | Comparison of the efficacy and safety of sedation protocols with the use of dexmedetomidine-remifentanil and propofol-remifentanil during percutaneous closure of atrial septal defects: a randomized clinical trial. ( Chen, XL; Huang, WH; Zhang, GC; Zheng, YH, 2022) |
| "To investigate the comparison and clinical value of ciprofol and propofol for painless gastroenteroscopy anesthesia in terms of intraoperative adverse reactions, operation, resuscitation, and satisfaction of patients." | 5.51 | Comparison and Clinical Value of Ciprofol and Propofol in Intraoperative Adverse Reactions, Operation, Resuscitation, and Satisfaction of Patients under Painless Gastroenteroscopy Anesthesia. ( Chen, X; Guo, P; Liu, Z; Yang, L; Yu, D, 2022) |
| " The results showed that the dosage of sufentanil and propofol decreased significantly in the experimental group (P<0." | 5.48 | Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. ( Xie, M; Xie, S, 2018) |
| "Propofol-induced injection pain (PIP) is a well-known problem in general anesthesia." | 5.41 | Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial. ( Cao, H; Gong, X; Guan, X; Huang, X; Jiao, Z; Lan, H; Lin, C; Liu, S; Tan, Y; Xu, B, 2021) |
| " Current clinical studies have focused on the use of remimazolam and propofol for general anesthesia (GA) as indicators of safety outcomes in surgical patients, but different studies have reached different conclusions." | 5.41 | Comparison of remimazolam and propofol about safety outcome indicators during general anesthesia in surgical patients: a systematic review and meta-analysis. ( An, L; Bai, X; Chen, R; Gao, H; Huang, X; Tong, R; Wang, C; Wu, X; Yi, J; Zhang, Z, 2023) |
| " Propofol is the most widely used agent for induction of anesthesia and sedation by anesthesiologists." | 5.41 | Remimazolam ( Chang, Y; Chi, KY; Huang, YT, 2023) |
| "In non-intubated general anesthesia, the combination of subclinical doses of esketamine and propofol did reduce circulatory and respiratory depression, injection pain, and other adverse effects, while the incidence of esketamine's own side effects such as neuropsychiatric reactions did not increase, and the combination of the two did not cause the occurrence of new and more serious adverse reactions, and the combination of the two was safe and effective." | 5.41 | Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis. ( Chen, H; Ding, X; Fu, Q; Li, P; Liu, Q; Xiang, G; Xu, L, 2023) |
| "To determine the median effective dose (ED50) of prophylactic intravenous lidocaine for the prevention of propofol medium-chain triglyceride/long-chain triglyceride (MCT/LCT) emulsion injection pain." | 5.41 | Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight. ( Ma, R; Shan, Q; Sui, W; Tan, C; Tian, S; Xing, Z; Zhang, D; Zhang, Z; Zhou, W, 2021) |
| "The intensities of injection pain resulting from the use of long- and medium-chain triglyceride (LCT/MCT) propofol and conventional LCT propofol during esophagogastroduodenoscopy (EGD) have yet to be compared." | 5.41 | Pain Intensity at Injection Site during Esophagogastroduodenoscopy Using Long- and Medium-Chain versus Long-Chain Triglyceride Propofol: A Randomized Controlled Double-Blind Study. ( Cho, KB; Kim, ES; Lee, JS; Lee, JY; Lee, YJ; Park, KS, 2021) |
| "Pain is a common side effect of intravenous injection of propofol." | 5.41 | The Effect of Vibration on Pain During Intravenous Injection of Propofol: A Randomized Controlled Trial. ( Choice, C; Greige, N; Hwang, LK; Larios-Valencia, J; Nash, DW; Pothula, A; Yedlin, A, 2021) |
| " Patient characteristics, American Society of Anesthesiologists (ASA) classification, vital parameters and propofol dosage were registered on specially designed forms." | 5.37 | [Procedural sedation with propofol in non-painful interventions in children]. ( Bruijnen, CJ; Dijkman, KP; Halbertsma, FJ; Mohns, T; van Ooyen, F, 2011) |
| "Pretreatment with propofol significantly decreased writhing responses induced by visceral pain, suppressed the visceral pain-induced aspartate and glutamate release, and reversed the decreased release of γ-amino butyric acid in the cerebrospinal fluid." | 5.36 | Effects of anesthetic propofol on release of amino acids from the spinal cord during visceral pain. ( Fang, L; Liu, Y; Mu, X; Wang, Y; Wu, A; Wu, J; Yue, Y; Zhang, Y, 2010) |
| "We encountered two cases of acute pancreatitis in patients with Cushing's disease following transnasal transsphenoidal hypophysectomy." | 5.33 | Can propofol precipitate pancreatitis in patients with Cushing's syndrome? ( Bhagat, H; Chaturvedi, A; Goswami, R; Pandia, MP; Priya, G; Seth, A, 2005) |
| "Propofol was infused during PVP in eleven cancer patients after obtaining written informed consent." | 5.32 | [Use of propofol for painful procedures in cancer pain management]. ( Nakaho, T; Ohara, T; Takahashi, M; Yamamoto, Y; Yamamuro, M, 2003) |
| "To assess the factors associated with adenoma detection in propofol-sedated patients." | 5.30 | Factors Associated With Adenoma Detection in Propofol-sedated Patients. ( Dong, T; Hsieh, YH; Hu, CT; Jia, H; Koo, M; Leung, FW; Pan, Y; Tseng, CW; Zhang, L, 2019) |
| "Remifentanil was a μ-agonist, with a rapid onset, a powerful narcotic analgesic activity and a fast nonspecific esterases hydrolyzation and theoretically an ideal opioid for percutaneous dilatational tracheostomy (PDT)." | 5.30 | The use of remifentanil in critically ill patients undergoing percutaneous dilatational tracheostomy: A prospective randomized-controlled trial. ( Chang, SY; Feng, M; Liu, G; Sun, RQ; Wang, HL; Xu, DQ; Xu, YM, 2019) |
| "To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection." | 5.30 | Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial. ( Jongjidpranitarn, M; Nimmaanrat, S; Oofuvong, M; Prathep, S, 2019) |
| "Lidocaine alleviates propofol injection pain." | 5.27 | Intravenous Lidocaine Alleviates the Pain of Propofol Injection by Local Anesthetic and Central Analgesic Effects. ( Cai, J; Hei, Z; Liang, L; Luo, C; Xing, J; Zhou, S, 2018) |
| "Current analgesic strategies for propofol injection pain may cause adverse reactions during electroconvulsive therapy (ECT), such as shortening seizure duration." | 5.27 | Effect of dexmedetomidine for attenuation of propofol injection pain in electroconvulsive therapy: a randomized controlled study. ( Chen, CJ; Hei, ZQ; Li, X; Pan, JR; Tan, F; Xing, JB; Zhou, SL; Zhu, QQ, 2018) |
| "In this study, the aim was to investigate the effect of hyoscine N-butylbromide (HnBB) pretreatment on pain during propofol injection." | 5.27 | Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study. ( Aydoğan, E; Sargın, M; Uluer, MS, 2018) |
| "Pain on injection is a limitation with propofol use." | 5.27 | Evaluation of efficacy of Valsalva maneuver for attenuating propofol injection pain: a prospective, randomized, single blind, placebo controlled study. ( Agarwal, A; Dixit, A; Gautam, S; Khuba, S; Kumar, S; Yadav, M, 2018) |
| "Propofol causes injection pain." | 5.24 | Preventive effect of a vapocoolant spray on propofol-induced pain: a prospective, double-blind, randomized study. ( Kim, DH; Lee, MY; Moon, YE, 2017) |
| " Propofol with opioids has been recommended for gastroscopy sedation but the effects on cough reflex suppression remain unclear." | 5.24 | Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial. ( Cao, YZ; Lu, X; Xia, J; Xie, J; Yin, N; Yuan, J, 2017) |
| " Plasmatic remifentanil and propofol concentrations were similar in both groups either before tracheal intubation or during the 5 minutes following intubation." | 5.24 | Nociceptive stimulation during Macintosh direct laryngoscopy compared with McGrath Mac videolaryngoscopy: A randomized trial using indirect evaluation using an automated administration of propofol and remifentanil. ( Chazot, T; Dreyfus, JF; Fessler, J; Fischler, M; Ing, R; Le Guen, M; Liu, N, 2017) |
| "Propofol is associated with pain during injection, which is stressful to patients." | 5.24 | Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study. ( Jeon, Y; Kim, S; Kwon, T; Lee, M; Park, K, 2017) |
| "Administration of 300 mg MgSO4 plus 40 mg lidocaine reduces propofol injection pain very well." | 5.22 | Magnesium Sulfate Plus Lidocaine Reduces Propofol Injection Pain: A Double-blind, Randomized Study. ( Lin, W; Sun, J; Wang, W; Zhou, J; Zhou, R, 2016) |
| "Injection pain of propofol remains a common clinical problem." | 5.22 | Efficacy of different fluids preload on propofol injection pain: A randomized, controlled, double-blinded study. ( Lin, Y; Liu, Z; Luo, TY; Yuan, SY, 2016) |
| " Secondary end points were propofol dose, patient satisfaction and pain, colonoscopy quality indicators, and procedure and recovery times." | 5.22 | Non-anesthesiologist administration of propofol sedation for colonoscopy is safe in low risk patients: results of a noninferiority randomized controlled trial. ( Barjas, E; Cravo, M; Dias, S; Ferreira, AO; Ferreira, R; Glória, L; Nunes, J; Pereira, S; Rocha, M; Santos, AA; Torres, J, 2016) |
| "Lidocaine reduces pain that occurs upon the intravenous injection of propofol." | 5.22 | Comparison of the effects of lidocaine pre-administration and local warming of the intravenous access site on propofol injection pain: Randomized, double-blind controlled trial. ( Jeong, M; Yoon, H, 2016) |
| "To determine the most effective time interval between remifentanil and propofol (TimeRP) for the prevention of propofol injection pain in association with remifentanil dosage." | 5.22 | Impact of time interval between remifentanil and propofol on propofol injection pain. ( Chung, S; Jeong, S; Lee, HJ; Lee, SE; Lee, SH, 2016) |
| "Pretreatment with oral pregabalin 150 mg and intravenous lidocaine 40 mg with venous occlusion equally reduced pain from propofol injection." | 5.22 | Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection: A double-blind, randomized clinical consort study. ( Choi, E; Jeon, Y; Kim, D, 2016) |
| "The incidence of propofol injection pain is high in children, but no methods have been found to suppress it completely." | 5.20 | Preemptive dexmedetomidine to prevent propofol injection pain in children. ( Dong, C; Lu, Y; Yu, J; Zhang, Y, 2015) |
| "In this double-blind, placebo-controlled, randomized trial, the combination of intravenous magnesium sulfate and lidocaine offered no additional benefit for the relief of propofol injection pain compared to intravenous lidocaine alone." | 5.20 | Magnesium sulfate with lidocaine for preventing propofol injection pain: a randomized, double-blind, placebo-controlled trial. ( Galgon, RE; Groth, J; Heier, J; Schroeder, KM; Strube, P; Wang, S, 2015) |
| " The objective was to evaluate EMLA (eutectic mixture of local anesthetics) cream as a pain reliever in conjunction with propofol in the setting of routine lumbar punctures." | 5.20 | Topical analgesia treats pain and decreases propofol use during lumbar punctures in a randomized pediatric leukemia trial. ( Bazzell, S; Roe, DJ; Saboda, K; Whitlow, PG; Wilson, C, 2015) |
| "The results of this study suggest that nitrous oxide inhalation combined with propofol sedation attenuates the hypotensive effect and pain associated with propofol injections, along with potentiating the amnesic effect." | 5.20 | A prospective, randomized controlled trial of conscious sedation using propofol combined with inhaled nitrous oxide for dental treatment. ( Hanamoto, H; Kudo, C; Morimoto, Y; Niwa, H; Sugimura, M; Yokoe, C, 2015) |
| "We aimed to compare the effectiveness of esmolol 1 mg/kg and lidocaine 1 mg/kg for injection pain and for the prevention of rocuronium-induced withdrawal response." | 5.20 | Effects of pretreatment with esmolol and lidocaine on injection pain and rocuronium-induced withdrawal response. ( Akinci, M; Bumin Aydin, G; Ergil, J; Gürel, A; Kavak Akelma, F; Özkan, D, 2015) |
| "The aim of this study is to investigate the effects of propofol alone, propofol + remifentanil, and propofol + fentanyl combinations on the total dose of propofol to be administered during ERCP and on the pain scores after the process." | 5.20 | Comparison of Propofol, Propofol-Remifentanil, and Propofol-Fentanyl Administrations with Each Other Used for the Sedation of Patients to Undergo ERCP. ( Aydınlı, B; Bozkurt, E; Demir, B; Dişibeyaz, S; Haytural, C; Kazancı, D; Özgök, A; Parlak, E; Saraç, A, 2015) |
| "To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine." | 5.19 | Cisatracurium pretreatment with tourniquet reduces propofol injection pain: a double-blind randomized controlled trial. ( Kim, YH; Lim, CH; Namgung, J, 2014) |
| "5 mg/kg lidocaine with venous occlusion is recommended to prevent pain following injection of lipid emulsion propofol." | 5.19 | Intravenous lidocaine pretreatment with venous occlusion for reducing microemulsion propofol induced pain: comparison of three doses of lidocaine. ( Chae, YJ; Chang, HS; Joe, HB; Kim, DH; Kim, JA, 2014) |
| "Propofol injection pain is a common and unsolved anaesthesia problem." | 5.19 | Influence of polyvinyl chloride infusion extension tube on propofol injection pain: a randomised controlled study. ( Jia, Y; Lei, W; Shen, Y; Wu, Q; Zhang, N, 2014) |
| "One of the concerns in the use of propofol is the pain on injection of the drug." | 5.19 | [Effect of concentration on counting numbers on pain induced by injection of propofol]. ( Fujimoto, K; Kurahashi, K; Toh, M, 2014) |
| "The study was designed to investigate postoperative nausea and vomiting (PONV) in low- and high-dose remifentanil regimens for total intravenous anaesthesia (TIVA) in adult female patients with American Society of Anaesthesiologists physical status classification I undergoing local breast excision." | 5.19 | Total intravenous anaesthesia with high-dose remifentanil does not aggravate postoperative nausea and vomiting and pain, compared with low-dose remifentanil: a double-blind and randomized trial. ( Cho, MJ; Kim, SH; Oh, CS; Yang, JH; Yi, HR; Yoon, TG, 2014) |
| "The incidence of propofol-induced pain was significantly higher in the control group (39%) than in the other three groups (17% in the cooling group, 16% in the lidocaine group and 8% in the lidocaine plus cooling group)." | 5.19 | [Effectiveness of local cooling and lidocaine administration for prevention of pain upon injection of propofol]. ( Fujinaka, W; Takatori, M; Takubo, I; Terada, N, 2014) |
| "To examine whether dexmedetomidine reduces the injection pain of propofol and rocuronium and to investigate whether the decrease in injection pain is associated with the known sedative action of dexmedetomidine." | 5.19 | Dexmedetomidine reduces pain associated with rocuronium injection without causing a decrease in BIS values: a dose-response study. ( Baek, J; Joo, J; Lee, J, 2014) |
| "To evaluate the pain on injection of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy." | 5.19 | Comparing the pain of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy. ( Bao, Y; Shi, D; Zhang, L, 2014) |
| "The incidence of propofol injection pain during induction of general anesthesia varies from 28% to 90%." | 5.19 | Dexmedetomidine pretreatment alleviates propofol injection pain. ( He, L; He, T; Liu, L; Xu, JM; Zhu, R, 2014) |
| "Use of a new ultrathin colonoscope was associated with reduced propofol consumption, lower patient sedation levels, and less pain than the standard colonoscope, but ileal intubation time was longer." | 5.17 | Propofol sedation for colonoscopy with a new ultrathin or a standard endoscope: a prospective randomized controlled study. ( Goeser, T; Holzapfel, B; Lehmacher, W; Mertens, J; Neuhaus, H; Schumacher, B; Terheggen, G; Toermer, T; Töx, U, 2013) |
| "Propofol causes considerable pain upon injection, although different methods and propofol formulations have been used to decrease this pain." | 5.17 | Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain. ( Akgün Salman, E; Akpek, E; Arslan, G; Titiz, L, 2013) |
| "The aim of this study was to determine whether pretreatment with alkalinised lignocaine reduced the incidence and severity of pain during propofol injection." | 5.17 | Effect of alkalinisation of lignocaine for propofol injection pain: a prospective, randomised, double-blind study. ( Aydogan, MS; Begec, Z; Colak, C; Erdogan, MA; Ozgul, U; Sanli, M, 2013) |
| "Ketamine can completely eliminate pain associated with propofol injection." | 5.17 | An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study. ( Wang, M; Wang, Q; Wang, WS; Yu, YY, 2013) |
| "This prospective, double-blind, placebo-controlled study was designed to determine the efficacy of nitrous oxide (N(2)O) in alleviating the pain that followed sequential injection of propofol and rocuronium." | 5.17 | Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection. ( Kim, CH; Kim, E; Kim, HK; Kim, HY; Kwon, JY; Lee, DW, 2013) |
| "The goal of this study was to evaluate the effect of different methods of tourniquet application and lidocaine administration on MP injection pain." | 5.17 | Reducing the pain of microemulsion propofol injections: a double-blind, randomized study of three methods of tourniquet and lidocaine. ( Kim, HZ; Kim, K; Kim, NS; Kong, MH; Lee, DK; Lee, IO; Lim, BG; Sung Kim, Y, 2013) |
| "The addition of fentanyl 1 mcg/kg to propofol for brief painful procedures reduces movement, propofol dose, and recovery time." | 5.17 | Prospective randomized crossover evaluation of three anesthetic regimens for painful procedures in children with cancer. ( Anghelescu, DL; Burgoyne, LL; Faughnan, LG; Hankins, GM; Pui, CH; Smeltzer, MP, 2013) |
| "The lidocaine-ketamine combination is most effective for decreasing the pain on propofol injection." | 5.17 | A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection. ( Chaudhary, K; Gogia, AR; Gupta, P, 2013) |
| "Fifty patients with chronic alcoholism scheduled for elective ERCP were randomized 1:1 to receive dexmedetomidine (Dex group) (loading dose 1 μg kg(-1) over 10 min, followed by constant intravenous infusion 0." | 5.17 | Dexmedetomidine impairs success of patient-controlled sedation in alcoholics during ERCP: a randomized, double-blind, placebo-controlled study. ( Halttunen, J; Kylänpää, L; Lindström, O; Mazanikov, M; Mustonen, H; Pöyhiä, R; Udd, M, 2013) |
| " This study aimed to measure the incidence of propofol injection pain and evaluate the effect of lidocaine on pain caused during sedative upper GI endoscopic examinations." | 5.16 | Incidence of propofol injection pain and effect of lidocaine pretreatment during upper gastrointestinal endoscopy. ( Cho, KB; Chung, WJ; Hwang, JS; Jang, BK; Kim, ES; Kim, TY; Kwon, JS; Lee, JE; Park, KS; Park, WY, 2012) |
| "A significantly higher proportion of patients in the placebo group (83 %) experienced pain compared to the lidocaine and combination groups (43 and 7 %, respectively; both, P < 0." | 5.16 | Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine. ( Jeon, Y, 2012) |
| "To assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups." | 5.16 | Ondansetron pretreatment reduces pain on injection of propofol. ( Maleki, A; Rostami, G; Zahedi, H, 2012) |
| "To evaluate the efficacy of ketamine in preventing propofol injection pain in children." | 5.16 | Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine. ( Bao, SM; Guo, Y; Meng, LX; Zhang, LH; Zhao, GY, 2012) |
| "In a prospective double-blind study, 165 patients were randomized to use propofol or propofol with alfentanil as PCS combined with local anaesthetic for pain control." | 5.16 | Alfentanil and patient-controlled propofol sedation - facilitate gynaecological outpatient surgery with increased risk of respiratory events. ( Nilsson, A; Nilsson, L; Sjöberg, F; Ustaal, E, 2012) |
| "kg(-1) and lidocaine 20 mg mixture significantly reduced propofol pain when compared with control group." | 5.16 | Prevention of propofol injection pain in children: a comparison of pretreatment with tramadol and propofol-lidocaine mixture. ( Borazan, H; Et, T; Kececioglu, A; Otelcioglu, S; Sahin, O; Uluer, MS, 2012) |
| "02 mg, % 2 lidocaine 40 mg, metoclopramide 10 mg, and ketamine 100 microg/kg yields propofol induced pain 38%, 76%, 76%, and 58% respectively." | 5.16 | The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain. ( Aktay, M; Ozlü, O; Polat, R, 2012) |
| "Subclinical doses of pentazocine can be used in the painless egg retrieval, but the dose of propofol should be increased to reduce the body activity during the operation." | 5.15 | [Application of subclinical doses of pentazocine and propofol in painless vaginal egg retrieval]. ( Ding, H; Gu, MN; Liang, FG; Shi, YS; Zhou, W, 2011) |
| "The lidocaine/flurbiprofen axetil combination, compared with lidocaine 40 mg or flurbiprofen 50 mg, effectively reduces pain during the injection of propofol." | 5.15 | Efficacy of the lidocaine/flurbiprofen axetil combination for reducing pain during the injection of propofol. ( Fujii, Y; Itakura, M, 2011) |
| "Pain frequency was 90% in the saline group, whereas the frequencies were significantly lower in the lidocaine and methylene blue groups (26." | 5.15 | Pain on injection of propofol: a comparison of methylene blue and lidocaine. ( Akinci, SB; Aypar, Ü; Salman, AE; Salman, MA; Saricaoglu, F, 2011) |
| "Pretreatment with combination of small-dose ephedrine and lidocaine could reduce the incidence and intensity of propofol-induced pain and also result in more stable hemodynamic profile, but however, the combination of two drugs failed to work better in further reduction of pain." | 5.15 | The effect of combined ephedrine and lidocaine pretreatment on pain and hemodynamic changes due to propofol injection. ( Kayalha, H; Khezri, MB, 2011) |
| "The addition of 3% sevoflurane at the time of preoxygenation for 1 min along with routine use of lidocaine-tourniquet completely prevented pain upon propofol injection, whereas sevoflurane by itself provided similar analgesia to premixed lidocaine with propofol." | 5.15 | Sevoflurane to alleviate pain on propofol injection. ( Ali, MS; DeSousa, K, 2011) |
| " Pain on injection was compared between propofol in cyclodextrin and propofol in lipid using subject and observer assessments of pain rated at several different time points." | 5.15 | Propofol in a modified cyclodextrin formulation: first human study of dose-response with emphasis on injection pain. ( Egan, TD; Pace, NL; Shimode, N; Wallentine, CB, 2011) |
| "Rapid injection was less painful than after pretreatment with lidocaine 0." | 5.15 | Rapid injection of propofol reduces vascular pain and facilitates Laryngeal Mask Airway insertion. ( Inomata, S; Shimizu, T; Tanaka, M, 2011) |
| "The intravenous injection of microemulsion propofol to induce anaesthesia causes more intense and frequent pain than lipid emulsion propofol." | 5.15 | Reduction of microemulsion propofol-induced injection pain via target-controlled remifentanil infusion. ( Chae, YJ; Cho, HB; Kim, SM; Min, SK; Park, SK; Won, YJ, 2011) |
| "To determine whether adding ephedrine to propofol is as effective as adding lidocaine at reducing injection pain, and its effects on hemodynamics." | 5.14 | Admixture of ephedrine to offset side effects of propofol: a randomized, controlled trial. ( Austin, JD; Parke, TJ, 2009) |
| "A common drawback of propofol is pain on injection and lignocaine is commonly mixed with propofol to reduce the incidence and severity of this pain." | 5.14 | Prevention of propofol pain: a comparative study. ( Jayaraman, L; Sethi, M; Sethi, N; Sharma, S; Sood, J, 2009) |
| "The aim of this study was to compare the effectiveness of these 3 different techniques of flurbiprofen axetil administration in reducing pain on injection of propofol." | 5.14 | Pretreatment with flurbiprofen axetil, flurbiprofen axetil preceded by venous occlusion, and a mixture of flurbiprofen axetil and propofol in reducing pain on injection of propofol in adult Japanese surgical patients: a prospective, randomized, double-bli ( Fujii, Y; Itakura, M, 2009) |
| "Our study demonstrated that the combination treatment of two different analgesic modalities, alfentanil and lidocaine, could prevent the moderate and severe pain on propofol injection, and reduce the incidence of mild pain compared with each drug alone." | 5.14 | Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone. ( Kim, JS; Kim, JY; Kwak, HJ; Min, SK, 2009) |
| "We conducted a prospective randomized study to assess the effects of preceding lidocaine on the incidence and intensity of propofol-induced pain." | 5.14 | [Effects of the injection method of lidocaine on preventing injection pain during anesthesia induction by target controlled infusion with propofol]. ( Kajiyama, S; Okada, Y; Osawa, Y, 2009) |
| "To investigate the alleviation effect of vein pretreatment and granisetron/lidocaine combination on propofol injection-induced pain." | 5.14 | [Effects of granisetron/lidocaine combination on propofol injection-induced pain: a double-blind randomized clinical trial]. ( Lin, XM; Ma, YS; Zhou, J, 2009) |
| "5 mg kg(-1) for prevention of propofol induced pain." | 5.14 | Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol. ( Borazan, H; Erdem, TB; Kececioglu, M; Otelcioglu, S, 2010) |
| "The use of supplemental alfentanil with propofol for procedural sedation did not result in a difference in reported pain or recall immediately after the procedure." | 5.14 | Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department. ( Biros, MH; Gray, RO; Miner, JR; Stephens, D, 2009) |
| "The aim of this study was to compare the efficacy of intravenous pretreatment with fentanyl 50 microg, fentanyl 100 microg, and lidocaine 40 mg, preceded by venous occlusion, for reducing pain on injection of propofol in adult Japanese surgical patients." | 5.14 | A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients. ( Fujii, Y; Itakura, M, 2009) |
| "On the basis of a small number of case studies, IV propofol has been advocated for the treatment of chronic daily headache (CDH)." | 5.14 | The effect of single-dose propofol injection on pain and quality of life in chronic daily headache: a randomized, double-blind, controlled trial. ( Dick, BD; Gray, DP; Jamieson-Lega, KI; Rashiq, S; Simmonds, MK; Sobolev, IA; Stewart, BJ, 2009) |
| "Administration of ketamine 100 microg x kg(-1) immediately before propofol injection is a safe and effective method in preventing propofol injection pain." | 5.14 | Prevention of propofol injection pain with small-dose ketamine. ( Nikooseresht, M; Seifrabie, M; Zahedi, H, 2009) |
| " Each of the four propofol solutions was administered 88 times; of patients receiving Baxter propofol+saline, 74 (84%) had pain; when mixed with 2% lidocaine 45 (50." | 5.14 | Pain on injection from propofol may be avoided by changing its formulation. ( Alcover, J; Aldrete, JA; Johnson, SC; Montpetit, FH; Otero, P; Parietti, A; Quiroga, D; Torrieri, A, 2010) |
| "5 mg kg(-1) ketamine reduced the incidence and intensity of propofol injection pain, whereas 1." | 5.14 | Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M; Kimura, T; Taniguchi, S; Tojo, T, 2010) |
| "This prospective, double-blind and randomized study is designed to determine the effect of menstrual cycle on the injection pain of propofol." | 5.14 | Effect of menstrual cycle on the injection pain due to propofol. ( Ayoğlu, H; Başaran, M; Erdoğan, G; Hanci, V; Okyay, RD; Turan, IO; Yilmaz, M; Yurtlu, S, 2010) |
| "To investigate the effect of parecoxib pretreatment with venous occlusion on propofol injection pain." | 5.14 | Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study. ( Bala, I; Ghai, B; Makkar, JK; Wig, J, 2010) |
| "In this prospective, randomized, double-blind, controlled trial, our primary objective was to assess the effect of a 3 : 1 mixture of propofol and thiopental in reducing pain on injection in children." | 5.14 | The effect of a 3 : 1 volume mixture of propofol 1% and thiopental 2.5% in reducing the pain on injection of propofol in children. ( Ajala, AM; Blackwelder, B; Fahringer, DL; Goodwin, SR; Gurgis, FS; Warde, MK; Ye, G, 2010) |
| "Injection pain during propofol administration can be particularly distressing in children." | 5.14 | Does the newer preparation of propofol, an emulsion of medium/long chain triglycerides cause less injection pain in children when premixed with lignocaine? ( Krishna, HM; Nittala, A; Varghese, E, 2010) |
| "We compare patient-controlled sedation (PCS) and emergency physician-controlled sedation (EPCS) with respect to propofol requirements, depth of sedation, adverse events, recovery time, physician satisfaction, and patient satisfaction in emergency department (ED) patients requiring brief but painful procedures." | 5.14 | A randomized controlled trial comparing patient-controlled and physician-controlled sedation in the emergency department. ( Bell, A; Chu, K; Duncan, A; Greenslade, J; Lipp, T; Rothwell, S, 2010) |
| "During administration, propofol significantly decreased pain scores and areas of hyperalgesia and allodynia compared with both 10% Intralipid and saline (placebo-corrected mean Numerical Rating Scale score reduction by propofol: 38 +/- 28%)." | 5.14 | Analgesic and antihyperalgesic properties of propofol in a human pain model. ( Bandschapp, O; Berset, A; Filitz, J; Ihmsen, H; Koppert, W; Ruppen, W; Urwyler, A, 2010) |
| "The use of propofol often results in pain upon injection." | 5.14 | Propofol injection pain: is it still an issue? The effect of premedication. ( Adam, S; Dedic, A; Gommers, D; Van Bommel, J, 2010) |
| "To compare the efficacy of 2% lidocaine "timing" on alleviation of pain upon induction using propofol or etomidate." | 5.14 | Does lidocaine more effectively prevent pain upon induction with propofol or etomidate when given preemptively than when mixed with the drug? ( Brock, MF; Grace, BE; Groban, L; Hillegass, G; Houle, TT; Morley, B, 2010) |
| "Pain on injection limits the use of propofol in children." | 5.13 | Avoiding propofol injection pain in children: a prospective, randomized, double-blinded, placebo-controlled study. ( Boufroukh, D; Bringuier, S; Capdevila, X; Dadure, C; Hocquet, AF; Lubrano, JF; Raux, O; Rochette, A, 2008) |
| "The overall incidence of pain on injection was 31/133 (23%) in the propofol-MCT/LCT plus lidocaine group vs." | 5.13 | Does addition of lidocaine to medium- and long-chain triglyceride propofol emulsions significantly reduce pain on injection? ( Jamjamrat, G; Kosittanasan, S; Krobbuaban, B; Kumkeaw, S; Siriwan, D; Tanomsat, M; Thanetses, K, 2008) |
| "To study the effect of the venous occlusion duration using lidocaine on the incidence and severity of propofol induced pain." | 5.13 | Duration of venous occlusion with lidocaine for preventing propofol induced pain. ( Abu-Ali, HM; Al-Ghanem, SA; Ammari, BA; Badran, IZ; Daradkeh, SS; Massad, IM, 2008) |
| " With respect to pain intensity, mean pain score was significantly less in the combination group than in the lidocaine or dexamethasone groups (P<0." | 5.13 | Efficacy of combination intravenous lidocaine and dexamethasone on propofol injection pain: a randomized, double-blind, prospective study in adult Korean surgical patients. ( Ha, J; Jeon, Y; Kim, Y; Kwak, KH, 2008) |
| "During the first 12 hr following the procedures, patients experienced significantly less vomiting/retching and less disruption of activity while receiving ondansetron, and recorded significantly lower pain scores while receiving fentanyl." | 5.13 | Pediatric oncology sedation trial (POST): A double-blind randomized study. ( Barr, RD; Buckley, N; Korz, L; Lappan, J; Nagel, K; Willan, AR, 2008) |
| "We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro." | 5.13 | Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine. ( Ahmad, N; Balan, S; Zanariah, Y, 2008) |
| " acetaminophen seems to be effective in attenuating pain during i." | 5.13 | Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain. ( Arun, O; Canbay, O; Celebi, N; Karagöz, AH; Ozgen, S; Saricaoğlu, F, 2008) |
| "Propofol produces anaesthesia with rapid recovery but also causes pain or discomfort on injection." | 5.13 | Prevention of propofol-induced injection pain by sufentanil: a placebo-controlled comparison with remifentanil. ( Honarmand, A; Safavi, M, 2008) |
| "The aim of this study was to compare the efficacy of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients." | 5.13 | Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study. ( Fujii, Y; Itakura, M, 2008) |
| "A research was performed to review the effect of pharmacological interventions to control the propofol injection pain." | 5.12 | Pharmacological control of pain during propofol injection: a systematic review and meta-analysis. ( Bakhtiari, E; Gharavi Fard, M; Mousavi, SH, 2021) |
| "Incidence and intensity of pain on intravenous injection of propofol were assessed with emulsion of long-chain/medium-chain triglycerides (LCT/MCT, 50: 50) and only long-chain triglycerides (LCT, 100) in patients undergoing different elective surgical interventions in this prospective, randomized, cross over and double-blinded study." | 5.12 | [The injection pain of propofol with different emulsion]. ( Kinoshita, M; Morioka, N; Ozaki, M; Takada, M, 2006) |
| "A basal infusion of remifentanil plus remifentanil patient controlled analgesia and target controlled infusion of propofol were adequate but not optimal techniques for sedation/analgesia for radio frequency treatment of atrial flutter." | 5.12 | Remifentanil versus propofol for radio frequency treatment of atrial flutter. ( Arnulf, JJ; Balarac, N; Lena, P; Mariottini, CJ; Martin, R; Mihoubi, A, 2006) |
| "Propofol is a widely used intravenous anesthetic although its injection pain is a common and unpleasant problem." | 5.12 | Propofol formulated with long-/medium-chain triglycerides reduces the pain of injection by target controlled infusion. ( Andoh, T; Miyazaki, H; Suzuki, H; Yamada, Y, 2006) |
| "To evaluate the effects of clonidine and ephedrine on propofol-induced pain and on hemodynamic changes during the induction sequence." | 5.12 | Clonidine-ephedrine combination reduces pain on injection of propofol and blunts hemodynamic stress responses during the induction sequence. ( Fukushima, H; Furuya, A; Ishiyama, T; Kashimoto, S; Kumazawa, T; Oguchi, T, 2006) |
| "Previous studies found that lidocaine addition to propofol long-chain triglyceride was associated with a lower incidence of injection pain than medium-chain triglyceride/long-chain triglyceride formulation, but the incidence was still high (31-40%)." | 5.12 | Preventing pain during injection of propofol: effects of a new emulsion with lidocaine addition. ( Bachmann-Mennenga, B; Boedeker, RH; Heesen, M; Mann, M; Mühlenbruch, B; Ohlmer, A, 2007) |
| "Of the 4 methods studied, the optimal method to decrease the incidence and intensity of pain resulting from propofol injection is to inject lidocaine while applying venous occlusion for 60 seconds prior to administering propofol." | 5.12 | Venous occlusion with lidocaine for preventing propofol induced pain. A prospective double-blind randomized study. ( Abu-Ali, HM; Abu-Halaweh, SA; Badran, IZ; Massad, IM, 2006) |
| "Propofol is associated with a high incidence of injection pain in children, even if given together with lidocaine." | 5.12 | Etomidate-Lipuro is associated with considerably less injection pain in children compared with propofol with added lidocaine. ( Eksborg, S; Lönnqvist, PA; Nyman, Y; Palm, C; Von Hofsten, K, 2006) |
| "This study was undertaken to examine the influence of age on flurbiprofen axetil requirements for the treatment of propofol-induced pain on injection in Japanese adult surgical patients." | 5.12 | Influence of age on flurbiprofen axetil requirements for preventing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, vehicle-controlled, parallel-group, dose-ranging study. ( Fujii, Y; Nakayama, M, 2006) |
| "The present report evaluates the incidence of pain on intravenous injection and the condition of tracheal intubation at one minute following the administration of cisatracurium or rocuronium versus rocuronium-cisatracurium combination." | 5.12 | Cisatracurium or rocuronium versus rocuronium-cisatracurium combination. ( Baraka, A; Maaliki, H; Nahle, N; Zeidan, A, 2006) |
| "We examined the effect of lidocaine pretreatment before propofol administration on the incidence of transient motor disturbances and on propofol requirements for anesthesia induction in infants and children undergoing repeated painful diagnostic and therapeutic hematological procedures." | 5.12 | Lidocaine pretreatment for the prevention of propofol-induced transient motor disturbances in children during anesthesia induction: a randomized controlled trial in children undergoing invasive hematologic procedures. ( Annino, L; Bilotta, F; Favaro, R; Ferri, F; Rosa, G; Soriano, SG, 2006) |
| "Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection." | 5.12 | Small-dose ketamine reduces the pain of propofol injection. ( Cho, SJ; Ham, KD; Hwang, JH; Kim, YK; Koo, SW, 2006) |
| "To evaluate the influence of aging on lidocaine requirements for propofol-induced pain on injection." | 5.12 | Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "Propofol has a high incidence of pain on injection, particularly when a vein on the back of hand is used." | 5.12 | Prevention of pain on injection of propofol: a comparison of remifentanil with alfentanil in children. ( Al-Mujadi, H; Al-Qattan, AR; Batra, YK; Marzouk, HM; Petrova Ivanova, M; Rahman Al-Refai, A, 2007) |
| "Pain on injection is still a major problem with propofol; metoclopramide effectively decreases this pain." | 5.12 | Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "Pain on injection of propofol in children has been reported to be as high as 30-80%." | 5.12 | Effect of a 0.5% dilution of propofol on pain on injection during induction of anesthesia in children. ( Boulaadass, S; Gräf, G; Mencke, T; Molter, GP; Silomon, M; Soltész, S, 2007) |
| "Previous injection of diphenhydramine with venous occlusion can be considered as an alternative to lidocaine for reducing the prevalence of pain caused by injection of propofol into peripheral veins." | 5.12 | Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study. ( Apiliogullari, B; Apiliogullari, S; Balasar, M; Duman, A; Keles, B; Yilmaz, H, 2007) |
| "This prospective, double-blind, randomized, placebo-controlled study was designed to determine the efficacy of dexmedetomidine compared with lidocaine in reducing the pain of propofol and rocuronium injection pain." | 5.12 | Does dexmedetomidine reduce the injection pain due to propofol and rocuronium? ( Altunkaya, H; Ayoğlu, H; Cukdar, G; Ozer, Y; Ozkoçak, I; Yapakçi, O, 2007) |
| "35 microg kg(-1) min(-1)) and a premixture of lidocaine with propofol (mixture of propofol 1% and lidocaine 1% in a 10:1 ratio) was compared with either treatment alone in the prevention of pain on propofol injection." | 5.12 | Reduction of pain on injection of propofol: combination of pretreatment of remifentanil and premixture of lidocaine with propofol. ( Baek, W; Jeon, Y; Kim, J; Kim, S; Kwak, K; Lim, D; Park, S, 2007) |
| "We conducted this randomized double-blind trial to determine the extent of further pain reduction by adding lidocaine to Lipuro propofol." | 5.12 | Lidocaine is more efficient than the choice of propofol formulations to reduce incidence of pain on induction. ( Elliot, SC; Krishnan, K; Mallick, A; Vucevic, M, 2007) |
| "Pain at the site of intravenous injection of propofol is a common clinical finding." | 5.12 | Sustained intravascular exposure to propofol does not prolong pain at the site of injection. ( Akeson, J; Karlsson, A; Lagerkranser, M; Liljeroth, E, 2007) |
| "Local pain on injection of propofol remains a considerable problem in clinical anaesthesiology." | 5.12 | Low-dose propofol reduces the incidence of moderate to severe local pain induced by the main dose. ( Akeson, J; Karlsson, A; Lagerkranser, M; Liljeroth, E, 2007) |
| " The aim of the current study was to evaluate the potential of somatosensory (SSEP) and intracutaneous pain evoked (iSEP) potentials during remifentanil and propofol anesthesia as electroencephalographic indicators of the nociceptive blockade." | 5.12 | Identification of sensory blockade by somatosensory and pain-induced evoked potentials. ( Bischoff, P; Debener, S; Engel, A; Müller, J; Nitzschke, R; Scharein, E; Schmidt, GN; Siegel, M, 2007) |
| "The combination of two different analgesic modalities, remifentanil and lidocaine completely abolishes moderate and severe pain associated with propofol injection, and significantly reduces the incidence of mild pain when compared with each drug used alone." | 5.12 | Multimodal analgesia to prevent propofol-induced pain: pretreatment with remifentanil and lidocaine versus remifentanil or lidocaine alone. ( Al-Alami, AA; Aouad, MT; Baraka, AS; Siddik-Sayyid, SM, 2007) |
| "7%) complained of pain in the lidocaine plus remifentanil group compared with 15 (35." | 5.12 | A combination of lidocaine (lignocaine) and remifentanil reduces pain during propofol injection. ( Choi, G; Chung, H; Han, C; Jeon, Y; Kim, S; Kwak, K; Lim, C; Lim, D, 2007) |
| "Injection pain was twice as common with ketamine-propofol admixture than with lidocaine-propofol admixture." | 5.12 | A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture. ( Abdelaziz, AB; Cherif, R; Chettaoui, O; Kaabachi, O; Kokki, H; Ouezini, R, 2007) |
| "Flurbiprofen axetil emulsion (FA), a prodrug of nonsteroidal anti-inflammatory drugs (NSAIDs) that is widely used for perioperative pain relief in Japan, has been effective for reducing propofol injection pain, but the mechanism is unclear." | 5.12 | Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration. ( Kaminoh, Y; Tanimoto, M; Tashiro, C; Tatara, T; Tsujimoto, S; Ueki, R, 2007) |
| "Pain on injection is a recognized adverse event (AE) with propofol, an agent used to induce general anesthesia in surgical patients." | 5.12 | Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients. ( Fujii, Y; Nakayama, M, 2007) |
| "The incidence of pain on injection of propofol MCT/LCT was not different from that caused by propofol LCT with pretreatment of lidocaine and the intensity of pain on propofol MCT/LCT injection decreased significantly when using lidocaine pretreatment." | 5.12 | Pain on injection of propofol: propofol LCT vs propofol MCT/LCT with or without lidocaine pretreatment. ( Burimsittichai, R; Charuluxananan, S; Kumwilaisuk, K; Premsamran, P; Sathapanawath, N; Tingthanathikul, W, 2006) |
| "To determine whether a small dose of propofol before induction decreases pain with injection using two different formulas of propofol-10% long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) and LCT." | 5.12 | Evaluation of low-dose propofol preadministration to attenuate vascular pain during induction of anesthesia. ( Kodaka, M; Koyama, K; Maeyama, A; Miyao, H; Okuyama, S, 2007) |
| "Pain on injection of propofol is unpleasant." | 5.12 | Reduction of pain during induction with target-controlled propofol and remifentanil. ( Jung, CW; Lee, JR; Lee, YH, 2007) |
| "Propofol, a commonly used anesthetic, often causes pain on injection." | 5.12 | Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine. ( Boker, A; Ertok, E; Saadawy, I, 2007) |
| "Propofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) that have been reported to reduce injection pain." | 5.12 | A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection. ( Boonthom, N; Chalacheewa, T; Jommaroeng, P; Rungsithiwan, W; Sundarathiti, P, 2007) |
| "The authors used positron emission tomography to measure the effect of various concentrations of propofol on pain-evoked changes in regional cerebral blood flow." | 5.11 | Dose-dependent effects of propofol on the central processing of thermal pain. ( Backman, SB; Bushnell, MC; Fiset, P; Hofbauer, RK; Plourde, G, 2004) |
| "Pain on injection caused by Propofol-LCT with pre-treatment of lidocaine and Propofol-MCT/LCT alone is shown to be equivalent." | 5.11 | [Propofol-LCT versus propofol-MCT/LCT with or without lidocaine - a comparison on pain on injection]. ( Haaf-Von-Below, S; Kuhlen, R; Kunitz, O; Lösing, R; Rossaint, R; Schulz-Stübner, S, 2004) |
| "Intravenous magnesium and lidocaine pretreatment are equally effective in attenuating propofol-induced pain." | 5.11 | Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified. ( Agarwal, A; Dhiraj, S; Gupta, D; Pandey, CK; Pandey, R; Raza, M; Singh, PK; Singh, U, 2004) |
| "Propofol causes pain on IV injection in 28%-90% of patients." | 5.11 | Pretreatment with thiopental for prevention of pain associated with propofol injection. ( Agarwal, A; Ansari, MF; Dhiraj, S; Gupta, D; Pandey, R; Raza, M; Singh, PK; Singh, U, 2004) |
| " The mean total dose of propofol needed in this group was higher, but the patients had a tendency to rate the global tolerance and the pain of the examination as less comfortable compared to the two randomized groups." | 5.11 | Patient-controlled versus nurse-administered sedation with propofol during colonoscopy. A prospective randomized trial. ( Beglinger, C; Drewe, J; Heuss, LT; Pflimlin, E; Schnieper, P; Tapparelli, CB, 2004) |
| "Propofol causes pain or discomfort on injection in 28%-90% of patients." | 5.11 | Pain during injection of propofol: the effect of prior administration of butorphanol. ( Agarwal, A; Dhiraaj, S; Gupta, D; Pandey, CK; Pandey, R; Raza, M; Singh, PK; Singh, U, 2004) |
| " In order to evaluate if light propofol anesthesia in the pediatric oncology ward (POW) could improve the management of procedure pain and anxiety, a questionnaire was developed." | 5.11 | Propofol or propofol--alfentanil anesthesia for painful procedures in the pediatric oncology ward. ( Bredlöv, B; Olsson, GL; Söderhäll, S; Von Heijne, M, 2004) |
| "Propofol is well known for its association with pain on injection." | 5.11 | Propofol-induced injection pain: comparison of a modified propofol emulsion to standard propofol with premixed lidocaine. ( Adam, S; Dirckx, M; Jonsson, D; Klein, J; Pelka, M; van Bommel, J, 2004) |
| "We investigated the early recovery characteristics and pain relief of adult patients during combined anesthesia with (epidural and general), either with propofol or sevoflurane for maintenance in major abdominal surgery." | 5.11 | Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief. ( Duru, S; Elar, Z; Hepağuşlar, H; Ozkardeşler, S; Ozzeybek, D; Taşdöğen, A, 2004) |
| "5 mg, 5 mg, 10 mg) for reducing pain on injection of propofol in 100 patients scheduled for elective surgery." | 5.11 | Effect of metoclopramide on pain on injection of propofol. ( Fujii, Y; Uemura, A, 2004) |
| "Propofol causes pain on intravenous injection in 28 to 90% of patients." | 5.11 | Pain during injection of propofol: the effect of prior administration of ephedrine. ( Agarwal, A; Dhiraaj, S; Gupta, D; Ranjan, R; Raza, M; Singh, PK; Singh, U; Singhal, V, 2004) |
| "A common drawback of propofol is pain on injection and lidocaine is commonly mixed with propofol to reduce its incidence and severity." | 5.11 | Comparison of Propofol-Lipuro with propofol mixed with lidocaine 10 mg on propofol injection pain. ( Abdul-Latif, MS; Kam, E; McCluskey, A, 2004) |
| "The incidence of pain on injection of propofol has been reported to be 70%." | 5.11 | Pain on injection: a double-blind comparison of propofol with lidocaine pretreatment versus propofol formulated with long- and medium-chain triglycerides. ( Kern, C; Landau, R; Schaub, E, 2004) |
| "To compare the efficacy of alfentanil, remifentanil, and saline in minimizing the propofol injection pain." | 5.11 | The effects of alfentanil or remifentanil pretreatment on propofol injection pain. ( Balkan, BK; Ellidokuz, H; Gökel, E; Günerli, A; Iyilikci, L, 2004) |
| "In a randomized, double-blind, controlled trial, 120 ASA 1 or 2 patients were allocated to receive diclofenac or normal saline as pretreatment to assess their effect on incidence and severity of pain during propofol injection." | 5.11 | Effect of diclofenac pretreatment on pain during propofol injection. ( Agarwal, D; Mohta, M; Sandhu, K; Sethi, AK, 2004) |
| "We studied the effect of propofol, a widely used sedative-hypnotic drug, on pain perception." | 5.11 | The effect of propofol on thermal pain perception. ( Frölich, MA; Heft, MW; Price, DD; Robinson, ME; Shuster, JJ; Theriaque, DW, 2005) |
| "A randomized double-blind study compared two methods of preventing the pain from injection of propofol, lignocaine pre-treatment followed by propofol and lignocaine added to propofol." | 5.11 | Preventing pain on injection of propofol: a comparison between lignocaine pre-treatment and lignocaine added to propofol. ( Lee, P; Russell, WJ, 2004) |
| "In the burns group, significantly greater BIS values relating to increasing propofol TCI were noted at deeper anesthesia when compared with controls; at > or =3." | 5.11 | The relationship between bispectral index and targeted propofol concentration is biphasic in patients with major burns. ( Han, KW; Han, TH; Kil, HY; Kim, KM; Kwak, IS; Lee, JH, 2005) |
| "Local pain at the site of intravenous (iv) injection of propofol remains a considerable problem in clinical anaesthesiology, and particularly so in infants." | 5.11 | Less local pain on intravenous infusion of a new propofol emulsion. ( Akeson, J; Liljeroth, E, 2005) |
| " We studied its efficacy in decreasing the pain associated with IV administration of propofol and compared it with mixing lidocaine with propofol." | 5.11 | Bacteriostatic saline containing benzyl alcohol decreases the pain associated with the injection of propofol. ( Minogue, SC; Sun, DA, 2005) |
| "This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol." | 5.11 | Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005) |
| "25 patients (83%) complained of pain in the placebo group, compared with 12 (40%) in the lidocaine group (P < 0." | 5.11 | A lidocaine/metoclopramide combination decreases pain on injection of propofol. ( Fujii, Y; Nakayama, M, 2005) |
| " lidocaine and nitrous oxide (N2O) in oxygen (O2) inhalation pre-treatment was compared with either treatment alone in the prevention of pain on propofol injection." | 5.11 | A combination of lidocaine and nitrous oxide in oxygen is more effective in preventing pain on propofol injection than either treatment alone. ( Elsaigh, I; Galvin, E; Harmon, D; Leonard, I; Niazi, A; Wahid, Z, 2005) |
| "A new MCT-LCT propofol formulation as a plain solution was associated with a higher incidence of injection pain than LCT propofol with added lidocaine when used for induction of anaesthesia in children." | 5.11 | Propofol injection pain in children: a prospective randomized double-blind trial of a new propofol formulation versus propofol with added lidocaine. ( Eksborg, S; Georgiadi, A; Lönnqvist, PA; Nyman, Y; von Hofsten, K, 2005) |
| "Propofol formulated in medium- and long-chain triglycerides (MCT/LCT) is thought to cause less pain on injection." | 5.11 | The effects of intravenous lidocaine on pain during injection of medium- and long-chain triglyceride propofol emulsions. ( Chong, SY; Goh, MH; Tan, KH; Yew, WS, 2005) |
| "In a randomized, double-blind, prospective trial we compared the efficacy of pre-treatment with nitrous oxide (with or without premixed lignocaine in propofol) for the prevention of propofol-induced pain." | 5.11 | Effect of nitrous oxide in reducing pain of propofol injection in adult patients. ( Neema, PK; Rathod, RC; Sinha, PK, 2005) |
| "The present study was undertaken to examine the efficacy of flurbiprofen axetil for reducing pain on propofol injection in Japanese adult surgical patients." | 5.11 | Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients. ( Fujii, Y; Shiga, Y, 2005) |
| "Pain on injection of propofol continues to be a problem for anesthesiologists." | 5.11 | Pain on injection of lipid-free propofol and propofol emulsion containing medium-chain triglyceride: a comparative study. ( Dubey, PK; Kumar, A, 2005) |
| "The numbers of patients with severe and mild pain were larger in the order: LCT group (10 and 31 patients, respectively) > flurbiprofen 1 group (3 and 19) > or = MCT/LCT group (1 and 14) > or = lidocaine group (2 and 11) > flurbiprofen group (0 and 0)." | 5.11 | How to decrease pain at rapid injection of propofol: effectiveness of flurbiprofen. ( Nishiyama, T, 2005) |
| "To investigate the correlation among the level of anxiety, the intravenous propofol requirement for conscious sedation, and recovery profile in in vitro fertilization patients." | 5.11 | Comparison of conscious sedation for oocyte retrieval between low-anxiety and high-anxiety patients. ( Hong, JY; Jee, YS; Luthardt, FW, 2005) |
| "Pain on injection, reported in 28-90% of patients, is one of the most described side effects of the intravenous application of propofol." | 5.11 | Comparison on pain on injection of a small particle size-lipid emulsion of propofol and standard propofol with or without lidocaine. ( Diregpoke, S; Krobbuaban, B; Kumkeaw, S; Tanomsat, M, 2005) |
| " 15 and 30 mg ketorolac reduces pain following propofol injection." | 5.10 | Effect of pretreatment with ketorolac on propofol injection pain. ( Buerkle, H; Chou, AK; Huang, YW; Lee, TH; Lin, CR; Lin, SH; Lu, CY; Muhammad, R; Yang, LC, 2002) |
| "5 mg neostigmine (Group N, n = 35), 1 ml 2% lidocaine (Group L, n = 35), or 1 ml normal saline (Group C, n = 35) as pretreatment to reduce pain on propofol injection." | 5.10 | Can neostigmine reduce propofol injection pain? ( Chang, DP; Mok, MS; Pang, WW; Wang, CS; Yeh, M, 2002) |
| "48 mmol, injected 20 s before the administration of propofol significantly reduced the incidence of pain caused by a propofol injection and may be useful in minimizing this common side effect." | 5.10 | The use of magnesium sulfate to prevent pain on injection of propofol. ( Karamanlioğlu, B; Memiş, D; Pamukçu, Z; Süt, N; Turan, A, 2002) |
| "Although it is well-known that 2% lidocaine has an effective action for preventing propofol-induced pain, it has been unclear whether or not lidocaine of the concentration below 2% has the effective action similar to 2% lidocaine." | 5.10 | [Effects of concentration and dosage of lidocaine on preventing the pain on injection of propofol]. ( Adachi, H; Harada, T; Hirosawa, J; Inagaki, Y; Ishibe, Y; Otsuki, A; Tsubokura, H, 2002) |
| "One hundred seventy-six patients (ASA physical status I or II) presenting for elective surgery were randomly allocated into six study groups to compare the incidence of propofol-induced pain after pretreatment with different doses of ephedrine as compared with lidocaine." | 5.10 | Ephedrine reduces the pain from propofol injection. ( Cheong, MA; Choi, WJ; Kim, KS, 2002) |
| "To investigate if 50% nitrous oxide reduces the pain during injection of propofol mixed with lidocaine in children." | 5.10 | In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine. ( Beh, T; Kim, J; Splinter, W, 2002) |
| "The pain and distress ratings of patients undergoing BMAs (n = 73) and LPs (n = 105) were examined in a comparison of 3 different interventions: (1) a topical eutectic mixture of lidocaine and prilocaine (EMLA cream), (2) oral midazolam and EMLA cream, or (3) propofol/fentanyl general anesthesia." | 5.10 | Pain and distress from bone marrow aspirations and lumbar punctures. ( Doran, NH; Frost, JD; Holdsworth, MT; Mathew, P; Moro, MA; Pankey, JM; Phillips, J; Raisch, DW; Winter, SS, 2003) |
| "Pain on injection occurred in 9% and 21% of patients after propofol 1% and 2%, respectively (P=0." | 5.10 | Propofol 1% versus propofol 2% in children undergoing minor ENT surgery. ( Borgeat, A; Dumont, L; Lysakowski, C; Pellégrini, M; Tassonyi, E, 2003) |
| " Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14-52%, P = 0." | 5.10 | Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. ( Harmon, D; Lowe, D; Rozario, C, 2003) |
| "25 microg x kg(-1) x min(-1) with 40 mg lidocaine and placebo in the prevention of injection pain due to intravenous propofol administration (1." | 5.10 | Prevention of propofol-induced injection pain by remifentanil: a placebo-controlled comparison with lidocaine. ( Boldt, J; Maleck, WH; Piper, SN; Roehm, KD, 2003) |
| "The purpose of this prospective study was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy." | 5.10 | Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia. ( Kararmaz, A; Kaya, S; Ozyilmaz, MA; Turhanoglu, S, 2003) |
| "Pain is often experienced when propofol is injected, and intravenous lidocaine is often effective in preventing such pain." | 5.10 | Pain on injection of propofol: comparison of metoprolol with lidocaine. ( Aşik, I; Gülay, I; Tulunay, M; Yörükoğlu, D, 2003) |
| "We assessed the effectiveness of a 5-microm filter in reducing propofol-induced pain and determined whether any reduction is due to removal of contaminants or an alteration in flow characteristics." | 5.10 | A 5-microm filter does not reduce propofol-induced pain. ( Barry, J; Brimacombe, J; Hellier, C; Newell, S, 2003) |
| "Lidocaine is used to reduce pain associated with propofol injection, either mixed with propofol or preceding it as a separate injection." | 5.10 | The effect of mixing lidocaine with propofol on the dose of propofol required for induction of anesthesia. ( Hwang, NC; Tan, LH, 2003) |
| " Patients in the PCS group had significantly higher pain scores and significantly more recall than those in the midazolam and pethidine group." | 5.10 | Patient-controlled sedation for colonoscopy: a randomized trial comparing patient-controlled administration of propofol and alfentanil with physician-administered midazolam and pethidine. ( Bright, E; Dalgleish, D; Elliott, J; Kimble, J; Roseveare, C; Shepherd, H, 2003) |
| "Topical anesthesia using 60% lidocaine tape reduces the incidence of propofol injection pain." | 5.10 | The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol. ( Currer, BA; McCluskey, A; Sayeed, I, 2003) |
| "In patients having short painful surgery, less propofol does not give faster recovery as long as the same anaesthetic level (as indicated by BIS and clinical signs) is maintained by more remifentanil." | 5.10 | Early recovery after remifentanil-pronounced compared with propofol-pronounced total intravenous anaesthesia for short painful procedures. ( Detsch, O; Hackner, C; Jelen-Esselborn, S; Kochs, E; Schneider, G, 2003) |
| "To assess incidence and intensity of pain on intravenous injection of propofol (CAS 2078-548) in an emulsion of medium-chain/long-chain triglycerides (MCT/LCT, 50:50) in patients undergoing different elective surgical interventions." | 5.10 | Incidence of pain after intravenous injection of a medium-/long-chain triglyceride emulsion of propofol. An observational study in 1375 patients. ( Bachmann-Mennenga, B; Heesen, M; Ohlmer, A, 2003) |
| "The incidence of pain of the infusion was significantly lower in patients pretreated with ketamine (8% vs 37%, P = 0." | 5.10 | Pretreatment with intravenous ketamine reduces propofol injection pain. ( Barbi, E; Gagliardo, A; Gerarduzzi, T; Marchetti, F; Neri, E; Sarti, A; Ventura, A, 2003) |
| "Propofol is commonly used for induction and maintenance of anesthesia, but the pain during injection of propofol remains a clinical problem." | 5.10 | [Nicorandil reduces incidence and severity of pain on propofol injection]. ( Iwasaki, T; Shimizu, Y; Takasaki, M; Yoshimura, Y, 2003) |
| "The purpose of this study was to evaluate the effect of pre-treatment with ketamine on the reduction of pain during injection of propofol in adult patients." | 5.10 | [Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection]. ( Kumazawa, T; Masamune, T; Nonaka, A; Suzuki, S, 2002) |
| "To compare the efficacy of tramadol and ondansetron in minimizing the pain due to injection of propofol in 100 patients." | 5.10 | The prevention of propofol injection pain by tramadol or ondansetron. ( Karamanlioglu, B; Kaya, G; Memiş, D; Pamukçu, Z; Turan, A, 2002) |
| " bolus infusion rate of propofol does not influence drug-induced local pain on injection, at least not within the infusion rate interval studied." | 5.10 | Propofol infusion rate does not affect local pain on injection. ( Akeson, J; Grauers, A; Liljeroth, E, 2002) |
| "In a randomised, double-blinded, two-centre trial we evaluated the effect of a microbiological filter (Supor, Pall Life Sciences) on propofol injection pain." | 5.10 | Efficacy of microfiltration in decreasing propofol-induced pain. ( Conn, D; Davies, AF; Dexter, T; Hopwood, B; Vadodaria, B, 2002) |
| "To compare the effects of nitrous oxide with lidocaine on pain on injection caused by propofol in children." | 5.10 | [Prevention of pain on injection with propofol in children: comparison of nitrous oxide with lidocaine]. ( Ecoffey, C; Geslot, D; Lembert, N; Wodey, E, 2002) |
| "The iontophoretic application of lidocaine was compared with intravenous lidocaine to assess the relative efficacy of reducing pain during propofol administration." | 5.10 | Iontophoretically applied lidocaine and the prevention of pain associated with the injection of intravenous propofol: a comparison with intravenous lidocaine. ( Asif, M; Rowbotham, DJ; Sharpe, P; Victoria, A, 2002) |
| " retention of metoclopramide with tourniquet is as good as lidocaine and may be a useful alternative for reducing pain on propofol injection." | 5.09 | Pain on injection of propofol: the mitigating influence of metoclopramide using different techniques. ( Chang, DP; Hwang, MH; Liaw, WJ; Pang, WW, 1999) |
| "We used a randomized, controlled, double-blinded design to study the effect of ondansetron (OND) pretreatment on the pain produced by the IV injection of propofol." | 5.09 | Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study. ( Ambesh, SP; Dubey, PK; Sinha, PK, 1999) |
| "We have compared iontophoretically and locally applied lidocaine for relief of pain on propofol injection." | 5.09 | Iontophoretically applied lidocaine reduces pain on propofol injection. ( Liddle, A; Maslowski, P; Rowbotham, DJ; Sadler, PJ; Thompson, HM, 1999) |
| "To determine the optimal concentration of lidocaine that reduces pain on injection of a propofol-lidocaine mixture." | 5.09 | The optimal effective concentration of lidocaine to reduce pain on injection of propofol. ( Chu, CC; Ho, CM; Lee, TY; Sun, MS; Tsou, MY, 1999) |
| "We examined the effects of injection rate of propofol on injection pain and postinduction hypotension and bradycardia when fentanyl was administrated before propofol." | 5.09 | [Effects of speed of injection on anesthesia induction with propofol and fentanyl]. ( Ichimiya, T; Kamada, Y; Kobayashi, Y; Namiki, A; Seki, S; Tsuchida, A, 1999) |
| "We examined the influence of the bolus injection rate of propofol on the cardiovascular depression and injection pain." | 5.09 | [Effects of the bolus injection rate on anesthesia induction with propofol]. ( Ichimiya, T; Kamada, Y; Kobayashi, Y; Namiki, A; Seki, S; Tsuchida, A, 1999) |
| "The purpose of this study was to compare the effect of premixed 5% dextrose in Ringer's acetate solution and premixed lidocaine with propofpl on the reduction of pain during injection of propofol in adult patients." | 5.09 | [Premixing of 5% dextrose in Ringer's acetate solution with propofol reduces incidence and severity of pain on propofol injection]. ( Kashimoto, S; Kumazawa, T; Nonaka, A; Oguchi, T; Sugawara, T; Tamaki, F, 1999) |
| " Inadequate analgesia was treated with IV propofol, and the epidural was activated for a pain score greater than 6 on a 10-point verbal analog pain scale." | 5.09 | Determination of the effective therapeutic dose of intrathecal sufentanil for extracorporeal shock wave lithotripsy. ( Faerber, GJ; Golembiewski, JA; Green, CR; Lau, WC; Tait, AR, 1999) |
| " The pain which occurs as a response to an intravenous injection of Propofol is one of the main obstacles to its use as an anesthetic." | 5.09 | [Administration of propofol. Addition of lidocaine eases the pain]. ( Fernández, V; Hernández, S; López, S; Santamaría, R, 1999) |
| "To elucidate the mechanism of propofol-induced pain on injection, we performed several studies using nafamostat mesilate, a kallikrein inhibitor, or lidocaine." | 5.09 | A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate. ( Iwama, H; Nakane, M, 1999) |
| "We performed a randomised, double-blind, prospective trial to discover whether intravenous ketorolac 10 mg made up to 2 ml with saline, with or without venous occlusion for 2 min, reduces the pain on injection of propofol." | 5.09 | Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol. ( Barkshire, KF; Dexter, T; Yull, DN, 2000) |
| "A prospective, randomized, double-blind study was conducted to determine whether cooled intravenous propofol reduces the incidence of pain on induction of anaesthesia in children." | 5.09 | Propofol and pain on induction: the effect of injectate temperature in children. ( Burden, J; Lewis, I; Pickford, A, 2000) |
| "Propofol injection associated with a high incidence of pain is well known." | 5.09 | Propofol-sodium thiopental admixture reduces pain on injection. ( Cheng, KS; Kau, YC; Wu, RS, 2000) |
| "The purpose of this study was to compare the younger and older patients in the incidence and the severity of the pain during injection of propofol." | 5.09 | [Effect of pre-mixed lidocaine with propofol on propofol injection pain in elderly patients]. ( Kumazawa, T; Nonaka, A; Suzuki, M; Suzuki, S; Tamaki, F, 2000) |
| "To determine whether epidural lidocaine reduces the severity of propofol injection pain compared with iv lidocaine." | 5.09 | Epidural anesthesia with lidocaine reduces propofol injection pain. ( Inoue, T; Ogawa, R; Ogura, A; Wajima, Z; Yoshikawa, T, 2001) |
| "Pain intensity at the site of propofol injection was found not to be influenced by simultaneous iv infusion of carrier fluid." | 5.09 | Pain on injection of propofol with or without infusion of carrier fluid. ( Akeson, J; Grauers, A; Liljeroth, E, 2001) |
| "In a test of two formulations of propofol for induction, patients experienced less pain with the formulation in Intralipid (Propofol-Lipuro 1%) than with Diprivan 1%." | 5.09 | Propofol in an emulsion of long- and medium-chain triglycerides: the effect on pain. ( Doenicke, AW; O'Connor, MF; Rau, J; Roizen, MF; Strohschneider, U, 2001) |
| "Propofol is frequently associated with pain on injection." | 5.09 | Role of tramadol in reducing pain on propofol injection. ( Cheong, KF; Wong, WH, 2001) |
| "In a randomised, controlled, double-blinded trial to study the effect of ondansetron pretreatment on the pain produced after intravenous injection of rocuronium and propofol in comparison with lidocaine, 60 patients were randomly assigned to one of three groups." | 5.09 | Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. ( Chen, FG; Ng, HP; Reddy, MS, 2001) |
| "We examined the analgesic effects of orally administered clonidine on pain induced by injection of propofol (Diprivan; 2,6-diisopropyl phenol)." | 5.09 | Orally administered clonidine significantly reduces pain during injection of propofol. ( Inoue, T; Ogawa, R; Ogura, A; Wajima, Z; Yoshikawa, T, 2001) |
| "This prospective, randomised, double-blind study was designed to compare the incidence and intensity of pain on injection of propofol formulated in a mixture of medium- and long-chain triglycerides, Propofol-MCT/LCT 1% (Propofol-Lipuro, B." | 5.09 | [Injection pain from propofol-MCT-LCT in children. A comparison with propofol-LCT]. ( Beerhalter, U; Erdkönig, R; Larsen, B; Larsen, R, 2001) |
| "To investigate the effect of simultaneous bolus injection of 2% lidocaine 2 ml on preventing the pain on propofol injection, 80 patients were randomly assigned to one of four study groups; Group I received simultaneous bolus injection of 2% lidocaine 2 ml with infusion of propofol; Group II received bolus injection of saline 2 ml, 10 s before the start of infusion of propofol-lidocaine mixture; Groups III and IV received bolus injections of lidocaine and saline, separately 10 s before starting propofol infusion." | 5.09 | [Efficacy of simultaneous bolus injection of lidocaine with propofol on pain caused by propofol injection]. ( Adachi, H; Harada, T; Hirosawa, J; Inagaki, Y; Ishibe, Y; Otsuki, A; Tsubokura, H, 2001) |
| "Pain on injection is a major disadvantage of propofol, experienced by the vast majority of patients." | 5.09 | [Less pain on injection by a new formulation of propofol? A comparison with propofol LCT]. ( Beerhalter, U; Biedler, A; Brandt, A; Brün, K; Doege, F; Erdkönig, R; Larsen, B; Larsen, R, 2001) |
| "The aim of this study was to investigate pain perception during thiopentone or propofol infusions for sedation." | 5.08 | Sedation with intravenous infusions of propofol or thiopentone. Effects on pain perception. ( Kolletzki, M; Wilder-Smith, CH; Wilder-Smith, OH, 1995) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 5.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| "Pain is a well known complication of propofol injection." | 5.08 | Modulating effects of lignocaine on propofol. ( Khoo, ST; Tham, CS, 1995) |
| "This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia." | 5.08 | Thiopentone pretreatment for propofol injection pain in ambulatory patients. ( Haugen, RD; Merrick, PM; Vaghadia, H; Waters, T, 1995) |
| "We undertook a randomized, placebo-controlled, double-blind study to compare the use of alfentanil 1 mg and lidocaine 40 mg for the reduction of pain during injection of propofol." | 5.08 | Prevention of pain on injection of propofol: a comparison of lidocaine with alfentanil. ( Gajraj, NM; Nathanson, MH; Russell, JA, 1996) |
| "We hypothesized that the concentration of propofol in the aqueous phase may be the most important variable responsible for the pain experienced during injection of the drug." | 5.08 | Reducing pain during propofol injection: the role of the solvent. ( Babl, J; Doenicke, AW; Kellermann, W; Rau, J; Roizen, MF, 1996) |
| "9% saline (1 ml) on a double-blind basis, as pretreatment to reduce pain on injection of propofol." | 5.08 | Modification of pain on injection of propofol. A comparison of pethidine and lignocaine. ( Flynn, C; Lohan, D; Lyons, B; McCarroll, M, 1996) |
| "Propofol has been shown to cause pain on injection." | 5.08 | The effect of temperature upon pain during injection of propofol. ( Davidson, JA; Fletcher, GC; Gillespie, JA, 1996) |
| "We have investigated if alfentanil acts via peripheral opioid receptors to relieve the pain which occurs on injection of propofol." | 5.08 | Alfentanil-mediated analgesia during propofol injection: no evidence for a peripheral action. ( Girling, KJ; Hobbs, GJ; Wrench, IJ, 1996) |
| "A randomised, controlled, single-blind study was performed on 100 patients to investigate a new method of reducing pain on propofol injection." | 5.08 | Injection pain with propofol. Reduction with aspiration of blood. ( Jameson, P; McDonald, DS, 1996) |
| "A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol." | 5.08 | The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996) |
| "To define the optimal dose of lidocaine to be added to propofol to reduce the incidence of pain during its injection." | 5.08 | Preventing pain during injection of propofol: the optimal dose of lidocaine. ( Gajraj, NM; Nathanson, MH, 1996) |
| "To compare the local efficacy of lidocaine and fentanyl in reducing propofol injection pain (PIP), we conducted a prospective randomized double-blind study in 75 ASA I and II adult patients." | 5.08 | Reduction of propofol pain--fentanyl vs lidocaine. ( Alyafi, WA; Rangasami, J, 1996) |
| "We investigated hemodynamic changes, induction time and the incidence of pain after rapid induction of anesthesia with propofol (Group P) in comparison with those after induction with thiopental (Group B)." | 5.08 | [Rapid induction of anesthesia with propofol--comparison with thiopental]. ( Hanaoka, K; Nishiyama, T, 1996) |
| ") lidocaine and topical nitroglycerin ointment in preventing pain during propofol injection." | 5.08 | Effects of topical nitroglycerin and intravenous lidocaine on propofol-induced pain on injection. ( Beven, M; Carpenter, T; Laseter, JT; Mascha, E; Maurer, WG; O'Hara, JR; Sprung, J, 1997) |
| " A high incidence of pain with drug injection was noted among patients receiving propofol (80%)." | 5.08 | Propofol patient-controlled sedation during hip or knee arthroplasty in elderly patients. ( Ganapathy, S; Gelb, AW; Herrick, IA; Kirkby, J, 1997) |
| "kg-1 propofolis not effective in the treatment of postoperative vomiting in children after adenotonsillectomy when a standardized anaesthetic with thiopentone, halothane, nitrous oxide, and 1." | 5.08 | Subhypnotic propofol does not treat postoperative vomiting in children after adenotonsillectomy. ( Carr, AS; Lerman, J; McAuliffe, G; Sikich, N; Smith, HS; Zestos, MM, 1997) |
| "The purpose of this study was to confirm the effect of premixed lidocaine for the reduction of pain during injection of propofol in adult patients." | 5.08 | [Premixing lidocaine reduces the incidence and severity of pain on injection of propofol]. ( Akazawa, S; Fukuda, H; Inoue, S; Kasuda, H; Kawakami, T; Konishi, R; Mitsuhata, H; Saitoh, J; Saitoh, K; Shimizu, R; Suzuki, H, 1997) |
| "Pain is a well known complication of propofol injection." | 5.08 | [Effect of lidocaine administration mode on decreasing injection pain caused by propofol]. ( Bornscheuer, A; Goldmann, R; Kirchner, E, 1997) |
| "Propofol has the disadvantage of pain on injection." | 5.08 | Effect of lignocaine and pH on propofol-induced pain. ( Englesson, S; Eriksson, M; Hartvig, P; Niklasson, F, 1997) |
| " set (DLIS) decreases the incidence of propofol injection pain compared with single lumen i." | 5.08 | Reduction of propofol injection pain with a double lumen i.v. set. ( Angst, MS; Brock-Utne, JG; Mackey, SC; Tataru, CD; Zupfer, GH, 1997) |
| "We determined whether pretreatment with topical 60% lidocaine tape reduced the incidence of pain on injection of propofol compared with mixing intravenous lidocaine with propofol." | 5.08 | Pretreatment with topical 60% lidocaine tape reduces pain on injection of propofol. ( Hosoda, R; Kimura, T; Komatsu, T; Komura, Y; Nishiwaki, K; Shimada, Y; Yokota, S, 1997) |
| "Pain on injection is the most commonly reported adverse event after propofol injection." | 5.08 | Pharmacokinetics and pharmacodynamics of propofol in a new solvent. ( Babl, J; Doenicke, AW; Klotz, U; Kugler, J; O'Connor, M; Rau, J; Roizen, MF, 1997) |
| " pretreatment with fentanyl, morphine, meperidine, or lidocaine in reducing propofol injection pain." | 5.08 | The analgesic effect of fentanyl, morphine, meperidine, and lidocaine in the peripheral veins: a comparative study. ( Huang, S; Hwang, MH; Mok, MS; Pang, WW, 1998) |
| "Propofol is frequently associated with pain on injection." | 5.08 | Pain on injection of propofol. A comparison of cold propofol with propofol premixed with lignocaine. ( Koay, CK; Parmar, AK, 1998) |
| "Intra- and postoperative wake-up tests were performed together with somatosensory cortical evoked potentials (SCEPs) monitoring in 40 patients randomized to either midazolam (M) or propofol (P) infusions for scoliosis surgery." | 5.08 | Midazolam-flumazenil versus propofol anaesthesia for scoliosis surgery with wake-up tests. ( Hesselbjerg, L; Koscielniak-Nielsen, ZJ; Stens-Pedersen, HL, 1998) |
| ") retention of fentanyl and lidocaine in reducing the pain on i." | 5.08 | Comparison of intravenous retention of fentanyl and lidocaine on local analgesia in propofol injection pain. ( Chang, DP; Chung, YT; Hong, MH; Huang, S; Lin, SS; Pang, WW, 1997) |
| "9% saline (1 ml) on propofol injection pain." | 5.08 | The effect of ketamine pretreatment on propofol injection pain in 100 women. ( Kua, SW; Onsiong, MK; Tan, CH, 1998) |
| "Pain on injection is one of the well-known side effects of propofol." | 5.08 | [Pain-free injection of propofol]. ( Ichimiya, T; Kamada, Y; Kobayashi, Y; Kumagai, A; Namiki, A; Seki, S; Tsuchida, H, 1998) |
| "We evaluated the efficacy of the 60% lidocaine tape in alleviating pain associated with intravenous propofol administration in 71 gynecological patients." | 5.08 | [Sixty percent lidocaine tape alleviates pain on injection of propofol after diminishing venipuncture pain]. ( Akatsuka, M; Doi, Y; Inamori, K; Kunimasa, K; Minami, T; Mori, H; Ohnaka, M; Ohtsuka, M; Uda, R, 1998) |
| "We compared the effect of fentanyl and lidocaine on pain during injection of propofol." | 5.08 | [Reduction of pain on injection of propofol: a comparison of fentanyl with lidocaine]. ( Aketa, K; Ichimiya, T; Kobayashi, Y; Naganuma, R; Namiki, A; Seki, S, 1998) |
| "The purpose of the present study is to compare the injection pain of propofol with that of benzodiazepines when used for intravenous sedation." | 5.08 | Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. ( Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T, 1998) |
| "We have examined the preventative effect of nafamostat mesilate, a kallikrein inhibitor, on pain on injection with propofol in a randomized, double-blind study." | 5.08 | Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol. ( Iwama, H; Kaneko, T; Kato, M; Nakane, M; Ohmori, S; Okuaki, A; Watanabe, K, 1998) |
| "Lignocaine has been shown to reduce the incidence of pain on injection of propofol." | 5.07 | Propofol injection pain: comparing the addition of lignocaine or metoclopramide. ( Mecklem, DW, 1994) |
| "A controlled, double-blind study was performed to compare the prior administration of intravenous saline 4 ml (n = 36), lignocaine 20 mg (n = 36) or thiopentone 100 mg (n = 43) on the pain produced by intravenous injection of propofol." | 5.07 | Pain during injection of propofol. The effect of prior administration of thiopentone. ( Lee, TW; Loewenthal, AE; Strachan, JA; Todd, BD, 1994) |
| "A controlled randomized double-blinded clinical study was undertaken to evaluate and compare the efficacy of three methods of preventing pain during injection of propofol on induction of anesthesia." | 5.07 | Pain on injection of propofol. ( Chen, GT; Chen, TY; Hwang, MH; Lin, JC; Lin, SS, 1994) |
| "We have compared two groups (n = 22) of unpremedicated patients to determine if the pain caused by injection of propofol could be modified by alfentanil." | 5.07 | Pretreatment with alfentanil reduces pain caused by propofol. ( Bowen, DJ; Fletcher, JE; Seavell, CR, 1994) |
| "The effect of fentanyl, administered immediately before propofol, when pain is experienced at the site of propofol injection was studied in 28 children undergoing elective surgery." | 5.07 | [Fentanyl prevents the pain at the site of propofol injection]. ( Chessa, D; Cossu, F; Serra, G, 1992) |
| "We have conducted a randomized, double-blind study in 255 ASA I and II patients to compare the efficacy of lignocaine and metoclopramide in minimizing the pain of injection of i." | 5.07 | Pain on injection of propofol: comparison of lignocaine with metoclopramide. ( Fee, JP; Ganta, R, 1992) |
| " To limit pain during injection, alfentanil (5 micrograms/kg) was administered before the propofol." | 5.07 | Propofol requirements for induction of anesthesia in children of different age groups. ( Axt, P; Byttebier, GO; Erdmann, W; Manschot, HJ; Meursing, AE, 1992) |
| "kg-1 on reducing injection pain caused by propofol was compared with lignocaine 10 mg mixed with propofol (Lign)." | 5.07 | Injection pain, cardiovascular changes and recovery following induction of anaesthesia with propofol in combination with alfentanil or lignocaine in children. ( Hiller, A; Saarnivaara, L, 1992) |
| "In a single-blind study of 100 children aged 1 to 10 years, the minimum effective dose of lignocaine required to prevent injection pain due to propofol was 0." | 5.07 | The minimum effective dose of lignocaine to prevent injection pain due to propofol in children. ( Cameron, E; Crofts, S; Johnston, G; Morton, NS, 1992) |
| "Propofol has a high incidence of pain with injection, particularly into small veins." | 5.07 | Lidocaine for the prevention of pain due to injection of propofol. ( Davis, FM; King, SY; Murchison, DJ; Pryor, PJ; Wells, JE, 1992) |
| "We evaluated the efficacy of intravenous lidocaine, with and without a tourniquet, to decrease the intensity of pain during intravenous propofol injection in 82 patients undergoing general anesthesia." | 5.07 | Tourniquet at 50 mm Hg followed by intravenous lidocaine diminishes hand pain associated with propofol injection. ( Holak, EJ; Mangar, D, 1992) |
| "Three modes of administration of alfentanil were assessed in order to reduce pain on injection with propofol." | 5.07 | [The effect of alfentanil on pain caused by the injection of propofol during anesthesia induction in children]. ( Dru, M; Journois, D; Lory, C; Playe, E, 1991) |
| "A single-blind, randomised, controlled study was undertaken to compare the efficacy of three methods of preventing pain during injection of propofol on induction of anaesthesia." | 5.07 | Effect of prior administration of cold saline on pain during propofol injection. A comparison with cold propofol and propofol with lignocaine. ( Barker, P; Langton, JA; Murphy, P; Rowbotham, DJ, 1991) |
| "The emulsion formulation of propofol (Diprivan) evokes pain on i." | 5.07 | Pain on injection of propofol: effects of concentration and diluent. ( Arndt, JO; Klement, W, 1991) |
| "Pain on injection of propofol was assessed in a controlled, randomised study of 273 patients." | 5.07 | Modification of pain on injection of propofol--a comparison between lignocaine and procaine. ( A'Hern, RP; Edwards, J; Moriarty, J; Nicol, ME; Robbie, DS, 1991) |
| "The purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol." | 5.07 | Optimal dose of lignocaine for preventing pain on injection of propofol. ( Gehan, G; Karoubi, P; Leroy, A; Pourriat, JL; Quinet, F; Rathat, C, 1991) |
| "A controlled randomised double-blind design was used to study the effect of lignocaine on the pain produced by intravenous injection of propofol." | 5.06 | Pain on injection of propofol. Methods of alleviation. ( Chadwick, S; Harper, NJ; Johnson, RA; Vohra, A, 1990) |
| "A double-blind, randomised clinical study was undertaken to compare the effect of temperature on the incidence and severity of the pain experienced on injection of propofol." | 5.06 | Pain on injection of propofol: the effect of injectate temperature. ( Hunter, S; McCrirrick, A, 1990) |
| "The efficacy of lignocaine (1%) mixed with propofol in reducing pain on injection with propofol was studied in 40 children undergoing elective surgery in a double-blind, randomized comparison with glucose (5%)." | 5.06 | Propofol as an induction agent in children: pain on injection and pharmacokinetics. ( Iisalo, E; Kanto, J; Rosenberg, P; Valtonen, M, 1989) |
| "Eight modes of administration of propofol were assessed in order to minimise the pain of injection." | 5.06 | Propofol: clinical strategies for preventing the pain of injection. ( Norman, J; Saunders, DA; Scott, RP, 1988) |
| "Propofol injection pain is a very common problem during the induction of general anesthesia." | 5.05 | Dexmedetomidine for prevention of propofol injection pain upon induction of anesthesia: a meta-analysis. ( Ji, L; Lan, Y; Sun, W; Wu, Q; Xia, C; Xu, X; Yang, S; Yu, G, 2020) |
| "17), and the reduction in apnea or hyoxemia (OR=0." | 4.95 | The Comparison of Etomidate and Propofol Anesthesia in Patients Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis. ( Xiao, X; Ye, L; Zhu, L, 2017) |
| " All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled." | 4.95 | Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials. ( Fu, YZ; Lang, BC; Yang, CS; Zhang, LL; Zhang, WS, 2017) |
| "5-hydroxytryptamine3 (5-HT3) receptor antagonists have been commonly used to reduce propofol injection pain." | 4.93 | 5-HT3 Receptor Antagonists for Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials. ( Sun, L; Wang, T; Wang, W; Wu, LX; Zhang, CB; Zhou, L, 2016) |
| "The objective of this review was to determine the efficacy and adverse effects of lidocaine in preventing high-intensity pain on propofol injection." | 4.93 | Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults. ( Dej-Arkom, S; Euasobhon, P; Lumbiganon, P; Muangman, S; Pattanittum, P; Siriussawakul, A; Sriraj, W, 2016) |
| "To evaluate the anesthesia effect of etomidate and propofol on painless abortion surgery." | 4.93 | [Meta analysis for the anesthesia effect and adverse reactions of etomidate and propofol on the painless abortion surgery]. ( Li, W; Long, L; Wang, L; Xu, R, 2016) |
| "Pain on injection (angialgia) is a common adverse effect of anesthetic medications, especially propofol and methohexital, which are both used for electroconvulsive therapy (ECT)." | 4.90 | Anesthetic-induced pain on injection in electroconvulsive therapy: review of the literature and suggestions for prevention. ( Rasmussen, KG; Ritter, MJ, 2014) |
| "We conducted a comprehensive meta-analysis of studies to appraise the efficacy and safety of flurbiprofen axetil for controlling pain induced by propofol injection." | 4.90 | Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis. ( Bao, H; Luo, Z; Shi, H; Wang, H; Xu, L; Yu, Y; Zhang, L; Zhang, X; Zhang, Y; Zhao, Y; Zhu, J, 2014) |
| "To examine whether, according to the conclusions of a 2000 systematic review with meta-analysis on interventions to prevent pain from propofol injection that provided a research agenda to guide further research on the topic, subsequently published trials were more often optimally blinded, reported on children, and used the most efficacious intervention as comparator; and to check whether the number of new trials published each year had decreased and whether the designs of trials that cited the review differed from those that did not." | 4.90 | Ability of a meta-analysis to prevent redundant research: systematic review of studies on pain from propofol injection. ( Elia, N; Habre, C; Pöpping, DM; Tramèr, MR, 2014) |
| ", hypoxia, hypotension, arrhythmia, and apnea) and sedation profiles were assessed." | 4.89 | The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. ( Chen, C; Chen, J; Deng, D; Liu, J; Long, A; Tang, D; Wang, D; Wang, L; Xu, Y; Zhu, Z, 2013) |
| "To systematically determine the most efficacious approach for preventing pain on injection of propofol." | 4.87 | Prevention of pain on injection of propofol: systematic review and meta-analysis. ( Apfel, CC; George, E; Hornuss, C; Jalota, L; Kalira, V; Pace, NL; Radke, O; Shi, YY, 2011) |
| "Pain on injection of propofol is a common problem, the cause of which remains unknown." | 4.80 | Pain on injection of propofol. ( Onsiong, MK; Tan, CH, 1998) |
| "The best intervention to prevent pain on injection with propofol is unknown." | 4.80 | Prevention of pain on injection with propofol: a quantitative systematic review. ( Picard, P; Tramèr, MR, 2000) |
| "At low remifentanil doses, we observed partial activation in brain areas processing sensory-discriminative and emotional-affective aspects of pain." | 4.31 | Effects of remifentanil on brain responses to noxious stimuli during deep propofol sedation. ( Blanco-Hinojo, L; Bonhomme, V; Deus, J; Fernández-Candil, J; Gallart, L; Gambús, PL; Martínez-Vilavella, G; Pacreu, S; Pérez-Sola, V; Pujol, J, 2023) |
| " Within 48 h of admission, we compared total amounts of sedation/pain medications (morphine milligram equivalents (MME), propofol, dexmedetomidine, benzodiazepines) with total resuscitation volumes and frequency of hypotensive episodes." | 4.31 | The risks of sedation and pain control during burn resuscitation: Increased opioids lead to over-resuscitation and hypotension. ( Anderson, J; Mandell, SP; McClellan, JM; O'Neal, J; Sheckter, C; Stanton, E, 2023) |
| "Propofol, a general anesthetic administered intravenously, may cause pain at the injection site." | 4.12 | Propofol Causes Sustained Ca2+ Elevation in Endothelial Cells by Stimulating Ryanodine Receptor and Suppressing Plasmalemmal Ca2+ Pump. ( Chan, P; Chen, CY; Chuang, CM; Leung, YM; Shiao, LR; Wong, KL; Wu, CH; Yen, PS, 2022) |
| " There was a significant decrease in propofol and fentanyl utilization from 24 hours pretracheostomy to 24 hours posttracheostomy in both dose and number of patients receiving these continuous intravenous medications." | 4.12 | Tracheostomy decreases continuous analgesia and sedation requirements. ( Droege, CA; Elson, NC; Goodman, MD; Hayes, HV; Nomellini, V; Pritts, TA; Salvator, A; Singer, KE; Wallen, TE, 2022) |
| "For endotracheal suctioning, NFR, BPS, CPOT and RASS showed predictive performances significantly better than chance, but none of them performed significantly better than the sufentanil dose rate." | 4.12 | Investigation of Behavioural Pain Scale, Critical Care Pain Observation Tool, nociceptive flexion reflex and pupillary dilatation reflex as predictors of behavioural reactions to nociceptive procedures in critically ill patients unable to self-report pain ( Bublitz, VK; Jurth, C; Lezius, F; Lichtner, G; Schaaf, L; von Dincklage, F; Zimmermann, V, 2022) |
| "To discover the effect of propofol intravenous anesthesia along with press-needle therapy on analgesic effect during painless abortion." | 4.12 | Effect of Propofol Intravenous Anesthesia Combined with Press-Needle Therapy on Analgesic Effect during Painless Abortion. ( Chen, C; Fan, B; He, X; Liu, J; Wang, H; Wu, S; Zhu, X, 2022) |
| "In patients pretreated with lidocaine, no pain 56 (87." | 4.02 | Lidocaine for Reduction of Pain Induced by Propofol in a Tertiary Care Hospital: A Descriptive Cross-sectional Study. ( Bahadur Chand, M; Ghimire, B, 2021) |
| " This case report describes the successful use of propofol, an ultra-fast-acting anaesthetic agent commonly used for anaesthesia induction and maintenance to manage refractory agitated delirium in an acute inpatient palliative medicine setting." | 3.96 | Propofol for palliative sedation. ( Michael, NG; Sulistio, M; Wojnar, R, 2020) |
| "BACKGROUND This study aimed to investigate the molecular mechanisms associated with the effects of propofol in a rat model of pain due to inflammation following subcutaneous injection with complete Freund's adjuvant (CFA)." | 3.91 | The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund's Adjuvant. ( Liu, H; Tan, S; Wang, Y; Zhu, S, 2019) |
| " Fentanyl (77%) and hydromorphone (48%) were the most common intravenous opioids used to manage pain." | 3.91 | Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation. ( Abrams, D; Agerstrand, C; Brodie, D; Dzierba, AL; Madahar, P; Muir, J, 2019) |
| "Compared to propofol and general anesthesia, midazolam/fentanyl sedation was associated with an increased periprocedural perception of pain and lower local tumor progression-free survival." | 3.91 | Propofol Compared to Midazolam Sedation and to General Anesthesia for Percutaneous Microwave Ablation in Patients with Hepatic Malignancies: A Single-Center Comparative Analysis of Three Historical Cohorts. ( de Jong, MC; de Vries, JJJ; Geboers, B; Gerçek, CC; Hoedemaker-Boon, CJ; Meijerink, MR; Nieuwenhuizen, S; Puijk, RS; Ruarus, AH; Scheffer, HJ; Thöne-Passchier, DH; van den Tol, PMP; Vroomen, LGPH; Ziedses des Plantes, V, 2019) |
| " The propofol pain was assessed according to the verbal rating scale (VRS)." | 3.88 | The evaluation of the effect of venous diameter measurement by ultrasonography on pain and withdrawal response. ( Hatiboğlu, Y; Yılmaz, S, 2018) |
| "To investigate the efficacy of lornoxicam in the prevention of the pain associated with propofol injection." | 3.85 | Lornoxicam use to reduce the pain associated with propofol injection. ( Aksoy, Y; Başak, N; Kaydu, A; Şahin, ÖF, 2017) |
| "A short review was carried out to see if mixing lidocaine with propofol is a safe and effective method in reducing the commonly reported pain at the injection site." | 3.85 | BET 1: Lidocaine with propofol to reduce pain on injection. ( Baombe, JP; Howard, L, 2017) |
| "Current endeavor was aimed towards studying significance of lipid composition on free propofol concentration in aqueous phase and associated pain on injection." | 3.85 | Effect of Lipid Composition in Propofol Formulations: Decisive Component in Reducing the Free Propofol Content and Improving Pharmacodynamic Profiles. ( Darandale, SS; Shevalkar, GB; Vavia, PR, 2017) |
| "The main objective was to verify whether propofol could allow us to administer care without causing major pain to patients with refractory pain at the end of life." | 3.85 | Sedation by Propofol for Painful Care Procedures at the End of Life: A Pilot Study. PROPOPAL 1. ( Castelli-Prieto, M; Ciais, JF; Jestin, C; Tremellat, F, 2017) |
| " Incisional pain was ranked as most undesirable, followed (in order) by vomiting, gagging on the tracheal tube, nausea, sore throat, propofol injection pain, shivering, intravenous puncture pain, and anxiety." | 3.85 | Is propofol injection pain really important to patients? ( Sun, L; Wang, W; Wu, L; Zhang, C, 2017) |
| " Chitosan oligosaccharide (COS), a kind of natural product with anti-pain and anti-inflammatory activities, may be a potential adjuvant to propofol use." | 3.83 | Chitosan Oligosaccharide Reduces Propofol Requirements and Propofol-Related Side Effects. ( Li, Z; Ma, H; Song, X; Yang, X; Zhang, P, 2016) |
| " Propofol was given to patients reporting pain or discomfort throughout the procedure." | 3.81 | Incidence of and indications for conversion of cervical plexus block to general anesthesia in patients undergoing carotid surgery: a single center experience. ( Davidovic, LB; Koncar, I; Kostic, D; Lucic, M; Sindjelic, RP; Vlajkovic, GP, 2015) |
| "Propofol, a commonly used intravenous anesthetic agent, is known to at times cause pain sensation upon injection in humans." | 3.81 | Propofol-induced pain sensation involves multiple mechanisms in sensory neurons. ( Kashio, M; Nishimoto, R; Tominaga, M, 2015) |
| "Formalin-induced acute inflammatory pain was established by intraplantar injection of 1% formalin without anesthesia or with anesthesia using the clinical anesthetics sevoflurane, propofol, or pentobarbital sodium." | 3.81 | Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex. ( Dai, RP; Li, CQ; Luo, C; Luo, W; Xu, JM; Zhang, YL; Zhou, FH, 2015) |
| " The aims of this observational study were to test whether ANI could early detect hemodynamic reactivity (HemodR) during propofol anesthesia, measure pain in conscious patients after surgery, and determine ANI predictive thresholds." | 3.80 | Variations of the analgesia nociception index during propofol anesthesia for total knee replacement. ( De Jonckheere, J; Delecroix, M; Jeanne, M; Keribedj, A; Logier, R; Tavernier, B, 2014) |
| "Considering the potential pain and dissatisfaction of rigid cystoscopic ureteral stent removal, procedures utilizing moderate sedation with midazolam or general anesthesia using propofol without muscle relaxation should be considered." | 3.80 | Pain and satisfaction during rigid cystoscopic ureteral stent removal: a preliminary study. ( Cho, SW; Choi, H; Kim, JH; Kim, MG; Park, SY; Song, D; Song, YS, 2014) |
| "Patients with higher anxiety scores (state and trait) required greater amounts of propofol to reach light (BIS=85) and moderate (BIS=75) levels of sedation, but only trait anxiety was significantly associated with propofol requirements in reaching a deep level of sedation (BIS=65)." | 3.78 | Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia. ( Chung, WY; Hong, JY; Kil, HK; Kim, GH; Kim, WO; Seo, H, 2012) |
| "Propofol-evoked injection site pain is not observed with fospropofol." | 3.78 | Receptor specificity defines algogenic properties of propofol and fospropofol. ( Annabi, E; Dussor, G; Edelmayer, R; Malan, P; Patwardhan, A; Price, T, 2012) |
| "At 50 min after intravenous injection of propofol at a constant rate of 70 mg/kg/h, plasma propofol concentrations in the internal carotid artery and internal jugular vein reaches equilibrium with a balanced distribution in all the spinal cord regions." | 3.76 | [Effect of noxious stimulation on regional distribution of propofol in canine spinal cord]. ( Chen, Y; Gu, MN; Lin, CS; Xu, JD; Zhou, FZ, 2010) |
| "The purpose of this study was to examine possible peripheral mechanisms for the reduction of propofol injection pain by the addition of ketamine." | 3.75 | Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol. ( Do, SH; Hwang, J; Jeon, YT; Lee, SC; Lim, YJ; Park, HP, 2009) |
| "We conclude that increased bitter taste sensitivity correlates with increased intensity or incidence of propofol injection pain and NRS of venepuncture pain." | 3.74 | Relation between bitter taste sensitivity and incidence or intensity of propofol injection pain. ( Basaranoglu, G; Delatioglu, H; Erden, V; Kiroglu, S; Korkut, Y; Yangin, Z, 2007) |
| " infusion of propofol, or propofol plus ketamine for deep sedation and analgesia was carried out in two patients with severe epidermolysis bullosa (EB) during extensive dressing changes and deep whirlpool baths." | 3.74 | Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa. ( Wu, J, 2007) |
| "In the present study, behavioral and in vivo electrophysiological methods were used to examine the peripheral effects of propofol on tonic ongoing pain-related responses produced by subcutaneous bee venom-induced inflammatory pain state." | 3.73 | Evidence for peripherally antinociceptive action of propofol in rats: behavioral and spinal neuronal responses to subcutaneous bee venom. ( Chen, J; Li, KC; Sun, YY, 2005) |
| "Collectively our data suggest that propofol-evoked vascular pain is mainly initiated by prostanoids." | 3.73 | Characteristics of propofol-evoked vascular pain in anaesthetized rats. ( Ando, R; Watanabe, C, 2005) |
| "Incidence and intensity of pain on intravenous injection of propofol LCT were compared with those of propofol MCT/LCT." | 3.73 | [Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory]. ( Hoka, S; Inamura, M; Isono, M; Kanai, A; Kosaka, Y; Nakano, T; Nomiyama, S; Okamoto, H; Ozawa, A; Ueno, T, 2005) |
| "Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant haemodynamic side effects." | 3.72 | Comparison of colonoscopies performed under sedation with propofol or with midazolam or without sedation. ( Bates, M; Gasparović, S; Opacić, M; Petrovecki, M; Rustemović, N, 2003) |
| "8% used inhalants (particularly isoflurane) for anesthesia, and ketamine, propofol, and butorphanol were the most commonly used injectable agents." | 3.72 | Evaluation of the use of anesthesia and analgesia in reptiles. ( Read, MR, 2004) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 3.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| " It is also a potential option to avoid the pain frequently associated with the injection of propofol." | 3.71 | A switch from propofol to etomidate during an ECT course increases EEG and motor seizure duration. ( Erfurth, A; Michael, N; Ruta, U; Stadtland, C, 2002) |
| "In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry." | 3.71 | [Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain]. ( Dai, TJ; Duan, SM; Yan, M; Zhang, LC; Zheng, YM, 2002) |
| "Pain at the site of propofol injection is a real problem which requires particular attention in children." | 3.69 | [Pain associated with the injection of Diprivan]. ( Banssillon, V, 1994) |
| "Over an eight-month period, a convenience sample of consenting patients at an urban teaching hospital ED who required sedation for painful procedures were enrolled in a descriptive study of therapeutic propofol sedation." | 3.69 | The use of propofol for sedation in the emergency department. ( Mathias, S; Seaberg, DC; Swanson, ER, 1996) |
| "The author studied the use of intravenous Propofol for the relief of pain." | 3.68 | [Changes in the pain produced by the peripheral venous injection of propofol when it is combined with lidocaine or fentanyl]. ( Croston, J; de Henriquez, L; de Jiménez, L; Espinosa, V, 1992) |
| "Pain on injection of three anaesthetic induction agents, thiopentone, methohexitone and propofol (diisopropyl phenol), administered into a vein on the dorsum of the hand or wrist, was studied in 32 premedicated patients undergoing elective surgery." | 3.67 | Pain on i.v. injection of propofol (ICI 35 868) in emulsion formulation. Short communication. ( Hynynen, M; Korttila, K; Tammisto, T, 1985) |
| "Assessment of pain on injection of the emulsified formulation of di-isopropylphenol (propofol, 'Diprivan') was undertaken in 120 unpremedicated patients and comparison made with thiopentone." | 3.67 | Assessment and modification of pain on induction with propofol (Diprivan). ( Lees, NW; McCulloch, MJ, 1985) |
| "Remimazolam tosilate (RT) is a novel short-acting GABA (A) receptor agonist that has a rapid recovery from procedural sedation and can be fully reversed by flumazenil." | 3.30 | Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial. ( Huang, J; Liu, M; Luo, W; Miao, C; Sun, M; Wan, J; Xia, L; Xiong, W; Xu, P; Zhang, J; Zhang, X; Zhang, Z; Zhong, J, 2023) |
| " The occurrence rates of treatment-emergent adverse events (TEAEs) or drug-related TEAEs were not significantly different between the groups (all p > 0." | 3.30 | Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial. ( An, Y; Chen, C; Guan, X; Kang, Y; Lin, Q; Liu, F; Liu, N; Liu, S; Liu, X; Liu, Y; Lyu, J; Nie, Y; Pan, A; Peng, Z; Sun, R; Wang, H; Wang, X; Wen, J; Wu, J; Wu, K; Yan, J; Yao, L; Yu, J; Yu, X; Zeng, J; Zhan, L; Zhang, L; Zhu, D, 2023) |
| "The incidences of respiratory depression episodes and involuntary movement were less in the group M than those in the group N (0/40 vs." | 3.30 | Effects of intravenous administration of magnesium sulfate in propofol-based sedation for ERCP in elderly patients: a randomized, double-blind, placebo-controlled study. ( Chen, J; Chen, Y; Li, XL; Liu, CH; Qian, K; Wang, JQ, 2023) |
| "Haemodynamic events and respiratory depression in the RT group were less frequent than those in the propofol group ((6/39 vs." | 3.11 | Remimazolam tosilate compared with propofol for gastrointestinal endoscopy in elderly patients: a prospective, randomized and controlled study. ( Guo, J; Han, S; Qian, Y; Shi, Q; Xu, J; Zhang, X, 2022) |
| "Remimazolam is an ultrashort-acting benzodiazepine that is potentially a practical option for procedural sedation in colonoscopy." | 3.11 | Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial. ( Chen, L; Fu, B; Guan, J; Liu, L; Yao, Y; Zheng, X, 2022) |
| "Fentanyl was the opioid used in the OCA group." | 3.11 | A comparison of opioid-containing anesthesia versus opioid-free anesthesia using the Cortínez-Sepúlveda model on differential cytokine responses in obese patients undergoing gastric bypass surgery: a randomized controlled trial. ( Campos-Pérez, W; Cuevas, JHM; González-Landeros, D; Martínez-López, E; Pérez-Robles, M; Pérez-Vargas, L; Ramírez-Plascencia, L; Rivera-Valdés, JJ; Sánchez-Muñoz, P, 2022) |
| "Remimazolam is a novel ultra-short-acting benzodiazepine." | 3.11 | Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy. ( Chang, H; Liao, Q; Qing, W; Tong, J; Yu, R; Zhang, F, 2022) |
| "The combination of ketamine-dexmedetomidine for procedural sedation during ERCP is a safe alternative to ketamine-propofol with a better respiratory profile." | 3.11 | Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial. ( Ahuja, V; Aravindan, A; Datta, PK; Ganesh, V; Iyer, KV; Khanna, P; Maitra, S; Sarkar, S; Singh, A, 2022) |
| " Secondary endpoints included time metrics, hemodynamics, consumption of fentanyl, etomidate, propofol, and remimazolam, intraoperative body movement, patient and endoscopist satisfaction scores, supplemental dose of sedative and fentanyl, and incidence and severity of adverse events." | 3.01 | The Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial. ( Ding, B; Liu, L; Liu, X; Sha, Y; Shi, F; Zhang, Y; Zhao, T, 2021) |
| "Agitation commonly complicates polytrauma presentations, and is treated according to the danger it presents to patient and staff." | 3.01 | Management of Pain and Agitation in Trauma. ( Strayer, RJ, 2023) |
| "The meta-analysis currently generates the evidence of combination of propofol with the dosage of 0." | 3.01 | Propofol decreased the etomidate-induced myoclonus in adult patients: a meta-analysis and systematic review. ( Chang, P; Chen, XB; Feng, Y; Zhang, WS; Zhang, YL, 2023) |
| "Propofol is a commonly used sedative, frequently combined with an opioid or low-dose ketamine as an analgesic." | 3.01 | Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review. ( De Vries, LJ; Lameijer, H; Van Roon, EN; Veeger, NJGM, 2023) |
| "Initial management of migraine with i." | 2.94 | Propofol for migraine in the emergency department: A pilot randomised controlled trial. ( Cameron, PA; Khullar, K; Mercier, E; Mitra, B; Moloney, J; Roman, C; Smit, V; Walsh, K; Yip, G, 2020) |
| " The primary outcome was the dosage of propofol used." | 2.87 | Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study. ( Chan, SKC; Chong, CCN; Lai, PBS; Lau, JYW; Leung, WW; Ng, EKW; Teoh, AYB; Tse, YK; Wu, JCY, 2018) |
| " (4) Compared with control group with the same sedative, the duration of mechanical ventilation, extubation time, length of ICU stay were significantly shortened, and the dosage of sedative drugs used was reduced in study group (all P < 0." | 2.82 | [Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit]. ( Dong, C; Feng, F; Li, J; Qi, Y; Song, R; Yang, J; Yang, Z; Zhang, H, 2016) |
| "Propofol was significantly better than midazolam in inducing amnesia of procedural pain (mean difference 11." | 2.80 | Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children--blind randomised trial. ( Albrecht, P; Dziechciarz, P; Sienkiewicz, E; Ziółkowski, J, 2015) |
| " The primary outcome parameter is the dosage of propofol necessary for an adequate level of sedation to tolerate the procedure (OAA/S < 4)." | 2.80 | A randomised controlled trial: can acupuncture reduce drug requirement during analgosedation with propofol and alfentanil for colonoscopy? A study protocol. ( Eberl, S; Fockens, P; Hollmann, MW; Monteiro de Olivera, N; Preckel, B; Streitberger, K, 2015) |
| "The sufentanil-propofol TCI was carried out during dressing changes." | 2.79 | Prediction of effect-site concentration of sufentanil by dose-response target controlled infusion of sufentanil and propofol for analgesic and sedation maintenance in burn dressing changes. ( Cao, D; Chen, L; Lin, X; Wang, M; Xiang, H; Ye, L, 2014) |
| "And propofol was used for rescue." | 2.79 | [Sedative effects of dexmedetomidine in post-operative elder patients on mechanical ventilation]. ( Huang, F; Jin, J; Kong, J; Liu, S; Wang, J; Xu, H; Yang, X, 2014) |
| "The objective was to assess the effect on stress biomarkers of supplemental opioid to a standard propofol dosing protocol for emergency department (ED) procedural sedation (PS)." | 2.78 | Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines. ( Gray, RO; Ho, JD; Miner, JR; Moore, JC; Patel, S; Plummer, D, 2013) |
| " We designed this study to investigate whether epidural anaesthesia with a goal-directed approach, when combined with general anaesthesia, improved haemodynamic stability in elderly patients undergoing major abdominal surgery." | 2.78 | Epidural anaesthesia with goal-directed administration of ropivacaine improves haemodynamic stability when combined with general anaesthesia in elderly patients undergoing major abdominal surgery. ( Xiao, WP; Yun, X; Zhou, QH, 2013) |
| "To avoid it, an endotracheal tube is retained in patients maintained under sedation overnight." | 2.77 | Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery. ( Fukusaki, M; Higashijima, U; Ichinomiya, T; Miura, K; Sumikawa, K; Tanise, T; Terao, Y, 2012) |
| "Pain was severe in four dogs with Drug(PC)." | 2.77 | Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs. ( Brearley, JC; Leece, EA; Michou, JN, 2012) |
| "Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect." | 2.77 | Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012) |
| "The remifentanil infusion rate was maintained constant unless respiratory and/or cardiovascular unwanted events occurred, whereupon the rate was adjusted in 0." | 2.76 | Remifentanil for the insertion and removal of long-term central venous access during monitored anesthesia care. ( Burlacu, CL; McKeating, K; McShane, AJ, 2011) |
| "Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia." | 2.75 | Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010) |
| " Adverse events and pharmacokinetic and pharmacodynamic characteristics were evaluated." | 2.75 | Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia. ( Cho, SH; Choe, SM; Choi, BM; Ghim, JL; Jung, JA; Lee, HM; Noh, GJ; Roh, YJ, 2010) |
| "In this study recovery profile, postoperative pain scores, incidence of adverse effects, and patient and surgeon satisfaction were compared between paravertebral block (PVB) and fast-track general anesthesia (GA) via laryngeal mask airway (LMA) for outpatient IH." | 2.75 | Comparison of paravertebral block versus fast-track general anesthesia via laryngeal mask airway in outpatient inguinal herniorrhaphy. ( Akcaboy, EY; Akcaboy, ZN; Gogus, N, 2010) |
| "Mean propofol dosage was low and post-procedure recovery times were rapid." | 2.73 | An assessment of computer-assisted personalized sedation: a sedation delivery system to administer propofol for gastrointestinal endoscopy. ( Martin, JF; Moerman, A; Pambianco, DJ; Struys, MM; Whitten, CJ, 2008) |
| "Times to early emergence and tracheal extubation were significantly shorter with LFGF SS than TCI (5." | 2.73 | Low fresh gas flow balanced anesthesia versus target controlled intravenous infusion anesthesia in laparoscopic cholecystectomy: a cost-minimization analysis. ( Dobrasinovic, J; Miljkovic, B; Perunovic, R; Petrova, G; Scepanovic, R; Stevanovic, PD; Stojanovic, D, 2008) |
| "Incidence of postoperative nausea and vomiting and anti-emetic requirements were recorded in the postanaesthetic care unit." | 2.72 | Discomfort on injection: a comparison between two formulations of propofol. ( Allford, MA; Mensah, JA, 2006) |
| "Patients receiving propofol reached full recovery sooner (16." | 2.71 | Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists. ( Chadalawada, V; Hansen, JJ; Liangpunsakul, S; Mendel, AM; Overley, CA; Rex, DK; Strahl, E; Symms, MR; Ulmer, BJ, 2003) |
| "Propofol-Lipuro has an oil phase that allows a larger proportion of propofol to be dissolved in it and, thereby, apparently reduces pain." | 2.71 | A comparison of pain on intravenous injection between two preparations of propofol. ( Irwin, MG; Sun, NCH; Wong, AYC, 2005) |
| "Propofol has several advantages over traditional sedating agents that would indicate its use in treatment-refractory situations." | 2.71 | When nothing helps: propofol as sedative and antiemetic in palliative cancer care. ( Fürst, CJ; Lundström, S; Zachrisson, U, 2005) |
| "Propofol was used for intravenous sedation in a group of 19 healthy fit young patients undergoing third molar extractions." | 2.69 | Two methods of administration of propofol for dental sedation. ( Bridgman, J; Parkinson, R; Zacharias, M, 1998) |
| "No patient had a headache or experienced postural hypotension." | 2.67 | Pain on injection of propofol: modification by nitroglycerin. ( Anderson, M; Gauntlett, IS; Wilkinson, D, 1993) |
| "injection pain was studied in 100 adult patients." | 2.66 | Effect of diluting propofol on the incidence of pain on injection and venous sequelae. ( Hutton, P; Robson, N; Stokes, DN, 1989) |
| "Propofol was associated with a more rapid emergence from anaesthesia than thiopentone." | 2.66 | Propofol vs thiopentone as anaesthetic agents for short operative procedures. ( Carlsson, P; Hägerdal, M; Hallén, B; Henriksson, BA; Lundberg, D; Pontén, J, 1987) |
| "Propofol is an agent commonly used for procedural sedation and analgesia (PSA) in the emergency department (ED), but it can cause respiratory depression and hypotension." | 2.52 | Ketamine-Propofol Versus Propofol Alone for Procedural Sedation in the Emergency Department: A Systematic Review and Meta-analysis. ( Iansavitchene, A; McLeod, SL; Yan, JW, 2015) |
| "Commonly used approaches that are effective to minimise pain or discomfort include intravenous sedoanalgesia, inhalational agents and periprostatic infiltration of local anaesthetic." | 2.50 | Current methods of analgesia for transrectal ultrasonography (TRUS)-guided prostate biopsy -- a systematic review. ( Lee, C; Woo, HH, 2014) |
| "Propofol is a common hypnotic agent in anaesthesiology and intensive care medicine and for procedural sedation as well." | 2.49 | [Propofol up2date]. ( Bushuven, S; Heise, D, 2013) |
| " It also reviews the comparative pharmacokinetics, adverse effects, and dosing of ketamine, propofol, and ketofol as agents for procedural sedation and analgesia." | 2.48 | Ketamine, propofol, and ketofol use for pediatric sedation. ( Alletag, MJ; Auerbach, MA; Baum, CR, 2012) |
| "Tramadol seems to be a potential useful analgesic for term neonates and infants, but has limited indications in (extreme) preterm neonates." | 2.44 | Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists. ( Allegaert, K; de Hoon, J; Naulaers, G; Van De Velde, M, 2008) |
| "Propofol has found increasing popularity with anaesthetists for sedation in the operating theatre." | 2.43 | A review of the use of propofol for procedural sedation in the emergency department. ( Symington, L; Thakore, S, 2006) |
| " Factors influencing dosage include age, ASA class, patient's height and procedure duration." | 2.42 | The dawning of a new sedative: propofol in gastrointestinal endoscopy. ( Heuss, LT; Inauen, W, 2004) |
| "Societal fears of opioid addiction and lack of advocacy are also causal factors in the under-treatment of pediatric pain." | 2.41 | Pain management in the critically ill child. ( Nichols, DG; Yaster, M, 2001) |
| "Propofol is a short-acting intravenous anesthetic commonly utilised in the intensive care unit (ICU) for sedation of mechanically ventilated patients." | 2.40 | Propofol for sedation in the intensive care unit: essentials for the clinician. ( Marinella, MA, 1997) |
| "Propofol is a popular drug for the induction of anaesthesia and sedation in the intensive care." | 2.40 | Prolonged cutaneous sequelae after intra-arterial injection of propofol. ( Ang, BL, 1998) |
| " However, a schedule for age-stratified propofol induction and maintenance dosage for PSA was not available and could be helpful to many anesthesiologists as a reference." | 1.91 | Age-Stratified Propofol Dosage for Pediatric Procedural Sedation and Analgesia. ( Hendriks, MP; van Dijk, H; van Eck-Smaling, MM; van Loon, K; van Wolfswinkel, L, 2023) |
| " Demographic and clinical data, including age, length of the procedure, recovery time, medication doses, and adverse events, were collected." | 1.91 | Safety and Efficacy of Propofol- and Ketamine-Based Procedural Sedation Regimen in Pediatric Patients During Burn Repetitive Dressing Change: 10 Years Single Center Experience. ( Abu-Sultaneh, S; Abulebda, K; Lutfi, R; Shieh Yu, J; Slaven, JE; Yabrodi, M, 2023) |
| "Data saturation was reached after 16 patient interviews." | 1.91 | Patient and staff perceptions of short procedural sedation with propofol for joint and fracture reductions in the Emergency Department: A qualitative study. ( Cooper, JG; Kane, LMY; Pituc, DM; Smith, S, 2023) |
| "Local anesthesia for open inguinal hernia repair is recommended by guidelines but is rarely used in clinical practice in several countries." | 1.72 | Limited use of local anesthesia for open inguinal hernia repair: a qualitative study. ( Laursen, J; Olsen, JHH; Rosenberg, J, 2022) |
| "To determine if adjunctive use of quetiapine reduces sedative dosage requirements among mechanically ventilated adults without delirium." | 1.62 | Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium. ( Cox, CE; Gilstrap, DL; Kram, BL; Kram, SJ; Ohman, KL; Schultheis, JM; Yang, Z, 2021) |
| "Propofol is a sedative and a hypnotic agent used in the induction and maintenance of general anesthesia." | 1.56 | Spastic Cerebral Palsy Pain Improvement With Propofol: A Case Report. ( Guichard, L; Lansaman, T; Martinez, V, 2020) |
| "The aim of this study was to assess the type and frequency of adverse events during the Wada test conducted with propofol as an anaesthetic agent." | 1.51 | Experience of adverse events with cerebral propofol testing in patients with drug resistant epilepsy. ( Bala, A; Marchel, A; Rysz, A; Szantroch, M; Żyłkowski, J, 2019) |
| "Methoxyflurane is an inhalation analgesic used in the emergency department (ED) but also has minimal sedative properties." | 1.51 | Inhaled methoxyflurane for the reduction of acute anterior shoulder dislocation in the emergency department. ( Blom, CJ; Kelliher, JH; McNicholl, B; Umana, E, 2019) |
| "Propofol is a short-acting general anesthetic agent, widely used for induction and maintenance of general anesthesia and rarely employed in palliative care." | 1.51 | Propofol-based palliative sedation in terminally ill children with solid tumors: A case series. ( Angela, M; Annalisa, S; Cefalo, MG; De Pasquale, MD; Del Bufalo, F; Luigi, S; Miele, E; Spinelli, GP, 2019) |
| " Predictors of poorer neurocognitive function were midazolam dosage >3 mg (P<0." | 1.51 | Comparison of the Effects of Midazolam/Fentanyl, Midazolam/Propofol, and Midazolam/Fentanyl/Propofol on Cognitive Function After Gastrointestinal Endoscopy. ( Riordan, S; Seck, V; Thompson, R; Wong, S, 2019) |
| " The results showed that the dosage of sufentanil and propofol decreased significantly in the experimental group (P<0." | 1.48 | Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. ( Xie, M; Xie, S, 2018) |
| "The 124 patients included in the analysis received a median propofol dosage of 3." | 1.46 | Utility of nociceptive flexion reflex threshold and bispectral index to predict movement responses under propofol anaesthesia. ( Baars, JH; Gkaitatzis, S; Hackbarth, M; Jakuscheit, A; Lichtner, G; Neumark, L; Posch, MJ; Schneider, M; von Dincklage, F, 2017) |
| "Propofol sedations were more often associated with the occurrence of apnea's (20% vs." | 1.46 | Propofol versus midazolam for procedural sedation in the emergency department: A study on efficacy and safety. ( Beije, F; Bens, BWJ; Bosch, MGE; Feenstra, R; Lameijer, H; Pol, A; Sikkema, YT; Ter Avest, E, 2017) |
| "Intraoperative awareness and postoperative nausea/vomiting were assessed at follow-up." | 1.46 | Total intravenous anesthesia produces outcomes superior to those with combined intravenous-inhalation anesthesia for laparoscopic gynecological surgery at high altitude. ( Li, H; Peng, Q; Xu, R; Xu, S; Yang, J; Zhang, G; Zhang, Q; Zhou, S, 2017) |
| "Midazolam was the sedative agent used most commonly (45%), and morphine was the most frequently used analgesic agent (36%)." | 1.42 | Emergency department procedural sedation: the London experience. ( Baker, EC; Elkhodair, SM; Freund, Y; Glasebrook, WR; Harris, TR; Pott, JD, 2015) |
| " We recorded adverse events during the endoscopic procedure and additionally retrieved questionnaires investigating subjective parameters 24 h after the endoscopic procedure." | 1.40 | Safety analysis of endoscopist-directed propofol sedation: a prospective, national multicenter study of 24 441 patients in German outpatient practices. ( Beck, S; Friedrich, K; Gotthardt, DN; Heil, FJ; Rex, DK; Scholl, SG; Sieg, A; Stremmel, W, 2014) |
| "45." | 1.40 | Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia. ( Agustí, M; Anglada, T; Gambus, P; Jensen, EW; Jospin, M; López, A; Pineda, P; Ramos, Y; Serra, R; Valencia, JF, 2014) |
| "To strongly improve comfort and quality of life of children with ALL and reduce the risk of TLP+ mainly at diagnosis, we recommend performing the lumbar punctures under analgo-sedation because it is a safe and effective procedure." | 1.40 | Safe lumbar puncture under analgo-sedation in children with acute lymphoblastic leukemia. ( Attinà, G; Chiaretti, A; Coccia, P; Maurizi, P; Riccardi, R; Rizzo, D; Ruggiero, A; Russo, I, 2014) |
| " The dosage of propofol recommended in these guidelines is, however, based on one single study." | 1.39 | [Palliative sedation in a man with oral cancer; the Royal Dutch Medical Association guidelines not always sufficient]. ( Broekhoff, FJ; Dompeling, EC; Smelt, WL; Vos-Westerman, JH; Wulffraat, ET, 2013) |
| "The propofol infusion was closed-loop controlled throughout induction and maintenance of anesthesia, using WAVCNS as feedback." | 1.39 | Robust closed-loop control of induction and maintenance of propofol anesthesia in children. ( Ansermino, JM; Dumont, GA; Khosravi, S; Petersen, CL; Reimer, E; Soltesz, K; Umedaly, A; van Heusden, K; West, N, 2013) |
| "Before intratracheal suctioning, patients had RASS scores of -1." | 1.38 | Assessment of pain in sedated and mechanically ventilated patients: an observational study. ( Hamers, JP; Hantikainen, V; Jakob, SM; Jeitziner, MM; Rohrer, O; Schwendimann, R, 2012) |
| " Blood propofol followed three-compartment pharmacokinetic behavior and derived parameters were not statistically different except for elimination half-life from the CDP formulation and onset, and duration of anesthesia from the FP formulation." | 1.38 | Comparative canine pharmacokinetics-pharmacodynamics of fospropofol disodium injection, propofol emulsion, and cyclodextrin-enabled propofol solution following bolus parenteral administration. ( McIntosh, MP; Rajewski, RA, 2012) |
| " Patient characteristics, American Society of Anesthesiologists (ASA) classification, vital parameters and propofol dosage were registered on specially designed forms." | 1.37 | [Procedural sedation with propofol in non-painful interventions in children]. ( Bruijnen, CJ; Dijkman, KP; Halbertsma, FJ; Mohns, T; van Ooyen, F, 2011) |
| " With the long term vision of an electrochemical sensor for in vivo monitoring and feedback controlled dosing of propofol in blood, different alternatives for the electrochemical quantification of propofol using diverse working electrodes and experimental conditions are presented in this contribution." | 1.37 | Electrochemical quantification of 2,6-diisopropylphenol (propofol). ( Chaum, E; Garay, F; Kivlehan, F; Langmaier, J; Lindner, E, 2011) |
| "Pretreatment with propofol significantly decreased writhing responses induced by visceral pain, suppressed the visceral pain-induced aspartate and glutamate release, and reversed the decreased release of γ-amino butyric acid in the cerebrospinal fluid." | 1.36 | Effects of anesthetic propofol on release of amino acids from the spinal cord during visceral pain. ( Fang, L; Liu, Y; Mu, X; Wang, Y; Wu, A; Wu, J; Yue, Y; Zhang, Y, 2010) |
| " The pharmacodynamic parameters in a sigmoid Emax model were as follows: E0 = 1." | 1.35 | Physicochemical properties, pharmacokinetics, and pharmacodynamics of a reformulated microemulsion propofol in rats. ( Ki, KH; Lee, DH; Lee, EH; Lee, EK; Lee, SH; Noh, GJ; Park, DY, 2008) |
| "New approaches to PCS may address these limitations." | 1.35 | Recent advances in patient-controlled sedation. ( Atkins, JH; Mandel, JE, 2008) |
| "Assisted sedation is a safe and easy method for pain free PVP procedures." | 1.35 | Assisted sedation: a safe and easy method for pain-free percutaneous vertebroplasty. ( Andreula, C; Della Puppa, A; Frass, M, 2008) |
| "Propofol was administered using a standardized protocol, which included an initial dose of 0." | 1.34 | Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study. ( Abu-Laban, RB; Chan, WW; Harrison, DW; Zed, PJ, 2007) |
| "Propofol has a more significant blunting effect on EEG responses to noxious stimulation compared with halothane." | 1.33 | Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation. ( Antognini, JF; Atherley, R; Barter, L; Carstens, E; Dominguez, C; Orth, M, 2005) |
| "We encountered two cases of acute pancreatitis in patients with Cushing's disease following transnasal transsphenoidal hypophysectomy." | 1.33 | Can propofol precipitate pancreatitis in patients with Cushing's syndrome? ( Bhagat, H; Chaturvedi, A; Goswami, R; Pandia, MP; Priya, G; Seth, A, 2005) |
| "The ease of endotracheal intubation has been recently shown to affect the incidence of laryngeal injury." | 1.33 | Tracheal intubation in routine practice with and without muscular relaxation: an observational study. ( Adnet, F; Ait Kaci, F; Baillard, C; Borron, SW; Cupa, M; Fournier, JL; Larmignat, P; Racine, SX; Samama, CM, 2005) |
| "Propofol is an effective agent for use in procedural sedation and analgesia (PSA)." | 1.33 | Propofol by infusion protocol for ED procedural sedation. ( Bigelow, SK; Fay, K; Frank, LR; Hauff, SR; Strote, J, 2006) |
| "Propofol was infused during PVP in eleven cancer patients after obtaining written informed consent." | 1.32 | [Use of propofol for painful procedures in cancer pain management]. ( Nakaho, T; Ohara, T; Takahashi, M; Yamamoto, Y; Yamamuro, M, 2003) |
| "Isoflurane was maintained at 0." | 1.31 | Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats. ( Antognini, JF; Carstens, E; Piercy, M; Wang, XW, 2000) |
| "Propofol was delivered in intermittent boluses to achieve the desired level of anesthesia." | 1.31 | Prospective evaluation of propofol anesthesia in the pediatric intensive care unit for elective oncology procedures in ambulatory and hospitalized children. ( Anderson, BD; Dalton, HJ; Gootenberg, JE; Hauser, GJ; Hertzog, JH; Shad, AT, 2000) |
| "Propofol and midazolam were compared in 40 adult patients in A." | 1.31 | A comparative study of induction and recovery characteristics of propofol and midazolam. ( Dangnan, F; Edomwonyi, NP; Okonofua, BA; Weerasinghe, AS, 2001) |
| "The propofol-evoked increase in [Ca(2+)](i) in the HEK293 cells with the receptor was partially inhibited by capsazepine, a competitive antagonist of capsaicin." | 1.31 | Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells. ( Kohama, K; Nakamura, A; Shirakura, K; Sudo, M; Takagishi, K; Tomioka, A; Tsutsumi, S, 2001) |
| " However, delivery devices such as infusion pumps for drugs like propofol, when coupled with computers to help regulate the infusion rate and monitor the sedative effect, may provide the necessary control for safe administration of propofol and similar drugs by these individuals." | 1.31 | Making patients safe and comfortable for a lifetime of dentistry: frontiers in office-based sedation. ( Yagiela, JA, 2001) |
| "Propofol and fentanyl were administered via computer-assisted continuous infusion to provide stable concentrations and to allow equilibration between plasma-blood and effect-site concentrations." | 1.30 | Reduction by fentanyl of the Cp50 values of propofol and hemodynamic responses to various noxious stimuli. ( Ikeda, K; Kazama, T; Morita, K, 1997) |
| "The results support the hypothesis that hyperalgesia is a property of different anaesthetic agents when administered at sub-hynotic concentrations." | 1.29 | Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. ( Archer, DP; Ewen, A; Roth, SH; Samanani, N, 1995) |
| "Ketamine was not observed to produce any change in either RF size or neuronal response to non-noxious RF stimulation." | 1.29 | Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects. ( Collins, JG; Kishikawa, K; Uchida, H, 1995) |
| " Dose-response curves were monophasic and linear over this range." | 1.28 | Propofol and barbiturate depression of spinal nociceptive neurotransmission. ( Gibbs, LM; Jewett, BA; Kendig, JJ; Tarasiuk, A, 1992) |
| "Propofol was assessed as the main anaesthetic agent for a range of day case surgery that included gynaecological, urogenital, body surface, orthopaedic and dental procedures." | 1.27 | Multicentre study of propofol in day case surgery. ( Blades, JF; Sanderson, JH, 1988) |
| "Propofol 2." | 1.27 | Comparison of induction characteristics of four intravenous anaesthetic agents. ( Dundee, JW; McCollum, JS, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (2.69) | 18.7374 |
| 1990's | 134 (20.03) | 18.2507 |
| 2000's | 245 (36.62) | 29.6817 |
| 2010's | 193 (28.85) | 24.3611 |
| 2020's | 79 (11.81) | 2.80 |
| Authors | Studies |
|---|---|
| Ghimire, B | 1 |
| Bahadur Chand, M | 1 |
| Aminnejad, R | 1 |
| Hormati, A | 1 |
| Shafiee, H | 1 |
| Alemi, F | 1 |
| Hormati, M | 1 |
| Saeidi, M | 1 |
| Ahmadpour, S | 1 |
| Sabouri, SM | 1 |
| Aghaali, M | 1 |
| Liu, X | 3 |
| Guan, X | 2 |
| Jiao, Z | 1 |
| Gong, X | 1 |
| Cao, H | 1 |
| Liu, S | 3 |
| Lan, H | 2 |
| Huang, X | 2 |
| Tan, Y | 1 |
| Xu, B | 1 |
| Lin, C | 1 |
| Ding, B | 1 |
| Shi, F | 1 |
| Zhang, Y | 5 |
| Liu, L | 3 |
| Sha, Y | 1 |
| Zhao, T | 1 |
| Olsen, JHH | 1 |
| Laursen, J | 1 |
| Rosenberg, J | 2 |
| Zhou, L | 2 |
| Wu, R | 1 |
| Cai, C | 1 |
| Qi, Y | 2 |
| Bi, X | 1 |
| Hang, Q | 1 |
| Luo, Z | 2 |
| Tu, H | 1 |
| Zhang, X | 5 |
| Wang, X | 3 |
| Ouyang, W | 1 |
| Wei, X | 1 |
| Zou, X | 3 |
| Zhu, Z | 2 |
| Li, Y | 2 |
| Shangguan, W | 1 |
| Wu, H | 1 |
| Wang, Y | 4 |
| Guo, Q | 1 |
| Chuang, CM | 1 |
| Chen, CY | 1 |
| Yen, PS | 1 |
| Wu, CH | 1 |
| Shiao, LR | 1 |
| Wong, KL | 1 |
| Chan, P | 1 |
| Leung, YM | 1 |
| Li, M | 1 |
| Ke, W | 1 |
| Zhuang, S | 1 |
| Wasinwong, W | 1 |
| Termthong, S | 1 |
| Plansangkate, P | 1 |
| Tanasansuttiporn, J | 1 |
| Kosem, R | 1 |
| Chaofan, S | 1 |
| Chen, XL | 1 |
| Huang, WH | 1 |
| Zheng, YH | 1 |
| Zhang, GC | 1 |
| Wallen, TE | 1 |
| Elson, NC | 1 |
| Singer, KE | 1 |
| Hayes, HV | 1 |
| Salvator, A | 1 |
| Droege, CA | 1 |
| Nomellini, V | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 1 |
| Guo, J | 1 |
| Qian, Y | 1 |
| Han, S | 1 |
| Shi, Q | 1 |
| Xu, J | 1 |
| Yao, Y | 1 |
| Guan, J | 1 |
| Fu, B | 1 |
| Chen, L | 3 |
| Zheng, X | 1 |
| Chen, X | 1 |
| Guo, P | 1 |
| Yang, L | 4 |
| Liu, Z | 2 |
| Yu, D | 1 |
| Cuviello, A | 1 |
| Pasli, M | 1 |
| Bhatia, S | 1 |
| Johnson, LM | 1 |
| Anghelescu, DL | 2 |
| Baker, JN | 1 |
| Fu, D | 1 |
| Wang, D | 2 |
| Li, W | 2 |
| Han, Y | 1 |
| Jia, J | 1 |
| Jurth, C | 1 |
| Zimmermann, V | 1 |
| Schaaf, L | 1 |
| Lezius, F | 1 |
| Bublitz, VK | 1 |
| Lichtner, G | 2 |
| von Dincklage, F | 2 |
| Azarfar, A | 1 |
| Ravanshad, Y | 1 |
| Golsorkhi, M | 1 |
| Zahiri, E | 1 |
| Gharavi Fard, M | 2 |
| Akhondi, M | 1 |
| Ghodsi, A | 1 |
| Ravanshad, S | 1 |
| Li, CY | 1 |
| Chen, ZY | 1 |
| He, HF | 1 |
| Wang, HG | 1 |
| Xu, LM | 1 |
| Pujol, J | 1 |
| Martínez-Vilavella, G | 1 |
| Gallart, L | 1 |
| Blanco-Hinojo, L | 1 |
| Pacreu, S | 1 |
| Bonhomme, V | 2 |
| Deus, J | 1 |
| Pérez-Sola, V | 1 |
| Gambús, PL | 4 |
| Fernández-Candil, J | 1 |
| Zhu, X | 1 |
| He, X | 1 |
| Fan, B | 1 |
| Liu, J | 3 |
| Wu, S | 1 |
| Wang, H | 4 |
| Chen, C | 3 |
| Seyfi, S | 1 |
| Amiri, HA | 1 |
| Banihashem, N | 1 |
| Ezoji, K | 1 |
| Ziaei, SG | 1 |
| Yang, X | 3 |
| Wu, Q | 3 |
| Peng, X | 1 |
| Campos-Pérez, W | 1 |
| Ramírez-Plascencia, L | 1 |
| Pérez-Robles, M | 1 |
| Rivera-Valdés, JJ | 1 |
| Sánchez-Muñoz, P | 1 |
| Pérez-Vargas, L | 1 |
| González-Landeros, D | 1 |
| Cuevas, JHM | 1 |
| Martínez-López, E | 1 |
| van Dijk, H | 1 |
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| van Eck-Smaling, MM | 1 |
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| van Loon, K | 1 |
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| Shieh Yu, J | 1 |
| Slaven, JE | 1 |
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| Estephan, LE | 2 |
| Sussman, S | 1 |
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| Boon, M | 1 |
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| Duarte, F | 1 |
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| Lobo, FA | 1 |
| Tanaka, K | 1 |
| Yoshizumi, Y | 1 |
| Hamada, T | 1 |
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| Mori, T | 1 |
| Wiemann, B | 3 |
| Mitchell, J | 3 |
| Sarangarm, P | 3 |
| Miskimins, R | 3 |
| Strayer, RJ | 3 |
| Zhang, F | 2 |
| Chang, H | 2 |
| Qing, W | 2 |
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| Singh, A | 1 |
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| Ahuja, V | 1 |
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| Datta, PK | 1 |
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| Zhang, H | 4 |
| Yu, Z | 1 |
| Li, D | 1 |
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| Li, S | 2 |
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| Li, X | 3 |
| Yang, J | 3 |
| Crosby, T | 1 |
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| Ezeh, UC | 1 |
| Patil, S | 1 |
| Kwak, PE | 1 |
| Chin, WA | 1 |
| Amin, MR | 1 |
| Soultati, I | 1 |
| Ntenti, C | 1 |
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| Gkinas, D | 1 |
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| Wu, X | 2 |
| Wang, C | 2 |
| Gao, H | 1 |
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| Chen, R | 1 |
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| Feng, Y | 1 |
| Chen, XB | 1 |
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| Chang, P | 1 |
| Zhang, WS | 2 |
| Bauerschmidt, A | 1 |
| Al-Bermani, T | 1 |
| Ali, S | 1 |
| Bass, B | 1 |
| Dorilio, J | 1 |
| Al-Mufti, F | 1 |
| Sagalow, ES | 1 |
| Kumar, AT | 1 |
| Hwang, M | 1 |
| Krein, H | 1 |
| Heffelfinger, R | 1 |
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| Ocampo Benegas, DE | 1 |
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| Butragueño Laiseca, L | 1 |
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| Parreño Marchante, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center, Randomized, Double-Blind, Propofol-Controlled Phase III Clinical Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion for the Induction of Sedation/Anesthesia in Subjects Undergoing Fiberoptic Bronchoscopy[NCT04111159] | Phase 3 | 267 participants (Actual) | Interventional | 2019-12-06 | Completed | ||
| Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery in Elderly Patients Undergoing Gastrointestinal Surgery[NCT05843383] | 280 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | |||
| A Comparison of Opioid-containing Anesthesia Versus Opioid-free Anesthesia Using the Cortínez-Sepúlveda Model on Differential Cytokine Responses in Patients Undergoing Gastric Bypass Surgery[NCT04854252] | 40 participants (Actual) | Interventional | 2020-11-12 | Completed | |||
| 'Study of the Cerebral Effects of Sevoflurane, Propofol and Remifentanil as Measured by the Spontaneous Electro-encephalogram'[NCT02043938] | 46 participants (Actual) | Interventional | 2013-12-16 | Completed | |||
| Pharmacodynamic Interactions Between Remifentanil and Dexmedetomidine (PIRAD)[NCT03143972] | Phase 4 | 30 participants (Actual) | Interventional | 2017-06-28 | Completed | ||
| Electroacupuncture Analgesia for Endoscopic Ultrasound (EUS): a Prospective, Randomized, Double-blinded, Sham-controlled Study[NCT02066194] | Phase 2 | 128 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Multicentered Prospective Randomized Controlled Trial On Contrast-Enhanced Harmonic Endoscopic Ultrasound (CH_EUS) Vs Conventional EUS-Guided Fine Needle Biopsy (FNB) For Solid Pancreatic Lesions[NCT04841616] | 128 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | |||
| Does the Use of a Videolaryngoscope Modifies Anesthetic Induction ?[NCT02245789] | 50 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| Non-interventional Comparison of Sedatives on Weaning From Mechanical Ventilation in Intensive Care Patients[NCT01707680] | 155 participants (Actual) | Observational | 2012-06-01 | Terminated (stopped due to Halted due to slow recruitment) | |||
| Sedation, ANalgesia and Delirium MANagement: a Study of Medical, Surgical, Trauma, and Neuro-intensive Care Patients and a COVID-19 Sub-study.[NCT05027217] | 3,421 participants (Actual) | Observational | 2022-01-01 | Completed | |||
| [NCT02039453] | 160 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | |||
| Physiologic Stress During Procedural Sedation With and Without Alfentanil[NCT00997113] | Phase 4 | 20 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy: Randomized, Prospective Controlled Study[NCT04064047] | 284 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| Assessment of Pain Through Parasympathetic Tone Analysis : Applicability in Children With Cerebral Palsy.[NCT02364856] | 17 participants (Actual) | Observational | 2015-04-24 | Terminated | |||
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| Compatibility of Qnox Values With Hemodynamic Changes as a Predictor of Pain Response in Tracheal Intubation Procedures[NCT04215289] | 54 participants (Actual) | Observational | 2019-11-26 | Completed | |||
| Comparison Between Manual Versus Closed-loop Titration of Propofol and Remifentanil Guided by the qCon and qNox Indexes During Induction and Maintenance of General Anesthesia in Adult Patients: a Multicentre Randomized Controlled Study[NCT03540875] | 62 participants (Actual) | Interventional | 2018-07-02 | Terminated (stopped due to Modification of the device) | |||
| Pain Prevention During Propofol Infusion in Pediatric: Hypnoanalgesia of the Hand Versus Lidocaine.[NCT03453723] | Phase 4 | 100 participants (Actual) | Interventional | 2018-04-18 | Completed | ||
| Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine Combined With Propofol on Tussis Reflection During Upper Gastroscopy: a Randomised, Two Centre, Three-blind, Controlled Trial[NCT05497492] | 400 participants (Anticipated) | Interventional | 2022-11-05 | Recruiting | |||
| Effectiveness of the Distraction Methods on Pain, Anxiety and Satisfaction During Cystoscopy[NCT02764294] | 120 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| Prospective Observational Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio at the Emergency Department of a Tertiary Hospital[NCT04028141] | 61 participants (Actual) | Observational | 2018-02-01 | Completed | |||
| Subanesthetic Sevoflurane for Treatment-Resistant Depression: A Proof-of-Concept Trial[NCT05008939] | 15 participants (Anticipated) | Interventional | 2021-08-31 | Not yet recruiting | |||
| Will Warm Patch on the Injecting Site Decrease the Injection Pain Induced by Propofol[NCT04555980] | 120 participants (Actual) | Interventional | 2020-03-20 | Completed | |||
| Non-anesthesiologist Administered Propofol Sedation for Colonoscopy - a Randomized Clinical Trial[NCT02067065] | 277 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Safety and Efficacy Evaluation of Remimazolam for Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy[NCT05437497] | 264 participants (Anticipated) | Interventional | 2021-08-01 | Recruiting | |||
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Population Pharmacokinetic and Pharmacodynamic Modeling of Microemulsion Propofol in Healthy Volunteers: Comparison With Lipid Emulsion Propofol[NCT00908726] | Phase 1 | 63 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| Influence of Dexmedetomidine and Lidocaine on Opioid Consumption, Cognitive Function and Incidence of Neuropathic Pain in Laparoscopic Intestine Resection[NCT02616523] | Phase 4 | 60 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [NCT01773044] | Phase 4 | 300 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial[NCT01269307] | 99 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| A Randomized Double-blind Trial to Evaluate Ketamine-propofol Combination vs. Propofol Alone for Procedural Sedation and Analgesia in the Emergency Department.[NCT01211158] | Phase 3 | 284 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery[NCT01227174] | Phase 4 | 169 participants (Anticipated) | Interventional | 2011-01-31 | Not yet recruiting | ||
| Comparison of Intubation Conditions After Induction With Propofol Associated With a Dose of Remifentanil or Sufentanil in Surgical Tooth Extraction.[NCT01910285] | Phase 4 | 70 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial[NCT00228267] | Phase 2 | 28 participants (Anticipated) | Interventional | 2004-09-30 | Completed | ||
| Optimal Lidocaine Propofol Mixture for Painless Induction of Anesthesia[NCT05898061] | 100 participants (Anticipated) | Observational [Patient Registry] | 2023-03-01 | Recruiting | |||
| Same Day Bidirectional Endoscopies - Does the Sequence of Procedures or Choice of Insufflator Matter?[NCT02635217] | 200 participants (Actual) | Interventional | 2016-01-31 | Completed | |||
| [NCT01491126] | 170 participants (Anticipated) | Observational | 2012-01-31 | Not yet recruiting | |||
| Neuroplasticity Induced by General Anaesthesia[NCT04125121] | 20 participants (Actual) | Interventional | 2019-09-26 | Completed | |||
| [NCT01966198] | 10 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Validity of Pain Threshold Index Based on Electroencephalogram for Pediatric Patients Under General Anesthesia[NCT03622242] | 180 participants (Anticipated) | Interventional | 2018-08-13 | Recruiting | |||
| The Comparison of Two Different Techniques of Remifentanil Consumption During Implantable Vascular Access Device Procedures[NCT04749069] | 107 participants (Actual) | Interventional | 2012-08-01 | Completed | |||
| Dexmedetomidine Compared to Midazolam for Symptom Control in Advanced Cancer Patients: A Pilot Randomized Controlled Trial (RCT)[NCT01687751] | Phase 2 | 0 participants (Actual) | Interventional | 2012-11-30 | Withdrawn (stopped due to Study design determined to be not likely feasible) | ||
| Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection[NCT03134612] | Phase 2 | 104 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Comparison of Ketamine-propofol Sedation Protocols With Fentanyl-propofol Administered by Endoscopist or Anesthesiologist at Colonoscopy[NCT03607110] | 120 participants (Actual) | Observational | 2018-03-01 | Completed | |||
| Patient-Controlled Sedation in Port Implantation (PACSPI-2) -a Randomized Controlled Trial[NCT05688384] | Phase 4 | 340 participants (Anticipated) | Interventional | 2023-01-19 | Recruiting | ||
| Prospective, Monocentric Controlled, Randomized, Double-blind Study to Compare the Two Different Propofol Emulsions Regarding Tolerability and Injection Pain During the Induction of Anesthesia in Adults[NCT00690495] | Phase 3 | 100 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| The Effect of Preoperative Anxiolysis With Intravenous Midazolam on Intraoperative Sevoflurane Gas Consumption: A Prospective Randomized Controlled Study[NCT05371600] | Phase 4 | 80 participants (Anticipated) | Interventional | 2022-12-02 | Recruiting | ||
| A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966] | 93 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant[NCT02819089] | 100 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | |||
| Smart Pain Assesment Tool Based on Internet of Things[NCT03061240] | 58 participants (Actual) | Interventional | 2017-11-20 | Completed | |||
| Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction: a Double-Blind, Multicenter, Randomized, Placebo-Controlled Clinical Trial[NCT04912518] | 250 participants (Anticipated) | Interventional | 2021-05-27 | Recruiting | |||
| Efficacy and Safety of Dexmedetomidine Combined With Butorphanol Tartrate for Postoperative Analgesia and Breastfeeding in Cesarean Section[NCT03065530] | Phase 4 | 120 participants (Actual) | Interventional | 2017-02-07 | Completed | ||
| A Prospective, Multi-centre, Randomised, Double-blind Comparison of Intravenous Dexmedetomidine With Midazolam for Continuous Sedation of Ventilated Patients in Intensive Care Unit[NCT00481312] | Phase 3 | 501 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Low-dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Patients in Intensive Care Unit: a Multicenter, Randomised, Double-blinded, Placebo-controlled Trial[NCT03172897] | Phase 4 | 260 participants (Anticipated) | Interventional | 2017-08-20 | Suspended (stopped due to The trial was stopped because of difficulty in recruiting patients (another trial had similar inclusion/exclusion criteria). No patients was recruited in this trial.) | ||
| Comparative Study on Development of Paradoxical Excitement Response During Sedation Using Dexmedetomidine or Propofol in Hazardous Alcohol Drinkers[NCT02197403] | Phase 4 | 110 participants (Anticipated) | Interventional | 2013-12-31 | Recruiting | ||
| A Prospective, Multi-centre, Randomised, Double-blind Comparison of Intravenous Dexmedetomidine With Propofol for Continuous Sedation of Ventilated Patients in Intensive Care Unit[NCT00479661] | Phase 3 | 500 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| PRO-DEFENSE: Propofol Versus Dexmedetomidine for Sedation in Mechanically Ventilated Patients With Sepsis[NCT02203019] | Phase 4 | 36 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Pain, Agitation and Delirium Protocol in Ventilated Patients in the Duke CICU[NCT02903407] | Phase 4 | 7 participants (Actual) | Interventional | 2017-09-01 | Terminated (stopped due to All enrolled participants completed the study protocol but the study was terminated prior to the goal number of participants due to low recruitment) | ||
| EEG-based Depth of Anesthesia-monitoring During General Anesthesia - Effects on Time to Wake-up and Post-operative Cognition[NCT04529304] | 100 participants (Anticipated) | Interventional | 2021-01-08 | Recruiting | |||
| Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia[NCT00137111] | Phase 3 | 501 participants (Actual) | Interventional | 2000-07-08 | Completed | ||
| Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain: a Randomized Controlled Trial[NCT02421913] | Phase 4 | 42 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Goal Directed Propofol Sedation With Magnesium Sulphate Versus Dexmedetomidine for ERCP Procedure[NCT02684019] | Phase 3 | 60 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894] | 124 participants (Actual) | Observational | 2016-09-07 | Completed | |||
| Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department[NCT01387139] | Phase 3 | 183 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Comparative Study Between Intravenous Nalbuphine Versus Intravenous Dexmedetomidine for Conscious Sedation in Patients Undergoing Colonoscopy[NCT05689242] | Phase 4 | 66 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | ||
| The Pharmacokinetics of Fentanyl in Intensive Care Patients[NCT02587273] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | ||
| Comparison of the Bispectral Index and the Entropy of the Electroencephalogram During Total Intravenous Anesthesia[NCT00391963] | 84 participants | Observational | 2006-06-30 | Completed | |||
| Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures[NCT05294640] | Phase 4 | 95 participants (Actual) | Interventional | 2022-05-17 | Completed | ||
| A Comparison of Injection Pain of Propofol During Endoscopy : LCT Propofol vs MCT/LCT Propofol[NCT02567916] | Phase 4 | 129 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Efficacy of Alfentanyl Versus Sufentanyl in Children for Pain During Treatment by Tracheal Suction in an Intensive Care Unit.[NCT01235637] | Phase 3 | 40 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Optimal Dose of Combination of Rocuronium and Cisatracurium: A Randomized Double-blinded Clinical Trial[NCT02495038] | 81 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| The Impact of the Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain in Gynecologic Laparoscopic Surgery-prospective and Controlled Study.[NCT04547608] | 100 participants (Actual) | Interventional | 2020-05-01 | Completed | |||
| Vibration Analgesia in Propofol Infusion During Anesthesia Induction[NCT03509857] | 100 participants (Actual) | Interventional | 2019-02-01 | Completed | |||
| Intravenous Sedation and Analgesia Using Propofol, Fentanyl and Ketamine (PFK) Versus General Anesthesia in Minor Urological Procedures.[NCT04285528] | 200 participants (Actual) | Interventional | 2019-04-17 | Completed | |||
| Comparison of Remifentanil and Dexmedetomidine for Monitored Anaesthesia Care[NCT02476981] | 75 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Patient State Index (PSI-1) is a processed EEG parameter that quantifies the level of EEG inhibition. A new algorithm (PSI-2) has been created to improve performance in low power EEG. PSI is unitless. It ranges between 100 and 0 (100 representing 'awake state', 0 denoting 'no detectable electrical brain activity'). PSI-1 and PSI-2 were compared in their correlation with measured propofol and sevoflurane concentrations with or without remifentanil (0, 2 ,or 4 ng/mL) via several estimated PD model parameters. In the data table, BL (Baseline) denotes PSI-2 measurements when no drug is present; Emax denotes PSI in the presence of the maximum drug effect; C50 is the drug concentration which produces 50% of the maximal drug effect (ug/mL for Propofol C50, vol% for Sevoflurane C50). (NCT02043938)
Timeframe: 6 weeks
| Intervention | index (Mean) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No Drugs, PSI-2 (BL) | P, PSI-2 (Emax) | PR, PSI-2 (Emax) | S, PSI-2 (Emax) | SR, PSI-2 (Emax) | No Drugs, PSI-1 (BL) | P, PSI-1 (Emax) | PR, PSI-1 (Emax) | S, PSI-1 (Emax) | SR, PSI-1 (Emax) | |
| Healthy Volunteers | 85.1 | 63.1 | 63.1 | 67.2 | 67.2 | 85.1 | 63.1 | 63.1 | 0.152 | 0.152 |
Patient State Index (PSI-1) is a processed EEG parameter that quantifies the level of EEG inhibition. A new algorithm (PSI-2) has been created to improve performance in low power EEG. PSI is unitless. It ranges between 100 and 0 (100 representing 'awake state', 0 denoting 'no detectable electrical brain activity'). PSI-1 and PSI-2 were compared in their correlation with measured propofol and sevoflurane concentrations with or without remifentanil (0, 2 ,or 4 ng/mL) via several estimated PD model parameters. In the data table, BL (Baseline) denotes PSI-2 measurements when no drug is present; Emax denotes PSI in the presence of the maximum drug effect; C50 is the drug concentration which produces 50% of the maximal drug effect (ug/mL for Propofol C50, vol% for Sevoflurane C50). (NCT02043938)
Timeframe: 6 weeks
| Intervention | ug/mL (Mean) | |||
|---|---|---|---|---|
| P, PSI-2 (C50) | PR, PSI-2 (C50) | P, PSI-1 (C50) | PR, PSI-1 (C50) | |
| Healthy Volunteers | 1.63 | 1.63 | 1.63 | 1.63 |
Patient State Index (PSI-1) is a processed EEG parameter that quantifies the level of EEG inhibition. A new algorithm (PSI-2) has been created to improve performance in low power EEG. PSI is unitless. It ranges between 100 and 0 (100 representing 'awake state', 0 denoting 'no detectable electrical brain activity'). PSI-1 and PSI-2 were compared in their correlation with measured propofol and sevoflurane concentrations with or without remifentanil (0, 2 ,or 4 ng/mL) via several estimated PD model parameters. In the data table, BL (Baseline) denotes PSI-2 measurements when no drug is present; Emax denotes PSI in the presence of the maximum drug effect; C50 is the drug concentration which produces 50% of the maximal drug effect (ug/mL for Propofol C50, vol% for Sevoflurane C50). (NCT02043938)
Timeframe: 6 weeks
| Intervention | %vol (Mean) | |||
|---|---|---|---|---|
| S, PSI-2 (C50) | SR, PSI-2 (C50) | S, PSI-1 (C50) | SR, PSI-1 (C50) | |
| Healthy Volunteers | 1.22 | 1.22 | 1.22 | 1.22 |
For all study groups (i.e. P, S, PR, and SR), the estimated PD model parameters that represent remifentanil interactions are Theta1 and Theta2, which are unit-less values. Theta1 and Theta2 are zero for all volunteers not receiving remifentanil. In case an interaction between remifentanil and propofol or sevoflurane exists, the estimate for Theta1 will be significantly different from zero. If the interaction in the 4 ng/mL group exceeds the estimated interaction for the 2 ng/mL group, Theta2 will be significantly higher than zero. (NCT02043938)
Timeframe: 6 weeks
| Intervention | Index (Mean) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Theta1, PSI-2 (P) | Theta1, PSI-2 (S) | Theta1, PSI-2 (PR 2ng/mL) | Theta1, PSI-2 (SR 2ng/mL) | Theta1, PSI-1 (P) | Theta1, PSI-1 (S) | Theta1, PSI-1 (PR 2ng/mL) | Theta1, PSI-1 (SR 2ng/mL) | Theta2, PSI-2 (P) | Theta2, PSI-2 (S) | Theta2, PSI-2 (PR 4ng/mL) | Theta2, PSI-2 (SR 4ng/mL) | Theta2, PSI-1 (P) | Theta2, PSI-1 (S) | Theta2, PSI-1 (PR 4ng/mL) | Theta2, PSI-1 (SR 4ng/mL) | |
| Healthy Volunteers | 0 | 0 | -0.135 | -0.135 | 0 | 0 | -0.135 | -0.135 | 0 | 0 | 0.816 | 0.816 | 0 | 0 | 0.816 | 0.816 |
change in serum catecholamine levels, values indicate a decrease over the procedure. These patients underwent fracture reduction procedures which are typically associated with an increase in catecholamines. (NCT00997113)
Timeframe: one minute prior to the start of the procedure and immediately at the end of sedation procedure (median time of procedure 12 minutes range 6-26 minutes
| Intervention | mcg/ml (Median) |
|---|---|
| Propofol | 87 |
| Propofol/Alfentanil | 106 |
Pain and recall were measured seperately by direct patient query. The patient was asked if they experienced any pain during the procedure. The patient was then asked if they could recall any part of the fracture reduction. Patients who had either pain with the procedure of recall of the procedure were counted as having pain or recall with the procedure. (NCT00997113)
Timeframe: single time point measured after sedation procedure completed
| Intervention | participants (Number) |
|---|---|
| Propofol | 2 |
| Propofol/Alfentanil | 5 |
categorized as a change in end tidal CO2 from baseline >10mmhg, a loss of end tidal CO2 waveform for more than 6 seconds, or an oxygen saturation less than 93%. (NCT00997113)
Timeframe: From one minute prior to the start of the sedation procedure until the patient has returned to baseline mental status
| Intervention | participants (Number) |
|---|---|
| Propofol | 4 |
| Propofol/Alfentanil | 5 |
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
consumption of fentanyl (mg) during the procedure (NCT02616523)
Timeframe: time of the operation
| Intervention | mg (Mean) |
|---|---|
| Dexmedetomidine | 41 |
| Lidocaine | 50 |
| Placebo | 58 |
consumption of piritramide (mg) in the recovery room (NCT02616523)
Timeframe: one hour after the operation
| Intervention | mg (Mean) |
|---|---|
| Dexmedetomidine | 4.63 |
| Lidocaine | 5.25 |
| Placebo | 4.25 |
Pain questionnaire dn4 will be send to participants after two months of surgery to evaluate the neuropathic pain. There are minimum 0 points and maximum 10 points. If the score is 4 or higher then the pain is likely to be neuropathic pain. (NCT02616523)
Timeframe: two months after the surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Dexmedetomidine | 0.11 |
| Lidocaine | 0.00 |
| Placebo | 0.45 |
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
(NCT00690495)
Timeframe: during first propofol bolus
| Intervention | participants (Number) |
|---|---|
| Modified Propofol | 1 |
| Propofol 1% | 7 |
We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)
| Intervention | units on a scale (Mean) |
|---|---|
| Lavender Oil | 0.89 |
| Placebo | .74 |
Total times during 48h after cesarean section. (NCT03065530)
Timeframe: 48h after cesarean section.
| Intervention | participants (Number) |
|---|---|
| Group C | 1 |
| Group D1 | 2 |
| Group D2 | 1 |
| Group D3 | 1 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS at rest was assessed when the patient was in supine position (NCT03065530)
Timeframe: 48h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 2.11 |
| Group D1 | 2 |
| Group D2 | 1.72 |
| Group D3 | 125 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS at rest was assessed when the patient was in supine position (NCT03065530)
Timeframe: 12h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.29 |
| Group D1 | 2.86 |
| Group D2 | 1.62 |
| Group D3 | 0.93 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS at rest was assessed when the patient was in supine position (NCT03065530)
Timeframe: 24h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.21 |
| Group D1 | 2.93 |
| Group D2 | 1.72 |
| Group D3 | 1.57 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS at rest was assessed when the patient was in supine position (NCT03065530)
Timeframe: 6h after cesarean section.
| Intervention | units on a scale (Mean) |
|---|---|
| Group C | 3.143 |
| Group D1 | 2.897 |
| Group D2 | 1.665 |
| Group D3 | 1.25 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS on movement was assessed when patients changed from supine to lateral position. (NCT03065530)
Timeframe: 12h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.71 |
| Group D1 | 3.52 |
| Group D2 | 2.69 |
| Group D3 | 1.18 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS on movement was assessed when patients changed from supine to lateral position. (NCT03065530)
Timeframe: 24h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.82 |
| Group D1 | 3.79 |
| Group D2 | 2.35 |
| Group D3 | 1.93 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS on movement was assessed when patients changed from supine to lateral position. (NCT03065530)
Timeframe: 48h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.43 |
| Group D1 | 3.28 |
| Group D2 | 2.24 |
| Group D3 | 1.21 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS on movement was assessed when patients changed from supine to lateral position. (NCT03065530)
Timeframe: 6h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 4.39 |
| Group D1 | 4.31 |
| Group D2 | 2.86 |
| Group D3 | 2.2 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS-C was assessed when the patient required oxytocin after surgery in supine position (NCT03065530)
Timeframe: 12h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.46 |
| Group D1 | 3.41 |
| Group D2 | 2.17 |
| Group D3 | 1.07 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS-C was assessed when the patient required oxytocin after surgery in supine position (NCT03065530)
Timeframe: 24h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.75 |
| Group D1 | 3.55 |
| Group D2 | 2.59 |
| Group D3 | 1.79 |
visual analogue scale (VAS; with 0, no pain; to 10, the worst imaginable pain) is a validated assessing scale for pain intensity. VAS-C was assessed when the patient required oxytocin after surgery in supine position (NCT03065530)
Timeframe: 6h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 3.86 |
| Group D1 | 3.66 |
| Group D2 | 2.79 |
| Group D3 | 2 |
Sedation intensity measured with RSS is recorded at the 6, 12 24 and 48 h after cesarean section. Sedation was assessed by the Ramsay Sedation Scores (RSS) (1, anxious patient; 2, cooperative and tranquil; 3, responding to command; 4, brisk response to stimulus; 5, sluggish response to stimulus; 6, no response to stimulus). (NCT03065530)
Timeframe: 6h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Control Group | 2 |
| Dexmedetomidine 0.03ug/kg/h Group | 2.17 |
| Dexmedetomidine 0.05ug/kg/h Group | 2.14 |
| Dexmedetomidine 0.08ug/kg/h Group | 3.14 |
Sedation intensity measured with RSS is recorded at the 6, 12, 24, and 48 h after cesarean section. Sedation was assessed by the Ramsay Sedation Scores (RSS) (1, anxious patient; 2, cooperative and tranquil; 3, responding to command; 4, brisk response to stimulus; 5, sluggish response to stimulus; 6, no response to stimulus). (NCT03065530)
Timeframe: 12h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 2 |
| Group D1 | 2.21 |
| Group D2 | 2.28 |
| Group D3 | 3.21 |
Sedation intensity measured with RSS is recorded at the 6, 12, 24, and 48 h after cesarean section. Sedation was assessed by the Ramsay Sedation Scores (RSS) (1, anxious patient; 2, cooperative and tranquil; 3, responding to command; 4, brisk response to stimulus; 5, sluggish response to stimulus; 6, no response to stimulus). (NCT03065530)
Timeframe: 24h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 2 |
| Group D1 | 2.07 |
| Group D2 | 2.10 |
| Group D3 | 2.25 |
Sedation intensity measured with RSS is recorded at the 6, 12, 24, and 48 h after cesarean section. Sedation was assessed by the Ramsay Sedation Scores (RSS) (1, anxious patient; 2, cooperative and tranquil; 3, responding to command; 4, brisk response to stimulus; 5, sluggish response to stimulus; 6, no response to stimulus). (NCT03065530)
Timeframe: 48h after cesarean section.
| Intervention | score on a scale (Mean) |
|---|---|
| Group C | 2 |
| Group D1 | 2 |
| Group D2 | 2 |
| Group D3 | 2 |
Relative infant dose (RID) =Dose (infant, mg•kg-1•day-1) /Dose (mother, mg•kg-1•day-1) μg·kg-1·h-1. The Dose (infant) in mg•kg-1 is calculated by multiplying the concentration of the drug in breast milk by the volume of breast milk consumed daily (about 150 mL•kg-1). (NCT03065530)
Timeframe: 48h after cesarean section.
| Intervention | percentage of one hundred (Mean) |
|---|---|
| Group D1 | 0.1712 |
| Group D2 | 0.1967 |
| Group D3 | 0.3701 |
The degree of satisfaction (0, very satisfied; 1, satisfied; 2, moderately satisfied; 3, not satisfied) was evaluated at 48 h after surgery. The number of overall satisfied patients (satisfied and very satisfied) is reported. (NCT03065530)
Timeframe: 48h after cesarean section.
| Intervention | Participants (Count of Participants) |
|---|---|
| Group C | 12 |
| Group D1 | 16 |
| Group D2 | 26 |
| Group D3 | 25 |
Number of days patient requires mechanical ventilation (NCT02203019)
Timeframe: Up to 28 days
| Intervention | days (Median) |
|---|---|
| Propofol | 5 |
| Dexmedetomidine | 3 |
Number of days patient stays in the MICU (NCT02203019)
Timeframe: Up to 28 Days
| Intervention | days (Median) |
|---|---|
| Propofol | 6 |
| Dexmedetomidine | 5 |
Number of days the patient requires intravenous vasopressors (NCT02203019)
Timeframe: Up to 28 Days
| Intervention | days (Median) |
|---|---|
| Propofol | 0 |
| Dexmedetomidine | 2 |
Number of patients who die within 28 days after randomization (NCT02203019)
Timeframe: Up to 28 Days
| Intervention | Participants (Count of Participants) |
|---|---|
| Propofol | 8 |
| Dexmedetomidine | 9 |
Index hospitalization length of stay in days (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Days (Median) |
|---|---|
| Midazolam | 19.5 |
| Propofol or Dexmedetomidine | 30.0 |
All-cause mortality during the hospitalization (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | participants (Number) |
|---|---|
| Midazolam | 1 |
| Propofol or Dexmedetomidine | 1 |
Number of days of admission to the CICU during the index hospitalization (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Days (Median) |
|---|---|
| Midazolam | 4.1 |
| Propofol or Dexmedetomidine | 10.0 |
The number of days alive and free from delirium or coma during admission will be evaluated among patients with CAM-ICU documented (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Days (Median) |
|---|---|
| Midazolam | 14.0 |
The time (in days) from when the clinical care team documents a decision to pursue extubation until the time the patient was extubated (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Days (Median) |
|---|---|
| Midazolam | 0 |
| Propofol or Dexmedetomidine | 0 |
Following ICU discharge, patient charts will be reviewed to evaluate whether they required reintubation. If so, will determine whether necessity of reintubation was related to delirium. (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Participants (Count of Participants) |
|---|---|
| Midazolam | 0 |
| Propofol or Dexmedetomidine | 1 |
Patients will be monitored for bradycardia which may be associated with sedation drug. Average heart rate before, during and after use of drug will be recorded for each patient. (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Participants (Count of Participants) |
|---|---|
| Midazolam | 0 |
| Propofol or Dexmedetomidine | 0 |
Will use the Confusion Assessment Method for the ICU (CAM-ICU) to assess presence of delirium as per standard of care by nurses in the CICU. Patients with CAM-ICU data recorded will be included. (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Participants (Count of Participants) |
|---|---|
| Midazolam | 1 |
Patients will be monitored for increased pressor requirement during the CICU stay (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Participants (Count of Participants) |
|---|---|
| Midazolam | 2 |
| Propofol or Dexmedetomidine | 2 |
Days requiring mechanical ventilation during the initial episode of intubation during the hospitalization (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Days (Median) |
|---|---|
| Midazolam | 2.5 |
| Propofol or Dexmedetomidine | 6.8 |
Will use the CPOT (Critical-Care Pain Observation Tool) score to assess pain level as per standard of care by nurses in the CICU. The CPOT has a range of 0 to 8. A CPOT score of ≤ 2 = minimal to no pain present and >2 = unacceptable level of pain. Data that is recorded will be evaluated following discharge. (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | score on a scale (Median) |
|---|---|
| Midazolam | 0.0 |
| Propofol or Dexmedetomidine | 0.0 |
Will use RASS (Richmond Agitation and Sedation Scale) to assess level of sedation as per standard of care by nurses in the CICU. Data that is recorded will be evaluated following discharge. The RASS ranges from -5 (unrousable) to +4 (combative) and 0 (zero) = alert and calm and goal sedation is considered a RASS level of 0 to -2. (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | percentage of time (Median) |
|---|---|
| Midazolam | 63.3 |
| Propofol or Dexmedetomidine | 63.2 |
The duration, in days, from withdrawal of sedation for mechanical ventilation until the time of discharge from the ICU (NCT02903407)
Timeframe: One month or hospital discharge, whichever time point comes first
| Intervention | Days (Median) |
|---|---|
| Midazolam | 1.6 |
| Propofol or Dexmedetomidine | 5.6 |
"White blood cell (leukocytes) counts in peripheral blood by Complete Blood Count~Measurement: Percentage change of leukemia cells from baseline" (NCT00137111)
Timeframe: Immediately before the methotrexate infusion and three days after subsequent infusion
| Intervention | Percent change (Mean) |
|---|---|
| 4 hr | -44 |
| 24 hr | -50 |
CCR was measured from end of week 56 therapy to the date of first treatment failure of any kind (relapse, death, lineage switch, or second malignancy) or to the last date of follow-up. Measurement was determined by Kaplan-Meyer estimate. (NCT00137111)
Timeframe: Median follow up time (range) 4.5 (1 to 7.8) years
| Intervention | Percentage of participants (Number) |
|---|---|
| Patients With High Risk of CNS Relapse | 92.2 |
Children were randomly assigned to receive initial single-agent treatment with HDMTX (1g/m^2) as either a 24-hour infusion or a 4-hour infusion and the outcome measure was the accumulation of MTXPG in leukemia cells. (NCT00137111)
Timeframe: 42 hours after start of high dose methotrexate infusion (HDMTX)
| Intervention | pmol/1,000,000,000 cells (Mean) |
|---|---|
| 4 hr | 1688 |
| 24 hr | 2521 |
EFS was measured from the start of on-study to the date of first treatment failure of any kind (relapse, death, lineage switch, or second malignancy) or to the last date of follow-up. Failure to enter remission was considered an event at time zero. Measurement was determined by Kaplan-Meyer estimate. (NCT00137111)
Timeframe: Median follow-up time (range) 5.6 (1.3 to 8.9) years
| Intervention | Percentage of Participants (Number) |
|---|---|
| Total Therapy | 87.3 |
Prednisolone sensitivity was measured in primary leukemia cells from bone marrow collected at diagnosis. Expression of CASP1 was determined by HG-U133A microarray. Values given are gene expression values, and the unit is arbitrary units (AU) defined as scaled fluorescence measured on microarray. (NCT00137111)
Timeframe: Pre-treatment
| Intervention | arbitrary units (Median) | |
|---|---|---|
| Prednisolone-sensitive cells | Prednisolone-resistant cells | |
| Total Therapy | 341.3 | 447.9 |
Prednisolone sensitivity was measured in primary leukemia cells from bone marrow collected at diagnosis. Expression of NLRP3 was determined by HG-U133A microarray. Values given are gene expression values, and the unit is arbitrary units (AU) defined as scaled fluorescence measured on microarray. (NCT00137111)
Timeframe: Pre-treatment
| Intervention | arbitrary units (Median) | |
|---|---|---|
| Prednisolone-sensitive cells | Prednisolone-resistant cells | |
| Total Therapy | 41.2 | 110.7 |
Detection of MRD at end of induction where positive MRD was defined as one or more leukemic cell per 10,000 mononuclear bone-marrow cells (>=0.01%). (NCT00137111)
Timeframe: End of Induction (Day 46 MRD measurement)
| Intervention | participants (Number) | |
|---|---|---|
| Negative <0.01% | Positive >= 0.01% | |
| Total Therapy | 390 | 102 |
"Efficacy is defined as:~The patient does not have unpleasant recall of the procedure.~The patient did not experience sedation-related adverse events resulting in abandonment of the procedure or a permanent complication or an unplanned admission to the hospital or prolonged emergency department (ED) observation~The patient did not actively resist or require physical restraint for completion of the procedure. The need for minimal redirection of movements should not be considered as active resistance or physical restraint.~The procedure was successful" (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | participants (Number) |
|---|---|
| Ketamine Alone | 97 |
| Ketamine Co-Administered With Propofol | 81 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 8 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (1-10) (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 10 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 9 |
| Ketamine Co-Administered With Propofol | 8 |
Time until the patient has a Vancouver Sedation Recovery Scale Score of 18 or greater. (NCT01387139)
Timeframe: Once Vancouver Sedation Recovery Scale Score reaches 18 or greater, on average less than 1 hour
| Intervention | minutes (Median) |
|---|---|
| Ketamine Alone | 44 |
| Ketamine Co-Administered With Propofol | 43.5 |
We will record all adverse events during the sedation, and then perform a follow-up call to determine if any additional adverse events occured after discharge. (NCT01387139)
Timeframe: From enrollment through completion of follow-up, up to 7 days
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Respiratory depression | Cardiovascular event | vomiting/retching | Unpleasant recovery reaction | |
| Ketamine Alone | 12 | 1 | 21 | 4 |
| Ketamine Co-Administered With Propofol | 15 | 0 | 18 | 2 |
Additional Rescue Doses Per Hour Ratio is the number per hour of addition of rescue dose administrated with 10% of initial NMBAs dose. The formula is {(Addition number + 1 / Anesthetic time) x 60}. (NCT02495038)
Timeframe: Intraoperative, an average of 3 hours.
| Intervention | ratio (Mean) |
|---|---|
| Intubating Dose, Group I | 1.43455 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 1.21014 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 0.82128 |
Time from induction to recovery of anesthesia, asessed up to 3 hours. (NCT02495038)
Timeframe: Intraoperative, an average 4 hours.
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 163.0 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 159.9 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 161.4 |
"The BIS monitor provides a single dimensionless number, which ranges from 0 (equivalent to EEG silence) to 100. A BIS value between 40 and 60 indicates an appropriate level for general anesthesia, as recommended by the manufacturer.~Before induction of anesthesia, bispectral index was measured for baseline. And after injection of NMBAs, bispectral index was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | BIS score (Mean) |
|---|---|
| Intubating Dose, Group I | 46.0 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 46.1 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 44.3 |
"Before induction of anesthesia, body temperature was measured for baseline by oral temperature probe.~And after injection of NMBAs, non invasive blood pressure was measured at 10 min by esophageal temperature probe." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | Celcius degree (Mean) |
|---|---|
| Intubating Dose, Group I | 36.3 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 36.3 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 36.3 |
Time from administration of initial NMBAs to Train-of-four (TOF) ratio >25%, assessed up to 2 hours during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 1 hours
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 51.3 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 47.9 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 39.4 |
Time from administration of initial NMBAs to Train-of-four (TOF) ratio=0, assessed up to 15 minutes during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 5 minutes
| Intervention | Second (Mean) |
|---|---|
| Intubating Dose, Group I | 212.8 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 230.1 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 399.3 |
Time from skin incision to wound dressing assessed up to 8 hours. (NCT02495038)
Timeframe: Intraoperative, an average of 3 hours.
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 151.8 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 147.0 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 145.9 |
"Before induction of anesthesia, peripheral oxygen saturation was measured for baseline.~And after injection of NMBAs, peripheral oxygen saturation was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | Percentage (Mean) |
|---|---|
| Intubating Dose, Group I | 100 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 99.9 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 100 |
Time from TOF ratio 25% to 75%, assessed up to 1 hour during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 20 minutes
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 15.9 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 16.2 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 14.1 |
"Before induction of anesthesia, non invasive blood pressure was measured for baseline.~And after injection of NMBAs, non invasive blood pressure was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | mmHg (Mean) | |
|---|---|---|
| Systolic pressure | Diastolic pressure | |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 128.3 | 76.7 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 128.4 | 74.8 |
| Intubating Dose, Group I | 128.3 | 75.6 |
Patient pain will be assessed by two independent observers, an attending anesthesiologist and a certified registered nurse anesthetist (CRNA). Pain was graded using a four-point pain manifestation scale described by McCrirrick & Hunter : 0 = none (negative response to questioning), 1 = mild (pain reported in response to questioning only, without any behavioral signs), 2 = moderate (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning), 3 = severe (strong vocal response or response accompanied by facial grimacing, arm withdrawal or tears). Higher scores meaning worse outcome (perceived pain) and lower score meaning better outcome. (NCT03509857)
Timeframe: Day 1 at time of propofol injection
| Intervention | units on a scale (Mean) |
|---|---|
| Control Group | 3.1 |
| Treatment Group | 1.4 |
48 reviews available for propofol and Pain
| Article | Year |
|---|---|
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Management of Pain and Agitation in Trauma.
Topics: Analgesics, Opioid; Humans; Ketamine; Multiple Trauma; Pain; Propofol | 2023 |
Comparison of remimazolam and propofol about safety outcome indicators during general anesthesia in surgical patients: a systematic review and meta-analysis.
Topics: Anesthesia, General; Benzodiazepines; Dizziness; Humans; Hypnotics and Sedatives; Hypotension; Hypox | 2023 |
Propofol decreased the etomidate-induced myoclonus in adult patients: a meta-analysis and systematic review.
Topics: Adult; Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Etomidate; Humans; Myoc | 2023 |
Modern Sedation and Analgesia Strategies in Neurocritical Care.
Topics: Analgesia; Critical Care; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Pa | 2023 |
Low-dose ketamine or opioids combined with propofol for procedural sedation in the emergency department: a systematic review.
Topics: Analgesics, Opioid; Conscious Sedation; Emergency Service, Hospital; Fentanyl; Humans; Hypnotics and | 2023 |
Remimazolam
Topics: Anesthesia; Benzodiazepines; Bradycardia; Conscious Sedation; Dizziness; Humans; Hypotension; Pain; | 2023 |
Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis.
Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain; Propof | 2023 |
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed | 2019 |
Dexmedetomidine for prevention of propofol injection pain upon induction of anesthesia: a meta-analysis.
Topics: Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Intravenous; Dexmedetomidine; Humans; Pain; Propo | 2020 |
Pharmacological control of pain during propofol injection: a systematic review and meta-analysis.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Humans; Injections; Lidocaine; Pain; Propofol; | 2021 |
[Propofol up2date].
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Conscious Sedation; Critical | 2013 |
Current methods of analgesia for transrectal ultrasonography (TRUS)-guided prostate biopsy -- a systematic review.
Topics: Administration, Rectal; Analgesia; Anesthesia, Local; Anesthetics, Local; Biopsy; Diclofenac; Gels; | 2014 |
Anesthetic-induced pain on injection in electroconvulsive therapy: review of the literature and suggestions for prevention.
Topics: Anesthesia, General; Anesthetics, Intravenous; Electroconvulsive Therapy; Humans; Methohexital; Pain | 2014 |
Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol injection: a systematic review and meta-analysis.
Topics: Clinical Trials as Topic; Flurbiprofen; Humans; Pain; Propofol; Publication Bias; Risk Factors; Trea | 2014 |
Ability of a meta-analysis to prevent redundant research: systematic review of studies on pain from propofol injection.
Topics: Humans; Injections, Intravenous; Meta-Analysis as Topic; Pain; Propofol; Randomized Controlled Trial | 2014 |
Ketamine-Propofol Versus Propofol Alone for Procedural Sedation in the Emergency Department: A Systematic Review and Meta-analysis.
Topics: Conscious Sedation; Drug Therapy, Combination; Emergency Service, Hospital; Humans; Hypnotics and Se | 2015 |
5-HT3 Receptor Antagonists for Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials.
Topics: Anesthetics, Intravenous; Humans; Injections, Intravenous; Pain; Propofol; Randomized Controlled Tri | 2016 |
Lidocaine for reducing propofol-induced pain on induction of anaesthesia in adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesiology; Anesthetics, Intravenous; An | 2016 |
[Meta analysis for the anesthesia effect and adverse reactions of etomidate and propofol on
the painless abortion surgery].
Topics: Abortion, Induced; Anesthesia; Anesthetics, Intravenous; China; Etomidate; Female; Humans; Pain; Pre | 2016 |
The Comparison of Etomidate and Propofol Anesthesia in Patients Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis.
Topics: Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Arterial Pressure; Colonoscopy; Endosco | 2017 |
Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials.
Topics: Adolescent; Alfentanil; Anesthetics, Intravenous; Anesthetics, Local; Child; Double-Blind Method; Hu | 2017 |
Pain on injection with microemulsion propofol.
Topics: Adult; Aged; Aged, 80 and over; Bradykinin; Chromatography, High Pressure Liquid; Emulsions; Female; | 2009 |
Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists.
Topics: Acetaminophen; Age Factors; Analgesics; Anesthesiology; Biological Availability; Cyclooxygenase Inhi | 2008 |
Pharmacology of commonly used analgesics and sedatives in the ICU: benzodiazepines, propofol, and opioids.
Topics: Analgesics; Analgesics, Opioid; Benzodiazepines; Critical Care; Humans; Hypnotics and Sedatives; Int | 2009 |
Analgosedation in neonates: do we still need additional tools after 30 years of clinical research?
Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Analgesia; Analgesics, Opioid; Dexmedetomidine; | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
Prevention of pain on injection of propofol: systematic review and meta-analysis.
Topics: Adult; Anesthetics, Intravenous; Bias; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pai | 2011 |
The EEG signal: a window on the cortical brain activity.
Topics: Adult; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebral Cortex; Child; | 2012 |
[Fospropofol: A new prodrug of propofol].
Topics: Adult; Anesthetics; Biological Availability; Biotransformation; Clinical Trials, Phase III as Topic; | 2012 |
Ketamine, propofol, and ketofol use for pediatric sedation.
Topics: Adolescent; Amnesia; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Antiemetics; An | 2012 |
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma | 2013 |
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma | 2013 |
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma | 2013 |
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma | 2013 |
The dawning of a new sedative: propofol in gastrointestinal endoscopy.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Health Care Costs; Humans; Hypnotics and Sedatives; | 2004 |
Management of sedation in mechanically ventilated patients.
Topics: Algorithms; Anxiety; Benzodiazepines; Humans; Hypnotics and Sedatives; Intensive Care Units; Monitor | 2004 |
[Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides].
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Emulsions; Female; Humans; Incidence; Lidocaine; Male; | 2004 |
[Pain on injection with propofol].
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Humans; Pain; Propofol | 2005 |
Bispectral index as a guide for titration of propofol during procedural sedation among children.
Topics: Adolescent; Adult; Algorithms; Anxiety; Catheterization; Child; Child, Preschool; Consciousness; Dev | 2005 |
Metabolic and endocrine effects of sedative agents.
Topics: Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Benzodiazepines; Catecholamines; Combined | 2005 |
A review of the use of propofol for procedural sedation in the emergency department.
Topics: Emergency Service, Hospital; Emergency Treatment; Evidence-Based Medicine; Humans; Hypnotics and Sed | 2006 |
Sedation in the mechanically ventilated patient.
Topics: Analgesics, Opioid; Benzodiazepines; Butyrophenones; Conscious Sedation; Drug Therapy, Combination; | 2006 |
Low-dose ketamine in addition to propofol for procedural sedation and analgesia in the emergency department.
Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Drug Therapy, Combination; Emergency Serv | 2007 |
Combination ketamine and propofol for procedural sedation and analgesia.
Topics: Analgesics; Anesthetics, Dissociative; Conscious Sedation; Controlled Clinical Trials as Topic; Drug | 2007 |
Propofol for sedation in the intensive care unit: essentials for the clinician.
Topics: Adult; Aged; Apnea; Bradycardia; Critical Care; Drug Administration Schedule; Half-Life; Humans; Hyp | 1997 |
The neurochemistry of central pain: evidence from clinical studies, hypothesis and therapeutic implications.
Topics: Anesthetics, Intravenous; Baclofen; Cerebral Cortex; GABA Agonists; gamma-Aminobutyric Acid; Glutami | 1998 |
Prolonged cutaneous sequelae after intra-arterial injection of propofol.
Topics: Adolescent; Anesthetics, Intravenous; Catheterization, Peripheral; Edema; Follow-Up Studies; Forearm | 1998 |
[Acute pain, analgesia, and sedation in children (IIIb): pharmacokinetics and pharmacodynamics of sedatives].
Topics: Acute Disease; Analgesia; Benzodiazepines; Child; Conscious Sedation; Humans; Hypnotics and Sedative | 1998 |
Pain on injection of propofol.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Chemistry, Pharmaceutical; Humans; Injections, Intrave | 1998 |
Comparing drugs for short-term sedation.
Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam; | 1994 |
Prevention of pain on injection with propofol: a quantitative systematic review.
Topics: Adult; Analgesics, Opioid; Humans; Injections; Lidocaine; Pain; Propofol; Randomized Controlled Tria | 2000 |
Pain management in the critically ill child.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Child; Child, Preschool; Critical Illness; Fentan | 2001 |
382 trials available for propofol and Pain
| Article | Year |
|---|---|
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives; | 2022 |
Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial.
Topics: Abortion, Induced; Adult; Anesthetics, Intravenous; Benzodiazepines; Dilatation and Curettage; Doubl | 2021 |
The Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial.
Topics: Aged; Benzodiazepines; Colonoscopy; Dose-Response Relationship, Drug; Etomidate; Female; Humans; Mal | 2021 |
The effects of target-controlled infusion of lidocaine undergoing vocal cord polypectomy: A randomized controlled trial (CONSORT compliant).
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Cough; Dose-Response Relationship, Drug; | 2022 |
Efficacy and Safety of HSK3486 for Anesthesia/Sedation in Patients Undergoing Fiberoptic Bronchoscopy: A Multicenter, Double-Blind, Propofol-Controlled, Randomized, Phase 3 Study.
Topics: Anesthesia; Bronchoscopy; Double-Blind Method; Humans; Hypnotics and Sedatives; Pain; Propofol | 2022 |
Efficacy and Safety of HSK3486 for Anesthesia/Sedation in Patients Undergoing Fiberoptic Bronchoscopy: A Multicenter, Double-Blind, Propofol-Controlled, Randomized, Phase 3 Study.
Topics: Anesthesia; Bronchoscopy; Double-Blind Method; Humans; Hypnotics and Sedatives; Pain; Propofol | 2022 |
Efficacy and Safety of HSK3486 for Anesthesia/Sedation in Patients Undergoing Fiberoptic Bronchoscopy: A Multicenter, Double-Blind, Propofol-Controlled, Randomized, Phase 3 Study.
Topics: Anesthesia; Bronchoscopy; Double-Blind Method; Humans; Hypnotics and Sedatives; Pain; Propofol | 2022 |
Efficacy and Safety of HSK3486 for Anesthesia/Sedation in Patients Undergoing Fiberoptic Bronchoscopy: A Multicenter, Double-Blind, Propofol-Controlled, Randomized, Phase 3 Study.
Topics: Anesthesia; Bronchoscopy; Double-Blind Method; Humans; Hypnotics and Sedatives; Pain; Propofol | 2022 |
Effect of intravenous lidocaine on propofol consumption in elderly patients undergoing colonoscopy: a double-blinded, randomized, controlled trial.
Topics: Aged; Anesthetics, Intravenous; Colonoscopy; Double-Blind Method; Humans; Lidocaine; Pain; Propofol; | 2022 |
A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Humans; | 2022 |
Comparison of the efficacy and safety of sedation protocols with the use of dexmedetomidine-remifentanil and propofol-remifentanil during percutaneous closure of atrial septal defects: a randomized clinical trial.
Topics: Clinical Protocols; Dexmedetomidine; Drug Combinations; Heart Septal Defects, Atrial; Humans; Hyperc | 2022 |
Remimazolam tosilate compared with propofol for gastrointestinal endoscopy in elderly patients: a prospective, randomized and controlled study.
Topics: Aged; Benzodiazepines; Endoscopy, Gastrointestinal; Humans; Hypnotics and Sedatives; Pain; Propofol; | 2022 |
Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial.
Topics: Adult; Benzodiazepines; Bradycardia; Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Mida | 2022 |
Comparison and Clinical Value of Ciprofol and Propofol in Intraoperative Adverse Reactions, Operation, Resuscitation, and Satisfaction of Patients under Painless Gastroenteroscopy Anesthesia.
Topics: Anesthesia; Anesthetics, Intravenous; Humans; Pain; Patient Satisfaction; Personal Satisfaction; Pro | 2022 |
Pretreatment with Low-Dose Esketamine for Reduction of Propofol Injection Pain: A Randomized Controlled Trial.
Topics: Anesthetics, Intravenous; Double-Blind Method; Humans; Ketamine; Lidocaine; Pain; Propofol | 2022 |
Comparison of Propofol-Fentanyl with Midazolam-Ketamine Combination in Pediatric Patients Undergoing Kidney Biopsy.
Topics: Analgesics; Biopsy; Child; Fentanyl; Humans; Ketamine; Kidney; Midazolam; Pain; Propofol | 2022 |
An Investigation Into Quality of Recovery After General Anesthesia With Isoflurane and Propofol in Patients Undergoing Abdominal Hysterectomy.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous; Female; Humans; Hysterect | 2022 |
Effects of Ultrasound-Guided Stellate Ganglion Block on Postoperative Quality of Recovery in Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Clinical Trial.
Topics: Breast Neoplasms; Female; Humans; Mastectomy; Pain; Propofol; Stellate Ganglion; Ultrasonography, In | 2022 |
A comparison of opioid-containing anesthesia versus opioid-free anesthesia using the Cortínez-Sepúlveda model on differential cytokine responses in obese patients undergoing gastric bypass surgery: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia; Cross-Sectional Studies; Cytokines; Female; Fentanyl; Gastric | 2022 |
Can intravenous lidocaine definitely attenuate propofol requirement and improve outcomes among colonoscopic patients under intravenous sedation?: A double-blinded, randomized controlled trial.
Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Colonoscopy; Double-Blind Method; Humans; | 2022 |
Total Intravenous Anesthesia Versus Inhaled Sevoflurane in Obstructive Sleep Apnea Surgery: A Randomized Controlled Trial.
Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intraveno | 2023 |
Deep breathing alleviates propofol-induced pain: a prospective, randomized, single-blind study.
Topics: Anesthetics, Intravenous; Double-Blind Method; Humans; Injections, Intravenous; Pain; Propofol; Pros | 2023 |
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus | 2022 |
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus | 2022 |
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus | 2022 |
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus | 2022 |
Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial.
Topics: Adolescent; Adult; Aged; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Dexmed | 2022 |
Safety and efficacy of etomidate in combination with oxycodone in painless gastroscopic procedures in the elderly: A prospective randomized controlled trial study.
Topics: Aged; Anesthetics, Intravenous; Etomidate; Gastroscopy; Humans; Nausea; Oxycodone; Pain; Propofol; P | 2023 |
Paralysis Versus Non-Paralysis Anesthesia for Operative Laryngoscopy: A Randomized Controlled Trial.
Topics: Androstanols; Anesthesia, General; Anesthetics, Intravenous; Female; Humans; Laryngoscopy; Male; Neu | 2023 |
Comparison of Remimazolam Tosilate and Etomidate on Hemodynamics in Cardiac Surgery: A Randomised Controlled Trial.
Topics: Anesthetics, Intravenous; Cardiac Surgical Procedures; Etomidate; Hemodynamics; Humans; Myoclonus; P | 2023 |
Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial.
Topics: Ambulatory Surgical Procedures; Flumazenil; Humans; Hypotension; Pain; Propofol; Prospective Studies | 2023 |
Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Humans; Hypnotics and Sedatives; Intensive Care Units; M | 2023 |
Prevention of pain on injection of propofol using ice gel pack versus pre-treatment with lignocaine: a randomized controlled trial.
Topics: Double-Blind Method; Humans; Ice; Injections, Intravenous; Lidocaine; Pain; Propofol | 2023 |
Efficacy and Safety of Ciprofol for Sedation/Anesthesia in Patients Undergoing Hysteroscopy: A Randomized, Parallel-Group, Controlled Trial.
Topics: Anesthesia; Anesthetics, Intravenous; Female; Humans; Hypnotics and Sedatives; Hysteroscopy; Nausea; | 2023 |
Remimazolam versus propofol in combination with esketamine for surgical abortion: A double-blind randomized controlled trial.
Topics: Anesthetics, General; Benzodiazepines; Exanthema; Female; Humans; Pain; Pregnancy; Propofol | 2023 |
The effect of opioid-free anaesthesia on the quality of recovery after endoscopic sinus surgery: A multicentre randomised controlled trial.
Topics: Analgesics, Opioid; Anesthesia; Humans; Pain; Pain, Postoperative; Postoperative Nausea and Vomiting | 2023 |
Effects of intravenous administration of magnesium sulfate in propofol-based sedation for ERCP in elderly patients: a randomized, double-blind, placebo-controlled study.
Topics: Administration, Intravenous; Aged; Cholangiopancreatography, Endoscopic Retrograde; Double-Blind Met | 2023 |
Effect of ciprofol on swallowing function in patients undergoing painless gastrointestinal endoscopy.
Topics: Deglutition; Endoscopy, Gastrointestinal; Gastroscopy; Humans; Pain; Propofol | 2023 |
Different sedation profiles with ciprofol compared to propofol represented by objective sedation level assessments by BIS and its acute hemodynamic impact in 3 escalated doses of ciprofol and propofol in healthy subjects: a single-center, open-label, rand
Topics: Cross-Over Studies; Healthy Volunteers; Hemodynamics; Humans; Male; Pain; Propofol | 2023 |
Remimazolam vs Etomidate: Haemodynamic Effects in Hypertensive Elderly Patients Undergoing Non-Cardiac Surgery.
Topics: Aged; Anesthesia, General; Etomidate; Hemodynamics; Humans; Hypertension; Myoclonus; Pain; Propofol; | 2023 |
Sucking lollipop after awakening from sevoflurane anesthesia reduces the degree of emergence agitation in children undergoing ambulatory surgery: A prospective randomized controlled trial.
Topics: Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhala | 2023 |
Efficacy of pretreatment with remimazolam on prevention of propofol-induced injection pain in patients undergoing gastroscopy.
Topics: Adolescent; Adult; Aged; Benzodiazepines; Gastroscopy; Humans; Middle Aged; Pain; Propofol; Saline S | 2023 |
Propofol for migraine in the emergency department: A pilot randomised controlled trial.
Topics: Adult; Conscious Sedation; Emergency Service, Hospital; Humans; Migraine Disorders; Pain; Pilot Proj | 2020 |
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Body Weight; Double-Blind Method; Humans; Lidocaine; P | 2021 |
Pain Intensity at Injection Site during Esophagogastroduodenoscopy Using Long- and Medium-Chain versus Long-Chain Triglyceride Propofol: A Randomized Controlled Double-Blind Study.
Topics: Anesthetics, Intravenous; Double-Blind Method; Endoscopy, Digestive System; Humans; Pain; Propofol; | 2021 |
The Effect of Vibration on Pain During Intravenous Injection of Propofol: A Randomized Controlled Trial.
Topics: Anesthetics, Intravenous; Humans; Injections, Intravenous; Pain; Propofol; Prospective Studies; Sing | 2021 |
Intravenous Lidocaine Alleviates the Pain of Propofol Injection by Local Anesthetic and Central Analgesic Effects.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Central Nervous System; Double-Blind Method; Fe | 2018 |
Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Analgesics, Opioid; Anxiety; Double-Blind Method; E | 2018 |
Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Analgesics, Opioid; Anxiety; Double-Blind Method; E | 2018 |
Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Analgesics, Opioid; Anxiety; Double-Blind Method; E | 2018 |
Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Analgesics, Opioid; Anxiety; Double-Blind Method; E | 2018 |
Preventive effect of a vapocoolant spray on propofol-induced pain: a prospective, double-blind, randomized study.
Topics: Adult; Analgesia; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle A | 2017 |
Effect of propofol combined with opioids on cough reflex suppression in gastroscopy: study protocol for a double-blind randomized controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Antitussive Agents; Bridged Bicyclo Compounds, Heterocy | 2017 |
Effects of sedation on subjective perception of pain intensity and autonomic nervous responses to pain: A preliminary study.
Topics: Adult; Anesthetics, Intravenous; Autonomic Nervous System; Conscious Sedation; Humans; Hypnotics and | 2017 |
Nociceptive stimulation during Macintosh direct laryngoscopy compared with McGrath Mac videolaryngoscopy: A randomized trial using indirect evaluation using an automated administration of propofol and remifentanil.
Topics: Adult; Aged; Anesthetics, Intravenous; Female; Humans; Intubation, Intratracheal; Laryngoscopy; Male | 2017 |
Effect of dexmedetomidine for attenuation of propofol injection pain in electroconvulsive therapy: a randomized controlled study.
Topics: Adolescent; Adult; Analgesics; Dexmedetomidine; Double-Blind Method; Electroconvulsive Therapy; Fema | 2018 |
Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study.
Topics: Adolescent; Adult; Aged; Butylscopolammonium Bromide; Double-Blind Method; Female; Humans; Male; Mid | 2018 |
Evaluation of efficacy of Valsalva maneuver for attenuating propofol injection pain: a prospective, randomized, single blind, placebo controlled study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Male; Middle A | 2018 |
Factors Associated With Adenoma Detection in Propofol-sedated Patients.
Topics: Adenoma; Adult; Aged; Colonoscopy; Colorectal Neoplasms; Female; Humans; Hypnotics and Sedatives; In | 2019 |
The use of remifentanil in critically ill patients undergoing percutaneous dilatational tracheostomy: A prospective randomized-controlled trial.
Topics: Adult; Critical Illness; Female; Hemodynamics; Humans; Male; Pain; Propofol; Prospective Studies; Re | 2019 |
Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Doub | 2019 |
Analgesia-first sedation in critically ill adults: A U.S. pilot, randomized controlled trial.
Topics: Aged; Analgesia; Analgesics, Opioid; Anesthesia; California; Clinical Protocols; Critical Illness; D | 2019 |
Propofol sedation for colonoscopy with a new ultrathin or a standard endoscope: a prospective randomized controlled study.
Topics: Adenoma; Aged; Cecum; Colonic Neoplasms; Colonoscopes; Colonoscopy; Conscious Sedation; Female; Huma | 2013 |
Modeling the influence of the A118G polymorphism in the OPRM1 gene and of noxious stimulation on the synergistic relation between propofol and remifentanil: sedation and analgesia in endoscopic procedures.
Topics: Acoustic Stimulation; Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Combined; Anesthetics, | 2013 |
Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Anesthetics, Local; Elective Surgical Procedures; Femal | 2013 |
Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines.
Topics: Adolescent; Adult; Alfentanil; Analgesics, Opioid; Anesthetics, Combined; Biomarkers; Catecholamines | 2013 |
Effect of alkalinisation of lignocaine for propofol injection pain: a prospective, randomised, double-blind study.
Topics: Adolescent; Adult; Alkalies; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Fema | 2013 |
An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Double | 2013 |
Effect of nitrous oxide inhalation on pain after propofol and rocuronium injection.
Topics: Administration, Inhalation; Adult; Androstanols; Double-Blind Method; Female; Humans; Injections; Ma | 2013 |
Prediction of effect-site concentration of sufentanil by dose-response target controlled infusion of sufentanil and propofol for analgesic and sedation maintenance in burn dressing changes.
Topics: Adult; Analgesics, Opioid; Bandages; Burns; Dose-Response Relationship, Drug; Feasibility Studies; F | 2014 |
Reducing the pain of microemulsion propofol injections: a double-blind, randomized study of three methods of tourniquet and lidocaine.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; | 2013 |
Cisatracurium pretreatment with tourniquet reduces propofol injection pain: a double-blind randomized controlled trial.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Atracuri | 2014 |
Intravenous lidocaine pretreatment with venous occlusion for reducing microemulsion propofol induced pain: comparison of three doses of lidocaine.
Topics: Administration, Intravenous; Adult; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Metho | 2014 |
Influence of polyvinyl chloride infusion extension tube on propofol injection pain: a randomised controlled study.
Topics: Adult; Aged; Diethylhexyl Phthalate; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Pain | 2014 |
[Effect of concentration on counting numbers on pain induced by injection of propofol].
Topics: Adult; Age Factors; Attention; Female; Humans; Injections, Intravenous; Logistic Models; Male; Middl | 2014 |
Preemptive dexmedetomidine to prevent propofol injection pain in children.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Dexmedetomidine; Double-Blind | 2015 |
Total intravenous anaesthesia with high-dose remifentanil does not aggravate postoperative nausea and vomiting and pain, compared with low-dose remifentanil: a double-blind and randomized trial.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Breast Neoplasms; Dose-Response Relationsh | 2014 |
Magnesium sulfate with lidocaine for preventing propofol injection pain: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; D | 2015 |
[Effectiveness of local cooling and lidocaine administration for prevention of pain upon injection of propofol].
Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Cryotherapy; Female; | 2014 |
Dexmedetomidine reduces pain associated with rocuronium injection without causing a decrease in BIS values: a dose-response study.
Topics: Adult; Analgesics, Non-Narcotic; Androstanols; Anesthesia, General; Dexmedetomidine; Dose-Response R | 2014 |
Topical analgesia treats pain and decreases propofol use during lumbar punctures in a randomized pediatric leukemia trial.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Child; Child, Preschool; Cross-Over | 2015 |
Comparing the pain of propofol via different combinations of fentanyl, sufentanil or remifentanil in gastrointestinal endoscopy.
Topics: Adult; Aged; Analgesics, Opioid; Drug Combinations; Endoscopy, Gastrointestinal; Female; Fentanyl; H | 2014 |
Dexmedetomidine pretreatment alleviates propofol injection pain.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Dexmedetomidine; Double-Blind | 2014 |
A prospective, randomized controlled trial of conscious sedation using propofol combined with inhaled nitrous oxide for dental treatment.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Inh | 2015 |
Propofol-ketamine or propofol-remifentanil for deep sedation and analgesia in pediatric patients undergoing burn dressing changes: a randomized clinical trial.
Topics: Analgesia; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages | 2015 |
[Sedative effects of dexmedetomidine in post-operative elder patients on mechanical ventilation].
Topics: Aged; Analgesics; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Ca | 2014 |
Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children--blind randomised trial.
Topics: Adolescent; Alfentanil; Analgesics, Opioid; Child; Conscious Sedation; Double-Blind Method; Drug The | 2015 |
Effects of Different Anesthetics on Pain Processing in an Experimental Human Pain Model.
Topics: Adult; Analgesics, Opioid; Anesthetics; Female; Humans; Hyperalgesia; Ketamine; Male; Pain; Pain Mea | 2016 |
Feasibility of monitoring stress using skin conduction measurements during intubation of newborns.
Topics: Anesthetics, Combined; Anesthetics, Intravenous; Deep Sedation; Feasibility Studies; Galvanic Skin R | 2016 |
Effects of pretreatment with esmolol and lidocaine on injection pain and rocuronium-induced withdrawal response.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Androstanols; Anesthesia, General; Anesthetics, Intra | 2015 |
Magnesium Sulfate Plus Lidocaine Reduces Propofol Injection Pain: A Double-blind, Randomized Study.
Topics: Adult; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Drug Therapy, | 2016 |
A randomised controlled trial: can acupuncture reduce drug requirement during analgosedation with propofol and alfentanil for colonoscopy? A study protocol.
Topics: Acupuncture Therapy; Adult; Alfentanil; Colonoscopy; Conscious Sedation; Dose-Response Relationship, | 2015 |
Comparison of Propofol, Propofol-Remifentanil, and Propofol-Fentanyl Administrations with Each Other Used for the Sedation of Patients to Undergo ERCP.
Topics: Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Dose- | 2015 |
[Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit].
Topics: Analgesics; Circadian Rhythm; Critical Care; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics | 2016 |
Efficacy of different fluids preload on propofol injection pain: A randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Aged; Electrolytes; Female; Humans; Injections, Intravenous; Male; Middle Aged; P | 2016 |
Non-anesthesiologist administration of propofol sedation for colonoscopy is safe in low risk patients: results of a noninferiority randomized controlled trial.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesiology; Colonoscopy; Deep Sedation; Female; Humans; | 2016 |
The median effective concentration (EC50) of propofol with different doses of fentanyl during colonoscopy in elderly patients.
Topics: Aged; Aged, 80 and over; Anesthetics, Intravenous; Colonoscopy; Dose-Response Relationship, Drug; Do | 2016 |
Two Different Concentrations of Ketofol for Procedural Sedation and Analgesia in Closed Reduction of Nasal Fracture.
Topics: Adolescent; Adult; Analgesia; Anesthetics, Intravenous; Child; Conscious Sedation; Double-Blind Meth | 2016 |
Comparison of the effects of lidocaine pre-administration and local warming of the intravenous access site on propofol injection pain: Randomized, double-blind controlled trial.
Topics: Double-Blind Method; Fever; Humans; Lidocaine; Pain; Propofol; Prospective Studies | 2016 |
Entropy vs standard clinical monitoring using total intravenous anesthesia during transvaginal oocyte retrieval in patients for in vitro fertilization.
Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Fentanyl; Fer | 2016 |
Impact of time interval between remifentanil and propofol on propofol injection pain.
Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Intravenous; Female; Humans; Injections | 2016 |
Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection: A double-blind, randomized clinical consort study.
Topics: Adult; Analgesics; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intra | 2016 |
Efficacy of midazolam- versus propofol-based sedations by non-anesthesiologists during therapeutic endoscopic retrograde cholangiopancreatography in patients aged over 80 years.
Topics: Aged, 80 and over; Biliary Tract Diseases; Cholangiopancreatography, Endoscopic Retrograde; Consciou | 2017 |
Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Double- | 2017 |
An assessment of computer-assisted personalized sedation: a sedation delivery system to administer propofol for gastrointestinal endoscopy.
Topics: Adult; Aged; Anesthesia Recovery Period; Belgium; Colonoscopy; Conscious Sedation; Dose-Response Rel | 2008 |
Nurse-administered propofol sedation compared with midazolam and meperidine for EUS: a prospective, randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Anesthesia Recovery Period; Anesthetics, Intravenou | 2008 |
Avoiding propofol injection pain in children: a prospective, randomized, double-blinded, placebo-controlled study.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Chemistry, Pharmaceutical; Child; Child, Preschool; Do | 2008 |
Does addition of lidocaine to medium- and long-chain triglyceride propofol emulsions significantly reduce pain on injection?
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Emulsions; Female; Humans; | 2008 |
Duration of venous occlusion with lidocaine for preventing propofol induced pain.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Elective Surgical Procedur | 2008 |
Efficacy of combination intravenous lidocaine and dexamethasone on propofol injection pain: a randomized, double-blind, prospective study in adult Korean surgical patients.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Dexamethasone; Double-Blind Method; Drug | 2008 |
Pediatric oncology sedation trial (POST): A double-blind randomized study.
Topics: Adolescent; Antiemetics; Antineoplastic Agents; Biopsy, Needle; Bone Marrow Examination; Child; Chil | 2008 |
Low fresh gas flow balanced anesthesia versus target controlled intravenous infusion anesthesia in laparoscopic cholecystectomy: a cost-minimization analysis.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Chol | 2008 |
[Efficacy of a low dose of ketamine in reduction of propofol-injection-related pain].
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Female; Gynecologic Su | 2009 |
Pain on injection with microemulsion propofol.
Topics: Adult; Aged; Aged, 80 and over; Bradykinin; Chromatography, High Pressure Liquid; Emulsions; Female; | 2009 |
Admixture of ephedrine to offset side effects of propofol: a randomized, controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anesthetics, Local; Blood Pres | 2009 |
Prevention of propofol pain: a comparative study.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; | 2009 |
Pretreatment with flurbiprofen axetil, flurbiprofen axetil preceded by venous occlusion, and a mixture of flurbiprofen axetil and propofol in reducing pain on injection of propofol in adult Japanese surgical patients: a prospective, randomized, double-bli
Topics: Adult; Aged; Anesthetics, Intravenous; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Flurb | 2009 |
Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone.
Topics: Alfentanil; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschoo | 2009 |
[Effects of the injection method of lidocaine on preventing injection pain during anesthesia induction by target controlled infusion with propofol].
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Female; Humans; Infusions, Intravenous; I | 2009 |
[Effects of granisetron/lidocaine combination on propofol injection-induced pain: a double-blind randomized clinical trial].
Topics: Adult; Double-Blind Method; Drug Therapy, Combination; Female; Granisetron; Humans; Injections, Intr | 2009 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
Topics: Acetaminophen; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injecti | 2010 |
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha | 2010 |
Fentanyl pre-treatment alleviates pain during injection of propofol-lipuro premixed with lignocaine.
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Drug Administr | 2008 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
Randomized clinical trial of propofol with and without alfentanil for deep procedural sedation in the emergency department.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Deep Sedation; Drug Combinations; Emergency Medical Ser | 2009 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
A comparison of pretreatment with fentanyl and lidocaine preceded by venous occlusion for reducing pain on injection of propofol: a prospective, randomized, double-blind, placebo-controlled study in adult Japanese surgical patients.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; | 2009 |
The effect of single-dose propofol injection on pain and quality of life in chronic daily headache: a randomized, double-blind, controlled trial.
Topics: Adult; Analgesics; Disability Evaluation; Double-Blind Method; Drug Administration Schedule; Female; | 2009 |
Prevention of propofol injection pain with small-dose ketamine.
Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Ketamine; Male; Pain; Propofol | 2009 |
Pain on injection from propofol may be avoided by changing its formulation.
Topics: Anesthetics; Anesthetics, Local; Chemistry, Pharmaceutical; Double-Blind Method; Fourier Analysis; H | 2010 |
Ketamine eliminates propofol pain but does not affect hemodynamics during induction with double-lumen tubes.
Topics: Aged; Analgesics; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Female; Hemodynamics; | 2010 |
Effect of menstrual cycle on the injection pain due to propofol.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Follicular Phase; Humans; | 2010 |
Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia.
Topics: Adult; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Chemistry, Pharmaceuti | 2010 |
Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship | 2010 |
The effect of a 3 : 1 volume mixture of propofol 1% and thiopental 2.5% in reducing the pain on injection of propofol in children.
Topics: Adolescent; Age Factors; Algorithms; Anesthetics, Combined; Anesthetics, Intravenous; Blood Pressure | 2010 |
Does the newer preparation of propofol, an emulsion of medium/long chain triglycerides cause less injection pain in children when premixed with lignocaine?
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Presc | 2010 |
A randomized controlled trial comparing patient-controlled and physician-controlled sedation in the emergency department.
Topics: Adult; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Conscious Sedation; Emergency Servic | 2010 |
Comparison of procedural sequences in same-day bidirectional endoscopy without benzodiazepine and propofol sedation: starting at the bottom or the top.
Topics: Adult; Aged; Anemia; Benzodiazepines; Colonoscopy; Conscious Sedation; Digestive System Diseases; En | 2010 |
Comparison of procedural sequences in same-day bidirectional endoscopy without benzodiazepine and propofol sedation: starting at the bottom or the top.
Topics: Adult; Aged; Anemia; Benzodiazepines; Colonoscopy; Conscious Sedation; Digestive System Diseases; En | 2010 |
Comparison of procedural sequences in same-day bidirectional endoscopy without benzodiazepine and propofol sedation: starting at the bottom or the top.
Topics: Adult; Aged; Anemia; Benzodiazepines; Colonoscopy; Conscious Sedation; Digestive System Diseases; En | 2010 |
Comparison of procedural sequences in same-day bidirectional endoscopy without benzodiazepine and propofol sedation: starting at the bottom or the top.
Topics: Adult; Aged; Anemia; Benzodiazepines; Colonoscopy; Conscious Sedation; Digestive System Diseases; En | 2010 |
Comparison of paravertebral block versus fast-track general anesthesia via laryngeal mask airway in outpatient inguinal herniorrhaphy.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, General; Anesth | 2010 |
Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol.
Topics: Acoustic Stimulation; Adult; Analysis of Variance; Brain; Brain Mapping; Consciousness; Female; Huma | 2010 |
Analgesic and antihyperalgesic properties of propofol in a human pain model.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fat Emulsions, Int | 2010 |
Propofol injection pain: is it still an issue? The effect of premedication.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Double-Blind Method; Humans; Middle Aged; Pain; P | 2010 |
Comparison of the surgical Pleth Index™ with haemodynamic variables to assess nociception-anti-nociception balance during general anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Femal | 2011 |
Comparison of the surgical Pleth Index™ with haemodynamic variables to assess nociception-anti-nociception balance during general anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Femal | 2011 |
Comparison of the surgical Pleth Index™ with haemodynamic variables to assess nociception-anti-nociception balance during general anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Femal | 2011 |
Comparison of the surgical Pleth Index™ with haemodynamic variables to assess nociception-anti-nociception balance during general anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Femal | 2011 |
Does lidocaine more effectively prevent pain upon induction with propofol or etomidate when given preemptively than when mixed with the drug?
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Drug Administration | 2010 |
Optimal target concentration of remifentanil during cataract surgery with monitored anesthesia care.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Cataract Extraction; Dose-Resp | 2010 |
Propofol versus propofol/ketamine for brief painful procedures in the emergency department: clinical and bispectral index scale comparison.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, In | 2010 |
A subhypnotic dose of ketamine reduces pain associated with injection of propofol and rocuronium.
Topics: Adolescent; Adult; Analgesics; Androstanols; Anesthetics, Intravenous; Dose-Response Relationship, D | 2011 |
Effect of intravenous propofol and remifentanil on heart rate, blood pressure and nociceptive response in acepromazine premedicated dogs.
Topics: Acepromazine; Anesthesia, General; Animals; Blood Pressure; Dogs; Dopamine Antagonists; Female; Hear | 2011 |
[Application of subclinical doses of pentazocine and propofol in painless vaginal egg retrieval].
Topics: Adjuvants, Anesthesia; Adult; Anesthetics, Intravenous; Female; Fertilization in Vitro; Humans; Intr | 2011 |
Efficacy of the lidocaine/flurbiprofen axetil combination for reducing pain during the injection of propofol.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Lo | 2011 |
A randomized controlled trial of endoscopist vs. anaesthetist-administered sedation for colonoscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Colonoscopy; Conscious Sedatio | 2011 |
Pain on injection of propofol: a comparison of methylene blue and lidocaine.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Enzyme Inhibitors; Female; | 2011 |
Remifentanil for the insertion and removal of long-term central venous access during monitored anesthesia care.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Catheterization, Central Venous; Catheter | 2011 |
The effect of combined ephedrine and lidocaine pretreatment on pain and hemodynamic changes due to propofol injection.
Topics: Adult; Anesthetics, Intravenous; Ephedrine; Female; Hemodynamics; Humans; Injections; Lidocaine; Mal | 2011 |
Sevoflurane to alleviate pain on propofol injection.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Fentanyl; Humans; Injections, Intr | 2011 |
Propofol in a modified cyclodextrin formulation: first human study of dose-response with emphasis on injection pain.
Topics: Adolescent; Adult; Anesthetics, Intravenous; beta-Cyclodextrins; Chemistry, Pharmaceutical; Consciou | 2011 |
Reduced pain on injection with a 0.5% propofol emulsion during induction of anesthesia.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Fat Emulsions, Intravenous; Humans; Injections, I | 2012 |
Rapid injection of propofol reduces vascular pain and facilitates Laryngeal Mask Airway insertion.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Female; Hospitals, University; Humans; La | 2011 |
Moderate sedation for elective upper endoscopy with balanced propofol versus fentanyl and midazolam alone: a randomized clinical trial.
Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Deep Sedation; Endoscopy, Digesti | 2012 |
Incidence of propofol injection pain and effect of lidocaine pretreatment during upper gastrointestinal endoscopy.
Topics: Aged; Anesthetics, Intravenous; Conscious Sedation; Endoscopy, Gastrointestinal; Female; Humans; Inc | 2012 |
Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery.
Topics: Adult; Aged; Aged, 80 and over; Atropine; Blood Pressure; Cervical Vertebrae; Dexmedetomidine; Dopam | 2012 |
Reduction of microemulsion propofol-induced injection pain via target-controlled remifentanil infusion.
Topics: Adult; Anesthetics, Intravenous; Demography; Emulsions; Female; Humans; Infusions, Intravenous; Inje | 2011 |
Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs.
Topics: Anesthetics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; Cross-Over Studies; Dog Diseases; | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypno | 2012 |
Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine.
Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Elective Surgical Procedures; Female; Humans; | 2012 |
Ondansetron pretreatment reduces pain on injection of propofol.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; | 2012 |
Prevention of propofol-induced pain in children: pretreatment with small doses of ketamine.
Topics: Analgesics; Anesthetics, Intravenous; Child; Child, Preschool; Dose-Response Relationship, Drug; Dou | 2012 |
Prospective randomized crossover evaluation of three anesthetic regimens for painful procedures in children with cancer.
Topics: Adolescent; Anesthesia; Anesthetics, Intravenous; Bone Marrow Examination; Child; Child, Preschool; | 2013 |
Alfentanil and patient-controlled propofol sedation - facilitate gynaecological outpatient surgery with increased risk of respiratory events.
Topics: Adult; Aged; Aged, 80 and over; Alfentanil; Ambulatory Surgical Procedures; Anesthetics, Intravenous | 2012 |
Prevention of propofol injection pain in children: a comparison of pretreatment with tramadol and propofol-lidocaine mixture.
Topics: Anesthetics, Local; Child; Female; Humans; Injections, Intravenous; Lidocaine; Male; Pain; Propofol; | 2012 |
[Comparison between insufflation with air or carbon dioxide during the colonoscopy in sedated patients with propofol].
Topics: Adult; Aged; Aged, 80 and over; Air; Carbon Dioxide; Colonoscopy; Conscious Sedation; Female; Humans | 2012 |
Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial.
Topics: Adult; Anesthetics, Intravenous; Bradycardia; Double-Blind Method; Ephedrine; Female; Humans; Hypote | 2012 |
A prospective, randomized, double-blind study to compare the efficacy of lidocaine + metoclopramide and lidocaine + ketamine combinations in preventing pain on propofol injection.
Topics: Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Loca | 2013 |
The effects of remifentanil, lidocaine, metoclopramide, or ketamine pretreatment on propofol injection pain.
Topics: Adult; Aged; Analgesics; Double-Blind Method; Female; Humans; Injections, Intravenous; Ketamine; Lid | 2012 |
Dexmedetomidine impairs success of patient-controlled sedation in alcoholics during ERCP: a randomized, double-blind, placebo-controlled study.
Topics: Alcoholism; Alfentanil; Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retrograde; C | 2013 |
Epidural anaesthesia with goal-directed administration of ropivacaine improves haemodynamic stability when combined with general anaesthesia in elderly patients undergoing major abdominal surgery.
Topics: Abdomen; Age Factors; Aged; Amides; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local; B | 2013 |
A prospective randomized trial comparing patient-controlled sedation using propofol and alfentanil and physician-administered sedation using diazepam and pethidine during transvaginal ultrasound-guided oocyte retrieval.
Topics: Adult; Alfentanil; Analgesia, Patient-Controlled; Analgesics, Opioid; Conscious Sedation; Diazepam; | 2002 |
Effect of pretreatment with ketorolac on propofol injection pain.
Topics: Adult; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal | 2002 |
Can neostigmine reduce propofol injection pain?
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Cholinesterase Inhibitors; Do | 2002 |
The use of magnesium sulfate to prevent pain on injection of propofol.
Topics: Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Inje | 2002 |
[Effects of concentration and dosage of lidocaine on preventing the pain on injection of propofol].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Injections, Intrav | 2002 |
Ephedrine reduces the pain from propofol injection.
Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Double-Blind Method; Ephedrine; Female; Heart Rate; | 2002 |
In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine.
Topics: Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind Method; Female; Humans; Injections, | 2002 |
An admixture of 3 mg x kg(-1) of propofol and 3 mg x kg(-1) of thiopentone reduces pain on injection in pediatric anesthesia.
Topics: Anesthetics, Intravenous; Child; Child, Preschool; Drug Combinations; Female; Humans; Infant; Inject | 2002 |
Pain and distress from bone marrow aspirations and lumbar punctures.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Biopsy, Needle; Bon | 2003 |
Propofol 1% versus propofol 2% in children undergoing minor ENT surgery.
Topics: Adenoidectomy; Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind Method; Humans; Otorh | 2003 |
Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Intravenous; A | 2003 |
Prevention of propofol-induced injection pain by remifentanil: a placebo-controlled comparison with lidocaine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetic | 2003 |
Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia.
Topics: Adult; Anesthetics, Intravenous; Creatine Kinase; Double-Blind Method; Fasciculation; Female; Gyneco | 2003 |
Low-rate repetitive TMS allays central pain.
Topics: Adult; Aged; Electric Stimulation Therapy; Female; Humans; Hypnotics and Sedatives; Magnetics; Male; | 2003 |
Pain on injection of propofol: comparison of metoprolol with lidocaine.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Hum | 2003 |
A 5-microm filter does not reduce propofol-induced pain.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Double-Blind Method; Drug Contamination; Female; | 2003 |
The effect of mixing lidocaine with propofol on the dose of propofol required for induction of anesthesia.
Topics: Adolescent; Adult; Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics | 2003 |
Patient-controlled sedation for colonoscopy: a randomized trial comparing patient-controlled administration of propofol and alfentanil with physician-administered midazolam and pethidine.
Topics: Adjuvants, Anesthesia; Adult; Aged; Aged, 80 and over; Alfentanil; Analgesia, Patient-Controlled; An | 2003 |
The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol.
Topics: Administration, Topical; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthetics, Combi | 2003 |
Patient-controlled sedation using propofol for dressing changes in burn patients: a dose-finding study.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anxiety; Bandages; Burns; Conscious Sedation; D | 2003 |
Early recovery after remifentanil-pronounced compared with propofol-pronounced total intravenous anaesthesia for short painful procedures.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intraveno | 2003 |
Incidence of pain after intravenous injection of a medium-/long-chain triglyceride emulsion of propofol. An observational study in 1375 patients.
Topics: Adult; Anesthetics, Intravenous; Catheterization; Emulsions; Excipients; Fatty Acids; Female; Humans | 2003 |
Pharmacological characteristics and side effects of a new galenic formulation of propofol without soyabean oil.
Topics: Adult; Anesthetics, Intravenous; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Do | 2003 |
Pretreatment with intravenous ketamine reduces propofol injection pain.
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Doubl | 2003 |
Propofol 2% in two different oil-in-water emulsions: a randomized, double-blind study.
Topics: Anesthetics, Intravenous; Double-Blind Method; Drug Delivery Systems; Electroencephalography; Emulsi | 2003 |
[Nicorandil reduces incidence and severity of pain on propofol injection].
Topics: Adult; Anesthetics, Intravenous; Humans; Infusions, Intravenous; Injections, Intravenous; Nicorandil | 2003 |
Dose-dependent effects of propofol on the central processing of thermal pain.
Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response R | 2004 |
[Propofol-LCT versus propofol-MCT/LCT with or without lidocaine - a comparison on pain on injection].
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; E | 2004 |
[Remifentanil is an effective alternative to propofol for patient-controlled analgesia during digestive endoscopic procedures].
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Endoscopy, | 2004 |
Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified.
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Elective Surgical Proce | 2004 |
Pretreatment with thiopental for prevention of pain associated with propofol injection.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine; | 2004 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Patient-controlled versus nurse-administered sedation with propofol during colonoscopy. A prospective randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Colonoscopy; Conscious Sedation; Fema | 2004 |
Remifentanil pretreatment for propofol injection pain in children.
Topics: Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Huma | 2004 |
Comparative benefit of preemptively applied thiopental for propofol injection pain: the advantage over lidocaine.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Body Weight; Dose-Response Relationship, | 2004 |
Pain during injection of propofol: the effect of prior administration of butorphanol.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Butorphanol; Cross-Over Stu | 2004 |
Propofol or propofol--alfentanil anesthesia for painful procedures in the pediatric oncology ward.
Topics: Adolescent; Alfentanil; Anesthetics, Intravenous; Anxiety; Biopsy, Needle; Bone Marrow Examination; | 2004 |
The effect of coinduction with midazolam on propofol injection pain.
Topics: Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Midazol | 2004 |
Propofol-induced injection pain: comparison of a modified propofol emulsion to standard propofol with premixed lidocaine.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Chem | 2004 |
Propofol and sevoflurane during epidural/general anesthesia: comparison of early recovery characteristics and pain relief.
Topics: Abdomen; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia Recovery Period; | 2004 |
Effect of metoclopramide on pain on injection of propofol.
Topics: Adult; Aged; Analysis of Variance; Anesthesia, General; Chi-Square Distribution; Dose-Response Relat | 2004 |
Pain during injection of propofol: the effect of prior administration of ephedrine.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Dose-Response Relationship, Drug; Double-Blind Method; D | 2004 |
Comparison of Propofol-Lipuro with propofol mixed with lidocaine 10 mg on propofol injection pain.
Topics: Adolescent; Adult; Aged; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Chemis | 2004 |
Pain on injection: a double-blind comparison of propofol with lidocaine pretreatment versus propofol formulated with long- and medium-chain triglycerides.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Anesthetics, Local; Chemistry, Pharmaceutical; Double-B | 2004 |
The effects of alfentanil or remifentanil pretreatment on propofol injection pain.
Topics: Adult; Alfentanil; Anesthetics, Intravenous; Double-Blind Method; Drug Therapy, Combination; Female; | 2004 |
[Incidence of pain upon injection of a new formula of propofol in a fat emulsion of medium- and long-chain triglycerides].
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Emulsions; Female; Humans; Incidence; Lidocaine; Male; | 2004 |
Effect of diclofenac pretreatment on pain during propofol injection.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Chi-Square Distribution; Diclofenac; Dose-Response Rela | 2004 |
The effect of propofol on thermal pain perception.
Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hot Temper | 2005 |
Preventing pain on injection of propofol: a comparison between lignocaine pre-treatment and lignocaine added to propofol.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; Humans; Injections, Intra | 2004 |
The relationship between bispectral index and targeted propofol concentration is biphasic in patients with major burns.
Topics: Adult; Algorithms; Anesthetics, Intravenous; Burns; Critical Care; Electroencephalography; Female; H | 2005 |
Less local pain on intravenous infusion of a new propofol emulsion.
Topics: Anesthetics, Intravenous; Cross-Over Studies; Double-Blind Method; Emulsions; Female; Humans; Infusi | 2005 |
Bacteriostatic saline containing benzyl alcohol decreases the pain associated with the injection of propofol.
Topics: Adult; Anesthetics, Local; Bacteria; Benzyl Alcohol; Double-Blind Method; Female; Humans; Injections | 2005 |
Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Double-Blind Met | 2005 |
Ketamine pretreatment with venous occlusion attenuates pain on injection with propofol.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Arm; Double-Blind Method; Female; Humans | 2005 |
A lidocaine/metoclopramide combination decreases pain on injection of propofol.
Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inj | 2005 |
A combination of lidocaine and nitrous oxide in oxygen is more effective in preventing pain on propofol injection than either treatment alone.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Double-Bli | 2005 |
Propofol injection pain in children: a prospective randomized double-blind trial of a new propofol formulation versus propofol with added lidocaine.
Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind M | 2005 |
The effects of intravenous lidocaine on pain during injection of medium- and long-chain triglyceride propofol emulsions.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Emulsions; Exc | 2005 |
Bispectral index as a guide for titration of propofol during procedural sedation among children.
Topics: Adolescent; Adult; Algorithms; Anxiety; Catheterization; Child; Child, Preschool; Consciousness; Dev | 2005 |
Effect of nitrous oxide in reducing pain of propofol injection in adult patients.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; F | 2005 |
Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients.
Topics: Adult; Aged; Anesthetics, Intravenous; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; | 2005 |
A comparison of pain on intravenous injection between two preparations of propofol.
Topics: Adult; Anesthetics, Intravenous; Chemistry, Pharmaceutical; Cross-Over Studies; Double-Blind Method; | 2005 |
Propofol versus midazolam/ketamine for procedural sedation in pediatric oncology.
Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Humans; Hypnotic | 2005 |
Pain on injection of lipid-free propofol and propofol emulsion containing medium-chain triglyceride: a comparative study.
Topics: Adult; Chemistry, Pharmaceutical; Emulsions; Humans; Incidence; Injections, Intravenous; Middle Aged | 2005 |
Reduction of pain on injection of propofol using meperidine and remifentanil.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Double- | 2005 |
Efficacy of dexamethasone pretreatment for alleviation of propofol injection pain.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Dexamethasone; Dose-Response Relationship, Drug; Double | 2005 |
How to decrease pain at rapid injection of propofol: effectiveness of flurbiprofen.
Topics: Adult; Aged; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Female; Flurbiprofen; Humans; | 2005 |
Comparison of conscious sedation for oocyte retrieval between low-anxiety and high-anxiety patients.
Topics: Adult; Anxiety; Cohort Studies; Conscious Sedation; Double-Blind Method; Electrocardiography; Female | 2005 |
When nothing helps: propofol as sedative and antiemetic in palliative cancer care.
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Comorbidity; Female; Humans; Hypnotics and Sedatives; M | 2005 |
Comparison on pain on injection of a small particle size-lipid emulsion of propofol and standard propofol with or without lidocaine.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Fat Emulsions, Intravenous | 2005 |
[The injection pain of propofol with different emulsion].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Cross-Over Studies; Double-Blind Method; Emulsion | 2006 |
Remifentanil versus propofol for radio frequency treatment of atrial flutter.
Topics: Aged; Analgesia, Patient-Controlled; Analysis of Variance; Anesthetics, Intravenous; Atrial Flutter; | 2006 |
Propofol formulated with long-/medium-chain triglycerides reduces the pain of injection by target controlled infusion.
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Chemistry, Pharmaceutical; Dose-Resp | 2006 |
Clonidine-ephedrine combination reduces pain on injection of propofol and blunts hemodynamic stress responses during the induction sequence.
Topics: Analgesics; Anesthetics, Intravenous; Clonidine; Ephedrine; Female; Hemodynamics; Humans; Male; Midd | 2006 |
Discomfort on injection: a comparison between two formulations of propofol.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Infusions, I | 2006 |
Preventing pain during injection of propofol: effects of a new emulsion with lidocaine addition.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Emulsions; Female; Humans; Injections; Lidocaine; Male; | 2007 |
Venous occlusion with lidocaine for preventing propofol induced pain. A prospective double-blind randomized study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Double-Blind Method; Drug Comb | 2006 |
Etomidate-Lipuro is associated with considerably less injection pain in children compared with propofol with added lidocaine.
Topics: Adolescent; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Anesthetics, Intravenous; Anest | 2006 |
Influence of age on flurbiprofen axetil requirements for preventing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, vehicle-controlled, parallel-group, dose-ranging study.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Doubl | 2006 |
Cisatracurium or rocuronium versus rocuronium-cisatracurium combination.
Topics: Adolescent; Adult; Androstanols; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local | 2006 |
Lidocaine pretreatment for the prevention of propofol-induced transient motor disturbances in children during anesthesia induction: a randomized controlled trial in children undergoing invasive hematologic procedures.
Topics: Analysis of Variance; Anesthesia; Anesthetics, Local; Child; Child, Preschool; Diagnostic Techniques | 2006 |
Small-dose ketamine reduces the pain of propofol injection.
Topics: Adult; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 2006 |
Influence of aging on lidocaine requirements for pain on injection of propofol.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Intravenou | 2006 |
Prevention of pain on injection of propofol: a comparison of remifentanil with alfentanil in children.
Topics: Alfentanil; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Pre | 2007 |
Age-related differences in metoclopramide requirement for pain on injection of propofol.
Topics: Adult; Aged; Aging; Double-Blind Method; Female; Humans; Injections; Male; Metoclopramide; Middle Ag | 2006 |
Effect of a 0.5% dilution of propofol on pain on injection during induction of anesthesia in children.
Topics: Child; Child, Preschool; Double-Blind Method; Emulsions; Female; Humans; Injections; Male; Pain; Pro | 2007 |
Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Diphenhydramine; Double-B | 2007 |
Does dexmedetomidine reduce the injection pain due to propofol and rocuronium?
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Androstanols; Anesthesia, Intravenous; Dexme | 2007 |
Does dexmedetomidine reduce the injection pain due to propofol and rocuronium?
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Androstanols; Anesthesia, Intravenous; Dexme | 2007 |
Does dexmedetomidine reduce the injection pain due to propofol and rocuronium?
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Androstanols; Anesthesia, Intravenous; Dexme | 2007 |
Does dexmedetomidine reduce the injection pain due to propofol and rocuronium?
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Androstanols; Anesthesia, Intravenous; Dexme | 2007 |
Reduction of pain on injection of propofol: combination of pretreatment of remifentanil and premixture of lidocaine with propofol.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Drug | 2007 |
Lidocaine is more efficient than the choice of propofol formulations to reduce incidence of pain on induction.
Topics: Adult; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Emu | 2007 |
Sustained intravascular exposure to propofol does not prolong pain at the site of injection.
Topics: Anesthetics, Intravenous; Cross-Over Studies; Double-Blind Method; Female; Humans; Infusions, Intrav | 2007 |
Low-dose propofol reduces the incidence of moderate to severe local pain induced by the main dose.
Topics: Adult; Anesthetics, Intravenous; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind | 2007 |
Identification of sensory blockade by somatosensory and pain-induced evoked potentials.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Electroencephalography; Evoked Potentials; Evoked Po | 2007 |
Multimodal analgesia to prevent propofol-induced pain: pretreatment with remifentanil and lidocaine versus remifentanil or lidocaine alone.
Topics: Adult; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Lido | 2007 |
A combination of lidocaine (lignocaine) and remifentanil reduces pain during propofol injection.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Bl | 2007 |
A ketamine-propofol admixture does not reduce the pain on injection compared with a lidocaine-propofol admixture.
Topics: Anesthesia; Anesthetics, Intravenous; Child; Child, Preschool; Double-Blind Method; Drug Combination | 2007 |
Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration.
Topics: Analgesics; Anesthesia, Intravenous; Anesthetics, Intravenous; Double-Blind Method; Emulsions; Flurb | 2007 |
Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Antiemetics; Dose-Response Relationship, | 2007 |
Pain on injection of propofol: propofol LCT vs propofol MCT/LCT with or without lidocaine pretreatment.
Topics: Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Chi-Square Distribution; Female; | 2006 |
Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Anesthetics, Local; Double | 2008 |
Evaluation of low-dose propofol preadministration to attenuate vascular pain during induction of anesthesia.
Topics: Adult; Aged; Anesthetics, Intravenous; Chemistry, Pharmaceutical; Female; Humans; Injections; Male; | 2007 |
Reduction of pain during induction with target-controlled propofol and remifentanil.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Double-Blind Method; Drug Del | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Painless injection of propofol: pretreatment with ketamine vs thiopental, meperidine, and lidocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; | 2007 |
Prevention of propofol-induced injection pain by sufentanil: a placebo-controlled comparison with remifentanil.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Double-Blind | 2008 |
Propofol-ketamine vs propofol-fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes.
Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages; Blood Pressure; Burns; Chi | 2008 |
Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: a prospective, randomized, double-blind, parallel-group, placebo-controlled study.
Topics: Adult; Aged; Analgesics; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; | 2008 |
A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection.
Topics: Adult; Anesthetics, Intravenous; Female; Humans; Incidence; Pain; Pain Measurement; Propofol; Risk F | 2007 |
The effect of carrier intravenous fluid speed on the injection pain of propofol.
Topics: Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Pain; Propofol; Time Factors | 1995 |
Sedation with intravenous infusions of propofol or thiopentone. Effects on pain perception.
Topics: Adolescent; Adult; Aged; Depression, Chemical; Female; Hot Temperature; Humans; Hypnotics and Sedati | 1995 |
Prilocaine reduces injection pain caused by propofol.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroi | 1995 |
Modulating effects of lignocaine on propofol.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Anesthesia, Intravenous; Female; Forearm; Hand; Hu | 1995 |
Propofol injection pain: comparing the addition of lignocaine or metoclopramide.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Blood Pressure; Extrapyramidal Tracts; F | 1994 |
Pain during injection of propofol. The effect of prior administration of thiopentone.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Ma | 1994 |
Pain on injection of propofol.
Topics: Adult; Anesthesia, Intravenous; Anesthesia, Local; Chi-Square Distribution; Double-Blind Method; Fem | 1994 |
Pretreatment with alfentanil reduces pain caused by propofol.
Topics: Adolescent; Adult; Aged; Alfentanil; Double-Blind Method; Humans; Injections, Intravenous; Middle Ag | 1994 |
A comparison of the effect of propofol or thiopentone on the incidence and severity of suxamethonium-induced myalgia.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Female; Genitalia, Female; Humans; Incidence; Laparoscop | 1994 |
Pain on injection of propofol: modification by nitroglycerin.
Topics: Ambulatory Surgical Procedures; Female; Genital Diseases, Female; Hand; Humans; Injections, Intraven | 1993 |
Evaluation of diprivan as an intravenous anaesthetic induction agent: experiences in Nairobi, Kenya.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Female; Hemodynamics; Humans; Kenya; Male; Middle Aged; | 1993 |
Propofol analgesia in central pain: preliminary clinical observations.
Topics: Adult; Aged; Analgesia; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Male; Middle | 1995 |
Thiopentone pretreatment for propofol injection pain in ambulatory patients.
Topics: Adolescent; Adult; Ambulatory Care; Analysis of Variance; Anesthesia, Intravenous; Anesthetics, Intr | 1995 |
Prevention of pain on injection of propofol: a comparison of lidocaine with alfentanil.
Topics: Adolescent; Adult; Aged; Alfentanil; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intra | 1996 |
Reducing pain during propofol injection: the role of the solvent.
Topics: Adsorption; Anesthesia, Intravenous; Anesthetics, Intravenous; Fat Emulsions, Intravenous; Glycerol; | 1996 |
Is there implicit memory after propofol sedation?
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Conduction; Anesthesia, | 1996 |
Modification of pain on injection of propofol. A comparison of pethidine and lignocaine.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female | 1996 |
The effect of temperature upon pain during injection of propofol.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Middle Aged; P | 1996 |
[Prolactinemia in children anesthetized with propofol].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Convulsants; Cryptorchid | 1996 |
Alfentanil-mediated analgesia during propofol injection: no evidence for a peripheral action.
Topics: Adolescent; Adult; Aged; Alfentanil; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Loca | 1996 |
Injection pain with propofol. Reduction with aspiration of blood.
Topics: Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Lidocaine; Male; Pain; Phl | 1996 |
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Fe | 1996 |
Preventing pain during injection of propofol: the optimal dose of lidocaine.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Catheterization, Peripheral; Double-Blind Metho | 1996 |
Reduction of propofol pain--fentanyl vs lidocaine.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Female; F | 1996 |
Conscious sedation for interventional neuroradiology: a comparison of midazolam and propofol infusion.
Topics: Adult; Anesthetics, Intravenous; Anxiety; Attitude of Health Personnel; Cerebrovascular Disorders; C | 1997 |
[Rapid induction of anesthesia with propofol--comparison with thiopental].
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Hemodynamics; Humans; Male; Middle | 1996 |
Effects of topical nitroglycerin and intravenous lidocaine on propofol-induced pain on injection.
Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Double-Blind Method; Female; Humans; Injec | 1997 |
Propofol patient-controlled sedation during hip or knee arthroplasty in elderly patients.
Topics: Adjuvants, Anesthesia; Aged; Anesthesia, Conduction; Anxiety; Arthroplasty; Cognition; Conscious Sed | 1997 |
Subhypnotic propofol does not treat postoperative vomiting in children after adenotonsillectomy.
Topics: Adenoidectomy; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Antiemetics; C | 1997 |
[Premixing lidocaine reduces the incidence and severity of pain on injection of propofol].
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; Humans; Inje | 1997 |
[Effect of lidocaine administration mode on decreasing injection pain caused by propofol].
Topics: Anesthetics, Intravenous; Anesthetics, Local; Humans; Injections, Intravenous; Lidocaine; Pain; Pain | 1997 |
Effect of lignocaine and pH on propofol-induced pain.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Chemistry, Pharmaceutical; Do | 1997 |
Reduction of propofol injection pain with a double lumen i.v. set.
Topics: Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Incidence; Injections, Intravenous; M | 1997 |
Pretreatment with topical 60% lidocaine tape reduces pain on injection of propofol.
Topics: Administration, Cutaneous; Adult; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Loca | 1997 |
Pharmacokinetics and pharmacodynamics of propofol in a new solvent.
Topics: Adult; Anesthetics, Intravenous; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Combinations; E | 1997 |
The analgesic effect of fentanyl, morphine, meperidine, and lidocaine in the peripheral veins: a comparative study.
Topics: Adult; Analgesics; Double-Blind Method; Female; Fentanyl; Humans; Injections, Intravenous; Lidocaine | 1998 |
Pain on injection of propofol. A comparison of cold propofol with propofol premixed with lignocaine.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Cold Temperature; Double-Blin | 1998 |
Midazolam-flumazenil versus propofol anaesthesia for scoliosis surgery with wake-up tests.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; An | 1998 |
Comparison of intravenous retention of fentanyl and lidocaine on local analgesia in propofol injection pain.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local | 1997 |
Two methods of administration of propofol for dental sedation.
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Anesthesia, Dental; Anesthetics, Intravenous; Cons | 1998 |
The effect of ketamine pretreatment on propofol injection pain in 100 women.
Topics: Adolescent; Adult; Aged; Anesthetics, Dissociative; Anesthetics, Intravenous; Double-Blind Method; F | 1998 |
[Pain-free injection of propofol].
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Female; Fentanyl; Humans; Hypothermia, Induced; | 1998 |
[Sixty percent lidocaine tape alleviates pain on injection of propofol after diminishing venipuncture pain].
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Bandages; Female; Humans; Injections, Intraveno | 1998 |
[Reduction of pain on injection of propofol: a comparison of fentanyl with lidocaine].
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Drug Combinations; Fe | 1998 |
Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Anti-Anxiety Agents; Cros | 1998 |
Pain on injection of propofol: the mitigating influence of metoclopramide using different techniques.
Topics: Adult; Analgesics; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Chi-Square Di | 1999 |
Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Benzamidines; Double-Blind Met | 1998 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Ondansetron pretreatment to alleviate pain on propofol injection: a randomized, controlled, double-blinded study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrav | 1999 |
Midazolam/ketamine sedative combination compared with fentanyl/propofol/isoflurane anaesthesia for oocyte retrieval.
Topics: Adult; Anesthesia, General; Anesthetics; Female; Fentanyl; Humans; Hypnotics and Sedatives; Isoflura | 1999 |
Iontophoretically applied lidocaine reduces pain on propofol injection.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; Humans; Iont | 1999 |
Strict temperature control has no effect on injection pain with propofol.
Topics: Anesthetics, Intravenous; Female; Humans; Injections; Pain; Propofol; Temperature | 1999 |
Propofol-thiopentone admixture-hypnotic dose, pain on injection and effect on blood pressure.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Intravenous; | 1999 |
The optimal effective concentration of lidocaine to reduce pain on injection of propofol.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Dilatation and Curettage; Double-Blind Me | 1999 |
[Effects of speed of injection on anesthesia induction with propofol and fentanyl].
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Blood Pressure; Drug | 1999 |
[Effects of the bolus injection rate on anesthesia induction with propofol].
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pressure; Heart Ra | 1999 |
[Premixing of 5% dextrose in Ringer's acetate solution with propofol reduces incidence and severity of pain on propofol injection].
Topics: Adult; Aged; Anesthesia, General; Double-Blind Method; Female; Glucose; Humans; Injections, Intraven | 1999 |
Determination of the effective therapeutic dose of intrathecal sufentanil for extracorporeal shock wave lithotripsy.
Topics: Adolescent; Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, I | 1999 |
[Administration of propofol. Addition of lidocaine eases the pain].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anesthetics, Local; Drug Combi | 1999 |
A comparison of the cuffed oropharyngeal airway (COPA) with the laryngeal mask airway (LMA) during manually controlled positive pressure ventilation.
Topics: Adolescent; Adult; Aged; Alfentanil; Anesthetics, Intravenous; Carbon Dioxide; Female; Humans; Intra | 1999 |
A potential mechanism of propofol-induced pain on injection based on studies using nafamostat mesilate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anesthetics, Local; Benzamidin | 1999 |
Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non- | 2000 |
Remifentanil, propofol or both for conscious sedation during eye surgery under regional anaesthesia.
Topics: Adult; Aged; Anesthesia, Conduction; Anesthetics, Intravenous; Conscious Sedation; Female; Hemodynam | 1999 |
Propofol and pain on induction: the effect of injectate temperature in children.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Chi-Square Distribution; Child; Child, Preschool; Cold | 2000 |
Potency of propofol, thiopentone and ketamine at various endpoints in New Zealand White rabbits.
Topics: Anesthetics, Intravenous; Animals; Central Nervous System; Ketamine; Pain; Posture; Propofol; Rabbit | 2000 |
Induction pain perception after premedication with propofol vs lidocaine: a pilot study.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Female; Humans; Infusions, Intravenous; Intubation, In | 2000 |
Continuous propofol administration for suxamethonium-induced postoperative myalgia.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; Creatine Kinase | 1999 |
Propofol-sodium thiopental admixture reduces pain on injection.
Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Female; Hemodynamics; Humans; Injections, Intr | 2000 |
[Effect of pre-mixed lidocaine with propofol on propofol injection pain in elderly patients].
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Double-Blind Method; Drug Combinations; Female; | 2000 |
Epidural anesthesia with lidocaine reduces propofol injection pain.
Topics: Adult; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Fema | 2001 |
Pain on injection of propofol with or without infusion of carrier fluid.
Topics: Adult; Anesthetics, Intravenous; Cross-Over Studies; Double-Blind Method; Drug Carriers; Female; Hum | 2001 |
Propofol in an emulsion of long- and medium-chain triglycerides: the effect on pain.
Topics: Double-Blind Method; Emulsions; Humans; Injections, Intravenous; Pain; Propofol; Prospective Studies | 2001 |
Role of tramadol in reducing pain on propofol injection.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Me | 2001 |
Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine.
Topics: Adult; Androstanols; Anesthetics, Intravenous; Anesthetics, Local; Antiemetics; Double-Blind Method; | 2001 |
Orally administered clonidine significantly reduces pain during injection of propofol.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Chi-Square Distribution; Clonidine; Female; | 2001 |
[Injection pain from propofol-MCT-LCT in children. A comparison with propofol-LCT].
Topics: Adolescent; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Double-Blind Method; Emulsions | 2001 |
[Efficacy of simultaneous bolus injection of lidocaine with propofol on pain caused by propofol injection].
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; Humans; Inje | 2001 |
[Less pain on injection by a new formulation of propofol? A comparison with propofol LCT].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Injections, | 2001 |
[Pre-treatment with ketamine reduces incidence and severity of pain on propofol injection].
Topics: Adult; Aged; Anesthesia, General; Double-Blind Method; Female; Humans; Injections, Intravenous; Keta | 2002 |
The prevention of propofol injection pain by tramadol or ondansetron.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Double-Blind Method; Female; Humans; Male; Onda | 2002 |
Reduction of pain on injection of propofol: a comparison of fentanyl with remifentanil.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Fentanyl; Humans; Infusions, Intravenous; Pain; Pain M | 2002 |
Propofol infusion rate does not affect local pain on injection.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Cross-Over Studies; Double-Bli | 2002 |
Efficacy of microfiltration in decreasing propofol-induced pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Chi-Square Distribution; Doubl | 2002 |
[Prevention of pain on injection with propofol in children: comparison of nitrous oxide with lidocaine].
Topics: Analgesics; Child; Humans; Hypnotics and Sedatives; Injections; Lidocaine; Nitrous Oxide; Pain; Pain | 2002 |
Iontophoretically applied lidocaine and the prevention of pain associated with the injection of intravenous propofol: a comparison with intravenous lidocaine.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Double-Blind Method; Female; | 2002 |
[Fentanyl prevents the pain at the site of propofol injection].
Topics: Child; Child, Preschool; Fentanyl; Humans; Injections, Intravenous; Pain; Propofol | 1992 |
Pain on injection of propofol: comparison of lignocaine with metoclopramide.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Ma | 1992 |
Propofol requirements for induction of anesthesia in children of different age groups.
Topics: Adolescent; Age Factors; Alfentanil; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Child; | 1992 |
Injection pain, cardiovascular changes and recovery following induction of anaesthesia with propofol in combination with alfentanil or lignocaine in children.
Topics: Alfentanil; Anesthesia Recovery Period; Anesthesia, Intravenous; Child; Child, Preschool; Double-Bli | 1992 |
The minimum effective dose of lignocaine to prevent injection pain due to propofol in children.
Topics: Anesthesia, Intravenous; Anesthesia, Local; Child; Child, Preschool; Humans; Infant; Injections, Int | 1992 |
Lidocaine for the prevention of pain due to injection of propofol.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intravenou | 1992 |
Tourniquet at 50 mm Hg followed by intravenous lidocaine diminishes hand pain associated with propofol injection.
Topics: Adult; Drug Evaluation; Female; Hand; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; | 1992 |
Induction dose-response of propofol in unpremedicated children.
Topics: Age Factors; Anesthesia, Intravenous; Apnea; Child; Child, Preschool; Dose-Response Relationship, Dr | 1992 |
[The effect of alfentanil on pain caused by the injection of propofol during anesthesia induction in children].
Topics: Alfentanil; Anesthesia, Intravenous; Child; Child, Preschool; Double-Blind Method; Humans; Pain; Pai | 1991 |
Effect of prior administration of cold saline on pain during propofol injection. A comparison with cold propofol and propofol with lignocaine.
Topics: Adult; Aged; Anesthesia, Intravenous; Cold Temperature; Female; Humans; Lidocaine; Male; Middle Aged | 1991 |
Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally induced acute pain.
Topics: Acute Disease; Adult; Female; Humans; Lasers; Male; Middle Aged; Pain; Propofol; Thiopental | 1991 |
Pain on injection of propofol: effects of concentration and diluent.
Topics: Fat Emulsions, Intravenous; Glucose; Humans; Infusions, Intravenous; Injections; Pain; Propofol; Ski | 1991 |
Prevention of pain during injection of propofol.
Topics: Drug Therapy, Combination; Humans; Injections, Intravenous; Lidocaine; Pain; Premedication; Propofol | 1990 |
Modification of pain on injection of propofol--a comparison between lignocaine and procaine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Anesthesia, Local; Humans; Lido | 1991 |
Injection pain, intubating conditions and cardiovascular changes following induction of anaesthesia with propofol alone or in combination with alfentanil.
Topics: Adult; Alfentanil; Anesthesia, Intravenous; Double-Blind Method; Drug Combinations; Hemodynamics; Hu | 1991 |
Comparative evaluation of propofol or methohexitone as the sole anaesthetic agent for microlaryngeal surgery.
Topics: Anesthesia, Intravenous; Hemodynamics; Humans; Injections, Intravenous; Larynx; Methohexital; Micros | 1991 |
Optimal dose of lignocaine for preventing pain on injection of propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Double-Blind Method; Female; Hu | 1991 |
The effect, on injection pain, of adding lignocaine to propofol.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Double-Blind Method; Female; Humans; Injections, Intrave | 1990 |
Pain on injection of propofol. Methods of alleviation.
Topics: Double-Blind Method; Humans; Injections, Intravenous; Lidocaine; Mental Recall; Pain; Propofol; Rand | 1990 |
Pain on injection of propofol. Methods of alleviation.
Topics: Double-Blind Method; Humans; Injections, Intravenous; Lidocaine; Mental Recall; Pain; Propofol; Rand | 1990 |
Pain on injection of propofol. Methods of alleviation.
Topics: Double-Blind Method; Humans; Injections, Intravenous; Lidocaine; Mental Recall; Pain; Propofol; Rand | 1990 |
Pain on injection of propofol. Methods of alleviation.
Topics: Double-Blind Method; Humans; Injections, Intravenous; Lidocaine; Mental Recall; Pain; Propofol; Rand | 1990 |
Pain on injection of propofol: the effect of injectate temperature.
Topics: Double-Blind Method; Humans; Injections, Intravenous; Pain; Propofol; Randomized Controlled Trials a | 1990 |
Propofol as an induction agent in children: pain on injection and pharmacokinetics.
Topics: Anesthetics; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Drug Combinatio | 1989 |
Effect of diluting propofol on the incidence of pain on injection and venous sequelae.
Topics: Adult; Anesthesia, Intravenous; Anesthetics; Female; Humans; Male; Pain; Phenols; Postoperative Comp | 1989 |
Propofol: clinical strategies for preventing the pain of injection.
Topics: Adolescent; Adult; Aged; Anesthetics; Humans; Injections, Intravenous; Lidocaine; Middle Aged; Pain; | 1988 |
The reduction of pain on injection of propofol: the effect of addition of lignocaine.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Anesthetics; Double-Blind Method; Female; Humans; Inject | 1988 |
Propofol vs thiopentone as anaesthetic agents for short operative procedures.
Topics: Anesthesia, Intravenous; Anesthetics; Arrhythmias, Cardiac; Dilatation and Curettage; Female; Hemody | 1987 |
Comparison of the induction characteristics of thiopentone and propofol in children.
Topics: Adolescent; Anesthesia, Intravenous; Anesthetics; Apnea; Blood Pressure; Child; Child, Preschool; De | 1987 |
242 other studies available for propofol and Pain
| Article | Year |
|---|---|
Lidocaine for Reduction of Pain Induced by Propofol in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Cross-Sectional Studies; Doub | 2021 |
Effect of patient-controlled epidural analgesia with remifentanil combined with propofol on analgesia and pain mediators after cesarean section.
Topics: Analgesia, Epidural; Cesarean Section; Female; Humans; Pain; Pregnancy; Propofol; Remifentanil | 2022 |
Limited use of local anesthesia for open inguinal hernia repair: a qualitative study.
Topics: Anesthesia, Local; Hernia, Inguinal; Herniorrhaphy; Humans; Pain; Propofol; Remifentanil | 2022 |
Propofol Causes Sustained Ca2+ Elevation in Endothelial Cells by Stimulating Ryanodine Receptor and Suppressing Plasmalemmal Ca2+ Pump.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Endothelial Cells; Humans; Pain; Propofol; Reactive Oxy | 2022 |
Tracheostomy decreases continuous analgesia and sedation requirements.
Topics: Adult; Aged; Analgesia; Analgesics; Anti-Anxiety Agents; Endrin; Female; Fentanyl; Humans; Hypnotics | 2022 |
Dexmedetomidine and Propofol at End of Life in Pediatric Oncology: Trends in Palliative Sedation Therapy.
Topics: Child; Death; Dexmedetomidine; Humans; Neoplasms; Pain; Palliative Care; Propofol; Prospective Studi | 2023 |
Investigation of Behavioural Pain Scale, Critical Care Pain Observation Tool, nociceptive flexion reflex and pupillary dilatation reflex as predictors of behavioural reactions to nociceptive procedures in critically ill patients unable to self-report pain
Topics: Adult; Analgesics, Opioid; Critical Care; Critical Illness; Dilatation; Humans; Nociception; Pain; P | 2022 |
A subclinical dose of esketamine pretreatment for propofol and rocuronium injection pain.
Topics: Humans; Ketamine; Pain; Propofol; Rocuronium | 2022 |
Effects of remifentanil on brain responses to noxious stimuli during deep propofol sedation.
Topics: Anesthetics, Intravenous; Brain; Electroencephalography; Humans; Pain; Piperidines; Propofol; Remife | 2023 |
Effect of Propofol Intravenous Anesthesia Combined with Press-Needle Therapy on Analgesic Effect during Painless Abortion.
Topics: Analgesics; Anesthesia; Anesthesia, Intravenous; Female; Humans; Pain; Propofol | 2022 |
Age-Stratified Propofol Dosage for Pediatric Procedural Sedation and Analgesia.
Topics: Analgesia; Anesthesia; Child; Conscious Sedation; Humans; Hypnotics and Sedatives; Infant; Pain; Pro | 2023 |
Safety and Efficacy of Propofol- and Ketamine-Based Procedural Sedation Regimen in Pediatric Patients During Burn Repetitive Dressing Change: 10 Years Single Center Experience.
Topics: Bandages; Burns; Child; Child, Preschool; Humans; Hypnotics and Sedatives; Ketamine; Pain; Propofol; | 2023 |
Peri-operative multimodal monitoring: a real need or a luxury?
Topics: Anesthesia; Anesthetics, Intravenous; Humans; Pain; Pain Management; Propofol | 2023 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sed | 2022 |
Efficacy of lidocaine on preventing incidence and severity of pain associated with propofol using in pediatric patients: A PRISMA-compliant meta-analysis of randomized controlled trials: Erratum.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Double-Blind Method; Humans; Incidence; Injecti | 2022 |
Impact of fentanyl analgesia on the accuracy of HVPG measurements in patients with cirrhosis: a prospective, multicenter study.
Topics: Analgesia; Fentanyl; Humans; Liver Cirrhosis; Pain; Propofol; Prospective Studies | 2023 |
Effect of common OPRM1, COMT, SLC6A4, ABCB1, and CYP2B6 polymorphisms on perioperative analgesic and propofol demands on patients subjected to thyroidectomy surgery.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Cytochrome P-450 CYP2B6; Humans; Pain; Pai | 2023 |
Recovery Benefit With Total Intravenous Anesthesia in Patients Receiving Rhinoplasty.
Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Hum | 2023 |
Prospective observational study on the use of continuous intravenous ketamine and propofol infusion for prolonged sedation in critical care.
Topics: Child; Cohort Studies; Critical Care; Humans; Hypnotics and Sedatives; Ketamine; Pain; Propofol; Pro | 2023 |
Evaluation of Atypical Antipsychotics for the Facilitation of Weaning Sedation in Mechanically Ventilated Critically Ill Patients.
Topics: Analgesics, Opioid; Antipsychotic Agents; Critical Illness; Female; Humans; Hypnotics and Sedatives; | 2024 |
The risks of sedation and pain control during burn resuscitation: Increased opioids lead to over-resuscitation and hypotension.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Burns; Dexmedetomidine; Fluid Therapy; Humans; Hypnotics | 2023 |
Patient and staff perceptions of short procedural sedation with propofol for joint and fracture reductions in the Emergency Department: A qualitative study.
Topics: Adult; Conscious Sedation; Emergency Service, Hospital; Fracture Fixation; Humans; Hypnotics and Sed | 2023 |
Propofol for palliative sedation.
Topics: Delirium; Female; Humans; Hypnotics and Sedatives; Middle Aged; Pain; Palliative Care; Propofol; Psy | 2020 |
Pharmacologic Modulation of Noxious Stimulus-evoked Brain Activation in Cynomolgus Macaques Observed with Functional Neuroimaging.
Topics: Analgesia; Analgesics; Animals; Brain; Female; Functional Neuroimaging; Isoflurane; Macaca fascicula | 2020 |
Percutaneous Endoscopic Interlaminar Lumbar Discectomy with Local Anesthesia for L5-S1 Disc Herniation: A Feasibility Study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Local; Diskectomy, Percutaneous; En | 2019 |
The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund's Adjuvant.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Freund's Adjuvant; Inflammasomes; Inflammation; I | 2019 |
Spastic Cerebral Palsy Pain Improvement With Propofol: A Case Report.
Topics: Adult; Analgesics; Anesthetics, Intravenous; Cerebral Palsy; Humans; Hypnotics and Sedatives; Male; | 2020 |
Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium.
Topics: Adjuvants, Pharmaceutic; Adult; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Delirium; Dexme | 2021 |
Percutaneous hepatic biopsy under propofol sedation. A safe and effective procedure.
Topics: Biopsy; Conscious Sedation; Humans; Hypnotics and Sedatives; Pain; Propofol | 2020 |
Frontal electroencephalogram based drug, sex, and age independent sedation level prediction using non-linear machine learning algorithms.
Topics: Adult; Algorithms; Electroencephalography; Humans; Machine Learning; Pain; Propofol; Remifentanil | 2022 |
Frontal electroencephalogram based drug, sex, and age independent sedation level prediction using non-linear machine learning algorithms.
Topics: Adult; Algorithms; Electroencephalography; Humans; Machine Learning; Pain; Propofol; Remifentanil | 2022 |
Frontal electroencephalogram based drug, sex, and age independent sedation level prediction using non-linear machine learning algorithms.
Topics: Adult; Algorithms; Electroencephalography; Humans; Machine Learning; Pain; Propofol; Remifentanil | 2022 |
Frontal electroencephalogram based drug, sex, and age independent sedation level prediction using non-linear machine learning algorithms.
Topics: Adult; Algorithms; Electroencephalography; Humans; Machine Learning; Pain; Propofol; Remifentanil | 2022 |
Propofol extravasation pain masked by lignocaine premedication.
Topics: Anesthetics, Intravenous; Humans; Lidocaine; Pain; Premedication; Propofol | 2021 |
Should lidocaine routinely be used to prevent pain on propofol injection during induction of general anaesthesia or sedation?
Topics: Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Humans; Lidocaine; Pain; Propofol | 2021 |
Patient satisfaction with procedural sedation in the emergency department.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Conscious Sedation; Emergency Service, Hospital; Female | 2017 |
Editorial: Polyps, Pain, and Propofol: Is Water Exchange the Panacea for All?
Topics: China; Colonoscopy; Insufflation; Pain; Polyps; Propofol; Prospective Studies; Water | 2017 |
Lornoxicam use to reduce the pain associated with propofol injection.
Topics: Administration, Intravenous; Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Pa | 2017 |
Utility of nociceptive flexion reflex threshold and bispectral index to predict movement responses under propofol anaesthesia.
Topics: Anesthesia, General; Consciousness Monitors; Electric Stimulation; Female; Humans; Male; Middle Aged | 2017 |
BET 1: Lidocaine with propofol to reduce pain on injection.
Topics: Adult; Anesthetics, Local; Humans; Injections; Lidocaine; Male; Pain; Propofol | 2017 |
Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Critical Care; Delirium; Dexmedetomidine; Female; Humans; H | 2018 |
The evaluation of the effect of venous diameter measurement by ultrasonography on pain and withdrawal response.
Topics: Adult; Anesthesia, General; Female; Humans; Incidence; Injections, Intravenous; Male; Middle Aged; M | 2018 |
Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Anesthesia, General; Delirium; Dexmed | 2018 |
Propofol partially attenuates complete freund's adjuvant-induced neuroinflammation through inhibition of the ERK1/2/NF-κB pathway.
Topics: Animals; Disease Models, Animal; Freund's Adjuvant; Gene Expression Regulation; Humans; Inflammation | 2019 |
Procedural sedation and analgesia in the emergency department in Japan: interim analysis of multicenter prospective observational study.
Topics: Aged; Analgesia; Anesthesia; Conscious Sedation; Electric Countershock; Emergency Service, Hospital; | 2019 |
Palliative Sedation via Intraosseous Vascular Access: A Safe and Feasible Way to Obtain a Vascular Access End of Life.
Topics: Drug Administration Routes; Home Care Services; Humans; Hypnotics and Sedatives; Infusions, Intraoss | 2019 |
Experience of adverse events with cerebral propofol testing in patients with drug resistant epilepsy.
Topics: Adult; Affective Symptoms; Anesthetics, Intravenous; Apathy; Drug Resistant Epilepsy; Female; Humans | 2019 |
Inhaled methoxyflurane for the reduction of acute anterior shoulder dislocation in the emergency department.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Emergency Service | 2019 |
Propofol-based palliative sedation in terminally ill children with solid tumors: A case series.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Hypnotics and Sedatives; Male; Neoplasms; Pain; | 2019 |
Comparison of the Effects of Midazolam/Fentanyl, Midazolam/Propofol, and Midazolam/Fentanyl/Propofol on Cognitive Function After Gastrointestinal Endoscopy.
Topics: Analgesics, Opioid; Cognition; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Female; Fenta | 2019 |
Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation.
Topics: Adult; Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Attitude of Health Personnel; Benzo | 2019 |
MULTIMODAL LOW-OPIOID ANESTHESIA - A NEW APPROACH TO THE ISSUE OF ADEQUATE INTRAOPERATIVE ANALGESIA.
Topics: Aged; Analgesia; Analgesics, Opioid; Anesthesiology; Child; Child, Preschool; Fentanyl; Humans; Pain | 2019 |
Propofol Compared to Midazolam Sedation and to General Anesthesia for Percutaneous Microwave Ablation in Patients with Hepatic Malignancies: A Single-Center Comparative Analysis of Three Historical Cohorts.
Topics: Ablation Techniques; Aged; Anesthesia, General; Cohort Studies; Female; Humans; Hypnotics and Sedati | 2019 |
[Palliative sedation in a man with oral cancer; the Royal Dutch Medical Association guidelines not always sufficient].
Topics: Carcinoma, Squamous Cell; Conscious Sedation; Humans; Hypnotics and Sedatives; Male; Midazolam; Midd | 2013 |
Colonoscopy: Sliding into the depths of sedation--is this what we want?
Topics: Anesthetics, Intravenous; Colonoscopy; Conscious Sedation; Culture; Deep Sedation; Humans; Intestina | 2013 |
Robust closed-loop control of induction and maintenance of propofol anesthesia in children.
Topics: Adolescent; Algorithms; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; | 2013 |
Sedation for interventional gastrointestinal endoscopic procedures: are we overlooking the “pain”?
Topics: Analgesia; Analgesics; Anesthetics, Combined; Endoscopy, Gastrointestinal; Female; Fentanyl; Gallsto | 2014 |
Prediction of nociceptive responses during sedation by time-frequency representation.
Topics: Consciousness Monitors; Electroencephalography; Endoscopy; Entropy; Humans; Hypnotics and Sedatives; | 2013 |
Variations of the analgesia nociception index during propofol anesthesia for total knee replacement.
Topics: Aged; Aged, 80 and over; Anesthetics, Intravenous; Arthroplasty, Replacement, Knee; Blood Pressure; | 2014 |
Incidence of and indications for conversion of cervical plexus block to general anesthesia in patients undergoing carotid surgery: a single center experience.
Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Carotid Arteries; Cervical | 2015 |
Safety analysis of endoscopist-directed propofol sedation: a prospective, national multicenter study of 24 441 patients in German outpatient practices.
Topics: Colonoscopy; Conscious Sedation; Dizziness; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 2014 |
Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia.
Topics: Ambulatory Surgical Procedures; Analgesics; Anesthesia, General; Anesthetics, General; Consciousness | 2014 |
Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia.
Topics: Ambulatory Surgical Procedures; Analgesics; Anesthesia, General; Anesthetics, General; Consciousness | 2014 |
Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia.
Topics: Ambulatory Surgical Procedures; Analgesics; Anesthesia, General; Anesthetics, General; Consciousness | 2014 |
Monitoring hypnotic effect and nociception with two EEG-derived indices, qCON and qNOX, during general anaesthesia.
Topics: Ambulatory Surgical Procedures; Analgesics; Anesthesia, General; Anesthetics, General; Consciousness | 2014 |
Emergency department procedural sedation: the London experience.
Topics: Academic Medical Centers; Adult; Aged; Analgesia; Cohort Studies; Confidence Intervals; Conscious Se | 2015 |
Propofol-induced pain sensation involves multiple mechanisms in sensory neurons.
Topics: Action Potentials; Anesthetics, Intravenous; Animals; Calcium Channels; Ganglia, Spinal; HEK293 Cell | 2015 |
Pain and satisfaction during rigid cystoscopic ureteral stent removal: a preliminary study.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Cross-Sectional Studies; Cystoscopy; Device Removal; H | 2014 |
Comparison of two treatments with skewed ordinal responses.
Topics: Analgesics; Biostatistics; Computer Simulation; Humans; Ketamine; Logistic Models; Models, Statistic | 2016 |
Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex.
Topics: Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Extracellular Signal-Regulated MAP Kina | 2015 |
Clustering of capnogram features to track state transitions during procedural sedation.
Topics: Anesthetics, Intravenous; Anxiety; Capnography; Case-Control Studies; Cluster Analysis; Conscious Se | 2015 |
Changes in the Bispectral Index in Response to Loss of Consciousness and No Somatic Movement to Nociceptive Stimuli in Elderly Patients.
Topics: Adult; Aged; Electroencephalography; Female; Humans; Male; Middle Aged; Movement Disorders; Pain; Pi | 2016 |
Effect of Lipid Composition in Propofol Formulations: Decisive Component in Reducing the Free Propofol Content and Improving Pharmacodynamic Profiles.
Topics: Anesthetics; Animals; Chemistry, Pharmaceutical; Emulsions; Lipids; Male; Nanoparticles; Pain; Propo | 2017 |
Sedation by Propofol for Painful Care Procedures at the End of Life: A Pilot Study. PROPOPAL 1.
Topics: Adult; Aged; Aged, 80 and over; Female; France; Humans; Hypnotics and Sedatives; Male; Middle Aged; | 2017 |
Chitosan Oligosaccharide Reduces Propofol Requirements and Propofol-Related Side Effects.
Topics: Adult; Animals; Chitosan; Female; Humans; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; O | 2016 |
Propofol versus midazolam for procedural sedation in the emergency department: A study on efficacy and safety.
Topics: Aged; Aged, 80 and over; Conscious Sedation; Emergency Treatment; Female; Humans; Hypnotics and Seda | 2017 |
Is propofol injection pain really important to patients?
Topics: Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Male; Mental Recall; Middl | 2017 |
Total intravenous anesthesia produces outcomes superior to those with combined intravenous-inhalation anesthesia for laparoscopic gynecological surgery at high altitude.
Topics: Adolescent; Adult; Altitude; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Inhal | 2017 |
Synergistic antinociceptive effects of alfentanil and propofol in the formalin test.
Topics: Alfentanil; Analgesics; Animals; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Male; P | 2017 |
Assessment of sedation-analgesia by means of Poincaré analysis of the electroencephalogram.
Topics: Anesthesia, General; Electroencephalography; Hypnotics and Sedatives; Nonlinear Dynamics; Pain; Pipe | 2016 |
Sedation challenge.
Topics: Alfentanil; Anesthesia, Dental; Anti-Anxiety Agents; Conscious Sedation; Dental Anxiety; Humans; Hyp | 2008 |
Physicochemical properties, pharmacokinetics, and pharmacodynamics of a reformulated microemulsion propofol in rats.
Topics: Adult; Anesthetics, Intravenous; Animals; Bradykinin; Chromatography, High Pressure Liquid; Dose-Res | 2008 |
On computers, nurses, and propofol: further evidence for the jury?
Topics: Ambulatory Care; Anesthesia, Intravenous; Anesthetics, Intravenous; Computers; Conscious Sedation; C | 2008 |
Recent advances in patient-controlled sedation.
Topics: Analgesia, Patient-Controlled; Conscious Sedation; Equipment Design; Humans; Hypnotics and Sedatives | 2008 |
Injection pain due to propofol in children and the ethics of placebo.
Topics: Anesthetics, Intravenous; Child; Child, Preschool; Ethics, Research; Humans; Injections, Intravenous | 2008 |
Injection pain due to propofol in children and the ethics of placebo.
Topics: Anesthetics, Local; Child; Child, Preschool; Ethics Committees, Research; Ethics, Research; Humans; | 2008 |
Heart rate variability during total intravenous anesthesia: effects of nociception and analgesia.
Topics: Adult; Afferent Pathways; Anesthetics; Anesthetics, Intravenous; Arrhythmias, Cardiac; Consciousness | 2009 |
Actions of propofol on substantia gelatinosa neurones in rat spinal cord revealed by in vitro and in vivo patch-clamp recordings.
Topics: Anesthetics, Intravenous; Animals; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Inhi | 2009 |
The k-in-a-row up-and-down design, revisited.
Topics: Anesthesiology; Anesthetics, Intravenous; Biometry; Clinical Trials, Phase I as Topic; Humans; Marko | 2009 |
Inadvertent intraarterial injection of propofol in a patient under general anesthesia.
Topics: Anesthesia, General; Anesthetics, Intravenous; Arthroplasty, Replacement, Hip; Female; Hand Joints; | 2009 |
Propofol/alfentanil and propofol/ketamine procedural sedation in children with acute lymphoblastic leukaemia: safety, efficacy and their correlation with pain neuromediator expression.
Topics: Adolescent; Alfentanil; Anxiety; Child; Child, Preschool; Conscious Sedation; Cross-Over Studies; Dr | 2010 |
Use of epidurally derived evoked potentials for quantification of caudal nociception in ponies.
Topics: Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Evoked Potentials, Somatosensor | 2009 |
Preventing pain on injection of propofol: a comparison between peripheral ketamine pre-treatment and ketamine added to propofol.
Topics: Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Ketamine; Male; Middle Age | 2009 |
Ouch! My hand burns.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Drug Combinations; Ephedrine; Humans; Hydrogen-Io | 2010 |
[Effect of noxious stimulation on regional distribution of propofol in canine spinal cord].
Topics: Animals; Dogs; Female; Male; Nociceptors; Pain; Physical Stimulation; Propofol; Random Allocation; S | 2010 |
Effects of anesthetic propofol on release of amino acids from the spinal cord during visceral pain.
Topics: Amino Acids; Anesthetics, Intravenous; Animals; Disease Models, Animal; Male; Muscle Contraction; No | 2010 |
Propofol modulates agonist-induced transient receptor potential vanilloid subtype-1 receptor desensitization via a protein kinase Cepsilon-dependent pathway in mouse dorsal root ganglion sensory neurons.
Topics: Anesthetics, Intravenous; Animals; Blotting, Western; Calcium; Cell Separation; Ganglia, Spinal; Imm | 2010 |
Treatment of pain on injection with propofol: not a trivial matter!
Topics: Anesthetics, Intravenous; Humans; Injections, Intravenous; Pain; Propofol | 2010 |
Evaluation of dexmedetomidine versus propofol-based sedation therapy in mechanically ventilated cardiac surgery patients at a tertiary academic medical center.
Topics: Aged; Aged, 80 and over; Cardiac Surgical Procedures; Clinical Protocols; Dexmedetomidine; Female; H | 2010 |
Pain after injection of a new formulation of propofol in six dogs.
Topics: Anesthetics, Intravenous; Animals; Dog Diseases; Dogs; Female; Male; Pain; Pain Measurement; Propofo | 2010 |
Prevention of pain from propofol injection.
Topics: Anesthetics, Intravenous; Humans; Hypnotics and Sedatives; Injections, Intravenous; Pain; Propofol | 2011 |
PropoClear 10 mg/ml emulsion for injection for cats and dogs.
Topics: Anesthetics, Intravenous; Animals; Cats; Dogs; Drug Recalls; Pain; Propofol | 2011 |
Is propofol an analgesic?
Topics: Analgesics; Anesthetics, Intravenous; Humans; Pain; Pain Measurement; Pain Threshold; Pain, Postoper | 2011 |
Prospective, observational study of the depth of anesthesia during oocyte retrieval using a total intravenous anesthetic technique and the Bispectral index monitor.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Conscious Sedation; Female; Fentanyl; Huma | 2011 |
[Procedural sedation with propofol in non-painful interventions in children].
Topics: Adolescent; Anxiety; Child; Child, Preschool; Consciousness; Diagnostic Tests, Routine; Female; Huma | 2011 |
Electrochemical quantification of 2,6-diisopropylphenol (propofol).
Topics: Anesthetics; Carbon; Electrochemistry; Electrodes; Glass; Humans; Hydrogen-Ion Concentration; Limit | 2011 |
Audit of recall of propofol injection pain.
Topics: Adult; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Male; Mental Recall; Middl | 2011 |
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section | 2012 |
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section | 2012 |
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section | 2012 |
Preoperative anxiety and pain sensitivity are independent predictors of propofol and sevoflurane requirements in general anaesthesia.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anxiety; Consciousness Monitors; Cross-Section | 2012 |
Assessment of pain in sedated and mechanically ventilated patients: an observational study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Analysis of Variance; Behavior; Cons | 2012 |
Incidence of propofol injection pain and effect of lidocaine pretreatment during upper gastrointestinal endoscopy.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Female; Humans; Injections, Intravenous; Male; Pain | 2012 |
Comparative canine pharmacokinetics-pharmacodynamics of fospropofol disodium injection, propofol emulsion, and cyclodextrin-enabled propofol solution following bolus parenteral administration.
Topics: Anesthetics, Intravenous; Animals; beta-Cyclodextrins; Brain Waves; Chemistry, Pharmaceutical; Consc | 2012 |
Receptor specificity defines algogenic properties of propofol and fospropofol.
Topics: Animals; Cells, Cultured; Hypnotics and Sedatives; Injections, Intravenous; Male; Pain; Prodrugs; Pr | 2012 |
How can 5-HT(3) receptor antagonists exert analgesic properties?
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Female; Hand; Humans; Male; Ondansetron; Pain; Propofo | 2012 |
[Variation in the bispectral index during the Jannetta technique].
Topics: Arteries; Artifacts; Cerebellum; Consciousness Monitors; Craniotomy; Decompression, Surgical; Diagno | 2012 |
Effects of propofol and dexmedetomidine on motor coordination and analgesia: a comparative analysis.
Topics: Analgesics; Animals; Behavior, Animal; Dexmedetomidine; Disease Models, Animal; Hot Temperature; Mal | 2012 |
Can propofol mimic alcohol-related pain in patients with Hodgkin lymphoma?
Topics: Adult; Ethanol; Female; Hodgkin Disease; Humans; Pain; Propofol | 2012 |
Effects of propofol, sevoflurane, remifentanil, and (S)-ketamine in subanesthetic concentrations on visceral and somatosensory pain-evoked potentials.
Topics: Adult; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intraven | 2013 |
Pairwise comparisons with ordered categorical data.
Topics: Alfentanil; Child; Child, Preschool; Clinical Trials as Topic; Computer Simulation; Humans; Logistic | 2013 |
Safe lumbar puncture under analgo-sedation in children with acute lymphoblastic leukemia.
Topics: Adolescent; Central Nervous System; Child; Child, Preschool; Deep Sedation; Female; Humans; Infant; | 2014 |
Are children just little adults when it comes to propofol injection pain?
Topics: Anesthetics, Intravenous; Child; Humans; Injections, Intravenous; Pain; Propofol | 2002 |
Profound pain due to propofol injection triggered myocardial ischemia in a patient with a suspected pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Anesthetics, Intravenous; Electrocardiography; Humans; Male; Myocard | 2003 |
Comparison of colonoscopies performed under sedation with propofol or with midazolam or without sedation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Colonoscopy; Female; Heart Rate; Humans; | 2003 |
Alternative application site of transdermal nitroglycerin and the reduction of pain on propofol injection.
Topics: Administration, Cutaneous; Anesthetics, Intravenous; Female; Humans; Male; Middle Aged; Nitroglyceri | 2003 |
Transcranial magnetic cortical stimulation relieves central pain.
Topics: Adult; Aged; Electromagnetic Phenomena; Female; Humans; Male; Middle Aged; Motor Cortex; Pain; Pain | 2002 |
Spinal carbonic anhydrase contributes to nociceptive reflex enhancement by midazolam, pentobarbital, and propofol.
Topics: Acetazolamide; Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ethoxzolamide; Hypnotics | 2003 |
A survey of combined epidural-propofol anesthesia with noninvasive positive pressure ventilation as a minimally invasive anesthetic protocol.
Topics: Adult; Aged; Analgesia, Epidural; Anesthesia, Epidural; Anesthetics, Intravenous; Carbon Dioxide; Da | 2003 |
[Use of propofol for painful procedures in cancer pain management].
Topics: Aged; Anesthesia, Local; Anesthetics, Intravenous; Female; Fractures, Spontaneous; Humans; Male; Mid | 2003 |
[Remifentanil and sedation in colonoscopy].
Topics: Aged; Analgesics; Colonoscopy; Drug Evaluation; Humans; Hypnotics and Sedatives; Middle Aged; Nausea | 2002 |
Remifentanil to reduce pain on injection of propofol.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Humans; Pain; Piperidines; Propofol; Remifentanil | 2004 |
Evaluation of the use of anesthesia and analgesia in reptiles.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Butorphanol; Humans; Hypothermi | 2004 |
Ketamine to reduce propofol injection pain.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Clinical Trials as Topic; Drug Combinations; Dr | 2004 |
The continuing conundrum of sedation for painful and nonpainful procedures.
Topics: Anesthesia, General; Anesthetics, Intravenous; Anxiety; Carbon Dioxide; Child; Clinical Protocols; C | 2004 |
Don't use thiopental to decrease propofol injection pain.
Topics: Anesthetics, Intravenous; Humans; Injections, Intravenous; Pain; Propofol; Thiopental | 2004 |
Developing yet another spinal analgesic drug?
Topics: Analgesia; Analgesics; Animals; Disease Models, Animal; Injections, Spinal; Pain; Propofol; Rats | 2004 |
Intrathecal propofol has analgesic effects on inflammation-induced pain in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Hot Temperature; Inflammation; Injections | 2004 |
Comparative evaluation of the Datex-Ohmeda S/5 Entropy Module and the Bispectral Index monitor during propofol-remifentanil anesthesia.
Topics: Acoustic Stimulation; Adult; Algorithms; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, | 2004 |
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnot | 2004 |
Pretreatment with flurbiprofen axetil and venous occlusion to reduce pain during injection of propofol.
Topics: Adult; Analgesics; Analysis of Variance; Anesthetics, Intravenous; Female; Flurbiprofen; Hand; Human | 2004 |
Pain reduction by IV butorphanol prior to propofol.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Butorphanol; Humans; Injections, Intravenous; Pain; Pr | 2005 |
Pain on injection of Cleofol.
Topics: Anesthetics, Intravenous; Chemistry, Pharmaceutical; Diet, Vegetarian; Humans; Injections, Intraveno | 2005 |
Evidence for peripherally antinociceptive action of propofol in rats: behavioral and spinal neuronal responses to subcutaneous bee venom.
Topics: Analgesics; Animals; Bee Venoms; Behavior, Animal; Consciousness; Male; Nociceptors; Pain; Posterior | 2005 |
The prevention of pain from injection of propofol by dexmedetomidine and comparison with lidocaine.
Topics: Dexmedetomidine; Humans; Injections, Intravenous; Lidocaine; Pain; Propofol | 2005 |
Mechanism of action of metoprolol in reducing propofol-induced pain.
Topics: Anesthetics, Intravenous; Animals; Humans; Metoprolol; Pain; Propofol; Sympatholytics | 2005 |
Propofol-induced injection pain: comparison of a modified propofol emulsion and standard propofol with premixed lidocaine.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Drug Combinations; Emulsions; | 2005 |
Comparison of propofol with lidocaine pretreatment versus propofol formulated with long- and medium-chain triglycerides or confounding effect of tourniquet.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Chemistry, Pharmaceutical; Excipients; Humans; Injecti | 2005 |
Characteristics of propofol-evoked vascular pain in anaesthetized rats.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Animals; Capsaicin; Cyclooxygenase | 2005 |
Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Electr | 2005 |
Diclofenac pretreatment for propofol.
Topics: Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Fentanyl; Humans; Mid | 2005 |
Can propofol precipitate pancreatitis in patients with Cushing's syndrome?
Topics: Acute Disease; Adult; Amylases; Anesthetics, Intravenous; Cushing Syndrome; Female; Humans; Hypophys | 2005 |
Tracheal intubation in routine practice with and without muscular relaxation: an observational study.
Topics: Adult; Anesthetics, Intravenous; Atracurium; Female; Follow-Up Studies; Humans; Hydroxyzine; Hypnoti | 2005 |
[Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory].
Topics: Anesthesia, General; Anesthetics, Intravenous; Female; Humans; Injections, Intravenous; Male; Memory | 2005 |
The suppression of spinal F-waves by propofol does not predict immobility to painful stimuli in humans.
Topics: Adult; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Electric Stimulation; Electroence | 2006 |
Attitudes of children with leukemia toward repeated deep sedations with propofol.
Topics: Adolescent; Age Factors; Anxiety; Attitude; Bone Marrow Examination; Child; Child, Preschool; Fear; | 2005 |
[Sedation in children: how and for who?].
Topics: Alfentanil; Anesthesia, General; Child; Conscious Sedation; Contraindications; Cooperative Behavior; | 2006 |
Procedural sedation and analgesia in children.
Topics: Analgesia; Analgesics; Child; Conscious Sedation; Drug Combinations; Humans; Hypnotics and Sedatives | 2006 |
Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit.
Topics: Animals; Formaldehyde; Immunohistochemistry; Mice; Pain; Propofol; Protein Subunits; Proto-Oncogene | 2006 |
Propofol by infusion protocol for ED procedural sedation.
Topics: Adolescent; Adult; Aged; Clinical Protocols; Conscious Sedation; Delusions; Dose-Response Relationsh | 2006 |
Anesthesia and electroconvulsive therapy: a retrospective study comparing etomidate and propofol.
Topics: Anesthetics; Electroconvulsive Therapy; Etomidate; Female; Humans; Male; Middle Aged; Pain; Propofol | 2006 |
Severe myalgia associated with propofol sedation.
Topics: Adolescent; Conscious Sedation; Humans; Muscles; Pain; Propofol | 2007 |
Relation between bitter taste sensitivity and incidence or intensity of propofol injection pain.
Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Dysgeusia; Elective Surgical Procedures; Femal | 2007 |
Profound pain due to propofol injection triggered severe bronchospasm in a smoker--A case report.
Topics: Albuterol; Aminophylline; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Inflammatory Agent | 2006 |
Propofol fear: 'mommy, I don't want the white stuff'.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Fear; Humans; Pain; Propofol | 2006 |
Modulation of neuronal activity in CNS pain pathways following propofol administration in rats: Fos and EEG analysis.
Topics: Anesthesia; Anesthetics, Intravenous; Anesthetics, Local; Animals; Central Nervous System; Conscious | 2007 |
The use of propofol sedation for transrectal ultrasonography-guided prostate biopsy is associated with high patient satisfaction and acceptability.
Topics: Anesthetics, Intravenous; Anxiety; Biopsy; Conscious Sedation; Humans; Male; Pain; Patient Satisfact | 2007 |
Deep sedation with intravenous infusion of combined propofol and ketamine during dressing changes and whirlpool bath in patients with severe epidermolysis bullosa.
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Anti-Bacterial Agents; Antibiotics, Antitubercular | 2007 |
Current state of sedation/analgesia care in dentistry.
Topics: Anesthesia, Dental; Conscious Sedation; Dental Anxiety; Dentistry; Dexmedetomidine; Humans; Hypnotic | 2007 |
Current world literature.
Topics: Anesthesiology; Dexmedetomidine; Emergency Service, Hospital; Endoscopy, Gastrointestinal; Humans; H | 2007 |
Ketamine versus lidocaine for the pain of propofol injection.
Topics: Humans; Injections, Intravenous; Ketamine; Lidocaine; Pain; Propofol | 2007 |
Ketamine for reducing propofol-induced pain.
Topics: Humans; Ketamine; Pain; Propofol | 2007 |
Neurons in the ventral spinal cord are more depressed by isoflurane, halothane, and propofol than are neurons in the dorsal spinal cord.
Topics: Action Potentials; Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Animal | 2007 |
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio | 2007 |
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio | 2007 |
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio | 2007 |
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio | 2007 |
Strychnine-sensitive glycine receptors mediate the analgesic but not the hypnotic effects of emulsified volatile anaesthetics.
Topics: Anesthetics, Intravenous; Drug Delivery Systems; Humans; Pain; Propofol; Receptors, Glycine; Strychn | 2008 |
Vertebral augmentation: toward a safe and pain-free method for back pain.
Topics: Anesthetics, Intravenous; Fentanyl; Fractures, Spontaneous; Humans; Pain; Propofol; Spinal Fractures | 2008 |
Assisted sedation: a safe and easy method for pain-free percutaneous vertebroplasty.
Topics: Aged; Anesthetics, Intravenous; Conscious Sedation; Female; Fentanyl; Humans; Hypnotics and Sedative | 2008 |
Pain on injection of propofol - why bother?
Topics: Anesthetics, Intravenous; Humans; Injections, Intravenous; Pain; Propofol | 2008 |
Design and evaluation of microemulsions for improved parenteral delivery of propofol.
Topics: Animals; Diffusion; Drug Carriers; Drug Compounding; Drug Design; Drug Evaluation, Preclinical; Emul | 2008 |
Aspirin in the prevention of painful intravenous injection of disoprofol (ICI35,868) and diazepam (Valium).
Topics: Adolescent; Adult; Anesthesia, Intravenous; Anesthetics; Aspirin; Diazepam; Female; Fentanyl; Humans | 1982 |
Hyperalgesia during sedation: effects of barbiturates and propofol in the rat.
Topics: Animals; Barbiturates; Hyperalgesia; Male; Pain; Propofol; Rats; Rats, Sprague-Dawley; Sensory Thres | 1995 |
Pain during injection of propofol.
Topics: Humans; Injections, Intravenous; Lidocaine; Pain; Propofol; Thiopental | 1995 |
[Electric analgesia and endoscopic laser treatment: morphinans remain indispensable].
Topics: Aged; Aged, 80 and over; Alfentanil; Combined Modality Therapy; Electric Stimulation Therapy; Female | 1995 |
Pain during injection of propofol.
Topics: Humans; Injections, Intravenous; Pain; Propofol; Thiopental | 1995 |
[Pain associated with the injection of Diprivan].
Topics: Adolescent; Adult; Child; Drug Combinations; Humans; Injections, Intravenous; Lidocaine; Pain; Propo | 1994 |
Propofol injection pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Equipment Design; Female; Glass | 1994 |
Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model.
Topics: Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde | 1994 |
Drug-induced methemoglobinemia in a healthy 20-year-old soldier undergoing shoulder surgery.
Topics: Adult; Arthroscopy; Fentanyl; Humans; Male; Methemoglobinemia; Methylene Blue; Midazolam; Pain; Prop | 1993 |
Intra-arterial injection of propofol.
Topics: Accidents; Aged; Female; Humans; Injections, Intra-Arterial; Pain; Propofol | 1993 |
Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: intravenous infusion.
Topics: Anesthesia; Animals; Blood Pressure; Electroencephalography; Heart Rate; Hemodynamics; Infusions, In | 1993 |
Myalgia and biochemical changes following suxamethonium after induction of anaesthesia with thiopentone or propofol.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Creatine Kinase; Fasciculation; Female; Humans; Ma | 1993 |
Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects.
Topics: Action Potentials; Anesthetics, Intravenous; Animals; Blood Pressure; Cats; Ketamine; Neurons; Pain; | 1995 |
Lidocaine and no carrier fluid for the prevention of pain due to injection of propofol.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Humans; Injections, Intraveno | 1996 |
Reducing the pain on injection of propofol.
Topics: Alfentanil; Humans; Injections, Intravenous; Lidocaine; Pain; Pharmaceutical Vehicles; Propofol | 1996 |
The use of propofol for sedation in the emergency department.
Topics: Adult; Aged; Analgesia; Anesthetics, Intravenous; Conscious Sedation; Emergency Service, Hospital; F | 1996 |
Haemodynamic responses to incision and sternotomy in relation to the auditory evoked potential and spontaneous EEG.
Topics: Adult; Aged; Alfentanil; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Cardiac Surg | 1996 |
Psychophysical and electrophysiological responses to experimental pain may be influenced by sedation: comparison of the effects of a hypnotic (propofol) and an analgesic (alfentanil).
Topics: Adult; Alfentanil; Analgesics, Opioid; Evoked Potentials; Female; Humans; Hypnotics and Sedatives; M | 1996 |
Warmed propofol, a cautionary note.
Topics: Anesthetics, Intravenous; Drug Contamination; Hot Temperature; Humans; Infections; Pain; Postoperati | 1996 |
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Propofol | 1997 |
Pain on injection of propofol.
Topics: Anesthetics, Intravenous; Drug Stability; Humans; Injections, Intravenous; Pain; Propofol | 1997 |
Pain on injection of propofol.
Topics: Anesthetics, Intravenous; Humans; Injections, Intravenous; Pain; Propofol | 1997 |
Reduction by fentanyl of the Cp50 values of propofol and hemodynamic responses to various noxious stimuli.
Topics: Adult; Blood Pressure; Consciousness; Dose-Response Relationship, Drug; Evaluation Studies as Topic; | 1997 |
Attenuation of pain on injection of propofol--an unexpected benefit of co-induction with midazolam.
Topics: Anesthetics, Combined; Anesthetics, Intravenous; Humans; Midazolam; Pain; Propofol | 1998 |
Effects of target-controlled anesthesia with propofol and sufentanil on the hemodynamic response to Mayfield head holder application.
Topics: Adjuvants, Anesthesia; Alprazolam; Analysis of Variance; Anesthesia, Intravenous; Anesthetics, Intra | 1998 |
[Propofol anesthesia for craniotomy in patients who are awake].
Topics: Aged; Aged, 80 and over; Anesthesia, Intravenous; Craniotomy; Female; Humans; Hypnotics and Sedative | 1998 |
Thiopentone and propofol: a compatible mixture?
Topics: Anesthesia Recovery Period; Anesthetics, Intravenous; Chemical Phenomena; Chemistry, Physical; Cost- | 1998 |
Pain on injection of propofol.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Humans; Lidocaine; Pain; Propofol | 1998 |
Temperature of propofol does not reduce the incidence of injection pain.
Topics: Anesthetics, Intravenous; Clinical Trials as Topic; Double-Blind Method; Humans; Injections, Intrave | 1998 |
Injection pain with propofol: the effectiveness of thiopentone on induction.
Topics: Anesthetics, Intravenous; Child; Child, Preschool; Female; Humans; Injections, Intravenous; Male; Pa | 1998 |
Day-case laparoscopy revisited: have post-operative morbidity and patient acceptance improved?
Topics: Adult; Analgesics; England; Female; Humans; Incidence; Laparoscopy; Middle Aged; Morbidity; Nausea; | 1994 |
Raynaud's phenomenon and propofol.
Topics: Adult; Anesthetics, Intravenous; Humans; Male; Pain; Propofol; Raynaud Disease | 1999 |
[Suffering and abortion].
Topics: Abortion, Induced; Abortion, Legal; Adult; Alfentanil; Analgesia; Female; Humans; Pain; Pregnancy; P | 1999 |
Effects of propofol and remifentanil on phrenic nerve activity and nociceptive cardiovascular responses in rabbits.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Carbon Dioxide; Drug Interactions; Electrophysiol | 1999 |
Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats.
Topics: Analysis of Variance; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Central Ner | 2000 |
Propofol and analgesia.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Humans; Pain; Propofol | 2000 |
Drugs which cause pain on intravenous injection.
Topics: Androstanols; Anesthetics, Intravenous; Drug Combinations; Humans; Injections, Intravenous; Neuromus | 2000 |
Prospective evaluation of propofol anesthesia in the pediatric intensive care unit for elective oncology procedures in ambulatory and hospitalized children.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Biopsy, Needle; Bone Marrow Ex | 2000 |
A comparative study of induction and recovery characteristics of propofol and midazolam.
Topics: Adolescent; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Blood Pressure; Femal | 2001 |
Pain on injection with propofol.
Topics: Anesthetics, Intravenous; Chemistry, Pharmaceutical; Humans; Injections, Intravenous; Pain; Propofol | 2001 |
Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells.
Topics: Anesthetics, Intravenous; Binding Sites; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Dit | 2001 |
Use of propofol sedation in a pediatric emergency department: a prospective study.
Topics: Adolescent; Analgesics, Opioid; Anesthetics, Intravenous; Child; Child, Preschool; Emergency Service | 2001 |
Making patients safe and comfortable for a lifetime of dentistry: frontiers in office-based sedation.
Topics: Anesthesia, Dental; Anesthetics, Intravenous; Behavior Therapy; Child; Conscious Sedation; Cooperati | 2001 |
Propofol formulation and pain on injection.
Topics: Anesthetics, Intravenous; Emulsions; Humans; Injections, Intravenous; Pain; Propofol | 2002 |
A switch from propofol to etomidate during an ECT course increases EEG and motor seizure duration.
Topics: Aged; Aged, 80 and over; Anesthetics, Intravenous; Electroconvulsive Therapy; Electroencephalography | 2002 |
[Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain].
Topics: Animals; Female; Formaldehyde; Male; Neurons; Nitric Oxide Synthase; Pain; Propofol; Proto-Oncogene | 2002 |
Patient-maintained sedation for ERCP with a target-controlled infusion of propofol: a pilot study.
Topics: Analgesia, Patient-Controlled; Cholangiopancreatography, Endoscopic Retrograde; Humans; Hypnotics an | 2002 |
Respiratory response to skin incision during anaesthesia with infusions of propofol and alfentanil.
Topics: Adult; Aged; Alfentanil; Analgesics, Opioid; Anesthesia, General; Anesthetics, Intravenous; Dermatol | 2002 |
Propofol and barbiturate depression of spinal nociceptive neurotransmission.
Topics: Animals; Animals, Newborn; Depression, Chemical; Hyperalgesia; In Vitro Techniques; Pain; Pentobarbi | 1992 |
ECT anaesthetics.
Topics: Contraindications; Electroconvulsive Therapy; Humans; Lidocaine; Methohexital; Pain; Propofol | 1992 |
[Changes in the pain produced by the peripheral venous injection of propofol when it is combined with lidocaine or fentanyl].
Topics: Adolescent; Adult; Aged; Child; Female; Fentanyl; Humans; Injections, Intravenous; Lidocaine; Male; | 1992 |
A technique for reducing pain associated with propofol administration.
Topics: Humans; Pain; Propofol | 1992 |
[Propofol and pain caused by the injection].
Topics: Humans; Incidence; Injections, Intravenous; Pain; Propofol | 1991 |
[Comparison of the effect of propofol and that of pentobarbital on behavioral responses to somatic and visceral stimuli in rats].
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Male; Pain; Pentobarbital; Propofol; Ra | 1991 |
Propofol causes a burning sensation on injection.
Topics: Humans; Pain; Propofol; Thiopental | 1991 |
The induction dose of propofol in infants 1-6 months of age and in children 10-16 years of age.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Blood Pressure; Child; Dose-Response Relationship, Drug; | 1991 |
Cold statistics.
Topics: Cold Temperature; Humans; Pain; Propofol; Statistics as Topic | 1990 |
Reduction of pain on injection caused by propofol.
Topics: Adult; Alfentanil; Anesthesia, Intravenous; Double-Blind Method; Female; Fentanyl; Humans; Male; Pai | 1990 |
Abolition of injection pain due to propofol in children.
Topics: Anesthesia, Intravenous; Child; Child, Preschool; Humans; Infant; Lidocaine; Pain; Propofol | 1990 |
Intraarterial injection of propofol.
Topics: Adult; Humans; Injections, Intra-Arterial; Male; Medication Errors; Pain; Preanesthetic Medication; | 1990 |
Pain during injection and venous sequelae: thiopentone versus propofol.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Female; Humans; Middle Aged; Pain; Propofol; Thiop | 1990 |
The effects of speed of injection on induction with propofol. A comparison with etomidate.
Topics: Adult; Anesthesia, Intravenous; Anesthetics; Etomidate; Female; Genitalia, Female; Hemodynamics; Hum | 1989 |
Painful injection of propofol.
Topics: Anesthesia, Intravenous; Anesthetics; Humans; Pain; Phenols; Propofol | 1989 |
Prevention of pain on injection.
Topics: Anesthesia, Intravenous; Humans; Injections, Intravenous; Lidocaine; Pain; Phenols; Propofol | 1988 |
Multicentre study of propofol in day case surgery.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Int | 1988 |
Pain on injection of propofol.
Topics: Adult; Aged; Anesthetics; Humans; Infusions, Intravenous; Middle Aged; Pain; Phenols; Propofol | 1988 |
Pain on injection with propofol.
Topics: Anesthetics; Humans; Lidocaine; Pain; Phenols; Propofol | 1986 |
Comparison of induction characteristics of four intravenous anaesthetic agents.
Topics: Adult; Anesthesia, Intravenous; Anesthetics; Drug Evaluation; Etomidate; Female; Hemodynamics; Human | 1986 |
Effect of lignocaine on pain caused by propofol injection.
Topics: Adolescent; Adult; Anesthetics; Female; Humans; Lidocaine; Middle Aged; Pain; Phenols; Propofol | 1985 |
A review of the safety and tolerance of propofol ('Diprivan').
Topics: Akathisia, Drug-Induced; Anesthesia, Intravenous; Drug Tolerance; Hematologic Tests; Humans; Hydroco | 1985 |
Pain on i.v. injection of propofol (ICI 35 868) in emulsion formulation. Short communication.
Topics: Anesthetics; Emulsions; Humans; Injections, Intravenous; Pain; Phenols; Propofol | 1985 |
Assessment and modification of pain on induction with propofol (Diprivan).
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics; Apnea; Female; Hemodynamics; Humans; Lidocaine; M | 1985 |